dantrolene has been researched along with Diathesis in 38 studies
Dantrolene: Skeletal muscle relaxant that acts by interfering with excitation-contraction coupling in the muscle fiber. It is used in spasticity and other neuromuscular abnormalities. Although the mechanism of action is probably not central, dantrolene is usually grouped with the central muscle relaxants.
dantrolene : The hydrazone resulting from the formal condensation of 5-(4-nitrophenyl)furfural with 1-aminohydantoin. A ryanodine receptor antagonist used for the relief of chronic severe spasticity and malignant hyperthermia.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The halothane/caffeine contracture test was performed on the biopsied muscle." | 3.69 | Incidence of malignant hyperthermia reactions in 2,214 patients undergoing muscle biopsy. ( Britt, BA; Carr, AS; Cunliffe, M; Lerman, J; McLeod, ME, 1995) |
| " Hypotension was treated with ephedrine." | 3.69 | Anaesthesia for caesarean delivery of a malignant hyperthermia susceptible parturient. ( Lucy, SJ, 1994) |
| "The most common is malignant hyperthermia (MH), a dangerous hypermetabolic state after anaesthesia with suxamethonium and/or volatile halogenated anaesthetic agents." | 2.40 | Malignant hyperthermia. ( Denborough, M, 1998) |
| "Two of the persisting controversies concerning malignant hyperthermia (MH) are discussed: storing and dosage of dantrolene and preoperative tactics to be followed with patients who are MH-susceptible." | 2.38 | [An attempt to reconcile differences of opinion in the field of malignant hyperthermia]. ( Eberlein, HJ; Schulte-Sasse, U, 1991) |
| "Death from malignant hyperthermia (MH) still occurs in France." | 2.38 | [Management of a patient with malignant hyperthermia susceptibility during anesthesia and daily living]. ( Jacquot, C; Stieglitz, P, 1989) |
| " These results were likely due to the relatively high bioavailability of oral dantrolene and, possibly, to continued absorption of dantrolene in the postoperative period." | 2.37 | Plasma levels of dantrolene following oral administration in malignant hyperthermia-susceptible patients. ( Allen, GC; Cattran, CB; Lalande, M; Peterson, RG, 1988) |
| "A case of susceptibility to malignant hyperthermia, diagnosed by muscle biopsy during the first trimester of pregnancy, is presented." | 1.28 | Diagnosis and management of susceptibility to malignant hyperthermia in pregnancy. ( Botti, JJ; Ingardia, CJ; Sorosky, JI, 1989) |
| "A 55-year-old, malignant hyperthermia-susceptible patient underwent myocardial revascularization without incident." | 1.28 | Rewarming following hypothermic cardiopulmonary bypass in the malignant hyperthermia-susceptible patient: implications for diagnosis and perioperative management. ( Allen, GC; Cattran, CB, 1989) |
| " Thereafter, the concentration of dantrolene decreased slowly with an elimination half-life (mean +/- SD) of 10." | 1.28 | Pharmacokinetics of intravenous dantrolene in children. ( Lerman, J; McLeod, ME; Strong, HA, 1989) |
