dantrolene has been researched along with Akinetic-Rigid Variant of Huntington Disease in 3 studies
Dantrolene: Skeletal muscle relaxant that acts by interfering with excitation-contraction coupling in the muscle fiber. It is used in spasticity and other neuromuscular abnormalities. Although the mechanism of action is probably not central, dantrolene is usually grouped with the central muscle relaxants.
dantrolene : The hydrazone resulting from the formal condensation of 5-(4-nitrophenyl)furfural with 1-aminohydantoin. A ryanodine receptor antagonist used for the relief of chronic severe spasticity and malignant hyperthermia.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pre-treatment with dantrolene protected YAC128 MSNs from glutamate excitotoxicty, with an effective concentration of 100 nM and above." | 1.37 | Dantrolene is neuroprotective in Huntington's disease transgenic mouse model. ( Bezprozvanny, I; Chen, X; Herndon, E; Lvovskaya, S; Supnet, C; Wu, J, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (66.67) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, X | 1 |
| Wu, J | 1 |
| Lvovskaya, S | 1 |
| Herndon, E | 1 |
| Supnet, C | 1 |
| Bezprozvanny, I | 1 |
| Paulson, GW | 1 |
| Feit, H | 1 |
3 other studies available for dantrolene and Akinetic-Rigid Variant of Huntington Disease
| Article | Year |
|---|---|
Dantrolene is neuroprotective in Huntington's disease transgenic mouse model.
Topics: Animals; Apoptosis; Caffeine; Calcium; Calcium Signaling; Cells, Cultured; Central Nervous System St | 2011 |
Lioresal in Huntington's disease.
Topics: Aminobutyrates; Baclofen; Dantrolene; Diazepam; Drug Evaluation; Gait; gamma-Aminobutyric Acid; Grow | 1976 |
A form of chorea that responds to dantrolene sodium.
Topics: Adult; Carbamazepine; Dantrolene; Female; Humans; Huntington Disease; Seizures | 1979 |