dantrolene has been researched along with Disease Models, Animal in 83 studies
Dantrolene: Skeletal muscle relaxant that acts by interfering with excitation-contraction coupling in the muscle fiber. It is used in spasticity and other neuromuscular abnormalities. Although the mechanism of action is probably not central, dantrolene is usually grouped with the central muscle relaxants.
dantrolene : The hydrazone resulting from the formal condensation of 5-(4-nitrophenyl)furfural with 1-aminohydantoin. A ryanodine receptor antagonist used for the relief of chronic severe spasticity and malignant hyperthermia.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Stabilizing RyR with chronic dantrolene treatment does not affect hypertension development in SHR." | 7.96 | Chronic Dantrolene Treatment Does Not Affect Hypertension, but Attenuates Sympathetic Stimulation Enhanced Atrial Fibrillation Inducibility in SHR. ( Gerdes, AM; Greco, L; Lee, JS; Li, Y; Migirov, A; Zhang, Y, 2020) |
| "To evaluate the possible neuroprotective effects of ketamine and dantrolene on the hippocampal apoptosis and spatial learning in rats exposed to repeated electroconvulsive seizures (ECS) as a model of status epilepticus (SE)." | 7.96 | Investigation of the Possible Protective Effects of Ketamine and Dantrolene on the Hippocampal Apoptosis and Spatial Learning in Rats Exposed to Repeated Electroconvulsive Seizures as a Model of Status Epilepticus. ( Atilla, P; Barun, S; Canpinar, H; Erdem, SR; Ertunc, M; Gursoy, ID; Keskin, U; Kiziltas, M; Muftuoglu, S; Narin, F; Sara, Y; Yuce, D, 2020) |
| "It was concluded that dantrolene applied after ischemia might help protect the spinal cord against ischemia/reperfusion injury." | 7.74 | Can dantrolene protect spinal cord against ischemia/reperfusion injury? An experimental study. ( Aslan, A; Ayva, E; Buyukokuroglu, ME; Cekirdekci, A; Cemek, M; Demirkan, I; Emmiler, M; Kocogullari, CU; Sahin, O; Tur, L, 2008) |
| "The aims of our study were to assess whether the increased oxidative stress in experimental otitis media with effusion (OME) induced by histamine was reflected erythrocytes and middle ear effusion fluid by lipid peroxidation; to survey the alterations in antioxidant enzyme activities in experimental OME; and to determine the effect of dantrolene on this oxidative stress." | 7.73 | Effect of dantrolene on lipid peroxidation, lutathione and glutathione-dependent enzyme activities in experimental otitis media with effusion in guinea pigs. ( Aktan, B; Buyukokuroglu, ME; Elmastas, M; Taysi, S; Ucuncu, H, 2005) |
| "To clarify the role of nitric oxide (NO) in the pathogenesis of seizures in susceptible EL mice, we investigated effects of three drugs potentially related to NO production, MK-801, dantrolene, and FK506, on convulsive seizures and brain NO metabolites (NOx)." | 7.71 | Effects of MK-801, dantrolene, and FK506 on convulsive seizures and brain nitric oxide production in seizure-susceptible EL mice. ( Akasaki, Y; Hashiguchi, W; Nagatomo, I; Takigawa, M; Tominaga, M; Uchida, M, 2001) |
| "Several authors have shown that dantrolene may be effective in the treatment of heat stroke patients." | 7.70 | Dantrolene and recovery from heat stroke. ( Epstein, Y; Horowitz, M; Moran, D; Wiener, M, 1999) |
| " Experimental rabbits treated with haloperidol (1 mg/kg) by intramuscular injection, were studied for the diagnostic symptoms of increased muscle rigidity, elevated body temperature, and high serum creatine phosphokinase (CPK) level." | 7.69 | Development of an animal model for neuroleptic malignant syndrome: heat-exposed rabbits with haloperidol and atropine administration exhibit increased muscle activity, hyperthermia, and high serum creatine phosphokinase level. ( Hosono, T; Ikura, Y; Kudo, T; Niigawa, H; Nishimura, T; Sakamoto, S; Takeda, M; Taniguchi, N; Tanii, H, 1996) |
| "Therapeutic interventions with conventional cooling or conventional cooling and dantrolene provided significant improvement in cardiovascular function in an immature porcine heatstroke model." | 7.69 | Effects of dantrolene on cooling times and cardiovascular parameters in an immature porcine model of heatstroke. ( Conway, EE; Rubin, DH; Singer, LP; Zuckerman, GB, 1997) |
| "We conclude that dantrolene decreases survival in bacterial sepsis and has no effect on survival in endotoxemia in rats." | 7.69 | Dantrolene, an inhibitor of intracellular calcium release, fails to increase survival in a rat model of intra-abdominal sepsis. ( Cameron, EM; Fink, MP; Menconi, MJ; Phipps, R; Zhuang, J, 1996) |
| "Dantrolene sodium has been compared with reference antiarrhythmic agents in rodent models of cardiac arrhythmia." | 7.67 | Effects of dantrolene sodium in rodent models of cardiac arrhythmia. ( Brooks, RR; Carpenter, JF; Gregory, CM; Jones, SM, 1989) |
| "Experimental autoimmune myasthenia gravis in rats was treated with dantrolene sodium (20 mg/kg/day) from 18th to 34th postinoculation day." | 7.66 | Therapeutic approach to experimental autoimmune myasthenia gravis by dantrolene sodium. ( Matsubara, S; Okumura, S; Sakato, S; Takamori, M, 1983) |
| "Dantrolene is a ryanodine receptor blocker that is used clinically for treatment of malignant hyperthermia." | 5.72 | Dantrolene reduces platelet-derived growth factor (PDGF)-induced vascular smooth muscle cell proliferation and neointimal formation following vascular injury in mice. ( Akase, H; Inamitsu, M; Kobayashi, S; Mikawa, M; Nakamura, Y; Oda, T; Okamura, T; Sakai, C; Suetomi, T; Tominaga, N; Uchida, T; Yamamoto, T; Yano, M, 2022) |
