dactinomycin and Acute Liver Injury, Drug-Induced

dactinomycin has been researched along with Acute Liver Injury, Drug-Induced in 52 studies

Research

Studies (52)

Timeframe	Studies, this research(%)	All Research%
pre-1990	27 (51.92)	18.7374
1990's	7 (13.46)	18.2507
2000's	5 (9.62)	29.6817
2010's	11 (21.15)	24.3611
2020's	2 (3.85)	2.80

Authors

Authors	Studies
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Ding, D; Fang, H; Kelly, R; Liu, Z; Shi, Q; Tong, W	1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
An, R; Hao, J; Xue, Y; Yu, H; Zhang, M; Zhang, T; Zhou, W	1
Han, Z; Jia, FJ; Jiang, SQ; Li, X; Ma, JH; Ruan, H; Xie, WD; Zhao, XM	1
Li, Q; Ma, Y; Mu, X; Song, L; Wang, D; Yin, R; Zhao, X	1
Boddy, AV; Bonner, JJ; Ghazaly, EA; Gribben, JG; Johnson, TN; Neuhoff, S; Veal, GJ; Walsh, C	1
Ando, R; Imaizumi, M; Nio, M; Sato, A; Sato, T; Shimanuki, Y; Takeyama, J	1
Erhardt, A; Haimerl, F; Sass, G; Tiegs, G	1
D'Angelo, P; Di Marco, F; Farruggia, P; Grigoli, A; Macaluso, A; Russo, D; Trizzino, A; Tropia, S	1
Arndt, CA; Barrett, JS; Langholz, B; Renbarger, J; Seibel, NL; Skolnik, JM; Zajicek, A	1
Carboné, A; Garcia-Iñiguez, JP; Madurga, P; Martín-Lázaro, JF; Palanca, D	1
VORBRODT, K	1
Anderson, JR; Arndt, C; Breitfeld, P; Hawkins, D; Meyer, W; Womer, R	1
Lv, W; Mao, Y; Wan, X; Xie, X	1
Blake, DA; Cascorbi, HF; Krantz, JC; Rozman, RS	1
Berkowitz, RS; Bernstein, MR; Goldstein, DP	2
Sidransky, H; Verney, E	1
Leist, M; Wendel, A	1
Iitsuka, Y; Matsui, H; Seki, K; Sekiya, S	1
Brouckaert, P; Libert, C; Van Molle, W; Vanden Berghe, J	1
Ekert, H; McVeagh, P	1
Jayabose, S; Lanzkowsky, P; Shende, A	1
Altmann, HW; Knobloch, U; Romen, W	1
Mihevc-Srakar, N; Petrić-Grabnar, G	1
Faus, MJ; Lupiáñez, A; Sánchez-Medina, F; Vargas, A	1
Anders, MW; Lindstrom, TD	1
Hida, S; Nishimura, K; Nishio, Y; Oishi, K; Takeuchi, H; Yoshida, O	1
Bowman, A; Pritchard, J; Raine, J; Wallendszus, K	1
Breslow, NE; D'Angio, GJ; Finklestein, JZ; Green, DM; Norkool, P	1
Horn, M; Ruchelli, ED; Taylor, SR	1
Chevallier, B; Devictor, D; Lagardère, B; Treluyer, JM; Yaiche, MC	1
Pritchard, J; Raine, J; Wallendszus, K	1
D'Angio, GJ	2
D'Angio, GJ; Finklestein, JZ; Green, DM; Norkool, P	1
Bailey, CC; Choonara, IA; Kendall-Smith, S	1
Engelmann, C; Konrad, H; Zubaidi, G	1
Chiga, M; Kume, F	1
Miyaki, K; Terao, K	1
Balzereit, F; Leipert, M; Mertens, HG	1
Della Corte, E; Stirpe, F	1
Bumpus, FM; Sen, S; Smeby, RR	1
Friedman, MA; Wogan, GN	1
Gravela, E	1
Indacochea-Redmond, N; Plaa, GL; Witschi, H	1
Berezina, EK; Shtegel'man, LA; Zhukov, VG	1

