dantrolene has been researched along with Atrophy in 2 studies
Dantrolene: Skeletal muscle relaxant that acts by interfering with excitation-contraction coupling in the muscle fiber. It is used in spasticity and other neuromuscular abnormalities. Although the mechanism of action is probably not central, dantrolene is usually grouped with the central muscle relaxants.
dantrolene : The hydrazone resulting from the formal condensation of 5-(4-nitrophenyl)furfural with 1-aminohydantoin. A ryanodine receptor antagonist used for the relief of chronic severe spasticity and malignant hyperthermia.
Atrophy: Decrease in the size of a cell, tissue, organ, or multiple organs, associated with a variety of pathological conditions such as abnormal cellular changes, ischemia, malnutrition, or hormonal changes.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Long-term feeding of the RyanR inhibitor dantrolene to amyloid precursor protein-presenilin-1 mice (Thy1-APP(KM670/671NL), Thy1-PS1(L166P)) resulted in an increased amyloid load, loss of synaptic markers, and neuronal atrophy in hippocampal and cortical regions." | 3.76 | Role of presenilins in neuronal calcium homeostasis. ( Bezprozvanny, I; De Strooper, B; Herreman, A; Sun, S; Zhang, H, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, H | 1 |
| Sun, S | 1 |
| Herreman, A | 1 |
| De Strooper, B | 1 |
| Bezprozvanny, I | 1 |
| Narumi, Y | 1 |
| Shiihara, T | 1 |
| Yoshihashi, H | 1 |
| Sakazume, S | 1 |
| van der Knaap, MS | 1 |
| Nishimura-Tadaki, A | 1 |
| Matsumoto, N | 1 |
| Fukushima, Y | 1 |
2 other studies available for dantrolene and Atrophy
| Article | Year |
|---|---|
Role of presenilins in neuronal calcium homeostasis.
Topics: Amyloid beta-Peptides; Analysis of Variance; Animals; Atrophy; Calcium; Cells, Cultured; Corpus Stri | 2010 |
Hypomyelination with atrophy of the basal ganglia and cerebellum in an infant with Down syndrome.
Topics: Atrophy; Basal Ganglia; Brain Diseases; Cerebellum; Dantrolene; Down Syndrome; Humans; Infant; Magne | 2011 |