dan 2163 and Dyskinesia, Medication-Induced studies

Research Excerpts

Excerpt	Relevance	Reference
" In this long-term, open, randomised, multicentre trial, patients with chronic or subchronic schizophrenia received amisulpride (n =370) or haloperidol (n = 118) for 12 months."	5.09	Long-term safety and efficacy of amisulpride in subchronic or chronic schizophrenia. Amisulpride Study Group. ( Colonna, L; Dondey-Nouvel, L; Rein, W; Saleem, P, 2000)
"Following ten years of continuous olanzapine therapy a 51 years old man developed a Gilles de la Tourette syndrome which disappeared after changing to amisulprid."	3.74	[Gilles-de-la-Tourette Syndrome as a Tardive Dyskinesia]. ( Friederich, M; Kozian, R, 2007)
" Extrapyramidal tolerability was better in the ASP group, as demonstrated by smaller increases in the Simpson-Angus Scale, the AIMS, and the Barnes Akathisia Scale in ANCOVA analyses with dosage as covariate."	2.69	Amisulpride versus flupentixol in schizophrenia with predominantly positive symptomatology -- a double-blind controlled study comparing a selective D2-like antagonist to a mixed D1-/D2-like antagonist. The Amisulpride Study Group. ( Adler, G; Benkert, O; Gattaz, WF; Gründer, G; Hillert, A; Philipp, M; Rein, W; Sauer, H; Schröder, J; Wetzel, H, 1998)
"Risperidone appears to be an effective therapy, but several authors report cases of TD during treatment."	2.41	Tardive dyskinesias and antipsychotics: a review. ( Bayle, FJ; Chereau, I; Lancon, C; Llorca, PM, 2002)
"Although schizophrenia affects all age groups, late or very-late-onset schizophrenia-like psychosis has not been well studied and various treatment issues remain unresolved."	1.35	Amisulpride for the treatment of very-late-onset schizophrenia-like psychosis. ( Papadimitriou, GN; Paparrigopoulos, TJ; Politis, AM; Psarros, C; Theleritis, CG, 2009)
"Aripiprazole is a new generation antipsychotic drug with a partial agonist effect on dopamine D2 and D3 receptors."	1.35	Aripiprazole in combination with other antipsychotic drugs may worsen psychosis. ( Adan-Manes, J; Garcia-Parajua, P, 2009)

Research

Studies (29)

Authors

Clinical Trials (1)

Trial Overview

Trial Outcomes

Change in Abdominal Fat (DEXA).

Timeframe	Studies, this research(%)	All Research%
pre-1990	2 (6.90)	18.7374
1990's	3 (10.34)	18.2507
2000's	17 (58.62)	29.6817
2010's	7 (24.14)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Erguner Aral, A	1
Ozberk, B	1
Sarisoy, G	1
Sevincok, L	1
Balci, V	1
Akyildiz, U	1
Psarros, C	1
Theleritis, CG	1
Paparrigopoulos, TJ	1
Politis, AM	1
Papadimitriou, GN	1
Adan-Manes, J	1
Garcia-Parajua, P	1
Mendhekar, DN	3
Andrade, C	2
Rizos, E	1
Douzenis, A	1
Gournellis, R	1
Christodoulou, C	1
Lykouras, LP	1
Guriz, O	1
Ekinci, AE	1
Orsel, S	1
Ekinci, O	1
Goyal, N	1
Sinha, VK	1
Chen, CC	1
Chen, YY	1
Hung, GC	1
Lee, SJ	1
Lee, JH	1
Jung, SW	1
Koo, BH	1
Choi, TY	1
Lee, KH	1
Correll, CU	1
Leucht, S	1
Kane, JM	1
Müller, JL	1
Putzhammer, A	1
Hajak, G	1
Müller, MJ	1
Regenbogen, B	1
Härtter, S	1
Eich, FX	2
Hiemke, C	1
Fountoulakis, KN	1
Panagiotidis, P	1
Siamouli, M	1
Kantartzis, S	1
Mavridis, T	1
Iacovides, A	1
Kaprinis, G	1
Limosin, F	1
Linden, M	1
Pyrkosch, L	1
Kozian, R	1
Friederich, M	1
Leclere, A	1
Plichart, P	1
Freeman, HL	1
Wetzel, H	1
Gründer, G	1
Hillert, A	1
Philipp, M	1
Gattaz, WF	1
Sauer, H	1
Adler, G	1
Schröder, J	1
Rein, W	2
Benkert, O	1
Colonna, L	1
Saleem, P	1
Dondey-Nouvel, L	1
Naber, D	1
Möller, HJ	1
Marchese, G	1
Casu, MA	1
Bartholini, F	1
Ruiu, S	1
Saba, P	1
Gessa, GL	1
Pani, L	1
Llorca, PM	1
Chereau, I	1
Bayle, FJ	1
Lancon, C	1
Boyer, P	1
Lecrubier, Y	1
Puech, AJ	1
Amore, M	1
Cerisoli, M	1
Campanile, S	1
Campanile, A	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Phase IV Study of Ramelteon as an Adjunct Therapy in Non-Diabetic Patients With Schizophrenia[NCT00595504]	Phase 4	25 participants (Actual)	Interventional	2008-01-31	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

