dacarbazine has been researched along with Brain Neoplasms in 2287 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 28 (1.22) | 18.7374 |
| 1990's | 43 (1.88) | 18.2507 |
| 2000's | 619 (27.07) | 29.6817 |
| 2010's | 1512 (66.11) | 24.3611 |
| 2020's | 85 (3.72) | 2.80 |
| Authors | Studies |
|---|---|
| Benvenuto, J; Farquhar, D | 1 |
| Fuchs, D; Morandi, L; Nytko, KJ; Rohrer Bley, C; Tonon, C; Tresch, NS | 1 |
| Huang, B; Liang, R; Yu, Z | 1 |
| Bender, S; Brada, M; Cseh, A; Gattamaneni, R; Harris, F; James, A; Jefferies, S; McBain, C; Pemberton, K; Saran, F; Schaible, J; Welsh, L | 1 |
| Ameratunga, M; McLean, C; Zaman, FY | 1 |
| Sun, X; Xu, X; Xu, Y; Zhan, W; Zhao, L; Zhu, Y | 1 |
| Bitar, M; Makalowski, J; Schirrmacher, V; Stuecker, W; Van de Vliet, P; Van Gool, SW | 1 |
| Germano, IM; Olson, JJ; Ormond, DR; Wen, P; Ziu, M | 1 |
| Aldape, K; Atmodimedjo, PN; Baumert, BG; Baurain, JF; Brandes, AA; Brouwer, RWW; Cheung, KJ; Chinot, OL; Clement, PM; de Heer, I; Dubbink, HJ; Erridge, SC; French, PJ; Gill, S; Golfinopoulos, V; Gorlia, T; Griffin, M; Hoogstrate, Y; Jenkins, RB; Kros, JM; Mason, WP; McBain, C; Nowak, AK; Rogers, L; Rudà, R; Sanson, M; Taal, W; Tesileanu, CMS; van den Bent, MJ; van IJcken, WFJ; van Linde, ME; Vogelbaum, MA; von Deimling, A; Weller, M; Wesseling, P; Wheeler, H; Wick, W | 1 |
| Arunsingh, MA; Basu Achari, R; Bhattacharyya, T; Biswas, B; Chakraborty, S; Chandra, A; Chatterjee, S; Das, A; Goyal, L; Mallick, I; Mishra, D; Parihar, M; Roy, P; Saha, S; Zameer, L | 1 |
| Chamallamudi, MR; Kumar, G; Kumar, N; Nandakumar, K; Rao, V; Thorat, ND; Vibhavari, RJA | 1 |
| In Yoon, H; Lee, SW; Lim, DH; Wee, CW | 1 |
| Iorgulescu, JB; Kavouridis, VK; Ligon, KL; Wen, PY | 1 |
| Amatu, A; Barault, L; Bardelli, A; Bartolini, A; Battuello, P; Bonoldi, E; Cassingena, A; Crisafulli, G; Di Nicolantonio, F; Germano, G; Idotta, L; Lazzari, L; Luraghi, P; Macagno, M; Marsoni, S; Mauri, G; Morano, F; Personeni, N; Pessei, V; Pietrantonio, F; Sartore-Bianchi, A; Siena, S; Tosi, F; Valtorta, E; Vitiello, PP; Zampino, MG | 1 |
| Baro, V; Busato, F; Causin, F; Cerretti, G; Chioffi, F; d'Avella, D; Della Puppa, A; Denaro, L; Fiduccia, P; Landi, A; Lombardi, G; Todoverto, M; Volpin, F; Zagonel, V | 1 |
| Altinoz, MA; Elmaci, İ; Er, O; Gokhan Ekmekci, C; Hacker, E; Kahraman Ozlu, EB; Ozpinar, A; Sari, R; Turkgenc, B | 1 |
| Banchi, M; Bocci, G; Cucchiara, F; Danesi, R; Di Paolo, A; Giannini, N; Giorgi, FS; Luci, G; Orlandi, P; Pasqualetti, F | 1 |
| Li, H; Ma, W; Qu, T; Wang, Y; Wu, J; Xia, Y; Xing, H; Zhao, B | 1 |
| Internò, V; Porta, C; Rudà, R; Sergi, MC; Soffietti, R | 1 |
| Celis-López, MÁ; Cid-Sánchez, DR; Contreras-Palafox, GA; Flores-Vázquez, JG; Gutiérrez-Aceves, GA; Heredia-Gutiérrez, JC; Hernández-Sánchez, LC; Macías-González, MDS; Moreno-Jiménez, S; Moscardini-Martelli, J; Olmos-Guzmán, A; Ortiz-Arce, CS; Pérez, SR; Rodríguez-Camacho, A; Suárez-Campos, JJE; Torres-Ríos, JA | 1 |
| Miyakita, Y; Narita, Y; Ohno, M; Takahashi, M; Tamura, Y; Yanagisawa, S | 1 |
| Bindra, RS; Gueble, SE; Herzon, SB; Huseman, ED; Lin, K; Sundaram, RK | 1 |
| Alaverdian, DA; Buntovskaya, AS; Chernov, AN; Fedorov, EV; Filatenkova, TA; Galimova, ES; Glushakov, RI; Kim, AV; Matsko, MV; Shamova, OV; Skliar, SS; Tsapieva, AN | 1 |
| Ligon, KL; Lim-Fat, MJ; Nassar, AH; Rahman, R; Shi, DD; Wen, PY; Youssef, GC | 1 |
| Garzio, K; Grossman, S; Holdhoff, M; McElroy, K; Ozer, B; Yankulina, O | 1 |
| Gan, T; Miao, F; Nie, E; Qian, X; Shen, Z; Shi, Q; Wang, P; Wang, Q; Wang, Y; Xie, M; Zhao, S | 1 |
| Becker, H; Blobner, J; Egensperger, R; Katzendobler, S; Niyazi, M; Quach, S; Suchorska, B; Thiele, F; Thon, N; Tonn, JC; Weller, J; Weller, M | 1 |
| Gao, J; Kang, ZF; Mai, A; Ting, WJ; Tu, JY; Yao, QM; Ye, SW | 1 |
| Gong, X; Liu, C; She, L; Su, L | 1 |
| Carpentier, A; Chinot, O; Cornu, P; Delattre, JY; Dufour, H; Emery, E; Faillot, T; Guillamo, JS; Guyotat, J; Hajage, D; Honnorat, J; Laigle-Donadey, F; Lebbah, S; Menei, P; Metellus, P; Paquis, P; Peruzzi, P; Proust, F; Wager, M | 1 |
| Ai, P; Chen, J; He, L; Huang, Y; Li, R; Liu, Z; Pei, Y; Peng, X; Wang, J; Wei, Z; Zhao, F | 1 |
| Baek, JY; Beom, SH; Cha, Y; Choi, J; Choi, MK; Hong, YS; Kim, J; Kim, JE; Kim, JH; Kim, SY; Kim, TW; Lee, JS; Lim, SB; Oh, CR; Park, IJ; Park, JH | 1 |
| Chung, S; Huang, J; Sugimoto, Y; Zhang, M | 1 |
| Chen, ZS; Claret, FX; Elkabets, M; Kong, D; Liang, H; Lin, HW; Peng, X; Sun, F; Wang, F; Wang, R; Wang, Y; Yu, Z; Zhang, L; Zhang, S; Zhong, Z; Zhou, Z | 1 |
| Amoroso, B; Aronchik, I; Chang, H; Filvaroff, E; González León, P; Hanna, B; Manuel Sepúlveda, J; Mendez, C; Moreno, V; Nikolova, Z; Pérez-Núñez, Á; Reardon, DA; Sanchez-Perez, T; Stephens, D; Vogelbaum, MA; Zuraek, M | 1 |
| Li, L; Liu, H; Ma, H; Qian, F; Quan, A; Ren, Y; Wang, L; Xu, H; Yu, R; Zhang, Y | 1 |
| Brehmer, S; Bullinger, L; Giordano, FA; Glas, M; Goldbrunner, R; Grauer, O; Hau, P; Herrlinger, U; Kowalski, T; Krex, D; Potthoff, AL; Ringel, F; Sabel, M; Schäfer, N; Schaub, C; Schmidt-Graf, F; Schneider, M; Schnell, O; Seidel, C; Steinbach, JP; Tabatabai, G; Tonn, JC; Tzaridis, T; Vajkoczy, P; Vatter, H; Weller, J; Zeiner, PS; Zeyen, T | 1 |
| Cai, L; Cao, X; Chen, Y; Chen, Z; Deng, M; Du, X; Guo, C; Hu, W; Hu, X; Jiang, T; Jiang, X; Ke, C; Li, C; Li, D; Li, G; Li, J; Li, X; Li, Z; Lin, F; Liu, J; Liu, M; Lv, X; Lv, Y; Mou, Y; Ni, X; Ouyang, H; Qin, Z; Sai, K; Su, J; Wang, H; Wang, J; Wang, Y; Wu, S; Xi, S; Xu, P; Xue, X; Yang, H; Yang, Q; Zeng, J; Zhang, J; Zhang, X; Zhong, S; Zhou, T | 1 |
| Elsaid, AA; Elsaka, R; Kitagwa, JM; Mahmoud, AA; Meheissen, MAM; Refaat, T; Shaikh, H | 1 |
| Aldegheri, V; Bosio, A; Caccese, M; Cerretti, G; Chioffi, F; Della Puppa, A; Denaro, L; Guarneri, V; Lombardi, G; Padovan, M; Zagonel, V | 1 |
| Huang, Q; Yang, L; Ye, Z | 1 |
| Birkl-Toeglhofer, AM; Brawanski, KR; Freyschlag, CF; Haybaeck, J; Hoeftberger, R; Manzl, C; Sprung, S; Ströbel, T; Thomé, C | 1 |
| Azambuja, JH; Braganhol, E; de Cássia Sant'ana, R; de Souza, PO; Debom, GN; Fachel, FNS; Gelsleichter, NE; Lenz, GS; Michels, LR; Roliano, GG; Teixeira, FC; Teixeira, HF; Visioli, F | 1 |
| Alalami, H; Bannykh, S; Fan, X; Hu, J | 1 |
| Chen, CC; Li, M; Ma, J; Wang, Z | 1 |
| Bonsanto, MM; Leppert, J; Rades, D; Trillenberg, P; Yu, NY; Zemskova, O | 1 |
| Bradshaw, TD; Lewis, W; Moody, CJ; Stevens, MFG; Summers, HS; Williams, HEL | 1 |
| Harter, PN; Herms, J; Katzendobler, S; Niedermeyer, S; Niyazi, M; Stoecklein, VM; Thon, N; Tonn, JC; Trumm, C; Weller, J | 1 |
| Chen, F; Deng, J; Jiang, J; Kang, X; Kang, Z; Li, S; Li, W; Yang, H; Zhang, J | 1 |
| Badalamenti, G; Barretta, ML; Buonaiuto, M; Cannella, L; Chiariotti, L; Clemente, O; De Chiara, AR; Della Monica, R; Di Marzo, M; Di Mauro, A; Guida, M; Iervolino, D; Marretta, AL; Tafuto, S; Vincenzi, B | 1 |
| Barberis, A; Bocci, G; Buffa, FM; Caffo, M; De Salvo, GL; Harris, AL; Ius, T; Lombardi, G; Mazzanti, CM; Montemurro, N; Paiar, F; Pasqualetti, F; Soffietti, R; Zanotti, S | 1 |
| Castresana, JS; Denizler-Ebiri, FN; Güven, M; Taşpınar, F; Taşpınar, M | 1 |
| Ali, A; Alnahhas, I; Cappelli, L; Kayne, A; Khan, MM; Miller, R; Niazi, M; Poiset, S; Shi, W | 1 |
| Ji, N; Wang, J; Wang, N; Wang, P; Yue, S | 1 |
| Grzywna, E; Krajcer, A; Lewandowska-Łańcucka, J | 1 |
| Bu, L; Cai, J; Chen, Q; Huang, K; Meng, X; Weng, Y; Xu, Q; Zhan, R; Zhang, L; Zheng, X | 1 |
| Fionda, C; Fontanella, RA; Gaetano, C; Illi, B; Malatesta, S; Salvatori, L; Somma, MP; Stabile, H | 1 |
| Arijs, I; Balvers, RK; Beerepoot, LV; Biswas, A; Byrne, AT; Chi Yen, RT; Connor, K; Dilcan, G; Dirven, CMF; Fabro, F; Idbaih, A; Jimenez-Cowell, K; Ju, J; Kers, TV; Kleijn, A; Klein, M; Kremer, A; Kros, JM; Lambrechts, D; Lamfers, MLM; Lawler, SE; Leenstra, S; Li, Y; Lodi, F; Ntafoulis, I; O'Farrell, AC; Prehn, JHM; Salvucci, M; Stubbs, AP; van den Bent, MJ; Verreault, M | 1 |
| Antonelli, M; Arcella, A; Bozzao, A; Capone, L; De Pietro, R; Esposito, V; Gianno, F; Giraffa, M; Lanzetta, G; Minniti, G; Paolini, S; Romano, A; Tini, P | 1 |
| Duffy, C; Galldiks, N; Glas, M; Goldbrunner, R; Grauer, O; Hattingen, E; Hau, P; Herrlinger, U; Krex, D; Nitsch, L; Paech, D; Potthoff, AL; Radbruch, A; Schäfer, N; Schaub, C; Schlegel, U; Schneider, M; Seidel, C; Steinbach, JP; Stummer, W; Tabatabai, G; Tzaridis, T; Weller, J; Zeiner, PS; Zeyen, T | 1 |
| Chen, Y; Qi, H; Qu, W; Tu, J | 1 |
| Berglund, AE; Etame, AB; Macaulay, RJ; Wu, Q | 1 |
| Alcaniz, J; Benesch, M; Birkl-Toeglhofer, AM; Golob-Schwarzl, N; Haybaeck, J; Hoffmann, J; Huber, HJ; Krassnig, S; Leber, SL; Leoni, M; Mahdy-Ali, K; Naumann, M; Orthmann, A; Pennauer, M; Raicht, A; Skofler, C; von Campe, G; Wälchli, T; Weis, S; Wohlrab, C | 1 |
| Arijs, I; Beerens, C; Biswas, A; Byrne, AT; Chien, MP; Connor, K; Dilcan, G; Fabro, F; Feller, KJ; Idbaih, A; Kers, TV; Kremer, A; Lambrechts, D; Lamfers, MLM; Leenstra, S; Lodi, F; Ntafoulis, I; O'Farrell, AC; Prehn, JHM; Salvucci, M; Tching Chi Yen, R; Verreault, M | 1 |
| Ayala-Hernández, LE; Bosque, JJ; Chulián, S; Delobel, T; García-Ferrer, M; Murek, M; Pérez-Beteta, J; Pérez-García, VM; Piñero, P; Schucht, P | 1 |
| Frandsen, S; Geissler, UW; Gredal, O; Møller, S; Nørøxe, DS; Pedersen, AJ | 1 |
| Bian, L; Li, D; Li, K; Lin, B; Liu, X; Xi, Z; Yan, J; Yang, Q | 1 |
| Handelman, SK; Jain, HV; Sorribes, IC | 1 |
| Li, D; Ma, JP; Wang, L; Weng, JC; Wu, Z; Zhang, JT; Zhang, Y | 1 |
| Haggiagi, A; Lassman, AB | 1 |
| Alam, A; Mohile, N; Wasilewski, A | 1 |
| Chen, TC; Cho, HY; Duc, TC; Hartman, H; Hofman, FM; Huang, M; Minea, RO; Schönthal, AH; Swenson, SD | 1 |
| Liu, Y; Milano, MT; Mohile, NA; Richardson, M; Serventi, JN; Strawderman, MS; Walter, KA; Warren, KT | 1 |
| Aldape, K; Armstrong, TS; Gerstner, ER; Gilbert, MR; Lieberman, F; Mendoza, T; Mikkelsen, T; Omuro, A; Robins, HI; Vera, E; Wen, PY; Wu, J; Yuan, Y | 1 |
| Chambers, C; Coppens, R; de Robles, P; Dersch-Mills, D; Folkman, F; Ghosh, S; Hsu, PYH; Leckie, C | 1 |
| Akimoto, J; Narita, Y; Tanaka, S | 1 |
| Bardhi, R; Daveluy, S; Farshchian, M | 1 |
| Cloughesy, TF; Lassman, AB | 1 |
| Anghileri, E; Fabi, A; Gaviani, P; Lanzetta, G; Lombardi, G; Pace, A; Pronello, E; Prosperini, L; Rizzato, S; Rudà, R; Scaringi, C; Simonetti, G; Targato, G; Villani, V | 1 |
| Alghamdi, B; Alkhayyat, S; Baeesa, S; Bardeesi, A; Bari, MO; Butt, NS; Dallol, A; Kurdi, M; Lary, AI; Maghrabi, Y; Mohamed, F; Saeedi, R; Samkari, A | 1 |
| Dong, L; Jiang, X; Meng, L; Qu, C; Wang, B; Wang, H; Wei, J; Xin, Y; Zhao, Q | 1 |
| Aboud, O; Ahmad, S; Antony, R; Armstrong, TS; Boris, L; Bryla, C; Burton, EM; Butler, MK; Calvo, KR; Cordova, C; Figg, WD; Fink, D; Gallin, JI; Garren, N; Gilbert, MR; Gonzales, J; Grajkowska, E; Kuhns, DB; Leeper, H; Lindsley, M; Lollo, N; Long Priel, DA; Mendoza, TR; Mentges, K; Pang, Y; Peer, CJ; Penas-Prado, M; Siegel, C; Sissung, TM; Su, YT; Theeler, BJ; Vera, E; Wu, J; Yu, G; Yuan, Y | 1 |
| Greenspoon, JN; Mir, T; Pond, G | 1 |
| Bastiancich, C; Bozzato, E; Henley, I; Newland, B | 1 |
| Annavarapu, S; Davies, K; Gogate, A; Pham, T; Robert, N; Singh, P | 1 |
| Fioretzaki, R; Kosmas, C; Papageorgiou, G; Tsakatikas, S | 1 |
| Friesen, C; Misch, M; Onken, J; Vajkoczy, P | 1 |
| Efferth, T; Giordano, FA; Krishna, S; Schmiedek, P; Schöttler, U; Wenz, F | 1 |
| Baumert, BG; Brands, E; Dik, R; Fedrigo, CA; Narayan, RS; Peters, GJ; Slotman, BJ; Sminia, P; Stalpers, LJ; Westerman, BA | 1 |
| Han, Y; Huang, BS; Huang, D; Luo, QZ; Tang, QP; Wu, LX | 1 |
| Chang, CW; Chen, HH; Chiang, CS; Chiang, WH; Chiu, HC; Huang, WC; Lin, YW; Lu, IL; Tsai, YC | 1 |
| Khazaei, M; Pazhouhi, M | 1 |
| Cheng, W; Han, S; Jiang, Y; Meng, L; Tie, X; Wu, A; Xia, J | 1 |
| Alattar, AA; Ali, MA; Brandel, MG; Carroll, KT; Carter, B; Chen, CC; Hirshman, B; Lanman, T; Lochte, B | 1 |
| Desai, AS; Desideri, S; Fisher, JD; Grossman, SA; Holdhoff, M; Leal, J; Lesser, GJ; Lieberman, FS; Lodge, MA; Nabors, LB; Read, WL; Schiff, D; Supko, JG; Wahl, RL; Walbert, T; Ye, X | 1 |
| Baumert, BG; Blumenthal, DT; Brown, PD; Burt Nabors, L; Corn, BW; Erridge, SC; Gilbert, MR; Golfinopoulos, V; Gorlia, T; Hegi, ME; Hyun Nam, D; Kim, MM; Mason, WP; Mehta, MP; Mirimanoff, RO; Perry, JR; Reardon, DA; Stupp, R; van den Bent, MJ; Weller, M; Zhang, P | 1 |
| Barnaby, SN; Cayton, TC; Chalastanis, A; Cole, LE; Ghelfi, ST; Hurley, LA; James, CD; Kouri, FM; Lee, A; May, JL; Merkel, TJ; Mirkin, CA; Savalia, N; Sita, TL; Sprangers, AJ; Stegh, AH | 1 |
| Jin, X; Lv, M; Sun, P; Tong, G; Wang, N; Zhu, X | 1 |
| Fang, Y; Luo, L; Ning, B; Wang, N; Zhang, Q | 2 |
| Jiang, T; Schiff, D; Wen, PY | 1 |
| Alexander, B; Ballman, K; Grossman, SA; Schreck, KC | 1 |
| Algara, M; Foro Arnalot, P; Granados, R; Membrive, I; Ortiz, A; Pera, O; Reig, A; Rodriguez, N; Sanz, X | 1 |
| Kesari, S; Ram, Z | 1 |
| Balça-Silva, J; do Carmo, A; Dubois, LG; Echevarria-Lima, J; Ferrer, VP; Lopes, MC; Matias, D; Moura-Neto, V; Pontes, B; Rosário, L; Sarmento-Ribeiro, AB | 1 |
| Combs, SE; Straube, C | 1 |
| Finiuk, N; Grytsyna, II; Klyuchivska, OY; Lehka, L; Lesyk, RB; Panchuk, RR; Starykovych, MO; Stoika, RS; Zіmenkovsky, BS; Коbylinska, LI | 1 |
| Liu, YG; Song, Y; Wang, HW; Xu, ZK | 1 |
| Bian, XW; Chen, X; Huang, N; Li, C; Li, H; Liu, S; Shen, HY; Wang, Y; Wu, N; Xiao, L; Yu, S | 1 |
| Grosch, J; Hänggi, D; Jung, E; Lemke, D; Osswald, M; Ratliff, M; Solecki, G; Weil, S; Wick, W; Winkler, F | 1 |
| Dong, Y; Furuta, T; Hayashi, Y; Kinoshita, M; Minamoto, T; Miyashita, K; Nakada, M; Sabit, H; Uchiyama, N | 1 |
| Cerione, RA; Nakano, I; Rojas, K; Sullivan, KE; Wilson, KF | 1 |
| Jin, X; Liu, N; Nie, E; Shi, Z; Wu, W; You, Y; Yu, T; Zhang, J; Zhou, X | 1 |
| Roth, P; Silginer, M; Stupp, R; Weller, M | 1 |
| Cai, W; He, M; Li, K; Liu, A; Luo, M; Ouyang, L; Pi, R; Tu, Y | 1 |
| Ohara, K; Sasaki, H; Tamura, R; Tokuda, Y; Yoshida, K | 1 |
| Allemanni, G; Banelli, B; Daga, A; Forlani, A; Marubbi, D; Pistillo, MP; Profumo, A; Romani, M | 1 |
| Battelli, C; Blaszyk, H; Chow, KH; Emery, IF; Florman, J; George, J; Gopalan, A; Wood, S; Yun, K | 1 |
| Baernreuther, J; Kamp, MA; Rapp, M; Sabel, M; Steiger, HJ; Turowski, B | 1 |
| Altinoz, MA; Bolukbasi, FH; Ekmekci, CG; Elmaci, I; Sari, R; Sav, A; Yenmis, G | 1 |
| Liu, L; Liu, Y; Wang, P; Xue, Y; Yao, Y; Yu, Q | 1 |
| Du Preez, A; Egeland, M; Fernandes, C; Guinaudie, C; Musaelyan, K; Pariante, CM; Thuret, S; Zunszain, PA | 1 |
| Fan, X; Lan, T; Qu, Y; Song, Y; Wang, H; Yu, C; Zhan, Q; Zhang, M; Zhang, Z; Zhao, Z | 1 |
| Cai, J; Han, B; Jiang, C; Li, J; Li, Z; Lin, L; Meng, X; Ming, J; Sun, B; Wang, R; Wu, P | 1 |
| Griguer, CE; Langford, C; Oliva, CR; Suto, MJ; Zhang, W | 1 |
| Abrey, LE; Brennan, CW; Briggs, S; Cairncross, JG; Chakravarty, D; DeAngelis, LM; Faivre, G; Forsyth, P; Gao, J; Grimm, S; Huse, JT; Jonsson, P; Kaley, T; Louis, DN; Martinez, NL; Matasar, M; Mehta, J; Mohile, NA; Moskowitz, C; Nimer, SD; Omuro, A; Paleologos, N; Panageas, KS; Raizer, J; Sauter, CS; Schultz, N; Terziev, R; Thomas, AA | 1 |
| Alter, RA; Boockvar, JA; Chakraborty, S; Fanous, AA; Filippi, CG; Pisapia, DJ; Tsiouris, AJ; White, TG | 1 |
| Aghi, MK; Berger, MS; Choi, S; Chou, A; Flanigan, PM; Jahangiri, A; Kuang, R; McDermott, MW; Molinaro, AM; Truong, A | 1 |
| Liang, DS; Liu, YJ; Ma, YC; Qi, XR; Wu, ZF; Yang, ZZ; Zhang, WJ | 1 |
| Trogrlić, D; Trogrlić, I; Trogrlić, Z | 1 |
| Abdollahi, A; Dokic, I; Klein, C; Oancea-Castillo, LR; Régnier-Vigouroux, A; Weber, KJ | 1 |
| Bielecka-Wajdman, AM; Lesiak, M; Ludyga, T; Obuchowicz, E; Sieroń, A | 1 |
| Chen, Y; Li, R; Liu, N; Pan, M; Shi, Z; Wang, X; Yan, W; You, Y; Zhang, J | 1 |
| Glumac, M; Jakimov, D; Kojic, V; Pejin, B; Tommonaro, G | 1 |
| Chandler, J; Fountas, L; Grimm, S; Helenowski, I; Kumthekar, P; Levy, R; Marymont, M; McCarthy, K; Mehta, M; Muro, K; Raizer, J | 1 |
| Chen, T; Fu, A; Li, J; Li, M; Song, X; Zhu, J | 1 |
| Asai, A; Ito, T; Iwata, R; Kanemura, Y; Koike, T; Maruyama, M; Nakano, Y; Nomura, S; Nonaka, M; Oe, S; Sugimoto, T; Yamada, H; Yoshimura, K | 1 |
| Dai, J; Ma, K; Niu, L; Pan, Y; Wang, X; Yin, H; Yuan, G; Zhang, Y; Zhou, W | 1 |
| Cappabianca, P; Cavallo, LM; Frio, F; Grujicic, D; Illic, R; Lavrnic, S; Milicevic, M; Milosevic, S; Nikitovic, M; Raicevic, S; Savic, D; Solari, D; Somma, T | 1 |
| An, M; Beattie, CE; Jaros, BD; Welker, AM | 1 |
| Dal-Cim, TA; Lopes, FG; Nedel, CB; Oliveira, KA; Tasca, CI | 1 |
| Choi, SH; Kim, E; Kim, IH; Kim, JW; Kim, TM; Lee, ST; Park, CK; Wee, CW; Yoo, RE | 1 |
| Nabors, LB | 1 |
| Rushworth, SA; Steverding, D | 1 |
| Li, J; Long, C; Peng, P; Wei, W | 1 |
| Koshy, M; Rusthoven, CG; Sher, DJ | 1 |
| Laperriere, N; Mason, WP; Perry, JR | 1 |
| Jahan, N; Lee, JM; Shah, K; Wakimoto, H | 1 |
| Herrera-Rios, D; Hoerbelt, T; Jiang, T; Kahlert, UD; Koch, K; Li, G; Maciaczyk, D; Maciaczyk, J; Marquardt, V; Ouwens, DM; Pauck, D; Picard, D; Remke, M; Steiger, HJ; Zhang, W; Zhao, L | 1 |
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| Anderson, MD; Gilbert, MR | 1 |
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| Caroli, M; Condomitti, G; Di Vito, C; Galli, R; Giussani, P; Riboni, L; Riccitelli, E; Tringali, C; Viani, P | 1 |
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| Broholm, H; Christensen, IJ; Grunnet, K; Kosteljanetz, M; Michaelsen, SR; Poulsen, HS; Stockhausen, MT | 1 |
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| Defrates, SR; Lightner, DD; Mannas, JP; Pittman, T; Villano, JL | 1 |
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| Armstrong, TS; Bottomley, A; Brachman, DG; Choucair, AK; Coens, C; Gilbert, MR; Mehta, M; Mendoza, TR; Wang, M; Wefel, JS; Werner-Wasik, M; Won, M | 1 |
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| Al-Nuaimi, SK; Alnaami, IM; Gourishankar, S; Mehta, V; Murtha, AD; Senthilselvan, A; Walling, S | 1 |
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| Cao, H; Chen, L; Fan, CH; Jiang, G; Liu, WL; Wen, C | 1 |
| Allgeier, A; Bottomley, A; de Gans, J; Delgadillo, D; Enting, RH; Gijtenbeek, AM; Habets, EJ; Hoang-Xuan, K; Klein, M; Nederend, S; Reijneveld, JC; Seute, T; Taphoorn, MJ; Tijssen, CC; van den Bent, MJ | 1 |
| Cai, S; Cheng, JX; Dong, Y; Liu, BL; Yin, AA; Zhang, LH; Zhang, X | 1 |
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| Chang, S; Costello, JF; Fouse, SD; James, CD; Nakamura, JL | 1 |
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| Boothman, DA; Burma, S; Chakraborty, S; Habib, AA; Hatanpaa, KJ; Koduru, P; Li, L; Puliyappadamba, VT; Rehman, A; Saha, D; Souza, RF; Vemireddy, V | 1 |
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| Chang, JH; Chung, YG; Kang, SH; Kim, CH; Kim, JH; Kim, JM; Koh, YC; Kong, DS; Lee, JW; Lim, YJ; Nam, DH | 1 |
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| Hatakeyama, S; Ikeda, T; Morisawa, Y; Norizuki, M; Okabe, T; Onishi, T; Sasahara, T; Suzuki, J; Toshima, M; Yokota, H | 1 |
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| Armstrong, TS; Batchelor, TT; Chang, SM; Cloughesy, T; Galanis, E; Gilbert, M; Gondi, V; Ismaila, N; Lovely, M; Mehta, M; Mumber, MP; Sloan, A; Sulman, EP; Tsien, C | 1 |
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| Christensen, BC; Davis, MC; Ernstoff, MS; Fadul, CE; Fisher, JL; Gaur, AB; Hampton, TH; Lewis, LD; Rahme, GJ; Steel, SE; Thomas, AA; Tsongalis, GJ; Whipple, CA | 1 |
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| Aldape, KD; Batchelor, TT; Chang, SM; Chen, A; Cloughesy, TF; de Groot, J; DeAngelis, LM; Drappatz, J; Fisher, J; Gilbert, MR; Grossman, S; Lieberman, F; Nayak, L; Omuro, A; Prados, M; Wefel, JS; Wen, PY; Ye, X; Yung, AW | 1 |
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| Chang, JH; Choe, G; Choi, SH; Kim, CY; Kim, E; Kim, IA; Kim, IH; Kim, JH; Kim, JW; Kim, N; Kim, SH; Kim, TM; Kim, YJ; Lee, ST; Park, CK; Park, SH; Suh, CO; Wee, CW | 1 |
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| Bräuer-Krisch, E; Bravin, A; Keyriläinen, J; Le Duc, G; Régnard, P; Troprès, I | 1 |
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| Ali-Osman, F; Bigner, DD; Friedman, AH; Friedman, HS; Horne, KS; Johnson, SP; Lister, DW; Maxwell, JA; McLendon, RE; Modrich, PL; Quinn, JA; Rasheed, A | 1 |
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| Fichtner, I; Hess-Stumpp, H; Hoffmann, J; Hofmann, B; Klar, U; Lemm, M; Lienau, P; Rotgeri, A | 1 |
| Brandes, AA; Dietrich, PY; Hottinger, AF; Stupp, R; van den Bent, MJ | 1 |
| Baumert, BG; Stupp, R | 2 |
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| Adamson, PC; Blaney, SM; Dancey, JE; Gilbertson, RJ; Hamilton, M; Ingle, AM; Jakacki, RI; Krailo, MD; Tersak, J; Voss, SD | 1 |
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| Ang, KK; Chakravarti, A; Chinnaiyan, P; Curran, W; Hammond, E; Mehta, MP; Rojiani, AM; Tofilon, PJ; Wang, M; Zhang, HZ | 1 |
| Cao, Y; Gomez-Hassan, D; Hayman, J; Junck, L; Lawrence, TS; Lee, IH; Piert, M; Rogers, L; Ten Haken, RK; Tsien, C | 1 |
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| Attenello, FJ; Brem, H; Chaichana, KL; Gathinji, M; McGirt, MJ; Olivi, A; Quiñones-Hinojosa, AR; Than, K; Weingart, JD | 1 |
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| Anderson, J; Avedissian, R; Croteau, D; Doyle, T; Gutierrez, J; Hasselbach, L; Margolis, J; Mikkelsen, T; Paleologos, N; Schultz, L | 1 |
| Ehrenreich, H; Giese, A; Hasselblatt, M; Hassouna, I; Jelkmann, W; Kim, E; Rave-Fränk, M; Schulz-Schaeffer, W; Sperling, S | 1 |
| Becker, G; Borberg, SK; Fischedick, AR; Frommolt, P; Grauthoff, H; Herfarth, K; Kocher, M; Müller, RP; Niewald, M; Rühl, U; Staar, S; Steingräber, M; Stuschke, M | 1 |
| Khaitan, D; Meister, EA; Ningaraj, NS; Sankpal, UT; Vats, T | 1 |
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| Goldhoff, P; Hope, A; Jackson, E; Limbrick, DD; Perry, A; Piwnica-Worms, D; Rubin, JB; Warrington, NM; Woerner, BM | 1 |
| De Nève, N; Dehoux, M; Dewelle, J; Gaussin, JF; Kiss, R; Le Mercier, M; Lefranc, F; Mathieu, V | 1 |
| Chang, HW; Chang, WN; Ho, JT; Lin, WC; Lin, YJ; Lu, CH; Wang, HC; Yang, TM | 1 |
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| Berger, MS; Dinca, EB; Haas-Kogan, DA; James, CD; Lu, KV; Pieper, RO; Prados, MD; Sarkaria, JN; Vandenberg, SR | 1 |
| Ayers-Ringler, J; Berger, MS; Butowski, N; Carliner, H; Chang, SM; DeBoer, R; Fedoroff, A; Haas-Kogan, DA; James, CD; Kabuubi, P; Lamborn, KR; McDermott, MW; Page, M; Parsa, AT; Parvataneni, R; Prados, MD; Rabbitt, J; Sneed, PK; Stokoe, D; Vandenberg, S | 1 |
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| Battastini, AM; Braganhol, E; Brunetto, AL; Cechim, G; de Castro, CG; de Oliveira, MS; Lenz, G; Meurer, L; Roesler, R; Santos, DG; Schwarstmann, G; Schwartsmann, G | 1 |
| Garrett-Mayer, E; Giglio, P; Herrin, AE; Jenrette, JM; Marshall, DT; Patel, S; Watkins, JM | 1 |
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| Aikawa, E; Chen, JW; Figueiredo, JL; McCann, CM; Waterman, P; Weissleder, R | 1 |
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| Armstrong, TS; Bondy, M; Cao, Y; Gilbert, MR; Manning, R; Okcu, MF; Scheurer, ME; Vera-Bolaños, E; Zhou, R | 1 |
| Dohmen-Scheufler, H; Guzel, A; Maciaczyk, J; Nikkhah, G; Ostertag, CB; Senturk, S; Volk, B | 1 |
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| Bigner, DD; Desjardins, A; Friedman, AH; Friedman, HS; Gururangan, S; Herndon, JE; Jiang, SX; McLendon, RE; Quinn, JA; Reardon, DA; Rich, JN; Sampson, JH; Vredenburgh, JJ; Walker, A | 2 |
| Armand, JP; Baurain, JF; Brandes, AA; Campone, M; Carpentier, AF; Clement, PM; Frenay, M; Gorlia, T; Kletzl, H; Klughammer, B; Kouwenhoven, MC; Kros, JM; Lacombe, D; Rampling, R; Taphoorn, MJ; Tosoni, A; van den Bent, MJ | 1 |
| Adams, B; Maurer, GD; Stupp, R; Tabatabai, G; Tritschler, I; Weller, M; Wick, W | 1 |
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| Gerstner, ER; Lafrankie, D; McNamara, MB; Norden, AD; Wen, PY | 1 |
| Hoorens, A; Neyns, B; Stupp, R | 1 |
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| Hop, WC; Jeurissen, FJ; Roon, K; Taphoorn, MJ; Vecht, CJ; Zwinkels, H | 1 |
| Heppner, FL; Ingold, B; Moch, H; Schraml, P | 1 |
| Chen, L; Dinca, EB; James, CD; Kadoch, C; Karrim, J; Lowell, CA; Nguyen, D; Parikh, S; Rubenstein, JL; Shuman, MA; Treseler, PA; Voicu, R | 1 |
| Han, Y; Khramtsov, A; Lesniak, MS; Nandi, S; Sonabend, AM; Ulasov, IV | 1 |
