dalteparin has been researched along with Fractures, Bone in 31 studies
Dalteparin: A low-molecular-weight fragment of heparin, prepared by nitrous acid depolymerization of porcine mucosal heparin. The mean molecular weight is 4000-6000 daltons. It is used therapeutically as an antithrombotic agent. (From Merck Index, 11th ed)
Fractures, Bone: Breaks in bones.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Emerging evidence suggests aspirin may be an effective venous thromboembolism (VTE) prophylaxis for orthopaedic trauma patients, with fewer bleeding complications." | 9.34 | Aspirin versus low-molecular-weight heparin for venous thromboembolism prophylaxis in orthopaedic trauma patients: A patient-centered randomized controlled trial. ( Castillo, RC; Haac, BE; Manson, TT; O'Hara, NN; O'Toole, RV; Slobogean, GP; Stein, DM, 2020) |
| "Emerging evidence suggests aspirin may be an effective venous thromboembolism (VTE) prophylaxis for orthopaedic trauma patients, with fewer bleeding complications." | 5.34 | Aspirin versus low-molecular-weight heparin for venous thromboembolism prophylaxis in orthopaedic trauma patients: A patient-centered randomized controlled trial. ( Castillo, RC; Haac, BE; Manson, TT; O'Hara, NN; O'Toole, RV; Slobogean, GP; Stein, DM, 2020) |
| " We report a case of HIT in a postoperative orthopedic 75-year-old woman in treatment with LMWH (nadroparin) complicated by pulmonary embolism and treated successfully with recombinant hirudin." | 3.76 | Heparin-induced thrombocytopenia associated with pulmonary embolism. ( Cei, M; Mumoli, N, 2010) |
| "1." | 1.51 | Underdosing of Prophylactic Enoxaparin Is Common in Orthopaedic Trauma and Predicts 90-Day Venous Thromboembolism. ( Fleming, KI; Higgins, TF; Jones, DL; Jones, WA; Pannucci, CJ; Rothberg, DL; Zhang, Y, 2019) |
| " We sought to investigate if prophylactic enoxaparin dosed by anti-Xa trough levels could reduce clinically evident VTE in trauma patients with lower extremity or pelvic injury." | 1.48 | Trauma patients with lower extremity and pelvic fractures: Should anti-factor Xa trough level guide prophylactic enoxaparin dose? ( Barmparas, G; Dhillon, NK; Gewertz, BL; Gillette, E; Ley, EJ; Mason, R; Smith, EJT, 2018) |
| "After a few days the patient developed deep vein thrombosis of the subclavian, axillary and brachial veins, which was successfully treated with nadroparin." | 1.43 | [Thrombosis of the subclavian vein after conservative treatment of a clavicular fracture: A rare complication]. ( Baecker, H; Haas, NP; Märdian, S; Ranke, H, 2016) |
| "With patients in whom it is indicated, the home therapy ankle pathway has proved to be a safe and resource sparing method of managing ankle fractures prior to surgery." | 1.39 | Home therapy pathway - safe and streamlined method of initial management of ankle fractures. ( Baraza, N; Dhukaram, V; Lever, S, 2013) |
| "A total of 81 patients with long bone fractures were included in the study and divided into two groups." | 1.38 | The influence of low molecular weight heparin on the expression of osteogenic growth factors in human fracture healing. ( Aharinejad, S; Kaiser, G; Michel, M; Mousavi, M; Sarahrudi, K; Thomas, A; Wolf, H, 2012) |