A comparison between the ramelteon group and the placebo group of change in abdominal fat measured by a DEXA scan, assessed at Baseline and Week 8. (NCT00595504)
Timeframe: Baseline and Week 8

Change in Insulin Resistance as Measured by the Homeostatic Model Assessment of Insulin Resistance (HOMA-IR).

Intervention	g (Mean)
Ramelteon	3934.86
Placebo (Sugar Pill)	5120.92

A comparison between the ramelteon group and the placebo group of change in insulin resistance measured by the homeostatic model assessment of insulin resistance (HOMA-IR), assessed at Baseline and Week 8. (NCT00595504)
Timeframe: Baseline and Week 8

Change in Waist Circumference

Intervention	HOMA score (Mean)
Ramelteon	2.4
Placebo (Sugar Pill)	2.36

A comparison between the ramelteon group and the placebo group in change in waist circumference (measured in cm) measured at Baseline and Week 8. (NCT00595504)
Timeframe: Baseline and Week 8

Article	Year
Lower risk for tardive dyskinesia associated with second-generation antipsychotics: a systematic review of 1-year studies. The American journal of psychiatry, 2004, Volume: 161, Issue:3 Topics: Adolescent; Adult; Aged; Amisulpride; Antipsychotic Agents; Benzodiazepines; Child; Dibenzothiazepin	2004
[The use of atypical antipsychotics in the long-term care of schizophrenia]. L'Encephale, 2006, Volume: 32 Pt 3 Topics: Amisulpride; Antipsychotic Agents; Aripiprazole; Basal Ganglia Diseases; Benzodiazepines; Clozapine;	2006
Amisulpride compared with standard neuroleptics in acute exacerbations of schizophrenia: three efficacy studies. International clinical psychopharmacology, 1997, Volume: 12 Suppl 2 Topics: Adult; Amisulpride; Antipsychotic Agents; Chronic Disease; Dose-Response Relationship, Drug; Double-	1997
[New i.e. atypical neuroleptic agents for negative symptoms of schizophrenia: results and methodological problems of evaluation]. Der Nervenarzt, 2000, Volume: 71, Issue:5 Topics: Amisulpride; Antipsychotic Agents; Benzodiazepines; Clozapine; Dibenzothiazepines; Dibenzothiepins;	2000
Tardive dyskinesias and antipsychotics: a review. European psychiatry : the journal of the Association of European Psychiatrists, 2002, Volume: 17, Issue:3 Topics: Amisulpride; Antipsychotic Agents; Benzodiazepines; Clozapine; Dyskinesia, Drug-Induced; Humans; Ola	2002