| "Dantrolene treatment partially normalized Ryr expression and its potential regulators, CAMK IV and calmodulin." | 5.43 | Modulating ryanodine receptors with dantrolene attenuates neuronopathic phenotype in Gaucher disease mice. ( Blackwood, R; Dasgupta, N; Fleming, S; Grabowski, GA; Inskeep, V; Li, R; Liou, B; Marshall, J; Peng, Y; Quinn, B; Setchell, KD; Sun, Y; Zhang, W, 2016) |
| "Acute pancreatitis is a painful, inflammatory disorder for which adequate treatments are lacking." | 5.36 | Dantrolene mitigates caerulein-induced pancreatitis in vivo in mice. ( Ahmad, MU; Bhandari, V; Choo-Wing, R; Husain, SZ; Jain, D; Orabi, AI; Parness, J; Shah, AU, 2010) |
| "Dantrolene has an inhibitory action against Ca(2+) release from intracellular Ca(2+) stores." | 5.33 | Dantrolene, a calcium-induced calcium release inhibitor, prevents the acquisition of amygdaloid kindling in rats, a model of experimental epilepsy. ( Sakai, T; Yoshida, M, 2006) |
| " It also has antiarrhythmic properties and may thus be an alternative to amiodarone for the treatment of ventricular fibrillation (VF)." | 5.24 | Dantrolene versus amiodarone for cardiopulmonary resuscitation: a randomized, double-blinded experimental study. ( Dersch, W; Eschbach, D; Feldmann, C; Freitag, D; Irqsusi, M; Steinfeldt, T; Wiesmann, T; Wulf, H, 2017) |
| "Here, we aimed to investigate whether direct pharmacological intervention in the RV muscle with dantrolene (DAN), a stabilizer of the cardiac ryanodine receptor (RyR2), has a protective effect against RV dysfunction and arrhythmia in a monocrotaline (MCT)-induced PAH rat model." | 4.12 | Stabilization of RyR2 maintains right ventricular function, reduces the development of ventricular arrhythmias, and improves prognosis in pulmonary hypertension. ( Fujii, S; Fukuda, M; Kato, T; Kobayashi, S; Mikawa, M; Nakamura, Y; Nawata, J; Oda, T; Okamura, T; Okuda, S; Suetomi, T; Tanaka, S; Uchinoumi, H; Yamamoto, T; Yano, M, 2022) |
| "Stabilizing RyR with chronic dantrolene treatment does not affect hypertension development in SHR." | 3.96 | Chronic Dantrolene Treatment Does Not Affect Hypertension, but Attenuates Sympathetic Stimulation Enhanced Atrial Fibrillation Inducibility in SHR. ( Gerdes, AM; Greco, L; Lee, JS; Li, Y; Migirov, A; Zhang, Y, 2020) |
| "To evaluate the possible neuroprotective effects of ketamine and dantrolene on the hippocampal apoptosis and spatial learning in rats exposed to repeated electroconvulsive seizures (ECS) as a model of status epilepticus (SE)." | 3.96 | Investigation of the Possible Protective Effects of Ketamine and Dantrolene on the Hippocampal Apoptosis and Spatial Learning in Rats Exposed to Repeated Electroconvulsive Seizures as a Model of Status Epilepticus. ( Atilla, P; Barun, S; Canpinar, H; Erdem, SR; Ertunc, M; Gursoy, ID; Keskin, U; Kiziltas, M; Muftuoglu, S; Narin, F; Sara, Y; Yuce, D, 2020) |
| "It was concluded that dantrolene applied after ischemia might help protect the spinal cord against ischemia/reperfusion injury." | 3.74 | Can dantrolene protect spinal cord against ischemia/reperfusion injury? An experimental study. ( Aslan, A; Ayva, E; Buyukokuroglu, ME; Cekirdekci, A; Cemek, M; Demirkan, I; Emmiler, M; Kocogullari, CU; Sahin, O; Tur, L, 2008) |
| "The aims of our study were to assess whether the increased oxidative stress in experimental otitis media with effusion (OME) induced by histamine was reflected erythrocytes and middle ear effusion fluid by lipid peroxidation; to survey the alterations in antioxidant enzyme activities in experimental OME; and to determine the effect of dantrolene on this oxidative stress." | 3.73 | Effect of dantrolene on lipid peroxidation, lutathione and glutathione-dependent enzyme activities in experimental otitis media with effusion in guinea pigs. ( Aktan, B; Buyukokuroglu, ME; Elmastas, M; Taysi, S; Ucuncu, H, 2005) |
| "The present study investigated whether dantrolene, which inhibits the Ca(2+) release from the intracellular Ca(2+) store sites, reduced nuclear DNA fragmentation and produced neuronal protection in a model of global forebrain ischemia." | 3.71 | Dantrolene ameliorates delayed cell death and concomitant DNA fragmentation in the rat hippocampal CA1 neurons subjected to mild ischemia. ( Imaizumi, T; Nakayama, R; Terasaki, H; Ushijima, K; Yano, T, 2001) |
| "To clarify the role of nitric oxide (NO) in the pathogenesis of seizures in susceptible EL mice, we investigated effects of three drugs potentially related to NO production, MK-801, dantrolene, and FK506, on convulsive seizures and brain NO metabolites (NOx)." | 3.71 | Effects of MK-801, dantrolene, and FK506 on convulsive seizures and brain nitric oxide production in seizure-susceptible EL mice. ( Akasaki, Y; Hashiguchi, W; Nagatomo, I; Takigawa, M; Tominaga, M; Uchida, M, 2001) |
| "5, 5 and 10 mg kg (-1)) was investigated and compared with diclofenac sodium (5 mg kg (-1)) using the formalin-, histamine-, and carrageenan-induced paw oedema and cotton pellet granuloma tests." | 3.71 | Anti-inflammatory and antinociceptive properties of dantrolene sodium in rats and mice. ( Büyükokuroğlu, ME, 2002) |
