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dalteparin and Complications, Hematologic Pregnancy

dalteparin has been researched along with Complications, Hematologic Pregnancy in 84 studies

Dalteparin: A low-molecular-weight fragment of heparin, prepared by nitrous acid depolymerization of porcine mucosal heparin. The mean molecular weight is 4000-6000 daltons. It is used therapeutically as an antithrombotic agent. (From Merck Index, 11th ed)

Research Excerpts

ExcerptRelevanceReference
"Our results suggest that the use of long-term prophylactic dalteparin in pregnancy is not associated with a significant decrease in BMD."9.12Long-term dalteparin in pregnancy not associated with a decrease in bone mineral density: substudy of a randomized controlled trial. ( Clement, AM; Cranney, A; Hague, WM; Hodsman, A; Kahn, SR; Kovacs, MJ; Lazo-Langner, A; Rodger, MA, 2007)
"Anti-Xa activity levels were used to assess prophylactic (33 women) and therapeutic (15 women) dalteparin dosage throughout pregnancy."9.09Prophylaxis and treatment of thromboembolic diseases during pregnancy with dalteparin. ( Rey, E; Rivard, GE, 2000)
"Nine studies, including data of 1228 women, were included in the review evaluating the effect of either LMWH (enoxaparin or nadroparin in varying doses) or aspirin or a combination of both, on the chance of live birth in women with recurrent miscarriage, with or without inherited thrombophilia."8.90Aspirin and/or heparin for women with unexplained recurrent miscarriage with or without inherited thrombophilia. ( de Jong, PG; Di Nisio, M; Goddijn, M; Kaandorp, S; Middeldorp, S, 2014)
"Dysfibrinogenemia is caused by a variety of structural abnormalities in the fibrinogen molecule, which results in a tendency for bleeding and thrombosis as well as obstetric complications."7.75Treatment of patients with dysfibrinogenemia and a history of abortions during pregnancy. ( Galanakis, D; Miesbach, W; Scharrer, I, 2009)
"Data from this retrospective cohort study suggest that combined treatment with dalteparin and ASA decreases the risk of preeclampsia by 20% and the risk of FGR by 30% in women with inherited thrombophilia."7.74Dalteparin and low-dose aspirin in the prevention of adverse obstetric outcomes in women with inherited thrombophilia. ( David, M; Dubois, E; Leduc, L; Rey, E; Takser, L, 2007)
" No adverse maternal-fetal side effects were reported on enoxaparin alone or enoxaparin-metformin."6.74Enoxaparin-metformin and enoxaparin alone may safely reduce pregnancy loss. ( Glueck, CJ; Goldenberg, N; Khan, N; Ramidi, G; Wang, P, 2009)
"Hypercoagulability is observed in patients with inherited thrombophilia, e."6.70The impact of dalteparin (Fragmin) on thrombin generation in pregnant women with venous thromboembolism: significance of the factor V Leiden mutation. ( Eberl, E; Geisen, U; Grossmann, R; Keller, F; Schambeck, CM, 2001)
"Dalteparin or dextran was used during delivery."6.69Thromboprophylaxis with low molecular mass heparin, 'Fragmin' (dalteparin), during pregnancy--a longitudinal safety study. ( Blombäck, M; Bremme, K; Hellgren, M; Lindberg, H; Siegbahn, A, 1998)
"Screening results for thrombophilia and antithrombotic treatment with enoxaparin, aspirin, or both and pregnancy outcomes."5.27The Prevalence of Thrombophilia in Women With Recurrent Fetal Loss and Outcome of Anticoagulation Therapy for the Prevention of Miscarriages. ( Elias, A; Elias, M; Nahas, R; Saliba, W, 2018)
"Our results suggest that the use of long-term prophylactic dalteparin in pregnancy is not associated with a significant decrease in BMD."5.12Long-term dalteparin in pregnancy not associated with a decrease in bone mineral density: substudy of a randomized controlled trial. ( Clement, AM; Cranney, A; Hague, WM; Hodsman, A; Kahn, SR; Kovacs, MJ; Lazo-Langner, A; Rodger, MA, 2007)
" In a randomised open study, 44 pregnant women with confirmed previous or current thromboembolism were randomised to receive either low-molecular-weight heparin, dalteparin (N = 21) once daily subcutaneously or unfractionated sodium heparin (UF heparin, N = 23) twice daily subcutaneously for thromboprophylaxis during pregnancy and puerperium."5.10Postpartum bone mineral density in women treated for thromboprophylaxis with unfractionated heparin or LMW heparin. ( Hiilesmaa, V; Kaaja, R; Leinonen, P; Markkola, A; Pettilä, V, 2002)
"Anti-Xa activity levels were used to assess prophylactic (33 women) and therapeutic (15 women) dalteparin dosage throughout pregnancy."5.09Prophylaxis and treatment of thromboembolic diseases during pregnancy with dalteparin. ( Rey, E; Rivard, GE, 2000)
"Nine studies, including data of 1228 women, were included in the review evaluating the effect of either LMWH (enoxaparin or nadroparin in varying doses) or aspirin or a combination of both, on the chance of live birth in women with recurrent miscarriage, with or without inherited thrombophilia."4.90Aspirin and/or heparin for women with unexplained recurrent miscarriage with or without inherited thrombophilia. ( de Jong, PG; Di Nisio, M; Goddijn, M; Kaandorp, S; Middeldorp, S, 2014)
"Dysfibrinogenemia is caused by a variety of structural abnormalities in the fibrinogen molecule, which results in a tendency for bleeding and thrombosis as well as obstetric complications."3.75Treatment of patients with dysfibrinogenemia and a history of abortions during pregnancy. ( Galanakis, D; Miesbach, W; Scharrer, I, 2009)
"Data from this retrospective cohort study suggest that combined treatment with dalteparin and ASA decreases the risk of preeclampsia by 20% and the risk of FGR by 30% in women with inherited thrombophilia."3.74Dalteparin and low-dose aspirin in the prevention of adverse obstetric outcomes in women with inherited thrombophilia. ( David, M; Dubois, E; Leduc, L; Rey, E; Takser, L, 2007)
