dactinomycin has been researched along with Melanoma in 196 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 122 (62.24) | 18.7374 |
| 1990's | 18 (9.18) | 18.2507 |
| 2000's | 33 (16.84) | 29.6817 |
| 2010's | 21 (10.71) | 24.3611 |
| 2020's | 2 (1.02) | 2.80 |
| Authors | Studies |
|---|---|
| Atherton, E; Kondo, M; Meienhofer, J; Moore, S; Patel, RP | 1 |
| Almassian, B; Rosenbaum, DP; Sehgal, RK; Sengupta, SK; Zadrozny, R | 2 |
| Almassian, B; Blondin, J; Rosenbaum, DP; Sehgal, RK; Sengupta, SK | 1 |
| Dorr, RT; Hajicek, N; Kalaitzis, JA; Lambert, JD; Meyers, RO; Pourpak, A | 1 |
| Barbour, A; Beasley, GM; Carr, M; Coventry, BJ; Daou, H; Delman, KA; Farley, CR; Farma, JM; Farrow, NE; Henderson, MA; Kenyon-Smith, T; Kroon, HM; Lowe, MC; Miura, JT; Mosca, PJ; Mullen, D; Potdar, A; Serpell, J; Smithers, BM; Speakman, D; Sun, J; Teras, J; Thompson, JF; Tyler, DS; Zager, JS | 1 |
| Barbour, A; Beasley, GM; Coventry, BJ; Daou, H; Delman, KA; Farley, CR; Farma, JM; Farrow, NE; Henderson, MA; Kenyon-Smith, TJ; Kroon, HM; Lowe, MC; Miura, JT; Mosca, PJ; Mullen, D; Potdar, A; Serpell, J; Smithers, BM; Speakman, D; Sun, J; Teras, J; Thompson, JF; Tyler, DS; Zager, JS | 1 |
| Chi, Z; Cui, C; Guo, J; Kong, Y; Li, S; Lian, B; Mao, L; Sheng, X; Si, L; Tang, B; Wang, X; Yan, X | 1 |
| Barbour, A; Coventry, BJ; Henderson, MA; Kroon, HM; Serpell, J; Smithers, BM; Thompson, JF | 1 |
| Beasley, GM; Chen, YA; Fisher, KJ; Tyler, DS; Wong, J; Zager, JS | 1 |
| Ariyan, C; Brady, MS; Rafferty, B; Steinman, J | 1 |
| Huismans, AM; Kam, PC; Kroon, HM; Thompson, JF | 2 |
| Pittayapongpat, R; Pukrushpan, P; Tulvatana, W | 1 |
| Beasley, GM; Lee, JH; Muilenburg, DJ; Thompson, ZJ; Tyler, DS; Zager, JS | 1 |
| Gdowicz-Kłosok, A; Krześniak, M; Rusin, M; Ścieglińska, D; Zajkowicz, A | 1 |
| Bashir, MR; Beasley, GM; Bhatti, L; Brys, AK; Jaffe, TA; Mosca, PJ; Nath, NS; Salama, AK; Tyler, DS | 1 |
| Barbour, A; Coventry, AG; Coventry, BJ; Giles, MH; Henderson, MA; Kroon, HM; Paddle, P; Serpell, J; Smithers, BM; Speakman, D; Sullivan, T; Thompson, JF; Wall, M | 1 |
| Ben-Shabat, I; Dossett, LA; Olofsson Bagge, R; Zager, JS | 1 |
| Kam, PC; Kroon, HM; Moncrieff, M; Thompson, JF | 2 |
| Aloia, T; Beasley, GM; Cheng, TY; McMahon, N; Petersen, RP; Petros, W; Pruitt, SK; Sanders, G; Seigler, H; Tyler, DS; Yoo, J | 1 |
| Bloethner, S; Hayward, NK; Mould, A; Stark, M | 1 |
| Dunleavey, R; Gallagher, SJ; Gao, BF; Indsto, J; Kefford, RF; Lett, M; Mann, GJ; Rizos, H; Scurr, LL; Thompson, JF | 1 |
| Kam, PC; Kroon, HM; Lin, DY; Thompson, JF | 2 |
| Brady, MS; Brown, K; Fisher, C; Marx, W; Patel, A | 2 |
| Andtbacka, RH; Beasley, GM; Caudle, A; Delman, KA; Grobmyer, SR; Hochwald, SN; Kane, JM; McMahon, NS; Mosca, PJ; Noyes, RD; Padussis, J; Petersen, RP; Pruitt, SK; Ross, MI; Seigler, H; Tyler, DS; Zager, JS | 1 |
| Chang, JW; Chang, NJ; Chen, JS; Chen, YR; Chuang, CK; Ho, E; Hou, MM; Hsieh, JJ; Leong, SP; Liao, SK; Shen, YC; Wang, CH | 1 |
| Boesch, CE; Goehl, J; Hohenberger, W; Knorr, C; Merkel, S; Meyer, T; Waschke, L | 1 |
| Kam, PC; Thompson, JF | 1 |
| Clark, TD; Copeland, EM; Filichia, L; Grobmyer, SR; Hochwald, SN; Robinson, AR; Vaughn, K | 1 |
| Abbe, P; Ballotti, R; Deckert, M; Fenouille, N; Mallavialle, A; Ortonne, JP; Puissant, A; Rocchi, S; Tartare-Deckert, S; Tichet, M; Zimniak, G | 1 |
| Belli, AM; Chun, JY; Hussain, M; Powell, B | 1 |
| Beasley, GM; Chai, CY; Chen, YA; Deneve, JL; Grobmyer, SR; Hochwald, SN; Marzban, SS; Rawal, B; Tyler, DS; Zager, JS | 1 |
| Ahmad, SA; Giglia, JS; McClaine, RJ; McCoy, SJ; Sussman, JJ | 1 |
| Beasley, G; Broadwater, G; Mosca, P; Peterson, B; Raymond, AK; Sharma, K; Turley, R; Tyler, D | 1 |
| Belfort, FA; Costa, OF; Duprat Neto, JP; Facure, L; Fregnani, JH; Mauro, AC; Molina, AS; Nishinari, K; Zurstrassen, CE | 1 |
| Fei, XF; Ikejima, T; Li, TJ; Minami, M; Tashiro, S; Wang, BX; Xing, DJ | 1 |
| Bergstralh, DT; Clements, C; MacKeigan, JP; Taxman, DJ; Ting, JP | 1 |
| JOHNSTON, ID | 1 |
| VIGI, F | 1 |
| COBB, JP; WALKER, DG | 1 |
| AKOPYANTS, SS; BELOVA, ZN; EBERT, MK; GOSHEVA, AE; GRACHEVA, NP; KHARITONOVA, AM; PLANELLES, JJ; SILAEV, AB; SOLOVYEVA, YV | 1 |
| DIPAOLO, JA; DOWD, JE; WATNE, AL | 1 |
| ROCHLIN, DB; SMART, CR | 1 |
| TIMOFEEVSKAIA, EA | 1 |
| Isobe, T; Kato, Y; Koga, M; Mizuguchi, J; Saito, M; Shibuya, H; Toyota, H; Tsuboi, R | 1 |
| Fujii, Y; Irimajiri, K; Kinoshita-Kimoto, S; Kotani, M; Nishida, S; Tomura, TT; Tsubaki, M; Yoshioka, S | 1 |
| Borrow, JM; Hersey, P; Nguyen, T; Zhang, XD; Zhang, XY | 1 |
| Homma, T; Nagata, H; Takekoshi, S; Takeyama, R; Yoshiyuki Osamura, R | 1 |
| Goehl, J; Hohenberger, W; Janssen, T; Knorr, C; Meyer, T | 1 |
| Abreu, HF; Burnier, MN; Cardinalli, IA; Isaac, CR; Ober, MD; Odashiro, AN; Palazzi, MA | 1 |
| Bera, R; Bhadra, R; Datta, PK; Mandal, SK; Ratha, J; Saha, B; Sarkar, C; Singh, SK | 1 |
| Alizadeh, H; Li, H; Neelam, S; Niederkorn, JY | 1 |
| Boven, E; Broxterman, HJ; Duyndam, MC; Fontijn, D; Pinedo, HM; Shapiro, LH; van Berkel, MP; Yuana, Y | 1 |
| Bera, R; Bhadra, R; Mallick, S; Saha, B; Sarkar, C; Singh, SK | 1 |
| Hill, AD; Ryan, ER; Skehan, SJ | 1 |
| Kam, PC; Sanki, A; Thompson, JF | 1 |
| Hills, WJ; Rufino, C; Stehlin, JS | 1 |
| Golomb, FM; Gumport, SL; Postel, A; Solowey, AC; Wright, JC | 1 |
| Meyskens, FL; Russell, DH; Scott, KF | 1 |
| Kline, EL; Montefiori, DC | 1 |
| Bychkov, MB; Perevodchikova, NI | 1 |
| Hickie, RA; Meyskens, FL; Sipes, NJ; Thomson, SP | 1 |
| Al-Sarraf, M; Balcerzak, SP; Costanzi, JJ; Eyre, HJ; Fletcher, WS; Frank, J; O'Bryan, RM; Taylor, S | 1 |
| Hendrix, MJ | 1 |
| Ghelelovitch, S | 1 |
| Bomirski, A; Scisłowski, PW; Słomiński, A; Zołnierowicz, S | 1 |
| Baker, LH; Bhathena, DB; Cummings, G; McDonald, B; Samson, MK; Talley, RW | 1 |
| Gehlsen, KR; Hendrix, MJ; Meyskens, FL; Persky, B; Peters, EM; Sorrentino, JM | 1 |
| Salmon, SE | 1 |
| Iavorskiĭ, VV; Musatov, VK; Nivinskaia, MM; Ogurtsova, IN | 1 |
| de Ipolyi, PD; Giovanella, BC; Greeff, PJ; Gutierrez, AE; Stehlin, JS | 1 |
| Orita, K | 1 |
| Fisch, H; Gifford, GE | 1 |
| Aigner, K; Hild, P; Hundeiker, M | 1 |
| Borisov, AI; Kogoniia, LM; Moroz, LV; Perevodchikova, NI; Platinskiĭ, LV | 1 |
| Bodey, GP; Gutterman, JU; Hersh, EM; Robidoux, A | 1 |
| Ewing, JH; Kanter, PM; Karakousis, CP; Moore, R; Park, HC; Sharma, SD | 1 |
| Koops, HS; Martijn, H; Oldhoff, J | 1 |
| Richie, JP | 1 |
| Casey, WJ; Chen, HS; Dana, B; Franks, DH; Gilmartin, E; Meyskens, FL; Moon, TE; Salmon, SE; Young, L | 1 |
| Martijn, H; Oldhoff, J; Schraffordt Koops, H | 1 |
| de Vries, EG; Koops, HS; Mulder, NH; Sleijfer, DT; van der Graaf, WT; Willemse, PH | 1 |
| Edwards, MJ; Polk, HC; Quinn, TD | 1 |
| Collins, KI; Greenberger, LM; Zhang, X | 1 |
| Bos, G; Brown, D; Fletcher, WS; Lebredo, L; Moseley, HS; Small, K; Woltering, EA | 1 |
| Behrens, CH; Behrens, DL; Chen, SF; Fredericks, JR; Kirshenbaum, MR; Papp, LM; Polkus, ST; Sipple, P; Stafford, MM; Sun, JH | 1 |
| Blumenson, L; Karakousis, C | 1 |
| Bergeron, RJ; Fogel-Petrovic, M; Porter, CW; Shappell, NW | 1 |
| Kononuchenko, VP; Litovka, VK; Zhurilo, IP | 1 |
| Krasivs'kiĭ, EZ; Podil'chak, MD; Raspertov, VO; Serbin, VV | 1 |
| Adamis, AP; Amano, S; Beerepoot, LV; Colby, KA; Kim, RY; Kuroki, M; Rohan, RM; Takashima, S; Tolentino, M; Voest, EE; Yeo, KT | 1 |
| Fidler, IJ; Gutman, M; Llansa, N; Singh, RK | 1 |
| Hunt, JA; Kam, PC; Shannon, KF; Thompson, JF | 1 |
| Fang, D; Setaluri, V | 1 |
| Faddis, D; Fried, SJ; Miller, R; Weaver, FA | 1 |
| Ivanov, VN; Ronai, Z | 1 |
| Dent, P; Fisher, PB; Madireddi, MT | 1 |
| Eleftheriou, A; Henderson, BR | 1 |
| El-Deiry, WS; Meng, RD | 1 |
| Fodstad, O; Ivanov, VN; Ronai, Z | 1 |
| Ainslie, J; Finkelde, D; Henderson, MA; McKenzie, A; Mian, R; Speakman, D | 1 |
| Fujimoto, K; Kato, Y; Kawamoto, T; Makihira, S; Noshiro, M; Shen, M; Teramoto, M; Yan, W | 1 |
| Daly, JM; Evoy, DA; Hill, AD; Mack, VE; McCarter, MD; Naama, HA; Shou, J | 1 |
| Mattern, J; Volm, M; Wayss, K | 1 |
| Cohen, SC; Gabelnick, HL; Goldin, A; Johnson, RK | 1 |
| Dickson, JA | 1 |
| Faufmann, M; MAttern, J; Volm, M; Wayss, K | 1 |
| Acs, G; Christman, J; Kyner, D; Newcomb, EW; Silagi, S; Silverstein, SC | 1 |
| Cooper, MR; Muss, HB; Ramseur, WL; Rhyne, L; Richards, F; Spurr, CL; Stuart, JJ; White, DR | 1 |
| Baker, LH; Fraile, RJ; McDonald, B; Samson, MK; Talley, RW | 1 |
| Gotlib, VIa; Nivinskaia, MM; Pelevina, II | 1 |
| Cuttner, J; De Bellis, R; Green, M; Kostinas, JE; Leone, LA; Pajak, TF; Vinciguerra, V | 1 |
| Benjamin, RS; Hall, SW; Lewinski, U; Mavligit, G | 1 |
| Bienkowski, M; Dunn, JR; Honn, KV; Marnett, LJ; Morgan, LR | 1 |
| Kolarić, K; Malenica, B; Roth, A | 1 |
| Benjamin, RS; Mavligit, GM; McBride, CM; Pritchard, JD; Wallace, S | 1 |
| Legha, S; McCredie, KB; Spitzer, G; Verma, DS | 1 |
| Kasai, M; Kuriya, Y; Mori, S; Nishihira, T; Watanabe, T | 1 |
| Banz, H; Groitl, H; Hermanek, P; Tonak, J | 1 |
| Assekritova, IV; Brazhnikova, EI; Moroz, LV; Vaarik, KhM; Voznyĭ, EK | 1 |
| Hunter, JA | 1 |
| Pawelek, J; Wong, G | 2 |
| Copeland, M; Kondo, M; Meienhofer, J; Moore, S | 1 |
| Dämianova, M; Stoychkov, J | 1 |
| Beretta, G; Bonadonna, G; Cascinelli, N; Morabito, A; Veronesi, U | 1 |
| Dengupta, SK; Frei, E; Modest, EJ; Sodergren, JE; Tattersall, MH; Trites, DH | 1 |
