dantrolene has been researched along with Glycogen Storage Disease Type V in 2 studies
Dantrolene: Skeletal muscle relaxant that acts by interfering with excitation-contraction coupling in the muscle fiber. It is used in spasticity and other neuromuscular abnormalities. Although the mechanism of action is probably not central, dantrolene is usually grouped with the central muscle relaxants.
dantrolene : The hydrazone resulting from the formal condensation of 5-(4-nitrophenyl)furfural with 1-aminohydantoin. A ryanodine receptor antagonist used for the relief of chronic severe spasticity and malignant hyperthermia.
Glycogen Storage Disease Type V: Glycogenosis due to muscle phosphorylase deficiency. Characterized by painful cramps following sustained exercise.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Five patients with McArdle's disease entered a double-blind, placebo-controlled, cross-over study of dantrolene sodium." | 2.67 | Dantrolene sodium does influence the second-wind phenomenon in McArdle's disease. Electrophysiological evidence during exercise in a double-blind placebo-controlled, cross-over study in 5 patients. ( Braakhekke, JP; Joosten, EM; Poels, PJ; Stegeman, DF, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (50.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lane, RJ | 1 |
| Turnbull, DM | 1 |
| Hudgson, P | 1 |
| Walton, J | 1 |
| Poels, PJ | 1 |
| Braakhekke, JP | 1 |
| Joosten, EM | 1 |
| Stegeman, DF | 1 |
2 trials available for dantrolene and Glycogen Storage Disease Type V
| Article | Year |
|---|---|
Trials of verapamil and dantrolene sodium in McArdle disease.
Topics: Calcium; Clinical Trials as Topic; Dantrolene; Glycogen Storage Disease; Glycogen Storage Disease Ty | 1984 |
Dantrolene sodium does influence the second-wind phenomenon in McArdle's disease. Electrophysiological evidence during exercise in a double-blind placebo-controlled, cross-over study in 5 patients.
Topics: Adult; Creatine Kinase; Dantrolene; Double-Blind Method; Electromyography; Exercise Test; Fatigue; F | 1990 |