"Heparin prophylaxis at fixed low doses and possibly aspirin could be efficacious in preventing adverse outcomes in women carrying inherited thrombophilia with previous poor obstetric outcomes."3.71Preventing adverse obstetric outcomes in women with genetic thrombophilia. ( Brancaccio, V; Colaizzo, D; Di Minno, G; Grandone, E; Margaglione, M; Pavone, G; Sciannamé, N, 2002)
" Aspirin, 75 mg daily was given in addition to enoxaparin to women with antiphospholipid syndrome."3.70Gestational outcome in thrombophilic women with recurrent pregnancy loss treated by enoxaparin. ( Blumenfeld, Z; Brenner, B; Hoffman, R; Weiner, Z; Younis, JS, 2000)
"Aspirin and heparin have been shown to have potentially beneficial effects on trophoblast implantation."2.79Low dose aspirin and low-molecular-weight heparin in the treatment of pregnant Libyan women with recurrent miscarriage. ( Adam, I; Ashur, BM; Elbareg, AM; Elmahashi, MO; Essadi, FM, 2014)
"Weight-based dosing of tinzaparin failed to achieve therapeutic anticoagulation in the vast majority of women, although clinical outcomes were good."2.78Weight-adjusted dosing of tinzaparin in pregnancy. ( Gibson, PS; Jiang, X; Mansoor, A; Newell, K; Ross, S; Sam, DX; Tang, S, 2013)
" No adverse maternal-fetal side effects were reported on enoxaparin alone or enoxaparin-metformin."2.74Enoxaparin-metformin and enoxaparin alone may safely reduce pregnancy loss. ( Glueck, CJ; Goldenberg, N; Khan, N; Ramidi, G; Wang, P, 2009)
" Using enoxaparin pharmacokinetic parameters to simulate anti-Xa time profiles, we observed that the maintenance of the same doses throughout pregnancy resulted in a progressive reduction in mean and peak anti-Xa activities."2.73Changes in enoxaparin pharmacokinetics during pregnancy and implications for antithrombotic therapeutic strategy. ( Amoura, Z; Ankri, A; Conard, J; Cornet, A; Costedoat-Chalumeau, N; Dommergues, M; Hulot, JS; Lebaudy, C; Lechat, P; Piette, JC; Serreau, R, 2008)
"Hypercoagulability is observed in patients with inherited thrombophilia, e."2.70The impact of dalteparin (Fragmin) on thrombin generation in pregnant women with venous thromboembolism: significance of the factor V Leiden mutation. ( Eberl, E; Geisen, U; Grossmann, R; Keller, F; Schambeck, CM, 2001)
"Dalteparin or dextran was used during delivery."2.69Thromboprophylaxis with low molecular mass heparin, 'Fragmin' (dalteparin), during pregnancy--a longitudinal safety study. ( Blombäck, M; Bremme, K; Hellgren, M; Lindberg, H; Siegbahn, A, 1998)
"Women with thrombophilia have an increased risk of pregnancy loss and possibly other serious obstetric complications, although definition of the magnitude of risk will require prospective longitudinal studies."2.42Thrombophilia and pregnancy complications. ( Kujovich, JL, 2004)
"The third pregnancy was established and sintrom was stopped and replaced by fraxiparine 0."2.40[Successful prophylaxis in a pregnancy with thrombophilic states]. ( Bogdanova, M; Iankova, Z, 1999)
"Thrombophilia was present in 38 (33."1.46Outcomes of threatened abortions after anticoagulation treatment to prevent recurrent pregnancy loss. ( Amsalem, H; Kalish, Y; Kleinstern, G; Rottenstreich, A, 2017)
"These findings suggest that vertebral compression fractures and PPO may be one of the causes of severe back pain in postpartum patients."1.42Postpartum osteoporosis and vertebral fractures in two patients treated with enoxaparin during pregnancy. ( Cakir, B; Dirikoc, A; Ersoy, R; Ozdemir, D; Tam, AA, 2015)
"Among patients with cancer-related VTE, 59."1.38Management and adherence to VTE treatment guidelines in a national prospective cohort study in the Canadian outpatient setting. The Recovery Study. ( Blostein, M; Faucher, JP; Gamble, G; Game, M; Gordon, W; Kagoma, PK; Kahn, SR; Komari, N; Laverdière, D; Martineau, J; McLeod, A; Mills, A; Miron, MJ; Schulman, S; Springmann, V; Stewart, JA; Strulovitch, C, 2012)
" The primary outcome was change in dosing requirements of LMWH throughout pregnancy as determined by the corresponding antifactor Xa activity peak levels."1.37Dosing and monitoring of low-molecular-weight heparin in high-risk pregnancy: single-center experience. ( Chevalier, AB; Hibbard, JU; Kominiarek, MA; Nutescu, EA; Shapiro, NL, 2011)
"The incidence of severe pregnancy complications in previous pregnancies was similar in both groups."1.37Low molecular weight heparin treatment during subsequent pregnancies of women with inherited thrombophilia and previous severe pregnancy complications. ( Gamzu, R; Kupferminc, MJ; Lessing, JB; Many, A; Rimon, E; Sharon, M, 2011)
"No reductions were observed in the thrombus size or mean mitral gradient on transesophageal echocardiography (TEE) with 1 week of unfractioned heparin therapy."1.37Partial thrombus resolution with trofiban in a pregnant woman with mechanical prosthetic mitral valve thrombosis. ( Akcay, AB; Akcay, M; Davutoglu, V; Sen, N; Soydinc, HE; Yuce, M, 2011)
"Inherited thrombophilia is associated with thromboembolic events and/or poor obstetric outcome."1.33Inherited thrombophilia: treatment during pregnancy. ( Caruso, A; De Carolis, S; De Stefano, V; Fatigante, G; Ferrazzani, S; Garofalo, S; Leone, G; Rossi, E, 2006)
"Lovenox (enoxaparin sodium) therapy appears to be safe and efficacious for pregnant women who are candidates for either prophylactic or therapeutic heparin."1.31ACOG Committee Opinion: safety of Lovenox in pregnancy. ( , 2002)
"The incidence of adverse events reported could be explained by the high risk profile of the study population."1.31Venous thromboembolism during pregnancy: a retrospective study of enoxaparin safety in 624 pregnancies. ( Borel-Derlon, A; Borg, JY; Boudignat, O; Cohen, C; Conard, J; Darmon, JY; Francoual, C; Lepercq, J; Priollet, P; Schved, JF; Tournaire, M; Yvelin, N, 2001)
" The mean time for dosage increase was 20."1.30Thromboprophylaxis with low molecular weight heparin (Fragmin) in high risk pregnancies. ( Buchanan, N; Copplestone, A; Doughty, HA; Hughes, G; Hunt, BJ; Kerslake, S; Khamashta, M; Majumdar, G, 1997)

