Page last updated: 2024-10-18

dalteparin and Colorectal Neoplasms

dalteparin has been researched along with Colorectal Neoplasms in 16 studies

Dalteparin: A low-molecular-weight fragment of heparin, prepared by nitrous acid depolymerization of porcine mucosal heparin. The mean molecular weight is 4000-6000 daltons. It is used therapeutically as an antithrombotic agent. (From Merck Index, 11th ed)

Colorectal Neoplasms: Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.

Research Excerpts

ExcerptRelevanceReference
"Proximal deep vein thrombosis and/or pulmonary embolism occurred in seven patients (3·4 per cent) in the IPC group and one patient (0·5 per cent) in the IPC with enoxaparin group (P = 0·050)."2.94Intermittent pneumatic compression versus additional prophylaxis with enoxaparin for prevention of venous thromboembolism after laparoscopic surgery for gastric and colorectal malignancies: multicentre randomized clinical trial. ( Amano, T; Funakoshi, T; Homma, S; Ichikawa, N; Kamachi, H; Kawamura, H; Maeda, Y; Ohno, Y; Takahashi, N; Taketomi, A; Yokota, R; Yoshida, T, 2020)
"Patients with liver metastases from colorectal carcinoma who were scheduled for local ablation by radiotherapy (image-guided high-dose-rate interstitial brachytherapy) were prospectively randomized to receive PTX, UDCA and LMWH for 8 weeks (treatment) or no medication (control)."2.79Prospective randomized trial of enoxaparin, pentoxifylline and ursodeoxycholic acid for prevention of radiation-induced liver toxicity. ( Damm, R; Gademann, G; Hass, P; Kropf, S; Mohnike, K; Pech, M; Ricke, J; Sangro, B; Seidensticker, M; Seidensticker, R; Wust, P, 2014)
"The optimal thromboprophylactic dosage regimen of low-molecular-weight heparins in high-risk general surgery remains debatable."2.72A randomized study comparing the efficacy and safety of nadroparin 2850 IU (0.3 mL) vs. enoxaparin 4000 IU (40 mg) in the prevention of venous thromboembolism after colorectal surgery for cancer. ( Bergman, JF; Derlon, A; Laporte, S; Mismetti, P; Samama, CM; Samii, K; Simonneau, G, 2006)
"HT29 human colorectal cancers were implanted in dorsal skinfold window chambers in athymic mice."1.42Microvascular effects of the low molecular weight heparins in a colorectal xenograft model: an intravital microscopy study. ( Ceelen, W; Debergh, I; Pattyn, P, 2015)
"Patients undergoing elective colorectal cancer surgery from 2007 to 2009 at the Royal Adelaide and Queen Elizabeth hospitals were identified from a prospective database."1.39Is extended thromboprophylaxis necessary in elective colorectal cancer surgery? ( Chandra, R; Hunter, RA; Lawrence, MJ; Melino, G; Moore, J; Thomas, M, 2013)

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (18.75)29.6817
2010's8 (50.00)24.3611
2020's5 (31.25)2.80