Reviews

2 review(s) available for dactinomycin and Acute Liver Injury, Drug-Induced

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Direct comparisons of efficacy and safety between actinomycin-D and methotrexate in women with low-risk gestational trophoblastic neoplasia: a meta-analysis of randomized and high-quality non-randomized studies. BMC cancer, 2021, Oct-18, Volume: 21, Issue:1 Topics: Alopecia; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Chemical and Drug Induced Liver Injury; Dactinomycin; Female; Gestational Trophoblastic Disease; Humans; Methotrexate; Nausea; Pregnancy; Randomized Controlled Trials as Topic; Remission Induction; Risk; Treatment Outcome; Vomiting	2021

Article

Year

DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.

Drug discovery today, 2016, Volume: 21, Issue:4

Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Direct comparisons of efficacy and safety between actinomycin-D and methotrexate in women with low-risk gestational trophoblastic neoplasia: a meta-analysis of randomized and high-quality non-randomized studies.

BMC cancer, 2021, Oct-18, Volume: 21, Issue:1

Topics: Alopecia; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Chemical and Drug Induced Liver Injury; Dactinomycin; Female; Gestational Trophoblastic Disease; Humans; Methotrexate; Nausea; Pregnancy; Randomized Controlled Trials as Topic; Remission Induction; Risk; Treatment Outcome; Vomiting

2021

Trials

6 trial(s) available for dactinomycin and Acute Liver Injury, Drug-Induced

Article	Year
Age is a risk factor for chemotherapy-induced hepatopathy with vincristine, dactinomycin, and cyclophosphamide. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2004, May-15, Volume: 22, Issue:10 Topics: Age Factors; Antineoplastic Combined Chemotherapy Protocols; Chemical and Drug Induced Liver Injury; Child, Preschool; Cyclophosphamide; Dactinomycin; Female; Humans; Incidence; Infant; Male; Prospective Studies; Randomized Controlled Trials as Topic; Rhabdomyosarcoma; Risk Factors; United States; Vincristine	2004
Relapsed or refractory gestational trophoblastic neoplasia treated with the etoposide and cisplatin/etoposide, methotrexate, and actinomycin D (EP-EMA) regimen. International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 2007, Volume: 98, Issue:1 Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Diseases; Chemical and Drug Induced Liver Injury; Cisplatin; Cyclophosphamide; Dactinomycin; Dose-Response Relationship, Drug; Etoposide; Female; Follow-Up Studies; Gestational Trophoblastic Disease; Humans; Methotrexate; Middle Aged; Neoplasm Recurrence, Local; Pregnancy; Pregnancy Outcome; Remission Induction; Retrospective Studies; Salvage Therapy; Treatment Outcome; Vincristine	2007
Severe hepatic toxicity after treatment with vincristine and dactinomycin using single-dose or divided-dose schedules: a report from the National Wilms' Tumor Study. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1990, Volume: 8, Issue:9 Topics: Antineoplastic Combined Chemotherapy Protocols; Chemical and Drug Induced Liver Injury; Child, Preschool; Combined Modality Therapy; Dactinomycin; Drug Administration Schedule; Female; Humans; Infant; Kidney Neoplasms; Liver Diseases; Liver Function Tests; Male; Randomized Controlled Trials as Topic; Vincristine; Wilms Tumor	1990
Unexpected toxicity encountered in the National Wilms' Tumor Study. Cancer treatment reports, 1987, Volume: 71, Issue:10 Topics: Antineoplastic Combined Chemotherapy Protocols; Chemical and Drug Induced Liver Injury; Child; Clinical Trials as Topic; Dactinomycin; Drug Administration Schedule; Humans; Kidney Neoplasms; Vincristine; Wilms Tumor	1987
Severe hepatic toxicity after treatment with single-dose dactinomycin and vincristine. A report of the National Wilms' Tumor Study. Cancer, 1988, Jul-15, Volume: 62, Issue:2 Topics: Antineoplastic Combined Chemotherapy Protocols; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Dactinomycin; Female; Humans; Infant; Kidney Neoplasms; Male; Vincristine; Wilms Tumor	1988
Hepatotoxicity with actinomycin D. Lancet (London, England), 1987, Jul-11, Volume: 2, Issue:8550 Topics: Chemical and Drug Induced Liver Injury; Child; Clinical Trials as Topic; Dactinomycin; Humans; Random Allocation; Risk; Wilms Tumor	1987

