dantrolene has been researched along with Cardiomyopathies in 4 studies
Dantrolene: Skeletal muscle relaxant that acts by interfering with excitation-contraction coupling in the muscle fiber. It is used in spasticity and other neuromuscular abnormalities. Although the mechanism of action is probably not central, dantrolene is usually grouped with the central muscle relaxants.
dantrolene : The hydrazone resulting from the formal condensation of 5-(4-nitrophenyl)furfural with 1-aminohydantoin. A ryanodine receptor antagonist used for the relief of chronic severe spasticity and malignant hyperthermia.
Cardiomyopathies: A group of diseases in which the dominant feature is the involvement of the CARDIAC MUSCLE itself. Cardiomyopathies are classified according to their predominant pathophysiological features (DILATED CARDIOMYOPATHY; HYPERTROPHIC CARDIOMYOPATHY; RESTRICTIVE CARDIOMYOPATHY) or their etiological/pathological factors (CARDIOMYOPATHY, ALCOHOLIC; ENDOCARDIAL FIBROELASTOSIS).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Dantrolene, at 5 mg/kg, was useful to obtain significant protective effects, while the protector effect of higher dantrolene dosing level (10 mg/kg) was weak or absent." | 1.32 | Prevention of acute adriamycin cardiotoxicity by dantrolene in rats. ( Bakan, E; Buyukavci, M; Büyükokuroğlu, ME; Taysi, S, 2004) |
| "Septic shock is a complex pathophysiologic state characterized by circulatory insufficiency, multiple system organ dysfunction, and frequent mortality." | 1.31 | Increased cardiomyocyte intracellular calcium during endotoxin-induced cardiac dysfunction in guinea pigs. ( Arteaga, G; Becker, L; Bryant, D; Giroir, BP; Horton, J; Kliewer, A; Maass, D; Thompson, M; White, DJ, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (75.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Campos, EC | 1 |
| O'Connell, JL | 1 |
| Malvestio, LM | 1 |
| Romano, MM | 1 |
| Ramos, SG | 1 |
| Celes, MR | 1 |
| Prado, CM | 1 |
| Simões, MV | 1 |
| Rossi, MA | 1 |
| Büyükokuroğlu, ME | 1 |
| Taysi, S | 1 |
| Buyukavci, M | 1 |
| Bakan, E | 1 |
| Hall, SR | 1 |
| Wang, L | 1 |
| Milne, B | 1 |
| Hong, M | 1 |
| Thompson, M | 1 |
| Kliewer, A | 1 |
| Maass, D | 1 |
| Becker, L | 1 |
| White, DJ | 1 |
| Bryant, D | 1 |
| Arteaga, G | 1 |
| Horton, J | 1 |
| Giroir, BP | 1 |
4 other studies available for dantrolene and Cardiomyopathies
| Article | Year |
|---|---|
Calpain-mediated dystrophin disruption may be a potential structural culprit behind chronic doxorubicin-induced cardiomyopathy.
Topics: Actins; Animals; Body Weight; Calpain; Cardiomyopathies; Cell Membrane Permeability; Dantrolene; Dox | 2011 |
Prevention of acute adriamycin cardiotoxicity by dantrolene in rats.
Topics: Animals; Antioxidants; Aspartate Aminotransferases; Cardiomyopathies; Creatine Kinase; Dantrolene; D | 2004 |
Mannitol but not dantrolene prevents myocardial dysfunction following intra-cranial hypertension in rats.
Topics: Animals; Blood Pressure; Calcium; Cardiomyopathies; Catecholamines; Dantrolene; Diuretics, Osmotic; | 2005 |
Increased cardiomyocyte intracellular calcium during endotoxin-induced cardiac dysfunction in guinea pigs.
Topics: Animals; Calcium; Cardiomyopathies; Cells, Cultured; Cytoplasm; Dantrolene; Escherichia coli; Fura-2 | 2000 |