| "Several authors have shown that dantrolene may be effective in the treatment of heat stroke patients." | 3.70 | Dantrolene and recovery from heat stroke. ( Epstein, Y; Horowitz, M; Moran, D; Wiener, M, 1999) |
| "Therapeutic interventions with conventional cooling or conventional cooling and dantrolene provided significant improvement in cardiovascular function in an immature porcine heatstroke model." | 3.69 | Effects of dantrolene on cooling times and cardiovascular parameters in an immature porcine model of heatstroke. ( Conway, EE; Rubin, DH; Singer, LP; Zuckerman, GB, 1997) |
| "We report the effects of two new dihydropyridine derivatives, isradipine (4-(4'-benzofurazanyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedic arboxylic acid methylisopropylester) and niguldipine (1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinecarboxylic acid 3-(4,4-diphenyl-1-piperidinyl)-propyl methyl ester hydrochloride), and of dantrolene (1-[(5-[p-nitrophenyl]furfurylidene)-amino]hydantoin sodium, an inhibitor of Ca2+ release from intracellular stores) on the protective efficacy of antiepileptic drugs against maximal electroshock-induced seizures." | 3.69 | Influence of isradipine, niguldipine and dantrolene on the anticonvulsive action of conventional antiepileptics in mice. ( Borowicz, KK; Czuczwar, SJ; Gasior, M; Kleinrok, Z, 1997) |
| " Experimental rabbits treated with haloperidol (1 mg/kg) by intramuscular injection, were studied for the diagnostic symptoms of increased muscle rigidity, elevated body temperature, and high serum creatine phosphokinase (CPK) level." | 3.69 | Development of an animal model for neuroleptic malignant syndrome: heat-exposed rabbits with haloperidol and atropine administration exhibit increased muscle activity, hyperthermia, and high serum creatine phosphokinase level. ( Hosono, T; Ikura, Y; Kudo, T; Niigawa, H; Nishimura, T; Sakamoto, S; Takeda, M; Taniguchi, N; Tanii, H, 1996) |
| "We conclude that dantrolene decreases survival in bacterial sepsis and has no effect on survival in endotoxemia in rats." | 3.69 | Dantrolene, an inhibitor of intracellular calcium release, fails to increase survival in a rat model of intra-abdominal sepsis. ( Cameron, EM; Fink, MP; Menconi, MJ; Phipps, R; Zhuang, J, 1996) |
| "Dantrolene sodium has been compared with reference antiarrhythmic agents in rodent models of cardiac arrhythmia." | 3.67 | Effects of dantrolene sodium in rodent models of cardiac arrhythmia. ( Brooks, RR; Carpenter, JF; Gregory, CM; Jones, SM, 1989) |
| "Experimental autoimmune myasthenia gravis in rats was treated with dantrolene sodium (20 mg/kg/day) from 18th to 34th postinoculation day." | 3.66 | Therapeutic approach to experimental autoimmune myasthenia gravis by dantrolene sodium. ( Matsubara, S; Okumura, S; Sakato, S; Takamori, M, 1983) |
| "Malignant hyperthermia is a serious anesthetic complication, presenting with various manifestations, with high mortality and morbidity." | 2.40 | [Malignant hyperthermia]. ( Bracco, D; Chastonay, P; Freymond, D; Ravussin, P, 1999) |
| "Anesthetic-induced malignant hyperthermia (MH) originally attracted scientific interest because of the associated high fatality rate." | 2.36 | Malignant hyperthermia: responses of skeletal muscles to general anesthetics. ( Ahern, CP; Gallant, EM, 1983) |
| "Dantrolene is a ryanodine receptor blocker that is used clinically for treatment of malignant hyperthermia." | 1.72 | Dantrolene reduces platelet-derived growth factor (PDGF)-induced vascular smooth muscle cell proliferation and neointimal formation following vascular injury in mice. ( Akase, H; Inamitsu, M; Kobayashi, S; Mikawa, M; Nakamura, Y; Oda, T; Okamura, T; Sakai, C; Suetomi, T; Tominaga, N; Uchida, T; Yamamoto, T; Yano, M, 2022) |
| "Dantrolene treatment had no significant change in the amyloid burden or synaptic proteins and no significant side effects on mortality, olfaction, motor, or liver functions in 5XFAD mice." | 1.56 | Intranasal Dantrolene as a Disease-Modifying Drug in Alzheimer 5XFAD Mice. ( Ben Abou, M; Eckenhoff, MF; Gao, X; Hepner, A; Liang, G; Meng, Q; Shi, Y; Wei, H; Zhang, J; Zhang, L, 2020) |
| "Dantrolene treatment partially normalized Ryr expression and its potential regulators, CAMK IV and calmodulin." | 1.43 | Modulating ryanodine receptors with dantrolene attenuates neuronopathic phenotype in Gaucher disease mice. ( Blackwood, R; Dasgupta, N; Fleming, S; Grabowski, GA; Inskeep, V; Li, R; Liou, B; Marshall, J; Peng, Y; Quinn, B; Setchell, KD; Sun, Y; Zhang, W, 2016) |
| "LPS-infused rats had significant memory deficits in the Morris water maze, and this deficit was ameliorated by treatment with nimodipine." | 1.42 | Calcium dysregulation via L-type voltage-dependent calcium channels and ryanodine receptors underlies memory deficits and synaptic dysfunction during chronic neuroinflammation. ( Adzovic, L; Crockett, AM; D'Angelo, HM; Hopp, SC; Kaercher, RM; Royer, SE; Wenk, GL, 2015) |
| " Compared with the control group, chronic administration of ISO significantly increased APD, the maximum slope (Smax) of APDR curve, and the spatial dispersions of Smax and APD (all P < ." | 1.42 | Effects of Dantrolene Treatment on Ventricular Electrophysiology and Arrhythmogenesis in Rats With Chronic β-Adrenergic Receptor Activation. ( Huang, CX; Liu, T; Qin, M; Shi, SB, 2015) |