| Eidemiller, LR; Fletcher, WS; Yeager, RA | 1 |
| Luce, JK | 1 |
| Goldstein, G; Hugh, GS; Parker, FP | 1 |
| Benjamin, RS; Blumenschein, GR; Burgess, MA; Gottlieb, JA; Hall, SW; Murphy, WK; Wheeler, WL | 1 |
| Kovaleva, VL; Malenkova, EN; Sobol', IL; Sviatukhin, MV | 1 |
| Rangnekar, VM; Rangnekar, VV; Waheed, S | 1 |
| Caliendo, A; Falciani, F; Gaboli, M; Garattini, E; Landolfo, S; Lembo, D | 1 |
| Aloe, L; Carlini, S; Cavaliere, F; Cavaliere, R; Cavallero, L; Di Filippo, F; Giannarelli, D; Moscarelli, F | 1 |
| Durr, FE; White, RJ | 1 |
| Cumberlin, R; De Moss, E; Friedman, M; Lassus, M | 1 |
| De Vries, EG; Koops, HS; Mulder, NH; Sleijfer, DT; Smit, JM; Willemse, PH | 1 |
| Abdel-Malek, ZA; Amornsiripanitch, N; Nordlund, JJ; Swope, VB | 1 |
| Bijzet, J; Bouman, J; Jurjens, H; Mulder, NH; Sleijfer, DT; Smit, JM; Woldring, MG | 1 |
| Baas, PC; Hoekstra, HJ; Oldhoff, J; Oosterhuis, JW; Schraffordt Koops, H | 1 |
| Kelly, C; Sehgal, RK; Sengupta, SK | 1 |
| Egorov, LV; Perevodchikova, NI; Terent'eva, TG | 1 |
| Baglioni, C; Latham, K; Ruggiero, V | 1 |
| Berlin, RD; Pearson, CM; Preston, SF; Volpi, M | 1 |
| Caltabiano, MM; Greig, RG; Koestler, TP; Poste, G | 1 |
| Carland, K; Kline, EL; Smith, TJ | 1 |
| Ferrone, S; Matsui, M; Temponi, M | 1 |
| Blackmon, B; Carland, KA; Kline, EL; Smith, TJ | 1 |
| Emrich, LJ; Karakousis, CP | 1 |
| Iavorskiĭ, VV; Karaseva, VV; Tokareva, ZI | 1 |
| Banerjee, SS; Craig, P; Gleave, N; Mene, A; Orton, C; Thatcher, N | 1 |
| Kogonia, LM; Moros, LW; Perevodchikova, NJ | 1 |
| Kogoniia, LM; Manziuk, LV; Marenich, AF; Osmanov, DSh; Roshchin, EM | 1 |
| Popp, W; Schwarzacher, HG; Wachtler, F | 1 |
| Ziegler, W | 1 |
| Amato, DA; Ash, A; Borden, EC; Bruckner, H; Creech, RH; Cunningham, TJ; Falkson, G; Guerry, D; Savlov, ED | 1 |
| Creagan, ET; Green, SJ; Long, HJ; Schutt, AJ | 1 |
| Craig, P; Mene, A; Orton, C; Smith, D; Thatcher, N; Wagstaff, J | 1 |
| Baker, LH; Cummings, G; Haas, CD; Samson, MK | 1 |
| Hanauske, AR; Von Hoff, DD | 1 |
| Bassleer, RJ; de Pauw-Gillet, MC; Hennet, JJ | 1 |
| Dunleavy, S; Golomb, F; Harris, M; Hochster, H; Levin, M; Muggia, F; Roses, D; Speyer, J | 1 |
| Cohn, Z; Gordon, S | 1 |
| Frable, WJ; Kay, S; Schatzki, P | 1 |
| Portugalova, VV | 1 |
| Balda, BR; Birkmayer, GD; Miller, F | 1 |
| Benyumovich, MS; Lerman, MI | 1 |
| Falkson, G | 1 |
| Maezaeva, VG | 1 |
| Avdeeva, IA; Mazaeva, VG; Nivinskaia, MM; Romanenko, EA; Sedakova, LA | 1 |
| Zolotkov, AG | 1 |
| Klimenkov, AA; Nivinskaia, MM; Parshikova, SM; Zolotkov, AG | 1 |
| Potapov, SL | 1 |
| Sato, C; Takasawa-Nishizawa, K | 1 |
| Brunat, M; Dargent, M; Pommatau, E | 1 |
| Watt, J | 1 |
| Akopiants, SM; Budkevich, IuV; Gorbunova, VA; Kuchkarev, RN; Titievskaia, VV | 1 |
| Skipper, HE | 1 |
| Freckman, HA | 1 |
| Golomb, FM | 1 |
| Gschwind, C; Hersh, EM; McBride, CM | 1 |
| Didolkar, MS; Gerner, RE; Moore, GE | 1 |
| Hellmann, K | 1 |
| Hall, TC; Miller, S; Nathanson, L; Schilling, A | 1 |
| Körlof, B | 1 |
| Couture, J; Deschênes, L | 1 |
| Bobikov, EV; Radzievskaia, VV; Sazykin, IuO; Terent'eva, TG | 1 |
| McBride, CM | 1 |
| Klein, E | 1 |
| Bottomley, RH; Chanes, RE; Condit, PT; Nisimblat, W | 1 |
| Stehlin, JS | 1 |
9 review(s) available for dactinomycin and Melanoma
| Article | Year |
|---|---|
Isolated limb infusion with melphalan and actinomycin D for melanoma: a systematic review.
Topics: Antibiotics, Antineoplastic; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Cancer, Regional Perfusion; Dactinomycin; Humans; Melanoma; Melphalan; Neoplasm Metastasis | 2014 |
Isolated limb infusion with melphalan and actinomycin D in melanoma patients: factors predictive of acute regional toxicity.
Topics: Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Cancer, Regional Perfusion; Dactinomycin; Extremities; Female; Humans; Hyperthermia, Induced; Infusions, Intra-Arterial; Male; Melanoma; Melphalan; Risk Factors; Skin Neoplasms; Treatment Outcome | 2010 |
Frequency and duration of remission after isolated limb perfusion for melanoma.
Topics: Adult; Aged; Aged, 80 and over; Antibiotics, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Chemotherapy, Cancer, Regional Perfusion; Cisplatin; Dactinomycin; Female; Follow-Up Studies; Humans; Leg; Male; Melanoma; Melphalan; Middle Aged; Neoplasm Recurrence, Local; Remission Induction; Time Factors; Treatment Outcome | 1997 |
Cutaneous malignant melanoma.
Topics: Adult; Aged; Biopsy; Carmustine; Cyclophosphamide; Dactinomycin; Female; Humans; Hydroxyurea; Male; Melanoma; Melphalan; Microscopy, Electron; Middle Aged; Prognosis; Skin Neoplasms; Sunlight; Wounds and Injuries | 1976 |
Isolation perfusion for malignant melanoma of the extremity: a review.
Topics: Arm; Chemotherapy, Cancer, Regional Perfusion; Combined Modality Therapy; Dactinomycin; Humans; Hyperthermia, Induced; Leg; Lymphatic Metastasis; Melanoma; Melphalan; Neoplasm Recurrence, Local; Neoplasm Staging | 1985 |
Isolated regional perfusion in the treatment of subungual melanoma.
Topics: Adult; Aged; Aged, 80 and over; Amputation, Surgical; Chemotherapy, Cancer, Regional Perfusion; Combined Modality Therapy; Dactinomycin; Female; Humans; Lymph Node Excision; Male; Melanoma; Melphalan; Middle Aged; Nail Diseases; Prognosis | 1989 |
[Importance of dactinomycin in the current therapy of tumors].
Topics: Adult; Animals; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Clinical Trials as Topic; Dactinomycin; Dogs; Drug Resistance; Dysgerminoma; Female; Humans; Kidney Neoplasms; Male; Melanoma; Neoplasms; Pregnancy; Sarcoma; Sarcoma, Kaposi; Soft Tissue Neoplasms; Testicular Neoplasms; Trophoblastic Neoplasms; Uterine Neoplasms; Wilms Tumor | 1985 |
Clinical correlations with the human tumor cloning assay.
Topics: Aminoacridines; Amsacrine; Anthracenes; Breast Neoplasms; Clinical Trials as Topic; Clone Cells; Culture Techniques; Dactinomycin; Drug Resistance; Female; Head and Neck Neoplasms; Humans; Interferon Type I; Leukemia; Lung Neoplasms; Melanoma; Multiple Myeloma; Neoplasms; Ovarian Neoplasms; Prospective Studies; Retrospective Studies; Tumor Stem Cell Assay | 1985 |
The use of cytotoxic drugs in the surgery of malignant disease.
Topics: Abdominal Neoplasms; Alkylating Agents; Animals; Antimetabolites; Antineoplastic Agents; Carcinoma, Basal Cell; Choriocarcinoma; Cyclophosphamide; Dactinomycin; Dysgerminoma; Female; Fluorouracil; Head; Head and Neck Neoplasms; Hodgkin Disease; Humans; Injections, Intra-Arterial; Leg; Melanoma; Melphalan; Methotrexate; Neoplasm Metastasis; Neoplasm Recurrence, Local; Neoplasms; Nitrogen Mustard Compounds; Pregnancy; Sarcoma; Sarcoma, Ewing; Skin Neoplasms; Vinblastine; Wilms Tumor | 1968 |
25 trial(s) available for dactinomycin and Melanoma
| Article | Year |
|---|---|
Factors associated with response, survival, and limb salvage in patients undergoing isolated limb infusion.
Topics: Adult; Aged; Amputation, Surgical; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Merkel Cell; Chemotherapy, Cancer, Regional Perfusion; Dactinomycin; Disease Progression; Drug Administration Schedule; Extremities; Female; Humans; Kaplan-Meier Estimate; Limb Salvage; Male; Melanoma; Melphalan; Middle Aged; Neoplasm Staging; Prospective Studies; Retrospective Studies; Sarcoma; Skin Neoplasms; Treatment Outcome; Tumor Burden | 2014 |
Isolated limb infusion for in-transit malignant melanoma of the extremity: a well-tolerated but less effective alternative to hyperthermic isolated limb perfusion.
Topics: Adult; Aged; Aged, 80 and over; Antibiotics, Antineoplastic; Chemotherapy, Cancer, Regional Perfusion; Dactinomycin; Extremities; Female; Humans; Hyperthermia, Induced; Male; Melanoma; Melphalan; Middle Aged; Neoplasm Staging; Prospective Studies; Reproducibility of Results; Skin Neoplasms; Treatment Outcome | 2008 |
Isolated limb infusion with melphalan and dactinomycin for regional melanoma and soft-tissue sarcoma of the extremity: final report of a phase II clinical trial.
Topics: Adult; Aged; Aged, 80 and over; Anesthesia, General; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Brachial Artery; Catheterization, Peripheral; Chemotherapy, Cancer, Regional Perfusion; Dactinomycin; Extremities; Female; Humans; Infusions, Intra-Arterial; Male; Melanoma; Melphalan; Middle Aged; Popliteal Artery; Radiography, Interventional; Remission Induction; Sarcoma | 2009 |
Immunotherapy with dendritic cells pulsed by autologous dactinomycin-induced melanoma apoptotic bodies for patients with malignant melanoma.
Topics: Adult; Aged; Apoptosis; Dactinomycin; Dendritic Cells; Female; Humans; Immunotherapy, Adoptive; Lymph Nodes; Male; Melanoma; Middle Aged; Radiography; Young Adult | 2009 |
Does increased experience with isolated limb infusion for advanced limb melanoma influence outcome? A comparison of two treatment periods at a single institution.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Cancer, Regional Perfusion; Dactinomycin; Extremities; Female; Follow-Up Studies; Humans; Male; Melanoma; Melphalan; Middle Aged; Skin Neoplasms; Survival Rate; Time Factors; Treatment Outcome | 2011 |
Isolated limb infusion with hyperthermia and chemotherapy for advanced limb malignancy: factors influencing toxicity.
Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Cancer, Regional Perfusion; Combined Modality Therapy; Dactinomycin; Dose-Response Relationship, Drug; Extremities; Female; Humans; Hyperthermia, Induced; Male; Melanoma; Melphalan; Middle Aged; Skin Neoplasms; Treatment Outcome | 2014 |
A phase II trial of isolated limb infusion with melphalan and dactinomycin for regional melanoma and soft tissue sarcoma of the extremity.
Topics: Adult; Aged; Aged, 80 and over; Angiography; Chemotherapy, Cancer, Regional Perfusion; Dactinomycin; Extremities; Female; Humans; Male; Melanoma; Melphalan; Middle Aged; Neoplasm Recurrence, Local; Sarcoma; Skin Neoplasms; Treatment Outcome | 2006 |
Combination chemotherapy plus levamisole in the treatment of disseminated malignant melanoma. A Southwest Oncology Group study.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carmustine; Clinical Trials as Topic; Dacarbazine; Dactinomycin; Humans; Hydroxyurea; Levamisole; Melanoma; Random Allocation; Skin Neoplasms | 1984 |
Clinical trial of chlorozotocin, DTIC, and dactinomycin in metastatic malignant melanoma.
Topics: Adolescent; Adult; Bone Marrow; Clinical Trials as Topic; Dacarbazine; Dactinomycin; Digestive System; Drug Therapy, Combination; Female; Humans; Kidney; Male; Melanoma; Middle Aged; Neoplasm Metastasis; Streptozocin | 1982 |
[Comparison of the efficacy of imidazole-carboxamide and of a combination of nitrosomethylurea, vincristine and dactinomycin in disseminated melanoma].
Topics: Adolescent; Adult; Aged; Clinical Trials as Topic; Dacarbazine; Dactinomycin; Drug Therapy, Combination; Female; Humans; Male; Melanoma; Methylnitrosourea; Middle Aged; Neoplasm Metastasis; Nitrosourea Compounds; Skin Neoplasms; Time Factors; Vincristine | 1981 |
Actinomycin-D plus 5-(3,3-dimethyl-1-triazeno)-imidazole-4-carboxamine (DTIC) with or without intravenous Corynebacterium parvum in metastatic malignant melanoma.
Topics: Adolescent; Adult; Aged; Clinical Trials as Topic; Dacarbazine; Dactinomycin; Drug Administration Schedule; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Immunotherapy; Male; Melanoma; Middle Aged; Neoplasm Metastasis; Propionibacterium acnes | 1982 |
Dacarbazine (DTIC)-based chemotherapy or chemoimmunotherapy of patients with disseminated malignant melanoma.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Combined Modality Therapy; Dacarbazine; Dactinomycin; Female; Granulocyte Colony-Stimulating Factor; Humans; Immunotherapy; Interferon-alpha; Male; Melanoma; Middle Aged; Treatment Outcome; Vinblastine | 1994 |
Adjuvant chemotherapy with a nitrosourea-based protocol in advanced malignant melanoma.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Dactinomycin; Female; Humans; Male; Melanoma; Middle Aged; Neoplasm Metastasis; Prospective Studies; Time Factors; Vincristine | 1993 |
Chemoimmunotherapy for disseminated malignant melanoma: a prospective randomized study.
Topics: BCG Vaccine; Clinical Trials as Topic; Dacarbazine; Dactinomycin; Evaluation Studies as Topic; Humans; Immunotherapy; Melanoma; Mycobacterium bovis; Neoplasm Metastasis; Prospective Studies; Triazenes | 1978 |
Phase I--II study of intermittent bolus administration of DTIC and actinomycin D in metastatic malignant melanoma.
Topics: Adult; Aged; Clinical Trials as Topic; Dacarbazine; Dactinomycin; Drug Administration Schedule; Drug Evaluation; Drug Therapy, Combination; Female; Humans; Injections, Intravenous; Male; Melanoma; Middle Aged; Neoplasm Metastasis; Triazenes | 1978 |
[Increase in the effectiveness of the radiation therapy of tumors with actinomycins].
Topics: Animals; Bronchial Neoplasms; Cells, Cultured; Clinical Trials as Topic; Dactinomycin; Drug Evaluation; Humans; In Vitro Techniques; Leukemia, Experimental; Lung Neoplasms; Melanoma; Mesenchymoma; Mice; Neoplasm Metastasis; Neoplasms; Radiotherapy Dosage; Skin Neoplasms | 1979 |
Procarbazine, vinblastine, and actinomycin D in stage III and IV melanoma with or without methanol-extracted residue of Bacillus Calmette-Guérin.
Topics: Antineoplastic Agents; BCG Vaccine; Bone Marrow; Clinical Trials as Topic; Dactinomycin; Digestive System; Drug Therapy, Combination; Female; Humans; Male; Melanoma; Middle Aged; Procarbazine; Remission, Spontaneous; Time Factors; Vinblastine | 1979 |
Comparative evaluation of three combination regimens for advanced malignant melanoma: results of an international cooperative study.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Brain Neoplasms; Carmustine; Central Nervous System Diseases; Dacarbazine; Dactinomycin; Drug Therapy, Combination; Female; Humans; Male; Melanoma; Middle Aged; Neoplasm Metastasis; Remission, Spontaneous; Vincristine | 1976 |
[Importance of dactinomycin in the current therapy of tumors].
Topics: Adult; Animals; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Clinical Trials as Topic; Dactinomycin; Dogs; Drug Resistance; Dysgerminoma; Female; Humans; Kidney Neoplasms; Male; Melanoma; Neoplasms; Pregnancy; Sarcoma; Sarcoma, Kaposi; Soft Tissue Neoplasms; Testicular Neoplasms; Trophoblastic Neoplasms; Uterine Neoplasms; Wilms Tumor | 1985 |
Adjuvant chemotherapy in high-risk malignant melanoma.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carmustine; Clinical Trials as Topic; Combined Modality Therapy; Dactinomycin; Humans; Melanoma; Neoplasm Metastasis; Prospective Studies; Random Allocation; Skin Neoplasms; Vincristine | 1987 |
Randomized study of Corynebacterium parvum adjuvant therapy following surgery for (stage II) malignant melanoma.
Topics: Adjuvants, Immunologic; Adult; Aged; Clinical Trials as Topic; Combined Modality Therapy; Dacarbazine; Dactinomycin; Female; Humans; Male; Melanoma; Middle Aged; Postoperative Period; Propionibacterium acnes; Prospective Studies; Random Allocation; Skin Neoplasms | 1986 |
[Combination chemotherapy of disseminated skin melanoma with nitrosomethylurea].
Topics: Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Dacarbazine; Dactinomycin; Drug Administration Schedule; Humans; Lomustine; Melanoma; Methylnitrosourea; Prognosis; Skin Neoplasms; Vincristine | 1986 |
Corynebacterium parvum followed by chemotherapy (actinomycin D and DTIC) compared with chemotherapy alone for metastatic malignant melanoma.
Topics: Antineoplastic Combined Chemotherapy Protocols; Dacarbazine; Dactinomycin; Humans; Melanoma; Neoplasm Metastasis; Propionibacterium acnes; Prospective Studies; Random Allocation | 1986 |
Clinical correlations with the human tumor cloning assay.
Topics: Aminoacridines; Amsacrine; Anthracenes; Breast Neoplasms; Clinical Trials as Topic; Clone Cells; Culture Techniques; Dactinomycin; Drug Resistance; Female; Head and Neck Neoplasms; Humans; Interferon Type I; Leukemia; Lung Neoplasms; Melanoma; Multiple Myeloma; Neoplasms; Ovarian Neoplasms; Prospective Studies; Retrospective Studies; Tumor Stem Cell Assay | 1985 |
Concurrent combination chemotherapy of human solid tumors: experience with a three-drug regimen and review of the literature.
Topics: Adolescent; Adult; Aged; Bone Marrow; Bone Neoplasms; Carcinoma; Child; Child, Preschool; Clinical Trials as Topic; Cyclophosphamide; Dactinomycin; Drug Synergism; Female; Fluorouracil; Gastrointestinal Neoplasms; Head and Neck Neoplasms; Humans; Lung Neoplasms; Male; Melanoma; Melphalan; Middle Aged; Mitomycins; Parotid Neoplasms; Sarcoma; Urogenital Neoplasms; Vincristine | 1969 |
164 other study(ies) available for dactinomycin and Melanoma
| Article | Year |
|---|---|
Synthesis and some properties and antitumor effects of the actinomycin lactam analog, (di(1-L-alpha, beta-diaminopropionic))actinomycin D1.
Topics: Animals; Antibiotics, Antineoplastic; beta-Lactams; Circular Dichroism; Dactinomycin; Leukemia L1210; Leukemia, Experimental; Male; Melanoma; Mice; Mice, Inbred Strains; Neoplasms, Experimental | 1976 |
Synthesis and biological properties of actinomycin D chromophoric analogues substituted at carbon 7 with aziridine and cyclopropyl functions.
Topics: Aziridines; Dactinomycin; DNA; Humans; Leukemia, Lymphoid; Melanoma; Nucleic Acid Denaturation | 1988 |
Enantiomers of 7-(2,3-epoxypropoxy)actinomycin D as dual-action DNA-acting antitumor agents.
Topics: Animals; Antibiotics, Antineoplastic; Chemical Phenomena; Chemistry; Colonic Neoplasms; Dactinomycin; DNA, Neoplasm; In Vitro Techniques; Leukemia L1210; Melanoma; Mice; Stereoisomerism; Structure-Activity Relationship | 1988 |
Synthesis and biological properties of actinomycin D chromophoric analogues substituted at the 7-carbon with aziridine and aminopropoxy functions.
Topics: Cell Line; Circular Dichroism; Dactinomycin; DNA; Humans; Leukemia, Lymphoid; Melanoma; Structure-Activity Relationship | 1987 |
Synthesis, characterization, and anti-melanoma activity of tetra-O-substituted analogs of nordihydroguaiaretic acid.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Masoprocol; Melanoma; Mice; Xenograft Model Antitumor Assays | 2009 |
International Multicenter Experience of Isolated Limb Infusion for In-Transit Melanoma Metastases in Octogenarian and Nonagenarian Patients.
Topics: Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Australia; Chemotherapy, Cancer, Regional Perfusion; Dactinomycin; Female; Humans; Length of Stay; Lower Extremity; Male; Melanoma; Melphalan; Neoplasm Metastasis; Neoplasm Staging; Neoplasm, Residual; Progression-Free Survival; Skin Neoplasms; Treatment Outcome; Tumor Burden; United States; Upper Extremity | 2020 |
Factors predicting toxicity and response following isolated limb infusion for melanoma: An international multi-centre study.
Topics: Age Factors; Aged; Aged, 80 and over; Amputation, Surgical; Antineoplastic Combined Chemotherapy Protocols; Australia; Chemotherapy, Cancer, Regional Perfusion; Creatine Kinase; Dactinomycin; Dose-Response Relationship, Drug; Female; Humans; Ischemia; Lower Extremity; Male; Melanoma; Melphalan; Middle Aged; Neoplasm Metastasis; Sex Factors; Skin Neoplasms; Time Factors; Tourniquets; United States; Upper Extremity | 2020 |
Outcomes and Predictive Factors of Isolated Limb Infusion for Patients with In-transit Melanoma in China.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Cancer, Regional Perfusion; China; Dactinomycin; Extremities; Female; Follow-Up Studies; Humans; Male; Melanoma; Melphalan; Middle Aged; Prospective Studies; Survival Rate; Treatment Outcome; Young Adult | 2018 |
Evaluation of the efficacy and toxicity of upper extremity isolated limb infusion chemotherapy for melanoma: An Australian multi-center study.
Topics: Aged; Aged, 80 and over; Antibiotics, Antineoplastic; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Australia; Chemotherapy, Cancer, Regional Perfusion; Dactinomycin; Female; Humans; Lymph Node Excision; Lymphatic Metastasis; Male; Melanoma; Melphalan; Middle Aged; Prospective Studies; Skin Neoplasms; Upper Extremity | 2019 |
Resection of residual disease after isolated limb infusion (ILI) is equivalent to a complete response after ILI-alone in advanced extremity melanoma.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Cancer, Regional Perfusion; Combined Modality Therapy; Dactinomycin; Extremities; Female; Follow-Up Studies; Humans; Male; Melanoma; Melphalan; Middle Aged; Neoplasm Staging; Neoplasm, Residual; Prognosis; Remission Induction; Retrospective Studies; Survival Rate | 2014 |
Congenital uveal malignant melanoma.
Topics: Antineoplastic Agents; Combined Modality Therapy; Dactinomycin; Eye Enucleation; Female; Humans; Infant; Magnetic Resonance Imaging; Melanoma; Neoplasm Invasiveness; Uveal Neoplasms; Vincristine | 2014 |
Burden of disease predicts response to isolated limb infusion with melphalan and actinomycin D in melanoma.
Topics: Adult; Aged; Aged, 80 and over; Antibiotics, Antineoplastic; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Cancer, Regional Perfusion; Dactinomycin; Female; Humans; Leg; Male; Melanoma; Melphalan; Middle Aged; Multivariate Analysis; Neoplasm Seeding; Retrospective Studies; Skin Neoplasms | 2015 |
Actinomycin D and nutlin-3a synergistically promote phosphorylation of p53 on serine 46 in cancer cell lines of different origin.
