dantrolene has been researched along with Amyloid Deposits in 2 studies
Dantrolene: Skeletal muscle relaxant that acts by interfering with excitation-contraction coupling in the muscle fiber. It is used in spasticity and other neuromuscular abnormalities. Although the mechanism of action is probably not central, dantrolene is usually grouped with the central muscle relaxants.
dantrolene : The hydrazone resulting from the formal condensation of 5-(4-nitrophenyl)furfural with 1-aminohydantoin. A ryanodine receptor antagonist used for the relief of chronic severe spasticity and malignant hyperthermia.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Dantrolene treatment for 11 months significantly reduced both memory deficits and amyloid plaque load in the hippocampus in 13-month-old 3xTg-AD mice." | 1.38 | Dantrolene ameliorates cognitive decline and neuropathology in Alzheimer triple transgenic mice. ( Eckenhoff, MF; Inan, S; Joseph, DJ; Liang, G; Meng, Q; Peng, J; Peng, Y; Wei, H; Wu, Z, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Peng, J | 1 |
| Liang, G | 1 |
| Inan, S | 1 |
| Wu, Z | 1 |
| Joseph, DJ | 1 |
| Meng, Q | 1 |
| Peng, Y | 1 |
| Eckenhoff, MF | 1 |
| Wei, H | 1 |
| Oulès, B | 1 |
| Del Prete, D | 1 |
| Greco, B | 1 |
| Zhang, X | 1 |
| Lauritzen, I | 1 |
| Sevalle, J | 1 |
| Moreno, S | 1 |
| Paterlini-Bréchot, P | 1 |
| Trebak, M | 1 |
| Checler, F | 1 |
| Benfenati, F | 1 |
| Chami, M | 1 |
2 other studies available for dantrolene and Amyloid Deposits
| Article | Year |
|---|---|
Dantrolene ameliorates cognitive decline and neuropathology in Alzheimer triple transgenic mice.
Topics: Alzheimer Disease; Animals; Blotting, Western; Cognition Disorders; Dantrolene; Disease Models, Anim | 2012 |
Ryanodine receptor blockade reduces amyloid-β load and memory impairments in Tg2576 mouse model of Alzheimer disease.
Topics: Alzheimer Disease; Aminophenols; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Prec | 2012 |