Page last updated: 2024-10-25

dantrolene and Aura

dantrolene has been researched along with Aura in 8 studies

Dantrolene: Skeletal muscle relaxant that acts by interfering with excitation-contraction coupling in the muscle fiber. It is used in spasticity and other neuromuscular abnormalities. Although the mechanism of action is probably not central, dantrolene is usually grouped with the central muscle relaxants.
dantrolene : The hydrazone resulting from the formal condensation of 5-(4-nitrophenyl)furfural with 1-aminohydantoin. A ryanodine receptor antagonist used for the relief of chronic severe spasticity and malignant hyperthermia.

Research Excerpts

ExcerptRelevanceReference
"In this two-phase study, 21 pediatric patients with epilepsy and spasticity were initially treated with dantrolene sodium suspension and, after a washout period, began a double-blind portion where one half received dantrolene sodium suspension and the other half received a placebo suspension."9.04Effect of dantrolene sodium on the incidence of seizures in children with spasticity. ( Nogen, AG, 1979)
"Status epilepticus is a clinical emergency that can lead to the development of acquired epilepsy following neuronal injury."5.36Dantrolene inhibits the calcium plateau and prevents the development of spontaneous recurrent epileptiform discharges following in vitro status epilepticus. ( Carter, DS; DeLorenzo, RJ; Deshpande, LS; Nagarkatti, N, 2010)
"Dantrolene has an inhibitory action against Ca(2+) release from intracellular Ca(2+) stores."5.33Dantrolene, a calcium-induced calcium release inhibitor, prevents the acquisition of amygdaloid kindling in rats, a model of experimental epilepsy. ( Sakai, T; Yoshida, M, 2006)
"In this two-phase study, 21 pediatric patients with epilepsy and spasticity were initially treated with dantrolene sodium suspension and, after a washout period, began a double-blind portion where one half received dantrolene sodium suspension and the other half received a placebo suspension."5.04Effect of dantrolene sodium on the incidence of seizures in children with spasticity. ( Nogen, AG, 1979)
"We report the effects of two new dihydropyridine derivatives, isradipine (4-(4'-benzofurazanyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedic arboxylic acid methylisopropylester) and niguldipine (1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinecarboxylic acid 3-(4,4-diphenyl-1-piperidinyl)-propyl methyl ester hydrochloride), and of dantrolene (1-[(5-[p-nitrophenyl]furfurylidene)-amino]hydantoin sodium, an inhibitor of Ca2+ release from intracellular stores) on the protective efficacy of antiepileptic drugs against maximal electroshock-induced seizures."3.69Influence of isradipine, niguldipine and dantrolene on the anticonvulsive action of conventional antiepileptics in mice. ( Borowicz, KK; Czuczwar, SJ; Gasior, M; Kleinrok, Z, 1997)
"Status epilepticus is a clinical emergency that can lead to the development of acquired epilepsy following neuronal injury."1.36Dantrolene inhibits the calcium plateau and prevents the development of spontaneous recurrent epileptiform discharges following in vitro status epilepticus. ( Carter, DS; DeLorenzo, RJ; Deshpande, LS; Nagarkatti, N, 2010)
"Dantrolene has an inhibitory action against Ca(2+) release from intracellular Ca(2+) stores."1.33Dantrolene, a calcium-induced calcium release inhibitor, prevents the acquisition of amygdaloid kindling in rats, a model of experimental epilepsy. ( Sakai, T; Yoshida, M, 2006)

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19902 (25.00)18.7374
1990's2 (25.00)18.2507
2000's3 (37.50)29.6817
2010's1 (12.50)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Nagarkatti, N1
Deshpande, LS1
Carter, DS1
DeLorenzo, RJ1
Rutecki, PA1
Sayin, U1
Yang, Y1
Hadar, E1
Mazarati, A1
Lundström, L1
Sollenberg, U1
Shin, D1
Langel, U1
Sankar, R1
Yoshida, M1
Sakai, T1
Delacour, JL1
Daoudal, P1
Chapoutot, JL1
Rocq, B1
Borowicz, KK1
Gasior, M1
Kleinrok, Z1
Czuczwar, SJ1
Yang, L1
Benardo, LS1
Nogen, AG1

Trials

1 trial available for dantrolene and Aura

ArticleYear
Effect of dantrolene sodium on the incidence of seizures in children with spasticity.
    Child's brain, 1979, Volume: 5, Issue:4

    Topics: Adolescent; Anticonvulsants; Cerebral Palsy; Child; Child, Preschool; Clinical Trials as Topic; Dant

1979

Other Studies

7 other studies available for dantrolene and Aura

ArticleYear
Dantrolene inhibits the calcium plateau and prevents the development of spontaneous recurrent epileptiform discharges following in vitro status epilepticus.
    The European journal of neuroscience, 2010, Volume: 32, Issue:1

    Topics: Animals; Calcium; Cell Death; Cells, Cultured; Dantrolene; Dizocilpine Maleate; Epilepsy; Excitatory

2010
Determinants of ictal epileptiform patterns in the hippocampal slice.
    Epilepsia, 2002, Volume: 43 Suppl 5

    Topics: Animals; Calcium; Calcium Channels, L-Type; Dantrolene; Electrophysiology; Enzyme Inhibitors; Epilep

2002
Regulation of kindling epileptogenesis by hippocampal galanin type 1 and type 2 receptors: The effects of subtype-selective agonists and the role of G-protein-mediated signaling.
    The Journal of pharmacology and experimental therapeutics, 2006, Volume: 318, Issue:2

    Topics: Animals; Anticonvulsants; Bee Venoms; Calcium Signaling; Dantrolene; Electric Stimulation; Epilepsy;

2006
Dantrolene, a calcium-induced calcium release inhibitor, prevents the acquisition of amygdaloid kindling in rats, a model of experimental epilepsy.
    The Tohoku journal of experimental medicine, 2006, Volume: 209, Issue:4

    Topics: Animals; Calcium; Dantrolene; Disease Models, Animal; Epilepsy; Kindling, Neurologic; Male; Rats; Ra

2006
[Therapy of neuroleptic malignant syndrome with dantrolene].
    La Nouvelle presse medicale, 1981, Nov-28, Volume: 10, Issue:43

    Topics: Adult; Antipsychotic Agents; Dantrolene; Epilepsy; Humans; Male; Nervous System Diseases; Syndrome

1981
Influence of isradipine, niguldipine and dantrolene on the anticonvulsive action of conventional antiepileptics in mice.
    European journal of pharmacology, 1997, Mar-26, Volume: 323, Issue:1

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e

1997
Epileptogenesis following neocortical trauma from two sources of disinhibition.
    Journal of neurophysiology, 1997, Volume: 78, Issue:5

    Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Calcium; Cell Membrane; Chelating Agents; Dantrolene;

1997