| "Clinically symptomatic proximal deep vein thrombosis (DVT) or pulmonary embolism (PE) rates were 1." | 1.34 | Dalteparin versus enoxaparin for venous thromboembolism prophylaxis in acute spinal cord injury and major orthopedic trauma patients: 'DETECT' trial. ( Chan, E; Chittock, D; de Lemos, J; Gorman, SK; Ho, SG; Simons, RK; Slavik, RS; Wing, PC, 2007) |
| "The overall deep vein thrombosis (DVT) rate in group 1 was 3." | 1.31 | Dose-adjusted thrombosis prophylaxis in trauma surgery according to levels of D-Dimer. ( Hafner, G; Hansen, M; Mayer, A; Peetz, D; Prellwitz, W; Rippin, G; Rommens, PM, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (6.45) | 18.2507 |
| 2000's | 9 (29.03) | 29.6817 |
| 2010's | 14 (45.16) | 24.3611 |
| 2020's | 6 (19.35) | 2.80 |
| Authors | Studies |
|---|---|
| Ranke, H | 1 |
| Märdian, S | 1 |
| Haas, NP | 1 |
| Baecker, H | 1 |
| Mumoli, N | 1 |
| Cei, M | 1 |
| Mironov, SP | 1 |
| Burmakova, GM | 1 |
| Fedotova, TM | 1 |
| Peetz, D | 1 |
| Hafner, G | 1 |
| Hansen, M | 1 |
| Mayer, A | 1 |
| Rippin, G | 1 |
| Rommens, PM | 1 |
| Prellwitz, W | 1 |
| Kaplunov, OA | 1 |
| Kaplunov, KO | 1 |
| Leone, S | 1 |
| Zuccoli, ML | 1 |
| Fucile, C | 1 |
| Storace, S | 1 |
| Martelli, A | 1 |
| Mattioli, F | 1 |
| Griffin, M | 1 |
| Lip, GYH | 1 |
| Ebell, MH | 1 |
| Jones, DL | 1 |
| Jones, WA | 1 |
| Fleming, KI | 1 |
| Higgins, TF | 1 |
| Rothberg, DL | 1 |
| Zhang, Y | 1 |
| Pannucci, CJ | 1 |
| Lee, JK | 1 |
| Koo, JW | 1 |
| Jeong, SY | 1 |
| Choi, S | 1 |
| Park, KC | 1 |
| Hwang, KT | 1 |
| Haac, BE | 1 |
| O'Hara, NN | 1 |
| Manson, TT | 1 |
| Slobogean, GP | 1 |
| Castillo, RC | 1 |
| O'Toole, RV | 1 |
| Stein, DM | 1 |
| Mower, S | 1 |
| Thompson, S | 1 |
| Dhillon, NK | 1 |
| Smith, EJT | 1 |
| Gillette, E | 1 |
| Mason, R | 1 |
| Barmparas, G | 1 |
| Gewertz, BL | 1 |
| Ley, EJ | 1 |
| Suto, Y | 1 |
| Nagata, K | 1 |
| Ahmed, SM | 1 |
| Jacovides, CL | 1 |
| Browne, KD | 1 |
| Cognetti, J | 1 |
| Johnson, VE | 1 |
| Leone, R | 1 |
| Kaplan, LJ | 1 |
| Smith, DH | 1 |
| Pascual, JL | 1 |
| Baraza, N | 1 |
| Lever, S | 1 |
| Dhukaram, V | 1 |
| Stiefelhagen, P | 1 |
| Nwachukwu, U | 1 |
| Tsiridis, E | 1 |
| Gamie, Z | 1 |
| George, MJ | 1 |
| Hamilton-Baille, D | 1 |
| West, RM | 1 |
| Giannoudis, PV | 1 |
| Sarahrudi, K | 1 |
| Kaiser, G | 1 |
| Thomas, A | 1 |
| Michel, M | 1 |
| Wolf, H | 1 |
| Mousavi, M | 1 |
| Aharinejad, S | 1 |
| Stannard, JP | 1 |
| Singhania, AK | 1 |
| Lopez-Ben, RR | 1 |
| Anderson, ER | 1 |
| Farris, RC | 1 |
| Volgas, DA | 1 |
| McGwin, GR | 1 |
| Alonso, JE | 1 |
| Nadir, Y | 1 |
| Mazor, Y | 1 |
| Reuven, B | 1 |
| Sarig, G | 1 |
| Brenner, B | 1 |
| Krivoy, N | 1 |
| Slavik, RS | 1 |
| Chan, E | 1 |
| Gorman, SK | 1 |
| de Lemos, J | 1 |
| Chittock, D | 1 |
| Simons, RK | 1 |
| Wing, PC | 1 |
| Ho, SG | 1 |
| Langford, JR | 1 |
| Trokhan, S | 1 |
| Strauss, E | 1 |
| Rachmani, R | 1 |
| Levi, Z | 1 |
| Zissin, R | 1 |
| Bernheim, J | 1 |
| Korzets, Z | 1 |
| Walenga, JM | 1 |
| Kaiser, PC | 1 |
| Prechel, MM | 1 |
| Hoppensteadt, D | 1 |
| Jeske, WP | 1 |
| Misselwitz, F | 1 |
| Bacher, P | 1 |
| Lassen, MR | 2 |
| Fareed, J | 1 |
| Borris, LC | 1 |
| Nakov, RL | 1 |
| DePaula, KM | 1 |
| deLaorcade, AM | 1 |
| King, RG | 1 |
| Hughs, H | 1 |
| Boudrieau, RJ | 1 |
| Selby, R | 1 |
| Geerts, WH | 1 |
| Kreder, HJ | 1 |
| Crowther, MA | 1 |