| "We describe a young man who experienced malignant hyperpyrexia, probably triggered by suxamethonium and/or enflurane during his second operation for an epigastric hernia." | 1.27 | Spinal block, after dantrolene pretreatment, for resection of a thigh muscle herniation in a young malignant hyperthermia susceptible man. ( Björkenheim, JM; Huopaniemi, T; Oikkonen, M; Paetau, A; Rosenberg, PH, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 17 (44.74) | 18.7374 |
| 1990's | 19 (50.00) | 18.2507 |
| 2000's | 1 (2.63) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (2.63) | 2.80 |
| Authors | Studies |
|---|---|
| Aldrich, K | 1 |
| Velez-Irizarry, D | 1 |
| Fenger, C | 1 |
| Schott, M | 1 |
| Valberg, SJ | 1 |
| Blanck, TJ | 1 |
| Gruener, RP | 1 |
| Willner, J | 1 |
| Schvaneveldt, JA | 1 |
| Stankiewicz, JA | 1 |
| Tonner, PH | 1 |
| Scholz, J | 1 |
| Richter, A | 1 |
| Löscher, W | 1 |
| Steinfath, M | 1 |
| Wappler, F | 1 |
| Wlaz, P | 1 |
| Hadji, B | 1 |
| Roewer, N | 1 |
| Schulte am Esch, J | 1 |
| Rosenberg, H | 1 |
| Fletcher, JE | 1 |
| Bello, N | 1 |
| Adnet, P | 1 |
| Saulnier, F | 1 |
| Lestavel, P | 1 |
| Adnet-Bonte, C | 1 |
| Reyford, H | 1 |
| Etchrivi, T | 1 |
| Tavernier, B | 1 |
| Krivosic-Horber, R | 1 |
| Carr, AS | 1 |
| Lerman, J | 2 |
| Cunliffe, M | 1 |
| McLeod, ME | 2 |
| Britt, BA | 1 |
| Lucy, SJ | 1 |
| Ellis, FR | 1 |
| Hassall, PJ | 1 |
| Hopkins, PM | 1 |
| Goto, S | 1 |
| Ogata, K | 1 |
| Fujie, T | 1 |
| Fujigaki, T | 1 |
| Nakamura, H | 1 |
| Yukinari, T | 1 |
| Shibata, O | 1 |
| Ben Abraham, R | 1 |
| Cahana, A | 1 |
| Krivosic-Horber, RM | 1 |
| Perel, A | 1 |
| Pollock, AN | 1 |
| McKenzie, AJ | 1 |
| Hodges, M | 2 |
| Snoeck, MM | 1 |
| Plötz, FB | 1 |
| Waalkens, HJ | 1 |
| Verkade, HJ | 1 |
| Michalek-Sauberer, A | 1 |
| Gilly, H | 1 |
| Denborough, M | 1 |
| Short, JA | 1 |
| Cooper, CM | 1 |
| López, JR | 4 |
| Cordovez, G | 1 |
| Linares, N | 1 |
| Allen, PD | 3 |
| Harrison, GG | 1 |
| Relton, JE | 1 |
| Pollock, N | 1 |
| Sendall, J | 1 |
| Gerardi, A | 1 |
| Lopez, MJ | 1 |
| Schulte-Sasse, U | 1 |
| Eberlein, HJ | 1 |
| Quinlan, JG | 1 |
| Wedel, DJ | 1 |
| Iaizzo, PA | 1 |
| Hackl, W | 1 |
| Mauritz, W | 1 |
| Winkler, M | 1 |
| Sporn, P | 1 |
| Steinbereithner, K | 1 |
| Sanchez, V | 1 |
| Lopez, I | 1 |
| Ryan, JF | 2 |
| Mendoza, M | 1 |
| Sreter, FA | 1 |
| Foster, PS | 1 |
| Hopkinson, KC | 1 |
| Denborough, MA | 1 |
| Ording, H | 1 |
| Jacquot, C | 1 |
| Stieglitz, P | 1 |
| Sorosky, JI | 1 |
| Ingardia, CJ | 1 |
| Botti, JJ | 1 |
| Allen, GC | 2 |
| Cattran, CB | 2 |
| Strong, HA | 1 |
| Peterson, RG | 1 |
| Lalande, M | 1 |
| Eichhorn, JH | 1 |
| Allen, P | 1 |
| Alamo, L | 1 |
| Jones, DE | 1 |
| Sreter, F | 1 |
| Oikkonen, M | 1 |
| Rosenberg, PH | 1 |
| Björkenheim, JM | 1 |
| Paetau, A | 1 |
| Huopaniemi, T | 1 |
| Mora, CT | 1 |
| Eisenkraft, JB | 1 |
| Papatestas, AE | 1 |
| Souliere, CR | 1 |
| Weintraub, SJ | 1 |
| Kirchner, JC | 1 |
10 reviews available for dantrolene and Diathesis
| Article | Year |
|---|---|
Malignant hyperthermia.
Topics: Animals; Caffeine; Calcium; Cold Temperature; Creatine Kinase; Dantrolene; Disease Susceptibility; H | 1983 |
Malignant hyperthermia.
Topics: Anesthesia, General; Anesthesia, Local; Dantrolene; Disease Susceptibility; Female; Humans; Male; Ma | 1984 |
An update on the malignant hyperthermia syndrome.
