dantrolene has been researched along with Cerebrovascular Disorders in 6 studies
Dantrolene: Skeletal muscle relaxant that acts by interfering with excitation-contraction coupling in the muscle fiber. It is used in spasticity and other neuromuscular abnormalities. Although the mechanism of action is probably not central, dantrolene is usually grouped with the central muscle relaxants.
dantrolene : The hydrazone resulting from the formal condensation of 5-(4-nitrophenyl)furfural with 1-aminohydantoin. A ryanodine receptor antagonist used for the relief of chronic severe spasticity and malignant hyperthermia.
Cerebrovascular Disorders: A spectrum of pathological conditions of impaired blood flow in the brain. They can involve vessels (ARTERIES or VEINS) in the CEREBRUM, the CEREBELLUM, and the BRAIN STEM. Major categories include INTRACRANIAL ARTERIOVENOUS MALFORMATIONS; BRAIN ISCHEMIA; CEREBRAL HEMORRHAGE; and others.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Forty patients, whose ages varied from 4 to 65 years, presenting skeletal muscle spascitiy as sequel of cerebral palsy, spinovertebral trauma and cerebral vascular diseases were treated with Dantrium (dantrolene sodium), a drug muscle relaxing." | 3.65 | [Sodium dantrolene (dantrium) in the treatment of neurogenic muscular spasm]. ( Alvarenga, H; Araújo Leitão, RE; Couto, B; Figuereido, HB; Gomes Marleide, M; Melo Reis, CH, 1976) |
| " Dantrium produced no alteration in clinical tone, functional outcome, or biochemical tests at the dosage (200 mg per day) used in this study." | 2.67 | Objective assessment of spasticity, strength, and function with early exhibition of dantrolene sodium after cerebrovascular accident: a randomized double-blind study. ( Cole, AM; Katrak, PH; McCauley, JC; Poulos, CJ, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (83.33) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ketel, WB | 1 |
| Kolb, ME | 1 |
| Couto, B | 1 |
| Figuereido, HB | 1 |
| Araújo Leitão, RE | 1 |
| Alvarenga, H | 1 |
| Gomes Marleide, M | 1 |
| Melo Reis, CH | 1 |
| Katrak, PH | 1 |
| Cole, AM | 1 |
| Poulos, CJ | 1 |
| McCauley, JC | 1 |
| Monster, AW | 2 |
| Glass, A | 1 |
| Hannah, A | 1 |
| Herman, R | 1 |
| Meeks, S | 1 |
| McHenry, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| To Estimate the Efficacy of Botulinum Toxin A Injection Combing With Exoskeleton Robotic Assisted Gait Training in Stroke Patients With Spastic Stiff Knee Gait: Motor Function Performance and Neurophysiological Evaluation[NCT06070987] | 36 participants (Anticipated) | Interventional | 2023-08-01 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 trials available for dantrolene and Cerebrovascular Disorders
| Article | Year |
|---|---|
Long-term treatment with dantrolene sodium of stroke patients with spasticity limiting the return of function.
Topics: Aged; Cerebrovascular Disorders; Dantrolene; Dose-Response Relationship, Drug; Double-Blind Method; | 1984 |
Objective assessment of spasticity, strength, and function with early exhibition of dantrolene sodium after cerebrovascular accident: a randomized double-blind study.
Topics: Aged; Aged, 80 and over; Cerebrovascular Disorders; Dantrolene; Double-Blind Method; Female; Humans; | 1992 |
Spasticity and the effect of dantrolene sodium.
Topics: Adult; Ankle Joint; Cerebrovascular Disorders; Clinical Trials as Topic; Dantrolene; Dose-Response R | 1974 |
A comparison of dantrolene sodium and diazepam in the treatment of spasticity.
Topics: Adolescent; Adult; Aged; Cerebrovascular Disorders; Clinical Trials as Topic; Dantrolene; Diazepam; | 1974 |
Cooperative study for assessing the effects of a pharmacological agent on spasticity.
Topics: Adult; Aged; Analog-Digital Conversion; Cerebrovascular Disorders; Computers, Analog; Dantrolene; El | 1973 |
1 other study available for dantrolene and Cerebrovascular Disorders
| Article | Year |
|---|---|
[Sodium dantrolene (dantrium) in the treatment of neurogenic muscular spasm].
Topics: Adolescent; Adult; Aged; Cerebral Palsy; Cerebrovascular Disorders; Child; Child, Preschool; Dantrol | 1976 |