Other Studies

44 other study(ies) available for dactinomycin and Acute Liver Injury, Drug-Induced

Article	Year
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). PLoS computational biology, 2011, Volume: 7, Issue:12 Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Databases, Factual; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Models, Biological; Predictive Value of Tests	2011
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
Involvement of Reactive Oxygen Species in the Hepatorenal Toxicity of Actinomycin V In Vitro and In Vivo. Marine drugs, 2020, Aug-15, Volume: 18, Issue:8 Topics: Animals; Antibiotics, Antineoplastic; Chemical and Drug Induced Liver Injury; Dactinomycin; Dose-Response Relationship, Drug; HEK293 Cells; Humans; Kidney; Kidney Diseases; Lipid Peroxidation; Liver; Male; Mice; Oxidative Stress; Reactive Oxygen Species	2020
Hepatic toxicity following actinomycin D chemotherapy in treatment of familial gestational trophoblastic neoplasia: A case report. Medicine, 2018, Volume: 97, Issue:38 Topics: Adaptor Proteins, Signal Transducing; Administration, Intravenous; Antibiotics, Antineoplastic; Asian People; Chemical and Drug Induced Liver Injury; Chorionic Gonadotropin, beta Subunit, Human; Dactinomycin; Drug-Related Side Effects and Adverse Reactions; Female; Gestational Trophoblastic Disease; Humans; Hypolipidemic Agents; Liver; Lung Neoplasms; Mutation; Neoplasm Staging; Phosphatidylcholines; Pregnancy; Proteins; Saponins; Tomography, X-Ray Computed; Treatment Outcome; Triterpenes; Young Adult	2018
Development of a physiologically based pharmacokinetic model of actinomycin D in children with cancer. British journal of clinical pharmacology, 2016, Volume: 81, Issue:5 Topics: Adolescent; Adult; Animals; Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Cohort Studies; Computer Simulation; Dactinomycin; Dogs; Female; Humans; Infant; Madin Darby Canine Kidney Cells; Male; Models, Biological; Neoplasms; Young Adult	2016
Focal nodular hyperplasia-like lesion of the liver in a child previously treated for nephroblastoma. Pathology international, 2008, Volume: 58, Issue:9 Topics: Antineoplastic Combined Chemotherapy Protocols; Chemical and Drug Induced Liver Injury; Child; Combined Modality Therapy; Dactinomycin; Focal Nodular Hyperplasia; Humans; Kidney Neoplasms; Magnetic Resonance Imaging; Male; Nephrectomy; Vincristine; Wilms Tumor	2008
Down-regulation of the de-ubiquitinating enzyme ubiquitin-specific protease 2 contributes to tumor necrosis factor-alpha-induced hepatocyte survival. The Journal of biological chemistry, 2009, Jan-02, Volume: 284, Issue:1 Topics: Animals; Apoptosis; CASP8 and FADD-Like Apoptosis Regulating Protein; Cell Survival; Chemical and Drug Induced Liver Injury; Dactinomycin; Down-Regulation; Endopeptidases; Gene Expression Regulation, Enzymologic; Hepatocytes; JNK Mitogen-Activated Protein Kinases; Liver; MAP Kinase Signaling System; Mice; Mice, Inbred BALB C; p38 Mitogen-Activated Protein Kinases; Protein Synthesis Inhibitors; RNA, Small Interfering; Tumor Necrosis Factor-alpha; Ubiquitin Thiolesterase; Ubiquitin-Protein Ligases; Ubiquitin-Specific Proteases	2009
Hepatopathy-thrombocytopenia syndrome (HTS) after actinomycin-D therapy: report of three cases and review of the literature. Pediatric hematology and oncology, 2011, Volume: 28, Issue:3 Topics: Antibiotics, Antineoplastic; Chemical and Drug Induced Liver Injury; Dactinomycin; Female; Humans; Infant; Kidney Neoplasms; Male; Review Literature as Topic; Syndrome; Thrombocytopenia; Wilms Tumor	2011