Research

Studies (84)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's11 (13.10)18.2507
2000's46 (54.76)29.6817
2010's25 (29.76)24.3611
2020's2 (2.38)2.80

Authors

AuthorsStudies
Simeone, R1
Giacomello, R1
Bruno, G1
Parco, S1
Maximova, N1
Martinelli, M1
Zito, G1
Luppi, S1
Cervi, G1
Ricci, G1
de Jong, PG1
Kaandorp, S1
Di Nisio, M1
Goddijn, M1
Middeldorp, S1
Makatsaria, AD1
Bitsadze, VO1
Dolgushina, NV1
Lewandowski, K1
Balcerzak, A1
Kubiaczyk-Paluch, B1
Breborowicz, GH1
Martinelli, P1
Maruotti, GM1
Coppola, A1
Agangi, A1
Paladini, D1
Grandone, E3
Di Minno, G2
Barkagan, ZS1
Llau, JV1
Hoyas, L1
Ezpeleta, J1
García-Polit, J1
Boda, Z1
László, P1
Pfliegler, G1
Tornai, I1
Rejtö, L1
Schlammadinger, A1
Iankova, Z1
Bogdanova, M1
Alalaf, SK1
Jawad, RK1
Muhammad, PR1
Ali, MS1
Al Tawil, NG1
Nasich, LL1
Hoffman, R3
Keren-Politansky, A1
Jabareen, A1
Kalish, Y2
Schliamser, L1
Brenner, B6
Nadir, Y1
Aleidan, FAS1
Aljarba, GA1
Aldakhil, AA1
Allehyani, BI1
Yahia, MA1
Alghtani, NE1
Badri, M1
Alaklabi, AA1
Alsuhaibani, A1
Crowther, MA1
Rottenstreich, A1
Amsalem, H1
Kleinstern, G1
Vianello, A1
Vencato, E1
Cantini, M1
Zanconato, G1
Manfrin, E1
Zamo, A1
Zorzi, F1
Mazzi, F1
Martinelli, N1
Cavaliere, E1
Monari, F1
Venturelli, D1
Ferrara, F1
Olivieri, O1
De Franceschi, L1
Lucania, G1
Camiolo, E1
Carmina, MG1
Fiandaca, T1
Indovina, A1
Malato, A1
Messina, R1
Fabbiano, F1
Marcenò, R1
Elmahashi, MO1
Elbareg, AM1
Essadi, FM1
Ashur, BM1
Adam, I1
Hauck-Dlimi, B1
Zimmermann, R1
Eckstein, R1
Ringwald, J1
Ozdemir, D1
Tam, AA1
Dirikoc, A1
Ersoy, R1
Cakir, B1
Salim, R1
Nachum, Z1
Gavish, I1
Romano, S1
Braverman, M1
Garmi, G1
Nahas, R1
Saliba, W1
Elias, A1
Elias, M1
Ramidi, G1
Khan, N2
Glueck, CJ3
Wang, P3
Goldenberg, N2
Forsnes, E1
Occhino, A1
Acosta, R1
Miesbach, W1
Galanakis, D1
Scharrer, I1
Salomon, O1
Dulitzky, M1
Apter, S1
Friedrich, E1
Hameed, AB1
Sudrová, M1
Kvasnička, J1
Kudrnová, Z1
Zenáhlíková, Z1
Mazoch, J1
Brzežková, R1
Akcay, AB1
Yuce, M1
Akcay, M1
Sen, N1
Soydinc, HE1
Davutoglu, V1
Pranikoff, J1
Riaz, K1
Chavan, K1
Raj, P1
Umar, M1
Kupferminc, MJ1
Rimon, E1
Many, A1
Sharon, M1
Lessing, JB1
Gamzu, R1
Shapiro, NL1
Kominiarek, MA1
Nutescu, EA1
Chevalier, AB1
Hibbard, JU1
Kahn, SR4
Springmann, V1
Schulman, S1
Martineau, J1
Stewart, JA1
Komari, N1
McLeod, A1
Strulovitch, C1
Blostein, M2
Faucher, JP1
Gamble, G1
Gordon, W1
Kagoma, PK1
Miron, MJ1
Laverdière, D1
Game, M1
Mills, A1
Figueiró-Filho, EA1
de Oliveira, VM1
Breda, I1
Coelho, LR1
Ferreira, CM1
Brancaccio, V1
Colaizzo, D2
Sciannamé, N1
Pavone, G1
Margaglione, M2
Bergmann, JF1
Mouly, S1
Kaaja, RJ1
Ulander, VM2
Carp, H2
Dolitzky, M1
Inbal, A1
McLintock, C1
North, RA1
White, HD1
Kujovich, JL1
Sieve, L1
Lindqvist, PG3
Merlo, J1
Gris, JC2
Marès, P2
Dulitsky, M1
Younis, J1
Sarig, G1
Blumenfeld, Z2
Leiba, R1
Lanir, N2
Thamban, S1
Opemuyi, IO1
Swinhoe, JR1
Cochrane, GW1
De Carolis, S1
Ferrazzani, S1
De Stefano, V2
Garofalo, S1
Fatigante, G1
Rossi, E2
Leone, G1
Caruso, A1
Puértolas Ortega, M1
Izquierdo Villarroya, B1
Oliva Perales, P1
Lafuente Ojeda, N1
Izquierdo Villarroya, J1
Ruiz Pérez, R1
Bick, RL1
Cappucci, F1
Lebaudy, C1
Hulot, JS1
Amoura, Z1
Costedoat-Chalumeau, N1
Serreau, R1
Ankri, A1
Conard, J2
Cornet, A1
Dommergues, M1
Piette, JC1
Lechat, P1
Luzardo, GE1
Karlnoski, RA1
Williams, B1
Mangar, D1
Camporesi, EM1
Neveu, S1
Tailland, ML1
Courtieu, C1
Schved, JF2
Finkelstein, Y1
Aloni, D1
Kimia, A1
Sommer, R1
Sirota, L1
Brennand, JE1
Walker, ID1
Greer, IA1
Barjot, P1
Beucher, G1
Le Querrec, A1
Derlon-Borel, A1
Herlicoviez, M1
Younis, JS2
Ohel, G1
Haddad, S1
Ben-Ami, M1
Weiner, Z1
Dahlbäck, B1
Berndt, N1
Khan, I1
Gallo, R1
Lepercq, J1
Borel-Derlon, A1
Darmon, JY1
Boudignat, O1
Francoual, C1
Priollet, P1
Cohen, C1
Yvelin, N1
Tournaire, M1
Borg, JY1
Breddin, HK1
Hecking, C1
Hendelmeier, M1
von Bardeleben, R1
Gröschel, K1
Schinzel, H1
Rodger, MA2
Phillips, P1
James, AH1
Konkle, BA1
Gerdsen, F1
Luxembourg, B1
Langer, F1
Bauersachs, R1
Lindhoff-Last, E1
Isma, N1
Svensson, PJ1
Lindblad, B1
Stenqvist, P1
Kaaja, R3
Abou-Nassar, K1
Kovacs, MJ2
Wells, P1
Doucette, S1
Ramsay, T1
Clement, AM2
Khurana, R1
Mackinnon, K1
Solymoss, S1
Kingdom, J1
Sermer, M1
Rey, E3
Rodger, M1
Cranney, A1
Hodsman, A1
Lazo-Langner, A1
Hague, WM1
Leduc, L1
Dubois, E1
Takser, L1
David, M1
Hunt, BJ1
Doughty, HA1
Majumdar, G1
Copplestone, A1
Kerslake, S1
Buchanan, N1
Hughes, G1
Khamashta, M1
Drouet, M1
Le Sellin, J1
Sabbah, A1
Blombäck, M2
Bremme, K2
Hellgren, M1
Siegbahn, A1
Lindberg, H1
Rivard, GE1
Schambeck, CM1
Eberl, E1
Geisen, U1
Grossmann, R1
Keller, F1
Pettilä, V2
Leinonen, P2
Ylikorkala, O1
Taylor, AA1
Markkola, A1
Hiilesmaa, V1
Antovic, A1
He, S1
Khalifeh, A1
Grantham, J1
Byrne, J1
Murphy, K2
McAuliffe, F2
Byrne, B2
Ní Ainle, F1
Wong, A1
Appleby, N1
Regan, C1
Hassan, T1
Milner, M1
Sullivan, AO1
White, B1
O'Donnell, J1
Higgins, M1
Downey, R1
Gibson, PS1
Newell, K1
Sam, DX1
Mansoor, A1
Jiang, X1
Tang, S1
Ross, S1
Sharif, S1
Hay, CR1
Clayton-Smith, J1

