dan 2163 has been researched along with Bipolar Disorder in 18 studies
Bipolar Disorder: A major affective disorder marked by severe mood swings (manic or major depressive episodes) and a tendency to remission and recurrence.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Randomised trials comparing haloperidol with placebo or other active treatment in the treatment of acute manic or mixed episodes in patients with bipolar disorder or schizoaffective disorder." | 4.83 | Haloperidol alone or in combination for acute mania. ( Cipriani, A; Geddes, JR; Rendell, JM, 2006) |
| "A 19-year-old man with schizophrenia and underlying cerebral disease developed rapid-onset mania after risperidone was replaced with amisulpride." | 3.80 | Amisulpride-associated mania in a young adult with schizophrenia and cerebral disease. ( Chen, CY; Chen, TY; Chuang, WC; Kuo, SC; Yeh, YW, 2014) |
| "Clozapine had a significantly lower discontinuation rate in individuals with schizophrenia, compared to the other 4 SGAs." | 3.74 | Comparing the use and discontinuation of antipsychotics in clinical practice: an observational study. ( Lawrie, SM; Shajahan, P; Taylor, M, 2008) |
| " SEP-4199 had low rates of individual adverse events (<8%) and minimal effects on weight and lipids; median increases in prolactin were +83." | 3.11 | A Randomized, Double-blind, Placebo-controlled Proof-of-Concept Trial to Evaluate the Efficacy and Safety of Non-racemic Amisulpride (SEP-4199) for the Treatment of Bipolar I Depression. ( Deng, L; Fava, M; Hopkins, SC; Kent, J; Koblan, KS; Loebel, A; Tsai, J, 2022) |
| "This does not extend to bipolar depression, however, good data is now emerging for some agents and will need to be considered for each individual agent as it accumulates." | 2.43 | A typical mood stabilizers: a "typical role for atypical antipsychotics. ( Berk, M; Bourin, M; Dodd, S; Ivanovski, B; Lagopoulos, J; Malhi, GS; Mitchell, PB, 2005) |
| "Risperidone monotherapy treatment was associated with hyperprolactinaemia in 69% of patients ( n = 35) and in 100% of female patients (n = 16) and amisulpride monotherapy in 100% (n = 7)." | 1.34 | Prevalence of hyperprolactinaemia in a naturalistic cohort of schizophrenia and bipolar outpatients during treatment with typical and atypical antipsychotics. ( Bushe, C; Shaw, M, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (11.11) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 9 (50.00) | 29.6817 |
| 2010's | 5 (27.78) | 24.3611 |
| 2020's | 2 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Loebel, A | 2 |
| Koblan, KS | 2 |
| Tsai, J | 1 |
| Deng, L | 1 |
| Fava, M | 1 |
| Kent, J | 1 |
| Hopkins, SC | 2 |
| Wilkinson, S | 1 |
| Corriveau, TJ | 1 |
| Nishikawa, H | 1 |
| Nakamichi, K | 1 |
| Hou, YC | 1 |
| Lai, CH | 1 |
| Chuang, WC | 1 |
| Chen, CY | 1 |
| Kuo, SC | 1 |
| Chen, TY | 2 |
| Yeh, YW | 1 |
| Hong, CC | 1 |
| Chen, CK | 1 |
| Yeh, TC | 1 |
| Chu, CS | 1 |
| Bakhla, AK | 1 |
| Goyal, N | 1 |
| Nizamie, SH | 1 |
| Yasugi, S | 1 |
| Garg, V | 1 |
| Been, G | 1 |
| Magoulas, P | 1 |
| Teoh, S | 1 |
| Ilett, KF | 1 |
| Hackett, LP | 1 |
| Kohan, R | 1 |
| Murphy, BP | 1 |
| Vieta, E | 1 |
| Ros, S | 1 |
| Goikolea, JM | 1 |
| Benabarre, A | 1 |
| Popova, E | 1 |
| Comes, M | 1 |
| Capapey, J | 1 |
| Sánchez-Moreno, J | 1 |
| Malhi, GS | 1 |
| Berk, M | 1 |
| Bourin, M | 1 |
| Ivanovski, B | 1 |
| Dodd, S | 1 |
| Lagopoulos, J | 1 |
| Mitchell, PB | 1 |
| Cipriani, A | 1 |
| Rendell, JM | 1 |
| Geddes, JR | 1 |
| Bushe, C | 1 |
| Shaw, M | 1 |
| Bret, MC | 1 |
| Bret, P | 1 |
| Pariente, A | 1 |
| Fourier-Réglat, A | 1 |
| Abay, E | 1 |
| Kose, R | 1 |
| Taylor, M | 1 |
| Shajahan, P | 1 |
| Lawrie, SM | 1 |
| Lang, F | 1 |
| Berger, M | 1 |
| Tamet, JY | 1 |
| Richou, H | 1 |
| Hug, R | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study of SEP-4199 for the Treatment of Major Depressive Episode Associated With Bipolar I Disorder (Bipolar I Depression)[NCT03543410] | Phase 2 | 344 participants (Actual) | Interventional | 2018-06-26 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Clinical Global Impressions - Severity: Bipolar Version (CGI-BP-S) score (depression) is a single value, clinician-rated assessment of illness severity, and 7-point scale with range from 1 = normal, not at all ill; 2 = borderline mentally ill; 3 = mildly ill; 4 = moderately ill; 5 = markedly ill; 6 = severely ill; 7 = among the most extremely ill subjects. A higher score is associated with greater illness severity. (NCT03543410)
Timeframe: 6 Weeks
| Intervention | units on a scale (Least Squares Mean) |
|---|---|
| SEP-4199 200 mg | -2.020 |
| SEP-4199 400 mg | -1.958 |
| Placebo | -1.739 |
MADRS is a clinician-rated assessment of the subject's level of depression. The measure contains 10 items that measure apparent and reported sadness, inner tension, reduced sleep and appetite, difficulty concentrating, lassitude, inability to feel, and pessimistic and suicidal thoughts, each ranging from 0 to 6. The MADRS total score ranges from 0 to 60, with higher scores indicating increased depressive symptoms (NCT03543410)
Timeframe: 6 Weeks
| Intervention | units on a scale (Least Squares Mean) |
|---|---|
| SEP-4199 200 mg | -19.485 |
| SEP-4199 400 mg | -19.324 |
| Placebo | -16.196 |
2 reviews available for dan 2163 and Bipolar Disorder
| Article | Year |
|---|---|
A typical mood stabilizers: a "typical role for atypical antipsychotics.
