dantrolene and Acid beta-Glucosidase Deficiency studies

Dantrolene: Skeletal muscle relaxant that acts by interfering with excitation-contraction coupling in the muscle fiber. It is used in spasticity and other neuromuscular abnormalities. Although the mechanism of action is probably not central, dantrolene is usually grouped with the central muscle relaxants.
dantrolene : The hydrazone resulting from the formal condensation of 5-(4-nitrophenyl)furfural with 1-aminohydantoin. A ryanodine receptor antagonist used for the relief of chronic severe spasticity and malignant hyperthermia.

Research Excerpts

Excerpt	Relevance	Reference
"Dantrolene treatment partially normalized Ryr expression and its potential regulators, CAMK IV and calmodulin."	5.43	Modulating ryanodine receptors with dantrolene attenuates neuronopathic phenotype in Gaucher disease mice. ( Blackwood, R; Dasgupta, N; Fleming, S; Grabowski, GA; Inskeep, V; Li, R; Liou, B; Marshall, J; Peng, Y; Quinn, B; Setchell, KD; Sun, Y; Zhang, W, 2016)
"Dantrolene treatment partially normalized Ryr expression and its potential regulators, CAMK IV and calmodulin."	1.43	Modulating ryanodine receptors with dantrolene attenuates neuronopathic phenotype in Gaucher disease mice. ( Blackwood, R; Dasgupta, N; Fleming, S; Grabowski, GA; Inskeep, V; Li, R; Liou, B; Marshall, J; Peng, Y; Quinn, B; Setchell, KD; Sun, Y; Zhang, W, 2016)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	1 (100.00)	24.3611
2020's	0 (0.00)	2.80

dantrolene and Acid beta-Glucosidase Deficiency

Research Excerpts

Research

Studies (1)

Authors

Other Studies

Authors	Studies
Liou, B	1
Peng, Y	1
Li, R	1
Inskeep, V	1
Zhang, W	1
Quinn, B	1
Dasgupta, N	1
Blackwood, R	1
Setchell, KD	1
Fleming, S	1
Grabowski, GA	1
Marshall, J	1
Sun, Y	1