dantrolene has been researched along with Blood Poisoning in 14 studies
Dantrolene: Skeletal muscle relaxant that acts by interfering with excitation-contraction coupling in the muscle fiber. It is used in spasticity and other neuromuscular abnormalities. Although the mechanism of action is probably not central, dantrolene is usually grouped with the central muscle relaxants.
dantrolene : The hydrazone resulting from the formal condensation of 5-(4-nitrophenyl)furfural with 1-aminohydantoin. A ryanodine receptor antagonist used for the relief of chronic severe spasticity and malignant hyperthermia.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A middle-grade severity sepsis rat model was established for the effects of treatment with dantrolene, on diaphragm harvested 24 h after cecal ligation and puncture (CLP), and analyzed using functional, histologic, and biomarker assays." | 7.83 | Beneficial effects of dantrolene on sepsis-induced diaphragmatic dysfunction are associated with downregulation of high-mobility group box 1 and calpain-caspase-3 proteolytic pathway. ( Chen, D; Li, ST; Qiu, YW; Xu, MY, 2016) |
| "We conclude that dantrolene decreases survival in bacterial sepsis and has no effect on survival in endotoxemia in rats." | 7.69 | Dantrolene, an inhibitor of intracellular calcium release, fails to increase survival in a rat model of intra-abdominal sepsis. ( Cameron, EM; Fink, MP; Menconi, MJ; Phipps, R; Zhuang, J, 1996) |
| "Sepsis is the systemic inflammatory response resulting from serious infection and is the most common cause of death in intensive care units." | 5.29 | Dantrolene ameliorates the metabolic hallmarks of sepsis in rats and improves survival in a mouse model of endotoxemia. ( Hotchkiss, RS; Karl, IE, 1994) |
| " Thus, dantrolene administration was initiated with a tentative diagnosis of neuroleptic malignant syndrome (NMS)." | 3.91 | Neuroleptic malignant syndrome as part of an akinetic crisis associated with sepsis in a patient with Lewy body disease. ( Manabe, S; Ozawa, H; Takagi, A; Yanagi, H, 2019) |
| "A middle-grade severity sepsis rat model was established for the effects of treatment with dantrolene, on diaphragm harvested 24 h after cecal ligation and puncture (CLP), and analyzed using functional, histologic, and biomarker assays." | 3.83 | Beneficial effects of dantrolene on sepsis-induced diaphragmatic dysfunction are associated with downregulation of high-mobility group box 1 and calpain-caspase-3 proteolytic pathway. ( Chen, D; Li, ST; Qiu, YW; Xu, MY, 2016) |
| "The effects of dantrolene on serum TNFalpha and corticosterone levels and on muscle calcium, calpain gene expression, and protein breakdown were studied in rats with abdominal sepsis induced by cecal ligation and puncture." | 3.71 | Dantrolene reduces serum TNFalpha and corticosterone levels and muscle calcium, calpain gene expression, and protein breakdown in septic rats. ( Fischer, DR; Fischer, JE; Gang, G; Hasselgren, PO; James, JH; Molloy, M; Paul, RJ; Pritts, TA; Sun, X; Williams, AB, 2001) |
| "In previous studies, dantrolene prevented sepsis-induced muscle proteolysis, but the influence of dantrolene on the expression and activity of the ubiquitin-proteasome proteolytic pathway is not known." | 3.71 | Dantrolene downregulates the gene expression and activity of the ubiquitin-proteasome proteolytic pathway in septic skeletal muscle. ( Gang, GI; Hasselgren, PO; Sun, X; Wray, CJ, 2002) |