Topics: Cell Line, Tumor; Dactinomycin; Gene Expression Regulation, Neoplastic; Humans; Imidazoles; Melanoma; Phosphorylation; Piperazines; Proto-Oncogene Proteins c-mdm2; Serine; Tumor Suppressor Protein p53 | 2015 |
Computed Tomography-Based Limb Volume Measurements for Isolated Limb Infusion in Melanoma.
Topics: Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Cancer, Regional Perfusion; Dactinomycin; Disease Progression; Feasibility Studies; Follow-Up Studies; Humans; Image Processing, Computer-Assisted; Lower Extremity; Melanoma; Melphalan; Neoplasm Staging; Prognosis; Retrospective Studies; Skin Neoplasms; Tomography, X-Ray Computed | 2016 |
Australian Multicenter Study of Isolated Limb Infusion for Melanoma.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Australia; Chemotherapy, Cancer, Regional Perfusion; Dactinomycin; Female; Follow-Up Studies; Humans; Lower Extremity; Male; Melanoma; Melphalan; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Staging; Prognosis; Prospective Studies; Skin Neoplasms; Survival Rate | 2016 |
Clinical Response and Regional Toxicity Following Isolated Limb Infusion Compared with Isolated Limb Perfusion for In-Transit Melanoma.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Cancer, Regional Perfusion; Dactinomycin; Extremities; Female; Follow-Up Studies; Humans; Lymphatic Metastasis; Male; Melanoma; Melphalan; Prognosis; Retrospective Studies; Skin Neoplasms; Survival Rate | 2016 |
Outcomes following isolated limb infusion for melanoma. A 14-year experience.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Cancer, Regional Perfusion; Dactinomycin; Extremities; Female; Humans; Male; Melanoma; Melphalan; Middle Aged; Neoplasm Recurrence, Local; Prognosis; Prospective Studies; Skin Neoplasms; Survival Rate; Time Factors; Treatment Outcome | 2008 |
Identification of ARHGEF17, DENND2D, FGFR3, and RB1 mutations in melanoma by inhibition of nonsense-mediated mRNA decay.
Topics: Codon, Nonsense; Dactinomycin; DNA-Binding Proteins; Emetine; Guanine Nucleotide Exchange Factors; Humans; Melanoma; Mutation; Receptor, Fibroblast Growth Factor, Type 3; Retinoblastoma Protein; Rho Guanine Nucleotide Exchange Factors; RNA Stability; RNA, Messenger; Tumor Cells, Cultured | 2008 |
p16INK4a expression and absence of activated B-RAF are independent predictors of chemosensitivity in melanoma tumors.
Topics: Aged; Aged, 80 and over; Antineoplastic Agents; Apoptosis; Cell Cycle; Cyclin-Dependent Kinase Inhibitor p16; Dactinomycin; Female; Gene Expression Regulation, Neoplastic; Genes, p16; Genes, ras; Humans; Male; Melanoma; Melphalan; Microphthalmia-Associated Transcription Factor; Middle Aged; Mutation; Polymorphism, Single-Stranded Conformational; Proto-Oncogene Proteins B-raf; PTEN Phosphohydrolase; Reverse Transcriptase Polymerase Chain Reaction; Statistics, Nonparametric; Tumor Suppressor Protein p14ARF | 2008 |
Isolated limb infusion as palliative treatment for advanced limb disease in patients with AJCC stage IV melanoma.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Cancer, Regional Perfusion; Dactinomycin; Extremities; Female; Humans; Hyperthermia, Induced; Male; Melanoma; Melphalan; Middle Aged; Neoplasm Staging; Palliative Care; Skin Neoplasms | 2009 |
Factors predictive of acute regional toxicity after isolated limb infusion with melphalan and actinomycin D in melanoma patients.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Cancer, Regional Perfusion; Dactinomycin; Extremities; Female; Humans; Hyperthermia, Induced; Male; Melanoma; Melphalan; Middle Aged; Skin Neoplasms | 2009 |
Efficacy of repeat isolated limb infusion with melphalan and actinomycin D for recurrent melanoma.
Topics: Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Cancer, Regional Perfusion; Dactinomycin; Disease Progression; Female; Humans; Leg; Male; Melanoma; Melphalan; Middle Aged; Recurrence; Skin Neoplasms; Survival Analysis; Time Factors; Treatment Outcome | 2009 |
A multi-institutional experience of isolated limb infusion: defining response and toxicity in the US.
Topics: Adult; Aged; Aged, 80 and over; Antibiotics, Antineoplastic; Antineoplastic Agents, Alkylating; Chemotherapy, Cancer, Regional Perfusion; Dactinomycin; Drug Therapy, Combination; Extremities; Female; Humans; Hyperthermia, Induced; Male; Melanoma; Melphalan; Middle Aged; Multivariate Analysis; Papaverine; Retrospective Studies; Skin Neoplasms; Treatment Outcome; United States; Young Adult | 2009 |
Long-term outcome of hyperthermic isolated limb perfusion (HILP) in the treatment of locoregionally metastasised malignant melanoma of the extremities.
Topics: Adult; Aged; Aged, 80 and over; Chemotherapy, Cancer, Regional Perfusion; Dactinomycin; Extremities; Female; Humans; Hyperthermia, Induced; Kaplan-Meier Estimate; Male; Melanoma; Melphalan; Middle Aged; Neoplasm Metastasis; Skin Neoplasms; Treatment Outcome | 2010 |
Use of an automated circuit for isolated limb infusion for malignancy.
Topics: Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Cancer, Regional Perfusion; Dactinomycin; Female; Heart Arrest, Induced; Humans; Lower Extremity; Male; Melanoma; Melphalan; Middle Aged; Skin Neoplasms; Treatment Outcome | 2010 |
SPARC functions as an anti-stress factor by inactivating p53 through Akt-mediated MDM2 phosphorylation to promote melanoma cell survival.
Topics: Animals; Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; Cell Line, Tumor; Cell Survival; Dactinomycin; Gene Knockdown Techniques; Humans; Melanoma; Mice; Osteonectin; Oxidative Stress; Phosphorylation; Protein Binding; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-mdm2; Reactive Oxygen Species; RNA Interference; Signal Transduction; Time Factors; Tumor Suppressor Protein p53; Up-Regulation | 2011 |
Technique and outcomes of isolated limb infusion for locally advanced malignant melanoma--a radiological perspective.
Topics: Aged; Angiography; Chemotherapy, Cancer, Regional Perfusion; Dactinomycin; Extremities; Female; Humans; Infusion Pumps; Melanoma; Melphalan; Neoplasm Staging; Postoperative Care; Preoperative Care; Prognosis; Retrospective Studies; Skin Neoplasms; Survival Analysis; Tomography, X-Ray Computed; Treatment Outcome | 2011 |
A multi-institutional experience of repeat regional chemotherapy for recurrent melanoma of extremities.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Cancer, Regional Perfusion; Dactinomycin; Drug Administration Schedule; Female; Humans; Length of Stay; Male; Melanoma; Melphalan; Middle Aged; Neoplasm Grading; Neoplasm Recurrence, Local; Retrospective Studies; Skin Neoplasms; Treatment Outcome | 2012 |
Quality of life outcomes after isolated limb infusion.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Arm; Carcinoma, Merkel Cell; Cross-Sectional Studies; Dactinomycin; Edema; Female; Follow-Up Studies; Humans; Hypesthesia; Infusions, Intravenous; Leg; Length of Stay; Male; Melanoma; Melphalan; Neoplasm Recurrence, Local; Quality of Life; Skin Neoplasms; Survival Rate | 2012 |
Patterns of recurrence following complete response to regional chemotherapy for in-transit melanoma.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Cancer, Regional Perfusion; Combined Modality Therapy; Dactinomycin; Female; Follow-Up Studies; Humans; Hyperthermia, Induced; Male; Melanoma; Melphalan; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Staging; Prognosis; Prospective Studies; Remission Induction; Survival Rate | 2012 |
Evodiamine, a constituent of Evodiae Fructus, induces anti-proliferating effects in tumor cells.
Topics: Alkaloids; Amino Acid Chloromethyl Ketones; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Caspases; Cell Division; Cysteine Proteinase Inhibitors; Dactinomycin; DNA Fragmentation; Drug Screening Assays, Antitumor; Enzyme Activation; Evodia; Fibrosarcoma; Fluorouracil; Furans; Gene Expression Regulation, Neoplastic; Genes, bcl-2; HeLa Cells; Hepatocytes; Heterocyclic Compounds, 4 or More Rings; Humans; Indole Alkaloids; Leukemia, Monocytic, Acute; Leukocytes, Mononuclear; Melanoma; Mice; Mitochondria; Molecular Structure; Neoplasm Proteins; Oligopeptides; Plant Extracts; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Quinazolines; Rats; Rats, Inbred BUF; Sarcoma 180; Tumor Cells, Cultured | 2003 |
Transcriptional profiling of targets for combination therapy of lung carcinoma with paclitaxel and mitogen-activated protein/extracellular signal-regulated kinase kinase inhibitor.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Butadienes; Chemokine CXCL1; Chemokines; Chemokines, CXC; Chemotactic Factors; Dactinomycin; Enzyme Inhibitors; Female; Gene Expression Profiling; Humans; Intercellular Signaling Peptides and Proteins; Lung Neoplasms; Melanoma; Mitogen-Activated Protein Kinase Kinases; Nitriles; Oligonucleotide Array Sequence Analysis; Ovarian Neoplasms; Paclitaxel | 2003 |
THE TREATMENT OF MALIGNANT DISEASE BY REGIONAL CHEMOTHERAPY.
Topics: Antimetabolites; Antineoplastic Agents; Carcinoma, Squamous Cell; Chemotherapy, Cancer, Regional Perfusion; Dactinomycin; Geriatrics; Head and Neck Neoplasms; Humans; Infusions, Parenteral; Melanoma; Melphalan; Methotrexate; Mouth Neoplasms; Neoplasms; Neoplasms, Muscle Tissue; Nitrogen Mustard Compounds; Sarcoma; Toxicology; Triethylenemelamine | 1963 |
[CURRENT PRACTICE IN THE TREATMENT OF TUMORS WITH INTRA-ARTERIAL INJECTIONS OF ANTINEOPLASTIC SUBSTANCES].
Topics: Aminopterin; Antineoplastic Agents; Carcinoma; Chemotherapy, Cancer, Regional Perfusion; Chlorambucil; Dactinomycin; Fibrosarcoma; Fluoresceins; Humans; Infusions, Parenteral; Injections, Intra-Arterial; Lymphoma; Lymphoma, Non-Hodgkin; Melanoma; Melphalan; Neoplasms; Pharmacology; Thiotepa; Toxicology | 1963 |
STUDIES ON HUMAN MELANOMA CELLS IN TISSUE CULTURE. II. EFFECTS OF SEVERAL CANCER CHEMOTHERAPEUTIC AGENTS ON CYTOLOGY AND GROWTH.
Topics: Anti-Bacterial Agents; Antineoplastic Agents; Chlorambucil; Dactinomycin; Fluorouracil; Melanoma; Methotrexate; Neoplasms; Nitrogen Mustard Compounds; Pharmacology; Thiotepa; Tissue Culture Techniques | 1964 |
AURANTIN--A COMPLEX ANTIBIOTIC SUBSTANCE OF THE ACTINOMYCIN GROUP: ITS PROPERTIES AND RESULTS OF CLINICAL TRIALS ON VARIOUS TYPES OF NEOPLASMS.
Topics: Adenocarcinoma; Adrenal Cortex Hormones; Animals; Anti-Bacterial Agents; Antineoplastic Agents; Brain Neoplasms; Breast Neoplasms; Carcinoma, Ehrlich Tumor; Dactinomycin; Dysgerminoma; Female; Hodgkin Disease; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Melanoma; Mice; Neoplasms; Neoplasms, Experimental; Ovarian Neoplasms; Pharmacology; Rabbits; Rectal Neoplasms; Research; Sarcoma; Sarcoma, Experimental; Tissue Culture Techniques | 1964 |
INDIVIDUALIZED CHEMOTHERAPY BY IN VITRO DRUG SELECTION.
Topics: Antineoplastic Agents; Bone Neoplasms; Dactinomycin; Female; Floxuridine; Fluorouracil; Genital Neoplasms, Female; Humans; In Vitro Techniques; Intestinal Neoplasms; Leukemia; Mechlorethamine; Melanoma; Mercaptopurine; Methotrexate; Neoplasms; Pharyngeal Neoplasms; Respiratory Tract Neoplasms; Stomach Neoplasms; Thiotepa | 1964 |
ISOLATION PERFUSION: EVALUATION OF 249 CASES.
Topics: Chemotherapy, Cancer, Regional Perfusion; Coccidioidomycosis; Dactinomycin; Drug Hypersensitivity; Drug Therapy; Hematologic Diseases; Humans; Melanoma; Melphalan; Mycetoma; Neoplasms; Sarcoma; Sepsis; Toxicology | 1964 |
[COMPARATIVE DATA ON THE EFFECT OF ACTINOMYCIN C AND K ON HUMAN TUMOR CELLS IN TISSUE CULTURE].
