dantrolene has been researched along with Brain Injuries in 6 studies
Dantrolene: Skeletal muscle relaxant that acts by interfering with excitation-contraction coupling in the muscle fiber. It is used in spasticity and other neuromuscular abnormalities. Although the mechanism of action is probably not central, dantrolene is usually grouped with the central muscle relaxants.
dantrolene : The hydrazone resulting from the formal condensation of 5-(4-nitrophenyl)furfural with 1-aminohydantoin. A ryanodine receptor antagonist used for the relief of chronic severe spasticity and malignant hyperthermia.
Brain Injuries: Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits.
Excerpt | Relevance | Reference |
---|---|---|
"Malignant hyperthermia is an extremely dangerous condition that can occur with exposure to volatile inhalant anesthetics and depolarizing muscle relaxants, and that requires immediate intervention." | 1.91 | Pediatric fulminant malignant hyperthermia with severe electroencephalographic abnormality and brain damage: a case report. ( Ikeda, A; Kajihama, A; Minami, S; Nagafuchi, H; Shimizu, H; Yamada, K, 2023) |
"Ever since, the concept of catatonia has been the focus of debate, a major point of discussion being its nosological status." | 1.34 | Catatonia and neuroleptic malignant syndrome: two sides of a coin? ( Santens, P; Vancaester, E, 2007) |
"1S,3R-ACPD-induced seizures were antagonized by systemic administration of dantrolene, an inhibitor of intracellular calcium mobilization, but not by the ionotropic glutamate antagonists MK-801 or GYKI-52466." | 1.29 | Seizures and brain injury in neonatal rats induced by 1S,3R-ACPD, a metabotropic glutamate receptor agonist. ( Fix, AS; McDonald, JW; Schoepp, DD; Tizzano, JP, 1993) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 1 (16.67) | 18.2507 |
2000's | 3 (50.00) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 2 (33.33) | 2.80 |
Authors | Studies |
---|---|
Ovcjak, A | 1 |
Xiao, A | 1 |
Kim, JS | 1 |
Xu, B | 1 |
Szeto, V | 1 |
Turlova, E | 1 |
Abussaud, A | 1 |
Chen, NH | 1 |
Miller, SP | 1 |
Sun, HS | 1 |
Feng, ZP | 1 |
Minami, S | 1 |
Ikeda, A | 1 |
Yamada, K | 1 |
Kajihama, A | 1 |
Shimizu, H | 1 |
Nagafuchi, H | 1 |
Whyte, J | 1 |
Katz, D | 1 |
Long, D | 1 |
DiPasquale, MC | 1 |
Polansky, M | 1 |
Kalmar, K | 1 |
Giacino, J | 1 |
Childs, N | 1 |
Mercer, W | 1 |
Novak, P | 1 |
Maurer, P | 1 |
Eifert, B | 1 |
Vancaester, E | 1 |
Santens, P | 1 |
McDonald, JW | 1 |
Fix, AS | 1 |
Tizzano, JP | 1 |
Schoepp, DD | 1 |
Elovic, E | 1 |
1 review available for dantrolene and Brain Injuries
Article | Year |
---|---|
Principles of pharmaceutical management of spastic hypertonia.
Topics: Anti-Dyskinesia Agents; Baclofen; Benzodiazepines; Botulinum Toxins; Brain Injuries; Clonidine; Dant | 2001 |
5 other studies available for dantrolene and Brain Injuries
Article | Year |
---|---|
Ryanodine receptor inhibitor dantrolene reduces hypoxic-ischemic brain injury in neonatal mice.
Topics: Animals; Animals, Newborn; Brain Injuries; Calcium; Calcium Channel Blockers; Dantrolene; Homeostasi | 2022 |
Pediatric fulminant malignant hyperthermia with severe electroencephalographic abnormality and brain damage: a case report.
Topics: Brain; Brain Injuries; Child; Dantrolene; Electroencephalography; Humans; Infant; Male; Malignant Hy | 2023 |
Predictors of outcome in prolonged posttraumatic disorders of consciousness and assessment of medication effects: A multicenter study.
Topics: Adult; Aged; Amantadine; Brain Injuries; Dantrolene; Data Collection; Disability Evaluation; Dopamin | 2005 |
Catatonia and neuroleptic malignant syndrome: two sides of a coin?
Topics: Adult; Aged; Alcoholism; Anticonvulsants; Antipsychotic Agents; Bipolar Disorder; Brain Injuries; Br | 2007 |
Seizures and brain injury in neonatal rats induced by 1S,3R-ACPD, a metabotropic glutamate receptor agonist.
Topics: Animals; Animals, Newborn; Anti-Anxiety Agents; Benzodiazepines; Brain Injuries; Cell Nucleus; Corpu | 1993 |