dakh-peptide and Hyperglycemia

dakh-peptide has been researched along with Hyperglycemia* in 1 studies

Other Studies

1 other study(ies) available for dakh-peptide and Hyperglycemia

ArticleYear
Midgut-Derived Activin Regulates Glucagon-like Action in the Fat Body and Glycemic Control.
    Cell metabolism, 2017, 02-07, Volume: 25, Issue:2

    While high-caloric diet impairs insulin response to cause hyperglycemia, whether and how counter-regulatory hormones are modulated by high-caloric diet is largely unknown. We find that enhanced response of Drosophila adipokinetic hormone (AKH, the glucagon homolog) in the fat body is essential for hyperglycemia associated with a chronic high-sugar diet. We show that the activin type I receptor Baboon (Babo) autonomously increases AKH signaling without affecting insulin signaling in the fat body via, at least, increase of Akh receptor (AkhR) expression. Further, we demonstrate that Activin-β (Actβ), an activin ligand predominantly produced in the enteroendocrine cells (EEs) of the midgut, is upregulated by chronic high-sugar diet and signals through Babo to promote AKH action in the fat body, leading to hyperglycemia. Importantly, activin signaling in mouse primary hepatocytes also increases glucagon response and glucagon-induced glucose production, indicating a conserved role for activin in enhancing AKH/glucagon signaling and glycemic control.

    Topics: Activin Receptors; Activins; Animals; Carbohydrate Metabolism; Carrier Proteins; Dietary Carbohydrates; Disease Models, Animal; Drosophila melanogaster; Drosophila Proteins; Enteroendocrine Cells; Fat Body; Gastrointestinal Tract; Glucagon; Hepatocytes; Hyperglycemia; Insect Hormones; Larva; Mice; Oligopeptides; Pyrrolidonecarboxylic Acid; Receptors, Glucagon; RNA Interference; RNA, Messenger; Signal Transduction

2017