| "In the groups with spinal cord trauma, the positive control group (PC) was given no treatment, the MS group was treated with methylprednisolone, the MS/DS group was treated with methylprednisolone and dantrolene, and the DS group was treated with dantrolene alone." | 1.40 | Effects of methylprednisolone, dantrolene, and their combination on experimental spinal cord injury. ( Alves, EG; Caldeira, FM; Costa, PM; Fukushima, FB; Lavor, MS; Melo, EG; Oliveira, KM; Rosado, IR; Silva, CM, 2014) |
| "Dantrolene treatment for 11 months significantly reduced both memory deficits and amyloid plaque load in the hippocampus in 13-month-old 3xTg-AD mice." | 1.38 | Dantrolene ameliorates cognitive decline and neuropathology in Alzheimer triple transgenic mice. ( Eckenhoff, MF; Inan, S; Joseph, DJ; Liang, G; Meng, Q; Peng, J; Peng, Y; Wei, H; Wu, Z, 2012) |
| "Dantrolene has been shown to be neuroprotective by reducing neuronal apoptosis after SCI." | 1.37 | The ameliorating effect of dantrolene on the morphology of urinary bladder in spinal cord injured rats. ( Caldeira, F; Gomes, M; Melo, E; Serakides, R; Torres, B, 2011) |
| "Halothane was discontinued after the administration of 0." | 1.37 | Comparison of the therapeutic effectiveness of a dantrolene sodium solution and a novel nanocrystalline suspension of dantrolene sodium in malignant hyperthermia normal and susceptible pigs. ( Becker, S; Burmester, S; Gerbershagen, MU; Kröner, L; Lenz, D; Schütte, JK; Starosse, A; Wappler, F, 2011) |
| "Alcohol abuse is a leading cause of pancreatitis, accounting for 30% of acute cases and 70-90% of chronic cases, yet the mechanisms leading to alcohol-associated pancreatic injury are unclear." | 1.37 | Ethanol enhances carbachol-induced protease activation and accelerates Ca2+ waves in isolated rat pancreatic acini. ( Ahmad, A; Husain, SZ; Luo, Y; Mahmood, SM; Muili, K; Orabi, AI; Reed, A; Shah, AU, 2011) |
| "Pre-treatment with dantrolene protected YAC128 MSNs from glutamate excitotoxicty, with an effective concentration of 100 nM and above." | 1.37 | Dantrolene is neuroprotective in Huntington's disease transgenic mouse model. ( Bezprozvanny, I; Chen, X; Herndon, E; Lvovskaya, S; Supnet, C; Wu, J, 2011) |
| "Pre-treatment with dantrolene (for 7-10 days) significantly inhibited the inducible VT (P<0." | 1.36 | Dantrolene, a therapeutic agent for malignant hyperthermia, inhibits catecholaminergic polymorphic ventricular tachycardia in a RyR2(R2474S/+) knock-in mouse model. ( Doi, M; Kobayashi, S; Matsuzaki, M; Oda, T; Okuda, S; Ono, M; Suetomi, T; Susa, T; Tateishi, H; Uchinoumi, H; Xu, X; Yamamoto, T; Yano, M, 2010) |
| "Instead, anoxia Ca(2+)-dependently activated various small/intermediate-conductance K(+) channels in WT neurons, which was less evident in Mecp2(-/y) neurons." | 1.36 | Impaired hippocampal Ca2+ homeostasis and concomitant K+ channel dysfunction in a mouse model of Rett syndrome during anoxia. ( Kron, M; Müller, M, 2010) |
| "Acute pancreatitis is a painful, inflammatory disorder for which adequate treatments are lacking." | 1.36 | Dantrolene mitigates caerulein-induced pancreatitis in vivo in mice. ( Ahmad, MU; Bhandari, V; Choo-Wing, R; Husain, SZ; Jain, D; Orabi, AI; Parness, J; Shah, AU, 2010) |
| "Paclitaxel treatment resulted in a peripheral neuropathy that affected the two hindpaws." | 1.35 | Different antinociceptive effects of botulinum toxin type A in inflammatory and peripheral polyneuropathic rat models. ( Auguet, M; Chabrier, PE; Favre-Guilmard, C, 2009) |
| "The type and mechanisms of these arrhythmias have never been explored and were the aim of the present work." | 1.35 | Increased intracellular Ca2+ and SR Ca2+ load contribute to arrhythmias after acidosis in rat heart. Role of Ca2+/calmodulin-dependent protein kinase II. ( Becerra, R; Copello, JA; Dedman, JR; Diaz-Sylvester, PL; Kaetzel, MA; Mattiazzi, A; Mundiña-Weilenmann, C; Palomeque, J; Rinaldi, G; Said, M; Vittone, L, 2008) |
| "Dantrolene has an inhibitory action against Ca(2+) release from intracellular Ca(2+) stores." | 1.33 | Dantrolene, a calcium-induced calcium release inhibitor, prevents the acquisition of amygdaloid kindling in rats, a model of experimental epilepsy. ( Sakai, T; Yoshida, M, 2006) |
| "Dantrolene, at 5 mg/kg, was useful to obtain significant protective effects, while the protector effect of higher dantrolene dosing level (10 mg/kg) was weak or absent." | 1.32 | Prevention of acute adriamycin cardiotoxicity by dantrolene in rats. ( Bakan, E; Buyukavci, M; Büyükokuroğlu, ME; Taysi, S, 2004) |
| "Pretreatment with propranolol (10 mg/kg), a 5-HT(1A) receptor antagonist as well as a beta-blocker, and dantrolene (20 mg/kg), a peripheral muscle relaxant, did not prevent the death of the animals, even though these two drugs suppressed the increase in rectal temperature to some extent." | 1.31 | Potent serotonin (5-HT)(2A) receptor antagonists completely prevent the development of hyperthermia in an animal model of the 5-HT syndrome. ( Katoh, S; Nisijima, K; Yoshino, T; Yui, K, 2001) |
| " To determine if dantrolene is safe to use in sepsis, two studies were performed." | 1.28 | Is dantrolene safe to administer in sepsis? The effect of dantrolene after endotoxin administration in dogs and rats. ( Beebe, DS; Belani, KG; Gillingham, K; Komanduri, V; Palahniuk, RJ; Sweeney, MF; Tuohy, SE, 1991) |
