dantrolene has been researched along with Gaucher Disease in 1 studies
Dantrolene: Skeletal muscle relaxant that acts by interfering with excitation-contraction coupling in the muscle fiber. It is used in spasticity and other neuromuscular abnormalities. Although the mechanism of action is probably not central, dantrolene is usually grouped with the central muscle relaxants.
dantrolene : The hydrazone resulting from the formal condensation of 5-(4-nitrophenyl)furfural with 1-aminohydantoin. A ryanodine receptor antagonist used for the relief of chronic severe spasticity and malignant hyperthermia.
Gaucher Disease: An autosomal recessive disorder caused by a deficiency of acid beta-glucosidase (GLUCOSYLCERAMIDASE) leading to intralysosomal accumulation of glycosylceramide mainly in cells of the MONONUCLEAR PHAGOCYTE SYSTEM. The characteristic Gaucher cells, glycosphingolipid-filled HISTIOCYTES, displace normal cells in BONE MARROW and visceral organs causing skeletal deterioration, hepatosplenomegaly, and organ dysfunction. There are several subtypes based on the presence and severity of neurological involvement.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Dantrolene treatment partially normalized Ryr expression and its potential regulators, CAMK IV and calmodulin." | 5.43 | Modulating ryanodine receptors with dantrolene attenuates neuronopathic phenotype in Gaucher disease mice. ( Blackwood, R; Dasgupta, N; Fleming, S; Grabowski, GA; Inskeep, V; Li, R; Liou, B; Marshall, J; Peng, Y; Quinn, B; Setchell, KD; Sun, Y; Zhang, W, 2016) |
| "Dantrolene treatment partially normalized Ryr expression and its potential regulators, CAMK IV and calmodulin." | 1.43 | Modulating ryanodine receptors with dantrolene attenuates neuronopathic phenotype in Gaucher disease mice. ( Blackwood, R; Dasgupta, N; Fleming, S; Grabowski, GA; Inskeep, V; Li, R; Liou, B; Marshall, J; Peng, Y; Quinn, B; Setchell, KD; Sun, Y; Zhang, W, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Liou, B | 1 |
| Peng, Y | 1 |
| Li, R | 1 |
| Inskeep, V | 1 |
| Zhang, W | 1 |
| Quinn, B | 1 |
| Dasgupta, N | 1 |
| Blackwood, R | 1 |
| Setchell, KD | 1 |
| Fleming, S | 1 |
| Grabowski, GA | 1 |
| Marshall, J | 1 |
| Sun, Y | 1 |
1 other study available for dantrolene and Gaucher Disease
| Article | Year |
|---|---|
Modulating ryanodine receptors with dantrolene attenuates neuronopathic phenotype in Gaucher disease mice.
Topics: Animals; Calcium Signaling; Dantrolene; Disease Models, Animal; Gaucher Disease; Humans; Mice; Mitoc | 2016 |