Page last updated: 2024-10-18

dalteparin and Osteoporosis

dalteparin has been researched along with Osteoporosis in 9 studies

Dalteparin: A low-molecular-weight fragment of heparin, prepared by nitrous acid depolymerization of porcine mucosal heparin. The mean molecular weight is 4000-6000 daltons. It is used therapeutically as an antithrombotic agent. (From Merck Index, 11th ed)

Osteoporosis: Reduction of bone mass without alteration in the composition of bone, leading to fractures. Primary osteoporosis can be of two major types: postmenopausal osteoporosis (OSTEOPOROSIS, POSTMENOPAUSAL) and age-related or senile osteoporosis.

Research Excerpts

ExcerptRelevanceReference
"We sought to determine whether long-term prophylactic dalteparin in pregnancy leads to loss of BMD."9.12Long-term dalteparin in pregnancy not associated with a decrease in bone mineral density: substudy of a randomized controlled trial. ( Clement, AM; Cranney, A; Hague, WM; Hodsman, A; Kahn, SR; Kovacs, MJ; Lazo-Langner, A; Rodger, MA, 2007)
"Objective This study was performed to evaluate the efficacy of rivaroxaban versus nadroparin for preventing deep venous thrombosis (DVT) in elderly patients with osteoporosis undergoing initial total hip arthroplasty (THA) for femoral neck fractures."7.88Rivaroxaban versus nadroparin for preventing deep venous thrombosis after total hip arthroplasty following femoral neck fractures: A retrospective comparative study. ( Chen, D; Ge, Z; Liang, G; Wan, Z; Xu, B; Yang, C; Yu, W; Zeng, X; Zhang, C; Zhang, F; Zhang, X, 2018)
"We sought to determine whether long-term prophylactic dalteparin in pregnancy leads to loss of BMD."5.12Long-term dalteparin in pregnancy not associated with a decrease in bone mineral density: substudy of a randomized controlled trial. ( Clement, AM; Cranney, A; Hague, WM; Hodsman, A; Kahn, SR; Kovacs, MJ; Lazo-Langner, A; Rodger, MA, 2007)
" In a randomised open study, 44 pregnant women with confirmed previous or current thromboembolism were randomised to receive either low-molecular-weight heparin, dalteparin (N = 21) once daily subcutaneously or unfractionated sodium heparin (UF heparin, N = 23) twice daily subcutaneously for thromboprophylaxis during pregnancy and puerperium."5.10Postpartum bone mineral density in women treated for thromboprophylaxis with unfractionated heparin or LMW heparin. ( Hiilesmaa, V; Kaaja, R; Leinonen, P; Markkola, A; Pettilä, V, 2002)
"Objective This study was performed to evaluate the efficacy of rivaroxaban versus nadroparin for preventing deep venous thrombosis (DVT) in elderly patients with osteoporosis undergoing initial total hip arthroplasty (THA) for femoral neck fractures."3.88Rivaroxaban versus nadroparin for preventing deep venous thrombosis after total hip arthroplasty following femoral neck fractures: A retrospective comparative study. ( Chen, D; Ge, Z; Liang, G; Wan, Z; Xu, B; Yang, C; Yu, W; Zeng, X; Zhang, C; Zhang, F; Zhang, X, 2018)
"Fondaparinux did not inhibit osteoblast proliferation in vitro and may reduce the risk of heparin-induced osteoporosis associated with long-term heparin administration."3.73Effect of low molecular weight heparin (dalteparin) and fondaparinux (Arixtra) on human osteoblasts in vitro. ( Handschin, AE; Hoerstrup, SP; Kock, HJ; Trentz, O; Trentz, OA; Wanner, GA, 2005)
"Osteoporosis is a rare but potentially severe complication under high-dose, long-term unfractionated heparin therapy."1.31Osteoblast growth inhibition by unfractionated heparin and by low molecular weight heparins: an in-vitro investigation. ( Handschin, AE; Kock, HJ, 2002)

