dantrolene has been researched along with Acute Confusional Senile Dementia in 14 studies
Dantrolene: Skeletal muscle relaxant that acts by interfering with excitation-contraction coupling in the muscle fiber. It is used in spasticity and other neuromuscular abnormalities. Although the mechanism of action is probably not central, dantrolene is usually grouped with the central muscle relaxants.
dantrolene : The hydrazone resulting from the formal condensation of 5-(4-nitrophenyl)furfural with 1-aminohydantoin. A ryanodine receptor antagonist used for the relief of chronic severe spasticity and malignant hyperthermia.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Dantrolene treatment had no significant change in the amyloid burden or synaptic proteins and no significant side effects on mortality, olfaction, motor, or liver functions in 5XFAD mice." | 1.56 | Intranasal Dantrolene as a Disease-Modifying Drug in Alzheimer 5XFAD Mice. ( Ben Abou, M; Eckenhoff, MF; Gao, X; Hepner, A; Liang, G; Meng, Q; Shi, Y; Wei, H; Zhang, J; Zhang, L, 2020) |
| "Dantrolene treatment for 11 months significantly reduced both memory deficits and amyloid plaque load in the hippocampus in 13-month-old 3xTg-AD mice." | 1.38 | Dantrolene ameliorates cognitive decline and neuropathology in Alzheimer triple transgenic mice. ( Eckenhoff, MF; Inan, S; Joseph, DJ; Liang, G; Meng, Q; Peng, J; Peng, Y; Wei, H; Wu, Z, 2012) |
| "Many cases of early-onset inherited Alzheimer's disease (AD) are caused by mutations in the presenilin-1 (PS1) gene." | 1.31 | Presenilin-1 mutation increases neuronal vulnerability to focal ischemia in vivo and to hypoxia and glucose deprivation in cell culture: involvement of perturbed calcium homeostasis. ( Kindy, MS; Mattson, MP; Yu, J; Zhu, H, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (7.14) | 18.7374 |
| 1990's | 1 (7.14) | 18.2507 |
| 2000's | 1 (7.14) | 29.6817 |
| 2010's | 5 (35.71) | 24.3611 |
| 2020's | 6 (42.86) | 2.80 |
| Authors | Studies |
|---|---|
| Jiang, B | 1 |
| Shi, Y | 4 |
| Abou, MB | 2 |
| Xu, L | 2 |
| Liang, G | 4 |
| Wei, H | 6 |
| Mustaly-Kalimi, S | 3 |
| Gallegos, W | 3 |
| Marr, RA | 3 |
| Gilman-Sachs, A | 3 |
| Peterson, DA | 3 |
| Sekler, I | 3 |
| Stutzmann, GE | 4 |
| Bolognino, I | 1 |
| Giangregorio, N | 1 |
| Pisani, L | 1 |
| de Candia, M | 1 |
| Purgatorio, R | 1 |
| Tonazzi, A | 1 |
| Altomare, CD | 1 |
| Cellamare, S | 1 |
| Catto, M | 1 |
| Wang, Y | 2 |
| Liang, S | 1 |
| Mund, R | 1 |
| Sun, L | 1 |
| Zhang, L | 1 |
| Gao, X | 1 |
| Zhang, J | 1 |
| Ben Abou, M | 1 |
| Meng, Q | 2 |
| Hepner, A | 1 |
| Eckenhoff, MF | 2 |
| Dai, B | 1 |
| Ma, X | 1 |
| Tang, Y | 1 |
| Guo, S | 1 |
| Chen, X | 1 |
| Lu, S | 1 |
| Wang, G | 1 |
| Liu, Y | 1 |
| Peng, J | 1 |
| Inan, S | 1 |
| Wu, Z | 1 |
| Joseph, DJ | 1 |
| Peng, Y | 1 |
| Oulès, B | 1 |
| Del Prete, D | 1 |
| Greco, B | 1 |
| Zhang, X | 1 |
| Lauritzen, I | 1 |
| Sevalle, J | 1 |
| Moreno, S | 1 |
| Paterlini-Bréchot, P | 1 |
| Trebak, M | 1 |
| Checler, F | 1 |
| Benfenati, F | 1 |
| Chami, M | 1 |
| Chakroborty, S | 1 |
| Briggs, C | 1 |
| Miller, MB | 1 |
| Goussakov, I | 1 |
| Schneider, C | 1 |
| Kim, J | 1 |
| Wicks, J | 1 |
| Richardson, JC | 1 |
| Conklin, V | 1 |
| Cameransi, BG | 1 |
| Guo, Q | 1 |
| Sopher, BL | 1 |
| Furukawa, K | 1 |
| Pham, DG | 1 |
| Robinson, N | 1 |
| Martin, GM | 1 |
| Mattson, MP | 2 |
| Zhu, H | 1 |
| Yu, J | 1 |
| Kindy, MS | 1 |
| Rosse, R | 1 |
| Ciolino, C | 1 |
2 reviews available for dantrolene and Acute Confusional Senile Dementia
| Article | Year |
|---|---|
Approaches to Optimizing Dantrolene Neuroprotection for the Treatment of Alzheimer's Disease.