| Kaus, L | 1 |
| Sealey, F | 1 |
| Little, MT | 1 |
| Goel, DP | 1 |
| Buckley, R | 1 |
| deVries, G | 1 |
| Abelseth, G | 1 |
| Ni, A | 1 |
| Gray, R | 1 |
| Pettilä, V | 1 |
| Kaaja, R | 1 |
| Leinonen, P | 1 |
| Ekblad, U | 1 |
| Kataja, M | 1 |
| Ikkala, E | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Different Approach to Preventing Thrombosis (ADAPT): A Randomized Controlled Trial Comparing Low Molecular Weight Heparin to Acetylsalicylic Acid in Orthopedic Trauma Patients[NCT02774265] | Phase 3 | 329 participants (Actual) | Interventional | 2016-01-31 | Completed | ||
| Evaluation of the Prevention of Thromboembolic Disease in Patients With a Lower Limb Trauma, Non Surgical, in Winter Sports Resort.[NCT01303523] | 1,627 participants (Actual) | Observational | 2010-12-31 | Completed | |||
| Clinically-Important Venous Thromboembolism Following Lower Extremity Fractures: Epidemiology & Prevention[NCT00187408] | Phase 4 | 700 participants | Interventional | 2002-08-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
DVT and how the diagnosis was made will be recorded. The number of events in participants in each arm will be compared to evaluate efficacy. (NCT02774265)
Timeframe: 90 days
| Intervention | Participants (Count of Participants) |
|---|---|
| VTE Prophylaxis With Enoxaparin 30mg BID | 5 |
| VTE Prophylaxis With Aspirin 81mg BID | 9 |
Bases on imaging obtained for symptoms. (NCT02774265)
Timeframe: 90 days
| Intervention | Participants (Count of Participants) |
|---|---|
| VTE Prophylaxis With Enoxaparin 30mg BID | 6 |
| VTE Prophylaxis With Aspirin 81mg BID | 2 |
Includes a greater than 2g/dL drop in hemoglobin, blood transfusion, hematoma evacuation, re-operation for a deep surgical site infection or minor procedure for bleeding and GI bleed (NCT02774265)
Timeframe: 90 days
| Intervention | Participants (Count of Participants) |
|---|---|
| VTE Prophylaxis With Enoxaparin 30mg BID | 52 |
| VTE Prophylaxis With Aspirin 81mg BID | 53 |
2 reviews available for dalteparin and Fractures, Bone
| Article | Year |
|---|---|
Heparin-induced acute adverse reaction--case report of a patient with acute trauma and a genetic predisposition to thrombotic events: a concurrence of events.
Topics: Ankle Injuries; Anticoagulants; Drug Hypersensitivity; Fractures, Bone; Genetic Predisposition to Di | 2012 |
Early postoperative bleeding in polytrauma patients treated with fondaparinux: literature review and institutional experience.
Topics: Acetabulum; Adult; Anticoagulants; Enoxaparin; Female; Fondaparinux; Fractures, Bone; Humans; Male; | 2011 |
7 trials available for dalteparin and Fractures, Bone
| Article | Year |
|---|---|
Aspirin versus low-molecular-weight heparin for venous thromboembolism prophylaxis in orthopaedic trauma patients: A patient-centered randomized controlled trial.
Topics: Adult; Aged; Anticoagulants; Aspirin; Enoxaparin; Female; Fibrinolytic Agents; Fractures, Bone; Hemo | 2020 |
Early postoperative bleeding in polytrauma patients treated with fondaparinux: literature review and institutional experience.
Topics: Acetabulum; Adult; Anticoagulants; Enoxaparin; Female; Fondaparinux; Fractures, Bone; Humans; Male; | 2011 |
Sustained release of tissue factor following thrombosis of lower limb trauma.