Article	Year
A 6-week, randomized, multicentre, open-label study comparing efficacy and tolerability of amisulpride at a starting dose of 400 mg/day versus 800 mg/day in patients with acute exacerbations of schizophrenia. Clinical drug investigation, 2012, Volume: 32, Issue:11 Topics: Adult; Aged; Amisulpride; Analysis of Variance; Antipsychotic Agents; Chi-Square Distribution; Disea	2012
Amisulpride versus flupentixol in schizophrenia with predominantly positive symptomatology -- a double-blind controlled study comparing a selective D2-like antagonist to a mixed D1-/D2-like antagonist. The Amisulpride Study Group. Psychopharmacology, 1998, Volume: 137, Issue:3 Topics: Adult; Amisulpride; Antipsychotic Agents; Dopamine Antagonists; Double-Blind Method; Dyskinesia, Dru	1998
Long-term safety and efficacy of amisulpride in subchronic or chronic schizophrenia. Amisulpride Study Group. International clinical psychopharmacology, 2000, Volume: 15, Issue:1 Topics: Adolescent; Adult; Aged; Amisulpride; Antipsychotic Agents; Chronic Disease; Dyskinesia, Drug-Induce	2000
Treatment of positive and negative symptoms: pharmacologic approaches. Modern problems of pharmacopsychiatry, 1990, Volume: 24 Topics: Adult; Amisulpride; Antipsychotic Agents; Clinical Trials as Topic; Dose-Response Relationship, Drug	1990

