dantrolene has been researched along with Amyotrophic Lateral Sclerosis in 4 studies
Dantrolene: Skeletal muscle relaxant that acts by interfering with excitation-contraction coupling in the muscle fiber. It is used in spasticity and other neuromuscular abnormalities. Although the mechanism of action is probably not central, dantrolene is usually grouped with the central muscle relaxants.
dantrolene : The hydrazone resulting from the formal condensation of 5-(4-nitrophenyl)furfural with 1-aminohydantoin. A ryanodine receptor antagonist used for the relief of chronic severe spasticity and malignant hyperthermia.
Amyotrophic Lateral Sclerosis: A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts. (From Adams et al., Principles of Neurology, 6th ed, pp1089-94)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (75.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Staats, KA | 1 |
| Van Rillaer, M | 1 |
| Scheveneels, W | 1 |
| Verbesselt, R | 1 |
| Van Damme, P | 1 |
| Robberecht, W | 1 |
| Van Den Bosch, L | 1 |
| Khondkarian, OA | 1 |
| Zavalishin, IA | 1 |
| Novikova, VP | 1 |
| Goldblatt, D | 1 |
| Rivera, VM | 1 |
| Breitbach, WB | 1 |
| Swanke, L | 1 |
4 other studies available for dantrolene and Amyotrophic Lateral Sclerosis
| Article | Year |
|---|---|
Dantrolene is neuroprotective in vitro, but does not affect survival in SOD1(G⁹³A) mice.
Topics: Amyotrophic Lateral Sclerosis; Animals; Calcium; Dantrolene; Disease Models, Animal; Humans; Immunoh | 2012 |
[Muscle spasms in patients with amyotrophic lateral sclerosis (clinico-electromyographnic analysis)].
Topics: Amyotrophic Lateral Sclerosis; Carisoprodol; Dantrolene; Electromyography; Humans; Motor Neurons; Mo | 1979 |
Treatment of amyotrophic lateral sclerosis.
Topics: Aging; Amitriptyline; Amyotrophic Lateral Sclerosis; Baclofen; Braces; Dantrolene; Deglutition Disor | 1977 |
Letter: Dantrolene in amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Dantrolene; Drug Tolerance; Humans; Hydantoins | 1975 |