dantrolene has been researched along with Atrial Fibrillation in 4 studies
Dantrolene: Skeletal muscle relaxant that acts by interfering with excitation-contraction coupling in the muscle fiber. It is used in spasticity and other neuromuscular abnormalities. Although the mechanism of action is probably not central, dantrolene is usually grouped with the central muscle relaxants.
dantrolene : The hydrazone resulting from the formal condensation of 5-(4-nitrophenyl)furfural with 1-aminohydantoin. A ryanodine receptor antagonist used for the relief of chronic severe spasticity and malignant hyperthermia.
Atrial Fibrillation: Abnormal cardiac rhythm that is characterized by rapid, uncoordinated firing of electrical impulses in the upper chambers of the heart (HEART ATRIA). In such case, blood cannot be effectively pumped into the lower chambers of the heart (HEART VENTRICLES). It is caused by abnormal impulse generation.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Stabilizing RyR with chronic dantrolene treatment does not affect hypertension development in SHR." | 7.96 | Chronic Dantrolene Treatment Does Not Affect Hypertension, but Attenuates Sympathetic Stimulation Enhanced Atrial Fibrillation Inducibility in SHR. ( Gerdes, AM; Greco, L; Lee, JS; Li, Y; Migirov, A; Zhang, Y, 2020) |
| "Dantrolene treatment significantly reduced both AF inducibility (2/9 in dantrolene group, P < 0." | 5.72 | Stabilizing Cardiac Ryanodine Receptor With Dantrolene Treatment Prevents Binge Alcohol-Enhanced Atrial Fibrillation in Rats. ( Cohen, TJ; Greco, LV; Huang, Y; Kobayashi, S; Li, Y; Migirov, A; Ojamaa, K; Stout, R; Udo-Bellner, L; Zhang, Y, 2022) |
| "Stabilizing RyR with chronic dantrolene treatment does not affect hypertension development in SHR." | 3.96 | Chronic Dantrolene Treatment Does Not Affect Hypertension, but Attenuates Sympathetic Stimulation Enhanced Atrial Fibrillation Inducibility in SHR. ( Gerdes, AM; Greco, L; Lee, JS; Li, Y; Migirov, A; Zhang, Y, 2020) |
| "The purpose of this study was to investigate the effects of dantrolene on arrhythmogenic triggers and contractile function in human atrial fibrillation (AF) and HF cardiomyocytes (CM)." | 3.85 | Antiarrhythmic effects of dantrolene in human diseased cardiomyocytes. ( Danner, BC; Fischer, TH; Frey, N; Gummert, J; Hartmann, N; Hasenfuss, G; Herting, J; Maier, LS; Pabel, S; Renner, A; Schatter, F; Schotola, H; Sossalla, S, 2017) |
| "Dantrolene treatment significantly reduced both AF inducibility (2/9 in dantrolene group, P < 0." | 1.72 | Stabilizing Cardiac Ryanodine Receptor With Dantrolene Treatment Prevents Binge Alcohol-Enhanced Atrial Fibrillation in Rats. ( Cohen, TJ; Greco, LV; Huang, Y; Kobayashi, S; Li, Y; Migirov, A; Ojamaa, K; Stout, R; Udo-Bellner, L; Zhang, Y, 2022) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 2 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Greco, LV | 1 |
| Migirov, A | 2 |
| Ojamaa, K | 1 |
| Li, Y | 3 |
| Huang, Y | 1 |
| Kobayashi, S | 1 |
| Udo-Bellner, L | 1 |
| Stout, R | 1 |
| Cohen, TJ | 1 |
| Zhang, Y | 3 |
| Lee, JS | 1 |
| Greco, L | 1 |
| Gerdes, AM | 2 |
| Delfiner, MS | 1 |
| Nofi, C | 1 |
| Hartmann, N | 1 |
| Pabel, S | 1 |
| Herting, J | 1 |
| Schatter, F | 1 |
| Renner, A | 1 |
| Gummert, J | 1 |
| Schotola, H | 1 |
| Danner, BC | 1 |
| Maier, LS | 1 |
| Frey, N | 1 |
| Hasenfuss, G | 1 |
| Fischer, TH | 1 |
| Sossalla, S | 1 |
4 other studies available for dantrolene and Atrial Fibrillation
| Article | Year |
|---|---|
Stabilizing Cardiac Ryanodine Receptor With Dantrolene Treatment Prevents Binge Alcohol-Enhanced Atrial Fibrillation in Rats.
Topics: Animals; Atrial Fibrillation; Binge Drinking; Calcium; Dantrolene; Ethanol; Heart Atria; Myocytes, C | 2022 |
Chronic Dantrolene Treatment Does Not Affect Hypertension, but Attenuates Sympathetic Stimulation Enhanced Atrial Fibrillation Inducibility in SHR.
Topics: Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; Blood Pressure; Dantrolene; Disease Models, An | 2020 |
Failing Hearts Are More Vulnerable to Sympathetic, but Not Vagal Stimulation-Induced, Atrial Fibrillation-Ameliorated with Dantrolene Treatment.
Topics: Animals; Atrial Fibrillation; Dantrolene; Disease Models, Animal; Electric Stimulation Therapy; Hear | 2018 |
Antiarrhythmic effects of dantrolene in human diseased cardiomyocytes.
Topics: Action Potentials; Anti-Arrhythmia Agents; Atrial Fibrillation; Calcium Signaling; Cells, Cultured; | 2017 |