Page last updated: 2024-10-25

dantrolene and Brain Injuries

dantrolene has been researched along with Brain Injuries in 6 studies

Dantrolene: Skeletal muscle relaxant that acts by interfering with excitation-contraction coupling in the muscle fiber. It is used in spasticity and other neuromuscular abnormalities. Although the mechanism of action is probably not central, dantrolene is usually grouped with the central muscle relaxants.
dantrolene : The hydrazone resulting from the formal condensation of 5-(4-nitrophenyl)furfural with 1-aminohydantoin. A ryanodine receptor antagonist used for the relief of chronic severe spasticity and malignant hyperthermia.

Brain Injuries: Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits.

Research Excerpts

ExcerptRelevanceReference
"Malignant hyperthermia is an extremely dangerous condition that can occur with exposure to volatile inhalant anesthetics and depolarizing muscle relaxants, and that requires immediate intervention."1.91Pediatric fulminant malignant hyperthermia with severe electroencephalographic abnormality and brain damage: a case report. ( Ikeda, A; Kajihama, A; Minami, S; Nagafuchi, H; Shimizu, H; Yamada, K, 2023)
"Ever since, the concept of catatonia has been the focus of debate, a major point of discussion being its nosological status."1.34Catatonia and neuroleptic malignant syndrome: two sides of a coin? ( Santens, P; Vancaester, E, 2007)
"1S,3R-ACPD-induced seizures were antagonized by systemic administration of dantrolene, an inhibitor of intracellular calcium mobilization, but not by the ionotropic glutamate antagonists MK-801 or GYKI-52466."1.29Seizures and brain injury in neonatal rats induced by 1S,3R-ACPD, a metabotropic glutamate receptor agonist. ( Fix, AS; McDonald, JW; Schoepp, DD; Tizzano, JP, 1993)

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (16.67)18.2507
2000's3 (50.00)29.6817
2010's0 (0.00)24.3611
2020's2 (33.33)2.80

Authors

AuthorsStudies
Ovcjak, A1
Xiao, A1
Kim, JS1
Xu, B1
Szeto, V1
Turlova, E1
Abussaud, A1
Chen, NH1
Miller, SP1
Sun, HS1
Feng, ZP1
Minami, S1
Ikeda, A1
Yamada, K1
Kajihama, A1
Shimizu, H1
Nagafuchi, H1
Whyte, J1
Katz, D1
Long, D1
DiPasquale, MC1
Polansky, M1
Kalmar, K1
Giacino, J1
Childs, N1
Mercer, W1
Novak, P1
Maurer, P1
Eifert, B1
Vancaester, E1
Santens, P1
McDonald, JW1
Fix, AS1
Tizzano, JP1
Schoepp, DD1
Elovic, E1

Reviews

1 review available for dantrolene and Brain Injuries

ArticleYear
Principles of pharmaceutical management of spastic hypertonia.
    Physical medicine and rehabilitation clinics of North America, 2001, Volume: 12, Issue:4

    Topics: Anti-Dyskinesia Agents; Baclofen; Benzodiazepines; Botulinum Toxins; Brain Injuries; Clonidine; Dant

2001

Other Studies

5 other studies available for dantrolene and Brain Injuries

ArticleYear
Ryanodine receptor inhibitor dantrolene reduces hypoxic-ischemic brain injury in neonatal mice.
    Experimental neurology, 2022, Volume: 351

    Topics: Animals; Animals, Newborn; Brain Injuries; Calcium; Calcium Channel Blockers; Dantrolene; Homeostasi

2022
Pediatric fulminant malignant hyperthermia with severe electroencephalographic abnormality and brain damage: a case report.
    Journal of medical case reports, 2023, Apr-16, Volume: 17, Issue:1

    Topics: Brain; Brain Injuries; Child; Dantrolene; Electroencephalography; Humans; Infant; Male; Malignant Hy

2023
Predictors of outcome in prolonged posttraumatic disorders of consciousness and assessment of medication effects: A multicenter study.
    Archives of physical medicine and rehabilitation, 2005, Volume: 86, Issue:3

    Topics: Adult; Aged; Amantadine; Brain Injuries; Dantrolene; Data Collection; Disability Evaluation; Dopamin

2005
Catatonia and neuroleptic malignant syndrome: two sides of a coin?
    Acta neurologica Belgica, 2007, Volume: 107, Issue:2

    Topics: Adult; Aged; Alcoholism; Anticonvulsants; Antipsychotic Agents; Bipolar Disorder; Brain Injuries; Br

2007
Seizures and brain injury in neonatal rats induced by 1S,3R-ACPD, a metabotropic glutamate receptor agonist.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1993, Volume: 13, Issue:10

    Topics: Animals; Animals, Newborn; Anti-Anxiety Agents; Benzodiazepines; Brain Injuries; Cell Nucleus; Corpu

1993