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| Chen, TC; Golden, EB; Hofman, FM; Pen, L; Schönthal, AH; Sivakumar, W; Virrey, JJ; Wang, W | 1 |
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| Han, JH; Heo, DS; Jung, HW; Kim, CY; Kim, DG; Kim, DW; Kim, IH; Lee, SH; Paek, SH; Park, CK | 1 |
| Desjardins, A; Friedman, HS; Gururangan, S; Herndon, JE; Jiang, SX; McLendon, RE; Quinn, JA; Reardon, DA; Sampson, JH; Vredenburgh, JJ | 1 |
| Chang, S; Heimberger, A; McCoy, L; Patil, C; Patoka, J; Prados, M; Rice, T; Sampson, JH; Schwartzbaum, J; Wiemels, JL; Wiencke, JK; Wilson, D; Wrensch, M | 1 |
| Fukushima, T; Inoue, T; Komatsu, F; Ohmura, T; Ohta, M; Oshiro, S; Sakamoto, S; Tsugu, H | 1 |
| Bachoo, RM; Boothman, DA; Burma, S; Camacho, CV; Cavenee, WK; Furnari, F; Hatanpaa, KJ; Madden, C; Maher, E; McEllin, B; Mickey, B; Mukherjee, B; Nannepaga, S; Sirasanagandala, S; Tomimatsu, N | 1 |
| Chansakul, P; Ito, M; Kato, T; Kim, SU; Kondo, Y; Natsume, A; Ohno, M; Wakabayashi, T; Yokoyama, H; Yuki, K | 1 |
| Borget, I; Brignone, M; Cartalat-Carel, S; Chinot, O; Hassani, Y; Taillandier, L; Taillibert, S; Tilleul, P | 1 |
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| Fukushima, T; Katayama, Y; Naruse, N; Ogino, A; Ohta, T; Okamoto, Y; Sano, E; Watanabe, T; Yachi, K; Yoshino, A | 1 |
| Affronti, ML; Bigner, DD; Desjardins, A; Friedman, AH; Friedman, HS; Heery, CR; Herndon, JE; Reardon, DA; Rich, JN; Vredenburgh, JJ | 1 |
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| Hirose, Y; Kawase, T; Ohba, S; Sano, H | 1 |
| Desjardins, A; Friedman, AH; Friedman, HS; Herndon, JE; Jiang, SX; McLendon, RE; Quinn, JA; Reardon, DA; Sampson, JH; Vredenburgh, JJ | 1 |
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| Dubey, A; Erasmus, A; Gauden, AJ; Gauden, SJ; Hunn, A; Waites, P | 1 |
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| Jeon, HJ; Kim, JH; Kim, ST; Kim, WS; Kong, DS; Lee, JI; Lim, DH; Nam, DH; Park, K; Park, KB | 1 |
| Arora, B; Dutta, D; Gupta, T; Jalali, R; Kurkure, P; Munshi, A; Raut, N; Sarin, R | 1 |
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| Khuntia, D; Mehta, MP; Platta, CS; Suh, JH | 1 |
| Balducci, M; Calista, F; Cantore, GP; Cellini, N; Cilla, S; Deodato, F; Digesù, C; Esposito, V; Ferro, M; Ianiri, M; Macchia, G; Morganti, AG; Piermattei, A; Romanelli, P; Salvati, M; Valentini, V | 1 |
| Dresemann, G; Engel, E; Fluge, O; Heinrich, B; Hosius, C; Karup-Hansen, A; Krex, D; Mayer-Steinacker, R; Mehdorn, M; Nikolova, Z; Nowak, A; Olver, IN; Parker, R; Rosenthal, MA; Schleyer, E; Sieder, C; Sorenson, G; Steinbach, JP; Wagner, W; Wedding, U; Weller, M | 1 |
| Ballman, KA; Carlson, BL; Decker, PA; Giannini, C; Grogan, PT; James, CD; Kitange, GJ; Mladek, AC; Sarkaria, JN; Schroeder, MA; Wu, W | 1 |
| Chen, B; Jiang, T; Li, S; Wang, Z; Zhang, W | 1 |
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| Iwata, H; Shibamoto, Y; Sugie, C | 1 |
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| Clark, BL; Ervin, T; Friedman, E; Hainsworth, JD; Lamar, RE; Murphy, PB; Priego, V | 1 |
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| Archer, GE; Bigner, DD; Congdon, KL; Cui, X; Desjardins, A; Friedman, AH; Friedman, HS; Herndon, JE; McLendon, RE; Mitchell, DA; Reardon, DA; Sampson, JH; Sanchez-Perez, L; Schmittling, RJ; Snyder, DJ; Vredenburgh, JJ | 1 |
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| Desjardins, A; Friedman, HS; Lou, E; Peters, KB; Reardon, DA; Sampson, JH; Sumrall, A; Turner, S; Vredenburgh, JJ | 1 |
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| Butowski, N; Cha, S; Chang, SM; Essock-Burns, E; Lupo, JM; Molinaro, AM; Nelson, SJ | 1 |
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| Castel, T; Conill, C; Puig, S; Toscas, I | 1 |
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| Ebert, BL; Niemierko, E; Salgia, R; Shaffer, K | 1 |
| Kroll, M; Lu, HH; Lynch, GR; Massarweh, S; Sears, DA; Shahab, I; Teh, BS; Udden, MM | 1 |
| Baayen, HC; Barkhof, F; Boogerd, W; Castelijns, JA; Elkhuizen, PH; Heimans, JJ; Postma, TJ; Uitdehaag, BM; Vos, MJ | 1 |
| Baron, B; Boogerd, W; Bravo Marques, J; Chinot, O; De Beule, N; Kros, JM; Taphoorn, MJ; van den Bent, MJ; van der Rijt, CC; Vecht, CJ | 1 |
| Benita-Weiss, M; Bushunow, P; Coyle, TE; Evans, B; Friedman, H; Korones, DN; Mechtler, L; Quinn, JA; Reardon, DA | 1 |
| Barnett, G; Chahlavi, A; Elson, P; Kanner, A; Peereboom, D; Staugaitis, SM | 1 |
| Chou, TC; Dong, HJ; Figul, M; Rainov, NG; Söling, A | 1 |
| Friedman, HS; Houghton, PJ; Keir, ST | 1 |
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| Ardizzoni, A; Debruyne, C; Dziadziuszko, R; Giaccone, G; Legrand, C; Postmus, PE; Price, A; Smit, EF | 1 |
| Berger, MS; Bodell, WJ; Gaikwad, NW; Miller, D | 1 |
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| Foster, T; Newlands, ES; Zaknoen, S | 1 |
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| Chapman, PB; Foster, T; Houghton, AN; Hwu, WJ; Krown, SE; Lamb, LA; Livingston, PO; Menell, JH; Merrell, J; Panageas, KS; Quinn, CJ; Williams, LJ; Wolchok, JD | 1 |
| Fouladi, M; Gajjar, A; Heideman, RL; Kirstein, MN; Nair, G; Panetta, JC; Stewart, CF; Wilkinson, M | 1 |
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| Dolan, ME; Nagasubramanian, R | 1 |
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| Chang, SM; Lamborn, K; Malec, M; Page, M; Prados, MD; Rabbitt, J; Theodosopoulos, P | 1 |
| Chang, SM; Fine, HA; Fink, KL; Greenberg, HS; Hess, KR; Jaeckle, KA; Junck, L; Kuhn, J; Mehta, MP; Nicholas, MK; Prados, MD; Robins, HI; Schold, SC; Yung, WK | 1 |
| Ashley, DM; Cher, LM; Chua, SL; Dowling, A; Rosenthal, MA; Wong, SS; Woods, AM | 1 |
| Abson, C; Brada, M; Dzik-Jurasz, AS; Leach, MO; Murphy, PS; Rowland, IJ; Viviers, L | 1 |
| Boiardi, A; Broggi, G; Eoli, M; Lamperti, E; Maccagnano, E; Salmaggi, A; Silvani, A | 1 |
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| Chamberlain, MC; Tsao-Wei, DD | 1 |
| de Tribolet, N; Dietrich, PY; Diserens, AC; Godard, S; Hegi, ME; Ostermann, S; Otten, P; Regli, L; Stupp, R; Van Melle, G | 1 |
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| Castel, T; Conill, C; Fernández-Ibiza, J; Malvehy, J; Puig, S; Sánchez, M | 1 |
| Chang, SM; Fine, H; Fink, KL; Greenberg, H; Hess, K; Jaeckle, KA; Junck, L; Kuhn, J; Mehta, M; Prados, MD; Robins, HI; Schold, C; Yung, WK | 1 |
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| Buclin, T; Csajka, C; Decosterd, LA; Lejeune, F; Leyvraz, S; Ostermann, S; Stupp, R | 1 |
| Berger, MS; Hirose, Y; Katayama, M; Pieper, RO | 1 |
| Atkins, J; Bahary, JP; Barger, G; Buckner, J; Bushunow, P; Cairncross, G; Chang, SM; Choucair, A; Curran, W; Dolinskas, C; Gilbert, M; Kresl, J; Louis, DN; Mehta, M; Seiferheld, W; Share, R; Thoron, L | 1 |
| Ataman, F; Fisher, B; Mirimanoff, RO; Poortmans, P; Stupp, R | 1 |
| Couanet, D; Grill, J; Kalifa, C; Lelouch-Tubiana, A; Vassal, G; Verschuur, AC | 1 |
| Carpentier, A; Cartalat-Carel, S; Chinot, O; Cougnard, J; Delattre, JY; Djafari, L; Duffau, H; Gervais, H; Hoang-Xuan, K; Honnorat, J; Laigle, F; Mokhtari, K; Napolitano, M; Sanson, M; Taillandier, L; Taillibert, S | 1 |
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| Aguirre-Cruz, L; Arribas, L; Balaña, C; Esteller, M; García-Lopez, JL; García-Villanueva, M; Paz, MF; Piquer, J; Pollan, M; Reynes, G; Rojas-Marcos, I; Safont, MJ; Sanchez-Cespedes, M; Yaya-Tur, R | 1 |
| Balzarotti, M; Boiardi, A; Calatozzolo, C; Ciusani, E; Croci, D; Salmaggi, A | 1 |
| de Bruin, HG; de Wit, MC; Eijkenboom, W; Sillevis Smitt, PA; van den Bent, MJ | 1 |
| Bafaloukos, D; Briassoulis, E; Christodoulou, C; Fountzilas, G; Gogas, H; Hatzichristou, H; Kalofonos, HP; Linardou, H; Panagiotou, P; Tsoutsos, D | 1 |
| Abrey, LE; DeAngelis, LM; Demopoulos, A; Enting, RH | 1 |
| Allgeier, A; Brandes, AA; Enting, RH; Frenay, M; Kros, JM; Menten, J; Stege, EB; Taphoorn, MJ; Tosoni, A; Triebels, VH; van den Bent, MJ; van Heuvel, I | 1 |
| Aaltonen, K; Mäenpää, HO; Mäntylä, R; Minn, H | 1 |
| Gillespie, GY; Kufe, DW; Weichselbaum, RR; Yamini, B; Yu, X | 1 |
| Aryan, HE; Bruce, DA; Levy, ML; Lu, DC; Meltzer, HS; Ozgur, BM | 1 |
| Chang, SM; Lamborn, KR; Larson, D; Malec, M; Nicholas, MK; Page, M; Prados, MD; Rabbitt, J; Sneed, P; Wara, W | 1 |
| Leyvraz, S; Mirimanoff, RO; Ostermann, S; Pica, A; Stupp, R; Villemure, JG; Wasserfallen, JB | 1 |
| Bankiewicz, KS; Berger, MS; Bringas, JR; Panner, A; Pieper, RO; Saito, R; Tamas, M | 1 |
| Bartolomei, M; Bodei, L; Grana, C; Handkiewicz-Junak, D; Maira, G; Mazzetta, C; Paganelli, G; Rocca, P; Sturiale, C; Villa, G | 1 |
| Branle, F; Everaert, E; Joosens, E; Menten, J; Neyns, B; Strauven, T | 1 |
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| Peterson, RA; Rostomily, RC; Scharnhorst, JD; Silbergeld, DL; Spence, AM | 1 |
| Cereda, E; Gariboldi, MB; Monti, E; Ravizza, R | 1 |
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| Bookman, MA; Gallo, JM; Guo, P; Li, S; Ma, J; Orlansky, A; Pulfer, S; Vicini, P; Zhou, F | 1 |
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| Balaña, C; Balart, J; Ballester, R; Benavides, M; Berrocal, A; Capellades, J; Cerdá-Nicolás, M; García, JL; Herrero, A; López-Pousa, A; Martín-Broto, J; Yaya-Tur, R | 1 |
| Carminati, O; De Giorgi, U; Kopf, B; Marangolo, M; Rosti, G; Zago, S | 1 |
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| Aravantinos, G; Bafaloukos, D; Bamias, A; Carina, M; Christodoulou, C; Klouvas, G; Linardou, H; Skarlos, D | 1 |
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| Allgeier, A; Belanger, K; Bogdahn, U; Brandes, AA; Cairncross, JG; Curschmann, J; Eisenhauer, E; Fisher, B; Gorlia, T; Janzer, RC; Lacombe, D; Ludwin, SK; Marosi, C; Mason, WP; Mirimanoff, RO; Stupp, R; Taphoorn, MJ; van den Bent, MJ; Weller, M | 1 |
| Bromberg, JE; Cairncross, JG; de Tribolet, N; Diserens, AC; Gorlia, T; Hainfellner, JA; Hamou, MF; Hau, P; Hegi, ME; Janzer, RC; Kros, JM; Mariani, L; Mason, W; Mirimanoff, RO; Stupp, R; Weller, M | 1 |
| Antonadou, D; Athanassiou, H; Beroukas, K; Karageorgis, P; Maragoudakis, E; Misailidou, D; Paraskevaidis, M; Saris, G; Synodinou, M; Verigos, C | 1 |
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| Legha, SS | 1 |
| Chapman, PB; Houghton, AN; Hwu, WJ; Krown, SE; Lamb, LA; Lis, E; Livingston, PO; Menell, JH; Merrell, J; Panageas, KS; Williams, LJ; Wolchok, JD | 1 |
| Abrey, LE | 1 |
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| Combs, SE; Debus, J; Edler, L; Gutwein, S; Schulz-Ertner, D; Thilmann, C; van Kampen, M; Wannenmacher, MM | 1 |
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| Brock, C; Newlands, ES; Palmieri, C | 1 |
| Bromberg, JE; Postma, TJ | 1 |
| Enting, RH; Kros, JM; Sillevis Smitt, PA; Taal, W; van den Bent, MJ; van der Rijt, CD; van Heuvel, I | 1 |
| Abbruzzese, A; Addeo, R; Budillon, A; Caraglia, M; Costanzo, R; Del Prete, S; Faiola, V; Grillone, F; Marra, M; Montella, L; Palmieri, G; Tagliaferri, P; Venuta, S | 1 |
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| Aldape, K; Archer, GE; Bigner, DD; Crutcher, L; Dey, M; Gilbert, M; Hassenbusch, SJ; Heimberger, AB; Hussain, SF; Mitchell, DA; Sampson, JH; Sawaya, R; Schmittling, B; Sun, W | 1 |
| Asher, AL; Chang, SM; Croteau, D; Grahn, AY; Husain, SR; Kunwar, S; Lang, FF; Parker, K; Puri, RK; Sampson, JH; Shaffrey, M; Sherman, JW; Vogelbaum, MA | 1 |
| Claes, A; Heerschap, A; Jeuken, J; Leenders, WP; Maass, C; Wesseling, P | 1 |
| Al, MJ; Crott, R; Gorlia, T; Jin Seung, S; Lamers, LM; Mittmann, N; Stupp, R; Uyl-de Groot, CA; van den Bent, MJ; Wasserfallen, JB | 1 |
| Bergenheim, AT; Bergström, P; Henriksson, R; Johansson, M; Sandström, M | 1 |
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| Alavi, J; Balmaceda, C; Chen, J; Cheung, YK; Fine, RL; Fisher, PG; Pannullo, S; Peereboom, D; Sisti, M | 1 |
| Bozzao, A; De Paula, U; De Sanctis, V; Filippone, F; Lanzetta, G; Maurizi Enrici, R; Minniti, G; Muni, R; Osti, MF; Tombolini, V; Valeriani, M | 1 |
| Bischof, M; Combs, SE; Debus, J; Edler, L; Rausch, R; Schulz-Ertner, D; Wagner, F; Wagner, J; Welzel, T; Zabel-du Bois, A | 1 |
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| da Fonseca, CO; Fischer, J; Futuro, D; Gattass, CR; Nagel, J; Quirico-Santos, T; Schwartsmann, G | 1 |
| Bontempi, G; Debeir, O; Decaestecker, C; Haibe-Kains, B; Kiss, R; Le Mercier, M; Lefranc, F; Mathieu, V; Mijatovic, T | 1 |
| Benouaich-Amiel, A; Delattre, JY; Ducray, F; Idbaih, A; Laigle-Donadey, F; Rousseau, A; Sanson, M | 1 |
| Baumgart, U; Bogdahn, U; Hau, P; Hirschmann, B; Kunz-Schughart, L; Muhleisen, H; Reichle, A; Ruemmele, P; Steinbrecher, A; Weimann, E | 1 |
| Bael, TE; Gollob, JA; Peterson, BL | 1 |
| Nakamura, O; Saito, K; Shinoura, N; Tabei, Y; Takahashi, M; Yamada, R | 1 |
| Bergsneider, M; Cloughesy, T; Filka, E; Graham, C; Lai, A; Liau, LM; McGibbon, B; Mischel, P; Nghiemphu, PL; Pope, W; Selch, M; Yong, WH | 1 |
| Desjardins, A; Egorin, MJ; Friedman, AH; Friedman, HS; Gururangan, S; Herndon, JE; Lagattuta, TF; McLendon, R; Quinn, JA; Reardon, DA; Rich, JN; Salvado, AJ; Sathornsumetee, S; Vredenburgh, JJ | 1 |
| Blumenthal, DT; Chamberlain, MC; Glantz, MJ; Wei-Tsao, DD | 1 |
| Kleinberg, LR; Lin, SH | 1 |
| Ng, W; Steckley, JL; Watling, CJ | 1 |
| Mitchell, SB; Pan, E; Tsai, JS | 1 |
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| Bischof, M; Combs, SE; Debus, J; Edler, L; Nagy, M; Rausch, R; Schulz-Ertner, D; Welzel, T | 1 |
| Groves, MD; Katz, RL | 1 |
| Choi, JD; Friedman, AH; Powers, CJ; Sampson, JH; Vredenburgh, JJ | 1 |
| Batchelor, TT; Black, PM; Ciampa, A; Doherty, L; Drappatz, J; Folkman, J; Gigas, DC; Henson, JW; Kesari, S; Kieran, M; Laforme, A; Ligon, KL; Longtine, JA; Muzikansky, A; Ramakrishna, N; Schiff, D; Weaver, S; Wen, PY | 1 |
| Benveniste, RJ; Manzano, G; Petito, CK | 1 |
| Kawase, T; Sasaki, H; Yoshida, K | 1 |
| Bontempi, G; Decaestecker, C; Haibe-Kains, B; Kiss, R; Le Mercier, M; Lefranc, F; Mathieu, V; Mijatovic, T | 1 |
| Bertorelle, R; Blatt, V; Bonaldi, L; Brandes, AA; Ermani, M; Franceschi, E; Tosoni, A | 1 |
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| Burger, PC; Cochran, EJ; Gujrati, M; Holland, EC; Huse, JT; Jost, SC; Miller, CR; Perry, A; Qian, J; Raghavan, R; Rosenblum, MK; Scheithauer, BW; Zambrano, SC | 1 |
| Brandsma, D; Sminia, P; Stalpers, L; Taal, W; van den Bent, MJ | 1 |
| Bischof, M; Combs, SE; Debus, J; Hof, H; Oertel, S; Schulz-Ertner, D; Welzel, T | 1 |
| Liau, LM; Salgaller, ML | 1 |
| Belenky, ML; Buchsbaum, DJ; Fiveash, JB; Gillespie, GY; Oliver, PG; Zhou, T | 1 |
| Chamberlain, MC; Glantz, MJ | 1 |
| Adamson, PC; Blaney, SM; Flom, L; Ingle, AM; Jakacki, RI; Pollack, IF; Prados, MD; Timmerman, R; Yates, A; Zhou, T | 1 |
| Hagen, S; Klepp, O; Stridsklev, IC | 1 |
| Agrup, G; Arnbjörnsson, E; Hafström, L; Jönsson, PE; Rorsman, H | 1 |
| Chang, CH; Horton, J; Kramer, S; Nelson, JS; Perez-Tamayo, R; Salazer, O; Schoenfeld, D; Tsukada, Y; Weinstein, A | 1 |
| Giraldi, T; Grill, V; Mallardi, F; Perissin, L; Sava, G; Zorzet, S | 1 |
| Bianchi, R; Bonmassar, E; Fioretti, MC; Nardelli, B; Romani, L | 1 |
| Chiba, M; Homma, K; Jimbow, K; Kizukuri, K | 1 |
| Glaubiger, D; Nesbit, ME; Trigg, ME | 1 |
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| Dufour, FD; Mah, SG; Morton, DL; Okada, GT | 1 |
| Hafström, L; Jönsson, PE | 1 |
| A'Hern, R; Atkinson, H; Chang, J; Gore, ME; Lorentzos, A | 1 |
| Grever, MR; Koutsoukos, AD; Moore, TD; Plowman, J; Rubinstein, LV; Waud, WR | 1 |
| Dana, B; Daniels, DS; Fletcher, WS; Hutchins, LF; Hynes, HE; Pancoast, JR; Sondak, VK; Townsend, R | 1 |
| Czarnetzki, BM; Schadendorf, D; Worm, M | 1 |
| Newlands, ES; Stevens, MF | 1 |
| McVie, JG | 1 |
| Brampton, M; Colquhoun, IR; Glaser, MG; Illingworth, RD; Kennard, C; Lewis, P; Newlands, ES; O'Reilly, SM; Rice-Edwards, JM; Richards, PG | 1 |
| Ilveskoski, I; Lanning, M; Mäkipernaa, A; Perkkiö, M; Pihko, H; Saarinen, UM; Salmi, TT; Wiklund, T | 1 |
| Devineni, D; Gallo, JM; Klein-Szanto, A | 1 |
| Benoit, F; Bertheas, MF; Cambazard, F; Graille, MC; Guy, C; Lanthier, K; Perrot, JL | 1 |
| Anderson, CM; Buzaid, AC; Legha, SS | 1 |
| Bower, M; Brampton, MH; Brock, C; Colquhoun, I; Evans, H; Glaser, MG; Illingworth, RD; Lewis, P; Newlands, ES; O'Reilly, SM; Rice-Edwards, JM; Richards, PG | 1 |
| Glaser, MG; Marcus, K; Newlands, ES; Porteous, JK; Wedge, SR | 1 |
| de Mulder, PH; Jansen, RL; Muller, EW; Punt, CJ; van Herpen, CM; Vreugdenhil, G | 1 |
| Begent, RJ; Bleehen, NM; Bower, M; Brada, M; Brampton, MH; Calvert, H; Colquhoun, I; Lewis, P; Newlands, ES | 1 |
| Celli, P; Cervoni, L; Maraglino, C | 1 |
| Bassères, N; Bizzari, JP; Bonerandi, JJ; Gérard, B; Grob, JJ; Richard, MA; Zarrour, H | 1 |
| Bisighini, G; Di Lernia, V; Lo Scocco, G | 1 |
| Bower, M; Brampton, MH; Brock, CS; Colquhoun, I; Evans, H; Glaser, M; Newlands, ES; Roddie, M; Rustin, GJ; Wedge, SR | 1 |
| Bauer, J; Biollaz, J; Buclin, T; Decosterd, LA; Gander, M; Lejeune, F; Leyvraz, S; Marzolini, C; Shen, F | 1 |
| Dugan, M; Gerson, SL; Izbicka, E; Raymond, E; Soda, H; Von Hoff, DD | 1 |
| Berger, MS; Blank, A; Bobola, MS; Silber, JR; Tseng, SH | 1 |
| Ashley, DM; Bigner, DD; Bigner, SH; Cokgor, I; Colvin, OM; Dugan, M; Friedman, AH; Friedman, HS; Haglund, MM; Henry, AJ; Kerby, T; Krischer, J; Lovell, S; Marchev, F; McLendon, RE; Modrich, PL; Provenzale, JM; Rasheed, K; Rich, J; Seman, AJ; Stewart, E | 1 |
| Fuchs, T; Keilholz, U; Proebstle, TM; Scheibenbogen, C; Sterry, W | 1 |
| Fujii, E; Kasai, A; Kobayashi, K; Komada, F; Nakanishi, M; Onishi, H; Otsuji, A; Watanabe, M; Yasuda, M; Yokoyama, N | 1 |
| Darling, JL; Sankar, A; Thomas, DG | 1 |
| Burton, E; Prados, M | 1 |
| Belanich, M; Biollaz, J; Bonfanti, M; Colella, G; D'Incalci, M; Decosterd, L; Gander, M; Lejeune, F; Leyvraz, S; Liénard, D; Marzolini, C; Perey, L; Shen, F; Yarosh, D | 1 |
| Gademann, G; Gollnick, H; Ulrich, J | 1 |
| Miller, JL | 1 |
| Albright, R; Brada, M; Bruner, J; Chang, SM; Dugan, M; Friedman, AH; Friedman, HS; Levin, VA; O'Neill, AM; Olson, J; Prados, MD; Rosenfeld, SS; Yaya-Tur, R; Yue, N; Yung, WK; Zaknoen, S | 1 |
| Batra, V; Beale, P; Brada, M; Cutler, D; Dugan, M; Judson, I; Moore, S; Reidenberg, P; Statkevich, P | 1 |
| Brock, CS; Evans, H; Matthews, J; Newlands, ES; O'Reilly, SM; Osman, S; Price, PM; Young, H | 1 |
| Brada, M; Osoba, D; Prados, M; Yung, WK | 1 |
| Brent, TP; Friedman, HS; Houghton, PJ; Kirstein, MN; Middlemas, DS; Poquette, C; Stewart, CF | 1 |
| Ferreri, AJ; Landoni, C; Reni, M; Villa, E | 1 |
| MacConnachie, AM | 1 |
| Batchelor, T | 1 |
| Agarwala, SS; Kirkwood, JM | 1 |
| Allen, J; Becker, M; Gibbs, P; Gonzalez, R; Iannucci, A; McDowell, K; Murphy, J; O'Driscoll, M; Rosse, P; Williams, P | 1 |
| Heimans, JJ; Slotman, BJ; van den Berg, J; van der Valk, P; van Rijn, J | 1 |
| Friedman, HS | 1 |
| Prados, MD | 1 |
| Calvert, H; Friedman, HS; Kerby, T | 1 |
| Albright, RE; Brada, M; Bruner, J; Fink, K; Fredericks, R; Friedman, H; Glantz, M; Greenberg, H; Hohl, RJ; Levin, VA; Olson, J; Osoba, D; Phillips, P; Prados, MD; Rampling, R; Selker, RG; Shapiro, W; Spence, A; Vick, NA; Yue, N; Yung, WK; Zaknoen, S | 1 |
| Brada, M; Osoba, D; Prados, MD; Yung, WK | 1 |
| Brent, TP; Cheshire, PJ; Friedman, HS; Houghton, PJ; Kirstein, MN; Poquette, CA; Richmond, LB; Stewart, CF; Tan, M | 1 |
| Archer, GE; Bigner, DD; Friedman, AH; Friedman, HS; Heimberger, AB; Hulette, C; McLendon, RE; Sampson, JH | 1 |
| Osoba, D | 1 |
| Ames, MM; Buckner, JC; Hatfield, AK; Johnson, PS; Krook, JE; Morton, RF; Nair, S; Novotny, PJ; Rajkumar, SV; Reid, JM; Safgren, SL; Scheithauer, BW | 1 |
| Bacoyiannis, C; Bafaloukos, D; Bamias, A; Christodoulou, C; Karabelis, A; Kosmidis, P; Papakostas, P; Samantas, E; Skarlos, DV | 1 |
| Amistà, P; Basso, U; Berti, F; Brandes, AA; Ermani, M; Gardiman, M; Monfardini, S; Pinna, G; Rotilio, A; Scienza, R | 1 |
| Brada, M; Bravo-Marques, JM; Bruner, J; Dietrich, PY; Dirix, LY; Dugan, M; Heimans, JJ; Henriksson, R; Hoang-Xuan, K; Macdonald, D; Rampling, R; Rao, S; Stupp, R; Yue, N; Zaknoen, S; Zonnenberg, BA | 1 |
| Bosik, ME; Chang, SM; Fink, KL; Fulton, D; Kuhn, JG; Mehta, MP; Prados, MD; Robins, HI; Schold, SC; Spence, AM | 1 |
| Barrie, M; Braguer, D; Chinot, OL; Dufour, H; Figarella-Branger, D; Grisoli, F; Honore, S; Martin, PM; Muracciole, X | 1 |
| Frenkel, EP; Han, Q; Hoffman, RM; Kokkinakis, DM; Schold, SC; Tan, Y; Wick, JB; Xu, M | 1 |
| Cave, C; Dinnes, J; Huang, S; Major, K; Milne, R | 1 |
| Ashley, DL; Cher, L; Harris, MT; Rosenthal, MA | 1 |
| Frommhold, H; Koch, D; Liegibel, J; Lutterbach, J; Madlinger, A; Pagenstecher, A | 1 |
| Brandes, AA; Carpentier, AF; Eskens, FA; Keime-Guibert, F; Kros, JM; Taphoorn, MJ; van den Bent, MJ | 1 |
| Biasco, G; Casadei, S; Pantaleo, MA | 1 |
| Abrey, LE; Christodoulou, C | 1 |
| Chou, TC; Droege, JW; Fels, C; Kramm, CM; Rainov, NG; Schäfer, C | 1 |
| Abrey, LE; Boutros, DY; Mack, M; Malkin, MG; Olson, JD; Raizer, JJ; Rodavitch, A | 1 |
| Benjelloun, A; Delavelle, J; Dietrich, PY; Lazeyras, F | 1 |
| Abrey, LE; Bazylewicz, KA; Khan, RB; Malkin, MG; Raizer, JJ | 1 |
| Cansiz, H; Karakullukçu, B; Ozek, H; Oztürk, O | 1 |
| Bafaloukos, D; Briassoulis, E; Fountzilas, G; Georgoulias, V; Gogas, H; Kalofonos, Ch; Karabelis, A; Kosmidis, P; Samantas, E; Skarlos, D | 1 |
| Newton, HB; Santi, M; Stevens, C | 1 |
| de Tribolet, N; Dietrich, PY; Janzer, R; Leyvraz, S; Maeder, P; Maillard, I; Meuli, R; Miralbell, R; Mirimanoff, RO; Ostermann Kraljevic, S; Pica, A; Pizzolato, G; Porchet, F; Regli, L; Stupp, R | 1 |
| Groves, MD; Hess, KR; Jaeckle, KA; Levin, VA; Peterson, P; Puduvalli, VK; Yung, WK | 1 |
| Brada, M | 1 |
| Cave, C; Dinnes, J; Huang, S; Milne, R | 1 |
| Hwu, WJ; Lis, E; Panageas, KS; Raizer, J | 1 |
| Gander, M; Leyvraz, S; Newlands, E; Stupp, R | 1 |
| Hisada, T; Ito, T; Masuda, S; Mochida, A; Morinari, H; Nakahara, K; Nishi, K; Saito, K; Sasaki, S; Tahara, M; Yakumaru, K | 1 |
| Brampton, MH; Calvert, AH; Middleton, MR; Paul, MJ; Rustin, G; Summers, Y; Thatcher, N | 1 |
| Atkins, B; Clark, I; Dutcher, P; Ernstoff, S; Flaherty, L; Gollob, J; II Smith, W; Johnson, D; Longmate, J; Margolin, K; Sosman, J; Thompson, A; Weber, J; Weiss, G | 1 |
| Croteau, D; Mikkelsen, T | 1 |
| Pavelka, Z; Slampa, P; Sterba, J | 1 |
| Baker, LH; Izbicki, RM; Ratanatharathorn, V; Samson, MK | 1 |
| Baxter, D; Cunningham, TJ; Horton, J; Nelson, L; Olson, KB; Rosenbaum, C; Sponzo, RW; Taylor, SG | 1 |
| Colsky, J; Costanza, ME; Cunningham, T; Nathanson, L; Regelson, W; Schoenfeld, D; Sedransk, N; Wolter, J | 1 |
| Levin, VA; Wilson, CB | 1 |
| Beretta, G; Bonadonna, G; Cascinelli, N; Morabito, A; Veronesi, U | 1 |
| Gercovich, FG; Gottlieb, JA; Luna, MA | 1 |
| Chaitchik, S; Inbar, M; Kovner, F; Merimsky, O; Reider-Groswasser, I | 1 |
| Chaitchik, S; Gerard, B; Inbar, M; Merimsky, O | 1 |
| Chaitchik, S; Merimsky, O | 1 |
| Kan, S; Miyasaka, Y; Murata, K; Ohbu, M; Saito, M; Takagi, H; Takano, S; Yada, K | 1 |
| Avril, MF; Bertrand, P; Bizzari, JP; Cour, V; Gerard, B; Khayat, D | 1 |
| Crowther, D; Lee, SM; Margison, GP; Thatcher, N | 1 |
| de Vries, EG; Mulder, NH; Schraffordt Koops, H; Sleijfer, DT; Willemse, PH | 1 |
| Chaitchik, S; Inbar, M; Merimsky, O; Reider-Groswasser, I | 1 |
| Boaziz, C; Breau, JL; Israël, L; Morere, JF | 1 |
| Aisner, J; Antman, KH; Elias, A; Ryan, L | 1 |
| Aisner, J; Antman, KH; Collins, J; Elias, A; Ryan, L; Sulkes, A | 1 |
| Cangir, A; Goepfert, H; Lee, YY | 1 |
| Al-Sarraf, M; Athens, JW; Costanzi, JJ; Eltringham, JR; Eyre, HJ; Fletcher, WS; Gehan, EA; Oishi, N; Talley, RW; Vogel, FS | 1 |
| Bleyer, WA; Geyer, JR; Heideman, RL; Kosnik, EJ; Milstein, JM; Morris, JD; Mulne, AF; Pendergrass, TW; Ruymann, FB; Stuntz, JT | 1 |
| Antman, KH; Elias, AD | 1 |
| Haft, H; Wang, GC | 1 |
| Abe, H; Doi, S; Murai, H; Sawamura, Y; Tashiro, K | 1 |
| Brunat-Mentigny, M; Chastagner, P; Czorny, A; Lapras, C; Olive, D; Philip, T; Zucker, JM | 1 |
| Chessa, A; Desogus, A; Floris, C; Muggiano, A; Sulis, E; Tedde, A; Turno, R | 1 |
| Glaubiger, D; Levine, AS; Magrath, IT; Pizzo, PA; Poplack, DG; Srinivasan, U | 1 |
265 review(s) available for dacarbazine and Brain Neoplasms
| Article | Year |
|---|---|
Combining apatinib and temozolomide for brainstem glioblastoma: a case report and review of literature.