Topics: Alzheimer Disease; Animals; Calcium Channel Blockers; Calcium Signaling; Dantrolene; Humans; Neuropr | 2020 |
Dantrolene : From Malignant Hyperthermia to Alzheimer's Disease.
Topics: Alzheimer Disease; Animals; Calcium; Dantrolene; Humans; Malignant Hyperthermia; Muscle, Skeletal; R | 2019 |
12 other studies available for dantrolene and Acute Confusional Senile Dementia
| Article | Year |
|---|---|
Effects of chronic intranasal dantrolene on nasal mucosa morphology in mice.
Topics: Administration, Intranasal; Alzheimer Disease; Animals; Dantrolene; Mice; Nasal Mucosa; Olfactory Mu | 2022 |
Protein mishandling and impaired lysosomal proteolysis generated through calcium dysregulation in Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Calcium; Calcium, Dietary; Dantrolene; Disease Models, Animal; Humans; L | 2022 |
Protein mishandling and impaired lysosomal proteolysis generated through calcium dysregulation in Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Calcium; Calcium, Dietary; Dantrolene; Disease Models, Animal; Humans; L | 2022 |
Protein mishandling and impaired lysosomal proteolysis generated through calcium dysregulation in Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Calcium; Calcium, Dietary; Dantrolene; Disease Models, Animal; Humans; L | 2022 |
Protein mishandling and impaired lysosomal proteolysis generated through calcium dysregulation in Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Calcium; Calcium, Dietary; Dantrolene; Disease Models, Animal; Humans; L | 2022 |
A Prospective Repurposing of Dantrolene as a Multitarget Agent for Alzheimer's Disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Calcium; Calcium Channel Blockers; Carnitine; Cell Line; Ch | 2019 |
Dantrolene Ameliorates Impaired Neurogenesis and Synaptogenesis in Induced Pluripotent Stem Cell Lines Derived from Patients with Alzheimer's Disease.
Topics: Adult; Alzheimer Disease; Cells, Cultured; Dantrolene; Humans; Induced Pluripotent Stem Cells; Male; | 2020 |
Intranasal Dantrolene as a Disease-Modifying Drug in Alzheimer 5XFAD Mice.
Topics: Administration, Intranasal; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Brain; Dantr | 2020 |
Design, synthesis, and biological activity of novel semicarbazones as potent Ryanodine receptor1 inhibitors of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Calcium Channel Blockers; Calcium Signaling; Dantrolene; Disease Models, | 2021 |
Dantrolene ameliorates cognitive decline and neuropathology in Alzheimer triple transgenic mice.
Topics: Alzheimer Disease; Animals; Blotting, Western; Cognition Disorders; Dantrolene; Disease Models, Anim | 2012 |
Ryanodine receptor blockade reduces amyloid-β load and memory impairments in Tg2576 mouse model of Alzheimer disease.
Topics: Alzheimer Disease; Aminophenols; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Prec | 2012 |
Stabilizing ER Ca2+ channel function as an early preventative strategy for Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Calcium; Calcium Signaling; Dantrolene; Disease M | 2012 |
Alzheimer's presenilin mutation sensitizes neural cells to apoptosis induced by trophic factor withdrawal and amyloid beta-peptide: involvement of calcium and oxyradicals.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Apoptosis; Blood Proteins; Calcium; | 1997 |
Presenilin-1 mutation increases neuronal vulnerability to focal ischemia in vivo and to hypoxia and glucose deprivation in cell culture: involvement of perturbed calcium homeostasis.
Topics: Alzheimer Disease; Animals; Apoptosis; Blood Pressure; Calcium; Carbon Dioxide; Cell Hypoxia; Cells, | 2000 |
Dopamine agonists and neuroleptic malignant syndrome.
Topics: Alzheimer Disease; Amantadine; Basal Ganglia Diseases; Bromocriptine; Dantrolene; Humans; Male; Midd | 1985 |