Clinical Trials (11)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Hydroxychloroquine in Unexplained Recurrent Pregnancy Loss ,Double Blinded Randomized Controlled Trial .[NCT05237843]Phase 170 participants (Anticipated)Interventional2022-03-01Not yet recruiting
Assessing Women's Preferences for Postpartum Thromboprophylaxis: the PREFER-PostPartum[NCT05318547]52 participants (Anticipated)Interventional2022-05-13Recruiting
Bemiparin Versus Enoxaparin as Thromboprophylaxis Following Vaginal and Abdominal Deliveries: A Prospective Clinical Trial[NCT01588171]7,020 participants (Actual)Interventional2012-05-31Completed
Low Dose Aspirin and Low-molecular-weight Heparin in the Treatment of Pregnant Libyan Women With Recurrent Miscarriage[NCT01917799]Phase 4150 participants (Anticipated)Interventional2009-01-31Recruiting
Dose Adjusting Enoxaparin Thromboprophylaxis Dosage According to Anti-factor Xa Plasma Levels Improve Pregnancy Outcome[NCT01068795]144 participants (Actual)Interventional2009-07-31Completed
[NCT00319176]15 participants (Anticipated)Observational2004-04-30Completed
anti10a Levels in Women Treated With LMWH in the Postpartum Period for Preventing Vein Thrombosis Events: A Comparison of Two Doses[NCT02856295]Phase 4136 participants (Actual)Interventional2021-11-20Completed
Low-molecular-weight Heparin to Prevent Recurrent VTE in Pregnancy: a Randomized Controlled Trial of Two Doses[NCT01828697]Phase 41,110 participants (Actual)Interventional2013-04-24Completed
Postpartum Prophylaxis for PE Randomized Control Trial Pilot: A Pilot Study Assessing Feasibility of a Randomized, Open-label Trial of Low-Molecular-Weight-Heparin for Postpartum Prophylaxis in Women at Risk of Developing Venous Thromboembolism[NCT01274637]Phase 362 participants (Actual)Interventional2011-03-31Completed
Effects of UFH and LMWH on Osteoprotegerin and RANKL Plasma Levels in Hemodialysis Patients[NCT00669721]40 participants (Anticipated)Interventional2008-03-31Recruiting
Weight-Adjusted Dosing of Tinzaparin in Pregnancy[NCT00851864]Phase 413 participants (Actual)Interventional2007-10-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Death From Venous Thromboembolism

"If a subject dies between randomization and late postpartum follow up (Day 90 +/- 7 days) the death will be adjudicated as certain, highly probable, probable, or unlikely due to Pulmonary Embolism (PE) using the following criteria.~Certain: hypotension, hypoxia, cardiac arrest with no other explanation other than PE and autopsy or radiographic confirmation Highly probable: criteria for certain but another disease could have caused the death Probable: other cause suspected based on clinical evidence but 100% certainty not available Unlikely: all other cases." (NCT01274637)
Timeframe: From Randomization to Day 90

InterventionParticipants (Count of Participants)
Low Molecular Weight Heparin0
Control Group0

Feasibility of Recruitment and Trial Operations.

The average number of subjects that are recruited per site per month during a 4 month active recruitment phase at each site. (NCT01274637)
Timeframe: 4 months

Interventionparticipants per site per month (Number)
Low Molecular Weight Heparin0.9
Control Group0.9

Heparin Induced Thrombocytopenia

All subjects who develop thrombocytopenia (platelets less than 80 x 109/L and/or with >50% decrease from baseline) will be investigated for Heparin Induced Thrombocytopenia (HIT) by having ELISA and serotonin release assays to confirm or refute a diagnosis of HIT. HIT will be diagnosed with a positive PF4 (platelet factor 4) HIT ELISA assay. (NCT01274637)
Timeframe: From Randomization to Day 90

InterventionParticipants (Count of Participants)
Low Molecular Weight Heparin0
Control Group0

Late Symptomatic Venous Thromboembolism

This includes symptomatic Deep Vein Thrombosis or Pulmonary Embolism. Suspected outcomes will be adjudicated by a blinded adjudication committee. (NCT01274637)
Timeframe: From Day 10 to Day 90

InterventionParticipants (Count of Participants)
Low Molecular Weight Heparin0
Control Group0

Major Bleeding or Clinically Relevant Non-major Bleeding

"Major bleeding meets at least one of the following: Fatal bleeding; Symptomatic bleeding in a critical area or organ (intracranial, intraspinal, retroperitoneal, etc.); Bleeding causing a fall in hemoglobin level of 20 g L-1 (1.24 mmol L-1) or more, or leading to transfusion of two or more units of whole blood or red cells .~Clinically Relevant Non-major Bleeding does not meet the criteria for major bleeding but meets at least one of the following: Hospitalization; Medical intervention; Unscheduled contact with a physician; Discomfort (pain, or impairment of activities of daily life)." (NCT01274637)
Timeframe: From Randomization to Day 90

InterventionParticipants (Count of Participants)
Low Molecular Weight Heparin3
Control Group1

Venous Thromboembolism in the Early Postpartum Period.

This includes symptomatic Deep Vein Thrombosis (DVT) or pulmonary embolism (PE) in the interval between randomization and the last dose of study drug (10 days +/- 3 days) OR asymptomatic proximal DVT detected by compression ultrasound of both legs done within 24hrs of the last dose of study drug (10 days (+/- 3 days) postpartum). Compressed and non-compressed images will be obtained from the calf trifurcation to the inguinal ligament. All suspected outcomes will be adjudicated by a blinded expert adjudication committee. (NCT01274637)
Timeframe: From randomization to Day 10

InterventionParticipants (Count of Participants)
Low Molecular Weight Heparin0
Control Group0

Reviews

8 reviews available for dalteparin and Complications, Hematologic Pregnancy

ArticleYear
Aspirin and/or heparin for women with unexplained recurrent miscarriage with or without inherited thrombophilia.
    The Cochrane database of systematic reviews, 2014, Jul-04, Issue:7

    Topics: Abortion, Habitual; Anticoagulants; Antiphospholipid Syndrome; Aspirin; Enoxaparin; Female; Heparin,

2014
Use of the low-molecular-weight heparin nadroparin during pregnancy. A review.
    Current medical research and opinion, 2003, Volume: 19, Issue:1