Topics: Dactinomycin; Hemangiosarcoma; Kidney Neoplasms; Melanoma; Mesonephroma; Neoplasms; Neoplasms, Experimental; Pancreatic Neoplasms; Pharmacology; Research; Stomach Neoplasms; Tissue Culture Techniques | 1964 |
Induction of apoptosis and/or necrosis following exposure to antitumour agents in a melanoma cell line, probably through modulation of Bcl-2 family proteins.
Topics: Annexin A5; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Apoptosis; Blotting, Western; Caspase 3; Caspases; Cell Death; Cell Line, Tumor; Cell Survival; Cisplatin; Coloring Agents; Dacarbazine; Dactinomycin; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Activation; Flow Cytometry; Fluorescent Dyes; Humans; Melanoma; Necrosis; Proto-Oncogene Proteins c-bcl-2; Time Factors; Trypan Blue; Up-Regulation | 2003 |
Pretreatment with PKC inhibitor triggers TNF-alpha induced apoptosis in TNF-alpha-resistant B16 melanoma BL6 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Antineoplastic Agents; Apoptosis; Butadienes; Caspase 3; Caspases; Cell Division; Cell Line, Tumor; Cell Survival; Dactinomycin; Dose-Response Relationship, Drug; Drug Combinations; Drug Resistance, Neoplasm; Enzyme Inhibitors; Melanoma; Mice; Nitriles; Phosphorylation; Protein Kinase C; Tumor Necrosis Factor-alpha | 2003 |
Translational control of tumor necrosis factor-related apoptosis-inducing ligand death receptor expression in melanoma cells.
Topics: 3' Untranslated Regions; 5' Untranslated Regions; Apoptosis; Base Sequence; Cell Line, Tumor; Cytoplasm; Cytosol; Dactinomycin; DNA, Complementary; Flow Cytometry; Gene Expression Regulation; Genes, Reporter; Humans; Kinetics; Luciferases; Melanoma; Molecular Sequence Data; Plasmids; Protein Binding; Protein Biosynthesis; Receptors, TNF-Related Apoptosis-Inducing Ligand; Receptors, Tumor Necrosis Factor; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA; RNA Processing, Post-Transcriptional; RNA, Messenger; Time Factors; Transcription, Genetic; Transfection | 2004 |
Quercetin enhances melanogenesis by increasing the activity and synthesis of tyrosinase in human melanoma cells and in normal human melanocytes.
Topics: Animals; Cells, Cultured; Cycloheximide; Dactinomycin; Flavonoids; Gene Expression Regulation, Enzymologic; Humans; Melanins; Melanocytes; Melanoma; Monophenol Monooxygenase; Quercetin | 2004 |
Hyperthermic isolated limb perfusion (HILP) in malignant melanoma. Experience with 101 patients.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Cancer, Regional Perfusion; Dactinomycin; Extremities; Female; Humans; Hyperthermia, Induced; Male; Melanoma; Melphalan; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Staging; Postoperative Complications; Surgical Procedures, Operative; Survival Analysis; Treatment Outcome | 2006 |
Congenital uveal malignant melanoma: a case report.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Dactinomycin; Eye Enucleation; Follow-Up Studies; Gestational Age; Humans; Infant, Newborn; Male; Melanoma; Neoplasm Invasiveness; Remission Induction; Skin Neoplasms; Uveal Neoplasms; Vincristine | 2005 |
Human placental protein/peptides stimulate melanin synthesis by enhancing tyrosinase gene expression.
Topics: Animals; Cell Culture Techniques; Chromatography, High Pressure Liquid; Dactinomycin; Gene Expression; Gene Expression Profiling; Humans; Melanins; Melanocytes; Melanoma; Mice; Monophenol Monooxygenase; Pregnancy Proteins; Promoter Regions, Genetic; Tumor Cells, Cultured; Up-Regulation | 2006 |
Downregulation of survivin expression enhances sensitivity of cultured uveal melanoma cells to cisplatin treatment.
Topics: Antibiotics, Antineoplastic; Antineoplastic Agents; Apoptosis; Caspase 3; Caspases; Cell Division; Cell Line, Tumor; Cisplatin; Dactinomycin; DNA, Circular; DNA, Neoplasm; Down-Regulation; Flow Cytometry; Humans; Inhibitor of Apoptosis Proteins; Melanoma; Microtubule-Associated Proteins; Neoplasm Proteins; Survivin; Transfection; Up-Regulation; Uveal Neoplasms | 2006 |
CD13/Aminopeptidase N overexpression by basic fibroblast growth factor mediates enhanced invasiveness of 1F6 human melanoma cells.
Topics: CD13 Antigens; Cell Line, Tumor; Cell Movement; Collagen; Dactinomycin; Drug Combinations; Fibroblast Growth Factor 2; Gene Expression Regulation, Enzymologic; Genes, Reporter; Humans; Laminin; Melanoma; Neoplasm Invasiveness; Neoplasm Metastasis; Promoter Regions, Genetic; Proteoglycans; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Skin Neoplasms; Transfection | 2006 |
Transcriptional activation of tyrosinase gene by human placental sphingolipid.
Topics: Animals; Cycloheximide; Dactinomycin; Dose-Response Relationship, Drug; Female; Gene Expression Regulation, Enzymologic; Humans; Melanocytes; Melanoma; Mice; Monophenol Monooxygenase; Placenta; Pregnancy; Promoter Regions, Genetic; RNA, Messenger; Sphingolipids; Transcriptional Activation; Tumor Cells, Cultured | 2006 |
FDG PET/CT demonstrates the effectiveness of isolated limb infusion for malignant melanoma.
Topics: Antineoplastic Combined Chemotherapy Protocols; Dactinomycin; Fluorodeoxyglucose F18; Infusions, Intra-Arterial; Lymphatic Metastasis; Melanoma; Melphalan; Positron-Emission Tomography; Radiopharmaceuticals; Skin Neoplasms; Tomography, X-Ray Computed; Treatment Outcome | 2006 |
Long-term results of hyperthermic, isolated limb perfusion for melanoma: a reflection of tumor biology.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Chemotherapy, Cancer, Regional Perfusion; Dactinomycin; Extremities; Female; Humans; Hyperthermia, Induced; Male; Melanoma; Melphalan; Middle Aged; Remission Induction; Retrospective Studies; Skin Neoplasms; Treatment Outcome | 2007 |
Disseminated melanoma. Biologic behavior and treatment.
Topics: Antineoplastic Agents; Chlorambucil; Cyclophosphamide; Dactinomycin; Fluorouracil; Humans; Hydrazines; Hydroxyurea; Lymph Node Excision; Lymphatic Metastasis; Melanoma; Melphalan; Methotrexate; Neoplasm Metastasis; Neoplasm Recurrence, Local; Perfusion; Vincristine | 1967 |
Induced remission of malignant melanoma with actinomycin D. Immunologic implications.
Topics: Adult; Chemotherapy, Cancer, Regional Perfusion; Dactinomycin; Female; Follow-Up Studies; Humans; Hypersensitivity, Delayed; Injections, Intravenous; Male; Melanoma; Middle Aged | 1967 |
Retinoids increase transglutaminase activity and inhibit ornithine decarboxylase activity in Chinese hamster ovary cells and in melanoma cells stimulated to differentiate.
Topics: Animals; Carboxy-Lyases; Cell Differentiation; Cell Line; Cricetinae; Cricetulus; Cycloheximide; Dactinomycin; Female; gamma-Glutamyltransferase; Kinetics; Melanocyte-Stimulating Hormones; Melanoma; Mice; Neoplasms, Experimental; Ornithine Decarboxylase Inhibitors; Ovary; Tretinoin; Vitamin A | 1982 |
Regulation of cell division and of tyrosinase in B16 melanoma cells by imidazole: a possible role for the concept of metabolite gene regulation in mammalian cells.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Catechol Oxidase; Cell Division; Cyclic AMP; Cycloheximide; Dactinomycin; Enzyme Induction; Gene Expression Regulation; Imidazoles; Melanoma; Mice; Monophenol Monooxygenase; Neoplasms, Experimental; Theophylline | 1981 |
Modern problems of clinical chemotherapy of malignant tumours.
Topics: Antineoplastic Agents; Carcinoma, Small Cell; Carubicin; Dacarbazine; Dactinomycin; Drug Therapy, Combination; Female; Humans; Lomustine; Lung Neoplasms; Male; Melanoma; Methylnitrosourea; Neoplasms; Sarcoma; Skin Neoplasms; Soft Tissue Neoplasms; Vincristine | 1980 |
Potential biological explanation of stimulation of colony growth in semi-solid agar by cytotoxic agents.
Topics: Agar; Animals; Cell Count; Cell Division; Cell Line; Clone Cells; Cytological Techniques; Dactinomycin; Female; Humans; Melanoma; Melphalan; Mice; Stimulation, Chemical | 1983 |
A morphological characterization of melanoma tumor cell interaction with a basement membrane model in the absence and presence of an anticancer agent.
Topics: Antineoplastic Agents; Basement Membrane; Cell Line; Dactinomycin; Fluorescent Antibody Technique; Humans; Melanoma; Microscopy, Electron, Scanning; Neoplasm Invasiveness | 1984 |
Effect of the inhibition of nucleic acids and protein synthesis upon the development of melanotic tumors in Drosophila.
Topics: Animals; Cell Division; Chloramphenicol; Cycloheximide; Dactinomycin; Drosophila melanogaster; Ethidium; Melanoma; Mitomycin; Mitomycins; Nucleic Acids; Protein Biosynthesis | 1983 |
Effects of actinomycin D and cycloheximide on the increase in tyrosinase activity of hamster amelanotic melanoma cells in vitro.
Topics: Animals; Catechol Oxidase; Cricetinae; Culture Media; Cycloheximide; Dactinomycin; In Vitro Techniques; Melanoma; Monophenol Monooxygenase; Protein Biosynthesis; Transcription, Genetic | 1984 |
Scanning and transmission electron microscopic evaluation of human melanoma cells treated with adriamycin and actinomycin D.
Topics: Cell Line; Dactinomycin; Doxorubicin; Humans; Lymph Nodes; Lymphatic Metastasis; Melanoma; Microscopy, Electron; Microscopy, Electron, Scanning; Skin Neoplasms | 1983 |
Human tumor colony assay and chemosensitivity testing.
Topics: Antineoplastic Agents; Cell Line; Cell Survival; Clone Cells; Colonic Neoplasms; Dactinomycin; Drug Evaluation; Drug Evaluation, Preclinical; Humans; Melanoma | 1984 |
[Complex therapy of melanoma metastases in the lung].
Topics: Adult; Combined Modality Therapy; Dactinomycin; Female; Humans; Lung Neoplasms; Male; Melanoma; Middle Aged | 1984 |
15 years' experience with hyperthermic perfusion for treatment of soft tissue sarcoma and malignant melanoma of the extremities.
Topics: Amputation, Surgical; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Dactinomycin; Extremities; Humans; Hyperthermia, Induced; Injections, Intravenous; Melanoma; Melphalan; Perfusion; Sarcoma; Soft Tissue Neoplasms | 1984 |
[The possible modes of action of TNF (tumor necrosis factor)].
Topics: Animals; Cell Division; Cell Movement; Cell Survival; Dactinomycin; Glycoproteins; Growth Inhibitors; Humans; Liver Neoplasms, Experimental; Lymphokines; Melanoma; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Rabbits; Tumor Necrosis Factor-alpha | 1984 |
In vitro production of rabbit macrophage tumor cell cytotoxin.
Topics: Animals; Bone Marrow; Cell Line; Cytotoxins; Dactinomycin; Female; Fibroblasts; Glycoproteins; Growth Inhibitors; Kinetics; Lung; Macrophages; Melanoma; Molecular Weight; Monocytes; Neoplasms, Experimental; Rabbits; Time Factors; Tumor Necrosis Factor-alpha | 1983 |
[New modifications in isolated extremity perfusion ].
Topics: Antineoplastic Agents; Arm; Chemotherapy, Cancer, Regional Perfusion; Cisplatin; Dacarbazine; Dactinomycin; Drug Therapy, Combination; Hot Temperature; Humans; Leg; Mechlorethamine; Melanoma; Melphalan; Skin Neoplasms | 1982 |
Tourniquet infusion versus hyperthermic perfusion.
Topics: Aged; Animals; Antineoplastic Agents; Carcinoma, Squamous Cell; Chemotherapy, Cancer, Regional Perfusion; Dactinomycin; Dogs; Doxorubicin; Extremities; Female; Hindlimb; Humans; Infusions, Intra-Arterial; Male; Melanoma; Melphalan; Middle Aged; Sarcoma; Skin Neoplasms; Tissue Distribution; Tourniquets | 1982 |
Hyperthermic regional perfusion with melphalan and a combination of melphalan and actinomycin D in the treatment of locally metastasized malignant melanomas of the extremities.
Topics: Adult; Aged; Chemotherapy, Cancer, Regional Perfusion; Dactinomycin; Drug Therapy, Combination; Extremities; Female; Hot Temperature; Humans; Male; Melanoma; Melphalan; Middle Aged; Neoplasm Metastasis; Neoplasm Recurrence, Local | 1982 |
Prevention of intravascular metastases of B16 murine melanoma: adjuvant chemotherapy with actinomycin D.
Topics: Animals; Cell Line; Dactinomycin; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Evaluation, Preclinical; Lung Neoplasms; Melanoma; Mice; Mice, Inbred C57BL; Neoplasm Transplantation; Neoplasms, Experimental; Neoplastic Cells, Circulating | 1982 |
Quantitation of drug sensitivity by human metastatic melanoma colony-forming units.