Topics: Anesthetics; Animals; Calcium; Calcium Channels; Child; Dantrolene; Disease Models, Animal; Disease | 1994 |
Malignant hyperthermia susceptibility: anaesthetic implications and risk stratification.
Topics: Adolescent; Anesthesia; Anesthesia, Obstetrical; Cesarean Section; Child; Child, Preschool; Contrain | 1997 |
Malignant hyperthermia.
Topics: Adult; Aged; Anesthetics; Animals; Child; Creatine Kinase; Dantrolene; Disease Susceptibility; Exerc | 1998 |
Porcine malignant hyperthermia.
Topics: Anesthesia, Inhalation; Animals; Body Temperature Regulation; Calcium; Cell Membrane; Dantrolene; Di | 1979 |
[An attempt to reconcile differences of opinion in the field of malignant hyperthermia].
Topics: Dantrolene; Disease Susceptibility; Humans; Malignant Hyperthermia; Preoperative Care | 1991 |
Pathophysiology of malignant hyperthermia.
Topics: Animals; Calcium; Creatine Kinase; Dantrolene; Disease Susceptibility; Halothane; Humans; Lymphocyte | 1989 |
[Management of a patient with malignant hyperthermia susceptibility during anesthesia and daily living].
Topics: Activities of Daily Living; Anesthesia; Anesthesia Recovery Period; Anesthetics; Dantrolene; Disease | 1989 |
Plasma levels of dantrolene following oral administration in malignant hyperthermia-susceptible patients.
Topics: Administration, Oral; Adolescent; Adult; Dantrolene; Disease Susceptibility; Female; Humans; Male; M | 1988 |
28 other studies available for dantrolene and Diathesis
| Article | Year |
|---|---|
Pathways of calcium regulation, electron transport, and mitochondrial protein translation are molecular signatures of susceptibility to recurrent exertional rhabdomyolysis in Thoroughbred racehorses.
Topics: Animals; Calcium; Dantrolene; Disease Susceptibility; Electron Transport; Female; Genetic Predisposi | 2021 |
Malignant hyperpyrexia: an update for the otolaryngologist.
Topics: Adolescent; Adult; Aged; Animals; Child; Child, Preschool; Dantrolene; Disease Susceptibility; Diure | 1981 |
Alterations of inositol polyphosphates in skeletal muscle during porcine malignant hyperthermia.
Topics: Anesthetics, Inhalation; Animals; Chromatography, High Pressure Liquid; Dantrolene; Disease Suscepti | 1995 |
[Lack of sensitivity to per-anesthetic malignant hyperthermia in 32 patients who developed neuroleptic malignant syndrome].
Topics: Adolescent; Adult; Aged; Anesthesia, General; Caffeine; Contracture; Creatine Kinase; Dantrolene; Di | 1994 |
Incidence of malignant hyperthermia reactions in 2,214 patients undergoing muscle biopsy.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anesthesia Recovery Period; Anesthesia, Conduction; Anes | 1995 |
Anaesthesia for caesarean delivery of a malignant hyperthermia susceptible parturient.
Topics: Adult; Anesthesia, Inhalation; Anesthesia, Obstetrical; Anesthesia, Spinal; Bupivacaine; Cesarean Se | 1994 |
Malignant hyperthermia.
Topics: Anesthetics; Carbon Dioxide; Dantrolene; Disease Susceptibility; Humans; Malignant Hyperthermia; Ris | 1993 |
[Caesarean section in a patient with past history of fulminant malignant hyperthermia].
Topics: Adult; Anesthesia, Obstetrical; Anesthesia, Spinal; Cesarean Section; Dantrolene; Disease Susceptibi | 1993 |
Propofol and malignant hyperthermia susceptibility.
Topics: Acidosis; Adolescent; Adult; Aged; Anesthetics, Intravenous; Arrhythmias, Cardiac; Cause of Death; C | 1997 |
Fatal outcome after propofol sedation in children.
Topics: Anesthetics, Intravenous; Cause of Death; Child; Dantrolene; Disease Susceptibility; Humans; Hypnoti | 1997 |
Prophylactic use of dantrolene in a patient with central core disease.
Topics: Cardiomyopathy, Dilated; Chemoprevention; Dantrolene; Disease Susceptibility; Heart Transplantation; | 1998 |
Suspected recurrence of malignant hyperthermia after post-extubation shivering in the intensive care unit, 18 h after tonsillectomy.