Topics: Adult; Brain Neoplasms; Brain Stem; Dacarbazine; Glioblastoma; Humans; Male; Pyridines; Temozolomide | 2022 |
Congress of Neurological Surgeons systematic review and evidence-based guidelines update on the role of cytotoxic chemotherapy and other cytotoxic therapies in the management of progressive glioblastoma in adults.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Glioblastoma; Humans; Neurosurgeons; Platinum Compounds; Temozolomide | 2022 |
Temozolomide Resistance: A Multifarious Review on Mechanisms Beyond
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; DNA; Glioblastoma; Humans; O(6)-Methylguanine-DNA Methyltransferase; Temozolomide | 2023 |
Newly Diagnosed Multifocal GBM: A Monocentric Experience and Literature Review.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Humans; Middle Aged; Retrospective Studies; Temozolomide | 2022 |
Comparative efficacy and safety of therapeutics for elderly glioblastoma patients: A Bayesian network analysis.
Topics: Aged; Antineoplastic Agents, Alkylating; Bayes Theorem; Brain Neoplasms; Dacarbazine; Glioblastoma; Humans; Lymphopenia; Neoplasm Recurrence, Local; Temozolomide | 2022 |
Glioblastoma Treatment: State-of-the-Art and Future Perspectives.
Topics: Bevacizumab; Brain Neoplasms; Dacarbazine; Glioblastoma; Humans; Temozolomide | 2022 |
Iron Oxide Nanoparticles Decorated with Functional Peptides for a Targeted siRNA Delivery to Glioma Cells.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; Drug Resistance, Neoplasm; Glioma; Humans; Magnetic Iron Oxide Nanoparticles; O(6)-Methylguanine-DNA Methyltransferase; Peptides; RNA, Small Interfering; Temozolomide | 2023 |
The impact of survivorship bias in glioblastoma research.
Topics: Aged; Biomarkers, Tumor; Brain Neoplasms; Dacarbazine; DNA Methylation; DNA Repair Enzymes; Glioblastoma; Humans; Prognosis; Survivorship; Temozolomide | 2023 |
Strategies increasing the effectiveness of temozolomide at various levels of anti-GBL therapy.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Glioblastoma; Glioma; Humans; Temozolomide | 2023 |
Implications of Advances in Studies of O
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; DNA; DNA Methylation; DNA Repair Enzymes; Glioblastoma; Humans; O(6)-Methylguanine-DNA Methyltransferase | 2023 |
Prolonged survival following everolimus combined with temozolomide for metastatic malignant melanoma with FBXW7 mutation: a case report and literature review.
Topics: Adult; Brain Neoplasms; Dacarbazine; Everolimus; F-Box-WD Repeat-Containing Protein 7; Humans; Male; Melanoma; Mutation; Temozolomide | 2021 |
Outcomes in Elderly Patients with Glioblastoma Multiforme Treated with Short-Course Radiation Alone Compared to Short-Course Radiation and Concurrent and Adjuvant Temozolomide Based on Performance Status and Extent of Resection.
Topics: Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Glioblastoma; Humans; Quality of Life; Retrospective Studies; Temozolomide | 2021 |
Does local drug delivery still hold therapeutic promise for brain cancer? A systematic review.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Drug Delivery Systems; Glioblastoma; Humans; Pharmaceutical Preparations | 2021 |
An overview of current results with the vincristine-irinotecan-temozolomide combination with or without bevacizumab in pediatric, adolescence and adult solid tumors.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Brain Neoplasms; Camptothecin; Child; Dacarbazine; Humans; Irinotecan; Neoplasms; Temozolomide; Vincristine | 2021 |
MGMT gene variants, temozolomide myelotoxicity and glioma risk. A concise literature survey including an illustrative case.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; Female; Glioma; Humans; Middle Aged; Pancytopenia; Polymorphism, Single Nucleotide; Prognosis; Temozolomide; Tumor Suppressor Proteins | 2017 |
The interventional effect of new drugs combined with the Stupp protocol on glioblastoma: A network meta-analysis.
Topics: Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Glioblastoma; Humans; Network Meta-Analysis; Randomized Controlled Trials as Topic; Temozolomide; Treatment Outcome | 2017 |
Managing Glioblastoma in the Elderly Patient: New Opportunities.
Topics: Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemotherapy, Adjuvant; Dacarbazine; Disease Management; Glioblastoma; Humans; Neurosurgical Procedures; Prognosis; Radiotherapy; Temozolomide | 2017 |
Complete durable response of a pediatric anaplastic oligodendroglioma to temozolomide alone: Case report and review of literature.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Child; Dacarbazine; Humans; Isocitrate Dehydrogenase; Male; Oligodendroglioma; Temozolomide | 2017 |
Combined treatment for non-small cell lung cancer and breast cancer patients with brain metastases with whole brain radiotherapy and temozolomide: a systematic review and meta-analysis.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Chemoradiotherapy; Dacarbazine; Humans; Lung Neoplasms; Randomized Controlled Trials as Topic; Temozolomide | 2017 |
Procarbazine, lomustine and vincristine for recurrent high-grade glioma.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cytarabine; Dacarbazine; Disease Progression; Disease-Free Survival; Drug Administration Schedule; Glioma; Humans; Hydroxyurea; Lomustine; Methylprednisolone; Middle Aged; Neoplasm Recurrence, Local; Procarbazine; Randomized Controlled Trials as Topic; Temozolomide; Vincristine | 2017 |
Glioblastoma in the elderly: initial management.
Topics: Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemotherapy, Adjuvant; Clinical Trials, Phase III as Topic; Combined Modality Therapy; Dacarbazine; Glioblastoma; Humans; Prognosis; Radiation Dose Hypofractionation; Randomized Controlled Trials as Topic; Temozolomide | 2017 |
Tumor treating fields: a novel and effective therapy for glioblastoma: mechanism, efficacy, safety and future perspectives.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Clinical Trials, Phase III as Topic; Combined Modality Therapy; Dacarbazine; Disease-Free Survival; Electric Stimulation Therapy; Glioblastoma; Humans; Randomized Controlled Trials as Topic; Safety; Temozolomide; Treatment Outcome; United States | 2017 |
Regression of Recurrent High-Grade Glioma with Temozolomide, Dexamethasone, and Levetiracetam: Case Report and Review of the Literature.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Chemoradiotherapy; Corpus Callosum; Craniotomy; Dacarbazine; Decompression, Surgical; Dexamethasone; Female; Humans; Levetiracetam; Magnetic Resonance Imaging; Neoplasm Recurrence, Local; Oligodendroglioma; Piracetam; Remission Induction; Temozolomide; Tomography, X-Ray Computed | 2017 |
Treatment of Glioblastoma.
Topics: Aftercare; Age Factors; Angiogenesis Inhibitors; Antineoplastic Agents, Alkylating; Bevacizumab; Brain Neoplasms; Chemoradiotherapy, Adjuvant; Chemotherapy, Adjuvant; Cranial Irradiation; Cytoreduction Surgical Procedures; Dacarbazine; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Glioblastoma; Humans; Isocitrate Dehydrogenase; Magnetic Resonance Imaging; Mutation; Neoplasm Recurrence, Local; Neurosurgical Procedures; Promoter Regions, Genetic; Radiotherapy, Adjuvant; Temozolomide; Tumor Suppressor Proteins | 2017 |
Carmustine wafer implantation for high-grade gliomas: Evidence-based safety efficacy and practical recommendations from the Neuro-oncology Club of the French Society of Neurosurgery.
Topics: Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carmustine; Chemoradiotherapy; Combined Modality Therapy; Dacarbazine; Dosage Forms; Glioma; Humans; Neoplasm Recurrence, Local; Neurosurgical Procedures; Quality of Life; Randomized Controlled Trials as Topic; Temozolomide | 2017 |
Fractionated Radiotherapy of Intracranial Gliomas.
Topics: Adult; Brain Neoplasms; Dacarbazine; Dose Fractionation, Radiation; Glioblastoma; Glioma; Humans; Male; Middle Aged; Radiotherapy Dosage; Temozolomide | 2018 |
Chemotherapy of High-Grade Astrocytomas in Adults.
Topics: Adult; Astrocytoma; Brain Neoplasms; Dacarbazine; Glioblastoma; Glioma; Humans; Neoplasm Grading; Temozolomide | 2018 |
An Interplay between Senescence, Apoptosis and Autophagy in Glioblastoma Multiforme-Role in Pathogenesis and Therapeutic Perspective.
Topics: Animals; Antineoplastic Agents, Alkylating; Apoptosis; Autophagy; Brain Neoplasms; Cellular Senescence; Dacarbazine; Disease Models, Animal; DNA Damage; Glioblastoma; Humans; Mice; Resveratrol; Stilbenes; Temozolomide | 2018 |
Opposite Interplay Between the Canonical WNT/β-Catenin Pathway and PPAR Gamma: A Potential Therapeutic Target in Gliomas.
Topics: Animals; Brain Neoplasms; Dacarbazine; Down-Regulation; Glioma; Humans; PPAR gamma; Temozolomide; Wnt Signaling Pathway | 2018 |
Alternating Electric Fields Therapy for Malignant Gliomas: From Bench Observation to Clinical Reality.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Electric Stimulation Therapy; Electromagnetic Fields; Glioma; Humans; Mitosis; Neoplasm Recurrence, Local; Temozolomide | 2018 |
Treatment of Glioblastoma in the Elderly.
Topics: Aged; Brain Neoplasms; Chemotherapy, Adjuvant; Dacarbazine; Glioblastoma; Humans; O(6)-Methylguanine-DNA Methyltransferase; Prognosis; Quality of Life; Temozolomide | 2018 |
Drug resistance in glioblastoma and cytotoxicity of seaweed compounds, alone and in combination with anticancer drugs: A mini review.
Topics: Antineoplastic Agents, Alkylating; Apoptosis; Brain Neoplasms; Dacarbazine; Drug Resistance, Neoplasm; Glioblastoma; Humans; Phloroglucinol; Seaweed; Temozolomide; Xanthophylls | 2018 |
Anti-angiogenic therapy for high-grade glioma.
Topics: Angiogenesis Inhibitors; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Bevacizumab; Brain Neoplasms; Camptothecin; Dacarbazine; Glioblastoma; Humans; Hypertension; Irinotecan; Lomustine; Neoplasm Recurrence, Local; Neovascularization, Pathologic; Progression-Free Survival; Proteinuria; Randomized Controlled Trials as Topic; Snake Venoms; Temozolomide | 2018 |
The combination of carmustine wafers and temozolomide for the treatment of malignant gliomas. A comprehensive review of the rationale and clinical experience.
Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carmustine; Clinical Trials as Topic; Dacarbazine; Glioma; Humans; Prognosis; Temozolomide | 2013 |
Essential role of Gli proteins in glioblastoma multiforme.
Topics: Antineoplastic Agents; Brain Neoplasms; Dacarbazine; Drug Resistance, Neoplasm; Glioblastoma; Hedgehog Proteins; Humans; Neoplastic Stem Cells; Signal Transduction; Temozolomide; Transcription Factors; Zinc Finger Protein GLI1 | 2013 |
Pseudoprogression after glioma therapy: a comprehensive review.
Topics: Antineoplastic Agents; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Disease Progression; Glioma; Humans; Neoplasm Recurrence, Local; Radiation Injuries; Radiotherapy; Temozolomide | 2013 |
A conceptually new treatment approach for relapsed glioblastoma: coordinated undermining of survival paths with nine repurposed drugs (CUSP9) by the International Initiative for Accelerated Improvement of Glioblastoma Care.
Topics: Antineoplastic Combined Chemotherapy Protocols; Aprepitant; Artemisinins; Auranofin; Brain Neoplasms; Captopril; Dacarbazine; Disulfiram; Glioblastoma; Gluconates; Humans; Ketoconazole; Morpholines; Nelfinavir; Neoplasm Recurrence, Local; Sertraline; Succinates; Temozolomide | 2013 |
Temozolomide for high grade glioma.
Topics: Age Factors; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Glioblastoma; Humans; Neoplasm Grading; Neoplasm Recurrence, Local; Randomized Controlled Trials as Topic; Survival Analysis; Temozolomide | 2013 |
Treatment recommendations for anaplastic oligodendrogliomas that are codeleted.
Topics: Brain Neoplasms; Dacarbazine; Humans; Isocitrate Dehydrogenase; Mutation; Oligodendroglioma; Temozolomide | 2013 |
Epigenetic pathways and glioblastoma treatment.
Topics: Adult; Animals; Brain Neoplasms; Dacarbazine; Drug Discovery; Epigenesis, Genetic; Gene Regulatory Networks; Glioblastoma; Humans; Mice; Molecular Targeted Therapy; Neoplasm Recurrence, Local; Systems Biology; Temozolomide | 2013 |
Update in the treatment of high-grade Gliomas.
Topics: Antineoplastic Agents; Brain Neoplasms; Dacarbazine; Drug Therapy, Combination; Glioma; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Radiotherapy; Temozolomide | 2013 |
Radiotherapy plus concurrent or sequential temozolomide for glioblastoma in the elderly: a meta-analysis.
Topics: Aged; Antineoplastic Agents; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Glioblastoma; Humans; Temozolomide | 2013 |
Elderly patients with glioblastoma: the treatment challenge.
Topics: Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Glioblastoma; Humans; Prognosis; Temozolomide | 2013 |
O6-methylguanine DNA methyltransferase as a promising target for the treatment of temozolomide-resistant gliomas.
Topics: Animals; Brain Neoplasms; Dacarbazine; Drug Resistance, Neoplasm; Glioma; Humans; Molecular Targeted Therapy; O(6)-Methylguanine-DNA Methyltransferase; Temozolomide | 2013 |
A meta-analysis of temozolomide versus radiotherapy in elderly glioblastoma patients.
Topics: Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Databases, Bibliographic; Glioblastoma; Humans; Outcome Assessment, Health Care; Randomized Controlled Trials as Topic; Temozolomide | 2014 |
Radiation and concomitant chemotherapy for patients with glioblastoma multiforme.
Topics: Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemoradiotherapy; Dacarbazine; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Dose Fractionation, Radiation; Glioblastoma; Humans; Radiosurgery; Temozolomide; Tumor Suppressor Proteins | 2014 |
High-grade glioma in elderly patients: can the oncogeriatrician help?
Topics: Age Factors; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Glioma; Humans; Prognosis; Temozolomide | 2013 |
Radiotherapy of high-grade gliomas: current standards and new concepts, innovations in imaging and radiotherapy, and new therapeutic approaches.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Diffusion Tensor Imaging; Glioblastoma; Glioma; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Neoplasm Grading; Particle Accelerators; Positron-Emission Tomography; Radiotherapy Dosage; Radiotherapy, Intensity-Modulated; Temozolomide | 2014 |
MicroRNA as potential modulators in chemoresistant high-grade gliomas.
Topics: Antineoplastic Agents; Brain Neoplasms; Dacarbazine; Drug Resistance, Neoplasm; Glioma; Humans; MicroRNAs; Neoplasm Grading; Temozolomide | 2014 |
Treatment options and outcomes for glioblastoma in the elderly patient.
Topics: Age Factors; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Glioblastoma; Humans; Middle Aged; Prognosis; Temozolomide; Treatment Outcome | 2014 |
[Radiotherapy plus concomitant systemic therapies for patients with brain metastases from breast cancer].
Topics: Angiogenesis Inhibitors; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Blood-Brain Barrier; Brain Neoplasms; Breast Neoplasms; Capecitabine; Chemotherapy, Adjuvant; Cisplatin; Clinical Trials, Phase II as Topic; Dacarbazine; Deoxycytidine; Female; Fluorouracil; Humans; Lapatinib; Protein Kinase Inhibitors; Quinazolines; Radiotherapy, Adjuvant; Receptor, ErbB-2; Temozolomide; Thalidomide; Topoisomerase I Inhibitors; Topotecan; Trastuzumab; Vinblastine; Vinorelbine | 2014 |
The role of cytotoxic chemotherapy in the management of progressive glioblastoma : a systematic review and evidence-based clinical practice guideline.
Topics: Absorbable Implants; Adult; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carmustine; Chemotherapy, Adjuvant; Dacarbazine; Disease Progression; Evidence-Based Medicine; Glioblastoma; Humans; Temozolomide | 2014 |
Straying from the path in neuro-oncology.
Topics: Brain Neoplasms; Clinical Trials as Topic; Dacarbazine; Humans; Medical Oncology; Temozolomide | 2014 |
Current evidence of temozolomide and bevacizumab in treatment of gliomas.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Brain Neoplasms; Cell Death; Combined Modality Therapy; Dacarbazine; Glioma; Humans; Neoplasm Recurrence, Local; Temozolomide | 2015 |
Predictive biomarkers investigated in glioblastoma.
Topics: Angiogenesis Inhibitors; Antineoplastic Agents, Alkylating; Biomarkers, Tumor; Brain Neoplasms; Dacarbazine; DNA Methylation; ErbB Receptors; Glioblastoma; Humans; Molecular Targeted Therapy; O(6)-Methylguanine-DNA Methyltransferase; Promoter Regions, Genetic; Temozolomide | 2014 |
Molecular neuro-oncology and the challenge of the blood-brain barrier.
Topics: Animals; Blood-Brain Barrier; Brain Neoplasms; Chromosome Deletion; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; Drug Delivery Systems; Glioblastoma; Humans; Isocitrate Dehydrogenase; Molecular Targeted Therapy; Proto-Oncogene Proteins B-raf; Temozolomide; Tumor Suppressor Proteins | 2014 |
[Management of gliomas].
Topics: Age Factors; Antibodies, Monoclonal, Humanized; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Brain Neoplasms; Chemoradiotherapy; Chromosome Deletion; Chromosomes, Human, Pair 1; Clinical Trials as Topic; Combined Modality Therapy; Dacarbazine; Dose Fractionation, Radiation; Drug Resistance, Neoplasm; Glioma; Humans; Lomustine; Methylation; Multicenter Studies as Topic; Neoplasm Proteins; Neurosurgical Procedures; O(6)-Methylguanine-DNA Methyltransferase; Procarbazine; Radiotherapy Dosage; Radiotherapy, Intensity-Modulated; Temozolomide; Treatment Outcome; Vincristine | 2014 |
Management of high-grade gliomas in the elderly.
Topics: Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Disease Management; Glioma; Humans; Temozolomide | 2014 |
Treatment of brain metastases.
Topics: Angiogenesis Inhibitors; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Bevacizumab; Brain Neoplasms; Chemotherapy, Adjuvant; Cranial Irradiation; Dacarbazine; Humans; Ipilimumab; Neurosurgical Procedures; Prognosis; Radiosurgery; Radiotherapy, Adjuvant; Risk Assessment; Risk Factors; Temozolomide | 2014 |
Antiangiogenic therapy for high-grade glioma.
Topics: Angiogenesis Inhibitors; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Bevacizumab; Brain Neoplasms; Camptothecin; Dacarbazine; Glioblastoma; Humans; Hypertension; Irinotecan; Lomustine; Neoplasm Recurrence, Local; Neovascularization, Pathologic; Proteinuria; Randomized Controlled Trials as Topic; Snake Venoms; Temozolomide | 2014 |
Emerging therapies for glioblastoma.
Topics: Animals; Blood-Brain Barrier; Brain Neoplasms; Cell- and Tissue-Based Therapy; Dacarbazine; Glioblastoma; Humans; Immunotherapy; Temozolomide | 2014 |
Comprehensive analysis of temozolomide treatment for patients with glioma.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Glioma; Humans; Prognosis; Temozolomide | 2014 |
Glioblastoma survival: has it improved? Evidence from population-based studies.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Community Health Planning; Dacarbazine; Glioblastoma; Humans; Temozolomide | 2014 |
Treatment considerations for MGMT-unmethylated glioblastoma.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Glioblastoma; Humans; Neoplasm Recurrence, Local; Prognosis; Promoter Regions, Genetic; Temozolomide; Tumor Suppressor Proteins | 2015 |
Economics of Malignant Gliomas: A Critical Review.
Topics: Brain Neoplasms; Canada; Cost of Illness; Costs and Cost Analysis; Dacarbazine; Drug Therapy; Europe; Glioma; Humans; Radiotherapy; Temozolomide; United States | 2015 |
Glioblastoma in the elderly.
Topics: Aged; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; Glioblastoma; Humans; Isocitrate Dehydrogenase; Temozolomide; Tumor Suppressor Proteins | 2015 |
Astrocytoma malignum in glioblastoma multiforme vertens with long term survival--case report and a literature review.
Topics: Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Chemoradiotherapy, Adjuvant; Craniotomy; Dacarbazine; Frontal Lobe; Glioblastoma; Humans; Magnetic Resonance Imaging; Male; Neoplasms, Second Primary; Prognosis; Remission Induction; Temozolomide | 2014 |
The evolution of the EGFRvIII (rindopepimut) immunotherapy for glioblastoma multiforme patients.
Topics: Animals; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Blood-Brain Barrier; Brain Neoplasms; Camptothecin; Cancer Vaccines; Chemoradiotherapy; Dacarbazine; Disease-Free Survival; ErbB Receptors; Glioblastoma; Humans; Immunotherapy; Irinotecan; Mice; Temozolomide; Vaccination; Vaccines, Subunit | 2014 |
[Systemic treatment of melanoma brain metastases].
Topics: Abatacept; Angiogenesis Inhibitors; Antibodies, Monoclonal; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Clinical Trials, Phase II as Topic; CTLA-4 Antigen; Dacarbazine; Humans; Imidazoles; Immunoconjugates; Immunotherapy; Indoles; Interleukin-2; Ipilimumab; Melanoma; Molecular Targeted Therapy; Neoplasm Proteins; Oximes; Point Mutation; Protein Kinase Inhibitors; Proto-Oncogene Mas; Proto-Oncogene Proteins B-raf; Sulfonamides; Vemurafenib | 2015 |
[Elderly patients with glioblastoma: state of the art].
Topics: Age Factors; Aged; Antibodies, Monoclonal, Humanized; Antineoplastic Agents, Alkylating; Bevacizumab; Brain Neoplasms; Dacarbazine; Glioblastoma; Humans; Prognosis; Radiotherapy, Adjuvant; Temozolomide | 2015 |
Toward an effective strategy in glioblastoma treatment. Part I: resistance mechanisms and strategies to overcome resistance of glioblastoma to temozolomide.
Topics: Animals; Antineoplastic Agents, Alkylating; Biomarkers, Tumor; Brain Neoplasms; Dacarbazine; Drug Design; Drug Resistance, Neoplasm; Genetic Predisposition to Disease; Glioblastoma; Humans; Molecular Structure; Phenotype; Signal Transduction; Structure-Activity Relationship; Temozolomide | 2015 |
Severe cholestatic hepatitis due to temozolomide: an adverse drug effect to keep in mind. Case report and review of literature.
Topics: Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemical and Drug Induced Liver Injury; Cholestasis; Dacarbazine; Fatal Outcome; Glioblastoma; Humans; Male; Temozolomide | 2015 |
Low-grade gliomas.
Topics: Antineoplastic Agents; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Disease Progression; Glioma; Humans; Isocitrate Dehydrogenase; Lomustine; Mutation; Procarbazine; Temozolomide; Treatment Outcome; Vincristine | 2015 |
Long-term temozolomide might be an optimal choice for patient with multifocal glioblastoma, especially with deep-seated structure involvement: a case report and literature review.
Topics: Adult; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemoradiotherapy; Combined Modality Therapy; Dacarbazine; Glioblastoma; Humans; Male; Neoplasm Staging; Prognosis; Temozolomide | 2015 |
Toward an effective strategy in glioblastoma treatment. Part II: RNA interference as a promising way to sensitize glioblastomas to temozolomide.
Topics: Animals; Antineoplastic Agents, Alkylating; Biomarkers, Tumor; Brain Neoplasms; Dacarbazine; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Gene Transfer Techniques; Humans; RNAi Therapeutics; Temozolomide | 2015 |
Chemoresistance and chemotherapy targeting stem-like cells in malignant glioma.