    Topics: Antiphospholipid Syndrome; Female; Fibrinolytic Agents; Heart Valve Prosthesis; Herpes Simplex; Huma

2003
[Successful prophylaxis in a pregnancy with thrombophilic states].
    Vutreshni bolesti, 1999, Volume: 31, Issue:2-3

    Topics: Acenocoumarol; Adult; Anticoagulants; Drug Therapy, Combination; Female; Gravidity; Humans; Nadropar

1999
Thromboprophylaxis in medical patients: focus on France.
    Seminars in thrombosis and hemostasis, 2002, Volume: 28 Suppl 3

    Topics: Acute Disease; Adult; Aged; Attitude of Health Personnel; Cardiovascular Diseases; Double-Blind Meth

2002
Thrombophilia and pregnancy complications.
    American journal of obstetrics and gynecology, 2004, Volume: 191, Issue:2

    Topics: Abortion, Habitual; Enoxaparin; Factor V; Female; Fetal Growth Retardation; Fibrinolytic Agents; Hum

2004
Gestational thrombocythaemia associated with intrauterine death: case report and a review of the literature.
    Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology, 2006, Volume: 26, Issue:1

    Topics: Anticoagulants; Enoxaparin; Female; Fetal Death; Humans; Placenta; Placenta Diseases; Pregnancy; Pre

2006
Antiphospholipid syndrome in pregnancy.
    Hematology/oncology clinics of North America, 2008, Volume: 22, Issue:1

    Topics: Abortion, Habitual; Antibodies, Antiphospholipid; Anticoagulants; Antiphospholipid Syndrome; Aspirin

2008
Reviparin sodium - a new low molecular weight heparin.
    Expert opinion on pharmacotherapy, 2002, Volume: 3, Issue:2

    Topics: Absorption; Anticoagulants; Child; Drug Evaluation; Factor Xa Inhibitors; Female; Heparin, Low-Molec

2002

Trials

22 trials available for dalteparin and Complications, Hematologic Pregnancy

ArticleYear
Bemiparin versus enoxaparin as thromboprophylaxis following vaginal and abdominal deliveries: a prospective clinical trial.
    BMC pregnancy and childbirth, 2015, Mar-28, Volume: 15

    Topics: Adult; Anticoagulants; Cesarean Section; Enoxaparin; Female; Hematoma; Heparin, Low-Molecular-Weight

2015
Bemiparin versus enoxaparin as thromboprophylaxis following vaginal and abdominal deliveries: a prospective clinical trial.
    BMC pregnancy and childbirth, 2015, Mar-28, Volume: 15

    Topics: Adult; Anticoagulants; Cesarean Section; Enoxaparin; Female; Hematoma; Heparin, Low-Molecular-Weight

2015
Bemiparin versus enoxaparin as thromboprophylaxis following vaginal and abdominal deliveries: a prospective clinical trial.
    BMC pregnancy and childbirth, 2015, Mar-28, Volume: 15

    Topics: Adult; Anticoagulants; Cesarean Section; Enoxaparin; Female; Hematoma; Heparin, Low-Molecular-Weight

2015
Bemiparin versus enoxaparin as thromboprophylaxis following vaginal and abdominal deliveries: a prospective clinical trial.
    BMC pregnancy and childbirth, 2015, Mar-28, Volume: 15

    Topics: Adult; Anticoagulants; Cesarean Section; Enoxaparin; Female; Hematoma; Heparin, Low-Molecular-Weight

2015
Low dose aspirin and low-molecular-weight heparin in the treatment of pregnant Libyan women with recurrent miscarriage.
    BMC research notes, 2014, Jan-09, Volume: 7

    Topics: Abortion, Habitual; Adult; Aspirin; Birth Weight; Embryo Implantation; Enoxaparin; Female; Fibrinoly

2014
Adjusting enoxaparin dosage according to anti-FXa levels and pregnancy outcome in thrombophilic women. A randomised controlled trial.
    Thrombosis and haemostasis, 2016, Sep-27, Volume: 116, Issue:4

    Topics: Adult; Anticoagulants; Birth Weight; Enoxaparin; Factor Xa Inhibitors; Female; Humans; Infant, Newbo

2016
The Prevalence of Thrombophilia in Women With Recurrent Fetal Loss and Outcome of Anticoagulation Therapy for the Prevention of Miscarriages.
    Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis, 2018, Volume: 24, Issue:1

    Topics: Abortion, Habitual; Adolescent; Adult; Anticoagulants; Aspirin; Enoxaparin; Female; Humans; Middle A

2018
Enoxaparin-metformin and enoxaparin alone may safely reduce pregnancy loss.
    Translational research : the journal of laboratory and clinical medicine, 2009, Volume: 153, Issue:1

    Topics: Abortion, Habitual; Abortion, Spontaneous; Adult; Anticoagulants; Blood Coagulation Disorders; Dose-

2009
Influence of long-term thromboprophylaxis with low-molecular-weight heparin (enoxaparin) on changes of bone metabolism markers in pregnant women.
    Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis, 2011, Volume: 17, Issue:5

    Topics: Adult; Alkaline Phosphatase; Anticoagulants; Bone and Bones; Enoxaparin; Female; Gestational Age; Hu

2011
High factor XI, recurrent pregnancy loss, enoxaparin.
    Fertility and sterility, 2010, Volume: 94, Issue:7

    Topics: Abortion, Habitual; Anticoagulants; Cohort Studies; Embryo Loss; Enoxaparin; Factor XI; Female; Homo

2010
Thromboprophylaxis improves the live birth rate in women with consecutive recurrent miscarriages and hereditary thrombophilia.
    Journal of thrombosis and haemostasis : JTH, 2003, Volume: 1, Issue:3

    Topics: Abortion, Habitual; Adult; Birth Rate; Enoxaparin; Family Health; Female; Fibrinolytic Agents; Human

2003
Pregnancy loss, polycystic ovary syndrome, thrombophilia, hypofibrinolysis, enoxaparin, metformin.
    Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis, 2004, Volume: 10, Issue:4

    Topics: Abortion, Habitual; Abortion, Spontaneous; Adult; Blood Coagulation Disorders; Case-Control Studies;

2004
Efficacy and safety of two doses of enoxaparin in women with thrombophilia and recurrent pregnancy loss: the LIVE-ENOX study.
    Journal of thrombosis and haemostasis : JTH, 2005, Volume: 3, Issue:2

    Topics: Abortion, Habitual; Dose-Response Relationship, Drug; Drug Hypersensitivity; Enoxaparin; Female; Hem

2005
Modulation of systemic hemostatic parameters by enoxaparin during gestation in women with thrombophilia and pregnancy loss.
    Thrombosis and haemostasis, 2005, Volume: 94, Issue:5

    Topics: Abortion, Habitual; Adult; Anticoagulants; Enoxaparin; Female; Fibrin Fibrinogen Degradation Product