Topics: Achilles Tendon; Anticoagulants; Double-Blind Method; Female; Fractures, Bone; Heparin, Low-Molecula | 2014 |
Use of the low-molecular-weight heparin reviparin to prevent deep-vein thrombosis after leg injury requiring immobilization.
Topics: Achilles Tendon; Adult; Anticoagulants; Braces; Casts, Surgical; Double-Blind Method; Female; Fractu | 2002 |
Use of the low-molecular-weight heparin reviparin to prevent deep-vein thrombosis after leg injury requiring immobilization.
Topics: Achilles Tendon; Adult; Anticoagulants; Braces; Casts, Surgical; Double-Blind Method; Female; Fractu | 2002 |
Use of the low-molecular-weight heparin reviparin to prevent deep-vein thrombosis after leg injury requiring immobilization.
Topics: Achilles Tendon; Adult; Anticoagulants; Braces; Casts, Surgical; Double-Blind Method; Female; Fractu | 2002 |
Use of the low-molecular-weight heparin reviparin to prevent deep-vein thrombosis after leg injury requiring immobilization.
Topics: Achilles Tendon; Adult; Anticoagulants; Braces; Casts, Surgical; Double-Blind Method; Female; Fractu | 2002 |
A double-blind, randomized controlled trial of the prevention of clinically important venous thromboembolism after isolated lower leg fractures.
Topics: Adult; Aged; Ankle Fractures; Anticoagulants; Dalteparin; Double-Blind Method; Female; Fibula; Fract | 2015 |
A double-blind, randomized controlled trial of the prevention of clinically important venous thromboembolism after isolated lower leg fractures.
Topics: Adult; Aged; Ankle Fractures; Anticoagulants; Dalteparin; Double-Blind Method; Female; Fibula; Fract | 2015 |
A double-blind, randomized controlled trial of the prevention of clinically important venous thromboembolism after isolated lower leg fractures.
Topics: Adult; Aged; Ankle Fractures; Anticoagulants; Dalteparin; Double-Blind Method; Female; Fibula; Fract | 2015 |
A double-blind, randomized controlled trial of the prevention of clinically important venous thromboembolism after isolated lower leg fractures.
Topics: Adult; Aged; Ankle Fractures; Anticoagulants; Dalteparin; Double-Blind Method; Female; Fibula; Fract | 2015 |
Prophylaxis of deep-vein thrombosis in fractures below the knee: a prospective randomised controlled trial.
Topics: Adult; Aged; Ankle Injuries; Anticoagulants; Dalteparin; Double-Blind Method; Female; Fractures, Bon | 2009 |
Thromboprophylaxis with low molecular weight heparin (dalteparin) in pregnancy.
Topics: Adult; Dalteparin; Demography; Female; Fractures, Bone; Hemorrhage; Heparin; Heparin, Low-Molecular- | 1999 |
23 other studies available for dalteparin and Fractures, Bone
| Article | Year |
|---|---|
[Thrombosis of the subclavian vein after conservative treatment of a clavicular fracture: A rare complication].
Topics: Adolescent; Bandages; Clavicle; Conservative Treatment; Fibrinolytic Agents; Fractures, Bone; Humans | 2016 |
Heparin-induced thrombocytopenia associated with pulmonary embolism.
Topics: Aged; Antibodies; Female; Fibrinolytic Agents; Fractures, Bone; Hirudins; Humans; Nadroparin; Orthop | 2010 |
[The use of fraxiparin in orthopedic trauma patients to prevent and treat pulmonary embolism and deep venous thrombosis of the extremities].
Topics: Adult; Drug Evaluation; Female; Fractures, Bone; Humans; Knee Injuries; Male; Middle Aged; Nadropari | 1993 |
Dose-adjusted thrombosis prophylaxis in trauma surgery according to levels of D-Dimer.
Topics: Adult; Aged; Aged, 80 and over; Antifibrinolytic Agents; Antithrombin III; Biomarkers; Female; Fibri | 2000 |
[The use of parnaparin sodium (Fluxum) in the prevention of thromboembolic complications after surgical treatment of fractures associated with high risks of thrombosis].
Topics: Anticoagulants; Enoxaparin; Fracture Fixation; Fractures, Bone; Heparin, Low-Molecular-Weight; Human | 2020 |
In limb or pelvic fracture, aspirin was noninferior to enoxaparin for reducing all-cause death.
