dantrolene has been researched along with Age-Related Memory Disorders in 5 studies
Dantrolene: Skeletal muscle relaxant that acts by interfering with excitation-contraction coupling in the muscle fiber. It is used in spasticity and other neuromuscular abnormalities. Although the mechanism of action is probably not central, dantrolene is usually grouped with the central muscle relaxants.
dantrolene : The hydrazone resulting from the formal condensation of 5-(4-nitrophenyl)furfural with 1-aminohydantoin. A ryanodine receptor antagonist used for the relief of chronic severe spasticity and malignant hyperthermia.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Dantrolene treatment had no significant change in the amyloid burden or synaptic proteins and no significant side effects on mortality, olfaction, motor, or liver functions in 5XFAD mice." | 1.56 | Intranasal Dantrolene as a Disease-Modifying Drug in Alzheimer 5XFAD Mice. ( Ben Abou, M; Eckenhoff, MF; Gao, X; Hepner, A; Liang, G; Meng, Q; Shi, Y; Wei, H; Zhang, J; Zhang, L, 2020) |
| "LPS-infused rats had significant memory deficits in the Morris water maze, and this deficit was ameliorated by treatment with nimodipine." | 1.42 | Calcium dysregulation via L-type voltage-dependent calcium channels and ryanodine receptors underlies memory deficits and synaptic dysfunction during chronic neuroinflammation. ( Adzovic, L; Crockett, AM; D'Angelo, HM; Hopp, SC; Kaercher, RM; Royer, SE; Wenk, GL, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (60.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Shi, Y | 1 |
| Zhang, L | 1 |
| Gao, X | 1 |
| Zhang, J | 1 |
| Ben Abou, M | 1 |
| Liang, G | 1 |
| Meng, Q | 1 |
| Hepner, A | 1 |
| Eckenhoff, MF | 1 |
| Wei, H | 1 |
| Hopp, SC | 2 |
| D'Angelo, HM | 2 |
| Royer, SE | 2 |
| Kaercher, RM | 2 |
| Adzovic, L | 2 |
| Wenk, GL | 2 |
| Crockett, AM | 1 |
| Oulès, B | 1 |
| Del Prete, D | 1 |
| Greco, B | 1 |
| Zhang, X | 1 |
| Lauritzen, I | 1 |
| Sevalle, J | 1 |
| Moreno, S | 1 |
| Paterlini-Bréchot, P | 1 |
| Trebak, M | 1 |
| Checler, F | 1 |
| Benfenati, F | 1 |
| Chami, M | 1 |
| Ohnuki, T | 1 |
| Nomura, Y | 1 |
5 other studies available for dantrolene and Age-Related Memory Disorders
| Article | Year |
|---|---|
Intranasal Dantrolene as a Disease-Modifying Drug in Alzheimer 5XFAD Mice.
Topics: Administration, Intranasal; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Brain; Dantr | 2020 |
Differential rescue of spatial memory deficits in aged rats by L-type voltage-dependent calcium channel and ryanodine receptor antagonism.
Topics: Aging; Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Dantrolene; Gene Expression; Hip | 2014 |
Calcium dysregulation via L-type voltage-dependent calcium channels and ryanodine receptors underlies memory deficits and synaptic dysfunction during chronic neuroinflammation.
Topics: AIDS-Related Complex; Analysis of Variance; Animals; Calcium; Calcium Channel Blockers; Calcium Chan | 2015 |
Ryanodine receptor blockade reduces amyloid-β load and memory impairments in Tg2576 mouse model of Alzheimer disease.
Topics: Alzheimer Disease; Aminophenols; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Prec | 2012 |
1-[[[5-(4-Nitrophenyl)-2-furanyl]methylene]imino]-2,4-imidazolidinedione (dantrolene), an inhibitor of intracellular Ca2+ mobilization, impairs avoidance performance and spatial memory in mice.
Topics: Adenosine Diphosphate Ribose; Animals; Avoidance Learning; Calcium; Cyclic ADP-Ribose; Dantrolene; M | 1996 |