Dactinomycin and vincristine toxicity in the treatment of childhood cancer: a retrospective study from the Children's Oncology Group. Pediatric blood & cancer, 2011, Volume: 57, Issue:2 Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Dactinomycin; Dose-Response Relationship, Drug; Female; Humans; Infant; Kaplan-Meier Estimate; Kidney Neoplasms; Likelihood Functions; Male; Neurotoxicity Syndromes; Proportional Hazards Models; Retrospective Studies; Rhabdomyosarcoma; Risk Factors; Vincristine; Wilms Tumor	2011
Hepatopathy-thrombocytopenia syndrome after actinomycin-D therapy: treatment with defibrotide. Pediatric hematology and oncology, 2013, Volume: 30, Issue:1 Topics: Adolescent; Chemical and Drug Induced Liver Injury; Compassionate Use Trials; Dactinomycin; Female; Humans; Polydeoxyribonucleotides; Syndrome; Thrombocytopenia; Wilms Tumor	2013
CYTOCHEMICAL AND CYTOPHOTOMETRIC STUDIES ON THE EFFECT OF ACTINOMYCIN D ON THE CELLS OF THE REGENERATING LIVER OF A RAT POISONED WITH THIOACETAMIDE. Bulletin de l'Academie polonaise des sciences. Serie des sciences biologiques, 1965, Volume: 13 Topics: Chemical and Drug Induced Liver Injury; Cytoplasm; Dactinomycin; Hepatitis; Liver Regeneration; Rats; Thioacetamide; Toxicology	1965
Anesthesia. LXXIV. Biotransformation of fluroxene. I. Metabolism in mice and dogs in vivo. Biochemical pharmacology, 1967, Jul-07, Volume: 16, Issue:7 Topics: Animals; Benzopyrenes; Biotransformation; Carbon Isotopes; Chemical and Drug Induced Liver Injury; Dactinomycin; Dogs; Ethers; Ethyl Ethers; Ethylamines; Female; Male; Methylcholanthrene; Mice; Nitrous Oxide; Phenobarbital; Proadifen	1967
Modified triple chemotherapy in the management of high-risk metastatic gestational trophoblastic tumors. Gynecologic oncology, 1984, Volume: 19, Issue:2 Topics: Adolescent; Adult; Agranulocytosis; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Chemical and Drug Induced Liver Injury; Chorionic Gonadotropin; Cisplatin; Cyclophosphamide; Dactinomycin; Drug Evaluation; Drug Therapy, Combination; Female; Humans; Leucovorin; Methotrexate; Middle Aged; Neoplasm Metastasis; Pregnancy; Pregnancy Complications, Neoplastic; Risk; Thrombocytopenia; Trophoblastic Neoplasms; Uterine Neoplasms; Vinblastine	1984
Methotrexate with citrovorum factor rescue as primary therapy for gestational trophoblastic disease. Cancer, 1982, Nov-15, Volume: 50, Issue:10 Topics: Adolescent; Adult; Agranulocytosis; Chemical and Drug Induced Liver Injury; Dactinomycin; Drug Therapy, Combination; Female; Humans; Leucovorin; Methotrexate; Middle Aged; Neoplasm Metastasis; Pregnancy; Thrombocytopenia; Trophoblastic Neoplasms; Uterine Neoplasms	1982
Acute effects of selected hepatotoxic agents on polyribosomes and protein synthesis in the livers of rats fed purified diets containing hepatocarcinogens. Experimental and molecular pathology, 1982, Volume: 36, Issue:1 Topics: 2-Acetylaminofluorene; Acute Disease; Animals; Carbon Tetrachloride; Carcinogens; Chemical and Drug Induced Liver Injury; Dactinomycin; Diet; Ethionine; Hydrocortisone; Liver Neoplasms, Experimental; Methyldimethylaminoazobenzene; Polyribosomes; Protein Biosynthesis; Puromycin; Rats; Rats, Inbred Strains; Saline Solution, Hypertonic; Sparsomycin; Thioacetamide; Time Factors	1982