2005
Changes in enoxaparin pharmacokinetics during pregnancy and implications for antithrombotic therapeutic strategy.
    Clinical pharmacology and therapeutics, 2008, Volume: 84, Issue:3

    Topics: Adult; Anticoagulants; Enoxaparin; Female; Gestational Age; Humans; Metabolic Clearance Rate; Postpa

2008
Use of a low-molecular weight heparin (enoxaparin) or of a phenformin-like substance (moroxydine chloride) in primary early recurrent aborters with an impaired fibrinolytic capacity.
    Thrombosis and haemostasis, 1995, Volume: 73, Issue:3

    Topics: Abortion, Habitual; Adult; Biguanides; Double-Blind Method; Enoxaparin; Female; Fibrinolysis; Humans

1995
Low-molecular-weight heparin to prevent postpartum venous thromboembolism. A pilot randomised placebo-controlled trial.
    Thrombosis and haemostasis, 2015, Volume: 113, Issue:1

    Topics: Adult; Anticoagulants; Dalteparin; Double-Blind Method; Drug Administration Schedule; Feasibility St

2015
The effect of dalteparin on coagulation activation during pregnancy in women with thrombophilia. A randomized trial.
    Thrombosis and haemostasis, 2007, Volume: 98, Issue:1

    Topics: Adult; Anticoagulants; Antithrombin III; Biomarkers; Blood Coagulation; Dalteparin; Female; Heparin,

2007
Long-term dalteparin in pregnancy not associated with a decrease in bone mineral density: substudy of a randomized controlled trial.
    Journal of thrombosis and haemostasis : JTH, 2007, Volume: 5, Issue:8

    Topics: Adult; Anticoagulants; Bone Density; Bone Diseases, Metabolic; Dalteparin; Female; Humans; Middle Ag

2007
Thromboprophylaxis with low molecular mass heparin, 'Fragmin' (dalteparin), during pregnancy--a longitudinal safety study.
    Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 1998, Volume: 9, Issue:1

    Topics: Adult; Dalteparin; Drug Administration Schedule; Female; Humans; Longitudinal Studies; Pregnancy; Pr

1998
Prophylaxis and treatment of thromboembolic diseases during pregnancy with dalteparin.
    International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 2000, Volume: 71, Issue:1

    Topics: Adult; Anticoagulants; Body Mass Index; Body Weight; Dalteparin; Drug Monitoring; Female; Follow-Up

2000
The impact of dalteparin (Fragmin) on thrombin generation in pregnant women with venous thromboembolism: significance of the factor V Leiden mutation.
    Thrombosis and haemostasis, 2001, Volume: 85, Issue:5

    Topics: Adult; Anticoagulants; Case-Control Studies; Dalteparin; Factor V; Female; Hemostasis; Hemostatics;

2001
Increased thromboxane production in women with a history of venous thromboembolic event: effect of heparins.
    British journal of haematology, 2001, Volume: 114, Issue:3

    Topics: 6-Ketoprostaglandin F1 alpha; Adult; Analysis of Variance; Anticoagulants; Body Mass Index; Case-Con

2001
Postpartum bone mineral density in women treated for thromboprophylaxis with unfractionated heparin or LMW heparin.
    Thrombosis and haemostasis, 2002, Volume: 87, Issue:2

    Topics: Absorptiometry, Photon; Adult; Anticoagulants; Bone Density; Dalteparin; Factor Xa Inhibitors; Femal

2002
Weight-adjusted dosing of tinzaparin in pregnancy.
    Thrombosis research, 2013, Volume: 131, Issue:2

    Topics: Adult; Body Weight; Dose-Response Relationship, Drug; Female; Fibrinolytic Agents; Heparin, Low-Mole

2013

Other Studies

54 other studies available for dalteparin and Complications, Hematologic Pregnancy

ArticleYear
Thrombogenesis in Thrombophilic Pregnancy: Evaluation of Low-Molecular-Weight Heparin Prophylaxis.
    Acta haematologica, 2017, Volume: 137, Issue:4

    Topics: Adult; Anticoagulants; Case-Control Studies; Factor Xa Inhibitors; Female; Heparin, Low-Molecular-We

2017
[Successful pregnancy outcome in the woman with thrombophilia and multiple miscarriages].
    Ginekologia polska, 2003, Volume: 74, Issue:5

    Topics: Abortion, Habitual; Adult; Anticoagulants; Aspirin; Cesarean Section; Factor V; Female; Heterozygote

2003
Pregnancy in a woman with a history of Budd-Chiari syndrome treated by porto-systemic shunt, protein C deficiency and bicornuate uterus.
    Thrombosis and haemostasis, 2006, Volume: 95, Issue:6

    Topics: Adult; Anticoagulants; Budd-Chiari Syndrome; Female; Humans; Labor, Induced; Nadroparin; Portasystem

2006
[The use of fraxiparin for the prevention and treatment of thromboembolism in patients with heparin-induced thrombocytopenia].
    Terapevticheskii arkhiv, 1993, Volume: 65, Issue:10

    Topics: Adult; Disseminated Intravascular Coagulation; Drug Evaluation; Female; Heparin; Humans; Male; Middl

1993
[Use of low molecular weight heparins].
    Revista espanola de anestesiologia y reanimacion, 1997, Volume: 44, Issue:2

    Topics: Anesthesia, Epidural; Anesthesia, Obstetrical; Anticoagulants; Antithrombin III Deficiency; Cesarean

1997
[Thrombophilia, anticoagulant therapy and pregnancy].
    Orvosi hetilap, 1998, Dec-27, Volume: 139, Issue:52

    Topics: Adult; Anticoagulants; Female; Heparin, Low-Molecular-Weight; Humans; Maternal Mortality; Nadroparin

1998
Effects of anti-Xa activity monitoring on the outcome of high-risk pregnancies treated with a prophylactic dose of low-molecular-weight heparin.
    European journal of haematology, 2023, Volume: 111, Issue:4

    Topics: Anticoagulants; Enoxaparin; Female; Heparin, Low-Molecular-Weight; Humans; Infant, Newborn; Pregnanc

2023
A prospective cohort study comparing achieved anti-factor Xa peak levels in pregnant and non-pregnant patients receiving therapeutic-dose low-molecular-weight heparin.
    International journal of hematology, 2020, Volume: 112, Issue:1

    Topics: Adult; Anticoagulants; Biomarkers; Body Mass Index; Cohort Studies; Drug Monitoring; Enoxaparin; Fac

2020
Outcomes of threatened abortions after anticoagulation treatment to prevent recurrent pregnancy loss.
    Reproductive biomedicine online, 2017, Volume: 35, Issue:4

    Topics: Abortion, Habitual; Abortion, Threatened; Adult; Anticoagulants; Enoxaparin; Female; Humans; Live Bi

2017
Improvement of maternal and fetal outcomes in women with sickle cell disease treated with early prophylactic erythrocytapheresis.
    Transfusion, 2018, Volume: 58, Issue:9

    Topics: Abortion, Spontaneous; Adult; Anemia, Sickle Cell; Anticoagulants; Birth Weight; Cross-Sectional Stu

