Page last updated: 2024-10-18

dalteparin and Injuries, Leg

dalteparin has been researched along with Injuries, Leg in 16 studies

Dalteparin: A low-molecular-weight fragment of heparin, prepared by nitrous acid depolymerization of porcine mucosal heparin. The mean molecular weight is 4000-6000 daltons. It is used therapeutically as an antithrombotic agent. (From Merck Index, 11th ed)

Research Excerpts

ExcerptRelevanceReference
"The overall deep vein thrombosis (DVT) rate in group 1 was 3."1.31Dose-adjusted thrombosis prophylaxis in trauma surgery according to levels of D-Dimer. ( Hafner, G; Hansen, M; Mayer, A; Peetz, D; Prellwitz, W; Rippin, G; Rommens, PM, 2000)

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (12.50)18.2507
2000's9 (56.25)29.6817
2010's4 (25.00)24.3611
2020's1 (6.25)2.80

Authors

AuthorsStudies
Bruntink, MM1
Groutars, YME1
Schipper, IB1
Breederveld, RS1
Tuinebreijer, WE1
Derksen, RJ1
Haentjens, P1
Peetz, D1
Hafner, G1
Hansen, M1
Mayer, A1
Rippin, G1
Rommens, PM1
Prellwitz, W1
Mower, S1
Thompson, S1
Sems, SA1
Levy, BA1
Dajani, K1
Herrera, DA1
Templeman, DC1
Szczesny, G1
DeszczyƄski, J1
Lassen, MR1
Borris, LC1
Nakov, RL1
Doggrell, SA1
Jersmann, HP1
Murashige, N1
Kami, M1
Takaue, Y1
Girard, P1
Gehling, H1
Giannadakis, K1
Lefering, R1
Hessmann, M1
Achenbach, S1
Gotzen, L1
Menakaya, CU1
Pennington, N1
Muthukumar, N1
Joel, J1
Ramirez Jimenez, AJ1
Shaw, CJ1
Mohsen, A1
Selby, R1
Geerts, WH1
Kreder, HJ1
Crowther, MA1
Kaus, L1
Sealey, F1
Little, MT1
Goel, DP1
Buckley, R1
deVries, G1
Abelseth, G1
Ni, A1
Gray, R1

Clinical Trials (4)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Prophylaxis of Venous Thromboembolism in Patients With a Nonsurgical Fracture of the Lower Extremity Immobilised in a Below-Knee Plaster Cast[NCT00881088]Phase 2/Phase 3669 participants (Anticipated)Interventional2009-04-30Recruiting
A Different Approach to Preventing Thrombosis (ADAPT): A Randomized Controlled Trial Comparing Low Molecular Weight Heparin to Acetylsalicylic Acid in Orthopedic Trauma Patients[NCT02774265]Phase 3329 participants (Actual)Interventional2016-01-31Completed
Evaluation of the Prevention of Thromboembolic Disease in Patients With a Lower Limb Trauma, Non Surgical, in Winter Sports Resort.[NCT01303523]1,627 participants (Actual)Observational2010-12-31Completed
Clinically-Important Venous Thromboembolism Following Lower Extremity Fractures: Epidemiology & Prevention[NCT00187408]Phase 4700 participants Interventional2002-08-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Number of Participants With Deep Venous Thromboembolism

DVT and how the diagnosis was made will be recorded. The number of events in participants in each arm will be compared to evaluate efficacy. (NCT02774265)
Timeframe: 90 days

InterventionParticipants (Count of Participants)
VTE Prophylaxis With Enoxaparin 30mg BID5
VTE Prophylaxis With Aspirin 81mg BID9

Number of Participants With Pulmonary Embolism Events

Bases on imaging obtained for symptoms. (NCT02774265)
Timeframe: 90 days

InterventionParticipants (Count of Participants)
VTE Prophylaxis With Enoxaparin 30mg BID6
VTE Prophylaxis With Aspirin 81mg BID2

Number of Participants With Treatment-related Bleeding Events as Assessed by the Need for Blood Transfusions and Procedures for Bleeding Complications After Initiation of the Study Medication.