| "We conclude that dantrolene decreases survival in bacterial sepsis and has no effect on survival in endotoxemia in rats." | 3.69 | Dantrolene, an inhibitor of intracellular calcium release, fails to increase survival in a rat model of intra-abdominal sepsis. ( Cameron, EM; Fink, MP; Menconi, MJ; Phipps, R; Zhuang, J, 1996) |
| "Dantrolene was administered to 304 inpatients." | 1.72 | Intravenous dantrolene in hypermetabolic syndromes: a survey of the U.S. Veterans Health Administration database. ( Berkowitz, RM; Caroff, SN; Mashman, D; Riazi, S; Roberts, CB; Rosenberg, H; Tobin, JR; Watt, S, 2022) |
| "Sepsis was induced by injection of endotoxin lipopolysaccharide (10 mg/kg/intravenously)." | 1.35 | Prevention of endotoxin-induced sarcoplasmic reticulum calcium leak improves mitochondrial and myocardial dysfunction. ( Bouazza, Y; Decoster, B; Hassoun, SM; Lancel, S; Marechal, X; Montaigne, D; Neviere, R, 2008) |
| "Sepsis was associated with a significant increase in erythrocyte intracellular calcium concentration as compared with nonseptic controls (96." | 1.29 | Effect of sepsis on erythrocyte intracellular calcium homeostasis. ( Mollitt, DL; Todd, JC, 1995) |
| "Sepsis is the systemic inflammatory response resulting from serious infection and is the most common cause of death in intensive care units." | 1.29 | Dantrolene ameliorates the metabolic hallmarks of sepsis in rats and improves survival in a mouse model of endotoxemia. ( Hotchkiss, RS; Karl, IE, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (35.71) | 18.2507 |
| 2000's | 3 (21.43) | 29.6817 |
| 2010's | 4 (28.57) | 24.3611 |
| 2020's | 2 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Caroff, SN | 1 |
| Roberts, CB | 1 |
| Rosenberg, H | 1 |
| Tobin, JR | 1 |
| Watt, S | 1 |
| Mashman, D | 1 |
| Riazi, S | 1 |
| Berkowitz, RM | 1 |
| Wei, H | 1 |
| Liang, G | 1 |
| Vera, RM | 1 |
| Manabe, S | 1 |
| Yanagi, H | 1 |
| Ozawa, H | 1 |
| Takagi, A | 1 |
| Celes, MR | 1 |
| Malvestio, LM | 1 |
| Suadicani, SO | 1 |
| Prado, CM | 1 |
| Figueiredo, MJ | 1 |
| Campos, EC | 1 |
| Freitas, AC | 1 |
| Spray, DC | 1 |
| Tanowitz, HB | 1 |
| da Silva, JS | 1 |
| Rossi, MA | 1 |
| Qiu, YW | 1 |
| Chen, D | 1 |
| Xu, MY | 1 |
| Li, ST | 1 |
| Hassoun, SM | 1 |
| Marechal, X | 1 |
| Montaigne, D | 1 |
| Bouazza, Y | 1 |
| Decoster, B | 1 |
| Lancel, S | 1 |
| Neviere, R | 1 |
| Setzer-Saade, N | 1 |
| Todd, JC | 1 |
| Mollitt, DL | 1 |
| Hotchkiss, RS | 2 |
| Karl, IE | 2 |
| Song, SK | 1 |
| Ackerman, JJ | 1 |
| Cameron, EM | 1 |
| Zhuang, J | 1 |
| Menconi, MJ | 1 |
| Phipps, R | 1 |
| Fink, MP | 1 |
| Strecker, G | 1 |
| Adnet, P | 1 |
| Forget, AP | 1 |
| Krivosic-Horber, R | 1 |
| Fischer, DR | 1 |
| Sun, X | 2 |
| Williams, AB | 1 |
| Gang, G | 1 |
| Pritts, TA | 1 |
| James, JH | 1 |
| Molloy, M | 1 |
| Fischer, JE | 1 |
| Paul, RJ | 1 |
| Hasselgren, PO | 2 |
| Wray, CJ | 1 |
| Gang, GI | 1 |
1 review available for dantrolene and Blood Poisoning
| Article | Year |
|---|---|
Dantrolene repurposed to treat sepsis or septic shock and COVID-19 patients.