2018
Multidisciplinary approach in pregnancy-associated thrombotic thrombocytopenic purpura: a case report.
    Blood transfusion = Trasfusione del sangue, 2014, Volume: 12 Suppl 1

    Topics: Adult; Antibodies, Monoclonal, Murine-Derived; Anticoagulants; Cesarean Section; Combined Modality T

2014
Two successful pregnancies in a carrier of heterozygous factor V LEIDEN mutation with aplasia of the inferior vena cava and a history of proximal deep venous thrombosis.
    Archives of gynecology and obstetrics, 2014, Volume: 289, Issue:6

    Topics: Anticoagulants; Enoxaparin; Factor V; Female; Heterozygote; Humans; Iliac Vein; Live Birth; Mutation

2014
Postpartum osteoporosis and vertebral fractures in two patients treated with enoxaparin during pregnancy.
    Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2015, Volume: 26, Issue:1

    Topics: Absorptiometry, Photon; Adult; Anticoagulants; Bone Density; Enoxaparin; Female; Fractures, Compress

2015
Spontaneous spinal epidural hematoma in pregnancy associated with using low molecular weight heparin.
    Obstetrics and gynecology, 2009, Volume: 113, Issue:2 Pt 2

    Topics: Adult; Anticoagulants; Antiphospholipid Syndrome; Cesarean Section; Enoxaparin; Female; Hematoma, Ep

2009
Treatment of patients with dysfibrinogenemia and a history of abortions during pregnancy.
    Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 2009, Volume: 20, Issue:5

    Topics: Abortion, Habitual; Abruptio Placentae; Adult; Afibrinogenemia; Enoxaparin; Female; Fibrinogen; Fibr

2009
New observations in postpartum ovarian vein thrombosis: experience of single center.
    Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 2010, Volume: 21, Issue:1

    Topics: Adult; Anticoagulants; Aspirin; Cesarean Section; Early Diagnosis; Enoxaparin; Female; Humans; Incid

2010
Fluctuations in anti-factor Xa levels with therapeutic enoxaparin anticoagulation in pregnancy.
    Journal of perinatology : official journal of the California Perinatal Association, 2010, Volume: 30, Issue:4

    Topics: Adult; Cross-Sectional Studies; Drug Administration Schedule; Drug Monitoring; Enoxaparin; Factor Xa

2010
Partial thrombus resolution with trofiban in a pregnant woman with mechanical prosthetic mitral valve thrombosis.
    Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis, 2011, Volume: 17, Issue:5

    Topics: Adult; Echocardiography, Transesophageal; Enoxaparin; Female; Fibrinolytic Agents; Heart Valve Prost

2011
Low molecular weight heparin treatment during subsequent pregnancies of women with inherited thrombophilia and previous severe pregnancy complications.
    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2011, Volume: 24, Issue:8

    Topics: Adult; Anticoagulants; Enoxaparin; Female; Humans; Pregnancy; Pregnancy Complications; Pregnancy Com

2011
Dosing and monitoring of low-molecular-weight heparin in high-risk pregnancy: single-center experience.
    Pharmacotherapy, 2011, Volume: 31, Issue:7

    Topics: Academic Medical Centers; Adult; Anticoagulants; Body Weight; Cohort Studies; Dalteparin; Dose-Respo

2011
Management and adherence to VTE treatment guidelines in a national prospective cohort study in the Canadian outpatient setting. The Recovery Study.
    Thrombosis and haemostasis, 2012, Volume: 108, Issue:3

    Topics: Adult; Aged; Anticoagulants; Canada; Catheterization; Coumarins; Disease Management; Drug Utilizatio

2012
[Usefulness of a scoring system on perinatal outcomes in pregnant women with thrombophilia in the effectiveness of an enoxaparin-based intervention].
    Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia, 2012, Volume: 34, Issue:10

    Topics: Adult; Anticoagulants; Enoxaparin; Female; Humans; Pregnancy; Pregnancy Complications, Hematologic;

2012
Preventing adverse obstetric outcomes in women with genetic thrombophilia.
    Fertility and sterility, 2002, Volume: 78, Issue:2

    Topics: Aspirin; Enoxaparin; Female; Fibrinolytic Agents; Heparin; Humans; Pregnancy; Pregnancy Complication

2002
ACOG Committee Opinion: safety of Lovenox in pregnancy.
    Obstetrics and gynecology, 2002, Volume: 100, Issue:4

    Topics: Anticoagulants; Enoxaparin; Female; Humans; Pregnancy; Pregnancy Complications, Hematologic; Safety

2002
Treatment of acute pulmonary embolism during pregnancy with low molecular weight heparin: three case reports.
    Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 2002, Volume: 13, Issue:7

    Topics: Acute Disease; Adult; Enoxaparin; Female; Heparin, Low-Molecular-Weight; Humans; Pregnancy; Pregnanc

2002
Prosthetic heart valves and pregnancy.
    Circulation, 2003, Dec-09, Volume: 108, Issue:23

    Topics: Abnormalities, Drug-Induced; Anticoagulants; Enoxaparin; Female; Heart Valve Prosthesis; Humans; Pre

2003
Low molecular weight heparin for repeated pregnancy loss: is it based on solid evidence?
    Journal of thrombosis and haemostasis : JTH, 2005, Volume: 3, Issue:2

    Topics: Abortion, Habitual; Clinical Protocols; Clinical Trials as Topic; Enoxaparin; Female; Heparin, Low-M

2005
The long and winding road ... towards LMWH for pregnancy loss.
    Journal of thrombosis and haemostasis : JTH, 2005, Volume: 3, Issue:2

    Topics: Abortion, Habitual; Clinical Protocols; Enoxaparin; Female; Heparin, Low-Molecular-Weight; Humans; P

2005
Thrombophilia and pregnancy loss in first intended pregnancy.
    Journal of thrombosis and haemostasis : JTH, 2005, Volume: 3, Issue:10

    Topics: Abortion, Habitual; Abortion, Spontaneous; Enoxaparin; Female; Gravidity; Humans; Pregnancy; Pregnan

2005
Inherited thrombophilia: treatment during pregnancy.
    Fetal diagnosis and therapy, 2006, Volume: 21, Issue:3

    Topics: Adult; Anticoagulants; Birth Weight; Cesarean Section; Delivery, Obstetric; Enoxaparin; Female; Feta

2006
[Analgesia for childbirth in a patient with factor V Leiden mutation].
    Revista espanola de anestesiologia y reanimacion, 2007, Volume: 54, Issue:1

    Topics: Activated Protein C Resistance; Adult; Analgesia, Epidural; Analgesia, Obstetrical; Anticoagulants;

2007
Antithrombotic prophylaxis during pregnancy in women with deficiency of natural anticoagulants.
    Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 2008, Volume: 19, Issue:3

    Topics: Abortion, Habitual; Adult; Anticoagulants; Cohort Studies; Enoxaparin; Female; Humans; Live Birth; P