Includes a greater than 2g/dL drop in hemoglobin, blood transfusion, hematoma evacuation, re-operation for a deep surgical site infection or minor procedure for bleeding and GI bleed (NCT02774265)
Timeframe: 90 days

InterventionParticipants (Count of Participants)
VTE Prophylaxis With Enoxaparin 30mg BID52
VTE Prophylaxis With Aspirin 81mg BID53

Reviews

1 review available for dalteparin and Injuries, Leg

ArticleYear
Reviparin as prophylaxis for thromboembolism after leg injury and hip replacement.
    Expert opinion on pharmacotherapy, 2003, Volume: 4, Issue:2

    Topics: Administration, Oral; Anticoagulants; Arthroplasty, Replacement, Hip; Heparin, Low-Molecular-Weight;

2003

Trials

7 trials available for dalteparin and Injuries, Leg

ArticleYear
Nadroparin or fondaparinux versus no thromboprophylaxis in patients immobilised in a below-knee plaster cast (PROTECT): A randomised controlled trial.
    Injury, 2017, Volume: 48, Issue:4

    Topics: Adult; Anticoagulants; Casts, Surgical; Female; Fondaparinux; Humans; Immobilization; Leg Injuries;

2017
Thromboembolic prophylaxis in orthopaedic trauma patients: a comparison between a fixed dose and an individually adjusted dose of a low molecular weight heparin (nadroparin calcium)
    Injury, 1996, Volume: 27, Issue:6

    Topics: Aged; Anticoagulants; Drug Administration Schedule; Female; Hip Fractures; Humans; Leg Injuries; Mal

1996
[The frequency of peri- and postoperative bleeding after prophylactic treatment with enoxapirin in patients with post-traumatic deep vein thrombosis].
    Chirurgia narzadow ruchu i ortopedia polska, 2000, Volume: 65, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Anticoagulants; Blood Transfusion; Enoxaparin; Female; Humans; Leg I

2000
Use of the low-molecular-weight heparin reviparin to prevent deep-vein thrombosis after leg injury requiring immobilization.
    The New England journal of medicine, 2002, Sep-05, Volume: 347, Issue:10

    Topics: Achilles Tendon; Adult; Anticoagulants; Braces; Casts, Surgical; Double-Blind Method; Female; Fractu

2002
Use of the low-molecular-weight heparin reviparin to prevent deep-vein thrombosis after leg injury requiring immobilization.
    The New England journal of medicine, 2002, Sep-05, Volume: 347, Issue:10

    Topics: Achilles Tendon; Adult; Anticoagulants; Braces; Casts, Surgical; Double-Blind Method; Female; Fractu

2002
Use of the low-molecular-weight heparin reviparin to prevent deep-vein thrombosis after leg injury requiring immobilization.
    The New England journal of medicine, 2002, Sep-05, Volume: 347, Issue:10

    Topics: Achilles Tendon; Adult; Anticoagulants; Braces; Casts, Surgical; Double-Blind Method; Female; Fractu

2002
Use of the low-molecular-weight heparin reviparin to prevent deep-vein thrombosis after leg injury requiring immobilization.
    The New England journal of medicine, 2002, Sep-05, Volume: 347, Issue:10

    Topics: Achilles Tendon; Adult; Anticoagulants; Braces; Casts, Surgical; Double-Blind Method; Female; Fractu

2002
[Prospective randomized pilot study of ambulatory prevention of thromboembolism. 2 times 500 mg aspirin (ASS) vs. clivarin 1750 (NMH)].
    Der Unfallchirurg, 1998, Volume: 101, Issue:1

    Topics: Adult; Aged; Ambulatory Care; Anticoagulants; Aspirin; Casts, Surgical; Dose-Response Relationship,

1998
A double-blind, randomized controlled trial of the prevention of clinically important venous thromboembolism after isolated lower leg fractures.
    Journal of orthopaedic trauma, 2015, Volume: 29, Issue:5

    Topics: Adult; Aged; Ankle Fractures; Anticoagulants; Dalteparin; Double-Blind Method; Female; Fibula; Fract