Authors

AuthorsStudies
Debergh, I1
Pattyn, P1
Ceelen, W1
Simonneau, G1
Laporte, S1
Mismetti, P1
Derlon, A1
Samii, K1
Samama, CM1
Bergman, JF1
Lobastov, K1
Dementieva, G1
Soshitova, N1
Bargandzhiya, A1
Barinov, V1
Laberko, L1
Rodoman, G1
Kamachi, H1
Homma, S1
Kawamura, H1
Yoshida, T1
Ohno, Y1
Ichikawa, N1
Yokota, R1
Funakoshi, T1
Maeda, Y1
Takahashi, N1
Amano, T1
Taketomi, A1
Yamashita, S1
Nishi, M1
Ikemoto, T1
Yoshikawa, K1
Higashijima, J1
Tokunaga, T1
Takasu, C1
Kashihara, H1
Eto, S1
Yoshimoto, T1
Shimada, M1
Ohta, H1
Miyake, T1
Shimizu, T1
Sonoda, H1
Ueki, T1
Kaida, S1
Yamaguchi, T1
Iida, H1
Tani, M1
Nakagawa, K1
Watanabe, J1
Ota, M1
Suwa, Y1
Suzuki, S1
Suwa, H1
Momiyama, M1
Ishibe, A1
Saigusa, Y1
Yamanaka, T1
Kunisaki, C1
Endo, I1
Chandra, R1
Melino, G1
Thomas, M1
Lawrence, MJ1
Hunter, RA1
Moore, J1
Seidensticker, M1
Seidensticker, R1
Damm, R1
Mohnike, K1
Pech, M1
Sangro, B1
Hass, P1
Wust, P1
Kropf, S1
Gademann, G1
Ricke, J1
Giuliani, J1
Martelli, S1
Piacentini, P1
Bonetti, A1
Stamenkovic, DM1
Jankovic, ZB1
Toogood, GJ1
Lodge, JP1
Bellamy, MC1
Varpe, P1
Huhtinen, H1
Rantala, A1
Grönroos, J1
Ma, L1
Qiao, H1
He, C1
Yang, Q1
Cheung, CH1
Kanwar, JR1
Sun, X1
Brzezková, R1
Frýba, V1
Chrz, K1
Krska, Z1
Kvasnicka, J1
Auer, RC1
Ott, M1
Karanicolas, P1
Brackstone, MR1
Ashamalla, S1
Weaver, J1
Tagalakis, V1
Boutros, M1
Stotland, P1
Marulanda, AC1
Moloo, H1
Jayaraman, S1
Patel, S1
Le Gal, G1
Spadafora, S1
MacLellan, S1
Trottier, D1
Jonker, D1
Asmis, T1
Mallick, R1
Pecarskie, A1
Ramsay, T1
Carrier, M1
Gamperl, H1
Plattfaut, C1
Freund, A1
Quecke, T1
Theophil, F1
Gieseler, F1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Evaluation of the Preventive Effect of Enoxaparin, Pentoxifylline and Ursodeoxycholic Acid to Radiation Induced Liver Toxicity After Brachytherapy of Liver Metastases From Colorectal Carcinoma, Assessed in a Prospective Randomised Trial[NCT01149304]Phase 222 participants (Actual)Interventional2009-06-30Completed
Analgesic and Hemodynamic Effects of Continuous Epidural Analgesia Compared to Paravertebral Block in Liver Resection Patients[NCT02909322]Phase 450 participants (Anticipated)Interventional2016-04-30Recruiting
A Multicentre Randomized Controlled Trial of the Use of Extended Peri-Operative Low Molecular Weight Heparin to Improve Cancer Specific Survival Following Surgical Resection of Colorectal Cancer[NCT01455831]Phase 3616 participants (Actual)Interventional2011-09-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

5 trials available for dalteparin and Colorectal Neoplasms

ArticleYear
A randomized study comparing the efficacy and safety of nadroparin 2850 IU (0.3 mL) vs. enoxaparin 4000 IU (40 mg) in the prevention of venous thromboembolism after colorectal surgery for cancer.
    Journal of thrombosis and haemostasis : JTH, 2006, Volume: 4, Issue:8

    Topics: Adult; Aged; Aged, 80 and over; Anticoagulants; Colorectal Neoplasms; Enoxaparin; Female; Fibrinolyt

2006
Intermittent pneumatic compression versus additional prophylaxis with enoxaparin for prevention of venous thromboembolism after laparoscopic surgery for gastric and colorectal malignancies: multicentre randomized clinical trial.
    BJS open, 2020, Volume: 4, Issue:5

    Topics: Aged; Anticoagulants; Colorectal Neoplasms; Enoxaparin; Female; Hemorrhage; Humans; Intermittent Pne

2020
Efficacy and safety of enoxaparin for preventing venous thromboembolic events after laparoscopic colorectal cancer surgery: a randomized-controlled trial (YCOG 1404).
    Surgery today, 2020, Volume: 50, Issue:1

    Topics: Adult; Aged; Anticoagulants; Colorectal Neoplasms; Digestive System Surgical Procedures; Enoxaparin;

2020
Prospective randomized trial of enoxaparin, pentoxifylline and ursodeoxycholic acid for prevention of radiation-induced liver toxicity.
    PloS one, 2014, Volume: 9, Issue:11

    Topics: Aged; Aged, 80 and over; Brachytherapy; Colorectal Neoplasms; Enoxaparin; Female; Humans; Liver Neop

