dantrolene has been researched along with Cardiomegaly in 3 studies
Dantrolene: Skeletal muscle relaxant that acts by interfering with excitation-contraction coupling in the muscle fiber. It is used in spasticity and other neuromuscular abnormalities. Although the mechanism of action is probably not central, dantrolene is usually grouped with the central muscle relaxants.
dantrolene : The hydrazone resulting from the formal condensation of 5-(4-nitrophenyl)furfural with 1-aminohydantoin. A ryanodine receptor antagonist used for the relief of chronic severe spasticity and malignant hyperthermia.
Cardiomegaly: Enlargement of the HEART, usually indicated by a cardiothoracic ratio above 0.50. Heart enlargement may involve the right, the left, or both HEART VENTRICLES or HEART ATRIA. Cardiomegaly is a nonspecific symptom seen in patients with chronic systolic heart failure (HEART FAILURE) or several forms of CARDIOMYOPATHIES.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Hypertrophic cardiomyopathy is a major cause of mortality worldwide." | 1.72 | Cardioprotective Effect of Polymyxin-B and Dantrolene Combination on Isoproterenol-Induced Hypertrophic Cardiomyopathy in Rats, via Attenuation of Calmodulin-Dependent Protein Kinase II. ( Bhatt, LK; Shaikh, F, 2022) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 1 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Shaikh, F | 1 |
| Bhatt, LK | 1 |
| Oda, T | 1 |
| Yamamoto, T | 1 |
| Kato, T | 1 |
| Uchinoumi, H | 1 |
| Fukui, G | 1 |
| Hamada, Y | 1 |
| Nanno, T | 1 |
| Ishiguchi, H | 1 |
| Nakamura, Y | 1 |
| Okamoto, Y | 1 |
| Kono, M | 1 |
| Okuda, S | 1 |
| Kobayashi, S | 1 |
| Bers, DM | 1 |
| Yano, M | 1 |
| Zhang, Q | 1 |
| Goel, N | 1 |
| Rodriguez, R | 1 |
| Scholz, PM | 1 |
| Weiss, HR | 1 |
3 other studies available for dantrolene and Cardiomegaly
| Article | Year |
|---|---|
Cardioprotective Effect of Polymyxin-B and Dantrolene Combination on Isoproterenol-Induced Hypertrophic Cardiomyopathy in Rats, via Attenuation of Calmodulin-Dependent Protein Kinase II.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cardiomegaly; Cardiomyopathy, Hypertrop | 2022 |
Nuclear translocation of calmodulin in pathological cardiac hypertrophy originates from ryanodine receptor bound calmodulin.
Topics: Angiotensin II; Animals; Biological Transport; Calmodulin; Cardiomegaly; Cell Nucleus; Cells, Cultur | 2018 |
Importance of ryanodine receptors in effects of cyclic GMP is reduced in thyroxine-induced cardiac hypertrophy.
Topics: Animals; Calcium; Calcium Channel Blockers; Cardiomegaly; Cyclic GMP; Dantrolene; Heart Ventricles; | 2006 |