| "This situation may be similar to that in malignant hyperpyrexia (MH) occurring in mammals." | 1.26 | The chick as a model for malignant hyperpyrexia. ( Korczyn, AD; Shavit, S; Shlosberg, I, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (13.25) | 18.7374 |
| 1990's | 11 (13.25) | 18.2507 |
| 2000's | 20 (24.10) | 29.6817 |
| 2010's | 34 (40.96) | 24.3611 |
| 2020's | 7 (8.43) | 2.80 |
| Authors | Studies |
|---|---|
| Tanaka, S | 1 |
| Yamamoto, T | 5 |
| Mikawa, M | 2 |
| Nawata, J | 1 |
| Fujii, S | 1 |
| Nakamura, Y | 2 |
| Kato, T | 1 |
| Fukuda, M | 1 |
| Suetomi, T | 5 |
| Uchinoumi, H | 5 |
| Oda, T | 5 |
| Okuda, S | 4 |
| Okamura, T | 2 |
| Kobayashi, S | 5 |
| Yano, M | 5 |
| Sakai, C | 1 |
| Uchida, T | 1 |
| Akase, H | 1 |
| Tominaga, N | 1 |
| Inamitsu, M | 1 |
| Mustaly-Kalimi, S | 3 |
| Gallegos, W | 3 |
| Marr, RA | 3 |
| Gilman-Sachs, A | 3 |
| Peterson, DA | 3 |
| Sekler, I | 3 |
| Stutzmann, GE | 4 |
| Keles, I | 1 |
| Bozkurt, MF | 1 |
| Aglamis, E | 1 |
| Fidan, AF | 1 |
| Ceylan, C | 1 |
| Karalar, M | 1 |
| Coban, S | 1 |
| Denk, B | 1 |
| Buyukokuroglu, ME | 7 |
| Lee, JS | 1 |
| Greco, L | 1 |
| Migirov, A | 1 |
| Li, Y | 2 |
| Gerdes, AM | 2 |
| Zhang, Y | 2 |
| Shi, Y | 1 |
| Zhang, L | 1 |
| Gao, X | 1 |
| Zhang, J | 1 |
| Ben Abou, M | 1 |
| Liang, G | 2 |
| Meng, Q | 2 |
| Hepner, A | 1 |
| Eckenhoff, MF | 2 |
| Wei, H | 2 |
| Gursoy, ID | 1 |
| Barun, S | 1 |
| Erdem, SR | 1 |
| Keskin, U | 1 |
| Kiziltas, M | 1 |
| Atilla, P | 1 |
| Muftuoglu, S | 1 |
| Yuce, D | 1 |
| Narin, F | 1 |
| Ertunc, M | 1 |
| Sara, Y | 1 |
| Canpinar, H | 1 |
| Dai, B | 1 |
| Ma, X | 1 |
| Tang, Y | 1 |
| Xu, L | 1 |
| Guo, S | 1 |
| Chen, X | 3 |
| Lu, S | 1 |
| Wang, G | 1 |
| Liu, Y | 1 |
| Frommeyer, G | 1 |
| Krawczyk, J | 1 |
| Ellermann, C | 1 |
| Bögeholz, N | 1 |
| Kochhäuser, S | 1 |
| Dechering, DG | 1 |
| Fehr, M | 1 |
| Eckardt, L | 1 |
| Delfiner, MS | 1 |
| Nofi, C | 1 |
| Degovics, D | 1 |
| Hartmann, P | 1 |
| Németh, IB | 1 |
| Árva-Nagy, N | 1 |
| Kaszonyi, E | 1 |
| Szél, E | 1 |
| Strifler, G | 1 |
| Bende, B | 1 |
| Krenács, L | 1 |
| Kemény, L | 1 |
| Erős, G | 1 |
| Zamiri, N | 1 |
| Massé, S | 1 |
| Ramadeen, A | 1 |
| Kusha, M | 1 |
| Hu, X | 1 |
| Azam, MA | 1 |
| Liu, J | 1 |
| Lai, PF | 1 |
| Vigmond, EJ | 1 |
| Boyle, PM | 1 |
| Behradfar, E | 1 |
| Al-Hesayen, A | 1 |
| Waxman, MB | 1 |
| Backx, P | 1 |
| Dorian, P | 1 |
| Nanthakumar, K | 1 |
| Ma, L | 1 |
| Chai, J | 1 |
| Chu, W | 1 |
| Duan, H | 1 |
| Li, D | 1 |
| Yu, Y | 1 |
| Rosado, IR | 1 |
| Lavor, MS | 1 |
| Alves, EG | 1 |
| Fukushima, FB | 1 |
| Oliveira, KM | 1 |
| Silva, CM | 1 |
| Caldeira, FM | 1 |
| Costa, PM | 1 |
| Melo, EG | 1 |
| Kurokawa, K | 2 |
| Mizuno, K | 2 |
| Ohkuma, S | 2 |
| Liu, T | 1 |
| Shi, SB | 1 |
| Qin, M | 1 |
| Huang, CX | 1 |
| Hopp, SC | 1 |
| D'Angelo, HM | 1 |
| Royer, SE | 1 |
| Kaercher, RM | 1 |
| Crockett, AM | 1 |
| Adzovic, L | 1 |
| Wenk, GL | 1 |
| Yang, Y | 1 |
| Li, N | 1 |
| Alsina, KM | 1 |
| Puglisi, JL | 1 |
| Chen-Izu, Y | 1 |
| Cornea, RL | 1 |
| Wehrens, XHT | 1 |
| Bers, DM | 1 |
| Liou, B | 1 |
| Peng, Y | 2 |
| Li, R | 1 |
| Inskeep, V | 1 |
| Zhang, W | 1 |
| Quinn, B | 1 |
| Dasgupta, N | 1 |
| Blackwood, R | 1 |
| Setchell, KD | 1 |
| Fleming, S | 1 |
| Grabowski, GA | 1 |
| Marshall, J | 1 |
| Sun, Y | 1 |
| Wiesmann, T | 1 |
| Freitag, D | 1 |
| Dersch, W | 1 |
| Eschbach, D | 1 |
| Irqsusi, M | 1 |
| Steinfeldt, T | 1 |
| Wulf, H | 1 |
| Feldmann, C | 1 |
| Kasatkin, DS | 1 |
| Said, M | 1 |
| Becerra, R | 1 |
| Palomeque, J | 1 |
| Rinaldi, G | 1 |
| Kaetzel, MA | 1 |
| Diaz-Sylvester, PL | 1 |
| Copello, JA | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Botulinum Toxin A for the Treatment of Chemotherapy Induced Peripheral Neuropathy[NCT03571334] | Phase 2 | 40 participants (Anticipated) | Interventional | 2020-07-08 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
7 reviews available for dantrolene and Disease Models, Animal
| Article | Year |
|---|---|
Effects of dantrolene on ischemia-reperfusion injury in animal models: a review of outcomes in heart, brain, liver, and kidney.
Topics: Animals; Brain; Calcium; Cytoprotection; Dantrolene; Disease Models, Animal; Heart; Kidney; Liver; R | 2010 |
Current concepts. The malignant hyperthermia syndrome.
Topics: Animals; Dantrolene; Disease Models, Animal; Halothane; Humans; Malignant Hyperthermia; Muscles; Swi | 1983 |
Malignant hyperthermia: responses of skeletal muscles to general anesthetics.
Topics: Animals; Calcium; Dantrolene; Disease Models, Animal; Humans; Malignant Hyperthermia; Muscles; Resea | 1983 |
Malignant hyperthermia--pearls out of swine?
Topics: Animals; Body Temperature; Dantrolene; Disease Models, Animal; Halothane; Magnesium Sulfate; Maligna | 1980 |
An update on the malignant hyperthermia syndrome.
Topics: Anesthetics; Animals; Calcium; Calcium Channels; Child; Dantrolene; Disease Models, Animal; Disease | 1994 |
[Malignant hyperthermia].
Topics: Biopsy; Child, Preschool; Dantrolene; Disease Models, Animal; Humans; Male; Malignant Hyperthermia; | 1999 |
Porcine malignant hyperthermia.
Topics: Anesthesia, Inhalation; Animals; Body Temperature Regulation; Calcium; Cell Membrane; Dantrolene; Di | 1979 |
1 trial available for dantrolene and Disease Models, Animal
| Article | Year |
|---|---|
Dantrolene versus amiodarone for cardiopulmonary resuscitation: a randomized, double-blinded experimental study.