Topics: Adult; Dantrolene; Disease Susceptibility; Humans; Male; Malignant Hyperthermia; Muscle Relaxants, C | 1999 |
Cyclic ADP-ribose induces a larger than normal calcium release in malignant hyperthermia-susceptible skeletal muscle fibers.
Topics: Adenosine Diphosphate Ribose; Animals; Calcium; Calcium Channel Blockers; Cyclic ADP-Ribose; Dantrol | 2000 |
Anesthesia for elective surgery in patients susceptible to malignant hyperthermia.
Topics: Anesthesia, General; Anesthesia, Inhalation; Anesthesia, Local; Dantrolene; Disease Susceptibility; | 1979 |
Prolonged malignant hyperthermia in the absence of triggering agents.
Topics: Adolescent; Dantrolene; Disease Susceptibility; Humans; Intraoperative Complications; Male; Malignan | 1992 |
Effects of dantrolene on myoplasmic free [Ca2+] measured in vivo in patients susceptible to malignant hyperthermia.
Topics: Calcium; Dantrolene; Disease Susceptibility; Dose-Response Relationship, Drug; Electric Stimulation; | 1992 |
Multiple-pulse stimulation and dantrolene in malignant hyperthermia.
Topics: Adult; Dantrolene; Disease Susceptibility; Electric Stimulation; Electromyography; Female; Humans; L | 1990 |
Anaesthesia in malignant hyperthermia-susceptible patients without dantrolene prophylaxis: a report of 30 cases.
Topics: Adolescent; Adult; Aged; Anesthesia, General; Child; Dantrolene; Disease Susceptibility; Female; Hum | 1990 |
The effects of extracellular magnesium on myoplasmic [Ca2+] in malignant hyperthermia susceptible swine.
Topics: Animals; Calcium; Dantrolene; Disease Susceptibility; Extracellular Space; Halothane; Magnesium Sulf | 1990 |
Effect of diltiazem, verapamil and dantrolene on the contractility of isolated malignant hyperpyrexia-susceptible human skeletal muscle.
Topics: Caffeine; Dantrolene; Diltiazem; Disease Susceptibility; Halothane; Humans; In Vitro Techniques; Mal | 1989 |
Diagnosis and management of susceptibility to malignant hyperthermia in pregnancy.
Topics: Adult; Anesthesia, Obstetrical; Biopsy; Dantrolene; Delivery, Obstetric; Disease Susceptibility; Fem | 1989 |
Rewarming following hypothermic cardiopulmonary bypass in the malignant hyperthermia-susceptible patient: implications for diagnosis and perioperative management.
Topics: Cardiopulmonary Bypass; Dantrolene; Disease Susceptibility; Hot Temperature; Humans; Hypothermia, In | 1989 |
Pharmacokinetics of intravenous dantrolene in children.
Topics: Child; Child, Preschool; Chromatography, High Pressure Liquid; Dantrolene; Disease Susceptibility; H | 1989 |
Malignant hyperthermia revisited.
Topics: Biopsy; Dantrolene; Disease Susceptibility; Humans; Malignant Hyperthermia; Muscular Diseases; Surge | 1988 |
Dantrolene prevents the malignant hyperthermic syndrome by reducing free intracellular calcium concentration in skeletal muscle of susceptible swine.
Topics: Anesthetics; Animals; Calcium; Dantrolene; Disease Susceptibility; Female; Male; Malignant Hyperther | 1987 |
Spinal block, after dantrolene pretreatment, for resection of a thigh muscle herniation in a young malignant hyperthermia susceptible man.
Topics: Adolescent; Adult; Anesthesia, Spinal; Child; Dantrolene; Disease Susceptibility; Herniorrhaphy; Hum | 1987 |
Intravenous dantrolene in a patient with myasthenia gravis.
Topics: Adolescent; Anesthesia, General; Dantrolene; Disease Susceptibility; Drug Evaluation; Electromyograp | 1986 |
Markedly delayed postoperative malignant hyperthermia.
Topics: Adenoidectomy; Anesthesia, Inhalation; Child; Creatine Kinase; Dantrolene; Disease Susceptibility; H | 1986 |