2008
Anesthetic management of a parturient with hyperhomocysteinemia.
    Anesthesia and analgesia, 2008, Volume: 106, Issue:6

    Topics: Adult; Anesthesia, Spinal; Anesthetics, Inhalation; Anticoagulants; Blood Coagulation; Blood Coagula

2008
Deep venous thrombosis in a preterm newborn of a mother with activated protein C resistance.
    Clinical pediatrics, 1998, Volume: 37, Issue:6

    Topics: Adult; Blood Coagulation Disorders; Enoxaparin; Female; Humans; Infant, Newborn; Infant, Premature,

1998
Anti-activated factor X profiles in pregnant women receiving antenatal thromboprophylaxis with enoxaparin.
    Acta haematologica, 1999, Volume: 101, Issue:1

    Topics: Adult; Anticoagulants; Enoxaparin; Factor Xa; Female; Humans; Pregnancy; Pregnancy Complications, He

1999
[Resistance to activated protein C and pregnancy: thromboprophylaxis with low molecular weight heparin].
    Journal de gynecologie, obstetrique et biologie de la reproduction, 1999, Volume: 28, Issue:6

    Topics: Activated Protein C Resistance; Adult; Anticoagulants; Enoxaparin; Factor V; Female; Humans; Point M

1999
The effect of thrombophylaxis on pregnancy outcome in patients with recurrent pregnancy loss associated with factor V Leiden mutation.
    BJOG : an international journal of obstetrics and gynaecology, 2000, Volume: 107, Issue:3

    Topics: Abortion, Habitual; Adult; Anticoagulants; Aspirin; Drug Therapy, Combination; Enoxaparin; Factor V;

2000
Gestational outcome in thrombophilic women with recurrent pregnancy loss treated by enoxaparin.
    Thrombosis and haemostasis, 2000, Volume: 83, Issue:5

    Topics: 3' Untranslated Regions; Abortion, Habitual; Activated Protein C Resistance; Adult; Anticoagulants;

2000
Bleeding complications associated with low molecular weight heparin prophylaxis during pregnancy.
    Thrombosis and haemostasis, 2000, Volume: 84, Issue:1

    Topics: Anemia; Anticoagulants; Dalteparin; Delivery, Obstetric; Dextrans; Enoxaparin; Female; Hemorrhage; H

2000
A complication in anticoagulation using low-molecular weight heparin in a patient with a mechanical valve prosthesis. A case report.
    The Journal of heart valve disease, 2000, Volume: 9, Issue:6

    Topics: Adult; Anticoagulants; Dilatation and Curettage; Enoxaparin; Female; Heart Valve Prosthesis; Heart V

2000
Venous thromboembolism during pregnancy: a retrospective study of enoxaparin safety in 624 pregnancies.
    BJOG : an international journal of obstetrics and gynaecology, 2001, Volume: 108, Issue:11

    Topics: Adult; Anticoagulants; Cerebral Hemorrhage; Enoxaparin; Female; Humans; Infant, Newborn; Intracrania

2001
Recurrent cerebral ischaemia in a pregnant woman with patent foramen ovale II° and thrombophilia.
    Hamostaseologie, 2014, Volume: 34, Issue:3

    Topics: Adult; Anticoagulants; Brain Ischemia; Dalteparin; Female; Foramen Ovale, Patent; Humans; Injections

2014
A prospective analysis of heparin-platelet factor 4 antibodies in pregnant women treated with the low-molecular-weight heparin, dalteparin.
    Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 2008, Volume: 19, Issue:6

    Topics: Adult; Antibody Specificity; Antigens, Human Platelet; Autoantibodies; Autoantigens; Dalteparin; Dos

2008
The effect of low molecular weight heparin (dalteparin) on duration and initiation of labour.
    Journal of thrombosis and thrombolysis, 2010, Volume: 30, Issue:2

    Topics: Adult; Anticoagulants; Case-Control Studies; Chi-Square Distribution; Dalteparin; Female; Gestationa

2010
Treatment of deep venous thrombosis with low-molecular-weight heparin during pregnancy.
    Thrombosis research, 2002, Apr-01, Volume: 106, Issue:1

    Topics: Adult; Dalteparin; Drug Evaluation; Female; Hemorrhage; Heparin; Heparin, Low-Molecular-Weight; Huma

2002
Dalteparin and low-dose aspirin in the prevention of adverse obstetric outcomes in women with inherited thrombophilia.
    Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC, 2007, Volume: 29, Issue:10

    Topics: Abruptio Placentae; Adult; Anticoagulants; Aspirin; Dalteparin; Drug Therapy, Combination; Female; F

2007
Thromboprophylaxis with low molecular weight heparin (Fragmin) in high risk pregnancies.
    Thrombosis and haemostasis, 1997, Volume: 77, Issue:1

    Topics: Adult; Anticoagulants; Dalteparin; Female; Humans; Injections, Subcutaneous; Pregnancy; Pregnancy Co

1997
[Does the pork/cat syndrome constitute a predisposition to heparin allergy?].
    Allergie et immunologie, 1997, Volume: 29, Issue:2

    Topics: Adult; Allergens; Animals; Asthma; Blotting, Western; Cats; Cross Reactions; Dalteparin; Drug Erupti

1997
Successful use of heparinoids in a pregnancy complicated by allergy to heparin.
    BJOG : an international journal of obstetrics and gynaecology, 2001, Volume: 108, Issue:9

    Topics: Adult; Anticoagulants; Chondroitin Sulfates; Dalteparin; Dermatan Sulfate; Drug Combinations; Drug H

2001
The assay of overall haemostasis potential used to monitor the low molecular mass (weight) heparin, dalteparin, treatment in pregnant women with previous thromboembolism.
    Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 2002, Volume: 13, Issue:3

    Topics: Adult; Anticoagulants; Biomarkers; Blood Coagulation Tests; Dalteparin; Factor Xa Inhibitors; Female

2002
Tinzaparin safety and efficacy in pregnancy.
    Irish journal of medical science, 2014, Volume: 183, Issue:2

    Topics: Abortion, Habitual; Adolescent; Adult; Drug Hypersensitivity; Female; Fibrinolytic Agents; Hemorrhag

2014
Efficacy and safety of once daily low molecular weight heparin (tinzaparin sodium) in high risk pregnancy.
    Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 2008, Volume: 19, Issue:7

    Topics: Adult; Cohort Studies; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Fibri

2008
Tinzaparin failure in a pregnant patient with a mitral metal valve.
    Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology, 2008, Volume: 28, Issue:5

    Topics: Adult; Female; Fibrinolytic Agents; Heart Valve Prosthesis; Heparin, Low-Molecular-Weight; Humans; P

2008
Aplasia cutis congenita and low molecular weight heparin.
    BJOG : an international journal of obstetrics and gynaecology, 2005, Volume: 112, Issue:2

    Topics: Abnormalities, Drug-Induced; Adult; Ectodermal Dysplasia; Female; Fibrinolytic Agents; Heparin, Low-

2005