Topics: Antineoplastic Agents; Cell Survival; Cells, Cultured; Clone Cells; Dactinomycin; Drug Resistance; Humans; Melanoma | 1981 |
Regional perfusion in the treatment of patients with a locally metastasized malignant melanoma of the limbs.
Topics: Chemotherapy, Cancer, Regional Perfusion; Dactinomycin; Extremities; Female; Follow-Up Studies; Hot Temperature; Humans; Male; Melanoma; Melphalan; Neoplasm Recurrence, Local; Neoplasm Staging; Sex Factors | 1981 |
Hyperthermic isolated limb perfusion increases circulating levels of inflammatory cytokines.
Topics: Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Cancer, Regional Perfusion; Combined Modality Therapy; Cytokines; Dactinomycin; Drug Administration Schedule; Extremities; Humans; Hyperthermia, Induced; Inflammation; Infusion Pumps; Mechlorethamine; Melanoma | 1995 |
Functional evidence that transmembrane 12 and the loop between transmembrane 11 and 12 form part of the drug-binding domain in P-glycoprotein encoded by MDR1.
Topics: Affinity Labels; Amino Acid Sequence; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Binding Sites; Cell Line; Cisplatin; Colchicine; Dactinomycin; Doxorubicin; Drug Resistance, Multiple; Humans; Iodine Radioisotopes; Melanoma; Molecular Sequence Data; Phenotype; Prazosin; Protein Structure, Secondary; Recombinant Fusion Proteins; Sequence Homology, Amino Acid; Transfection; Tumor Cells, Cultured; Vincristine | 1995 |
Hyperthermic isolation limb perfusion (HILP) in the management of extremity melanoma and sarcoma with particular reference to the dosage, pharmacokinetics, and toxicity of cisplatin.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant; Chemotherapy, Cancer, Regional Perfusion; Cisplatin; Combined Modality Therapy; Dacarbazine; Dactinomycin; Evaluation Studies as Topic; Extremities; Humans; Hyperthermia, Induced; Incidence; Melanoma; Melphalan; Neoplasm Metastasis; Osteosarcoma; Rhabdomyolysis; Skin Neoplasms; Treatment Outcome | 1993 |
(R,R)-2,2'-[1,2-ethanediylbis[imino(1-methyl-2,1-ethanediyl)]]- bis[5-nitro-1H-benz[de]isoquinoline-1,3-(2H)-dione] dimethanesulfonate (DMP 840), a novel bis-naphthalimide with potent nonselective tumoricidal activity in vitro.
Topics: Amsacrine; Animals; Antineoplastic Agents; Cell Division; Clinical Trials, Phase I as Topic; Colonic Neoplasms; Dactinomycin; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance; Drug Screening Assays, Antitumor; Humans; Isoquinolines; KB Cells; Kinetics; Leucine; Leukemia L1210; Leukemia P388; Mammary Neoplasms, Experimental; Melanoma; Melanoma, Experimental; Mesylates; Mice; Mitoxantrone; Thymidine; Transplantation, Heterologous; Tumor Cells, Cultured; Uridine | 1994 |
Polyamine and polyamine analog regulation of spermidine/spermine N1-acetyltransferase in MALME-3M human melanoma cells.
Topics: Acetyltransferases; Adenosylmethionine Decarboxylase; Base Sequence; Blotting, Northern; Dactinomycin; Half-Life; Humans; Melanoma; Molecular Sequence Data; Ornithine Decarboxylase Inhibitors; Polyamines; RNA, Messenger; Spermine; Transcription, Genetic; Tumor Cells, Cultured | 1993 |
[Successful treatment of melanoblastoma in a child].
Topics: Antibiotics, Antineoplastic; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Child; Cisplatin; Combined Modality Therapy; Dactinomycin; Female; Humans; Lymph Node Excision; Lymphatic Metastasis; Melanoma; Radioisotope Teletherapy; Skin Neoplasms; Vinblastine; Vincristine | 1995 |
[Certain aspects of prevention and treatment of cutaneous melanoblastoma].
Topics: Adult; Antibiotics, Antineoplastic; Antineoplastic Agents, Phytogenic; Combined Modality Therapy; Dactinomycin; Female; Follow-Up Studies; Humans; Lymphatic Metastasis; Male; Melanoma; Middle Aged; Skin Neoplasms; Time Factors; Vincristine | 1996 |
Reactive oxygen intermediates increase vascular endothelial growth factor expression in vitro and in vivo.
Topics: Animals; Antioxidants; Cattle; Cells, Cultured; Cycloheximide; Dactinomycin; Endothelial Growth Factors; Enzyme Inhibitors; Gene Expression Regulation, Developmental; Glioblastoma; Half-Life; Humans; Hydrogen Peroxide; Lymphokines; Melanoma; Neovascularization, Pathologic; Neovascularization, Physiologic; Oxygen; Pigment Epithelium of Eye; Rabbits; Rats; Reactive Oxygen Species; Reperfusion; Retina; RNA, Messenger; Superoxides; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 1996 |
Interferon-beta prevents the upregulation of interleukin-8 expression in human melanoma cells.
Topics: Animals; Cycloheximide; Dactinomycin; Female; Gene Expression Regulation, Neoplastic; Humans; Interferon alpha-2; Interferon-alpha; Interferon-beta; Interferon-gamma; Interleukin-1; Interleukin-10; Interleukin-8; Lung Neoplasms; Lymphatic Metastasis; Melanoma; Mice; Mice, Nude; Middle Aged; Neoplasm Proteins; Nucleic Acid Synthesis Inhibitors; Protein Synthesis Inhibitors; Recombinant Proteins; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1996 |
Role of microphthalmia transcription factor in regulation of melanocyte differentiation marker TRP-1.
Topics: Acetamides; Blotting, Western; Cell Nucleus; Cell Size; Cholera Toxin; Cycloheximide; Dactinomycin; DNA-Binding Proteins; Down-Regulation; Gene Expression Regulation; Half-Life; Humans; Melanins; Melanocytes; Melanoma; Membrane Glycoproteins; Microphthalmia-Associated Transcription Factor; Monophenol Monooxygenase; Oxidoreductases; Protein Biosynthesis; Proteins; RNA, Messenger; Tetradecanoylphorbol Acetate; Transcription Factors; Tumor Cells, Cultured | 1999 |
Safe, compact and portable system for regional chemotherapeutic hyperthermic perfusion procedures.
Topics: Adult; Aged; Arm; Chemotherapy, Cancer, Regional Perfusion; Combined Modality Therapy; Dactinomycin; Drug Combinations; Female; Humans; Hyperthermia, Induced; Leg; Male; Mechlorethamine; Melanoma; Middle Aged; Thiotepa; Treatment Outcome | 1993 |
Down-regulation of tumor necrosis factor alpha expression by activating transcription factor 2 increases UVC-induced apoptosis of late-stage melanoma cells.
Topics: Activating Transcription Factor 2; Apoptosis; Cyclic AMP Response Element-Binding Protein; Cycloheximide; Dactinomycin; Down-Regulation; Gene Expression Regulation; Humans; Leucine Zippers; Melanoma; Protein Synthesis Inhibitors; Radiation Tolerance; Transcription Factors; Transfection; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Ultraviolet Rays | 1999 |
Regulation of mda-7 gene expression during human melanoma differentiation.
Topics: 3' Untranslated Regions; Base Sequence; Cell Differentiation; Cloning, Molecular; Cycloheximide; Dactinomycin; Diterpenes; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; Growth Substances; Humans; Interferon-beta; Interleukins; Melanoma; Molecular Sequence Data; Promoter Regions, Genetic; RNA Processing, Post-Transcriptional; RNA Stability; RNA, Messenger; Terpenes | 2000 |
A comparison of the activity, sequence specificity, and CRM1-dependence of different nuclear export signals.
Topics: Amino Acid Sequence; Antibiotics, Antineoplastic; Base Sequence; Breast Neoplasms; Carrier Proteins; Cell Nucleus; Dactinomycin; Databases as Topic; DNA-Binding Proteins; Exportin 1 Protein; Fatty Acids, Unsaturated; Female; Gene Products, rev; Green Fluorescent Proteins; HIV-1; Humans; I-kappa B Proteins; Karyopherins; Luminescent Proteins; Melanoma; Molecular Sequence Data; NF-KappaB Inhibitor alpha; Nuclear Proteins; Proto-Oncogene Proteins c-abl; Receptors, Cytoplasmic and Nuclear; rev Gene Products, Human Immunodeficiency Virus; Sequence Alignment; Sequence Homology, Amino Acid; Templates, Genetic; Tumor Cells, Cultured | 2000 |
p53-independent upregulation of KILLER/DR5 TRAIL receptor expression by glucocorticoids and interferon-gamma.
Topics: Antibiotics, Antineoplastic; Apoptosis; Betulinic Acid; Colonic Neoplasms; Dactinomycin; Dexamethasone; DNA-Binding Proteins; Female; Glioblastoma; Glucocorticoids; Humans; Interferon-gamma; Melanoma; Mutation; Naphthoquinones; Ovarian Neoplasms; Pentacyclic Triterpenes; Prednisolone; Receptors, TNF-Related Apoptosis-Inducing Ligand; Receptors, Tumor Necrosis Factor; RNA, Messenger; STAT1 Transcription Factor; Trans-Activators; Triterpenes; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Up-Regulation | 2001 |
Expression of ring finger-deleted TRAF2 sensitizes metastatic melanoma cells to apoptosis via up-regulation of p38, TNFalpha and suppression of NF-kappaB activities.
Topics: Acetyltransferases; Anisomycin; Apoptosis; Dactinomycin; Gene Expression Regulation, Neoplastic; Humans; Melanoma; Mitogen-Activated Protein Kinases; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Protein Biosynthesis; Proteins; Radiation Tolerance; TNF Receptor-Associated Factor 2; Tumor Necrosis Factor-alpha; Up-Regulation; Zinostatin | 2001 |
Isolated limb infusion for melanoma: a simple alternative to isolated limb perfusion.
Topics: Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Cancer, Regional Perfusion; Dactinomycin; Humans; Infusions, Intra-Arterial; Leg; Melanoma; Melphalan; Skin Neoplasms | 2001 |
Induction of basic helix-loop-helix protein DEC1 (BHLHB2)/Stra13/Sharp2 in response to the cyclic adenosine monophosphate pathway.
Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Chondrocytes; Cyclic AMP; Cycloheximide; Dactinomycin; Dogs; Fibroblasts; Gene Expression; Glioblastoma; HeLa Cells; Helix-Loop-Helix Motifs; Homeodomain Proteins; Humans; Kidney; Lung; Melanoma; Mice; Mice, Inbred BALB C; Parathyroid Hormone; Protein Synthesis Inhibitors; Rabbits; RNA, Messenger; Signal Transduction; Teratocarcinoma | 2001 |
Suppression of macrophage nitric oxide production by melanoma: mediation by a melanoma-derived product.
Topics: Animals; Coculture Techniques; Culture Media, Conditioned; Cycloheximide; Dactinomycin; Dose-Response Relationship, Drug; Female; Macrophages; Macrophages, Peritoneal; Melanoma; Melanoma, Experimental; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Neoplasm Transplantation; Nitric Oxide; Peritoneum; RNA; Time Factors; Tumor Cells, Cultured | 2001 |
[Correlation of in vitro testing and therapeutical results in animal transplanted tumors after cytostatic treatment].
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Bleomycin; Carcinoma 256, Walker; Cricetinae; Dactinomycin; Doxorubicin; In Vitro Techniques; Male; Melanoma; Neoplasm Transplantation; Neoplasms, Experimental; Plasmacytoma; Podophyllin; Rats; Thymidine; Triaziquone; Uridine | 1975 |
Effects of antineoplastic agents on wound healing in mice.
Topics: Animals; Antineoplastic Agents; Bleomycin; Carmustine; Cyclophosphamide; Dactinomycin; Doxorubicin; Fluorouracil; Injections, Intraperitoneal; Male; Melanoma; Methotrexate; Mice; Neoplasms, Experimental; Vincristine; Wound Healing | 1975 |
Hyperthermia in the treatment of cancer.
Topics: Bacillus; Bacterial Toxins; Chemotherapy, Cancer, Regional Perfusion; Dactinomycin; Diathermy; Evaluation Studies as Topic; Hot Temperature; Humans; Hyperthermia, Induced; Immunotherapy; Melanoma; Melphalan; Sarcoma; Skin Neoplasms; Soft Tissue Neoplasms; Streptococcus; X-Ray Therapy | 1979 |
Sensitivity tests of tumors to cytostatic agents. I. Comparative investigations on transplanted tumors in vivo and in vitro.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Carcinoma 256, Walker; Cell Division; Cricetinae; Dactinomycin; Daunorubicin; Dose-Response Relationship, Drug; Doxorubicin; Fluorouracil; In Vitro Techniques; Melanoma; Mice; Mice, Inbred Strains; Neoplasm Transplantation; Neoplasms, Experimental; Plasmacytoma; Procarbazine; Rats; Rats, Inbred ACI; Sarcoma 180; Thymidine; Triaziquone; Uridine | 1975 |
Co-cultivation of tumorigenic mouse melanoma cells with cells of a non-tumorigenic subclone inhibits plasminogen activator expression by the melanoma cells.