Topics: Animals; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; DNA Mismatch Repair; DNA Modification Methylases; DNA Repair Enzymes; Drug Resistance, Neoplasm; Glioma; Humans; Neoplastic Stem Cells; Temozolomide; Tumor Suppressor Proteins | 2015 |
Therapeutic management of gliosarcoma in the temozolomide era.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Disease Management; Gliosarcoma; Humans; Temozolomide | 2015 |
Economic Evaluation of Bevacizumab for the First-Line Treatment of Newly Diagnosed Glioblastoma Multiforme.
Topics: Angiogenesis Inhibitors; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Brain Neoplasms; Canada; Chemoradiotherapy; Cost-Benefit Analysis; Dacarbazine; Disease Progression; Disease-Free Survival; Drug Costs; Glioblastoma; Health Resources; Humans; Kaplan-Meier Estimate; Markov Chains; Models, Economic; Quality-Adjusted Life Years; Temozolomide; Time Factors; Treatment Outcome | 2015 |
Intracranial fibrosarcoma treated with adjuvant radiation and temozolomide: Report of a case and review of all published cases.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemotherapy, Adjuvant; Child; Child, Preschool; Craniotomy; Dacarbazine; Female; Fibrosarcoma; Humans; Infant; Magnetic Resonance Imaging; Male; Middle Aged; Neoplasm Recurrence, Local; Prognosis; Radiotherapy, Adjuvant; Rare Diseases; Survival Analysis; Temozolomide; Treatment Outcome; Young Adult | 2016 |
The efficacy and safety of various dose-dense regimens of temozolomide for recurrent high-grade glioma: a systematic review with meta-analysis.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Glioma; Humans; Neoplasm Recurrence, Local; Temozolomide | 2015 |
Temozolomide for Treating Malignant Melanoma.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Humans; Melanoma; Melanoma, Cutaneous Malignant; Quality of Life; Skin Neoplasms; Temozolomide; Treatment Outcome | 2015 |
Comparison of the effectiveness of whole-brain radiotherapy plus temozolomide versus whole-brain radiotherapy in treating brain metastases based on a systematic review of randomized controlled trials.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Humans; Randomized Controlled Trials as Topic; Temozolomide | 2016 |
An Update on the Role of Immunotherapy and Vaccine Strategies for Primary Brain Tumors.
Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cancer Vaccines; Combined Modality Therapy; Dacarbazine; Glioblastoma; Humans; Immunotherapy; Practice Guidelines as Topic; Prognosis; Radiotherapy, Adjuvant; Survival Rate; Temozolomide; Tissue Extracts | 2015 |
Procarbazine, lomustine and vincristine or temozolomide: which is the better regimen?
Topics: Antineoplastic Agents; Brain Neoplasms; Clinical Trials as Topic; Dacarbazine; Humans; Lomustine; Oligodendroglioma; Procarbazine; Temozolomide; Treatment Outcome; Vincristine | 2015 |
Guidelines, "minimal requirements" and standard of care in glioblastoma around the Mediterranean Area: A report from the AROME (Association of Radiotherapy and Oncology of the Mediterranean arEa) Neuro-Oncology working party.
Topics: Adult; Africa, Northern; Brain Neoplasms; Dacarbazine; Glioblastoma; Humans; Medical Oncology; Mediterranean Region; Neurology; Practice Guidelines as Topic; Quality of Life; Radiotherapy; Societies, Medical; Standard of Care; Temozolomide | 2016 |
How I treat glioblastoma in older patients.
Topics: Adult; Aged; Aged, 80 and over; Anticonvulsants; Antineoplastic Agents, Alkylating; Biomarkers, Tumor; Brain Neoplasms; Chemoradiotherapy, Adjuvant; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; Geriatric Assessment; Glioblastoma; Humans; Isocitrate Dehydrogenase; Methylation; Middle Aged; Prognosis; Promoter Regions, Genetic; Quality of Life; Seizures; Standard of Care; Temozolomide; Tumor Suppressor Proteins | 2016 |
Targeting autophagy to sensitive glioma to temozolomide treatment.
Topics: Antineoplastic Combined Chemotherapy Protocols; Autophagy; Brain Neoplasms; Cell Line, Tumor; Cell Survival; Chloroquine; Clinical Trials as Topic; Dacarbazine; Drug Resistance, Neoplasm; Drug Synergism; Glioblastoma; Humans; Sirolimus; Temozolomide | 2016 |
Therapeutic interactions of autophagy with radiation and temozolomide in glioblastoma: evidence and issues to resolve.
Topics: Antineoplastic Agents, Alkylating; Apoptosis; Autophagy; Brain Neoplasms; Dacarbazine; Glioblastoma; Humans; Radiation-Sensitizing Agents; Radiotherapy; Temozolomide | 2016 |
Brain Radiotherapy plus Concurrent Temozolomide versus Radiotherapy Alone for Patients with Brain Metastases: A Meta-Analysis.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Humans; Temozolomide; Treatment Outcome | 2016 |
Low-grade and anaplastic oligodendroglioma.
Topics: Antineoplastic Agents; Brain Neoplasms; Chemotherapy, Adjuvant; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; Humans; Isocitrate Dehydrogenase; Mutation; Oligodendroglioma; Procarbazine; Temozolomide; Tumor Suppressor Proteins; Vincristine | 2016 |
Cytomegalovirus-targeted immunotherapy and glioblastoma: hype or hope?
Topics: Animals; Brain Neoplasms; Cytomegalovirus; Cytomegalovirus Infections; Dacarbazine; Glioblastoma; Humans; Immunotherapy; Temozolomide | 2016 |
Pharmacotherapies for the treatment of glioblastoma - current evidence and perspectives.
Topics: Bevacizumab; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Glioblastoma; Humans; Neovascularization, Pathologic; Snake Venoms; Temozolomide | 2016 |
Effects of Temozolomide and Radiotherapy on Brain Metastatic Tumor: A Systematic Review and Meta-Analysis.
Topics: Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Dacarbazine; Databases, Bibliographic; Disease-Free Survival; Humans; Radiotherapy; Randomized Controlled Trials as Topic; Temozolomide | 2016 |
Problems of Glioblastoma Multiforme Drug Resistance.
Topics: Animals; Antineoplastic Agents, Alkylating; Blood-Brain Barrier; Brain; Brain Neoplasms; Dacarbazine; Drug Resistance, Neoplasm; Epigenesis, Genetic; Glioblastoma; Humans; Temozolomide | 2016 |
A network meta-analysis: the overall and progression-free survival of glioma patients treated by different chemotherapeutic interventions combined with radiation therapy (RT).
Topics: Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Bayes Theorem; Bevacizumab; Brain Neoplasms; Chemoradiotherapy; Cisplatin; Dacarbazine; Disease-Free Survival; Eflornithine; Glioma; Humans; Mitolactol; Network Meta-Analysis; Nimustine; Probability; Randomized Controlled Trials as Topic; Snake Venoms; Temozolomide; Treatment Outcome; Vincristine | 2016 |
A case of papillary tumor of the pineal region with a long clinical history: molecular characterization and therapeutic consideration with review of the literature.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Humans; Magnetic Resonance Imaging; Male; Neoplasm Recurrence, Local; Neurosurgical Procedures; Pineal Gland; Pinealoma; Radiotherapy, Adjuvant; Radiotherapy, Intensity-Modulated; Temozolomide | 2016 |
O
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Carcinogenesis; Carcinoma, Non-Small-Cell Lung; Dacarbazine; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Epigenomics; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Neuroendocrine Tumors; O(6)-Methylguanine-DNA Methyltransferase; Predictive Value of Tests; Prognosis; Promoter Regions, Genetic; Small Cell Lung Carcinoma; Temozolomide; Treatment Outcome; Tumor Suppressor Proteins | 2017 |
Gliadel wafer implantation combined with standard radiotherapy and concurrent followed by adjuvant temozolomide for treatment of newly diagnosed high-grade glioma: a systematic literature review.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Carmustine; Chemoradiotherapy; Chemotherapy, Adjuvant; Clinical Trials, Phase III as Topic; Combined Modality Therapy; Dacarbazine; Decanoic Acids; Disease-Free Survival; Drug Implants; Glioblastoma; Humans; Middle Aged; Neoplasm Grading; Polyesters; Temozolomide; United States; United States Food and Drug Administration | 2016 |
A state-of-the-art review and guidelines for tumor treating fields treatment planning and patient follow-up in glioblastoma.
Topics: Algorithms; Antineoplastic Agents, Alkylating; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Female; Follow-Up Studies; Glioblastoma; Humans; Magnetic Field Therapy; Magnetic Resonance Imaging; Male; Practice Guidelines as Topic; Temozolomide | 2017 |
Current management of low-grade gliomas.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Disease-Free Survival; Glioma; Humans; Mutation; Prognosis; Temozolomide; Treatment Outcome | 2016 |
Microglia in Cancer: For Good or for Bad?
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Communication; Cytokines; Dacarbazine; ErbB Receptors; Gamma Rays; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Macrophages; Microglia; Oligodeoxyribonucleotides; Signal Transduction; Temozolomide; Treatment Failure; Tumor Microenvironment | 2016 |
The prognostic value of MGMT promoter status by pyrosequencing assay for glioblastoma patients' survival: a meta-analysis.
Topics: Antineoplastic Agents, Alkylating; Biomarkers, Tumor; Brain Neoplasms; Dacarbazine; Disease-Free Survival; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Glioblastoma; Humans; Promoter Regions, Genetic; Sequence Analysis, DNA; Temozolomide; Tumor Suppressor Proteins | 2016 |
Current and Future Drug Treatments for Glioblastomas.
Topics: Angiogenesis Inhibitors; Anticonvulsants; Antineoplastic Agents, Alkylating; Bevacizumab; Brain Neoplasms; Carmustine; Dacarbazine; Glioblastoma; Humans; Immunotherapy; Temozolomide | 2016 |
Glioblastoma Secondary to Meningioma: A Case Report and Literature Review.
Topics: Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Glial Fibrillary Acidic Protein; Glioblastoma; Humans; Ki-67 Antigen; Magnetic Resonance Imaging; Male; Meningeal Neoplasms; Meningioma; Mucin-1; Temozolomide | 2017 |
Radiation Therapy for Glioblastoma: American Society of Clinical Oncology Clinical Practice Guideline Endorsement of the American Society for Radiation Oncology Guideline.
Topics: Antineoplastic Agents, Alkylating; Biopsy; Brain Neoplasms; Chemoradiotherapy; Consensus; Cranial Irradiation; Dacarbazine; Dose Fractionation, Radiation; Evidence-Based Medicine; Glioblastoma; Humans; Patient Selection; Temozolomide; Treatment Outcome | 2017 |
Temozolomide with or without Radiotherapy in Patients with Newly Diagnosed Glioblastoma Multiforme: A Meta-Analysis.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Disease-Free Survival; Female; Glioblastoma; Humans; Male; Middle Aged; Radiotherapy; Temozolomide | 2017 |
Critical review of the addition of tumor treating fields (TTFields) to the existing standard of care for newly diagnosed glioblastoma patients.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Disease-Free Survival; Female; Glioblastoma; Humans; Male; Medical Oncology; Middle Aged; Randomized Controlled Trials as Topic; Standard of Care; Temozolomide | 2017 |
Single vs. combination immunotherapeutic strategies for glioma.
Topics: Animals; Brain Neoplasms; Cancer Vaccines; Combined Modality Therapy; Dacarbazine; Genetic Therapy; Glioma; Humans; Immunotherapy; Temozolomide | 2017 |
Mechanisms of disease: temozolomide and glioblastoma--look to the future.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemotherapy, Adjuvant; Clinical Trials as Topic; Combined Modality Therapy; Dacarbazine; Drug Resistance, Neoplasm; Glioblastoma; Humans; O(6)-Methylguanine-DNA Methyltransferase; Prognosis; Substrate Specificity; Survival Analysis; Temozolomide | 2008 |
New (alternative) temozolomide regimens for the treatment of glioma.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Glioma; Humans; O(6)-Methylguanine-DNA Methyltransferase; Temozolomide | 2009 |
Temozolomide for high grade glioma.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Glioblastoma; Humans; Neoplasm Recurrence, Local; Temozolomide | 2008 |
Multiple intracranial melanoma metastases: case report and review of the literature.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Combined Modality Therapy; Cranial Irradiation; Dacarbazine; Fatal Outcome; Female; Humans; Magnetic Resonance Imaging; Melanoma; Middle Aged; Skin Neoplasms; Temozolomide | 2009 |
[Association of radiotherapy and chemotherapy-targeted therapies in glioblastomas].
Topics: Angiogenesis Inhibitors; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents, Alkylating; Bevacizumab; Brain Neoplasms; Camptothecin; Combined Modality Therapy; Dacarbazine; Glioblastoma; Humans; Irinotecan; Neovascularization, Pathologic; Temozolomide; Vascular Endothelial Growth Factor A | 2009 |
[Predictive molecular pathological testing in the diagnosis of high-grade tumors of glial origin].
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemotherapy, Adjuvant; Chromosomes, Human, Pair 1; Chromosomes, Human, Pair 19; Dacarbazine; DNA Methylation; ErbB Receptors; Gene Amplification; Gene Expression Regulation, Neoplastic; Glioma; Humans; Immunohistochemistry; In Situ Hybridization, Fluorescence; O(6)-Methylguanine-DNA Methyltransferase; Polymerase Chain Reaction; Predictive Value of Tests; Prognosis; Promoter Regions, Genetic; Radiotherapy, Adjuvant; Signal Transduction; Temozolomide; Up-Regulation | 2009 |
Temozolomide with radiation therapy in high grade brain gliomas: pharmaceuticals considerations and efficacy; a review article.
Topics: Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Drug Resistance, Neoplasm; Glioblastoma; Humans; MEDLINE; Molecular Structure; Randomized Controlled Trials as Topic; Temozolomide | 2009 |
[Prescription guidebook for temozolomide usage in brain tumors].
Topics: Age Factors; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Dacarbazine; Drug Administration Schedule; Drug Labeling; Glioblastoma; Glioma; Humans; Temozolomide | 2009 |
Temozolomide in malignant gliomas: current use and future targets.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Drug Resistance, Neoplasm; Glioma; Humans; Temozolomide | 2009 |
[Clinicopathological diagnosis of gliomas by genotype analysis].
Topics: Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Chromosomes, Human, Pair 1; Chromosomes, Human, Pair 19; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; Genotype; Glioblastoma; Humans; Lomustine; Loss of Heterozygosity; Molecular Diagnostic Techniques; Pharmacogenetics; Procarbazine; Prognosis; Temozolomide; Tumor Suppressor Proteins; Vincristine | 2009 |
[Treatment of glioma with temozolomide].
Topics: Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carmustine; Dacarbazine; DNA Damage; Glioblastoma; Humans; Leukemia, Myeloid, Acute; Lomustine; Myelodysplastic Syndromes; Neoplasms, Second Primary; O(6)-Methylguanine-DNA Methyltransferase; Temozolomide | 2009 |
Insights into pharmacotherapy of malignant glioma in adults.
Topics: Adult; Aged; Angiogenesis Inhibitors; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Bevacizumab; Brain Neoplasms; Chemotherapy, Adjuvant; Dacarbazine; Erlotinib Hydrochloride; Glioblastoma; Glioma; Humans; Quinazolines; Temozolomide | 2009 |
Current treatment strategies for brain metastasis and complications from therapeutic techniques: a review of current literature.
Topics: Blood-Brain Barrier; Brain; Brain Neoplasms; Cognition; Dacarbazine; Humans; Neoplasm Metastasis; Prognosis; Radiation-Sensitizing Agents; Radiosurgery; Survival Rate; Temozolomide; Time Factors | 2010 |
Radiotherapy for metastatic brain tumors.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemotherapy, Adjuvant; Cognition Disorders; Cranial Irradiation; Dacarbazine; Dose Fractionation, Radiation; Humans; Patient Selection; Radiation Injuries; Radiosurgery; Radiotherapy, Adjuvant; Temozolomide; Treatment Outcome | 2009 |
Pseudoprogression and pseudoresponse in the treatment of gliomas.
Topics: Antineoplastic Agents; Brain Neoplasms; Dacarbazine; Diagnostic Imaging; Disease Progression; Glioma; Humans; Radionuclide Imaging; Temozolomide; Treatment Outcome | 2009 |
Concomitant or adjuvant temozolomide with whole-brain irradiation for brain metastases: a meta-analysis.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemotherapy, Adjuvant; Dacarbazine; Humans; Temozolomide; Treatment Outcome | 2010 |
Current developments in the radiotherapy approach to elderly and frail patients with glioblastoma multiforme.
Topics: Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemotherapy, Adjuvant; Combined Modality Therapy; Dacarbazine; Frail Elderly; Glioblastoma; Humans; Quality of Life; Radiotherapy Dosage; Temozolomide | 2009 |
Anti-glioma therapy with temozolomide and status of the DNA-repair gene MGMT.
Topics: Animals; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; DNA Repair; Glioblastoma; Humans; O(6)-Methylguanine-DNA Methyltransferase; Temozolomide | 2009 |
Simultaneous integrated boost intensity-modulated radiotherapy in patients with high-grade gliomas.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Dacarbazine; Female; Humans; Male; Middle Aged; Oligodendroglioma; Radiotherapy Dosage; Radiotherapy, Intensity-Modulated; Retrospective Studies; Survival Rate; Temozolomide; Tumor Burden; Young Adult | 2010 |
Should biomarkers be used to design personalized medicine for the treatment of glioblastoma?
Topics: Antineoplastic Agents; Biomarkers, Tumor; Brain Neoplasms; Clinical Trials as Topic; Dacarbazine; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Drug Resistance, Neoplasm; Glioblastoma; Humans; Precision Medicine; Temozolomide; Tumor Suppressor Proteins | 2010 |
Temozolomide: therapeutic limitations in the treatment of adult high-grade gliomas.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemotherapy, Adjuvant; Clinical Trials as Topic; Combined Modality Therapy; Dacarbazine; Drug Resistance, Neoplasm; Female; Glioblastoma; Glioma; Humans; Male; Palliative Care; Recurrence; Temozolomide; Treatment Outcome | 2010 |
Brain metastasis in melanoma: clinical activity of CTLA-4 antibody therapy.
Topics: Antibodies, Monoclonal; Antigens, CD; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; CTLA-4 Antigen; Dacarbazine; Humans; Ipilimumab; Italy; Melanoma; Nitrosourea Compounds; Organophosphorus Compounds; Survival Analysis; Temozolomide; United States | 2010 |
O6-methylguanine DNA methyltransferase gene promoter methylation status in gliomas and its correlation with other molecular alterations: first Indian report with review of challenges for use in customized treatment.
Topics: Adult; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chromosomes, Human, Pair 1; Dacarbazine; Designer Drugs; DNA Methylation; ErbB Receptors; Female; Gene Expression Regulation, Neoplastic; Glioma; Humans; India; Isocitrate Dehydrogenase; Male; Middle Aged; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Promoter Regions, Genetic; Retrospective Studies; Temozolomide; Tumor Suppressor Protein p53; Young Adult | 2010 |
[Drug therapy of patients with recurrent glioblastoma: is there any evidence?].
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Drugs, Investigational; Evidence-Based Medicine; Glioblastoma; Humans; Neoplasm Recurrence, Local; Palliative Care; Retreatment; Survival Rate; Temozolomide | 2011 |
Temozolomide: Expanding its role in brain cancer.
Topics: Aged; Animals; Antineoplastic Agents, Alkylating; Brain Neoplasms; Central Nervous System Neoplasms; Dacarbazine; Drug Resistance, Neoplasm; Glioma; Humans; Temozolomide | 2010 |
[Pseudoprogression or pseudoresponse: a challenge for the diagnostic imaging in Glioblastoma multiforme].
Topics: Angiogenesis Inhibitors; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents, Alkylating; Bevacizumab; Brain; Brain Neoplasms; Combined Modality Therapy; Cranial Irradiation; Dacarbazine; Diagnosis, Differential; Diagnostic Imaging; Diffusion Magnetic Resonance Imaging; Disease Progression; Glioblastoma; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Angiography; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Positron-Emission Tomography; Radiation Injuries; Sensitivity and Specificity; Temozolomide; Tumor Burden | 2011 |
A novel approach to overcome temozolomide resistance in glioma and melanoma: Inactivation of MGMT by gene therapy.
Topics: Animals; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; Drug Resistance, Neoplasm; Gene Silencing; Genetic Therapy; Glioma; Humans; Melanoma; Skin Neoplasms; Temozolomide; Tumor Suppressor Proteins | 2011 |
Bevacizumab as a treatment option for radiation-induced cerebral necrosis.
Topics: Angiogenesis Inhibitors; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents, Alkylating; Astrocytoma; Bevacizumab; Blood-Brain Barrier; Brain; Brain Edema; Brain Neoplasms; Chemotherapy, Adjuvant; Combined Modality Therapy; Dacarbazine; Humans; Male; Necrosis; Neoplasm Recurrence, Local; Neurologic Examination; Radiation Injuries; Radiosurgery; Radiotherapy Dosage; Radiotherapy Planning, Computer-Assisted; Radiotherapy, Adjuvant; Temozolomide; Vascular Endothelial Growth Factor A; Young Adult | 2011 |
The sequential use of carmustine wafers (Gliadel®) and post-operative radiotherapy with concomitant temozolomide followed by adjuvant temozolomide: a clinical review.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carmustine; Chemotherapy, Adjuvant; Dacarbazine; Decanoic Acids; Drug Implants; Glioblastoma; Hematologic Diseases; Humans; Middle Aged; Multicenter Studies as Topic; Polyesters; Postoperative Care; Postoperative Complications; Practice Guidelines as Topic; Randomized Controlled Trials as Topic; Temozolomide; Venous Thromboembolism; Young Adult | 2011 |
An algorithm for chemotherapy treatment of recurrent glioma patients after temozolomide failure in the general oncology setting.
Topics: Algorithms; Angiogenesis Inhibitors; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Clinical Trials, Phase II as Topic; Dacarbazine; Genotype; Glioma; Humans; Molecular Targeted Therapy; Neoplasm Recurrence, Local; Temozolomide; Treatment Failure | 2011 |
[MGMT analysis in gliomas].
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; DNA Repair; Glioma; Humans; Neoplasm Proteins; O(6)-Methylguanine-DNA Methyltransferase; Prognosis; Temozolomide | 2011 |
Combining temozolomide with other antitumor drugs and target-based agents in the treatment of brain metastases: an unending quest or chasing a chimera?
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Blood-Brain Barrier; Brain Neoplasms; Clinical Trials as Topic; Dacarbazine; Drug Delivery Systems; Humans; Mutant Chimeric Proteins; Temozolomide; Treatment Outcome | 2011 |
Using different schedules of Temozolomide to treat low grade gliomas: systematic review of their efficacy and toxicity.
Topics: Adult; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Drug Administration Schedule; Glioma; Humans; Neoplasm Grading; Temozolomide | 2011 |
[Glioblastoma in the elderly].
Topics: Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemoradiotherapy, Adjuvant; Combined Modality Therapy; Dacarbazine; Developed Countries; Glioblastoma; Humans; Temozolomide | 2011 |
Loco-regional treatments in first-diagnosis glioblastoma: literature review on association between Stupp protocol and Gliadel.
Topics: Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carmustine; Combined Modality Therapy; Dacarbazine; Decanoic Acids; Glioblastoma; Humans; Polyesters; Radiotherapy, Adjuvant; Survival Analysis; Temozolomide; Treatment Outcome | 2011 |
Chemoresistance of glioblastoma cancer stem cells--much more complex than expected.
Topics: Animals; Antigens, CD; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; DNA Repair; Drug Resistance, Neoplasm; Glioblastoma; Humans; Neoplastic Stem Cells; Temozolomide | 2011 |
Hypofractionated radiotherapy with or without concurrent temozolomide in elderly patients with glioblastoma multiforme: a review of ten-year single institutional experience.
Topics: Age Factors; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Disease-Free Survival; Dose-Response Relationship, Radiation; Female; Glioblastoma; Humans; Kaplan-Meier Estimate; Longitudinal Studies; Male; Middle Aged; Radiotherapy, Computer-Assisted; Retrospective Studies; Temozolomide; Tomography, X-Ray Computed | 2012 |
Marked response of gliomatosis cerebri to temozolomide and whole brain radiotherapy.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Child; Child, Preschool; Combined Modality Therapy; Dacarbazine; Disease-Free Survival; DNA Methylation; Female; Humans; Kaplan-Meier Estimate; Magnetic Resonance Imaging; Male; Middle Aged; Neoplasms, Neuroepithelial; Temozolomide; Treatment Outcome; Young Adult | 2012 |
Severe sustained cholestatic hepatitis following temozolomide in a patient with glioblastoma multiforme: case study and review of data from the FDA adverse event reporting system.
Topics: Adverse Drug Reaction Reporting Systems; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemical and Drug Induced Liver Injury; Cholestasis; Dacarbazine; Glioblastoma; Hepatitis; Humans; Male; Middle Aged; Prognosis; Temozolomide; United States; United States Food and Drug Administration | 2012 |
The role of Bcl-2 family proteins in therapy responses of malignant astrocytic gliomas: Bcl2L12 and beyond.
Topics: Antineoplastic Agents; Brain Neoplasms; Caspases; Cell Nucleus; Combined Modality Therapy; Dacarbazine; Glioma; Humans; Proto-Oncogene Proteins c-bcl-2; Signal Transduction; Temozolomide; Tumor Suppressor Protein p53 | 2012 |
Temozolomide dosing regimens for glioma patients.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Dose-Response Relationship, Drug; Glioma; Humans; Temozolomide; Time Factors | 2012 |
Temozolomide and other potential agents for the treatment of glioblastoma multiforme.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Glioblastoma; Humans; Temozolomide; Treatment Outcome | 2012 |
Cellular-based immunotherapies for patients with glioblastoma multiforme.
Topics: Aged; Brain Neoplasms; Cancer Vaccines; Cell Extracts; Clinical Trials as Topic; Combined Modality Therapy; Cytokines; Dacarbazine; Dendritic Cells; Glioblastoma; Humans; Immunomodulation; Immunotherapy; Middle Aged; Temozolomide | 2012 |
Cerebral ganglioneuroblastoma of adult onset: two patients and a review of the literature.
Topics: Adult; Age of Onset; Antineoplastic Agents, Alkylating; Brain; Brain Neoplasms; Chemoradiotherapy; Chemotherapy, Adjuvant; Dacarbazine; Female; Ganglioneuroblastoma; Humans; Magnetic Resonance Imaging; Male; Neurosurgical Procedures; Temozolomide; Tomography, X-Ray Computed | 2012 |
Molecular mechanisms of temozolomide resistance in glioblastoma multiforme.
Topics: Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Chemotherapy, Adjuvant; Dacarbazine; DNA Mismatch Repair; DNA Modification Methylases; DNA Repair; DNA Repair Enzymes; Drug Resistance, Neoplasm; Enzyme Inhibitors; Glioblastoma; Humans; Neoplasm Proteins; Neoplastic Stem Cells; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Prodrugs; Radiation-Sensitizing Agents; Temozolomide; Tumor Suppressor Proteins | 2012 |
Recent medical management of glioblastoma.
Topics: Antibodies, Monoclonal; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Clinical Trials as Topic; Combined Modality Therapy; Dacarbazine; Glioblastoma; Humans; Protein Kinase Inhibitors; Temozolomide | 2012 |
The efficacy of temozolomide for recurrent glioblastoma multiforme.
Topics: Administration, Metronomic; Antineoplastic Agents, Alkylating; Brain Neoplasms; Clinical Trials, Phase II as Topic; Dacarbazine; Disease-Free Survival; Dose-Response Relationship, Drug; Glioblastoma; Humans; Secondary Prevention; Survival Rate; Temozolomide | 2013 |
Potential usefulness of radiosensitizers in glioblastoma.
Topics: Angiogenesis Inhibitors; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemotherapy, Adjuvant; Combined Modality Therapy; Dacarbazine; Glioblastoma; Humans; Radiation-Sensitizing Agents; Radiotherapy; Temozolomide | 2012 |
[Brain metastases from breast cancer: prognostic factors and tailored management].
Topics: Age Factors; Aged; Aged, 80 and over; Antineoplastic Agents; Brain Neoplasms; Breast Neoplasms; Dacarbazine; Female; Humans; Prognosis; Radiation-Sensitizing Agents; Randomized Controlled Trials as Topic; Temozolomide | 2013 |
Temozolomide and unusual indications: review of literature.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Humans; Lung Neoplasms; Melanoma; Neoplasms; Neuroendocrine Tumors; Pituitary Neoplasms; Temozolomide | 2013 |
Temozolomide-related idiosyncratic and other uncommon toxicities: a systematic review.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Female; Glioma; Humans; Male; Middle Aged; Risk Factors; Temozolomide; Young Adult | 2012 |
[Therapeutic strategies and systemic treatment of brain melanoma metastases].
Topics: Antibodies, Monoclonal; Antineoplastic Agents; Blood-Brain Barrier; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Humans; Immunotherapy; Indoles; Ipilimumab; Melanoma; Nitrosourea Compounds; Organophosphorus Compounds; Palliative Care; Radiosurgery; Radiotherapy; Skin Neoplasms; Sulfonamides; Temozolomide; Vemurafenib | 2013 |
Chemotherapy in low-grade gliomas.
Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Chemoradiotherapy; Clinical Trials as Topic; Dacarbazine; Glioma; Humans; Lomustine; Procarbazine; Temozolomide; Treatment Outcome; Vincristine | 2012 |
[Use of angioneogenesis inhibitor monoclonal antibody following standard therapy in recurrent or progressive glioblastoma multiforme].
Topics: Angiogenesis Inhibitors; Antibodies, Monoclonal, Humanized; Antineoplastic Agents, Alkylating; Antineoplastic Agents, Phytogenic; Bevacizumab; Brain Neoplasms; Camptothecin; Dacarbazine; Disease Progression; Drug Approval; Europe; Glioblastoma; Humans; Hungary; Irinotecan; Magnetic Resonance Imaging; Off-Label Use; Recurrence; Temozolomide; Treatment Outcome | 2012 |
Integrin inhibitor cilengitide for the treatment of glioblastoma: a brief overview of current clinical results.
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Chemoradiotherapy, Adjuvant; Clinical Trials as Topic; Dacarbazine; Glioblastoma; Humans; Integrins; Mice; Rats; Signal Transduction; Snake Venoms; Temozolomide | 2012 |
Impact of temozolomide on immune response during malignant glioma chemotherapy.
Topics: Animals; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Drug Resistance, Neoplasm; Glioma; Humans; Immunologic Factors; Temozolomide | 2012 |
[Adjuvant radiochemotherapy in the elderly affected by glioblastoma: single-institution experience and literature review].
Topics: Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Biopsy; Brain Neoplasms; Chemoradiotherapy, Adjuvant; Dacarbazine; Female; Glioblastoma; Humans; Male; Radiotherapy, Conformal; Retrospective Studies; Survival Rate; Temozolomide; Treatment Outcome | 2013 |
Recent therapeutic advances and insights of recurrent glioblastoma multiforme.
Topics: Angiogenesis Inhibitors; Antibodies, Monoclonal, Humanized; Antigens, Neoplasm; Antineoplastic Agents; Bevacizumab; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Dideoxynucleosides; Glioblastoma; Humans; Immunotherapy; Interleukin-13 Receptor alpha2 Subunit; Neoplasm Recurrence, Local; Radiosurgery; Reoperation; Temozolomide | 2013 |
Systematic review and meta-analysis of temozolomide in animal models of glioma: was clinical efficacy predicted?
Topics: Animals; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Disease Models, Animal; Glioma; Mice; Rats; Survival Analysis; Temozolomide; Treatment Outcome; Xenograft Model Antitumor Assays | 2013 |
[Whole brain radiation therapy plus temozolomide in the treatment of brain metastases from non small cell lung cancer: a meta-analysis].
Topics: Brain Neoplasms; Carcinoma, Non-Small-Cell Lung; Combined Modality Therapy; Cranial Irradiation; Dacarbazine; Humans; Randomized Controlled Trials as Topic; Temozolomide | 2012 |
Imaging characteristics of an unusual, high-grade angiocentric glioma: a case report and review of the literature.