Tunicamycin potently inhibits tumor necrosis factor-induced hepatocyte apoptosis. European journal of pharmacology, 1995, Jan-13, Volume: 292, Issue:2 Topics: Animals; Apoptosis; Cell Line; Cell Survival; Chemical and Drug Induced Liver Injury; Chromatin; Dactinomycin; DNA; Liver; Male; Mice; Mice, Inbred BALB C; Recombinant Proteins; Tumor Necrosis Factor-alpha; Tunicamycin	1995
Comparison of chemotherapies with methotrexate, VP-16 and actinomycin-D in low-risk gestational trophoblastic disease. Remission rates and drug toxicities. Gynecologic and obstetric investigation, 1998, Volume: 46, Issue:1 Topics: Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Chemical and Drug Induced Liver Injury; Chorionic Gonadotropin; Dactinomycin; Drug Administration Schedule; Etoposide; Female; Hematologic Diseases; Humans; Methotrexate; Pregnancy; Remission Induction; Risk Factors; Trophoblastic Neoplasms; Uterine Neoplasms	1998
Tumor necrosis factor-induced lethal hepatitis: pharmacological intervention with verapamil, tannic acid, picotamide and K76COOH. FEBS letters, 2000, Feb-11, Volume: 467, Issue:2-3 Topics: Alanine Transaminase; Animals; Apoptosis; Astringents; Chemical and Drug Induced Liver Injury; Complement Inactivator Proteins; Dactinomycin; Disease Models, Animal; Galactosamine; Hydrolyzable Tannins; Liver; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Phthalic Acids; Platelet Aggregation Inhibitors; Sesquiterpenes; Tumor Necrosis Factor-alpha; Verapamil	2000
Hepatotoxicity of chemotherapy following nephrectomy and radiation therapy for right-sided Wilms tumor. The Journal of pediatrics, 1975, Volume: 87, Issue:4 Topics: Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Child, Preschool; Dactinomycin; Female; Hepatomegaly; Humans; Kidney Neoplasms; Nephrectomy; Thrombocytopenia; Vincristine; Wilms Tumor	1975
Hepatotoxicity of chemotherapy following nephrectomy and radiation therapy for right-sided Wilms tumor. The Journal of pediatrics, 1976, Volume: 88, Issue:5 Topics: Chemical and Drug Induced Liver Injury; Child, Preschool; Dactinomycin; Female; Humans; Liver; Nephrectomy; Vincristine; Wilms Tumor	1976
[Comparison of the nuclear alterations induced by actinomysin D and alpha-amantine in hapatocytes of the rat (author's transl)]. Virchows Archiv. B, Cell pathology, 1977, Feb-08, Volume: 23, Issue:2 Topics: Amanitins; Animals; Cell Nucleolus; Cell Nucleus; Chemical and Drug Induced Liver Injury; Chromatin; Dactinomycin; Liver; Male; Microscopy, Electron; Nucleoproteins; Rats; RNA; Time Factors	1977
[Actinomycin D: toxic effects with special reference to hepatic injury]. Bilten za hematologiju i transfuziju, 1979, Volume: 7, Issue:1 Topics: Adolescent; Chemical and Drug Induced Liver Injury; Dactinomycin; Female; Humans; Infant; Liver Diseases; Male	1979
Induction of rat kidney gluconeogenesis during acute liver intoxication by carbon tetrachloride. The Biochemical journal, 1978, Aug-15, Volume: 174, Issue:2 Topics: Acute Disease; Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Cycloheximide; Dactinomycin; Enzyme Activation; Female; Gluconeogenesis; In Vitro Techniques; Kidney; Liver; Liver Diseases; Phosphoenolpyruvate Carboxykinase (GTP); Rats	1978
Effect of cycloheximide and actinomycin D on carbon tetrachloride hepatotoxicity. Toxicology and applied pharmacology, 1977, Volume: 42, Issue:1 Topics: Animals; Aspartate Aminotransferases; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Cycloheximide; Cytochrome P-450 Enzyme System; Dactinomycin; Lipid Metabolism; Liver; Male; Microsomes, Liver; Proteins; Rats; Time Factors; Triglycerides	1977