Topics: Amiodarone; Animals; Blood Gas Analysis; Brain; Cardiopulmonary Resuscitation; Dantrolene; Disease M | 2017 |
75 other studies available for dantrolene and Disease Models, Animal
| Article | Year |
|---|---|
Stabilization of RyR2 maintains right ventricular function, reduces the development of ventricular arrhythmias, and improves prognosis in pulmonary hypertension.
Topics: Animals; Arrhythmias, Cardiac; Dantrolene; Disease Models, Animal; Hypertension, Pulmonary; Male; Mo | 2022 |
Dantrolene reduces platelet-derived growth factor (PDGF)-induced vascular smooth muscle cell proliferation and neointimal formation following vascular injury in mice.
Topics: Animals; Cell Movement; Cell Proliferation; Cells, Cultured; Dantrolene; Disease Models, Animal; Mic | 2022 |
Protein mishandling and impaired lysosomal proteolysis generated through calcium dysregulation in Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Calcium; Calcium, Dietary; Dantrolene; Disease Models, Animal; Humans; L | 2022 |
Protein mishandling and impaired lysosomal proteolysis generated through calcium dysregulation in Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Calcium; Calcium, Dietary; Dantrolene; Disease Models, Animal; Humans; L | 2022 |
Protein mishandling and impaired lysosomal proteolysis generated through calcium dysregulation in Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Calcium; Calcium, Dietary; Dantrolene; Disease Models, Animal; Humans; L | 2022 |
Protein mishandling and impaired lysosomal proteolysis generated through calcium dysregulation in Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Calcium; Calcium, Dietary; Dantrolene; Disease Models, Animal; Humans; L | 2022 |
Protective effects of dantrolene and methylprednisolone against spinal cord injury-induced early oxidative damage in rabbit bladder: A comparative experimental study.
Topics: Animals; Antioxidants; Dantrolene; Disease Models, Animal; Lipid Peroxidation; Methylprednisolone; M | 2019 |
Chronic Dantrolene Treatment Does Not Affect Hypertension, but Attenuates Sympathetic Stimulation Enhanced Atrial Fibrillation Inducibility in SHR.
Topics: Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; Blood Pressure; Dantrolene; Disease Models, An | 2020 |
Intranasal Dantrolene as a Disease-Modifying Drug in Alzheimer 5XFAD Mice.
Topics: Administration, Intranasal; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Brain; Dantr | 2020 |
Investigation of the Possible Protective Effects of Ketamine and Dantrolene on the Hippocampal Apoptosis and Spatial Learning in Rats Exposed to Repeated Electroconvulsive Seizures as a Model of Status Epilepticus.
Topics: Animals; Apoptosis; Dantrolene; Disease Models, Animal; Electroshock; Hippocampus; Ketamine; Male; M | 2020 |
Design, synthesis, and biological activity of novel semicarbazones as potent Ryanodine receptor1 inhibitors of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Calcium Channel Blockers; Calcium Signaling; Dantrolene; Disease Models, | 2021 |
Ryanodine-receptor inhibition by dantrolene effectively suppresses ventricular arrhythmias in an ex vivo model of long-QT syndrome.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Calcium Channel Blockers; Dantrolene; Disease Mo | 2018 |
Failing Hearts Are More Vulnerable to Sympathetic, but Not Vagal Stimulation-Induced, Atrial Fibrillation-Ameliorated with Dantrolene Treatment.
Topics: Animals; Atrial Fibrillation; Dantrolene; Disease Models, Animal; Electric Stimulation Therapy; Hear | 2018 |
A novel target for the promotion of dermal wound healing: Ryanodine receptors.
Topics: Animals; Blood Flow Velocity; Calcium Channel Blockers; Calcium Signaling; Cell Line; Cell Prolifera | 2019 |
Dantrolene improves survival after ventricular fibrillation by mitigating impaired calcium handling in animal models.
Topics: Animals; Calcium; Cardiopulmonary Resuscitation; Dantrolene; Death, Sudden, Cardiac; Disease Models, | 2014 |
[Effect and mechanism of dantrolene on skeletal muscle of rats with severe scald injury].
Topics: Animals; Burns; Calcium; Calpain; Dantrolene; Disease Models, Animal; Male; Muscle, Skeletal; Rats; | 2014 |
Effects of methylprednisolone, dantrolene, and their combination on experimental spinal cord injury.
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Dantrolene; Disease Models, Animal; Drug Therapy, Comb | 2014 |
Increase of type 2 ryanodine receptors in mouse nucleus accumbens in the development and expression of morphine-induced place preference.
Topics: Animals; Behavior, Animal; Calcium Channel Blockers; Conditioning, Psychological; Dantrolene; Diseas | 2014 |
Effects of Dantrolene Treatment on Ventricular Electrophysiology and Arrhythmogenesis in Rats With Chronic β-Adrenergic Receptor Activation.
Topics: Action Potentials; Animals; Arrhythmias, Cardiac; Calcium; Cardiotonic Agents; Dantrolene; Disease M | 2015 |
Calcium dysregulation via L-type voltage-dependent calcium channels and ryanodine receptors underlies memory deficits and synaptic dysfunction during chronic neuroinflammation.
Topics: AIDS-Related Complex; Analysis of Variance; Animals; Calcium; Calcium Channel Blockers; Calcium Chan | 2015 |
CaMKII-dependent phosphorylation of RyR2 promotes targetable pathological RyR2 conformational shift.
Topics: Animals; Calcium; Calcium Signaling; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calmodulin; | 2016 |
Modulating ryanodine receptors with dantrolene attenuates neuronopathic phenotype in Gaucher disease mice.
Topics: Animals; Calcium Signaling; Dantrolene; Disease Models, Animal; Gaucher Disease; Humans; Mice; Mitoc | 2016 |
[Pathogenetic therapy of spasticity].
Topics: Adult; Aged; Animals; Cerebral Palsy; Child; Controlled Clinical Trials as Topic; Dantrolene; Diseas | 2008 |
Increased intracellular Ca2+ and SR Ca2+ load contribute to arrhythmias after acidosis in rat heart. Role of Ca2+/calmodulin-dependent protein kinase II.
Topics: Acidosis; Action Potentials; Animals; Arrhythmias, Cardiac; Benzylamines; Calcium; Calcium-Binding P | 2008 |
Can dantrolene protect spinal cord against ischemia/reperfusion injury? An experimental study.