Topics: Anticoagulants; Aspirin; Enoxaparin; Extremities; Fractures, Bone; Humans; Venous Thromboembolism | 2023 |
Twice-Daily Low-Dose Aspirin Is Similar to Enoxaparin for Thromboprophylaxis After Inpatient Treatment for Fracture.
Topics: Anticoagulants; Aspirin; Enoxaparin; Fractures, Bone; Humans; Inpatients; Venous Thromboembolism | 2023 |
Underdosing of Prophylactic Enoxaparin Is Common in Orthopaedic Trauma and Predicts 90-Day Venous Thromboembolism.
Topics: Academic Medical Centers; Adult; Aged; Anticoagulants; Cohort Studies; Dose-Response Relationship, D | 2019 |
Perioperative symptomatic venous thromboembolism after immediate chemoprophylaxis in patients with pelvic and lower-extremity fractures.
Topics: Adult; Aged; Anticoagulants; Bones of Lower Extremity; Chemoprevention; Dabigatran; Enoxaparin; Fema | 2020 |
Medicine wastage in a thromboprophylaxis protocol for ambulatory trauma patients.
Topics: Anticoagulants; Casts, Surgical; Cost Savings; Emergency Service, Hospital; England; Enoxaparin; Fra | 2020 |
Trauma patients with lower extremity and pelvic fractures: Should anti-factor Xa trough level guide prophylactic enoxaparin dose?
Topics: Adult; Anticoagulants; Blood Coagulation Tests; Enoxaparin; Factor Xa Inhibitors; Female; Fractures, | 2018 |
Cerebral Edema and Neurological Recovery after Traumatic Brain Injury Are Worsened if Accompanied by a Concomitant Long Bone Fracture.
Topics: Animals; Anticoagulants; Brain Edema; Brain Injuries, Traumatic; Enoxaparin; Fractures, Bone; Male; | 2019 |
Home therapy pathway - safe and streamlined method of initial management of ankle fractures.
Topics: Adult; Aged; Aged, 80 and over; Ankle Injuries; Anticoagulants; Case-Control Studies; Casts, Surgica | 2013 |
[Leg venous thrombosis after work accident: serious surprise in echocardiography].
Topics: Accidents, Occupational; Adult; Casts, Surgical; Critical Care; Echocardiography, Doppler, Color; En | 2008 |
Health trends.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Blood Glucose; Bone Density Conservation Ag | 2010 |
The influence of low molecular weight heparin on the expression of osteogenic growth factors in human fracture healing.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticoagulants; Enoxaparin; Enzyme-Linked Immunosorbent | 2012 |
Deep-vein thrombosis in high-energy skeletal trauma despite thromboprophylaxis.
Topics: Acetabulum; Enoxaparin; Fibrinolytic Agents; Fractures, Bone; Humans; Magnetic Resonance Angiography | 2005 |
A fatal case of enoxaparin induced skin necrosis and thrombophilia.
Topics: Aged; Anticoagulants; Diagnosis, Differential; Drug Eruptions; Enoxaparin; Factor V; Factor VIII; Fa | 2006 |
Dalteparin versus enoxaparin for venous thromboembolism prophylaxis in acute spinal cord injury and major orthopedic trauma patients: 'DETECT' trial.
Topics: Adult; Cohort Studies; Dalteparin; Drug Administration Schedule; Enoxaparin; Female; Fibrinolytic Ag | 2007 |
External iliac artery thrombosis after open reduction of an acetabular fracture: a case report.
Topics: Acetabulum; Adult; Angiography; Anticoagulants; Enoxaparin; Female; Fracture Fixation, Internal; Fra | 2008 |
Acute renal failure and paraplegia in a patient with a pelvic-ring fracture.
Topics: Acute Kidney Injury; Anticoagulants; Enoxaparin; Fractures, Bone; Hematoma; Humans; Hydronephrosis; | 2000 |
Arterial thrombosis after vehicular trauma and humeral fracture in a dog.
Topics: Accidents, Traffic; Animals; Anticoagulants; Clopidogrel; Dalteparin; Dog Diseases; Dogs; Female; Fo | 2013 |
Low-Molecular-Weight Heparin Did Not Differ from Placebo in Preventing Clinically Important Deep Venous Thrombosis After Surgical Repair of Leg Fracture.
Topics: Anticoagulants; Dalteparin; Female; Fractures, Bone; Humans; Leg Injuries; Male; Venous Thromboembol | 2016 |