VAB-6 chemotherapy causes spurious elevation of alpha-fetoprotein associated with liver dysfunctions. Urologia internationalis, 1991, Volume: 46, Issue:1 Topics: Adult; Alanine Transaminase; alpha-Fetoproteins; Antineoplastic Combined Chemotherapy Protocols; Aspartate Aminotransferases; Biomarkers, Tumor; Bleomycin; Chemical and Drug Induced Liver Injury; Cisplatin; Cyclophosphamide; Dactinomycin; Humans; L-Lactate Dehydrogenase; Liver Diseases; Male; Testicular Neoplasms; Vinblastine	1991
Hepatopathy-thrombocytopenia syndrome--a complication of dactinomycin therapy for Wilms' tumor: a report from the United Kingdom Childrens Cancer Study Group. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1991, Volume: 9, Issue:2 Topics: Antineoplastic Combined Chemotherapy Protocols; Chemical and Drug Induced Liver Injury; Child, Preschool; Dactinomycin; Humans; Infant; Neoplasm Staging; Syndrome; Thrombocytopenia; Vincristine; Wilms Tumor	1991
Hepatotoxicity and actinomycin D. Lancet (London, England), 1990, May-26, Volume: 335, Issue:8700 Topics: Chemical and Drug Induced Liver Injury; Child; Dactinomycin; Drug Administration Schedule; Drug Evaluation; Humans; Wilms Tumor	1990
Severe chemotherapy-related hepatic toxicity associated with MZ protease inhibitor phenotype. The American journal of pediatric hematology/oncology, 1990,Fall, Volume: 12, Issue:3 Topics: Alleles; alpha 1-Antitrypsin; alpha 1-Antitrypsin Deficiency; Antineoplastic Combined Chemotherapy Protocols; Chemical and Drug Induced Liver Injury; Dactinomycin; Disease Susceptibility; Hemorrhage; Heterozygote; Humans; Infant; Kidney Neoplasms; Liver Diseases; Liver Transplantation; Male; Necrosis; Phenotype; Vincristine; Wilms Tumor	1990
[Veno-occlusive disease of the liver and nephroblastoma in children (role of the vincristine-actinomycin combination?]. Annales de pediatrie, 1988, Volume: 35, Issue:7 Topics: Antineoplastic Combined Chemotherapy Protocols; Chemical and Drug Induced Liver Injury; Child, Preschool; Dactinomycin; Humans; Kidney Neoplasms; Liver; Liver Diseases; Male; Vincristine; Wilms Tumor	1988
Hepatotoxicity of actinomycin-D. Lancet (London, England), 1989, Jan-21, Volume: 1, Issue:8630 Topics: Chemical and Drug Induced Liver Injury; Child; Dactinomycin; Drug Administration Schedule; Humans; Prognosis; Wilms Tumor	1989
Accidental actinomycin D overdosage in man, a case report. Cancer chemotherapy and pharmacology, 1988, Volume: 21, Issue:2 Topics: Adolescent; Chemical and Drug Induced Liver Injury; Dactinomycin; Diarrhea; Edema; Electrolytes; Erythema; Humans; Immune Tolerance; Magnesium; Male; Mouth Mucosa; Seizures; Stomatitis	1988
[Cytostatic therapy of lymphogranulomatosis]. Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete, 1972, Dec-01, Volume: 27, Issue:23 Topics: Antineoplastic Agents; Chemical and Drug Induced Liver Injury; Chlorambucil; Cyclophosphamide; Cystitis; Dactinomycin; Hodgkin Disease; Humans; Infections; Nitrogen Mustard Compounds; Procarbazine; Remission, Spontaneous; Time Factors; Triaziquone; Triethylenemelamine; Vinblastine	1972
Inhibition of the actinomycin-induced nucleolar change by thioacetamide in mouse hepatic parenchymal cell. Laboratory investigation; a journal of technical methods and pathology, 1967, Volume: 17, Issue:6 Topics: Amides; Animals; Cell Nucleolus; Chemical and Drug Induced Liver Injury; Dactinomycin; Liver; Liver Diseases; Mice; Staining and Labeling; Sulfhydryl Compounds	1967