Topics: Adolescent; Brain Neoplasms; Combined Modality Therapy; Cranial Nerve Diseases; Dacarbazine; Diagnosis, Differential; Ganglioglioma; Ganglioneuroma; Glioma; Humans; Magnetic Resonance Imaging; Male; Neoplasm Grading; Neoplasm Recurrence, Local; Neuroectodermal Tumors, Primitive; Papilledema; Paresis; Temozolomide; Treatment Outcome; Vision, Low | 2012 |
Temozolomide: a novel oral alkylating agent.
Topics: Administration, Oral; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Drug Administration Schedule; Glioma; Melanoma; Temozolomide | 2001 |
The use of temozolomide in recurrent malignant gliomas.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Clinical Trials as Topic; Dacarbazine; Glioma; Humans; Neoplasm Recurrence, Local; Temozolomide | 2002 |
Chemotherapy for the treatment of metastatic brain tumors.
Topics: Antineoplastic Agents; Brain Neoplasms; Carboplatin; Clinical Trials as Topic; Dacarbazine; Humans; Neoplasm Metastasis; Temozolomide | 2002 |
The emerging role of irinotecan (CPT-11) in the treatment of malignant glioma in brain tumors.
Topics: Adult; Animals; Antineoplastic Agents, Alkylating; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Camptothecin; Carmustine; Clinical Trials as Topic; Dacarbazine; Glioma; Humans; Irinotecan; Neoplasm Recurrence, Local; Temozolomide | 2003 |
The role of chemotherapy in brain metastases.
Topics: Anticonvulsants; Antineoplastic Agents; Blood-Brain Barrier; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Drug Interactions; Humans; Randomized Controlled Trials as Topic; Temozolomide | 2003 |
Oligodendroglioma and anaplastic oligodendroglioma: clinical features, treatment, and prognosis.
Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Chemotherapy, Adjuvant; Dacarbazine; Diagnosis, Differential; Humans; Incidence; Lomustine; Oligodendroglioma; Procarbazine; Prognosis; Radiotherapy, Adjuvant; Risk Assessment; Risk Factors; Temozolomide; Tomography, Emission-Computed; Tomography, X-Ray Computed; Vincristine | 2003 |
Temozolomide: realizing the promise and potential.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Central Nervous System Neoplasms; Dacarbazine; Drug Administration Schedule; Drug Resistance, Neoplasm; Glioma; Humans; Temozolomide | 2003 |
Novel chemotherapeutic agents for the treatment of glioblastoma multiforme.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Antineoplastic Agents, Phytogenic; Apoptosis; Brain Neoplasms; Camptothecin; Cell Differentiation; Dacarbazine; Drug Delivery Systems; Enzyme Inhibitors; ErbB Receptors; Glioblastoma; Humans; Irinotecan; Matrix Metalloproteinase Inhibitors; Signal Transduction; Temozolomide | 2003 |
Benefits of adjuvant chemotherapy in high-grade gliomas.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemotherapy, Adjuvant; Dacarbazine; Glioma; Humans; Nitrosourea Compounds; Patient Selection; Survival Rate; Temozolomide | 2003 |
Can chemotherapy replace radiotherapy in low-grade gliomas? Time for randomized studies.
Topics: Adult; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cisplatin; Cyclophosphamide; Dacarbazine; Disease-Free Survival; Female; Glioma; Humans; Middle Aged; Survival Rate; Temozolomide; Vindesine | 2003 |
Should radiotherapy be standard therapy for brain tumors in the elderly? Cons.
Topics: Age Factors; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Glioma; Humans; Middle Aged; Radiotherapy; Radiotherapy Dosage; Survival Rate; Temozolomide | 2003 |
[Therapy of malignant melanoma at the stage of distant metastasis].
Topics: Antineoplastic Agents; Antineoplastic Agents, Alkylating; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Brain Neoplasms; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Dacarbazine; Disease Progression; Humans; Immunotherapy; Interferon-alpha; Interleukin-2; Liver Neoplasms; Lung Neoplasms; Lymphatic Metastasis; Melanoma; Neoplasm Metastasis; Nitrosourea Compounds; Organophosphorus Compounds; Palliative Care; Prognosis; Radiotherapy Dosage; Randomized Controlled Trials as Topic; Skin Neoplasms; Temozolomide; Time Factors; Tomography, X-Ray Computed; Vindesine | 2004 |
Management of brain metastases in patients with melanoma.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Central Nervous System; Chemotherapy, Adjuvant; Dacarbazine; Humans; Immunotherapy; Melanoma; Radiosurgery; Radiotherapy, Adjuvant; Radiotherapy, Computer-Assisted; Survival Rate; Temozolomide | 2004 |
Immediate post-radiotherapy changes in malignant glioma can mimic tumor progression.
Topics: Antineoplastic Combined Chemotherapy Protocols; Artifacts; Astrocytoma; Brain Edema; Brain Neoplasms; Chemotherapy, Adjuvant; Clinical Trials, Phase III as Topic; Cohort Studies; Combined Modality Therapy; Contrast Media; Cranial Irradiation; Dacarbazine; Dexamethasone; Diagnosis, Differential; Disease Progression; Female; Follow-Up Studies; Gadolinium; Glioma; Humans; Lomustine; Magnetic Resonance Imaging; Male; Middle Aged; Patient Selection; Procarbazine; Temozolomide; Vincristine | 2004 |
Salvage therapy for primary CNS lymphoma with a combination of rituximab and temozolomide.
Topics: Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antigens, CD20; Antigens, Neoplasm; Antineoplastic Agents, Alkylating; Brain Neoplasms; Central Nervous System Neoplasms; Cohort Studies; Combined Modality Therapy; Dacarbazine; Disease-Free Survival; Drug Evaluation; Drug Resistance, Neoplasm; Eye Neoplasms; Female; Humans; Immunotherapy; Life Tables; Lymphoma, B-Cell; Male; Methotrexate; Middle Aged; Neoplasm Recurrence, Local; Remission Induction; Retrospective Studies; Rituximab; Salvage Therapy; Survival Analysis; Temozolomide; Treatment Outcome | 2004 |
Management of pilocytic astrocytoma with diffuse leptomeningeal spread: two cases and review of the literature.
Topics: Antineoplastic Agents, Alkylating; Arachnoid Cysts; Astrocytoma; Brain Neoplasms; Child; Child, Preschool; Dacarbazine; Female; Humans; Magnetic Resonance Imaging; Neurosurgery; Radiotherapy; Temozolomide; Treatment Outcome | 2005 |
Neuro-oncology: the growing role of chemotherapy in glioma.
Topics: Antineoplastic Agents; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemotherapy, Adjuvant; Dacarbazine; Drug Resistance, Neoplasm; Gefitinib; Glioblastoma; Glioma; Humans; Meta-Analysis as Topic; Nitrosourea Compounds; Oligodendroglioma; Paraneoplastic Syndromes; Protein Kinase Inhibitors; Quinazolines; Radiotherapy, Adjuvant; Randomized Controlled Trials as Topic; Temozolomide | 2005 |
Research news and notes.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cost-Benefit Analysis; Dacarbazine; Dendritic Cells; Drug Therapy; Humans; Immunotherapy; Radiotherapy; Temozolomide | 2005 |
Response of low-grade oligodendroglial tumors to temozolomide.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Chromosomes, Human, Pair 1; Controlled Clinical Trials as Topic; Dacarbazine; Humans; Loss of Heterozygosity; Oligodendroglioma; Temozolomide; Treatment Outcome | 2004 |
Treatment-related myelodysplastic syndrome after temozolomide for recurrent high-grade glioma.
Topics: Acute Disease; Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Chromosomes, Human, Pair 11; Dacarbazine; Fatal Outcome; Female; Gene Deletion; Humans; Leukemia; Myelodysplastic Syndromes; Neoplasm Recurrence, Local; Temozolomide | 2005 |
Benefit of temozolomide compared to procarbazine in treatment of glioblastoma multiforme at first relapse: effect on neurological functioning, performance status, and health related quality of life.
Topics: Antineoplastic Agents; Antineoplastic Agents, Alkylating; Brain Neoplasms; Clinical Trials as Topic; Cognition Disorders; Dacarbazine; Disease Progression; Endpoint Determination; Glioblastoma; Health Status; Humans; Neuropsychological Tests; Procarbazine; Quality of Life; Survival Analysis; Temozolomide | 2005 |
Adjuvant chemotherapy in the treatment of high grade gliomas.
Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Chemotherapy, Adjuvant; Dacarbazine; Drug Delivery Systems; Drug Implants; Glioma; Humans; Patient Selection; Prognosis; Temozolomide | 2005 |
[Highly quality-controlled radiation therapy].
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Glioblastoma; Humans; Maximum Tolerated Dose; Quality Assurance, Health Care; Quality Control; Radiotherapy Dosage; Radiotherapy Planning, Computer-Assisted; Radiotherapy, Computer-Assisted; Radiotherapy, Conformal; Temozolomide | 2005 |
Optimal role of temozolomide in the treatment of malignant gliomas.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Clinical Trials as Topic; Dacarbazine; Drug Administration Schedule; Drug Therapy, Combination; Glioma; Humans; Temozolomide | 2005 |
[New place of the chemotherapy in gliomas].
Topics: Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Chemotherapy, Adjuvant; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Dacarbazine; Disease Progression; Glioblastoma; Humans; Prognosis; Survival Rate; Temozolomide | 2005 |
[Radiotherapy for glioblastomas: from radiobiology to concomitant chemotherapy].
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemotherapy, Adjuvant; Clinical Trials as Topic; Dacarbazine; Glioblastoma; Humans; Radiotherapy, Adjuvant; Temozolomide | 2005 |
[Role of extracellular matrix degradation enzyme for glioma invasion].
Topics: ADAM Proteins; Brain Neoplasms; Dacarbazine; Drug Design; Enzyme Inhibitors; Extracellular Matrix; Glioma; Humans; Hydroxamic Acids; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Neoplasm Invasiveness; Serine Endopeptidases; Temozolomide; Tetracyclines | 2005 |
[Chemotherapy for gliomas in children].
Topics: Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Child; Child, Preschool; Clinical Trials as Topic; Combined Modality Therapy; Dacarbazine; Glioma; Humans; Infant; Medulloblastoma; Temozolomide | 2005 |
[Treatment of malignant gliomas in the elderly].
Topics: Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Dose Fractionation, Radiation; Glioma; Humans; Neurosurgical Procedures; Prognosis; Radiotherapy, Conformal; Survival Rate; Temozolomide | 2005 |
[Chemotherapy for brain metastases].
Topics: Anticonvulsants; Antineoplastic Combined Chemotherapy Protocols; Blood-Brain Barrier; Brain Neoplasms; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Small Cell; Dacarbazine; Dementia, Vascular; Humans; Lung Neoplasms; Melanoma; Metalloporphyrins; Prednisolone; Radiation-Sensitizing Agents; Radiotherapy, Adjuvant; Temozolomide | 2005 |
[Standards and new developments in the chemotherapy of glioblastomas].
Topics: Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Chemotherapy, Adjuvant; Cytarabine; Dacarbazine; Decanoic Acids; DNA Modification Methylases; Glioblastoma; Humans; Nimustine; Polyesters; Promoter Regions, Genetic; Temozolomide; Teniposide | 2005 |
Treatment of brain metastases: a short review of current therapies and the emerging role of temozolomide.
Topics: Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Humans; Radiosurgery; Radiotherapy; Temozolomide | 2003 |
The role of chemotherapy in the treatment of low-grade glioma. A review of the literature.
Topics: Antineoplastic Agents; Brain Neoplasms; Clinical Trials as Topic; Dacarbazine; Glioma; Humans; Procarbazine; Temozolomide | 2005 |
Treatment of astrocytomas.
Topics: Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Dacarbazine; Drug Therapy; Humans; Radiotherapy; Signal Transduction; Temozolomide | 2005 |
[Concomitant radiotherapy with chemotherapy in patients with glioblastoma].
Topics: Antineoplastic Agents; Brain Neoplasms; Combined Modality Therapy; Cranial Irradiation; Dacarbazine; Drug Resistance, Neoplasm; Glioblastoma; Humans; Radiation Tolerance; Temozolomide | 2005 |
Recent developments in the use of chemotherapy in brain tumours.
Topics: Antineoplastic Agents; Brain Neoplasms; Camptothecin; Dacarbazine; Glioma; Humans; Irinotecan; Temozolomide | 2006 |
[Update on cerebral tumors].
Topics: Antineoplastic Agents; Antineoplastic Agents, Alkylating; Brain Neoplasms; Combined Modality Therapy; Cranial Irradiation; Dacarbazine; Glioma; Humans; Lymphoma; Radiosurgery; Temozolomide | 2006 |
Advances in the treatment of primary brain tumors: dawn of a new era?
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Clinical Trials, Phase III as Topic; Combined Modality Therapy; Dacarbazine; Disease Progression; Female; Humans; Male; Temozolomide | 2006 |
The evolution of chemoradiation for glioblastoma: a modern success story.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemotherapy, Adjuvant; Dacarbazine; Female; Glioblastoma; Humans; Male; Radiotherapy, Adjuvant; Randomized Controlled Trials as Topic; Temozolomide | 2006 |
Temozolomide: a milestone in the pharmacotherapy of brain tumors.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Clinical Trials as Topic; Dacarbazine; Humans; Temozolomide; Time Factors | 2005 |
Role of temozolomide in pediatric brain tumors.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Clinical Trials as Topic; Dacarbazine; Drug Therapy, Combination; Humans; Pediatrics; Temozolomide | 2006 |
Treatment options for glioblastoma.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Clinical Trials as Topic; Cytotoxins; Dacarbazine; Drug Therapy; Glioblastoma; Growth Inhibitors; Humans; International Agencies; Radiotherapy; Temozolomide | 2006 |
Autophagy, the Trojan horse to combat glioblastomas.
Topics: Antineoplastic Agents, Phytogenic; Autophagy; Brain Neoplasms; Cell Movement; Dacarbazine; Drug Resistance, Neoplasm; Glioblastoma; Humans; Protein Kinases; Signal Transduction; Temozolomide; TOR Serine-Threonine Kinases | 2006 |
New trends in the medical management of glioblastoma multiforme: the role of temozolomide chemotherapy.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Clinical Trials as Topic; Dacarbazine; DNA Methylation; Glioblastoma; Humans; Methyltransferases; Neoplasm Recurrence, Local; Patient Selection; Temozolomide; Treatment Outcome | 2006 |
The role of chemotherapy in the treatment of malignant astrocytomas.
Topics: Antineoplastic Agents; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Drug Therapy; Humans; Immunologic Factors; Nitrosourea Compounds; Temozolomide | 2006 |
Radiation therapy in the management of brain metastases from renal cell carcinoma.
Topics: Brain Neoplasms; Carcinoma, Renal Cell; Dacarbazine; Humans; Kidney Neoplasms; Metalloporphyrins; Neoplasm Metastasis; Radiation Oncology; Radiation-Sensitizing Agents; Radiosurgery; Temozolomide | 2006 |
[Glioma].
Topics: Antineoplastic Agents; Antineoplastic Agents, Alkylating; Brain Neoplasms; Clinical Trials as Topic; Combined Modality Therapy; Dacarbazine; Drug Synergism; Genetic Therapy; Glioma; Humans; Interferon-beta; Nimustine; Radiotherapy; Temozolomide | 2006 |
Temozolomide: a milestone in neuro-oncology and beyond?
Topics: Antineoplastic Agents, Alkylating; Base Pair Mismatch; Brain Neoplasms; Clinical Trials, Phase II as Topic; Dacarbazine; Glioma; Humans; Recurrence; Temozolomide | 2006 |
Drug Insight: temozolomide as a treatment for malignant glioma--impact of a recent trial.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Clinical Trials as Topic; Dacarbazine; DNA Modification Methylases; Drug Resistance, Neoplasm; Glioblastoma; Humans; Prognosis; Temozolomide | 2005 |
Chemotherapy for malignant gliomas.
Topics: Administration, Oral; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemotherapy, Adjuvant; Clinical Trials as Topic; Combined Modality Therapy; Dacarbazine; Glioblastoma; Humans; Radiotherapy, Adjuvant; Survival Rate; Temozolomide | 2006 |
Should concomitant and adjuvant treatment with temozolomide be used as standard therapy in patients with anaplastic glioma?
Topics: Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Carcinoma; Chemotherapy, Adjuvant; Clinical Trials as Topic; Combined Modality Therapy; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; Humans; Oligodendroglioma; Salvage Therapy; Temozolomide; Tumor Suppressor Protein p14ARF; Tumor Suppressor Proteins | 2006 |
Glioma therapy in adults.
Topics: Adult; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Glioma; Humans; Neurosurgical Procedures; Radiotherapy; Temozolomide | 2006 |
Oncolytic viruses and DNA-repair machinery: overcoming chemoresistance of gliomas.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; DNA Damage; DNA Repair; Drug Resistance, Neoplasm; Glioma; Herpesviridae; Humans; Oncolytic Virotherapy; Oncolytic Viruses; Temozolomide | 2006 |
Temozolomide in advanced malignant melanoma with small brain metastases: can we withhold cranial irradiation?
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Cranial Irradiation; Dacarbazine; Female; Humans; Male; Melanoma; Middle Aged; Randomized Controlled Trials as Topic; Survival Analysis; Temozolomide; Treatment Outcome | 2007 |
[Molecular pharmacology on DNA methylating agent temozolomide].
Topics: Antineoplastic Agents, Alkylating; Apoptosis; Brain Neoplasms; Cell Division; Dacarbazine; DNA Damage; DNA Methylation; DNA Mismatch Repair; DNA Repair; Glioma; Humans; O(6)-Methylguanine-DNA Methyltransferase; Protein Kinases; Temozolomide; TOR Serine-Threonine Kinases | 2007 |
[Pattern of care of high-grade gliomas].
Topics: Adrenal Cortex Hormones; Adult; Age Factors; Aged; Anticonvulsants; Antineoplastic Agents, Alkylating; Brain; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Epilepsy; Forecasting; Genetic Markers; Glioblastoma; Glioma; Humans; Magnetic Resonance Imaging; Neoplasm Recurrence, Local; Oligodendroglioma; Prognosis; Quality of Life; Radiotherapy Dosage; Randomized Controlled Trials as Topic; Survival Analysis; Temozolomide; Thromboembolism; Time Factors; Tomography, X-Ray Computed | 2006 |
[What type of adjuvant chemotherapy should be proposed for the initial treatment of glioblastoma?].
Topics: Age Factors; Antineoplastic Agents, Alkylating; Biocompatible Materials; Brain Neoplasms; Carmustine; Chemotherapy, Adjuvant; Dacarbazine; Decanoic Acids; Glioblastoma; Humans; Polyesters; Survival Rate; Temozolomide; Tomography, X-Ray Computed | 2007 |
[Glioma therapy up-date].
Topics: Anticoagulants; Anticonvulsants; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Clinical Trials as Topic; Combined Modality Therapy; Cranial Irradiation; Craniotomy; Dacarbazine; DNA Damage; Drug Administration Schedule; Epilepsy; Forecasting; Glioblastoma; Glioma; Humans; Neoplasm Proteins; O(6)-Methylguanine-DNA Methyltransferase; Palliative Care; Prognosis; Promoter Regions, Genetic; Temozolomide; Thrombophilia | 2007 |
Anaplastic astrocytoma in adults.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Clinical Trials as Topic; Clinical Trials, Phase II as Topic; Dacarbazine; Female; Humans; Incidence; Male; Middle Aged; Neoplasm Recurrence, Local; Prognosis; Risk Factors; Survival Analysis; Temozolomide | 2007 |
[Chemotherapy for malignant gliomas].
Topics: Antineoplastic Combined Chemotherapy Protocols; Blood-Brain Barrier; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; DNA Modification Methylases; DNA Repair; DNA Repair Enzymes; Drug Resistance, Neoplasm; Glioma; Humans; Nitroso Compounds; Survival Rate; Temozolomide; Tumor Suppressor Proteins | 2007 |
Prolonged and severe myelosuppression in two patients after low-dose temozolomide treatment- case study and review of literature.
Topics: Antineoplastic Agents, Alkylating; Bone Marrow; Bone Marrow Diseases; Brain Neoplasms; Cranial Irradiation; Dacarbazine; Dose-Response Relationship, Drug; Female; Fever; Glioblastoma; Humans; Middle Aged; Neutropenia; Severity of Illness Index; Temozolomide; Treatment Outcome | 2007 |
The economics of temozolomide in brain cancer.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Combined Modality Therapy; Cost-Benefit Analysis; Dacarbazine; Glioma; Humans; Quality of Life; Randomized Controlled Trials as Topic; Survival Rate; Temozolomide | 2007 |
Potential biochemical therapy of glioma cancer.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Glioma; Humans; Indoles; Models, Biological; Molecular Structure; Potassium Channel Blockers; Potassium Channels, Calcium-Activated; Temozolomide | 2007 |
Molecular targeted therapies and chemotherapy in malignant gliomas.
Topics: Antineoplastic Agents; Brain Neoplasms; Clinical Trials as Topic; Dacarbazine; Disease-Free Survival; Glioma; Humans; Medical Oncology; Models, Biological; Neoplasm Metastasis; Oligodendroglioma; Signal Transduction; Temozolomide; Treatment Outcome | 2007 |
Temozolomide and radiation in low-grade and anaplastic gliomas: temoradiation.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Chromosomes, Human, Pair 1; Chromosomes, Human, Pair 19; Clinical Trials, Phase III as Topic; Combined Modality Therapy; Dacarbazine; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Glioma; Humans; Promoter Regions, Genetic; Temozolomide; Tumor Suppressor Proteins | 2007 |
Diagnosis and treatment of high-grade astrocytoma.
Topics: Antineoplastic Agents; Astrocytoma; Brachytherapy; Brain Neoplasms; Dacarbazine; Diagnosis, Differential; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Neoplasm Staging; Neurosurgical Procedures; Temozolomide | 2007 |
The effectiveness and cost-effectiveness of carmustine implants and temozolomide for the treatment of newly diagnosed high-grade glioma: a systematic review and economic evaluation.
Topics: Age Factors; Aged; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carmustine; Chemotherapy, Adjuvant; Combined Modality Therapy; Cost-Benefit Analysis; Dacarbazine; Disease-Free Survival; Drug Implants; Female; Glioma; Humans; Male; Middle Aged; Models, Econometric; Neoplasm Staging; Quality of Life; Temozolomide | 2007 |
Management of glioblastoma.
Topics: Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carmustine; Combined Modality Therapy; Dacarbazine; Decanoic Acids; Drug Carriers; Genetic Therapy; Glioblastoma; Humans; Immunotherapy; Polyesters; Temozolomide | 2007 |
[Molecular genetic analysis for malignant gliomas: clinical implications and future directions].
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; Genes, Tumor Suppressor; Glioma; Humans; Loss of Heterozygosity; MicroRNAs; Molecular Diagnostic Techniques; Neoplastic Stem Cells; Signal Transduction; Temozolomide; Tumor Suppressor Proteins | 2008 |
Overcoming therapeutic resistance in malignant gliomas: current practices and future directions.
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Clinical Trials as Topic; Combined Modality Therapy; Dacarbazine; Drug Resistance, Neoplasm; Glioma; Humans; Radiation Tolerance; Radiotherapy; Temozolomide | 2008 |
[Recent advances in chemotherapy for malignant gliomas].
Topics: Antineoplastic Agents; Astrocytoma; Brain Neoplasms; Dacarbazine; DNA Repair; Glioma; Humans; Meta-Analysis as Topic; Oligodendroglioma; Randomized Controlled Trials as Topic; Temozolomide | 2008 |
Carmustine wafers: localized delivery of chemotherapeutic agents in CNS malignancies.
Topics: Animals; Antineoplastic Agents, Alkylating; Brain Neoplasms; Carmustine; Chemotherapy, Adjuvant; Dacarbazine; Delayed-Action Preparations; Glioma; Humans; Neoplasm Metastasis; Neoplasm Recurrence, Local; Temozolomide | 2008 |
Combined modality treatment of glioblastoma multiforme: the role of temozolomide.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Glioblastoma; Humans; Prognosis; Temozolomide; Treatment Outcome | 2006 |
[Genetic diagnoses and individualized treatment of gliomas].
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Chromosomes, Human, Pair 1; Chromosomes, Human, Pair 19; Dacarbazine; Gene Deletion; Glioma; Humans; Molecular Diagnostic Techniques; Neurosurgical Procedures; Pharmacogenetics; Reoperation; Temozolomide | 2008 |
Clinical features, mechanisms, and management of pseudoprogression in malignant gliomas.
Topics: Acute Disease; Antineoplastic Agents, Alkylating; Apoptosis; Brain Edema; Brain Neoplasms; Chemotherapy, Adjuvant; Dacarbazine; Diagnosis, Differential; Diagnostic Imaging; Disease Progression; DNA Modification Methylases; DNA Repair Enzymes; Endothelial Cells; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Glioma; Humans; Magnetic Resonance Imaging; Necrosis; Neoplasm Recurrence, Local; Patient Selection; Radiation Injuries; Radiotherapy, Adjuvant; Risk Assessment; Temozolomide; Treatment Outcome; Tumor Suppressor Proteins; Vascular Endothelial Growth Factor A | 2008 |
Current status of clinical trials for glioblastoma.
Topics: Antineoplastic Agents; Antineoplastic Agents, Alkylating; Benzamides; Biocompatible Materials; Brain Neoplasms; Cancer Vaccines; Clinical Trials as Topic; Combined Modality Therapy; Dacarbazine; Decanoic Acids; ErbB Receptors; Erlotinib Hydrochloride; Farnesyltranstransferase; Gefitinib; Glioblastoma; Humans; Imatinib Mesylate; Immunotoxins; Mechanistic Target of Rapamycin Complex 1; Multiprotein Complexes; Piperazines; Polyesters; Protein Kinase Inhibitors; Proteins; Pyrimidines; Quinazolines; Sirolimus; Temozolomide; TOR Serine-Threonine Kinases; Transcription Factors | 2006 |
The therapeutic challenge of gliomas.
Topics: Antineoplastic Agents; Blood-Brain Barrier; Brain Neoplasms; Dacarbazine; Glioma; Humans; Temozolomide | 1993 |
Systemic treatments for advanced cutaneous melanoma.
Topics: Antibodies, Monoclonal; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cisplatin; Dacarbazine; Humans; Immunotherapy, Active; Interferon-alpha; Interleukin-2; Melanoma; Nitrosourea Compounds; Organophosphorus Compounds; Remission Induction; Skin Neoplasms; Survival Rate; Temozolomide | 1995 |
Primary rhabdomyosarcoma of the brain: observations on a case with clinical and radiological evidence of cure.
Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cyclophosphamide; Dacarbazine; Disease-Free Survival; Doxorubicin; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Radiography; Rhabdomyosarcoma; Vincristine | 1998 |
New chemotherapy options for the treatment of malignant gliomas.
Topics: Adult; Antineoplastic Agents; Brain Neoplasms; Camptothecin; Clinical Trials as Topic; Dacarbazine; Enzyme Inhibitors; Glioma; Humans; Irinotecan; Neovascularization, Pathologic; Oligodendroglioma; Protease Inhibitors; Signal Transduction; Temozolomide; Thalidomide | 1999 |
Temozolomide, a novel alkylating agent with activity in the central nervous system, may improve the treatment of advanced metastatic melanoma.
Topics: Administration, Oral; Antineoplastic Agents, Alkylating; Biological Availability; Brain Neoplasms; Dacarbazine; Humans; Melanoma; Skin Neoplasms; Temozolomide | 2000 |
Temozolomide in malignant gliomas.
Topics: Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Clinical Trials as Topic; Dacarbazine; Disease Progression; Glioblastoma; Humans; Quality of Life; Temozolomide | 2000 |
Temozolomide in early stages of newly diagnosed malignant glioma and neoplastic meningitis.
Topics: Animals; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Clinical Trials as Topic; Dacarbazine; Glioma; Humans; Meningitis; Mice; Mice, Nude; Neoplasm Staging; Quality of Life; Temozolomide; Transplantation, Heterologous | 2000 |
Future directions in the treatment of malignant gliomas with temozolomide.
Topics: Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Biological Availability; Bone Marrow Transplantation; Brain Neoplasms; Carmustine; Cisplatin; Combined Modality Therapy; Dacarbazine; Drug Resistance, Neoplasm; Genetic Therapy; Glioblastoma; Humans; Temozolomide; Topotecan | 2000 |
Temozolomide and treatment of malignant glioma.
Topics: Adult; Animals; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Dacarbazine; Glioblastoma; Glioma; Humans; Incidence; Melanoma; Temozolomide | 2000 |
The effectiveness and cost-effectiveness of temozolomide for the treatment of recurrent malignant glioma: a rapid and systematic review.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Cost-Benefit Analysis; Dacarbazine; Evidence-Based Medicine; Glioma; Humans; Recurrence; Temozolomide; Treatment Outcome; United Kingdom | 2001 |
Atypical teratoid/rhabdoid tumors in adult patients: case report and review of the literature.
Topics: Adult; Antineoplastic Agents, Alkylating; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Delivery, Obstetric; Fatal Outcome; Female; Humans; Magnetic Resonance Imaging; Neoplasm Recurrence, Local; Pregnancy; Pregnancy Complications, Neoplastic; Radiosurgery; Radiotherapy; Rhabdoid Tumor; Temozolomide; Teratoma | 2001 |
Temozolomide for treating brain metastases.
Topics: Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Carcinoma, Non-Small-Cell Lung; Chemotherapy, Adjuvant; Clinical Trials as Topic; Dacarbazine; Female; Humans; Lung Neoplasms; Male; Middle Aged; Neoplasm Recurrence, Local; Temozolomide; Whole-Body Irradiation | 2001 |
Primary malignant melanoma of the pharynx.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cisplatin; Combined Modality Therapy; Dacarbazine; Female; Humans; Immunotherapy, Active; Interferon-alpha; Interleukin-2; Lung Neoplasms; Magnetic Resonance Imaging; Melanoma; Pharyngeal Neoplasms | 2001 |
A rapid and systematic review of the effectiveness of temozolomide for the treatment of recurrent malignant glioma.
Topics: Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Clinical Trials as Topic; Dacarbazine; Disease-Free Survival; Evidence-Based Medicine; Glioblastoma; Humans; Neoplasm Recurrence, Local; Survival Rate; Temozolomide; Treatment Outcome | 2002 |
Current and future developments in the use of temozolomide for the treatment of brain tumours.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Drug Resistance, Neoplasm; Glioma; Humans; Neoplasm Recurrence, Local; Temozolomide | 2001 |
Adults with newly diagnosed high-grade gliomas.
Topics: Adult; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Antioxidants; Brain Neoplasms; Chemotherapy, Adjuvant; Combined Modality Therapy; Contraindications; Cranial Irradiation; Craniotomy; Dacarbazine; Disease Progression; Epidemiologic Methods; Glioblastoma; Humans; Isotretinoin; Lomustine; Palliative Care; Procarbazine; Radiosurgery; Radiotherapy, Adjuvant; Radiotherapy, Conformal; Temozolomide; Treatment Outcome; Vincristine | 2001 |
Chemotherapy: the agents in current use.
Topics: Antineoplastic Agents; Brain Neoplasms; Carmustine; Dacarbazine; Drug Therapy, Combination; Glioma; Humans; Lomustine; Medulloblastoma; Methotrexate; Nitrogen Mustard Compounds; Procarbazine; Semustine; Teniposide; Vincristine | 1975 |
Fotemustine: an overview of its clinical activity in disseminated malignant melanoma.
Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Dacarbazine; Humans; Immunologic Factors; Interferon alpha-2; Interferon-alpha; Lung Neoplasms; Melanoma; Nitrosourea Compounds; Organophosphorus Compounds; Recombinant Proteins; Remission Induction; Vindesine | 1992 |
[Brain metastases of malignant melanomas].
Topics: Antineoplastic Agents; Blood-Brain Barrier; Brain Neoplasms; Carmustine; Dacarbazine; Humans; Interleukin-2; Melanoma; Nitrosourea Compounds; Organophosphorus Compounds; Semustine | 1991 |
[An autopsy case of neurocutaneous melanosis associated with intracerebral malignant melanoma].