Topics: Animals; Antioxidants; Aorta, Abdominal; Biomarkers; Constriction; Dantrolene; Disease Models, Anima | 2008 |
Deranged calcium signaling and neurodegeneration in spinocerebellar ataxia type 3.
Topics: Adult; Animals; Animals, Genetically Modified; Ataxin-3; Brain; Calcium Signaling; Cells, Cultured; | 2008 |
Dantrolene, a therapeutic agent for malignant hyperthermia, markedly improves the function of failing cardiomyocytes by stabilizing interdomain interactions within the ryanodine receptor.
Topics: Animals; Calcium; Dantrolene; Disease Models, Animal; Dogs; Heart Failure; Malignant Hyperthermia; M | 2009 |
Dantrolene can reduce secondary damage after spinal cord injury.
Topics: Animals; Antioxidants; Apoptosis; Cell Count; Dantrolene; Disease Models, Animal; Disease Progressio | 2009 |
Different antinociceptive effects of botulinum toxin type A in inflammatory and peripheral polyneuropathic rat models.
Topics: Analgesics; Animals; Botulinum Toxins, Type A; Carrageenan; Dantrolene; Disease Models, Animal; Edem | 2009 |
GIF-0173 protects against cerebral infarction through DP1 receptor activation.
Topics: Animals; Brain Infarction; Calcium; Cell Death; Cells, Cultured; Cerebral Cortex; Cerebrovascular Ci | 2009 |
Dissociation of calmodulin from cardiac ryanodine receptor causes aberrant Ca(2+) release in heart failure.
Topics: Animals; Calcium Signaling; Calmodulin; Cardiac Pacing, Artificial; Dantrolene; Disease Models, Anim | 2010 |
Dantrolene mitigates caerulein-induced pancreatitis in vivo in mice.
Topics: Amylases; Animals; Apoptosis; Calcium Channel Blockers; Calcium Signaling; Ceruletide; Cytoprotectio | 2010 |
Assessment of the effect of the use of laser light or dantrolene on facial muscle under occlusal wear: a Raman spectroscopic study in a rodent model.
Topics: Animals; Calcium; Dantrolene; Disease Models, Animal; Facial Muscles; Low-Level Light Therapy; Male; | 2010 |
Impaired hippocampal Ca2+ homeostasis and concomitant K+ channel dysfunction in a mouse model of Rett syndrome during anoxia.
Topics: Analysis of Variance; Animals; Benzophenones; Biophysical Phenomena; Boron Compounds; Calcium; Chary | 2010 |
Dantrolene, a therapeutic agent for malignant hyperthermia, inhibits catecholaminergic polymorphic ventricular tachycardia in a RyR2(R2474S/+) knock-in mouse model.
Topics: Adrenergic alpha-Agonists; Animals; Anti-Arrhythmia Agents; Calcium; Dantrolene; Disease Models, Ani | 2010 |
Ethanol enhances carbachol-induced protease activation and accelerates Ca2+ waves in isolated rat pancreatic acini.
Topics: Alcoholism; Animals; Calcium; Carbachol; Chymotrypsin; Dantrolene; Disease Models, Animal; Ethanol; | 2011 |
Comparison of the therapeutic effectiveness of a dantrolene sodium solution and a novel nanocrystalline suspension of dantrolene sodium in malignant hyperthermia normal and susceptible pigs.
Topics: Animals; Biomarkers; Chemistry, Pharmaceutical; Dantrolene; Disease Models, Animal; Halothane; Hemod | 2011 |
HTDP-2, a new synthetic compound, inhibits glutamate release through reduction of voltage-dependent Ca²⁺ influx in rat cerebral cortex nerve terminals.
Topics: 4-Aminopyridine; Amino Acid Transport System X-AG; Animals; Calcium; Calcium Channel Blockers; Calci | 2011 |
The ameliorating effect of dantrolene on the morphology of urinary bladder in spinal cord injured rats.
Topics: Animals; Cystitis; Dantrolene; Disease Models, Animal; Hemorrhage; Male; Neuroprotective Agents; Rat | 2011 |
Dantrolene is neuroprotective in Huntington's disease transgenic mouse model.
Topics: Animals; Apoptosis; Caffeine; Calcium; Calcium Signaling; Cells, Cultured; Central Nervous System St | 2011 |
Dantrolene prevents arrhythmogenic Ca2+ release in heart failure.
Topics: Animals; Arrhythmias, Cardiac; Calcium; Cells, Cultured; Dantrolene; Disease Models, Animal; Heart F | 2012 |
Involvement of ryanodine receptors in tetanic sciatic stimulation-induced long-term potentiation of spinal dorsal horn and persistent pain in rats.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2012 |
Dantrolene ameliorates cognitive decline and neuropathology in Alzheimer triple transgenic mice.
Topics: Alzheimer Disease; Animals; Blotting, Western; Cognition Disorders; Dantrolene; Disease Models, Anim | 2012 |
Dantrolene is neuroprotective in vitro, but does not affect survival in SOD1(G⁹³A) mice.
Topics: Amyotrophic Lateral Sclerosis; Animals; Calcium; Dantrolene; Disease Models, Animal; Humans; Immunoh | 2012 |
Ryanodine receptor blockade reduces amyloid-β load and memory impairments in Tg2576 mouse model of Alzheimer disease.
Topics: Alzheimer Disease; Aminophenols; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Prec | 2012 |
Antispasmodic effect of shakuyakukanzoto extract on experimental muscle cramps in vivo: role of the active constituents of Glycyrrhizae radix.
Topics: Animals; Animals, Outbred Strains; Chalcone; Chalcones; Coumarins; Dantrolene; Disease Models, Anima | 2013 |
Genetics. A genetic intervention stands a skip away from clinical tests.
Topics: Animals; Calcium Channel Blockers; Clinical Trials as Topic; Dantrolene; Disease Models, Animal; Dys | 2012 |
Dantrolene enhances antisense-mediated exon skipping in human and mouse models of Duchenne muscular dystrophy.
Topics: Animals; Cell Line; Dantrolene; Disease Models, Animal; Drug Synergism; Dystrophin; Exons; High-Thro | 2012 |
Dopamine D1 receptor signaling system regulates ryanodine receptor expression in ethanol physical dependence.
Topics: Alcoholism; Animals; Benzazepines; Blotting, Western; Brain; Central Nervous System Depressants; Dan | 2013 |
Stabilizing ER Ca2+ channel function as an early preventative strategy for Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Calcium; Calcium Signaling; Dantrolene; Disease M | 2012 |
Anti-inflammatory and antinociceptive properties of dantrolene sodium in rats and mice.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Dantrolene; | 2002 |
Incremental responses of compound muscle action potentials in normal rats produced by repeated electrical stimulation.