Topics: Animals; Bromodeoxyuridine; Cell Division; Cell Fusion; Clone Cells; Dactinomycin; Melanoma; Mice; Mitomycins; Neoplasms, Experimental; Plasminogen Activators; Retroviridae | 1978 |
Actinomycin-D, levamisole chemoimmunotherapy of refractory malignant melanoma.
Topics: Adult; Aged; Dactinomycin; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Levamisole; Male; Melanoma; Middle Aged | 1979 |
Inhibition of DNA synthesis in Harding-Passey melanoma cells by prostaglandins A1 and A2: comparison with chemotherapeutic agents.
Topics: Animals; Antineoplastic Agents; Cyclophosphamide; Dactinomycin; DNA Replication; DNA, Neoplasm; Doxorubicin; Fluorouracil; Hydroxyurea; Kinetics; Melanoma; Mice; Neoplasms, Experimental; Prostaglandins A | 1979 |
A preliminary report of a pilot trial in adjuvant chemotherapy of primary melanoma.
Topics: Antineoplastic Agents; BCG Vaccine; Dacarbazine; Dactinomycin; Drug Therapy, Combination; Female; Humans; Male; Melanoma; Procarbazine; Skin Neoplasms; Vinblastine | 1979 |
Regression of regionally advanced melanoma after arterial infusion with cis-platinum and actinomycin-D.
Topics: Adult; Antineoplastic Agents; Dactinomycin; Female; Humans; Melanoma; Platinum; Propionibacterium acnes; Skin Neoplasms | 1979 |
Chemoimmunotherapy for meningeal melanocytoma of the thoracic spinal cord. Report of a case.
Topics: Aged; Dacarbazine; Dactinomycin; Female; Humans; Immunotherapy; Melanoma; Meningeal Neoplasms; Neoplasm Recurrence, Local; Postoperative Care; Propionibacterium acnes; Spinal Cord Neoplasms | 1979 |
The screening test of various chemotherapeutic drugs in primary malignant melanoma cells and human malignant melanoma cell line (TM-1).
Topics: Aged; Antineoplastic Agents; Cell Line; Cells, Cultured; Dactinomycin; Drug Evaluation, Preclinical; Esophageal Neoplasms; Fluorouracil; Humans; Male; Melanoma; Mitomycins; Skin Neoplasms | 1979 |
Cytotoxics and hyperthermic perfusion: a preliminary study.
Topics: Chemotherapy, Cancer, Regional Perfusion; Dactinomycin; Drug Therapy, Combination; Extremities; Female; Hot Temperature; Humans; Male; Melanoma; Melphalan; Paralysis; Remission, Spontaneous; Sarcoma; Soft Tissue Neoplasms | 1979 |
[Combined chemotherapy of disaeminated melanoma].
Topics: Adult; Aged; Aminoimidazole Carboxamide; Antineoplastic Agents; Dactinomycin; Drug Therapy, Combination; Female; Humans; Lomustine; Male; Melanoma; Methylnitrosourea; Middle Aged; Skin Neoplasms; Vincristine | 1978 |
Melanocyte-stimulating hormone promotes activation of pre-existing tyrosinase molecules in Cloudman S91 melanoma cells.
Topics: Catechol Oxidase; Cell Line; Cycloheximide; Dactinomycin; Enzyme Activation; Melanocyte-Stimulating Hormones; Melanoma; Neoplasm Proteins; Neoplasms, Experimental; RNA, Neoplasm | 1975 |
Synthesis and antitumor activity of 2-deamino- and N2-(gamma-hydroxypropyl)actinomycin D.
Topics: 1-Propanol; Animals; Antineoplastic Agents; Bacillus subtilis; Dactinomycin; Deamination; Leukemia L1210; Leukemia, Experimental; Male; Melanoma; Mice; Microbial Sensitivity Tests; Neoplasms, Experimental; Sarcina; Spectrophotometry; Staphylococcus aureus | 1975 |
Hamster apigmented melanoma as a model for screening of potential antineoplastic drugs.
Topics: Animals; Antineoplastic Agents; Cricetinae; Cyclophosphamide; Dactinomycin; Drug Evaluation, Preclinical; Melanoma; Mercaptopurine; Neoplasms, Experimental; Skin Neoplasms; Vinblastine | 1977 |
Pharmacokinetics of actinoymcin D in patients with malignant melanoma.
Topics: Adult; Aged; Blood-Brain Barrier; Bone Marrow; Bone Marrow Cells; Chromatography, Thin Layer; Dactinomycin; Electrophoresis, Paper; Feces; Female; Half-Life; Humans; Injections, Intravenous; Kinetics; Male; Melanoma; Middle Aged; Tritium | 1975 |
Multimodality therapy in the treatment of regionally inoperable melanomas and sarcomas.
Topics: Adult; Aged; BCG Vaccine; Chemotherapy, Cancer, Regional Perfusion; Dacarbazine; Dactinomycin; Female; Humans; Lymphatic Metastasis; Male; Melanoma; Melphalan; Middle Aged; Sarcoma | 1975 |
Chemotherapy of melanoma.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents; Carmustine; Cyclophosphamide; Dacarbazine; Dactinomycin; Drug Therapy, Combination; Female; Humans; Hydroxyurea; Male; Melanoma; Middle Aged; Neoplasm Metastasis; Nitrosourea Compounds; Semustine; Skin Neoplasms; Vinca Alkaloids | 1975 |
Ameloblastic sarcoma: pathogenesis and treatment with chemotherapy.
Topics: Adult; Antineoplastic Agents; Cyclophosphamide; Dactinomycin; Drug Therapy, Combination; Head and Neck Neoplasms; Humans; Jaw Neoplasms; Male; Melanoma; Neoplasm Recurrence, Local; Neoplasms, Multiple Primary; Odontogenic Tumors; Vincristine | 1976 |
A pharmacokinetically based phase I-II study of single-dose actinomycin D (NSC-3053).
Topics: Agranulocytosis; Animals; Biological Availability; Breast Neoplasms; Dactinomycin; Dogs; Half-Life; Humans; Melanoma; Mice; Neoplasm Metastasis; Sarcoma | 1976 |
[The sensitivity of human melanoma heterotransplants to chemotherapeutic action].
Topics: Animals; Antineoplastic Agents; Dactinomycin; Drug Therapy, Combination; Melanoma; Methylnitrosourea; Mice; Neoplasm Transplantation; Transplantation, Heterologous; Vinblastine; Vincristine | 1976 |
Interleukin-1-inducible tumor growth arrest is characterized by activation of cell type-specific "early" gene expression programs.
Topics: Cell Division; Cell Line; Dactinomycin; DNA Replication; DNA, Neoplasm; Gene Expression Regulation, Neoplastic; Gene Library; Genes, Regulator; Humans; Interleukin-1; Interleukin-6; Kinetics; Melanoma; Poly A; Proto-Oncogenes; Recombinant Proteins; RNA; RNA, Messenger; Thymidine; Time Factors; Transcriptional Activation; Tumor Necrosis Factor-alpha | 1992 |
Regulation of the 202 gene expression by interferons in L929 cells.
Topics: 2',5'-Oligoadenylate Synthetase; Animals; Blotting, Northern; Cell Line; Cycloheximide; Dactinomycin; Fibroblasts; Gene Expression Regulation; Interferon Type I; Interferon-gamma; Interferons; Melanoma; RNA, Messenger; Teratoma; Tumor Cells, Cultured | 1992 |
The role of hyperthermic perfusion in the treatment of tumors of the extremities.
Topics: Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Cancer, Regional Perfusion; Cisplatin; Dactinomycin; Extracorporeal Circulation; Extremities; Humans; Hyperthermia, Induced; Melanoma; Melphalan; Neoplasm Recurrence, Local; Osteosarcoma; Sarcoma; Soft Tissue Neoplasms; Survival Rate | 1990 |
Development of mitoxantrone.
Topics: Animals; Anthraquinones; Antineoplastic Agents; Cell Line; Chemistry, Pharmaceutical; Colonic Neoplasms; Cricetinae; Cricetulus; Dactinomycin; DNA; Doxorubicin; Drug Evaluation; Drug Synergism; Female; Heart; Humans; Intercalating Agents; Interphase; Leukemia L1210; Leukemia P388; Melanoma; Mice; Mitoxantrone; RNA; RNA, Double-Stranded; Structure-Activity Relationship | 1985 |
Phase II study of bleomycin, actinomycin D, DTIC and vindesine in disseminated malignant melanoma.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Dacarbazine; Dactinomycin; Drug Evaluation; Female; Humans; Lung Neoplasms; Male; Melanoma; Middle Aged; Vindesine | 1986 |
In vitro modulation of proliferation and melanization of S91 melanoma cells by prostaglandins.
Topics: 1-Methyl-3-isobutylxanthine; Alprostadil; Bucladesine; Cell Division; Cycloheximide; Dactinomycin; Dinoprostone; In Vitro Techniques; Melanins; Melanoma; Monophenol Monooxygenase; Prostaglandin D2; Prostaglandins; Prostaglandins A; Prostaglandins D; Prostaglandins E | 1987 |
Spermidine level as a parameter in the treatment of patients with malignant melanoma.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Dacarbazine; Dactinomycin; Drug Administration Schedule; Female; Humans; Male; Melanoma; Middle Aged; Spermidine; Vinblastine; Vindesine | 1985 |
"Reverse" and "symmetrical" analogues of actinomycin D: metabolic activation and in vitro and in vivo tumor growth inhibitory activities.
Topics: Animals; Biotransformation; Cattle; Chemical Phenomena; Chemistry, Physical; Dactinomycin; DNA; DNA, Neoplasm; Free Radicals; In Vitro Techniques; Leukemia P388; Male; Melanoma; Mice; Microsomes, Liver; NADP; Oxidation-Reduction; Rats; RNA, Neoplasm; Sonication; Superoxides | 1985 |
Cytostatic and cytotoxic activity of tumor necrosis factor on human cancer cells.
Topics: Breast Neoplasms; Cell Division; Cell Line; Cell Survival; Colonic Neoplasms; Cycloheximide; Cytotoxins; Dactinomycin; Female; Glycoproteins; Humans; Interferon-gamma; Melanoma; Neoplasm Proteins; Receptors, Cell Surface; Receptors, Tumor Necrosis Factor; Recombinant Proteins; Tumor Necrosis Factor-alpha; Uterine Cervical Neoplasms | 1987 |
Regulation of cell shape in the Cloudman melanoma cell line.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; alpha-MSH; Animals; Axons; Cell Line; Cyclic AMP; Cycloheximide; Dactinomycin; Fluorescent Antibody Technique; Isoquinolines; Melanocyte-Stimulating Hormones; Melanoma; Mice; Microscopy, Electron; Piperazines; Protein Kinase C; Sulfonamides; Tetradecanoylphorbol Acetate; Time Factors; Transcription, Genetic | 1987 |
Induction of 32- and 34-kDa stress proteins by sodium arsenite, heavy metals, and thiol-reactive agents.
Topics: Amino Acids; Animals; Arsenic; Arsenites; Cadmium; Calcimycin; Chloromercuribenzoates; Copper; Cycloheximide; Dactinomycin; Heat-Shock Proteins; Hot Temperature; Humans; Iodoacetamide; Melanoma; Metals; Mice; Molecular Weight; Sodium Compounds; Sulfhydryl Reagents; Zinc | 1986 |
Triiodothyronine repression of imidazole-induced tyrosinase expression in B16 melanoma cells.
Topics: Animals; Catechol Oxidase; Cell Division; Cell Line; Dactinomycin; Dose-Response Relationship, Drug; Imidazoles; Melanoma; Mice; Monophenol Monooxygenase; RNA, Messenger; Triiodothyronine; Triiodothyronine, Reverse | 1986 |
Characterization of a monoclonal antibody-defined human melanoma-associated antigen susceptible to induction by immune interferon.
Topics: Antibodies, Monoclonal; Antibody Specificity; Antigens, Neoplasm; Carcinoma; Cell Line; Dactinomycin; Glycoproteins; Humans; Interferon-gamma; Melanoma; Molecular Weight; Puromycin | 1987 |
Inhibition of imidazole-induced tyrosinase activity by estradiol and estriol in cultured B16/C3 melanoma cells.
Topics: Animals; Catechol Oxidase; Cell Division; Dactinomycin; Dose-Response Relationship, Drug; Enzyme Induction; Estradiol; Estriol; Imidazoles; Melanoma; Monophenol Monooxygenase; Protein Biosynthesis; RNA, Messenger; Tumor Cells, Cultured | 1988 |
[Combined treatment of patients with metastases of skin melanoma using cryotherapy].
Topics: Aminoimidazole Carboxamide; Antineoplastic Combined Chemotherapy Protocols; BCG Vaccine; Combined Modality Therapy; Cryosurgery; Dactinomycin; Female; Humans; Immunotherapy; Male; Melanoma; Neoplasm Metastasis; Prospidium; Skin Neoplasms; Vincristine | 1988 |
[Late results of the conservative treatment of melanoma of the skin].
Topics: Antineoplastic Combined Chemotherapy Protocols; Dacarbazine; Dactinomycin; Humans; Melanoma; Skin Neoplasms; Vincristine | 1986 |
Structural changes in nucleoli during inhibition of protein- and RNA-biosynthesis.
Topics: Adult; Cell Line; Cell Nucleolus; Cells, Cultured; Dactinomycin; Female; Fibroblasts; HeLa Cells; Humans; Lymphocytes; Male; Melanoma; Microscopy, Electron; Middle Aged; Protein Biosynthesis; Puromycin; Skin; Transcription, Genetic | 1987 |
[The effect of actinomycin D on the survival and recoverability of irradiated human melanoma cells].