Different susceptibilities of chick embryo liver cells in vitro to aflatoxin, actinomycin D, and mitomycin C. Zeitschrift fur Krebsforschung, 1968, Volume: 71, Issue:3 Topics: Aflatoxins; Animals; Anti-Bacterial Agents; Autoradiography; Cell Nucleolus; Chemical and Drug Induced Liver Injury; Chick Embryo; Cytoplasm; Dactinomycin; DNA; Liver; RNA	1968
The treatment of severe myasthenia gravis with immunosuppressive agents. European neurology, 1969, Volume: 2, Issue:6 Topics: Adolescent; Adult; Age Factors; Agranulocytosis; Aminopterin; Azathioprine; Chemical and Drug Induced Liver Injury; Cholinesterase Inhibitors; Dactinomycin; Drug Synergism; Female; Humans; Immunosuppressive Agents; Male; Mercaptopurine; Methotrexate; Middle Aged; Myasthenia Gravis; Time Factors	1969
Activity of nicotinamide-adenine dinucleotide pyrophosphorylase in liver nuclei. Effects of partial hepatectomy, hepatotoxins and dietary changes. The Biochemical journal, 1968, Volume: 108, Issue:1 Topics: Animals; Animals, Newborn; Cell Nucleus; Chemical and Drug Induced Liver Injury; Dactinomycin; Dietary Proteins; Glycosides; Hepatectomy; Hepatitis A; Liver; Liver Regeneration; Male; Mice; Murine hepatitis virus; Mycotoxins; Nucleotidyltransferases; Protein Deficiency; Rats; Starvation; Stimulation, Chemical	1968
Effect of mercuric chloride on plasma renin substrate level in rats. The American journal of physiology, 1972, Volume: 222, Issue:1 Topics: Angiotensin II; Animals; Blood Volume; Chemical and Drug Induced Liver Injury; Chlorides; Dactinomycin; Electrophoresis; Female; Kidney; Liver; Mercury Poisoning; Puromycin; Rats; Renin; Swine	1972
Inhibition by aflatonin B-1 of hydrocortisone induction of rat liver tryptophan pyrrolase and tyrosine transaminase. Archives of biochemistry and biophysics, 1968, Volume: 128, Issue:2 Topics: Aflatoxins; Animals; Chemical and Drug Induced Liver Injury; Dactinomycin; Depression, Chemical; Enzyme Induction; Hydrocortisone; Liver; Male; Puromycin; Rats; Stimulation, Chemical; Time Factors; Tryptophan Oxygenase; Tyrosine Transaminase	1968
Evidence for a reduced active life-span of messenger RNA in liver of rats poisoned with carbon tetrachloride. Experimental and molecular pathology, 1973, Volume: 19, Issue:1 Topics: Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Cycloheximide; Dactinomycin; Liver; Male; Orotic Acid; Polyribosomes; Rats; RNA, Messenger; RNA, Ribosomal; Tritium	1973
Effects of inhibitors of protein and ribonucleic acid synthesis on naphthyliso-thiocyanate-induced hyperbilirubinemia, sulfobromophthalein retention and prolongation of pentobarbital hypnosis. The Journal of pharmacology and experimental therapeutics, 1974, Volume: 189, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cycloheximide; Dactinomycin; Depression, Chemical; Dose-Response Relationship, Drug; Drug Synergism; Ethionine; Female; Hyperbilirubinemia; Male; Pentobarbital; Protein Biosynthesis; Rats; RNA; Sex Factors; Sleep; Sulfobromophthalein; Thiocyanates; Time Factors	1974
[Morphological study of actinomycin D (dactinomycin)]. Antibiotiki, 1970, Volume: 15, Issue:12 Topics: Animals; Body Weight; Bone Marrow; Bone Marrow Cells; Chemical and Drug Induced Liver Injury; Dactinomycin; Depression, Chemical; Enzymes; Hematopoiesis; Histocytochemistry; Injections, Intraperitoneal; Injections, Subcutaneous; Liver; Lung; Mice; Pulmonary Fibrosis; Rabbits; RNA; Spleen; Splenic Diseases; Thrombosis; Time Factors	1970