2014
Efficacy and safety of extended duration to perioperative thromboprophylaxis with low molecular weight heparin on disease-free survival after surgical resection of colorectal cancer (PERIOP-01): multicentre, open label, randomised controlled trial.
    BMJ (Clinical research ed.), 2022, 09-13, Volume: 378

    Topics: Adolescent; Adult; Anticoagulants; Colorectal Neoplasms; Disease-Free Survival; Heparin, Low-Molecul

2022

Other Studies

11 other studies available for dalteparin and Colorectal Neoplasms

ArticleYear
Microvascular effects of the low molecular weight heparins in a colorectal xenograft model: an intravital microscopy study.
    The Journal of surgical research, 2015, Volume: 194, Issue:2

    Topics: Adenocarcinoma; Animals; Anticoagulants; Colorectal Neoplasms; Enoxaparin; HT29 Cells; Humans; Immun

2015
Utilization of the Caprini score in conjunction with thrombodynamic testing reduces the number of unpredicted postoperative venous thromboembolism events in patients with colorectal cancer.
    Journal of vascular surgery. Venous and lymphatic disorders, 2020, Volume: 8, Issue:1

    Topics: Aged; Aged, 80 and over; Anticoagulants; Blood Coagulation; Blood Coagulation Tests; Colorectal Neop

2020
Clinical analysis of postoperative venous thromboembolism in Japanese patients after colorectal cancer surgery.
    Surgery today, 2021, Volume: 51, Issue:6

    Topics: Aged; Anticoagulants; Asian People; Colorectal Neoplasms; Enoxaparin; Female; Fibrin Fibrinogen Degr

2021
The impact of pharmacological thromboprophylaxis and disease-stage on postoperative bleeding following colorectal cancer surgery.
    World journal of surgical oncology, 2019, Jun-27, Volume: 17, Issue:1

    Topics: Aged; Anticoagulants; Colorectal Neoplasms; Disease Progression; Elective Surgical Procedures; Enoxa

2019
Is extended thromboprophylaxis necessary in elective colorectal cancer surgery?
    ANZ journal of surgery, 2013, Volume: 83, Issue:12

    Topics: Aged; Anticoagulants; Australia; Clinical Protocols; Colorectal Neoplasms; Cost-Benefit Analysis; El

2013
Thromboembolic disease in advanced colorectal cancer treated with chemotherapy and bevacizumab: a case of real "pan-thrombosis".
    Tumori, 2015, Mar-20, Volume: 101, Issue:1

    Topics: Angiogenesis Inhibitors; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Pro

2015
Epidural analgesia and liver resection: postoperative coagulation disorders and epidural catheter removal.
    Minerva anestesiologica, 2011, Volume: 77, Issue:7

    Topics: Aged; Analgesia, Epidural; Anticoagulants; Blood Coagulation Disorders; Blood Transfusion; Catheteri

2011
Thromboprophylaxis following surgery for colorectal cancer - is it worthwhile after hospital discharge?
    Scandinavian journal of surgery : SJS : official organ for the Finnish Surgical Society and the Scandinavian Surgical Society, 2009, Volume: 98, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Anticoagulants; Colorectal Neoplasms; Enoxaparin; Humans; Length of

2009
Modulating the interaction of CXCR4 and CXCL12 by low-molecular-weight heparin inhibits hepatic metastasis of colon cancer.
    Investigational new drugs, 2012, Volume: 30, Issue:2

    Topics: Animals; Antineoplastic Agents; Cell Adhesion; Cell Movement; Cell Proliferation; Chemokine CXCL12;

2012
[Prolonged prophylaxis of thromboembolic disease in patients with colorectal surgical resections for malignancy].
    Rozhledy v chirurgii : mesicnik Ceskoslovenske chirurgicke spolecnosti, 2009, Volume: 88, Issue:11

    Topics: Anticoagulants; Colorectal Neoplasms; Dalteparin; Female; Humans; Male; Middle Aged; Postoperative C

2009
Extracellular vesicles from malignant effusions induce tumor cell migration: inhibitory effect of LMWH tinzaparin.
    Cell biology international, 2016, Volume: 40, Issue:10

    Topics: Breast Neoplasms; Cell Line, Tumor; Cell Movement; Colorectal Neoplasms; Endothelium, Vascular; Epit

2016