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Dacarbazine; Humans; Male; Melanoma; Nevus, Pigmented; Nimustine; Nitrosourea Compounds; Skin Neoplasms; Vincristine | 1987 |
446 trial(s) available for dacarbazine and Brain Neoplasms
| Article | Year |
|---|---|
Afatinib and radiotherapy, with or without temozolomide, in patients with newly diagnosed glioblastoma: results of a phase I trial.
Topics: Adult; Afatinib; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Dacarbazine; Glioblastoma; Humans; Temozolomide; Treatment Outcome | 2021 |
Temozolomide and Radiotherapy versus Radiotherapy Alone in Patients with Glioblastoma, IDH-wildtype: Post Hoc Analysis of the EORTC Randomized Phase III CATNON Trial.
Topics: Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Dacarbazine; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Glioblastoma; Humans; Isocitrate Dehydrogenase; Prospective Studies; Temozolomide | 2022 |
Temozolomide Treatment Alters Mismatch Repair and Boosts Mutational Burden in Tumor and Blood of Colorectal Cancer Patients.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Line, Tumor; Colorectal Neoplasms; Dacarbazine; DNA Mismatch Repair; DNA-Binding Proteins; Humans; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Temozolomide | 2022 |
Surgery for glioblastomas in the elderly: an Association des Neuro-oncologues d'Expression Française (ANOCEF) trial.
Topics: Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Glioblastoma; Glioma; Humans; Quality of Life | 2023 |
Preoperative Chemoradiotherapy With Capecitabine With or Without Temozolomide in Patients With Locally Advanced Rectal Cancer: A Prospective, Randomised Phase II Study Stratified by O
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Capecitabine; Chemoradiotherapy; Dacarbazine; DNA; DNA Methylation; DNA Repair Enzymes; Glioblastoma; Humans; Prospective Studies; Rectal Neoplasms; Temozolomide | 2023 |
Trotabresib, an oral potent bromodomain and extraterminal inhibitor, in patients with high-grade gliomas: A phase I, "window-of-opportunity" study.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Glioblastoma; Glioma; Humans; Temozolomide | 2023 |
Patterns, predictors and prognostic relevance of high-grade hematotoxicity after temozolomide or temozolomide-lomustine in the CeTeG/NOA-09 trial.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Female; Glioblastoma; Humans; Lomustine; Prognosis; Temozolomide | 2023 |
Adjuvant Temozolomide Chemotherapy With or Without Interferon Alfa Among Patients With Newly Diagnosed High-grade Gliomas: A Randomized Clinical Trial.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Female; Glioma; Humans; Interferon-alpha; Male; Middle Aged; Temozolomide; Young Adult | 2023 |
Phase I study of chlorogenic acid injection for recurrent high-grade glioma with long-term follow-up.
Topics: Brain Neoplasms; Chlorogenic Acid; Dacarbazine; Follow-Up Studies; Glioma; Humans; Temozolomide | 2023 |
A phase II study of dose-dense temozolomide and lapatinib for recurrent low-grade and anaplastic supratentorial, infratentorial, and spinal cord ependymoma.
Topics: Adolescent; Adult; Brain Neoplasms; Dacarbazine; Disease-Free Survival; Ependymoma; Humans; Lapatinib; Prospective Studies; Spinal Cord Neoplasms; Temozolomide | 2021 |
Phase I Study of Zotiraciclib in Combination with Temozolomide for Patients with Recurrent High-grade Astrocytomas.
Topics: Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Bayes Theorem; Brain Neoplasms; Dacarbazine; Humans; Maximum Tolerated Dose; Temozolomide | 2021 |
Timed sequential therapy of the selective T-type calcium channel blocker mibefradil and temozolomide in patients with recurrent high-grade gliomas.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Calcium Channels, T-Type; Dacarbazine; Female; Follow-Up Studies; Glioma; Humans; Male; Maximum Tolerated Dose; Mibefradil; Middle Aged; Neoplasm Grading; Neoplasm Recurrence, Local; Survival Rate; Temozolomide; Young Adult | 2017 |
Tumor-treating fields plus chemotherapy versus chemotherapy alone for glioblastoma at first recurrence: a post hoc analysis of the EF-14 trial.
Topics: Adult; Aftercare; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Antineoplastic Agents, Immunological; Bevacizumab; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Electric Stimulation Therapy; Female; Glioblastoma; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Neurosurgical Procedures; Radiotherapy; Survival Analysis; Temozolomide; Treatment Outcome; Young Adult | 2017 |
Biological basis and clinical study of glycogen synthase kinase- 3β-targeted therapy by drug repositioning for glioblastoma.
Topics: Aged; Animals; Antineoplastic Agents, Alkylating; Apoptosis; Biomarkers, Tumor; Brain Neoplasms; Cell Proliferation; Dacarbazine; Drug Repositioning; Drug Resistance, Neoplasm; Drug Therapy, Combination; Enzyme Inhibitors; Female; Follow-Up Studies; Gene Expression Regulation, Neoplastic; Glioblastoma; Glycogen Synthase Kinase 3 beta; Humans; Male; Mice; Middle Aged; Neoplasm Staging; Prognosis; Temozolomide; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2017 |
Multicenter phase II study of temozolomide and myeloablative chemotherapy with autologous stem cell transplant for newly diagnosed anaplastic oligodendroglioma.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemoradiotherapy; Dacarbazine; Disease-Free Survival; Female; Humans; Isocitrate Dehydrogenase; Male; Middle Aged; Oligodendroglioma; Stem Cell Transplantation; Temozolomide; Transplantation, Autologous | 2017 |
A phase II trial of arsenic trioxide and temozolomide in combination with radiation therapy for patients with malignant gliomas.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Arsenic Trioxide; Arsenicals; Brain Neoplasms; Chemoradiotherapy; Dacarbazine; Drug Therapy, Combination; Female; Glioma; Humans; Kaplan-Meier Estimate; Magnetic Resonance Imaging; Male; Middle Aged; Oxides; Temozolomide; Treatment Outcome; Young Adult | 2017 |
Phase 1/2 Trial of 5-Fraction Stereotactic Radiosurgery With 5-mm Margins With Concurrent and Adjuvant Temozolomide in Newly Diagnosed Supratentorial Glioblastoma: Health-Related Quality of Life Results.
Topics: Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemoradiotherapy; Chemotherapy, Adjuvant; Communication; Dacarbazine; Disease Progression; Female; Glioblastoma; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Neoplasm Recurrence, Local; Prospective Studies; Quality of Life; Radiation Dose Hypofractionation; Radiosurgery; Surveys and Questionnaires; Survivors; Temozolomide; Treatment Outcome | 2017 |
Report of safety of pulse dosing of lapatinib with temozolomide and radiation therapy for newly-diagnosed glioblastoma in a pilot phase II study.
Topics: Adult; Aged; Antineoplastic Agents; Brain Neoplasms; Chemoradiotherapy; Dacarbazine; Drug Administration Schedule; Female; Glioblastoma; Humans; Karnofsky Performance Status; Lapatinib; Male; Middle Aged; Necrosis; Pilot Projects; Quinazolines; Temozolomide; Thrombocytopenia; Treatment Outcome | 2017 |
Phase II study of bi-weekly temozolomide plus bevacizumab for adult patients with recurrent glioblastoma.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Brain Neoplasms; Dacarbazine; Disease Progression; Disease-Free Survival; Female; Glioblastoma; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Quality of Life; Temozolomide; Time Factors; Treatment Outcome; Young Adult | 2017 |
Rindopepimut with temozolomide for patients with newly diagnosed, EGFRvIII-expressing glioblastoma (ACT IV): a randomised, double-blind, international phase 3 trial.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cancer Vaccines; Dacarbazine; Disease-Free Survival; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; ErbB Receptors; Female; Follow-Up Studies; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Internationality; Kaplan-Meier Estimate; Male; Middle Aged; Patient Selection; Proportional Hazards Models; Survival Analysis; Temozolomide; Time Factors; Treatment Outcome; Vaccines, Subunit; Young Adult | 2017 |
Health-related quality of life, cognitive screening, and functional status in a randomized phase III trial (EF-14) of tumor treating fields with temozolomide compared to temozolomide alone in newly diagnosed glioblastoma.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cognition; Combined Modality Therapy; Cross-Over Studies; Dacarbazine; Electric Stimulation Therapy; Female; Follow-Up Studies; Glioblastoma; Humans; Karnofsky Performance Status; Male; Mental Status and Dementia Tests; Middle Aged; Quality of Life; Survival Analysis; Temozolomide; Treatment Outcome; Young Adult | 2017 |
Hypofractionated radiotherapy with simultaneous integrated boost (SIB) plus temozolomide in good prognosis patients with glioblastoma: a multicenter phase II study by the Brain Study Group of the Italian Association of Radiation Oncology (AIRO).
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Female; Glioblastoma; Humans; Male; Middle Aged; Prognosis; Radiation Dose Hypofractionation; Radiation Oncology; Societies, Medical; Temozolomide | 2018 |
High frequency of brain metastases after adjuvant therapy for high-risk melanoma.
Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cisplatin; Dacarbazine; Disease Progression; Disease-Free Survival; Female; Follow-Up Studies; Humans; Interferon alpha-2; Interferon-alpha; Lymph Nodes; Lymphatic Metastasis; Male; Melanoma; Neoplasm Staging; Recombinant Proteins; Retrospective Studies; Skin Neoplasms; Skin Ulcer; Survival Rate; Vinblastine | 2017 |
Investigating the Effect of Reirradiation or Systemic Therapy in Patients With Glioblastoma After Tumor Progression: A Secondary Analysis of NRG Oncology/Radiation Therapy Oncology Group Trial 0525.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemoradiotherapy; Cranial Irradiation; Dacarbazine; Disease Progression; Female; Glioblastoma; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Neoplasm Recurrence, Local; Proportional Hazards Models; Re-Irradiation; Salvage Therapy; Temozolomide; Time Factors | 2018 |
A randomized phase II study of everolimus in combination with chemoradiation in newly diagnosed glioblastoma: results of NRG Oncology RTOG 0913.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Chemoradiotherapy; Dacarbazine; Everolimus; Female; Follow-Up Studies; Glioblastoma; Humans; Male; Middle Aged; Prognosis; Survival Rate; Temozolomide; Young Adult | 2018 |
Radiotherapy plus temozolomide in elderly patients with glioblastoma: a "real-life" report.
Topics: Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemoradiotherapy; Dacarbazine; Female; Follow-Up Studies; Glioblastoma; Humans; Male; Prognosis; Radiotherapy Dosage; Radiotherapy, Intensity-Modulated; Survival Rate; Temozolomide | 2017 |
Efficacy and safety of temozolomide plus whole-brain radiotherapy in the treatment of intracranial metastases.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain; Brain Neoplasms; Chemoradiotherapy; Cranial Irradiation; Dacarbazine; Disease-Free Survival; Female; Follow-Up Studies; Humans; Kaplan-Meier Estimate; Magnetic Resonance Imaging; Male; Middle Aged; Quality of Life; Temozolomide; Time Factors; Treatment Outcome; Young Adult | 2017 |
The effect of an adenosine A
Topics: Adenosine A2 Receptor Agonists; Administration, Intravenous; Administration, Oral; Adult; Aged; Antineoplastic Agents, Alkylating; Brain; Brain Neoplasms; Dacarbazine; Feasibility Studies; Female; Glioblastoma; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Purines; Pyrazoles; Receptor, Adenosine A2A; Temozolomide | 2018 |
Radiotherapy quality assurance for the RTOG 0834/EORTC 26053-22054/NCIC CTG CEC.1/CATNON intergroup trial "concurrent and adjuvant temozolomide chemotherapy in newly diagnosed non-1p/19q deleted anaplastic glioma": Individual case review analysis.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemotherapy, Adjuvant; Chromosome Deletion; Chromosomes, Human, Pair 1; Chromosomes, Human, Pair 19; Dacarbazine; Glioma; Humans; Prospective Studies; Quality Assurance, Health Care; Radiotherapy Planning, Computer-Assisted; Retrospective Studies; Temozolomide; Tomography, X-Ray Computed | 2018 |
Interim Results of a Phase II Study of Hypofractionated Radiotherapy with Concurrent Temozolomide Followed by Adjuvant Temozolomide in Patients over 70 Years Old with Newly Diagnosed Glioblastoma.
Topics: Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Disease Progression; Disease-Free Survival; Female; Glioblastoma; Humans; Male; Quality of Life; Radiation Dose Hypofractionation; Surveys and Questionnaires; Temozolomide | 2018 |
High-dose fotemustine in temozolomide-pretreated glioblastoma multiforme patients: A phase I/II trial.
Topics: Administration, Intravenous; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Brain Neoplasms; Dacarbazine; Disease-Free Survival; Drug Administration Schedule; Female; Glioblastoma; Humans; Incidence; Male; Middle Aged; Neoplasm Recurrence, Local; Nitrosourea Compounds; Organophosphorus Compounds; Temozolomide; Thrombocytopenia | 2018 |
Baseline T1 hyperintense and diffusion-restricted lesions are not linked to prolonged survival in bevacizumab-treated glioblastoma patients of the GLARIUS trial.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Brain Neoplasms; Camptothecin; Dacarbazine; Female; Follow-Up Studies; Glioblastoma; Humans; Irinotecan; Magnetic Resonance Imaging; Male; Middle Aged; Prognosis; Survival Rate; Temozolomide | 2019 |
Phase I study of hypofractionated intensity modulated radiation therapy with concurrent and adjuvant temozolomide in patients with glioblastoma multiforme.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brachytherapy; Brain Neoplasms; Chemoradiotherapy; Chemotherapy, Adjuvant; Dacarbazine; Dose Fractionation, Radiation; Female; Follow-Up Studies; Glioblastoma; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Staging; Prognosis; Prospective Studies; Radiotherapy Planning, Computer-Assisted; Radiotherapy, Conformal; Radiotherapy, Intensity-Modulated; Survival Rate; Temozolomide; Young Adult | 2013 |
A phase II single-arm study of irinotecan in combination with temozolomide (TEMIRI) in children with newly diagnosed high grade glioma: a joint ITCC and SIOPE-brain tumour study.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Camptothecin; Child; Child, Preschool; Dacarbazine; Female; Glioma; Humans; Irinotecan; Male; Neoplasm Grading; Temozolomide; Treatment Outcome | 2013 |
Secondary hematological malignancies associated with temozolomide in patients with glioma.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Child; Child, Preschool; Dacarbazine; Female; Follow-Up Studies; Glioma; Hematologic Neoplasms; Humans; Infant; Infant, Newborn; Male; Middle Aged; Neoplasm Staging; Neoplasms, Second Primary; Prognosis; Retrospective Studies; Temozolomide; Young Adult | 2013 |
Phase 2 study of dose-intense temozolomide in recurrent glioblastoma.
Topics: Adaptor Proteins, Signal Transducing; Adult; Aged; Antineoplastic Agents, Alkylating; Biomarkers, Tumor; Brain Neoplasms; Dacarbazine; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Glioblastoma; Humans; Immunoenzyme Techniques; Male; Middle Aged; MutL Protein Homolog 1; MutS Homolog 2 Protein; Neoplasm Recurrence, Local; Neoplasm Staging; Nuclear Proteins; Prognosis; Promoter Regions, Genetic; Real-Time Polymerase Chain Reaction; Survival Rate; Temozolomide; Tumor Suppressor Proteins | 2013 |
A pediatric phase 1 trial of vorinostat and temozolomide in relapsed or refractory primary brain or spinal cord tumors: a Children's Oncology Group phase 1 consortium study.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Child; Child, Preschool; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; Dose-Response Relationship, Drug; Female; Histones; Humans; Hydroxamic Acids; Leukocytes, Mononuclear; Male; Maximum Tolerated Dose; Neutropenia; Promoter Regions, Genetic; Recurrence; Spinal Cord Neoplasms; Temozolomide; Thrombocytopenia; Tumor Suppressor Proteins; Vorinostat | 2013 |
Pilot study of vincristine, oral irinotecan, and temozolomide (VOIT regimen) combined with bevacizumab in pediatric patients with recurrent solid tumors or brain tumors.
Topics: Administration, Oral; Adolescent; Adult; Anti-Bacterial Agents; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Brain Neoplasms; Camptothecin; Cefixime; Child; Child, Preschool; Dacarbazine; Female; Humans; Infant; Irinotecan; Male; Neoplasm Recurrence, Local; Pilot Projects; Sarcoma, Ewing; Temozolomide; Vincristine | 2013 |
Phase II trial of upfront bevacizumab and temozolomide for unresectable or multifocal glioblastoma.
Topics: Adult; Aged; Angiogenesis Inhibitors; Antibodies, Monoclonal, Humanized; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Brain; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Female; Glioblastoma; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Radiography; Temozolomide; Treatment Outcome | 2013 |
Health-related quality of life in elderly patients with newly diagnosed glioblastoma treated with short-course radiation therapy plus concomitant and adjuvant temozolomide.
Topics: Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cognition; Combined Modality Therapy; Communication; Dacarbazine; Disease Progression; Fatigue; Female; Glioblastoma; Health Status; Humans; Karnofsky Performance Status; Male; Neuropsychological Tests; Prospective Studies; Quality of Life; Social Participation; Surveys and Questionnaires; Temozolomide | 2013 |
Magnetic resonance spectroscopy as an early indicator of response to anti-angiogenic therapy in patients with recurrent glioblastoma: RTOG 0625/ACRIN 6677.
Topics: Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Bevacizumab; Biomarkers, Tumor; Brain Neoplasms; Camptothecin; Choline; Creatine; Dacarbazine; Feasibility Studies; Follow-Up Studies; Glioblastoma; Humans; Irinotecan; Magnetic Resonance Spectroscopy; Neoplasm Recurrence, Local; Neovascularization, Pathologic; Prognosis; Prospective Studies; Survival Rate; Temozolomide | 2013 |
MGMT promoter methylation status and prognosis of patients with primary or recurrent glioblastoma treated with carmustine wafers.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carmustine; Chemoradiotherapy; Combined Modality Therapy; Dacarbazine; Disease-Free Survival; DNA Methylation; Female; Glioblastoma; Humans; Karnofsky Performance Status; Male; Middle Aged; O(6)-Methylguanine-DNA Methyltransferase; Prognosis; Promoter Regions, Genetic; Retrospective Studies; Survival Analysis; Temozolomide | 2013 |
Phase I study of temozolomide combined with oral etoposide in children with malignant glial tumors.
Topics: Administration, Oral; Adolescent; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Child; Child, Preschool; Dacarbazine; Drug Resistance, Neoplasm; Etoposide; Female; Follow-Up Studies; Glioma; Humans; Male; Maximum Tolerated Dose; Neoplasm Recurrence, Local; Neoplasm Staging; Prognosis; Prospective Studies; Salvage Therapy; Temozolomide | 2013 |
RTOG 0913: a phase 1 study of daily everolimus (RAD001) in combination with radiation therapy and temozolomide in patients with newly diagnosed glioblastoma.
Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Chemotherapy, Adjuvant; Dacarbazine; Dose Fractionation, Radiation; Everolimus; Female; Glioblastoma; Humans; Male; Maximum Tolerated Dose; Middle Aged; Sirolimus; Temozolomide | 2013 |
Prospective evaluation of health-related quality of life in patients with glioblastoma multiforme treated on a phase II trial of hypofractionated IMRT with temozolomide.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cognition; Combined Modality Therapy; Dacarbazine; Female; Glioblastoma; Humans; Karnofsky Performance Status; Male; Middle Aged; Neuropsychological Tests; Prospective Studies; Quality of Life; Radiotherapy, Intensity-Modulated; Temozolomide | 2013 |
Early post-bevacizumab progression on contrast-enhanced MRI as a prognostic marker for overall survival in recurrent glioblastoma: results from the ACRIN 6677/RTOG 0625 Central Reader Study.
Topics: Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Biomarkers, Tumor; Brain Neoplasms; Camptothecin; Contrast Media; Dacarbazine; Female; Follow-Up Studies; Glioblastoma; Humans; Imaging, Three-Dimensional; Irinotecan; Magnetic Resonance Imaging; Male; Middle Aged; Neoplasm Recurrence, Local; Prognosis; Retrospective Studies; Survival Rate; Temozolomide; Young Adult | 2013 |
Continuous tamoxifen and dose-dense temozolomide in recurrent glioblastoma.
Topics: Adult; Aged; Antineoplastic Agents; Brain Neoplasms; Dacarbazine; Disease Progression; Dose-Response Relationship, Drug; Female; Glioblastoma; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Neoplasm Recurrence, Local; O(6)-Methylguanine-DNA Methyltransferase; Tamoxifen; Temozolomide; Treatment Outcome | 2013 |
Sorafenib plus daily low-dose temozolomide for relapsed glioblastoma: a phase II study.
Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Dacarbazine; Disease Progression; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Glioblastoma; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Niacinamide; Phenylurea Compounds; Recurrence; Sorafenib; Survival Analysis; Temozolomide; Time Factors | 2013 |
Temozolomide added to whole brain radiotherapy in patients with multiple brain metastases of non-small-cell lung cancer: a multicentric Austrian phase II study.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Austria; Brain Neoplasms; Carcinoma, Non-Small-Cell Lung; Chemoradiotherapy; Dacarbazine; Feasibility Studies; Female; Humans; Lung Neoplasms; Male; Middle Aged; Radiation Injuries; Temozolomide; Treatment Outcome | 2013 |
Concurrent and adjuvant temozolomide-based chemoradiotherapy schedules for glioblastoma. Hypotheses based on two prospective phase II trials.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemoradiotherapy, Adjuvant; Clinical Trials, Phase II as Topic; Combined Modality Therapy; Dacarbazine; Disease-Free Survival; Glioblastoma; Humans; Italy; Middle Aged; Prevalence; Prospective Studies; Risk Assessment; Survival Rate; Temozolomide; Treatment Outcome; Young Adult | 2013 |
Phase I trial combining temozolomide plus lapatinib for the treatment of brain metastases in patients with HER2-positive metastatic breast cancer: the LAPTEM trial.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Breast Neoplasms; Dacarbazine; Disease-Free Survival; Female; Humans; Lapatinib; Maximum Tolerated Dose; Middle Aged; Quinazolines; Receptor, ErbB-2; Temozolomide; Treatment Outcome | 2013 |
Clinical and Genetic Factors Associated With Severe Hematological Toxicity in Glioblastoma Patients During Radiation Plus Temozolomide Treatment: A Prospective Study.
Topics: Adult; Aged; Anticonvulsants; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemoradiotherapy; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; Female; Glioblastoma; Hematologic Diseases; Humans; Leukocytes, Mononuclear; Male; Middle Aged; Polymorphism, Single Nucleotide; Prospective Studies; Proton Pump Inhibitors; Temozolomide; Tumor Suppressor Proteins | 2015 |
Dose-dense temozolomide for newly diagnosed glioblastoma: a randomized phase III clinical trial.
Topics: Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemoradiotherapy; Dacarbazine; Disease-Free Survival; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Female; Glioblastoma; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Proportional Hazards Models; Temozolomide; Tumor Suppressor Proteins | 2013 |
Net clinical benefit analysis of radiation therapy oncology group 0525: a phase III trial comparing conventional adjuvant temozolomide with dose-intensive temozolomide in patients with newly diagnosed glioblastoma.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemoradiotherapy; Dacarbazine; Disease-Free Survival; Female; Glioblastoma; Humans; Male; Middle Aged; Neuropsychological Tests; Proportional Hazards Models; Quality of Life; Temozolomide; Young Adult | 2013 |
Improved tumor oxygenation and survival in glioblastoma patients who show increased blood perfusion after cediranib and chemoradiation.
Topics: Angiogenesis Inhibitors; Biomarkers, Tumor; Brain Neoplasms; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; Enzyme-Linked Immunosorbent Assay; Glioblastoma; Humans; Magnetic Resonance Imaging; Oxygen; Polymerase Chain Reaction; Prospective Studies; Protein Kinase Inhibitors; Quinazolines; Receptor Protein-Tyrosine Kinases; Statistics, Nonparametric; Temozolomide; Treatment Outcome; Tumor Suppressor Proteins | 2013 |
Gain of function of mutant TP53 in glioblastoma: prognosis and response to temozolomide.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; Female; Follow-Up Studies; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Male; Middle Aged; Mutation; Polymerase Chain Reaction; Prognosis; Retrospective Studies; RNA, Small Interfering; Survival Rate; Temozolomide; Tumor Suppressor Protein p53; Tumor Suppressor Proteins | 2014 |
Low incidence of pseudoprogression by imaging in newly diagnosed glioblastoma patients treated with cediranib in combination with chemoradiation.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Chemoradiotherapy; Dacarbazine; Disease Progression; Female; Glioblastoma; Humans; Incidence; Magnetic Resonance Imaging; Male; Middle Aged; Quinazolines; Temozolomide; Young Adult | 2014 |
Case numbers for a randomized clinical trial of boron neutron capture therapy for Glioblastoma multiforme.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Borohydrides; Boron Compounds; Boron Neutron Capture Therapy; Brain Neoplasms; Chemoradiotherapy; Dacarbazine; Female; Germany; Glioblastoma; Humans; Male; Middle Aged; Phenylalanine; Prevalence; Risk Factors; Survival Rate; Temozolomide; Treatment Outcome | 2014 |
Hypofractionated intensity modulated radiotherapy with temozolomide in newly diagnosed glioblastoma multiforme.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Antineoplastic Protocols; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Disease-Free Survival; Female; Follow-Up Studies; Glioblastoma; Humans; Kaplan-Meier Estimate; Male; Maximum Tolerated Dose; Middle Aged; Radiotherapy, Intensity-Modulated; Temozolomide; Treatment Outcome | 2014 |
Neoadjuvant cisplatin plus temozolomide versus standard treatment in patients with unresectable glioblastoma or anaplastic astrocytoma: a differential effect of MGMT methylation.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Chemotherapy, Adjuvant; Cisplatin; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; Female; Glioblastoma; Humans; Male; Methylation; Middle Aged; Neoadjuvant Therapy; Radiation-Sensitizing Agents; Retrospective Studies; Survival Analysis; Temozolomide; Treatment Outcome; Tumor Suppressor Proteins; Young Adult | 2014 |
Cilengitide treatment of newly diagnosed glioblastoma patients does not alter patterns of progression.
Topics: Adult; Aged; Angiogenesis Inhibitors; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemoradiotherapy; Chemotherapy, Adjuvant; Dacarbazine; Disease Progression; Female; Glioblastoma; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Middle Aged; Neoplasm Recurrence, Local; Snake Venoms; Temozolomide; Treatment Outcome | 2014 |
Neoadjuvant bevacizumab and irinotecan versus bevacizumab and temozolomide followed by concomitant chemoradiotherapy in newly diagnosed glioblastoma multiforme: A randomized phase II study.
Topics: Adult; Aged; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Brain Neoplasms; Camptothecin; Chemoradiotherapy; Dacarbazine; Disease-Free Survival; Female; Glioblastoma; Humans; Irinotecan; Male; Middle Aged; Neoadjuvant Therapy; Temozolomide; Treatment Outcome | 2014 |
Phase 2 trial of hypofractionated high-dose intensity modulated radiation therapy with concurrent and adjuvant temozolomide for newly diagnosed glioblastoma.
Topics: Antineoplastic Agents, Alkylating; Brain; Brain Neoplasms; Cause of Death; Chemotherapy, Adjuvant; Dacarbazine; Disease-Free Survival; Dose Fractionation, Radiation; Drug Administration Schedule; Female; Glioblastoma; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Necrosis; Neoplasm, Residual; Prospective Studies; Radiation Injuries; Radiotherapy, Intensity-Modulated; Temozolomide | 2014 |
Bevacizumab plus radiotherapy-temozolomide for newly diagnosed glioblastoma.
Topics: Adult; Aged; Aged, 80 and over; Angiogenesis Inhibitors; Antibodies, Monoclonal, Humanized; Bevacizumab; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Disease-Free Survival; Double-Blind Method; Female; Glioblastoma; Humans; Induction Chemotherapy; Kaplan-Meier Estimate; Male; Middle Aged; Quality of Life; Temozolomide; Young Adult | 2014 |
A randomized trial of bevacizumab for newly diagnosed glioblastoma.
Topics: Adult; Angiogenesis Inhibitors; Antibodies, Monoclonal, Humanized; Bevacizumab; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Disease-Free Survival; Double-Blind Method; Glioblastoma; Humans; Proportional Hazards Models; Survival Analysis; Temozolomide | 2014 |
Nimotuzumab, a humanized monoclonal antibody specific for the EGFR, in combination with temozolomide and radiation therapy for newly diagnosed glioblastoma multiforme: First results in Chinese patients.
Topics: Adult; Aged; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Asian People; Brain Neoplasms; Chemoradiotherapy; Dacarbazine; Disease-Free Survival; ErbB Receptors; Female; Glioblastoma; Humans; Male; Middle Aged; Temozolomide; Young Adult | 2016 |
A single-institution phase II trial of radiation, temozolomide, erlotinib, and bevacizumab for initial treatment of glioblastoma.
Topics: Adult; Aged; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Brain Neoplasms; Chemoradiotherapy; Combined Modality Therapy; Dacarbazine; Disease-Free Survival; Erlotinib Hydrochloride; Female; Glioblastoma; Humans; Male; Middle Aged; Quinazolines; Temozolomide; Young Adult | 2014 |
Phase II trial of 7 days on/7 days off temozolmide for recurrent high-grade glioma.
Topics: Adult; Aged; Antibodies, Monoclonal, Humanized; Antineoplastic Agents, Alkylating; Bevacizumab; Brain Neoplasms; Dacarbazine; Disease-Free Survival; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Female; Glioma; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Promoter Regions, Genetic; Temozolomide; Treatment Outcome; Tumor Suppressor Proteins | 2014 |
Whole brain reirradiation and concurrent temozolomide in patients with brain metastases.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Breast Neoplasms; Carcinoma; Carcinoma, Non-Small-Cell Lung; Chemoradiotherapy; Cranial Irradiation; Dacarbazine; Disease Progression; Female; Humans; Lung Neoplasms; Male; Middle Aged; Prognosis; Prospective Studies; Retreatment; Retrospective Studies; Temozolomide; Treatment Outcome | 2014 |
Randomized phase II trial of irinotecan and bevacizumab as neo-adjuvant and adjuvant to temozolomide-based chemoradiation compared with temozolomide-chemoradiation for unresectable glioblastoma: final results of the TEMAVIR study from ANOCEF†.
Topics: Adult; Aged; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Brain Neoplasms; Camptothecin; Chemotherapy, Adjuvant; Dacarbazine; Female; Glioblastoma; Humans; Irinotecan; Male; Middle Aged; Temozolomide | 2014 |
Phase I study of sorafenib combined with radiation therapy and temozolomide as first-line treatment of high-grade glioma.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Chemoradiotherapy; Dacarbazine; Disease-Free Survival; Female; Glioblastoma; Humans; Male; Maximum Tolerated Dose; Middle Aged; Niacinamide; Phenylurea Compounds; Sorafenib; Temozolomide; Treatment Outcome | 2014 |
Chemotherapy alleviates subacute recurrent glioma-associated refractory cerebral edema by downregulating vascular endothelial growth factor.
Topics: Adult; Aged; Brain Edema; Brain Neoplasms; Cisplatin; Dacarbazine; Down-Regulation; Female; Glioma; Humans; Leukopenia; Male; Middle Aged; Nimustine; Postoperative Complications; Temozolomide; Thrombocytopenia; Treatment Outcome; Vascular Endothelial Growth Factor A; Young Adult | 2014 |
A phase I trial of veliparib (ABT-888) and temozolomide in children with recurrent CNS tumors: a pediatric brain tumor consortium report.
Topics: Adolescent; Adult; Antineoplastic Agents, Alkylating; Benzimidazoles; Brain Neoplasms; Child; Child, Preschool; Dacarbazine; Female; Humans; Infant; Leukocytes, Mononuclear; Male; Maximum Tolerated Dose; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Temozolomide; Young Adult | 2014 |
Prognostic and predictive markers in recurrent high grade glioma; results from the BR12 randomised trial.
