Page last updated: 2024-10-25

dantrolene and Atrophy

dantrolene has been researched along with Atrophy in 2 studies

Dantrolene: Skeletal muscle relaxant that acts by interfering with excitation-contraction coupling in the muscle fiber. It is used in spasticity and other neuromuscular abnormalities. Although the mechanism of action is probably not central, dantrolene is usually grouped with the central muscle relaxants.
dantrolene : The hydrazone resulting from the formal condensation of 5-(4-nitrophenyl)furfural with 1-aminohydantoin. A ryanodine receptor antagonist used for the relief of chronic severe spasticity and malignant hyperthermia.

Atrophy: Decrease in the size of a cell, tissue, organ, or multiple organs, associated with a variety of pathological conditions such as abnormal cellular changes, ischemia, malnutrition, or hormonal changes.

Research Excerpts

ExcerptRelevanceReference
" Long-term feeding of the RyanR inhibitor dantrolene to amyloid precursor protein-presenilin-1 mice (Thy1-APP(KM670/671NL), Thy1-PS1(L166P)) resulted in an increased amyloid load, loss of synaptic markers, and neuronal atrophy in hippocampal and cortical regions."3.76Role of presenilins in neuronal calcium homeostasis. ( Bezprozvanny, I; De Strooper, B; Herreman, A; Sun, S; Zhang, H, 2010)

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's2 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Zhang, H1
Sun, S1
Herreman, A1
De Strooper, B1
Bezprozvanny, I1
Narumi, Y1
Shiihara, T1
Yoshihashi, H1
Sakazume, S1
van der Knaap, MS1
Nishimura-Tadaki, A1
Matsumoto, N1
Fukushima, Y1

Other Studies

2 other studies available for dantrolene and Atrophy

ArticleYear
Role of presenilins in neuronal calcium homeostasis.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010, Jun-23, Volume: 30, Issue:25

    Topics: Amyloid beta-Peptides; Analysis of Variance; Animals; Atrophy; Calcium; Cells, Cultured; Corpus Stri

2010
Hypomyelination with atrophy of the basal ganglia and cerebellum in an infant with Down syndrome.
    Clinical dysmorphology, 2011, Volume: 20, Issue:3

    Topics: Atrophy; Basal Ganglia; Brain Diseases; Cerebellum; Dantrolene; Down Syndrome; Humans; Infant; Magne

2011