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (22.22)18.2507
2000's5 (55.56)29.6817
2010's2 (22.22)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Zhang, C1
Xu, B1
Liang, G1
Zeng, X1
Yang, C1
Zhang, F1
Wan, Z1
Yu, W1
Chen, D1
Ge, Z1
Zhang, X1
Kock, HJ2
Handschin, AE2
Martineau, P1
Tawil, N1
San Juan Alvarez, M1
Márquez Garrido, G1
Rodríguez Bertos, C1
González Pérez, L1
Gates, S1
Brocklehurst, P1
Ayers, S1
Bowler, U1
Trentz, OA1
Hoerstrup, SP1
Wanner, GA1
Trentz, O1
Rodger, MA1
Kahn, SR1
Cranney, A1
Hodsman, A1
Kovacs, MJ1
Clement, AM1
Lazo-Langner, A1
Hague, WM1
Shefras, J1
Farquharson, RG1
Pettilä, V1
Leinonen, P1
Markkola, A1
Hiilesmaa, V1
Kaaja, R1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Effects of UFH and LMWH on Osteoprotegerin and RANKL Plasma Levels in Hemodialysis Patients[NCT00669721]40 participants (Anticipated)Interventional2008-03-31Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for dalteparin and Osteoporosis

ArticleYear
Low-molecular-weight heparins in the treatment of deep-vein thrombosis.
    The Annals of pharmacotherapy, 1998, Volume: 32, Issue:5

    Topics: Blood Platelets; Capillary Permeability; Dalteparin; Enoxaparin; Fibrinolytic Agents; Hemorrhage; He

1998

Trials

3 trials available for dalteparin and Osteoporosis

ArticleYear
Thromboprophylaxis and pregnancy: two randomized controlled pilot trials that used low-molecular-weight heparin.
    American journal of obstetrics and gynecology, 2004, Volume: 191, Issue:4

    Topics: Adult; Cesarean Section; Enoxaparin; Female; Fibrinolytic Agents; Humans; Osteoporosis; Patient Sele

2004
Long-term dalteparin in pregnancy not associated with a decrease in bone mineral density: substudy of a randomized controlled trial.
    Journal of thrombosis and haemostasis : JTH, 2007, Volume: 5, Issue:8

    Topics: Adult; Anticoagulants; Bone Density; Bone Diseases, Metabolic; Dalteparin; Female; Humans; Middle Ag

2007
Postpartum bone mineral density in women treated for thromboprophylaxis with unfractionated heparin or LMW heparin.
    Thrombosis and haemostasis, 2002, Volume: 87, Issue:2

    Topics: Absorptiometry, Photon; Adult; Anticoagulants; Bone Density; Dalteparin; Factor Xa Inhibitors; Femal

2002

Other Studies

5 other studies available for dalteparin and Osteoporosis

ArticleYear
Rivaroxaban versus nadroparin for preventing deep venous thrombosis after total hip arthroplasty following femoral neck fractures: A retrospective comparative study.
    The Journal of international medical research, 2018, Volume: 46, Issue:5

    Topics: Aged; Arthroplasty, Replacement, Hip; Blood Coagulation; Demography; Female; Femoral Neck Fractures;

2018
Osteoblast growth inhibition by unfractionated heparin and by low molecular weight heparins: an in-vitro investigation.
    Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis, 2002, Volume: 8, Issue:3

    Topics: Adult; Anticoagulants; Cell Culture Techniques; Cell Division; Dalteparin; Enoxaparin; Heparin; Hepa

2002
[Hip fracture during pregancy in a woman with transient osteporosis].
    Revista espanola de anestesiologia y reanimacion, 2010, Volume: 57, Issue:5

    Topics: Accidental Falls; Adult; Anticoagulants; Bone Screws; Cesarean Section; Female; Fracture Fixation, I

2010
Effect of low molecular weight heparin (dalteparin) and fondaparinux (Arixtra) on human osteoblasts in vitro.
    The British journal of surgery, 2005, Volume: 92, Issue:2

    Topics: Alkaline Phosphatase; Anticoagulants; Cells, Cultured; Dalteparin; Fluoresceins; Fondaparinux; Gene

2005
Bone density studies in pregnant women receiving heparin.
    European journal of obstetrics, gynecology, and reproductive biology, 1996, Volume: 65, Issue:2

    Topics: Anticoagulants; Antiphospholipid Syndrome; Bone Density; Case-Control Studies; Dalteparin; Female; H

1996