Topics: Antineoplastic Agents; Brain Neoplasms; Chromosomes, Human, Pair 1; Chromosomes, Human, Pair 19; Dacarbazine; Disease-Free Survival; DNA Methylation; DNA Modification Methylases; DNA Mutational Analysis; DNA Repair Enzymes; DNA, Neoplasm; Female; Glioma; Humans; Isocitrate Dehydrogenase; Lomustine; Male; Predictive Value of Tests; Temozolomide; Tumor Suppressor Proteins; Vincristine | 2014 |
Hypofractionated intensity-modulated radiotherapy with temozolomide chemotherapy may alter the patterns of failure in patients with glioblastoma multiforme.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemoradiotherapy; Dacarbazine; Dose Fractionation, Radiation; Female; Glioblastoma; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Radiography; Radiotherapy, Intensity-Modulated; Temozolomide; Treatment Failure; Treatment Outcome | 2014 |
A phase I/II trial of hydroxychloroquine in conjunction with radiation therapy and concurrent and adjuvant temozolomide in patients with newly diagnosed glioblastoma multiforme.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Autophagy; Brain Neoplasms; Chemoradiotherapy; Chemotherapy, Adjuvant; Combined Modality Therapy; Dacarbazine; Demography; Female; Glioblastoma; Humans; Hydroxychloroquine; Male; Middle Aged; Survival Analysis; Temozolomide; Treatment Outcome; Young Adult | 2014 |
Phase I/IIa trial of fractionated radiotherapy, temozolomide, and autologous formalin-fixed tumor vaccine for newly diagnosed glioblastoma.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cancer Vaccines; Combined Modality Therapy; Dacarbazine; Disease-Free Survival; Dose Fractionation, Radiation; Follow-Up Studies; Glioblastoma; Humans; Japan; Male; Middle Aged; Prospective Studies; Radiotherapy; Survival Rate; Temozolomide; Treatment Outcome; Young Adult | 2014 |
Strategies to prevent brain metastasis in high-risk non-small-cell lung cancer: lessons learned from a randomized study of maintenance temozolomide versus observation.
Topics: Aged; Brain; Brain Neoplasms; Carcinoma, Non-Small-Cell Lung; Dacarbazine; Early Termination of Clinical Trials; Female; Humans; Lung Neoplasms; Maintenance Chemotherapy; Male; Middle Aged; Neoplasm Staging; Radiography; Risk; Survival Analysis; Temozolomide | 2014 |
Gene therapy enhances chemotherapy tolerance and efficacy in glioblastoma patients.
Topics: Adult; Bone Marrow; Brain Neoplasms; Carmustine; Combined Modality Therapy; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; Drug Resistance, Neoplasm; Female; Genetic Therapy; Glioblastoma; Guanine; Hematopoietic Stem Cell Transplantation; Humans; Male; Middle Aged; Models, Biological; Prospective Studies; Temozolomide; Tumor Suppressor Proteins | 2014 |
Phase II study of bevacizumab, temozolomide, and hypofractionated stereotactic radiotherapy for newly diagnosed glioblastoma.
Topics: Adolescent; Adult; Aged; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Biopsy; Brain Neoplasms; Chemotherapy, Adjuvant; Combined Modality Therapy; Dacarbazine; Female; Glioblastoma; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Radiosurgery; Temozolomide; Treatment Outcome; Young Adult | 2014 |
Phase I/randomized phase II study of afatinib, an irreversible ErbB family blocker, with or without protracted temozolomide in adults with recurrent glioblastoma.
Topics: Adult; Afatinib; Aged; Antineoplastic Agents; Brain Neoplasms; Dacarbazine; Drug Therapy, Combination; Female; Glioblastoma; Humans; Kaplan-Meier Estimate; Male; Maximum Tolerated Dose; Middle Aged; Quinazolines; Receptor, ErbB-2; Temozolomide; Treatment Outcome | 2015 |
Cilengitide combined with standard treatment for patients with newly diagnosed glioblastoma with methylated MGMT promoter (CENTRIC EORTC 26071-22072 study): a multicentre, randomised, open-label, phase 3 trial.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Confidence Intervals; Dacarbazine; Disease-Free Survival; DNA Modification Methylases; DNA Repair Enzymes; Dose-Response Relationship, Drug; Drug Administration Schedule; Early Detection of Cancer; Female; Follow-Up Studies; Glioblastoma; Humans; Kaplan-Meier Estimate; Male; Maximum Tolerated Dose; Middle Aged; Neoplasm Invasiveness; Neoplasm Staging; Patient Selection; Promoter Regions, Genetic; Proportional Hazards Models; Reference Values; Snake Venoms; Survival Analysis; Temozolomide; Treatment Outcome; Tumor Suppressor Proteins | 2014 |
Randomized phase II adjuvant factorial study of dose-dense temozolomide alone and in combination with isotretinoin, celecoxib, and/or thalidomide for glioblastoma.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Celecoxib; Chemotherapy, Adjuvant; Dacarbazine; Disease-Free Survival; Drug Combinations; Female; Glioblastoma; Humans; Isotretinoin; Kaplan-Meier Estimate; Male; Middle Aged; Pyrazoles; Sulfonamides; Temozolomide; Thalidomide; Young Adult | 2015 |
Phase II randomized study of whole-brain radiation therapy with or without concurrent temozolomide for brain metastases from breast cancer.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Breast Neoplasms; Combined Modality Therapy; Cranial Irradiation; Dacarbazine; Disease-Free Survival; Female; Humans; Middle Aged; Prospective Studies; Temozolomide | 2015 |
Dendritic cell vaccination combined with temozolomide retreatment: results of a phase I trial in patients with recurrent glioblastoma multiforme.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain; Brain Neoplasms; Cancer Vaccines; Combined Modality Therapy; Dacarbazine; Dendritic Cells; Disease-Free Survival; Feasibility Studies; Female; Glioblastoma; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Neoplasm Recurrence, Local; Retreatment; Temozolomide; Treatment Outcome | 2015 |
Phase II trial of hypofractionated intensity-modulated radiation therapy combined with temozolomide and bevacizumab for patients with newly diagnosed glioblastoma.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Brain Neoplasms; Chemoradiotherapy; Chemotherapy, Adjuvant; Dacarbazine; Dose Fractionation, Radiation; Female; Follow-Up Studies; Glioblastoma; Humans; Male; Middle Aged; Neoplasm Staging; Prognosis; Prospective Studies; Radiotherapy, Intensity-Modulated; Survival Rate; Temozolomide | 2015 |
A phase II trial of everolimus, temozolomide, and radiotherapy in patients with newly diagnosed glioblastoma: NCCTG N057K.
Topics: Antineoplastic Agents; Brain Neoplasms; Dacarbazine; Drug Therapy, Combination; Everolimus; Glioblastoma; Humans; Positron-Emission Tomography; Prognosis; Survival Analysis; Temozolomide; TOR Serine-Threonine Kinases; Treatment Outcome | 2015 |
Efficacy and patient-reported outcomes with dose-intense temozolomide in patients with newly diagnosed pure and mixed anaplastic oligodendroglioma: a phase II multicenter study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chromosome Deletion; Chromosomes, Human, Pair 1; Chromosomes, Human, Pair 19; Dacarbazine; Female; Follow-Up Studies; Humans; Male; Middle Aged; Neoplasm Grading; Oligodendroglioma; Patient Outcome Assessment; Prognosis; Quality of Life; Survival Rate; Temozolomide; Young Adult | 2015 |
Bevacizumab in combination with radiotherapy and temozolomide for patients with newly diagnosed glioblastoma multiforme.
Topics: Adult; Aged; Bevacizumab; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Disease-Free Survival; Drug Administration Schedule; Female; Glioblastoma; Humans; Male; Middle Aged; Neoplasm Staging; Temozolomide | 2015 |
A phase II, multicenter trial of rindopepimut (CDX-110) in newly diagnosed glioblastoma: the ACT III study.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Brain Neoplasms; Cancer Vaccines; Chemoradiotherapy, Adjuvant; Dacarbazine; Disease-Free Survival; ErbB Receptors; Female; Glioblastoma; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Temozolomide; Treatment Outcome; Vaccines, Subunit | 2015 |
Dynamic susceptibility contrast MRI measures of relative cerebral blood volume as a prognostic marker for overall survival in recurrent glioblastoma: results from the ACRIN 6677/RTOG 0625 multicenter trial.
Topics: Adult; Aged; Angiogenesis Inhibitors; Antineoplastic Agents, Alkylating; Antineoplastic Agents, Phytogenic; Bevacizumab; Brain Neoplasms; Camptothecin; Cerebral Cortex; Contrast Media; Dacarbazine; Female; Glioblastoma; Humans; Irinotecan; Kaplan-Meier Estimate; Magnetic Resonance Imaging; Male; Middle Aged; Prognosis; Temozolomide; Treatment Outcome; Young Adult | 2015 |
MGMT Promoter Methylation Is a Strong Prognostic Biomarker for Benefit from Dose-Intensified Temozolomide Rechallenge in Progressive Glioblastoma: The DIRECTOR Trial.
Topics: Adult; Antineoplastic Agents, Alkylating; Biomarkers, Tumor; Brain Neoplasms; Dacarbazine; Disease-Free Survival; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Female; Glioblastoma; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Prognosis; Promoter Regions, Genetic; Proportional Hazards Models; Temozolomide; Tumor Suppressor Proteins; Young Adult | 2015 |
Phase 2 study of temozolomide-based chemoradiation therapy for high-risk low-grade gliomas: preliminary results of Radiation Therapy Oncology Group 0424.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemoradiotherapy; Dacarbazine; Disease-Free Survival; Dose Fractionation, Radiation; Female; Glioma; Humans; Male; Middle Aged; Radiotherapy, Conformal; Research Design; Risk Factors; Temozolomide; Young Adult | 2015 |
Variation over time and interdependence between disease progression and death among patients with glioblastoma on RTOG 0525.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Disease Progression; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Glioblastoma; Humans; Proportional Hazards Models; Temozolomide; Tumor Suppressor Proteins | 2015 |
Two cilengitide regimens in combination with standard treatment for patients with newly diagnosed glioblastoma and unmethylated MGMT gene promoter: results of the open-label, controlled, randomized phase II CORE study.
Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Dacarbazine; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Female; Glioblastoma; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Promoter Regions, Genetic; Snake Venoms; Temozolomide; Treatment Outcome; Tumor Suppressor Proteins | 2015 |
Wilms tumor 1 peptide vaccination combined with temozolomide against newly diagnosed glioblastoma: safety and impact on immunological response.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cancer Vaccines; Cohort Studies; Combined Modality Therapy; Dacarbazine; Disease Progression; Female; Glioblastoma; Humans; Male; Middle Aged; Temozolomide; WT1 Proteins | 2015 |
Phase 1/2 trials of Temozolomide, Motexafin Gadolinium, and 60-Gy fractionated radiation for newly diagnosed supratentorial glioblastoma multiforme: final results of RTOG 0513.
Topics: Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Chemoradiotherapy; Dacarbazine; Disease-Free Survival; Dose Fractionation, Radiation; Female; Glioblastoma; Humans; Male; Maximum Tolerated Dose; Metalloporphyrins; Multivariate Analysis; Supratentorial Neoplasms; Temozolomide | 2015 |
Hypofractionated-intensity modulated radiotherapy (hypo-IMRT) and temozolomide (TMZ) with or without bevacizumab (BEV) for newly diagnosed glioblastoma multiforme (GBM): a comparison of two prospective phase II trials.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Brain Neoplasms; Chemoradiotherapy; Chemotherapy, Adjuvant; Dacarbazine; Dose Fractionation, Radiation; Female; Follow-Up Studies; Glioblastoma; Humans; Male; Middle Aged; Neoplasm Staging; Prognosis; Prospective Studies; Radiotherapy, Intensity-Modulated; Survival Rate; Temozolomide | 2015 |
Comparison of radiation regimens in the treatment of Glioblastoma multiforme: results from a single institution.
Topics: Aged; Antineoplastic Agents, Alkylating; Brachytherapy; Brain Neoplasms; Chemoradiotherapy; Dacarbazine; Dose Fractionation, Radiation; Female; Glioblastoma; Humans; Male; Neoplasm Staging; Prognosis; Radiotherapy Planning, Computer-Assisted; Radiotherapy, Intensity-Modulated; Survival Rate; Temozolomide | 2015 |
BCNU wafer placement with temozolomide (TMZ) in the immediate postoperative period after tumor resection followed by radiation therapy with TMZ in patients with newly diagnosed high grade glioma: final results of a prospective, multi-institutional, phase
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carmustine; Combined Modality Therapy; Dacarbazine; Female; Follow-Up Studies; Glioma; Humans; Male; Middle Aged; Neoplasm Grading; Postoperative Period; Prognosis; Prospective Studies; Radiotherapy Dosage; Survival Rate; Temozolomide | 2015 |
Health-Related Quality of Life in a Randomized Phase III Study of Bevacizumab, Temozolomide, and Radiotherapy in Newly Diagnosed Glioblastoma.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Angiogenesis Inhibitors; Antibodies, Monoclonal, Humanized; Antineoplastic Agents, Alkylating; Bevacizumab; Brain Neoplasms; Chemoradiotherapy; Dacarbazine; Disease Progression; Double-Blind Method; Female; Glioblastoma; Humans; Male; Middle Aged; Placebos; Quality of Life; Surveys and Questionnaires; Survival Analysis; Temozolomide | 2015 |
Phase I dose-escalation study of the PI3K/mTOR inhibitor voxtalisib (SAR245409, XL765) plus temozolomide with or without radiotherapy in patients with high-grade glioma.
Topics: Administration, Oral; Adult; Aged; Antineoplastic Agents; Brain Neoplasms; Dacarbazine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Glioma; Humans; Male; Middle Aged; Phosphoinositide-3 Kinase Inhibitors; Quinoxalines; Sulfonamides; Temozolomide; TOR Serine-Threonine Kinases; Treatment Outcome | 2015 |
Phase II Trial of Upfront Bevacizumab, Irinotecan, and Temozolomide for Unresectable Glioblastoma.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Brain Neoplasms; Camptothecin; Dacarbazine; Drug Administration Schedule; Female; Glioblastoma; Humans; Irinotecan; Male; Middle Aged; Temozolomide; Treatment Outcome | 2015 |
A phase II study of feasibility and toxicity of bevacizumab in combination with temozolomide in patients with recurrent glioblastoma.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Brain Neoplasms; Dacarbazine; Feasibility Studies; Female; Follow-Up Studies; Glioblastoma; Hematologic Diseases; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Staging; Prognosis; Survival Rate; Temozolomide | 2015 |
Phase II trial of pre-irradiation and concurrent temozolomide in patients with newly diagnosed anaplastic oligodendrogliomas and mixed anaplastic oligoastrocytomas: long term results of RTOG BR0131.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Female; Humans; Longitudinal Studies; Magnetic Resonance Imaging; Male; Middle Aged; Oligodendroglioma; Radiotherapy; Retrospective Studies; Temozolomide; Tomography, X-Ray Computed; Treatment Outcome; Young Adult | 2015 |
A Phase 2 Study of Concurrent Radiation Therapy, Temozolomide, and the Histone Deacetylase Inhibitor Valproic Acid for Patients With Glioblastoma.
Topics: Adult; Age Factors; Aged; Antineoplastic Agents, Alkylating; Bone Marrow; Brain Neoplasms; Chemoradiotherapy; Chemotherapy, Adjuvant; Dacarbazine; Disease Progression; Disease-Free Survival; Drug Administration Schedule; Female; Glioblastoma; Histone Deacetylase Inhibitors; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Multivariate Analysis; Radiation Tolerance; Radiation-Sensitizing Agents; Temozolomide; Time Factors; Valproic Acid | 2015 |
Randomized phase II study evaluating veliparib (ABT-888) with temozolomide in patients with metastatic melanoma.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Benzimidazoles; Brain Neoplasms; Dacarbazine; Double-Blind Method; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Male; Melanoma; Middle Aged; Neoplasm Metastasis; Neoplasm Staging; Poly(ADP-ribose) Polymerase Inhibitors; Prognosis; Survival Rate; Temozolomide; Young Adult | 2015 |
Standard chemoradiation for glioblastoma results in progressive brain volume loss.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Antineoplastic Protocols; Brain; Brain Neoplasms; Chemoradiotherapy; Cranial Irradiation; Dacarbazine; Diffusion Tensor Imaging; Glioblastoma; Humans; Longitudinal Studies; Magnetic Resonance Imaging; Male; Middle Aged; Temozolomide | 2015 |
Phase I study of iniparib concurrent with monthly or continuous temozolomide dosing schedules in patients with newly diagnosed malignant gliomas.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Benzamides; Brain; Brain Neoplasms; Dacarbazine; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Glioma; Humans; Magnetic Resonance Imaging; Male; Maximum Tolerated Dose; Middle Aged; Poly(ADP-ribose) Polymerase Inhibitors; Temozolomide; Treatment Outcome | 2015 |
Sunitinib Malate plus Lomustine for Patients with Temozolomide-refractory Recurrent Anaplastic or Low-grade Glioma.
Topics: Adult; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Dacarbazine; Drug Resistance, Neoplasm; Female; Follow-Up Studies; Glioma; Humans; Indoles; Lomustine; Male; Middle Aged; Neoplasm Grading; Neoplasm Recurrence, Local; Neoplasm Staging; Prognosis; Pyrroles; Sunitinib; Survival Rate; Temozolomide | 2015 |
The Diagnostic Ability of Follow-Up Imaging Biomarkers after Treatment of Glioblastoma in the Temozolomide Era: Implications from Proton MR Spectroscopy and Apparent Diffusion Coefficient Mapping.
Topics: Biomarkers, Tumor; Brain Neoplasms; Chemoradiotherapy; Dacarbazine; Diffusion Tensor Imaging; Female; Follow-Up Studies; Glioblastoma; Humans; Male; Middle Aged; Molecular Imaging; Neoplasm Recurrence, Local; Outcome Assessment, Health Care; Prognosis; Proton Magnetic Resonance Spectroscopy; Reproducibility of Results; Sensitivity and Specificity; Temozolomide; Treatment Outcome | 2015 |
A phase II study of bevacizumab and erlotinib after radiation and temozolomide in MGMT unmethylated GBM patients.
Topics: Adult; Antineoplastic Agents; Bevacizumab; Brain Neoplasms; Dacarbazine; Disease-Free Survival; DNA Methylation; DNA Modification Methylases; Erlotinib Hydrochloride; Female; Glioblastoma; Humans; Male; Middle Aged; Prognosis; Radiotherapy; Temozolomide; Treatment Outcome; Young Adult | 2016 |
A concurrent ultra-fractionated radiation therapy and temozolomide treatment: A promising therapy for newly diagnosed, inoperable glioblastoma.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemoradiotherapy; Dacarbazine; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Female; France; Glioblastoma; Humans; Male; Middle Aged; Radiotherapy, Intensity-Modulated; Temozolomide; Treatment Outcome; Tumor Burden; Tumor Suppressor Proteins | 2016 |
A randomized phase I/II study of ABT-888 in combination with temozolomide in recurrent temozolomide resistant glioblastoma: an NRG oncology RTOG group study.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Benzimidazoles; Bevacizumab; Brain Neoplasms; Dacarbazine; Disease-Free Survival; Drug Resistance, Neoplasm; Drug Therapy, Combination; Female; Glioblastoma; Humans; Male; Middle Aged; Poly(ADP-ribose) Polymerase Inhibitors; Survival Analysis; Temozolomide; Treatment Outcome; Young Adult | 2016 |
Phase II trial of irinotecan and metronomic temozolomide in patients with recurrent glioblastoma.
Topics: Administration, Metronomic; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Camptothecin; Dacarbazine; Female; Glioblastoma; Humans; Irinotecan; Male; Middle Aged; Neoplasm Recurrence, Local; Temozolomide | 2016 |
Phase 1 dose escalation trial of the safety and pharmacokinetics of cabozantinib concurrent with temozolomide and radiotherapy or temozolomide after radiotherapy in newly diagnosed patients with high-grade gliomas.
Topics: Adult; Aged; Alanine Transaminase; Anilides; Antineoplastic Combined Chemotherapy Protocols; Aspartate Aminotransferases; Astrocytoma; Brain Neoplasms; Chemoradiotherapy; Chemoradiotherapy, Adjuvant; Constipation; Dacarbazine; Diarrhea; Fatigue; Female; Glioblastoma; Humans; Hypertension; L-Lactate Dehydrogenase; Leukopenia; Maintenance Chemotherapy; Male; Maximum Tolerated Dose; Middle Aged; Nausea; Neoplasm Grading; Neurosurgical Procedures; Neutropenia; Pyridines; Temozolomide; Thrombocytopenia; Treatment Outcome | 2016 |
Maintenance Therapy With Tumor-Treating Fields Plus Temozolomide vs Temozolomide Alone for Glioblastoma: A Randomized Clinical Trial.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Canada; Carmustine; Chemoradiotherapy; Combined Modality Therapy; Dacarbazine; Disease Progression; Disease-Free Survival; Early Termination of Clinical Trials; Electric Stimulation Therapy; Europe; Female; Glioblastoma; Humans; Israel; Maintenance Chemotherapy; Male; Middle Aged; Republic of Korea; Temozolomide; United States; Young Adult | 2015 |
[Randomized controlled study of limited margins IMRT and temozolomide chemotherapy in patients with malignant glioma].
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemoradiotherapy; Chemotherapy, Adjuvant; Dacarbazine; Disease Progression; Disease-Free Survival; DNA Modification Methylases; DNA Repair Enzymes; Glioblastoma; Glioma; Humans; Prognosis; Promoter Regions, Genetic; Radiotherapy, Intensity-Modulated; Remission Induction; Survival Rate; Temozolomide; Tumor Suppressor Proteins | 2015 |
Phase I study of temozolomide in combination with thiotepa and carboplatin with autologous hematopoietic cell rescue in patients with malignant brain tumors with minimal residual disease.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Autografts; Brain Neoplasms; Carboplatin; Child; Child, Preschool; Dacarbazine; Disease-Free Survival; Female; Follow-Up Studies; Hematopoietic Stem Cell Transplantation; Humans; Male; Middle Aged; Neoplasm, Residual; Survival Rate; Temozolomide; Thiotepa | 2016 |
The role of temozolomide in the management of patients with newly diagnosed anaplastic astrocytoma: a comparison of survival in the era prior to and following the availability of temozolomide.
Topics: Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Carmustine; Dacarbazine; Female; Follow-Up Studies; Humans; Lomustine; Male; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Staging; Procarbazine; Prognosis; Retrospective Studies; Survival Rate; Temozolomide; Vincristine | 2016 |
Bevacizumab, temozolomide, and radiotherapy for newly diagnosed glioblastoma: comprehensive safety results during and after first-line therapy.
Topics: Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal, Humanized; Bevacizumab; Brain Neoplasms; Chemoradiotherapy; Dacarbazine; Disease Progression; Female; Glioblastoma; Humans; Male; Middle Aged; Temozolomide; Treatment Outcome; Young Adult | 2016 |
Bevacizumab and temozolomide versus temozolomide alone as neoadjuvant treatment in unresected glioblastoma: the GENOM 009 randomized phase II trial.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Brain Neoplasms; Dacarbazine; Female; Follow-Up Studies; Glioblastoma; Humans; Male; Middle Aged; Neoadjuvant Therapy; Neoplasm Staging; Prognosis; Survival Rate; Temozolomide | 2016 |
Phase 2 study of concurrent radiotherapy and temozolomide followed by temozolomide and lomustine in the treatment of children with high-grade glioma: a report of the Children's Oncology Group ACNS0423 study.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Chemoradiotherapy; Child; Child, Preschool; Dacarbazine; Disease-Free Survival; Female; Glioma; Humans; Lomustine; Male; Temozolomide; Young Adult | 2016 |
A phase I dose escalation study using simultaneous integrated-boost IMRT with temozolomide in patients with unifocal glioblastoma.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Female; Glioblastoma; Humans; Male; Maximum Tolerated Dose; Middle Aged; Radiotherapy Dosage; Radiotherapy, Intensity-Modulated; Temozolomide | 2016 |
Phase II Study of Radiotherapy and Temsirolimus versus Radiochemotherapy with Temozolomide in Patients with Newly Diagnosed Glioblastoma without MGMT Promoter Hypermethylation (EORTC 26082).
Topics: Adult; Aged; Brain Neoplasms; Chemoradiotherapy; Dacarbazine; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Female; Glioblastoma; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Promoter Regions, Genetic; Proportional Hazards Models; Sirolimus; Temozolomide; Tumor Suppressor Proteins; Young Adult | 2016 |
Prognostic value of health-related quality of life for death risk stratification in patients with unresectable glioblastoma.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Brain Neoplasms; Camptothecin; Chemoradiotherapy; Chemotherapy, Adjuvant; Dacarbazine; Female; Glioblastoma; Humans; Irinotecan; Kaplan-Meier Estimate; Karnofsky Performance Status; Male; Middle Aged; Prognosis; Psychometrics; Quality of Life; Temozolomide | 2016 |
A phase II trial evaluating the effects and intra-tumoral penetration of bortezomib in patients with recurrent malignant gliomas.
Topics: Adult; Antineoplastic Agents; Bortezomib; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Drug Therapy, Combination; Female; Glioblastoma; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; NF-KappaB Inhibitor alpha; Proteasome Endopeptidase Complex; Temozolomide; Treatment Outcome | 2016 |
Evaluation of pseudoprogression rates and tumor progression patterns in a phase III trial of bevacizumab plus radiotherapy/temozolomide for newly diagnosed glioblastoma.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Brain Neoplasms; Chemoradiotherapy; Dacarbazine; Disease Progression; Disease-Free Survival; Double-Blind Method; Female; Glioblastoma; Humans; Image Interpretation, Computer-Assisted; Kaplan-Meier Estimate; Magnetic Resonance Imaging; Male; Middle Aged; Temozolomide | 2016 |
Chemotherapy for adult low-grade gliomas: clinical outcomes by molecular subtype in a phase II study of adjuvant temozolomide.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemotherapy, Adjuvant; Dacarbazine; Disease Progression; Female; Follow-Up Studies; Glioma; Humans; Isocitrate Dehydrogenase; Male; Middle Aged; Mutation; Neoplasm Grading; Prognosis; Prospective Studies; Survival Rate; Temozolomide; Young Adult | 2017 |
Health-related quality of life in patients with high-risk low-grade glioma (EORTC 22033-26033): a randomised, open-label, phase 3 intergroup study.
Topics: Brain Neoplasms; Dacarbazine; Glioma; Humans; Neoplasm Grading; Prospective Studies; Quality of Life; Temozolomide | 2016 |
Temozolomide chemotherapy versus radiotherapy in high-risk low-grade glioma (EORTC 22033-26033): a randomised, open-label, phase 3 intergroup study.
Topics: Adult; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Glioma; Humans; Isocitrate Dehydrogenase; Male; Middle Aged; Radiotherapy, Conformal; Temozolomide | 2016 |
Phase III randomized trial of autologous cytokine-induced killer cell immunotherapy for newly diagnosed glioblastoma in Korea.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemoradiotherapy; Combined Modality Therapy; Cytokine-Induced Killer Cells; Dacarbazine; Disease-Free Survival; Female; Glioblastoma; Humans; Male; Middle Aged; Republic of Korea; Temozolomide; Transplantation, Autologous; Treatment Outcome; Young Adult | 2017 |
Phase III randomized study of radiation and temozolomide versus radiation and nitrosourea therapy for anaplastic astrocytoma: results of NRG Oncology RTOG 9813.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Astrocytoma; Biomarkers, Tumor; Brain Neoplasms; Chemoradiotherapy; Dacarbazine; Female; Follow-Up Studies; Humans; Male; Middle Aged; Neoplasm Staging; Nitrosourea Compounds; Prognosis; Prospective Studies; Survival Rate; Temozolomide; Young Adult | 2017 |
A Phase 2 Trial of Neoadjuvant Temozolomide Followed by Hypofractionated Accelerated Radiation Therapy With Concurrent and Adjuvant Temozolomide for Patients With Glioblastoma.
Topics: Adult; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemoradiotherapy; Chemotherapy, Adjuvant; Dacarbazine; Disease-Free Survival; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Drug Administration Schedule; Female; Follow-Up Studies; Glioblastoma; Humans; Karnofsky Performance Status; Male; Middle Aged; Neoadjuvant Therapy; Pancytopenia; Prospective Studies; Radiation Dose Hypofractionation; Reoperation; Temozolomide; Time Factors; Treatment Failure; Treatment Outcome; Tumor Suppressor Proteins | 2017 |
Efficacy and safety results of ABT-414 in combination with radiation and temozolomide in newly diagnosed glioblastoma.
Topics: Adult; Aged; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Biomarkers, Tumor; Brain Neoplasms; Dacarbazine; Disease-Free Survival; Drug Therapy, Combination; Female; Glioblastoma; Humans; Immunoconjugates; Male; Maximum Tolerated Dose; Middle Aged; Temozolomide; Treatment Outcome | 2017 |
Molecular-Based Recursive Partitioning Analysis Model for Glioblastoma in the Temozolomide Era: A Correlative Analysis Based on NRG Oncology RTOG 0525.
Topics: Antineoplastic Agents, Alkylating; Biomarkers, Tumor; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; Epidemiologic Methods; Female; Glioblastoma; Humans; Male; Middle Aged; Neoplasm Proteins; Prognosis; Receptor Protein-Tyrosine Kinases; Temozolomide; Tumor Suppressor Proteins | 2017 |
Phase I trial of aflibercept (VEGF trap) with radiation therapy and concomitant and adjuvant temozolomide in patients with high-grade gliomas.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemotherapy, Adjuvant; Combined Modality Therapy; Dacarbazine; Drug Therapy, Combination; Female; Glioma; Humans; Male; Middle Aged; Neuropsychological Tests; Receptors, Vascular Endothelial Growth Factor; Recombinant Fusion Proteins; Temozolomide; Treatment Outcome; Vascular Endothelial Growth Factor A | 2017 |
[Outcomes of application of modern first-line chemotherapy regimens in complex treatment of glioblastoma patients].
Topics: Antineoplastic Agents; Antineoplastic Protocols; Bevacizumab; Brain Neoplasms; Chemoradiotherapy; Dacarbazine; Disease-Free Survival; Drug Administration Schedule; Female; Glioblastoma; Humans; Male; Middle Aged; Temozolomide | 2016 |
Salvage therapy with bendamustine for temozolomide refractory recurrent anaplastic gliomas: a prospective phase II trial.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Bendamustine Hydrochloride; Brain Neoplasms; Dacarbazine; Drug Resistance, Neoplasm; Female; Glioma; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Neoplasm Recurrence, Local; Prospective Studies; Salvage Therapy; Temozolomide; Treatment Outcome | 2017 |
Second-line chemotherapy with fotemustine in temozolomide-pretreated patients with relapsing glioblastoma: a single institution experience.
Topics: Adult; Aged; Brain Neoplasms; Dacarbazine; Female; Glioblastoma; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Nitrosourea Compounds; Organophosphorus Compounds; Prognosis; Prospective Studies; Temozolomide | 2008 |
Concurrent radiotherapy with temozolomide followed by adjuvant temozolomide and cis-retinoic acid in children with diffuse intrinsic pontine glioma.
Topics: Age Factors; Age of Onset; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Chemotherapy, Adjuvant; Child; Child, Preschool; Combined Modality Therapy; Dacarbazine; Disease-Free Survival; Female; Glioma; Humans; Kaplan-Meier Estimate; Male; Pons; Prognosis; Radiotherapy; Temozolomide; Tretinoin | 2008 |
Stem cell-related "self-renewal" signature and high epidermal growth factor receptor expression associated with resistance to concomitant chemoradiotherapy in glioblastoma.
Topics: Adult; Adult Stem Cells; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Drug Resistance, Neoplasm; ErbB Receptors; Gene Expression Profiling; Genes, Homeobox; Glioblastoma; Humans; Middle Aged; Multigene Family; Radiation Tolerance; Temozolomide | 2008 |
When temozolomide alone fails: adding procarbazine in salvage therapy of glioma.