Article	Year
Rabbit syndrome as a side effect triggered by amisulpride. Asia-Pacific psychiatry : official journal of the Pacific Rim College of Psychiatrists, 2019, Volume: 11, Issue:1 Topics: Amisulpride; Antipsychotic Agents; Dyskinesia, Drug-Induced; Facial Muscles; Female; Humans; Jaw; Li	2019
Tardive dystonia associated with low-dose of amisulpride: a case report. Journal of clinical psychopharmacology, 2008, Volume: 28, Issue:5 Topics: Adult; Amisulpride; Antipsychotic Agents; Clozapine; Dyskinesia, Drug-Induced; Dystonia; Humans; Mal	2008
Amisulpride for the treatment of very-late-onset schizophrenia-like psychosis. International journal of geriatric psychiatry, 2009, Volume: 24, Issue:5 Topics: Age of Onset; Aged; Aged, 80 and over; Amisulpride; Antipsychotic Agents; Dyskinesia, Drug-Induced;	2009
Aripiprazole in combination with other antipsychotic drugs may worsen psychosis. Journal of clinical pharmacy and therapeutics, 2009, Volume: 34, Issue:2 Topics: Amisulpride; Anti-Dyskinesia Agents; Antipsychotic Agents; Aripiprazole; Biperiden; Dopamine; Drug T	2009
Amisulpride-induced tardive dyskinesia and possible association of dyskinesia with hypothyroidism. The Journal of neuropsychiatry and clinical neurosciences, 2009,Winter, Volume: 21, Issue:1 Topics: Amisulpride; Dopamine Antagonists; Dyskinesia, Drug-Induced; Humans; Hypothyroidism; Male; Sulpiride	2009
Tardive dyskinesia in a patient treated with quetiapine. The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry, 2009, Volume: 10, Issue:1 Topics: Amisulpride; Antipsychotic Agents; Aripiprazole; Basal Ganglia Diseases; Dibenzothiazepines; Dyskine	2009
Amisulpride-induced tardive dystonia: a case report. Progress in neuro-psychopharmacology & biological psychiatry, 2010, Mar-17, Volume: 34, Issue:2 Topics: Adult; Amisulpride; Antipsychotic Agents; Dyskinesia, Drug-Induced; Dystonia; Electroencephalography	2010
Amisulpride-induced tardive dyskinesia in childhood onset schizophrenia. Progress in neuro-psychopharmacology & biological psychiatry, 2010, May-30, Volume: 34, Issue:4 Topics: Adolescent; Amisulpride; Antipsychotic Agents; Dyskinesia, Drug-Induced; Humans; Male; Schizophrenia	2010
Tardive dystonia induced by switch of atypical antipsychotics. Pharmacopsychiatry, 2010, Volume: 43, Issue:5 Topics: Amisulpride; Antipsychotic Agents; Benzodiazepines; Clozapine; Dyskinesia, Drug-Induced; Female; Hum	2010
Possible rabbit syndrome with amisulpride. The Journal of neuropsychiatry and clinical neurosciences, 2010,Summer, Volume: 22, Issue:3 Topics: Aged; Amisulpride; Dyskinesia, Drug-Induced; Humans; Male; Sulpiride	2010
Amisulpride may worsen dyskinesia and trigger new-onset dyskinetic movements. The Journal of neuropsychiatry and clinical neurosciences, 2010,Summer, Volume: 22, Issue:3 Topics: Aged; Amisulpride; Antipsychotic Agents; Dyskinesia, Drug-Induced; Female; Humans; Schizophrenia; Su	2010
[Functional magnetic resonance tomography of central motor areas in schizophrenic patients]. Psychiatrische Praxis, 2005, Volume: 32 Suppl 1 Topics: Amisulpride; Antipsychotic Agents; Biomechanical Phenomena; Dyskinesia, Drug-Induced; Gait Apraxia;	2005
Therapeutic drug monitoring for optimizing amisulpride therapy in patients with schizophrenia. Journal of psychiatric research, 2007, Volume: 41, Issue:8 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amisulpride; Antipsychotic Agents; Dose-Response Relatio	2007
Amisulpride-induced tardive dyskinesia. Schizophrenia research, 2006, Volume: 88, Issue:1-3 Topics: Adult; Amisulpride; Antipsychotic Agents; Diagnostic and Statistical Manual of Mental Disorders; Dru	2006
Do differences in atypical antipsychotics matter in routine practice? Medication switch from olanzapine and risperidone to amisulpride. International clinical psychopharmacology, 2007, Volume: 22, Issue:3 Topics: Adolescent; Adult; Amisulpride; Antipsychotic Agents; Benzodiazepines; Drug Utilization; Dyskinesia,	2007
[Gilles-de-la-Tourette Syndrome as a Tardive Dyskinesia]. Psychiatrische Praxis, 2007, Volume: 34, Issue:5 Topics: Amisulpride; Antipsychotic Agents; Benzodiazepines; Drug Therapy, Combination; Dyskinesia, Drug-Indu	2007
[Use of sultopride in a case of neuroleptic-induced late dyskinesia]. La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris, 1982, Nov-18, Volume: 58, Issue:42 Topics: Amisulpride; Antipsychotic Agents; Dyskinesia, Drug-Induced; Female; Humans; Middle Aged; Sulpiride	1982
[Atypical antipsychotics]. Der Nervenarzt, 2000, Volume: 71, Issue:5 Topics: Acute Disease; Amisulpride; Antipsychotic Agents; Benzodiazepines; Clozapine; Cost-Benefit Analysis;	2000
Sub-chronic treatment with classical but not atypical antipsychotics produces morphological changes in rat nigro-striatal dopaminergic neurons directly related to "early onset" vacuous chewing. The European journal of neuroscience, 2002, Volume: 15, Issue:7 Topics: Amisulpride; Animals; Antipsychotic Agents; Clozapine; Dopamine; Dose-Response Relationship, Drug; D	2002
Pisa syndrome. Report of a case. Italian journal of neurological sciences, 1988, Volume: 9, Issue:3 Topics: Adult; Amisulpride; Antipsychotic Agents; Dyskinesia, Drug-Induced; Haloperidol; Humans; Male; Schiz	1988

dan 2163 and Dyskinesia, Medication-Induced