2015
A double-blind, randomized controlled trial of the prevention of clinically important venous thromboembolism after isolated lower leg fractures.
    Journal of orthopaedic trauma, 2015, Volume: 29, Issue:5

    Topics: Adult; Aged; Ankle Fractures; Anticoagulants; Dalteparin; Double-Blind Method; Female; Fibula; Fract

2015
A double-blind, randomized controlled trial of the prevention of clinically important venous thromboembolism after isolated lower leg fractures.
    Journal of orthopaedic trauma, 2015, Volume: 29, Issue:5

    Topics: Adult; Aged; Ankle Fractures; Anticoagulants; Dalteparin; Double-Blind Method; Female; Fibula; Fract

2015
A double-blind, randomized controlled trial of the prevention of clinically important venous thromboembolism after isolated lower leg fractures.
    Journal of orthopaedic trauma, 2015, Volume: 29, Issue:5

    Topics: Adult; Aged; Ankle Fractures; Anticoagulants; Dalteparin; Double-Blind Method; Female; Fibula; Fract

2015
Prophylaxis of deep-vein thrombosis in fractures below the knee: a prospective randomised controlled trial.
    The Journal of bone and joint surgery. British volume, 2009, Volume: 91, Issue:3

    Topics: Adult; Aged; Ankle Injuries; Anticoagulants; Dalteparin; Double-Blind Method; Female; Fractures, Bon

2009

Other Studies

8 other studies available for dalteparin and Injuries, Leg

ArticleYear
Dose-adjusted thrombosis prophylaxis in trauma surgery according to levels of D-Dimer.
    Thrombosis research, 2000, Jun-15, Volume: 98, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Antifibrinolytic Agents; Antithrombin III; Biomarkers; Female; Fibri

2000
Medicine wastage in a thromboprophylaxis protocol for ambulatory trauma patients.
    Emergency nurse : the journal of the RCN Accident and Emergency Nursing Association, 2020, Nov-11, Volume: 28, Issue:6

    Topics: Anticoagulants; Casts, Surgical; Cost Savings; Emergency Service, Hospital; England; Enoxaparin; Fra

2020
Incidence of deep venous thrombosis after temporary joint spanning external fixation for complex lower extremity injuries.
    The Journal of trauma, 2009, Volume: 66, Issue:4

    Topics: Adult; Anticoagulants; Clinical Protocols; Enoxaparin; External Fixators; Female; Fibula; Fracture F

2009
Reviparin after leg injury requiring immobilization.
    The New England journal of medicine, 2003, Mar-13, Volume: 348, Issue:11

    Topics: Anticoagulants; Heparin, Low-Molecular-Weight; Humans; Immobilization; Leg Injuries; Research Design

2003
Reviparin after leg injury requiring immobilization.
    The New England journal of medicine, 2003, Mar-13, Volume: 348, Issue:11

    Topics: Anticoagulants; Heparin, Low-Molecular-Weight; Humans; Immobilization; Leg Injuries; Postoperative C

2003
Reviparin after leg injury requiring immobilization.
    The New England journal of medicine, 2003, Mar-13, Volume: 348, Issue:11

    Topics: Anticoagulants; Heparin, Low-Molecular-Weight; Humans; Immobilization; Incidence; Leg Injuries; Risk

2003
The cost of outpatient venous thromboembolism prophylaxis following lower limb injuries.
    The bone & joint journal, 2013, Volume: 95-B, Issue:5

    Topics: Ambulatory Care; Anticoagulants; Dalteparin; Fracture Fixation; Health Care Costs; Humans; Leg Injur

2013
Low-Molecular-Weight Heparin Did Not Differ from Placebo in Preventing Clinically Important Deep Venous Thrombosis After Surgical Repair of Leg Fracture.
    The Journal of bone and joint surgery. American volume, 2016, Feb-17, Volume: 98, Issue:4

    Topics: Anticoagulants; Dalteparin; Female; Fractures, Bone; Humans; Leg Injuries; Male; Venous Thromboembol

2016