Topics: Calcium; Calcium Channel Blockers; COVID-19; COVID-19 Drug Treatment; Dantrolene; Drug Repositioning | 2021 |
13 other studies available for dantrolene and Blood Poisoning
| Article | Year |
|---|---|
Intravenous dantrolene in hypermetabolic syndromes: a survey of the U.S. Veterans Health Administration database.
Topics: Creatine Kinase; Dantrolene; Humans; Malignant Hyperthermia; Retrospective Studies; Sepsis; Veterans | 2022 |
Neuroleptic malignant syndrome as part of an akinetic crisis associated with sepsis in a patient with Lewy body disease.
Topics: Aged; Anti-Bacterial Agents; Dantrolene; Diagnosis, Differential; Female; Fluid Therapy; Humans; Lew | 2019 |
Disruption of calcium homeostasis in cardiomyocytes underlies cardiac structural and functional changes in severe sepsis.
Topics: Actins; Animals; Animals, Newborn; Blotting, Western; Calcium; Calpain; Cecum; Cells, Cultured; Dant | 2013 |
Beneficial effects of dantrolene on sepsis-induced diaphragmatic dysfunction are associated with downregulation of high-mobility group box 1 and calpain-caspase-3 proteolytic pathway.
Topics: Animals; Biomarkers; Calpain; Caspase 3; Dantrolene; Diaphragm; Dose-Response Relationship, Drug; Do | 2016 |
Prevention of endotoxin-induced sarcoplasmic reticulum calcium leak improves mitochondrial and myocardial dysfunction.
Topics: Animals; Caffeine; Calcium; Cardiac Output; Dantrolene; Dose-Response Relationship, Drug; In Vitro T | 2008 |
Malignant hyperthermia in the absence of triggering agents.
Topics: Anesthesia; Anesthetics; Body Temperature; Child, Preschool; Dantrolene; Female; Humans; Malignant H | 2010 |
Effect of sepsis on erythrocyte intracellular calcium homeostasis.
Topics: Adenosine; Adenosine Triphosphate; Adolescent; Adult; Aged; Calcium; Dantrolene; Endotoxins; Erythro | 1995 |
Dantrolene ameliorates the metabolic hallmarks of sepsis in rats and improves survival in a mouse model of endotoxemia.
Topics: Animals; Calcium; Dantrolene; Female; Glucose; Mice; Proteins; Rats; Rats, Sprague-Dawley; Sepsis; S | 1994 |
Increased intracellular Ca2+: a critical link in the pathophysiology of sepsis?
Topics: Animals; Aorta, Thoracic; Calcium; Chelating Agents; Dantrolene; Disease Models, Animal; Egtazic Aci | 1993 |
Dantrolene, an inhibitor of intracellular calcium release, fails to increase survival in a rat model of intra-abdominal sepsis.
Topics: Animals; Calcium; Dantrolene; Disease Models, Animal; Escherichia coli Infections; Lactates; Male; P | 1996 |
[Malignant hyperthermia and appendicular sepsis. Can they be differentiated during surgical procedure?].
Topics: Adolescent; Adult; Appendicitis; Child; Dantrolene; Diagnosis, Differential; Female; Fever; Humans; | 1997 |
Dantrolene reduces serum TNFalpha and corticosterone levels and muscle calcium, calpain gene expression, and protein breakdown in septic rats.
Topics: Animals; Calcium; Calpain; Corticosterone; Dantrolene; Male; Muscle Proteins; Muscle Relaxants, Cent | 2001 |
Dantrolene downregulates the gene expression and activity of the ubiquitin-proteasome proteolytic pathway in septic skeletal muscle.
Topics: Animals; Calcium; Cecum; Chymotrypsin; Corticosterone; Cysteine Endopeptidases; Dantrolene; Gene Exp | 2002 |