dantrolene and Aging
dantrolene has been researched along with Aging in 7 studies
Dantrolene: Skeletal muscle relaxant that acts by interfering with excitation-contraction coupling in the muscle fiber. It is used in spasticity and other neuromuscular abnormalities. Although the mechanism of action is probably not central, dantrolene is usually grouped with the central muscle relaxants.
dantrolene : The hydrazone resulting from the formal condensation of 5-(4-nitrophenyl)furfural with 1-aminohydantoin. A ryanodine receptor antagonist used for the relief of chronic severe spasticity and malignant hyperthermia.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
Research
Studies (7)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (28.57) | 18.7374 |
| 1990's | 1 (14.29) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 3 (42.86) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Domeier, TL | 1 |
| Roberts, CJ | 1 |
| Gibson, AK | 1 |
| Hanft, LM | 1 |
| McDonald, KS | 1 |
| Segal, SS | 1 |
| Hopp, SC | 1 |
| D'Angelo, HM | 1 |
| Royer, SE | 1 |
| Kaercher, RM | 1 |
| Adzovic, L | 1 |
| Wenk, GL | 1 |
| Drake, TM | 1 |
| Wang, JH | 1 |
| Kelly, PT | 1 |
| Orliaguet, G | 1 |
| Langeron, O | 1 |
| Coirault, C | 1 |
| Fratea, S | 1 |
| Coriat, P | 1 |
| Riou, B | 1 |
| Goldblatt, D | 1 |
| James, OF | 1 |
Reviews
1 review available for dantrolene and Aging
| Article | Year |
|---|---|
Drugs and the ageing liver.
Topics: Aged; Aging; Biotransformation; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Syst | 1985 |
Other Studies
6 other studies available for dantrolene and Aging
| Article | Year |
|---|---|
Dantrolene suppresses spontaneous Ca2+ release without altering excitation-contraction coupling in cardiomyocytes of aged mice.
Topics: Action Potentials; Adrenergic beta-Agonists; Age Factors; Aging; Animals; Anti-Arrhythmia Agents; Ca | 2014 |
Differential rescue of spatial memory deficits in aged rats by L-type voltage-dependent calcium channel and ryanodine receptor antagonism.
Topics: Aging; Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Dantrolene; Gene Expression; Hip | 2014 |
Unfolding the promise of translational targeting in neurodegenerative disease.
Topics: Activating Transcription Factor 6; Aging; Animals; Apoptosis; Cellular Microenvironment; Dantrolene; | 2015 |
Postsynaptic calcineurin activity downregulates synaptic transmission by weakening intracellular Ca2+ signaling mechanisms in hippocampal CA1 neurons.
Topics: Aging; Animals; Calcineurin; Calcium; Calmodulin-Binding Proteins; Dantrolene; Egtazic Acid; Electri | 1997 |
Effects of dantrolene on rat diaphragm muscle during postnatal maturation.
Topics: Aging; Animals; Animals, Newborn; Biomechanical Phenomena; Dantrolene; Diaphragm; Muscle Contraction | 2001 |
Treatment of amyotrophic lateral sclerosis.
Topics: Aging; Amitriptyline; Amyotrophic Lateral Sclerosis; Baclofen; Braces; Dantrolene; Deglutition Disor | 1977 |