Topics: Action Potentials; Animals; Calcium Channel Blockers; Dantrolene; Disease Models, Animal; Electric S | 2003 |
Dantrolene use in 3,4-methylenedioxymethamphetamine (ecstasy)-mediated hyperthermia.
Topics: Animals; Body Temperature; Dantrolene; Disease Models, Animal; Hallucinogens; Malignant Hyperthermia | 2004 |
Prevention of acute adriamycin cardiotoxicity by dantrolene in rats.
Topics: Animals; Antioxidants; Aspartate Aminotransferases; Cardiomyopathies; Creatine Kinase; Dantrolene; D | 2004 |
Protective effects of dantrolene against myocardial injury induced by isoproterenol in rats: biochemical and histological findings.
Topics: Adrenergic beta-Agonists; Animals; Dantrolene; Disease Models, Animal; Heart; Isoproterenol; Male; M | 2005 |
The protective effect of dantrolene on ischemic neuronal cell death is associated with reduced expression of endoplasmic reticulum stress markers.
Topics: Activating Transcription Factor 4; Analysis of Variance; Animals; Blotting, Western; CCAAT-Enhancer- | 2005 |
Effect of dantrolene on lipid peroxidation, lutathione and glutathione-dependent enzyme activities in experimental otitis media with effusion in guinea pigs.
Topics: Animals; Dantrolene; Disease Models, Animal; Erythrocytes; Glutathione; Glutathione Peroxidase; Glut | 2005 |
Dantrolene, a calcium-induced calcium release inhibitor, prevents the acquisition of amygdaloid kindling in rats, a model of experimental epilepsy.
Topics: Animals; Calcium; Dantrolene; Disease Models, Animal; Epilepsy; Kindling, Neurologic; Male; Rats; Ra | 2006 |
The effects of dantrolene on hypoxic-ischemic injury in the neonatal rat brain.
Topics: Animals; Animals, Newborn; Apoptosis; Aspartic Acid; Brain; Carotid Artery, Common; Creatine; Dantro | 2008 |
Therapeutic approach to experimental autoimmune myasthenia gravis by dantrolene sodium.
Topics: Animals; Autoimmune Diseases; Calcium; Dantrolene; Disease Models, Animal; Female; Membrane Potentia | 1983 |
The chick as a model for malignant hyperpyrexia.
Topics: Animals; Calcium; Chickens; Dantrolene; Disease Models, Animal; Drug Evaluation, Preclinical; Malign | 1980 |
Modification of ryanodine toxicity by dantrolene and halothane in a model of malignant hyperthermia.
Topics: Alkaloids; Animals; Dantrolene; Diaphragm; Disease Models, Animal; Halothane; In Vitro Techniques; M | 1980 |
No dantrolene protection in a dog model of complete cerebral ischaemia.
Topics: Animals; Blood Gas Analysis; Brain Ischemia; Calcium; Dantrolene; Disease Models, Animal; Dogs; Elec | 1993 |
Increased intracellular Ca2+: a critical link in the pathophysiology of sepsis?
Topics: Animals; Aorta, Thoracic; Calcium; Chelating Agents; Dantrolene; Disease Models, Animal; Egtazic Aci | 1993 |
Dantrolene, an inhibitor of intracellular calcium release, fails to increase survival in a rat model of intra-abdominal sepsis.
Topics: Animals; Calcium; Dantrolene; Disease Models, Animal; Escherichia coli Infections; Lactates; Male; P | 1996 |
Effects of dantrolene on cooling times and cardiovascular parameters in an immature porcine model of heatstroke.
Topics: Animals; Body Temperature; Cardiovascular System; Dantrolene; Disease Models, Animal; Fluid Therapy; | 1997 |
Development of an animal model for neuroleptic malignant syndrome: heat-exposed rabbits with haloperidol and atropine administration exhibit increased muscle activity, hyperthermia, and high serum creatine phosphokinase level.
Topics: Animals; Antipsychotic Agents; Atropine; Body Temperature Regulation; Cholinergic Antagonists; Creat | 1996 |
Influence of isradipine, niguldipine and dantrolene on the anticonvulsive action of conventional antiepileptics in mice.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1997 |
Dantrolene and recovery from heat stroke.
Topics: Analysis of Variance; Animals; Body Temperature; Body Temperature Regulation; Dantrolene; Disease Mo | 1999 |
Effects of MK-801, dantrolene, and FK506 on convulsive seizures and brain nitric oxide production in seizure-susceptible EL mice.
Topics: Animals; Brain; Brain Chemistry; Calcineurin; Calcium; Dantrolene; Disease Models, Animal; Dizocilpi | 2001 |
Potent serotonin (5-HT)(2A) receptor antagonists completely prevent the development of hyperthermia in an animal model of the 5-HT syndrome.
Topics: 5-Hydroxytryptophan; Animals; Anterior Hypothalamic Nucleus; Antidepressive Agents; Body Temperature | 2001 |
Dantrolene ameliorates delayed cell death and concomitant DNA fragmentation in the rat hippocampal CA1 neurons subjected to mild ischemia.
Topics: Animals; Apoptosis; Brain Ischemia; Dantrolene; Disease Models, Animal; DNA Fragmentation; Hippocamp | 2001 |
Rationale for dantrolene vs. procainamide for treatment of malignant hyperthermia.
Topics: Animals; Dantrolene; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Halothane; Hy | 1979 |
Relief of myotonia by dantrolene in experimental myotonia.
Topics: Animals; Dantrolene; Disease Models, Animal; Hydantoins; Male; Muscle Contraction; Muscle Relaxation | 1978 |
A possible new approach to the treatment of neuroleptic malignant syndrome.
Topics: Animals; Dantrolene; Disease Models, Animal; Humans; Neuroleptic Malignant Syndrome | 1992 |
Is dantrolene safe to administer in sepsis? The effect of dantrolene after endotoxin administration in dogs and rats.
Topics: Analysis of Variance; Animals; Dantrolene; Disease Models, Animal; Dogs; Endotoxins; Escherichia col | 1991 |
Effects of dantrolene sodium in rodent models of cardiac arrhythmia.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Coronary Vessels; Dantrole | 1989 |
Dantrolene sodium for treatment of heatstroke victims: lack of efficacy in a canine model.
Topics: Animals; Creatine Kinase; Creatinine; Dantrolene; Disease Models, Animal; Dogs; Heat Exhaustion; Hem | 1986 |