Topics: Cells, Cultured; Combined Modality Therapy; Dactinomycin; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Humans; Melanoma; Radiation Tolerance | 1987 |
Phase II evaluation of dibromodulcitol and actinomycin D, hydroxyurea, and cyclophosphamide in previously untreated patients with malignant melanoma.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Dactinomycin; Drug Evaluation; Female; Humans; Hydroxyurea; Male; Melanoma; Middle Aged; Mitolactol; Semustine | 1987 |
Phase II study: the combination DTIC, BCNU, actinomycin D, and vincristine in disseminated malignant melanoma.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Dacarbazine; Dactinomycin; Drug Evaluation; Female; Humans; Male; Melanoma; Middle Aged; Vincristine | 1986 |
Dibromodulcitol (DBD), DTIC, and actinomycin-D in disseminated malignant melanoma. A phase I-II clinical trial.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Dacarbazine; Dactinomycin; Drug Evaluation; Female; Gastrointestinal Diseases; Hematologic Diseases; Humans; Male; Melanoma; Middle Aged; Mitolactol | 1985 |
Quantitative cytochemical analysis by microdensitometry of spontaneous or alpha-MSH-stimulated melanogenesis in B16 melanoma cells cultivated in vitro.
Topics: Animals; Cell Division; Cells, Cultured; Cycloheximide; Dactinomycin; Densitometry; Melanins; Melanocyte-Stimulating Hormones; Melanoma; Mice; Mice, Inbred C57BL; Monophenol Monooxygenase; Phenylthiourea | 1985 |
Single-dose dacarbazine and dactinomycin in advanced malignant melanoma.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Dacarbazine; Dactinomycin; Female; Humans; Leukocyte Count; Male; Melanoma; Middle Aged; Neoplasm Metastasis; Platelet Count; Urinary Tract Infections | 1985 |
Macrophage-melanoma cell heterokaryons. 3. The activation of macrophage DNA synthesis. Studies with inhibitors of protein synthesis and with synchronized melanoma cells.
Topics: Animals; Anti-Bacterial Agents; Cell Fusion; Cell Nucleus; Cells, Cultured; Cyclohexanes; Cycloheximide; Dactinomycin; DNA; Histocytochemistry; Leucine; Macrophages; Melanoma; Mice; Mitosis; Neoplasm Proteins; Neoplasms, Experimental; Peritoneum; Protein Biosynthesis; Pyridones; RNA, Neoplasm; Thymidine; Tritium; Uridine | 1971 |
Primary malignant melanoma of the esophagus: an electron microscopic study.
Topics: Aged; Carcinosarcoma; Dactinomycin; Esophageal Neoplasms; Esophagoscopy; Female; Humans; Leiomyosarcoma; Melanoma; Microscopy, Electron; Nitrosourea Compounds; Staining and Labeling; Vincristine | 1972 |
[Histochemical data on human skin melanoma in relation to treatment].
Topics: Chemotherapy, Cancer, Regional Perfusion; Clinical Enzyme Tests; Dactinomycin; Flavonoids; Histocytochemistry; Humans; Melanoma; Melphalan; NADH, NADPH Oxidoreductases; Oxidoreductases; Phosphoric Monoester Hydrolases; Radiotherapy Dosage; Skin Neoplasms; Time Factors | 1974 |
Oncorna-viral information in human melanoma.
Topics: Brain Neoplasms; Dactinomycin; DNA Nucleotidyltransferases; Ethidium; Humans; Lymphatic Metastasis; Melanoma; Microsomes; Neoplasm Metastasis; Oncogenic Viruses; RNA Viruses; RNA-Directed DNA Polymerase; RNA, Viral; Subcellular Fractions | 1974 |
Effect of mitomycin C on protein synthesis in human neoplastic cell lines.
Topics: Alanine; Astrocytoma; Dactinomycin; Humans; In Vitro Techniques; Lysine; Melanoma; Mitomycins; Neoplasm Proteins; Protein Hydrolysates; Puromycin; Tyrosine | 1965 |
Some aspects of the use of cytostatic drugs in dermatology.
Topics: Colchicine; Dactinomycin; Fluorouracil; Humans; Melanoma; Methotrexate; Mycosis Fungoides; Nitrogen Mustard Compounds; Psoriasis; Sarcoma, Kaposi; Skin Neoplasms; Vinblastine | 1966 |
[To the problem of the stimulation of the growth of transplantable tumors of animals previously treated with antineoplastic antibiotics].
Topics: Animals; Antibiotics, Antineoplastic; Dactinomycin; Male; Melanoma; Mice; Neoplasm Transplantation; Neoplasms, Experimental; Olivomycins; Rats; Sarcoma; Sarcoma 37 | 1968 |
[Combined action of roentgen radiation and antineoplastic antibiotics (chrysomallin, olivomycin) on the transplantable tumors of animals].
Topics: Animals; Antibiotics, Antineoplastic; Dactinomycin; Male; Melanoma; Mice; Neoplasm Transplantation; Neoplasms, Experimental; Olivomycins; Rats; Sarcoma | 1968 |
[On the use of antineoplastic antibiotics in the complex therapy of melanoma metastases].
Topics: Adult; Antibiotics, Antineoplastic; Dactinomycin; Female; Flavonoids; Humans; Leukopenia; Lymphatic Metastasis; Male; Melanoma; Middle Aged; Olivomycins; Radiation-Sensitizing Agents; Skin Neoplasms | 1969 |
[Use of chrysomallin in complex treatment of melanoblastomas].
Topics: Adolescent; Adult; Aged; Dactinomycin; Female; Humans; Male; Melanoma; Middle Aged; Neoplasm Metastasis; Skin Neoplasms | 1968 |
[Injury of bone marrow after local irradiation of tumor and administration of chrysomalline].
Topics: Animals; Bone Marrow; Bone Marrow Cells; Dactinomycin; Male; Melanoma; Mice; Neoplasm Transplantation; Neoplasms, Experimental; Radiation Effects | 1969 |
Change in cell-to-dish contact of cultured mammalian cells induced by concanavalin A.
Topics: Animals; Binding Sites; Calcium; Cell Aggregation; Cell Line; Concanavalin A; Contact Inhibition; Cycloheximide; Dactinomycin; Dinitrophenols; Drug Resistance; Edetic Acid; Hyaluronoglucosaminidase; Kinetics; Magnesium; Mannose; Melanoma; Methylglycosides; Mice; Neuraminidase; Pronase; Temperature; Time Factors; Trypsin | 1974 |
[Apropos of an experience with the polychemotherapy of cancer].
Topics: Adult; Bone Neoplasms; Child; Chlorambucil; Cyclophosphamide; Dactinomycin; Drug Synergism; Dysgerminoma; Female; Fibrosarcoma; Humans; Male; Melanoma; Mesothelioma; Methotrexate; Middle Aged; Myxosarcoma; Neoplasms, Connective Tissue; Neoplasms, Germ Cell and Embryonal; Neurilemmoma; Neurofibromatosis 1; Ovarian Neoplasms; Rhabdomyosarcoma; Testicular Neoplasms; Uterine Neoplasms | 1968 |
[Results of cooperative clinical studies of the antineoplastic antibiotic dactinomycin].
Topics: Adolescent; Adult; Bone Neoplasms; Child; Child, Preschool; Choriocarcinoma; Dactinomycin; Female; Hodgkin Disease; Humans; Infant; Laryngeal Neoplasms; Lung Neoplasms; Lymphoma, Large B-Cell, Diffuse; Male; Melanoma; Middle Aged; Pregnancy; Urinary Bladder Neoplasms; Uterine Neoplasms; Wilms Tumor | 1972 |
Control of phenotypic expression of cultured melanoma cells by melanocyte stimulating hormones.
Topics: Animals; Butyrates; Catechol Oxidase; Cell Division; Cell Line; Cyclic AMP; Cycloheximide; Dactinomycin; DNA, Neoplasm; Melanins; Melanocyte-Stimulating Hormones; Melanoma; Mice; Neoplasms, Experimental; Phenotype; Protein Biosynthesis; RNA, Neoplasm; Transcription, Genetic; Tritium | 1973 |
Combination therapy: some concepts and results.
Topics: Animals; Antineoplastic Agents; Child; Cyclohexanes; Cyclophosphamide; Cytarabine; Dactinomycin; Drug Resistance; Drug Synergism; Drug Therapy, Combination; Humans; Imidazoles; Leukemia L1210; Lung Neoplasms; Melanoma; Mice; Neoplasm Metastasis; Neoplasms; Neoplasms, Experimental; Nitrogen Mustard Compounds; Nitrosourea Compounds; Thioguanine; Triazenes; Wilms Tumor | 1974 |
Results in 169 patients with cancer of the head and neck treated by intra-arterial infusion therapy.
Topics: Antineoplastic Agents; Brachial Artery; Brachiocephalic Trunk; Carcinoma, Squamous Cell; Carotid Artery, Internal; Catheterization; Cyclophosphamide; Dactinomycin; Fluorouracil; Head; Head and Neck Neoplasms; Humans; Injections, Intra-Arterial; Laryngeal Neoplasms; Melanoma; Methods; Methotrexate; Mouth Neoplasms; Neoplasms; Osteosarcoma; Paranasal Sinus Neoplasms; Pharyngeal Neoplasms; Skin Neoplasms; Skull Neoplasms; Vinblastine | 1972 |
Perfusion of melanoma. 105 isolated perfusions in 92 patients.
Topics: Chemotherapy, Cancer, Regional Perfusion; Dactinomycin; Humans; Melanoma; Melphalan; Neoplasm Recurrence, Local; Skin Neoplasms; Thiotepa | 1972 |
Local and systemic immunologic effects of perfusion therapy for malignant melanoma.
Topics: Antigens, Neoplasm; Antineoplastic Agents; Chemotherapy, Cancer, Regional Perfusion; Dactinomycin; Extremities; Graft Rejection; Humans; Immunosuppression Therapy; Lectins; Lymphocyte Activation; Lymphocyte Depletion; Lymphocytes; Mechlorethamine; Melanoma; Melphalan; Prognosis; Streptolysins; Stress, Physiological | 1973 |
Chemotherapy of disseminated malignant melanoma with dimethyl triazeno imidazole carboxamide and dactinomycin.
Topics: Adult; Aged; Amides; Antineoplastic Agents; Brain Neoplasms; Cerebral Hemorrhage; Dactinomycin; Drug Therapy, Combination; Evaluation Studies as Topic; Female; Humans; Imidazoles; Male; Melanoma; Middle Aged; Neoplasm Metastasis; Triazenes | 1973 |
Investigational drugs for the treatment of malignant melanoma.
Topics: Alkylating Agents; Amides; Anorexia Nervosa; Antineoplastic Agents; Cyclophosphamide; Dactinomycin; Drug Combinations; Humans; Hydroxyurea; Imidazoles; Leukopenia; Melanoma; Nausea; Thrombocytopenia; Vomiting | 1974 |
[Practical treatment of malignant melanoma].
Topics: Adult; Dactinomycin; Facial Neoplasms; Female; Humans; Melanoma; Nevus; Skin Neoplasms; Thiotepa | 1970 |
[Chemotherapy of solid tumors].
Topics: Antineoplastic Agents; Child; Chlorambucil; Cyclophosphamide; Dactinomycin; Drug Synergism; Fluorouracil; Humans; Melanoma; Methotrexate; Neoplasms; Nitrogen Mustard Compounds; Skin Neoplasms; Thiotepa | 1970 |
[Study of the distribution of C14 dactinomycin in the body of intact mice and mice with lymphosarcoma LIO-1 and melanoma Harding-Passey].
Topics: Animals; Dactinomycin; Injections, Intravenous; Kidney; Liver; Lymphoma, Non-Hodgkin; Melanoma; Mice; Neoplasms, Experimental; Radiometry; Spleen; Time Factors | 1971 |
Advanced melanoma of the extremities.
Topics: Adolescent; Adult; Aged; Chemotherapy, Cancer, Regional Perfusion; Child; Dactinomycin; Female; Humans; Leg; Male; Mechlorethamine; Melanoma; Melphalan; Middle Aged; Neoplasm Metastasis; Prognosis; Skin Neoplasms | 1970 |
Local chemotherapy of cutaneous neoplasms.
Topics: Adenocarcinoma; Allergy and Immunology; Antineoplastic Agents; Carcinoma, Squamous Cell; Dactinomycin; Fibrosarcoma; Fluorouracil; Humans; Hypersensitivity; Leukemia; Lymphoma; Melanoma; Methotrexate; Nitrogen Mustard Compounds; Skin Neoplasms; Triaziquone | 1970 |
Combined actinomycin D and vincristine in the treatment of patients with cancer.
Topics: Breast Neoplasms; Dactinomycin; Humans; Lung Neoplasms; Melanoma; Neoplasms; Sarcoma; Vincristine | 1971 |
Hyperthermic perfusion with chemotherapy for cancers of the extremities.
Topics: Arm; Burns; Chemotherapy, Cancer, Regional Perfusion; Dactinomycin; Edema; Femoral Neoplasms; Foot Diseases; Hemangiosarcoma; Hemoglobinuria; Hemolysis; Hot Temperature; Humans; Leg; Melanoma; Melphalan; Neoplasm Metastasis; Sarcoma; Sarcoma, Ewing; Sarcoma, Kaposi; Time Factors | 1969 |