dantrolene has been researched along with Genetic Predisposition in 20 studies
Dantrolene: Skeletal muscle relaxant that acts by interfering with excitation-contraction coupling in the muscle fiber. It is used in spasticity and other neuromuscular abnormalities. Although the mechanism of action is probably not central, dantrolene is usually grouped with the central muscle relaxants.
dantrolene : The hydrazone resulting from the formal condensation of 5-(4-nitrophenyl)furfural with 1-aminohydantoin. A ryanodine receptor antagonist used for the relief of chronic severe spasticity and malignant hyperthermia.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In this article the pathophysiology of malignant hyperthermia, its signs, symptoms and treatment as well as safe anesthetic agents for individuals susceptible to malignant hyperthermia are discussed." | 2.42 | [Malignant hyperthermia]. ( Glahn, KP, 2003) |
| "Malignant hyperthermia is a potentially fatal genetic myopathy that presents when the patient is under anesthesia." | 2.41 | Malignant hyperthermia: considerations for the general surgeon. ( Heggie, JE, 2002) |
| " The successful treatment is based on an early diagnosis, immediately interruption of triggering agents, intravenous administration of Dantrolene in sufficient dosage and starting of adequate symptomatic treatment." | 2.41 | [Malignant hyperthermia]. ( Ben Ammar, MS; Bouhajja, B; Haddad, F, 2002) |
| "Dantrolene was administered to treat the hypermetabolic manifestations in 20 minutes after the identification of MH." | 1.62 | A case report of malignant hyperthermia in a patient with myotonic dystrophy type I: A CARE-compliant article. ( Baek, SJ; Doo, AR; Kim, DC; Yoo, SW, 2021) |
| "Sporadic clinical episodes of malignant hyperthermia (MH) that develop during general anaesthesia (GA) have been reported in Singapore." | 1.46 | Malignant Hyperthermia and Ryanodine Receptor Type 1 Gene (RyR1) Mutation in a Family in Singapore. ( Lai, PS; Lee, DW; Lee, TL; Li, DW; Yong, RY, 2017) |
| "After achieving predefined malignant hyperthermia criteria, standardised therapy was initiated; dantrolene sodium suspension (5 mg kg(-1)) was administered and the injection was repeated after 24 min." | 1.39 | 3,4-Methylenedioxymethamphetamine induces a hyperthermic and hypermetabolic crisis in pigs with and without a genetic disposition for malignant hyperthermia. ( Becker, S; Gerbershagen, MU; Oldewurtel, C; Richard, A; Schäfer, U; Schütte, JK; Singler, P; Starosse, A; Wappler, F, 2013) |
| "Susceptibility to malignant hyperthermia is inherited as an autosomal dominant disorder and is associated with myopathies." | 1.33 | [Malignant hyperthermia--a hereditary and potentially life-threatening condition]. ( Aasly, J; Haugen, T; Müller, CR; Toft, M, 2005) |
| "Exertional heat illness (EHI) and malignant hyperthermia (MH) are two potentially lethal conditions." | 1.32 | Is there a link between malignant hyperthermia and exertional heat illness? ( Brandom, B; Bunger, R; Deuster, P; Muldoon, S, 2004) |