Topics: Affect; Amisulpride; Antipsychotic Agents; Aripiprazole; Benzodiazepines; Bipolar Disorder; Clozapin | 2005 |
Haloperidol alone or in combination for acute mania.
Topics: Amisulpride; Antipsychotic Agents; Aripiprazole; Benzodiazepines; Bipolar Disorder; Carbamazepine; D | 2006 |
3 trials available for dan 2163 and Bipolar Disorder
| Article | Year |
|---|---|
A Randomized, Double-blind, Placebo-controlled Proof-of-Concept Trial to Evaluate the Efficacy and Safety of Non-racemic Amisulpride (SEP-4199) for the Treatment of Bipolar I Depression.
Topics: Amisulpride; Bipolar Disorder; Depression; Diagnostic and Statistical Manual of Mental Disorders; Do | 2022 |
Discovery of Nonracemic Amisulpride to Maximize Benefit/Risk of 5-HT7 and D2 Receptor Antagonism for the Treatment of Mood Disorders.
Topics: Adult; Amisulpride; Animals; Antidepressive Agents; Antipsychotic Agents; Bipolar Disorder; Dopamine | 2021 |
An open-label study of amisulpride in the treatment of mania.
Topics: Adult; Amisulpride; Antipsychotic Agents; Bipolar Disorder; Drug Administration Schedule; Drug Thera | 2005 |
13 other studies available for dan 2163 and Bipolar Disorder
| Article | Year |
|---|---|
The effectiveness of high-dosage amisulpride combined with moderate-dosage sodium valproate treatment for an overweight patient with psychotic bipolar disorder.
Topics: Amisulpride; Antimanic Agents; Antipsychotic Agents; Bipolar Disorder; Drug Therapy, Combination; Fe | 2014 |
Amisulpride-associated mania in a young adult with schizophrenia and cerebral disease.
Topics: Amisulpride; Antipsychotic Agents; Bipolar Disorder; Cerebral Palsy; Drug Administration Schedule; H | 2014 |
Amisulpride monotherapy may be a choice of maintenance treatment for patients with both bipolar I disorder and metabolic syndrome.
Topics: Amisulpride; Antipsychotic Agents; Bipolar Disorder; Humans; Male; Metabolic Syndrome; Sulpiride; Yo | 2015 |
Amisulpride-induced mania with interictal psychosis.
Topics: Adolescent; Amisulpride; Antipsychotic Agents; Bipolar Disorder; Humans; Male; Psychotic Disorders; | 2009 |
Neuroleptic malignant syndrome.
Topics: Adult; Amisulpride; Antimanic Agents; Antipsychotic Agents; Bipolar Disorder; Dose-Response Relation | 2010 |
Estimation of rac-amisulpride transfer into milk and of infant dose via milk during its use in a lactating woman with bipolar disorder and schizophrenia.
Topics: Adult; Amisulpride; Antipsychotic Agents; Bipolar Disorder; Breast Feeding; Child Development; Chrom | 2011 |
Amisulpride-induced mania in a patient with schizophrenia.
Topics: Adolescent; Amisulpride; Antipsychotic Agents; Bipolar Disorder; Female; Humans; Schizophrenia; Sulp | 2003 |
Prevalence of hyperprolactinaemia in a naturalistic cohort of schizophrenia and bipolar outpatients during treatment with typical and atypical antipsychotics.
Topics: Adult; Amisulpride; Antipsychotic Agents; Bipolar Disorder; Cohort Studies; Cross-Sectional Studies; | 2007 |
The use of atypical antipsychotics in French psychiatric hospitals.
Topics: Adult; Age Factors; Amisulpride; Antimanic Agents; Antiparkinson Agents; Antipsychotic Agents; Benzo | 2007 |
Amisulpride-induced neuroleptic malignant syndrome.
Topics: Aged; Amisulpride; Antipsychotic Agents; Bipolar Disorder; Creatine Kinase; Humans; Male; Neurolepti | 2007 |
Comparing the use and discontinuation of antipsychotics in clinical practice: an observational study.
Topics: Adult; Aged; Amisulpride; Antipsychotic Agents; Benzodiazepines; Bipolar Disorder; Clozapine; Dibenz | 2008 |
[Sultopride treatment of a chronic psychotic child with predominantly maniacal manifestations].
Topics: Affective Disorders, Psychotic; Amisulpride; Bipolar Disorder; Child; Female; Humans; Psychotropic D | 1982 |
[Sultopride in a day hospital].
Topics: Amisulpride; Bipolar Disorder; Day Care, Medical; Hospitals, Psychiatric; Humans; Male; Mental Disor | 1979 |