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dantrolene and Flaccid Quadriplegia

dantrolene has been researched along with Flaccid Quadriplegia in 7 studies

Dantrolene: Skeletal muscle relaxant that acts by interfering with excitation-contraction coupling in the muscle fiber. It is used in spasticity and other neuromuscular abnormalities. Although the mechanism of action is probably not central, dantrolene is usually grouped with the central muscle relaxants.
dantrolene : The hydrazone resulting from the formal condensation of 5-(4-nitrophenyl)furfural with 1-aminohydantoin. A ryanodine receptor antagonist used for the relief of chronic severe spasticity and malignant hyperthermia.

Research Excerpts

ExcerptRelevanceReference
"To describe a new case of eosinophilic pleural effusion induced by dantrolene chronic administration."8.82Dantrolene and pleural effusion: case report and review of literature. ( Calmels, P; Fayolle-Minon, I; Gautheron, V; Lê-Quang, B; Valayer-Chaléat, E, 2004)
"A 29-year-old man with C6 tetraplegia (ASIA A) using an implanted baclofen pump and intrathecal catheter infusion system for spasticity control developed severe spasticity, hyperthermia, hypotension, rhabdomyolysis, and disseminated intravascular coagulation after catheter disconnection."7.70Hyperthermia, rhabdomyolysis, and disseminated intravascular coagulation associated with baclofen pump catheter failure. ( Christopherson, MW; Reeves, RK; Stolp-Smith, KA, 1998)
"A quadriplegic patient with severe spasticity, treated with dantrolene (400 mg daily) for 5 years, had dyspnea, orthopnea, hypoxia, and right-sided opacity of the chest on radiograph."5.31Eosinophilic pleural effusion due to dantrolene: resolution with steroid therapy. ( Felz, MW; Haviland-Foley, DJ, 2001)
"To describe a new case of eosinophilic pleural effusion induced by dantrolene chronic administration."4.82Dantrolene and pleural effusion: case report and review of literature. ( Calmels, P; Fayolle-Minon, I; Gautheron, V; Lê-Quang, B; Valayer-Chaléat, E, 2004)
"A 29-year-old man with C6 tetraplegia (ASIA A) using an implanted baclofen pump and intrathecal catheter infusion system for spasticity control developed severe spasticity, hyperthermia, hypotension, rhabdomyolysis, and disseminated intravascular coagulation after catheter disconnection."3.70Hyperthermia, rhabdomyolysis, and disseminated intravascular coagulation associated with baclofen pump catheter failure. ( Christopherson, MW; Reeves, RK; Stolp-Smith, KA, 1998)
"A patient with C6D tetraplegia who sustained intoxication because of drug interaction is presented."1.33Carbamazepine toxicity following Oxybutynin and Dantrolene administration: a case report. ( Bluvstein, V; Catz, A; Odi, H; Ronen, J; Vander, T, 2005)
"A quadriplegic patient with severe spasticity, treated with dantrolene (400 mg daily) for 5 years, had dyspnea, orthopnea, hypoxia, and right-sided opacity of the chest on radiograph."1.31Eosinophilic pleural effusion due to dantrolene: resolution with steroid therapy. ( Felz, MW; Haviland-Foley, DJ, 2001)

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19902 (28.57)18.7374
1990's2 (28.57)18.2507
2000's3 (42.86)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Lê-Quang, B1
Calmels, P1
Valayer-Chaléat, E1
Fayolle-Minon, I1
Gautheron, V1
Vander, T1
Odi, H1
Bluvstein, V1
Ronen, J1
Catz, A1
Gilman, TM1
Segal, JL1
Brunnemann, SR1
Reeves, RK1
Stolp-Smith, KA1
Christopherson, MW1
Felz, MW1
Haviland-Foley, DJ1
Pinder, RM1
Brogden, RN1
Speight, TM1
Avery, GS1
van Laere, M1
Leus, P1
Mastelinck, C1

Reviews

2 reviews available for dantrolene and Flaccid Quadriplegia

ArticleYear
Dantrolene and pleural effusion: case report and review of literature.
    Spinal cord, 2004, Volume: 42, Issue:5

    Topics: Dantrolene; Female; Humans; Middle Aged; Muscle Relaxants, Central; Muscle, Skeletal; Nitrofurantoin

2004
Dantrolene sodium: a review of its pharmacological properties and therapeutic efficacy in spasticity.
    Drugs, 1977, Volume: 13, Issue:1

    Topics: Adult; Animals; Cats; Cerebral Palsy; Chemical and Drug Induced Liver Injury; Child; Clinical Trials

1977

Trials

2 trials available for dantrolene and Flaccid Quadriplegia

ArticleYear
Metoclopramide increases the bioavailability of dantrolene in spinal cord injury.
    Journal of clinical pharmacology, 1996, Volume: 36, Issue:1

    Topics: Administration, Oral; Adult; Biological Availability; Cross-Over Studies; Dantrolene; Dopamine Antag

1996
Dantrolene sodium: a review of its pharmacological properties and therapeutic efficacy in spasticity.
    Drugs, 1977, Volume: 13, Issue:1

    Topics: Adult; Animals; Cats; Cerebral Palsy; Chemical and Drug Induced Liver Injury; Child; Clinical Trials

1977

Other Studies

4 other studies available for dantrolene and Flaccid Quadriplegia

ArticleYear
Carbamazepine toxicity following Oxybutynin and Dantrolene administration: a case report.
    Spinal cord, 2005, Volume: 43, Issue:4

    Topics: Adult; Analgesics, Non-Narcotic; Carbamazepine; Dantrolene; Dizziness; Drug Interactions; Drug Thera

2005
Hyperthermia, rhabdomyolysis, and disseminated intravascular coagulation associated with baclofen pump catheter failure.
    Archives of physical medicine and rehabilitation, 1998, Volume: 79, Issue:3

    Topics: Adult; Baclofen; Catheters, Indwelling; Dantrolene; Disseminated Intravascular Coagulation; Equipmen

1998
Eosinophilic pleural effusion due to dantrolene: resolution with steroid therapy.
    Southern medical journal, 2001, Volume: 94, Issue:5

    Topics: Adult; Anti-Inflammatory Agents; Dantrolene; Drug Hypersensitivity; Eosinophilia; Humans; Male; Musc

2001
[Effect of Dantrium on spasticity in paraplegic and tetraplegic patients (author's transl)].
    Journal belge de medecine physique et de rehabilitation. = Belgisch tijdschrift voor fysische geneeskunde en rehabilitatie, 1978, Volume: 1, Issue:2

    Topics: Adolescent; Adult; Dantrolene; Drug Evaluation; Drug Tolerance; Female; Humans; Male; Middle Aged; M

1978