| "Many cases of early-onset inherited Alzheimer's disease (AD) are caused by mutations in the presenilin-1 (PS1) gene." | 1.31 | Presenilin-1 mutation increases neuronal vulnerability to focal ischemia in vivo and to hypoxia and glucose deprivation in cell culture: involvement of perturbed calcium homeostasis. ( Kindy, MS; Mattson, MP; Yu, J; Zhu, H, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (5.00) | 18.7374 |
| 1990's | 1 (5.00) | 18.2507 |
| 2000's | 11 (55.00) | 29.6817 |
| 2010's | 5 (25.00) | 24.3611 |
| 2020's | 2 (10.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kim, KSM | 1 |
| Kriss, RS | 1 |
| Tautz, TJ | 1 |
| Aldrich, K | 1 |
| Velez-Irizarry, D | 1 |
| Fenger, C | 1 |
| Schott, M | 1 |
| Valberg, SJ | 1 |
| Yoo, SW | 1 |
| Baek, SJ | 1 |
| Kim, DC | 1 |
| Doo, AR | 1 |
| Chen, W | 1 |
| Koop, A | 1 |
| Liu, Y | 1 |
| Guo, W | 1 |
| Wei, J | 1 |
| Wang, R | 1 |
| MacLennan, DH | 1 |
| Dirksen, RT | 1 |
| Chen, SRW | 1 |
| Li, DW | 1 |
| Lai, PS | 1 |
| Lee, DW | 1 |
| Yong, RY | 1 |
| Lee, TL | 1 |
| MacKay, EJ | 1 |
| Wilkerson, C | 1 |
| Kraeva, N | 1 |
| Rosenberg, H | 1 |
| Kennedy, T | 1 |
| Chen, X | 1 |
| Tang, TS | 1 |
| Tu, H | 1 |
| Nelson, O | 1 |
| Pook, M | 1 |
| Hammer, R | 1 |
| Nukina, N | 1 |
| Bezprozvanny, I | 1 |
| Stratman, RC | 1 |
| Flynn, JD | 1 |
| Hatton, KW | 1 |
| Schütte, JK | 1 |
| Schäfer, U | 1 |
| Becker, S | 1 |
| Oldewurtel, C | 1 |
| Starosse, A | 1 |
| Singler, P | 1 |
| Richard, A | 1 |
| Wappler, F | 2 |
| Gerbershagen, MU | 1 |
| Heggie, JE | 1 |
| Bouhajja, B | 1 |
| Haddad, F | 1 |
| Ben Ammar, MS | 1 |
| Glahn, KP | 1 |
| Sun, WZ | 1 |
| Yeh, HM | 1 |
| Muldoon, S | 1 |
| Deuster, P | 1 |
| Brandom, B | 1 |
| Bunger, R | 1 |
| Haugen, T | 1 |
| Toft, M | 1 |
| Müller, CR | 1 |
| Aasly, J | 1 |
| Newmark, JL | 1 |
| Voelkel, M | 1 |
| Brandom, BW | 1 |
| Wu, J | 1 |
| Owen, VJ | 1 |
| Taske, NL | 1 |
| Lamb, GD | 1 |
| Fiege, M | 1 |
| Antz, M | 1 |
| Schulte am Esch, J | 1 |
| Mattson, MP | 1 |
| Zhu, H | 1 |
| Yu, J | 1 |
| Kindy, MS | 1 |
| Haddad, FS | 1 |
6 reviews available for dantrolene and Genetic Predisposition
| Article | Year |
|---|---|
Malignant Hyperthermia: A Clinical Review.
Topics: Calcium Channels, L-Type; Calcium-Binding Proteins; Calsequestrin; Comorbidity; Dantrolene; Genetic | 2019 |
Malignant hyperthermia: a pharmacogenetic disorder.
Topics: Dantrolene; Genetic Predisposition to Disease; Humans; Malignant Hyperthermia; Muscle Relaxants, Cen | 2009 |
Malignant hyperthermia: considerations for the general surgeon.
Topics: Anesthetics, Inhalation; Biopsy; Dantrolene; General Surgery; Genetic Predisposition to Disease; Hum | 2002 |
[Malignant hyperthermia].
Topics: Anesthesia, General; Dantrolene; Diagnosis, Differential; Genetic Predisposition to Disease; Humans; | 2002 |
[Malignant hyperthermia].
Topics: Anesthetics, Inhalation; Dantrolene; Diagnosis, Differential; Genetic Predisposition to Disease; Hum | 2003 |
Malignant hyperthermia--a clinical review.
Topics: Calcium; Cell Membrane; Dantrolene; Genetic Predisposition to Disease; Humans; Malignant Hyperthermi | 1986 |
14 other studies available for dantrolene and Genetic Predisposition
| Article | Year |
|---|---|
Pathways of calcium regulation, electron transport, and mitochondrial protein translation are molecular signatures of susceptibility to recurrent exertional rhabdomyolysis in Thoroughbred racehorses.
Topics: Animals; Calcium; Dantrolene; Disease Susceptibility; Electron Transport; Female; Genetic Predisposi | 2021 |
A case report of malignant hyperthermia in a patient with myotonic dystrophy type I: A CARE-compliant article.
Topics: Adolescent; Anesthesia, General; Dantrolene; Genetic Predisposition to Disease; Genetic Testing; Hum | 2021 |
Reduced threshold for store overload-induced Ca
Topics: Adrenergic beta-Antagonists; Amino Acid Substitution; Animals; Calcium Signaling; Carbazoles; Carved | 2017 |
Malignant Hyperthermia and Ryanodine Receptor Type 1 Gene (RyR1) Mutation in a Family in Singapore.
Topics: Adult; Dantrolene; Female; Genetic Predisposition to Disease; Humans; Male; Malignant Hyperthermia; | 2017 |
A rare genetic variant of the ryanodine receptor in a suspected malignant hyperthermia susceptible patient.
Topics: Adolescent; Anesthesia, Intravenous; Blood Gas Analysis; Dantrolene; Genetic Predisposition to Disea | 2016 |
Deranged calcium signaling and neurodegeneration in spinocerebellar ataxia type 3.
Topics: Adult; Animals; Animals, Genetically Modified; Ataxin-3; Brain; Calcium Signaling; Cells, Cultured; | 2008 |
3,4-Methylenedioxymethamphetamine induces a hyperthermic and hypermetabolic crisis in pigs with and without a genetic disposition for malignant hyperthermia.
Topics: Acidosis; Animals; Dantrolene; Fatty Acids, Nonesterified; Fever; Genetic Predisposition to Disease; | 2013 |
When economy meets medicine--malignant hyperthermia in Taiwan.
Topics: Cost-Benefit Analysis; Dantrolene; Genetic Predisposition to Disease; Health Care Costs; Humans; Mal | 2004 |
Is there a link between malignant hyperthermia and exertional heat illness?
Topics: Acidosis; Adolescent; Child; Dantrolene; Fatal Outcome; Genetic Predisposition to Disease; Heat Exha | 2004 |
[Malignant hyperthermia--a hereditary and potentially life-threatening condition].
Topics: Adult; Dantrolene; Female; Genetic Predisposition to Disease; Genetic Testing; Humans; Male; Maligna | 2005 |
Delayed onset of malignant hyperthermia without creatine kinase elevation in a geriatric, ryanodine receptor type 1 gene compound heterozygous patient.
Topics: Aged; Anesthesia, General; Anesthetics, Inhalation; Antihypertensive Agents; Blood Pressure; Colosto | 2007 |
Reduced Mg2+ inhibition of Ca2+ release in muscle fibers of pigs susceptible to malignant hyperthermia.
Topics: Animals; Caffeine; Calcium; Calcium Channel Blockers; Dantrolene; Genetic Predisposition to Disease; | 1997 |
Hemodynamic and metabolic alterations in response to graded exercise in a patient susceptible to malignant hyperthermia.
Topics: Adult; Dantrolene; Exercise; Genetic Predisposition to Disease; Hemodynamics; Humans; Male; Malignan | 2000 |
Presenilin-1 mutation increases neuronal vulnerability to focal ischemia in vivo and to hypoxia and glucose deprivation in cell culture: involvement of perturbed calcium homeostasis.
Topics: Alzheimer Disease; Animals; Apoptosis; Blood Pressure; Calcium; Carbon Dioxide; Cell Hypoxia; Cells, | 2000 |