Topics: Adult; Aged; Antineoplastic Agents; Brain Neoplasms; Dacarbazine; Female; Glioma; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Procarbazine; Salvage Therapy; Survival Analysis; Temozolomide | 2008 |
Temozolomide treatment does not affect topiramate and oxcarbazepine plasma concentrations in chronically treated patients with brain tumor-related epilepsy.
Topics: Adult; Anticonvulsants; Antineoplastic Agents, Alkylating; Brain Neoplasms; Carbamazepine; Dacarbazine; Epilepsy; Female; Follow-Up Studies; Fructose; Humans; Male; Middle Aged; Oxcarbazepine; Temozolomide; Topiramate; Young Adult | 2008 |
Invasive tumor cells and prognosis in a selected population of patients with glioblastoma multiforme.
Topics: Aged; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Female; Glioblastoma; Humans; Male; Middle Aged; Neoplasm Invasiveness; Prognosis; Survival Analysis; Temozolomide; Treatment Outcome | 2008 |
Dose-intensity temozolomide after concurrent chemoradiotherapy in operated high-grade gliomas.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Glioma; Humans; Kaplan-Meier Estimate; Magnetic Resonance Imaging; Male; Middle Aged; Retrospective Studies; Temozolomide | 2008 |
Hypofractionated radiotherapy followed by adjuvant chemotherapy with temozolomide in elderly patients with glioblastoma.
Topics: Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemotherapy, Adjuvant; Combined Modality Therapy; Dacarbazine; Disease-Free Survival; Female; Geriatrics; Glioblastoma; Humans; Karnofsky Performance Status; Male; Prospective Studies; Quality of Life; Radiotherapy; Retrospective Studies; Temozolomide; Treatment Outcome | 2009 |
Phase II trial of preirradiation and concurrent temozolomide in patients with newly diagnosed anaplastic oligodendrogliomas and mixed anaplastic oligoastrocytomas: RTOG BR0131.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents, Phytogenic; Astrocytoma; Brain Neoplasms; Chromosome Deletion; Chromosomes, Human, Pair 1; Chromosomes, Human, Pair 19; Combined Modality Therapy; Dacarbazine; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Dose Fractionation, Radiation; Female; Humans; In Situ Hybridization, Fluorescence; Male; Middle Aged; Neoplasm Recurrence, Local; Oligodendroglioma; Prognosis; Promoter Regions, Genetic; Survival Rate; Temozolomide; Treatment Outcome; Tumor Suppressor Proteins; Young Adult | 2009 |
Temozolomide, thalidomide, and whole brain radiation therapy for patients with brain metastasis from metastatic melanoma: a phase II Cytokine Working Group study.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Combined Modality Therapy; Cranial Irradiation; Dacarbazine; Female; Humans; Male; Melanoma; Middle Aged; Temozolomide; Thalidomide | 2008 |
Pediatric phase I and pharmacokinetic study of erlotinib followed by the combination of erlotinib and temozolomide: a Children's Oncology Group Phase I Consortium Study.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Bone Neoplasms; Brain Neoplasms; Child; Child, Preschool; Dacarbazine; Diarrhea; Drug Eruptions; ErbB Receptors; Erlotinib Hydrochloride; Humans; Maximum Tolerated Dose; Neoplasm Recurrence, Local; Neoplasms, Germ Cell and Embryonal; Neuroblastoma; Osteosarcoma; Quinazolines; Rhabdomyosarcoma; Temozolomide | 2008 |
Phase 2 trial of temozolomide using protracted low-dose and whole-brain radiotherapy for nonsmall cell lung cancer and breast cancer patients with brain metastases.
Topics: Aged; Antineoplastic Agents, Alkylating; Bone Marrow; Brain Neoplasms; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Combined Modality Therapy; Cranial Irradiation; Dacarbazine; Female; Humans; Liver Neoplasms; Lung Neoplasms; Male; Middle Aged; Prognosis; Remission Induction; Survival Rate; Temozolomide | 2008 |
Association of 11C-methionine PET uptake with site of failure after concurrent temozolomide and radiation for primary glioblastoma multiforme.
Topics: Adult; Aged; Algorithms; Antineoplastic Agents, Alkylating; Biopsy; Brain; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Disease Progression; Glioblastoma; Humans; Magnetic Resonance Imaging; Methionine; Middle Aged; Positron-Emission Tomography; Prospective Studies; Radiopharmaceuticals; Retreatment; Software; Temozolomide; Treatment Failure; Young Adult | 2009 |
A multicenter phase I trial of interferon-beta and temozolomide combination therapy for high-grade gliomas (INTEGRA Study).
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Follow-Up Studies; Glioma; Humans; Interferon-beta; Magnetic Resonance Imaging; Middle Aged; Neoplasm Staging; Prognosis; Survival Rate; Temozolomide; Treatment Outcome | 2008 |
Phase I study of the combination of docetaxel, temozolomide and cisplatin in patients with metastatic melanoma.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cisplatin; Cohort Studies; Dacarbazine; Docetaxel; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Humans; Male; Maximum Tolerated Dose; Melanoma; Middle Aged; Neoplasm Staging; Neutropenia; Pulmonary Embolism; Skin Neoplasms; Taxoids; Temozolomide; Treatment Outcome | 2009 |
Temozolomide single-agent chemotherapy for newly diagnosed anaplastic oligodendroglioma.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Chromosomes, Human, Pair 1; Chromosomes, Human, Pair 19; Combined Modality Therapy; Dacarbazine; Disease-Free Survival; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Humans; Kaplan-Meier Estimate; Loss of Heterozygosity; Oligodendroglioma; Prognosis; Promoter Regions, Genetic; Temozolomide; Tumor Suppressor Proteins | 2009 |
Randomized study of postoperative radiotherapy and simultaneous temozolomide without adjuvant chemotherapy for glioblastoma.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Blood Cell Count; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Disease-Free Survival; Ethics, Medical; Female; Glioblastoma; Humans; Male; Middle Aged; Patient Compliance; Patient Selection; Quality of Life; Radiotherapy Dosage; Salvage Therapy; Survival Analysis; Temozolomide | 2008 |
Phase II study of erlotinib plus temozolomide during and after radiation therapy in patients with newly diagnosed glioblastoma multiforme or gliosarcoma.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Erlotinib Hydrochloride; Glioblastoma; Gliosarcoma; Humans; Middle Aged; Protein Kinase Inhibitors; Quinazolines; Temozolomide | 2009 |
Phase II study of protracted daily temozolomide for low-grade gliomas in adults.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Disease-Free Survival; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Drug Administration Schedule; Female; Glioma; Humans; Loss of Heterozygosity; Male; Middle Aged; Survival Analysis; Temozolomide; Tumor Suppressor Proteins | 2009 |
Fotemustine as second-line treatment for recurrent or progressive glioblastoma after concomitant and/or adjuvant temozolomide: a phase II trial of Gruppo Italiano Cooperativo di Neuro-Oncologia (GICNO).
Topics: Adult; Aged; Antineoplastic Agents; Brain Neoplasms; Chemotherapy, Adjuvant; Combined Modality Therapy; Dacarbazine; Disease-Free Survival; Female; Glioblastoma; Humans; Male; Middle Aged; Nitrosourea Compounds; Organophosphorus Compounds; Recurrence; Temozolomide | 2009 |
Phase II trial of temozolomide plus o6-benzylguanine in adults with recurrent, temozolomide-resistant malignant glioma.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Dacarbazine; Drug Resistance, Neoplasm; Female; Glioma; Guanine; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Temozolomide | 2009 |
Randomized phase II trial of erlotinib versus temozolomide or carmustine in recurrent glioblastoma: EORTC brain tumor group study 26034.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Brain Neoplasms; Carmustine; Dacarbazine; ErbB Receptors; Erlotinib Hydrochloride; Female; Glioblastoma; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; PTEN Phosphohydrolase; Quinazolines; Temozolomide | 2009 |
Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Disease Progression; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Female; Follow-Up Studies; Glioblastoma; Humans; Male; Middle Aged; Prognosis; Promoter Regions, Genetic; Survival Analysis; Survival Rate; Temozolomide; Tumor Suppressor Proteins | 2009 |
Phase I trial of temozolomide plus O6-benzylguanine 5-day regimen with recurrent malignant glioma.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Dacarbazine; Female; Glioma; Guanine; Humans; Male; Maximum Tolerated Dose; Middle Aged; Neoplasm Recurrence, Local; Temozolomide; Treatment Outcome | 2009 |
Early metabolic responses in temozolomide treated low-grade glioma patients.
Topics: Adult; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Female; Fluorine Radioisotopes; Follow-Up Studies; Glioma; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Positron-Emission Tomography; Predictive Value of Tests; Temozolomide; Time Factors; Tyrosine; Young Adult | 2009 |
Phase 1 trial of temozolomide plus irinotecan plus O6-benzylguanine in adults with recurrent malignant glioma.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Camptothecin; Dacarbazine; Disease-Free Survival; Female; Glioma; Guanine; Humans; Irinotecan; Male; Maximum Tolerated Dose; Middle Aged; Neoplasm Recurrence, Local; Temozolomide | 2009 |
Randomized phase II trial of chemoradiotherapy followed by either dose-dense or metronomic temozolomide for newly diagnosed glioblastoma.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemotherapy, Adjuvant; Dacarbazine; Disease Progression; Drug Administration Schedule; Female; Glioblastoma; Humans; Isotretinoin; Kaplan-Meier Estimate; Magnetic Resonance Imaging; Male; Middle Aged; Prospective Studies; Radiotherapy, Adjuvant; Temozolomide; Treatment Outcome | 2009 |
Phase II trial of temozolomide (TMZ) plus irinotecan (CPT-11) in adults with newly diagnosed glioblastoma multiforme before radiotherapy.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Camptothecin; Combined Modality Therapy; Dacarbazine; Disease-Free Survival; Female; Follow-Up Studies; Glioblastoma; Humans; Irinotecan; Male; Middle Aged; Survival Rate; Temozolomide; Treatment Outcome | 2009 |
Talampanel with standard radiation and temozolomide in patients with newly diagnosed glioblastoma: a multicenter phase II trial.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Benzodiazepines; Brain Neoplasms; Cranial Irradiation; Dacarbazine; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Excitatory Amino Acid Antagonists; Female; Glioblastoma; Humans; Kaplan-Meier Estimate; Karnofsky Performance Status; Male; Middle Aged; Proportional Hazards Models; Radiotherapy, Adjuvant; Receptors, AMPA; Risk Assessment; Temozolomide; Time Factors; Treatment Outcome; Tumor Suppressor Proteins; United States | 2009 |
Clinical outcome of concomitant chemoradiotherapy followed by adjuvant temozolomide therapy for glioblastaomas: single-center experience.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemotherapy, Adjuvant; Cohort Studies; Combined Modality Therapy; Dacarbazine; Disease-Free Survival; Drug Administration Schedule; Female; Glioblastoma; Humans; Korea; Male; Middle Aged; Radiation Dosage; Radiotherapy, Adjuvant; Survival Rate; Temozolomide; Treatment Outcome; Young Adult | 2009 |
Prospective evaluation of radiotherapy with concurrent and adjuvant temozolomide in children with newly diagnosed diffuse intrinsic pontine glioma.
Topics: Adolescent; Antineoplastic Agents, Alkylating; Brain Neoplasms; Child; Child, Preschool; Combined Modality Therapy; Dacarbazine; Disease Progression; Dose Fractionation, Radiation; Drug Administration Schedule; Feasibility Studies; Female; Glioma; Humans; Male; Pons; Prospective Studies; Temozolomide | 2010 |
Extended-schedule dose-dense temozolomide in refractory gliomas.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Drug Administration Schedule; Drug Delivery Systems; Female; Glioma; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Temozolomide; Treatment Outcome; Young Adult | 2010 |
Two phase II trials of temozolomide with interferon-alpha2b (pegylated and non-pegylated) in patients with recurrent glioblastoma multiforme.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Dacarbazine; Disease-Free Survival; Female; Glioblastoma; Humans; Interferon alpha-2; Interferon Type I; Interferon-alpha; Kaplan-Meier Estimate; Karnofsky Performance Status; Male; Middle Aged; Neoplasm Recurrence, Local; Polyethylene Glycols; Recombinant Proteins; Temozolomide; Treatment Outcome; Young Adult | 2009 |
A phase I dose-escalation study (ISIDE-BT-1) of accelerated IMRT with temozolomide in patients with glioblastoma.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Dose Fractionation, Radiation; Drug Administration Schedule; Female; Glioblastoma; Humans; Male; Maximum Tolerated Dose; Middle Aged; Prospective Studies; Radiotherapy, Intensity-Modulated; Temozolomide; Tumor Burden | 2010 |
Imatinib in combination with hydroxyurea versus hydroxyurea alone as oral therapy in patients with progressive pretreated glioblastoma resistant to standard dose temozolomide.
Topics: Adult; Age Factors; Aged; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Benzamides; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Disease-Free Survival; Female; Glioblastoma; Humans; Hydroxyurea; Imatinib Mesylate; Male; Middle Aged; Neoplasm Recurrence, Local; Piperazines; Pyrimidines; Temozolomide; Treatment Outcome; Young Adult | 2010 |
Radiotherapy and concomitant temozolomide during the first and last weeks in high grade gliomas: long-term analysis of a phase II study.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Disease Progression; Disease-Free Survival; Female; Glioblastoma; Humans; Longitudinal Studies; Magnetic Resonance Imaging; Male; Middle Aged; Radiotherapy, Conformal; Temozolomide; Treatment Outcome | 2010 |
Promoter methylation and expression analysis of MGMT in advanced pediatric brain tumors.
Topics: Adolescent; Antineoplastic Agents, Alkylating; Brain Neoplasms; Child; Child, Preschool; Dacarbazine; Disease-Free Survival; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Drug Resistance, Neoplasm; Female; Humans; Immunohistochemistry; Infant; Male; Neoplasm Recurrence, Local; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Temozolomide; Tumor Suppressor Proteins | 2009 |
Dose-dense temozolomide regimen for the treatment of brain metastases from melanoma, breast cancer, or lung cancer not amenable to surgery or radiosurgery: a multicenter phase II study.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Dacarbazine; Drug Resistance, Neoplasm; Female; Humans; Lung Neoplasms; Male; Maximum Tolerated Dose; Melanoma; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Staging; Palliative Care; Prospective Studies; Remission Induction; Salvage Therapy; Survival Rate; Temozolomide; Treatment Outcome | 2010 |
Population-based study of pseudoprogression after chemoradiotherapy in GBM.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cohort Studies; Combined Modality Therapy; Community Health Planning; Dacarbazine; Disease Progression; Female; Glioblastoma; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Radiotherapy, Adjuvant; Retrospective Studies; Survival Analysis; Temozolomide; Time Factors; Treatment Outcome | 2009 |
Chemoradiotherapy of newly diagnosed glioblastoma with intensified temozolomide.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents, Alkylating; Brain Neoplasms; Combined Modality Therapy; Confidence Intervals; Dacarbazine; Disease-Free Survival; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Drug Administration Schedule; Female; Follow-Up Studies; Germany; Glioblastoma; Humans; Indomethacin; Karnofsky Performance Status; Male; Middle Aged; Prospective Studies; Survival Rate; Temozolomide; Tumor Suppressor Proteins | 2010 |
A phase II study of cisplatin and temozolomide in heavily pre-treated patients with temozolomide-refractory high-grade malignant glioma.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cisplatin; Dacarbazine; Drug Resistance, Neoplasm; Female; Glioma; Humans; Male; Middle Aged; Temozolomide; Young Adult | 2009 |
The neuropharmacokinetics of temozolomide in patients with resectable brain tumors: potential implications for the current approach to chemoradiation.
Topics: Administration, Oral; Aged; Antineoplastic Agents, Alkylating; Area Under Curve; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Feasibility Studies; Female; Humans; Male; Microdialysis; Middle Aged; Pilot Projects; Radiotherapy; Tandem Mass Spectrometry; Temozolomide | 2009 |
NOA-04 randomized phase III trial of sequential radiochemotherapy of anaplastic glioma with procarbazine, lomustine, and vincristine or temozolomide.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Chemotherapy, Adjuvant; Dacarbazine; Disease Progression; Disease-Free Survival; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Drug Administration Schedule; Female; Glioma; Humans; Isocitrate Dehydrogenase; Kaplan-Meier Estimate; Lomustine; Male; Middle Aged; Mutation; Procarbazine; Promoter Regions, Genetic; Proportional Hazards Models; Radiotherapy, Adjuvant; Risk Assessment; Risk Factors; Temozolomide; Time Factors; Treatment Failure; Tumor Suppressor Proteins; Vincristine; Young Adult | 2009 |
IDH1 mutations in low-grade astrocytomas predict survival but not response to temozolomide.
Topics: Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Cohort Studies; Dacarbazine; DNA Mutational Analysis; Female; Humans; Isocitrate Dehydrogenase; Male; Mutation; Retrospective Studies; Survival Analysis; Temozolomide; Treatment Outcome | 2009 |
EORTC study 26041-22041: phase I/II study on concomitant and adjuvant temozolomide (TMZ) and radiotherapy (RT) with PTK787/ZK222584 (PTK/ZK) in newly diagnosed glioblastoma.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Chemotherapy, Adjuvant; Dacarbazine; Female; Glioblastoma; Humans; Male; Maximum Tolerated Dose; Middle Aged; Phthalazines; Pyridines; Radiotherapy, Adjuvant; Temozolomide; Treatment Outcome | 2010 |
Phase II trial of erlotinib with temozolomide and radiation in patients with newly diagnosed glioblastoma multiforme.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Dacarbazine; Disease-Free Survival; DNA Modification Methylases; DNA Repair Enzymes; Erlotinib Hydrochloride; Female; Glioblastoma; Humans; Karnofsky Performance Status; Magnetic Resonance Imaging; Male; Methylation; Middle Aged; Protein Kinase Inhibitors; Quinazolines; Radiotherapy; Temozolomide; Tumor Suppressor Proteins; Young Adult | 2010 |
[A multicenter randomized controlled study of temozolomide in 97 patients with malignant brain glioma].
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Double-Blind Method; Female; Glioma; Humans; Male; Middle Aged; Temozolomide; Young Adult | 2009 |
Intra-arterial chemotherapy with osmotic blood-brain barrier disruption for aggressive oligodendroglial tumors: results of a phase I study.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Blood-Brain Barrier; Brain Neoplasms; Carboplatin; Cross-Linking Reagents; Dacarbazine; Disease-Free Survival; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Humans; Injections, Intra-Arterial; Lomustine; Male; Melphalan; Middle Aged; Oligodendroglioma; Osmotic Pressure; Procarbazine; Temozolomide; Vincristine; Young Adult | 2010 |
Phase I study of vandetanib with radiotherapy and temozolomide for newly diagnosed glioblastoma.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Diverticulitis; Drug Administration Schedule; ErbB Receptors; Female; Gastrointestinal Hemorrhage; Glioblastoma; Humans; Male; Maximum Tolerated Dose; Middle Aged; Neutropenia; Piperidines; Quinazolines; Temozolomide; Thrombocytopenia; Vascular Endothelial Growth Factor Receptor-2 | 2010 |
Enzastaurin plus temozolomide with radiation therapy in glioblastoma multiforme: a phase I study.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cohort Studies; Combined Modality Therapy; Dacarbazine; Female; Glioblastoma; Humans; Indoles; Male; Middle Aged; Temozolomide; Young Adult | 2010 |
Six-month progression-free survival as an alternative primary efficacy endpoint to overall survival in newly diagnosed glioblastoma patients receiving temozolomide.
Topics: Adult; Aged; Antineoplastic Agents; Brain Neoplasms; Dacarbazine; Disease-Free Survival; Female; Glioblastoma; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Temozolomide; Treatment Outcome; Young Adult | 2010 |
Phase II trial of low-dose continuous (metronomic) treatment of temozolomide for recurrent glioblastoma.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Disease-Free Survival; Female; Glioblastoma; Humans; Kaplan-Meier Estimate; Middle Aged; Neoplasm Recurrence, Local; Polymerase Chain Reaction; Quality of Life; Temozolomide; Young Adult | 2010 |
A phase 1 trial of ABT-510 concurrent with standard chemoradiation for patients with newly diagnosed glioblastoma.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Disease Progression; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Fibroblast Growth Factor 1; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Kaplan-Meier Estimate; Magnetic Resonance Imaging; Male; Middle Aged; Oligopeptides; Receptor, TIE-1; Reverse Transcriptase Polymerase Chain Reaction; Temozolomide; Treatment Outcome | 2010 |
Phase II trial of continuous dose-intense temozolomide in recurrent malignant glioma: RESCUE study.
Topics: Adult; Antineoplastic Agents, Alkylating; Brain Neoplasms; Canada; Chemotherapy, Adjuvant; Dacarbazine; Disease Progression; Disease-Free Survival; Female; Glioblastoma; Glioma; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Prospective Studies; Radiotherapy, Adjuvant; Recurrence; Temozolomide; Time Factors; Treatment Outcome | 2010 |
A Phase II study of anti-epidermal growth factor receptor radioimmunotherapy in the treatment of glioblastoma multiforme.
Topics: Adult; Aged; Antibodies, Monoclonal; Antineoplastic Agents, Alkylating; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; ErbB Receptors; Female; Glioblastoma; Humans; Iodine Radioisotopes; Kaplan-Meier Estimate; Male; Middle Aged; Multivariate Analysis; Proportional Hazards Models; Prospective Studies; Radioimmunotherapy; Radiotherapy, Adjuvant; Temozolomide; Young Adult | 2010 |
Effects of concomitant temozolomide and radiation therapies on WT1-specific T-cells in malignant glioma.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cancer Vaccines; Combined Modality Therapy; Dacarbazine; Female; Glioma; Humans; Japan; Killer Cells, Natural; Lymphocyte Count; Male; Middle Aged; Natural Killer T-Cells; Radiotherapy, Conformal; T-Lymphocyte Subsets; T-Lymphocytes, Cytotoxic; T-Lymphocytes, Regulatory; Temozolomide; WT1 Proteins | 2010 |
A phase II trial of primary temozolomide in patients with grade III oligodendroglial brain tumors.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Brain Neoplasms; Chromosomes, Human, Pair 1; Chromosomes, Human, Pair 19; Dacarbazine; Disease-Free Survival; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Female; Gene Deletion; Humans; Kaplan-Meier Estimate; Loss of Heterozygosity; Male; Middle Aged; Oligodendroglioma; Temozolomide; Tumor Suppressor Proteins; Young Adult | 2010 |
Cetuximab, bevacizumab, and irinotecan for patients with primary glioblastoma and progression after radiation therapy and temozolomide: a phase II trial.
Topics: Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Brain Neoplasms; Camptothecin; Cetuximab; Combined Modality Therapy; Dacarbazine; Disease-Free Survival; Female; Glioblastoma; Humans; Immunohistochemistry; Irinotecan; Kaplan-Meier Estimate; Male; Middle Aged; Neoplasm Recurrence, Local; Salvage Therapy; Temozolomide; Young Adult | 2010 |
Phase I/II dose escalation trial of concurrent temozolomide and whole brain radiation therapy for multiple brain metastasis.
Topics: Aged; Aged, 80 and over; Antineoplastic Agents; Brain Neoplasms; Combined Modality Therapy; Cranial Irradiation; Dacarbazine; Disease-Free Survival; Female; Humans; Kaplan-Meier Estimate; Male; Maximum Tolerated Dose; Middle Aged; Temozolomide | 2010 |
Whole-brain radiation therapy plus concomitant temozolomide for the treatment of brain metastases from non-small-cell lung cancer: a randomized, open-label phase II study.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Carcinoma, Non-Small-Cell Lung; Combined Modality Therapy; Cranial Irradiation; Dacarbazine; Female; Humans; Kaplan-Meier Estimate; Lung Neoplasms; Male; Middle Aged; Temozolomide; Treatment Outcome | 2010 |
Phase I/IIa study of cilengitide and temozolomide with concomitant radiotherapy followed by cilengitide and temozolomide maintenance therapy in patients with newly diagnosed glioblastoma.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Biopsy, Needle; Brain Neoplasms; Combined Modality Therapy; Confidence Intervals; Dacarbazine; Disease-Free Survival; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Follow-Up Studies; Glioblastoma; Humans; Immunohistochemistry; Infusions, Intravenous; Kaplan-Meier Estimate; Male; Maximum Tolerated Dose; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Staging; Neurosurgical Procedures; Probability; Radiotherapy, Adjuvant; Radiotherapy, Conformal; Risk Assessment; Snake Venoms; Survival Analysis; Temozolomide; Treatment Outcome | 2010 |
Effect of CYP3A-inducing anti-epileptics on sorafenib exposure: results of a phase II study of sorafenib plus daily temozolomide in adults with recurrent glioblastoma.
Topics: Adult; Aged; Anticonvulsants; Antineoplastic Combined Chemotherapy Protocols; Benzenesulfonates; Brain Neoplasms; Cytochrome P-450 CYP3A; Dacarbazine; Disease-Free Survival; Female; Glioblastoma; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Neoplasm Recurrence, Local; Niacinamide; Phenylurea Compounds; Pyridines; Recurrence; Sorafenib; Temozolomide | 2011 |
Concurrent radiotherapy and temozolomide followed by temozolomide and sorafenib in the first-line treatment of patients with glioblastoma multiforme.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Benzenesulfonates; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Female; Glioblastoma; Humans; Male; Middle Aged; Niacinamide; Phenylurea Compounds; Pyridines; Sorafenib; Temozolomide | 2010 |
A multi-institution phase II study of poly-ICLC and radiotherapy with concurrent and adjuvant temozolomide in adults with newly diagnosed glioblastoma.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carboxymethylcellulose Sodium; Chemotherapy, Adjuvant; Combined Modality Therapy; Dacarbazine; Female; Glioblastoma; Humans; Interferon Inducers; Kaplan-Meier Estimate; Male; Middle Aged; Poly I-C; Polylysine; Radiotherapy; Temozolomide; Young Adult | 2010 |
A new schedule of fotemustine in temozolomide-pretreated patients with relapsing glioblastoma.
Topics: Adult; Aged; Antineoplastic Agents; Brain Neoplasms; Confidence Intervals; Dacarbazine; Disease-Free Survival; Drug Administration Schedule; Female; Follow-Up Studies; Glioblastoma; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Neoplasm Recurrence, Local; Nitrosourea Compounds; Odds Ratio; Organophosphorus Compounds; Temozolomide; Time Factors; Tomography, X-Ray Computed | 2011 |
Impact of adjuvant chemotherapy for gliomatosis cerebri.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carmustine; Chemotherapy, Adjuvant; Child; Cohort Studies; Combined Modality Therapy; Cranial Irradiation; Dacarbazine; Female; Humans; Lomustine; Male; Middle Aged; Neoplasm Staging; Neoplasms, Neuroepithelial; Neoplasms, Radiation-Induced; Procarbazine; Prognosis; Retrospective Studies; Survival Rate; Temozolomide; Vincristine; Young Adult | 2010 |
Randomized phase II study evaluating a carbon ion boost applied after combined radiochemotherapy with temozolomide versus a proton boost after radiochemotherapy with temozolomide in patients with primary glioblastoma: the CLEOPATRA trial.
Topics: Adolescent; Antineoplastic Agents, Alkylating; Brain Neoplasms; Carbon; Combined Modality Therapy; Dacarbazine; Female; Glioblastoma; Humans; Male; Prognosis; Proton Therapy; Radiotherapy Dosage; Relative Biological Effectiveness; Survival Rate; Temozolomide | 2010 |
Phase I trial with biomarker studies of vatalanib (PTK787) in patients with newly diagnosed glioblastoma treated with enzyme inducing anti-epileptic drugs and standard radiation and temozolomide.
Topics: Adult; Aged; Anticonvulsants; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Female; Glioblastoma; Humans; Male; Maximum Tolerated Dose; Membrane Proteins; Middle Aged; Phthalazines; Polymorphism, Single Nucleotide; Pyridines; Radiotherapy; Receptor, TIE-2; Temozolomide; Vascular Endothelial Growth Factor Receptor-1; Vascular Endothelial Growth Factor Receptor-2 | 2011 |
Phase II study of metronomic chemotherapy with bevacizumab for recurrent glioblastoma after progression on bevacizumab therapy.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Brain Neoplasms; Dacarbazine; Disease-Free Survival; Etoposide; Female; Glioblastoma; Humans; Kaplan-Meier Estimate; Karnofsky Performance Status; Male; Middle Aged; Neoplasm Recurrence, Local; Temozolomide | 2011 |
North Central Cancer Treatment Group Phase I trial N057K of everolimus (RAD001) and temozolomide in combination with radiation therapy in patients with newly diagnosed glioblastoma multiforme.
Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Everolimus; Female; Fluorodeoxyglucose F18; Follow-Up Studies; Glioblastoma; Humans; Male; Middle Aged; Positron-Emission Tomography; Radiopharmaceuticals; Sirolimus; Temozolomide | 2011 |
Immunologic escape after prolonged progression-free survival with epidermal growth factor receptor variant III peptide vaccination in patients with newly diagnosed glioblastoma.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cancer Vaccines; Chemotherapy, Adjuvant; Dacarbazine; Disease-Free Survival; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Drug Administration Schedule; Enzyme-Linked Immunosorbent Assay; ErbB Receptors; Female; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Immunohistochemistry; Injections, Intradermal; Magnetic Resonance Imaging; Male; Middle Aged; Mutation; Predictive Value of Tests; Prognosis; Prospective Studies; Radiotherapy, Adjuvant; Sample Size; Temozolomide; Time Factors; Tumor Suppressor Proteins; United States | 2010 |
Favorable outcome in the elderly cohort treated by concomitant temozolomide radiochemotherapy in a multicentric phase II safety study of 5-ALA.
Topics: Aged; Aged, 80 and over; Aminolevulinic Acid; Antineoplastic Agents; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Female; Glioma; Humans; Kaplan-Meier Estimate; Karnofsky Performance Status; Male; Middle Aged; Photosensitizing Agents; Radiotherapy; Temozolomide; Treatment Outcome | 2011 |
Phase I trial of hypofractionated intensity-modulated radiotherapy with temozolomide chemotherapy for patients with newly diagnosed glioblastoma multiforme.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemoradiotherapy; Chemotherapy, Adjuvant; Dacarbazine; Dose Fractionation, Radiation; Drug Administration Schedule; Female; Glioblastoma; Humans; Karnofsky Performance Status; Magnetic Resonance Imaging; Male; Maximum Tolerated Dose; Middle Aged; Neoplasm Recurrence, Local; Neoplasm, Residual; Prospective Studies; Radiotherapy, Intensity-Modulated; Temozolomide; Tumor Burden | 2011 |
A phase I trial of tipifarnib with radiation therapy, with and without temozolomide, for patients with newly diagnosed glioblastoma.
Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Chemoradiotherapy; Dacarbazine; Female; Glioblastoma; Humans; Male; Middle Aged; Quinolones; Temozolomide | 2011 |
Phase I dose escalation trial of vandetanib with fractionated radiosurgery in patients with recurrent malignant gliomas.
Topics: Administration, Oral; Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Camptothecin; Carboplatin; Cohort Studies; Combined Modality Therapy; Dacarbazine; Dexamethasone; Drug Administration Schedule; Female; Glioma; Glucocorticoids; Humans; Irinotecan; Male; Maximum Tolerated Dose; Middle Aged; Neoplasm Recurrence, Local; Piperidines; Prospective Studies; Quinazolines; Radiosurgery; Radiotherapy Dosage; Temozolomide; Tumor Burden; Vincristine; Young Adult | 2012 |
Addition of bevacizumab to standard radiation therapy and daily temozolomide is associated with minimal toxicity in newly diagnosed glioblastoma multiforme.
Topics: Adult; Aged; Aged, 80 and over; Angiogenesis Inhibitors; Antibodies, Monoclonal, Humanized; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Brain Neoplasms; Camptothecin; Chemoradiotherapy; Craniotomy; Dacarbazine; Dexamethasone; Dose Fractionation, Radiation; Drug Administration Schedule; Female; Glioblastoma; Glucocorticoids; Humans; Injections, Intravenous; Irinotecan; Magnetic Resonance Imaging; Male; Middle Aged; Temozolomide; Tumor Burden; Young Adult | 2012 |
The outcomes of concomitant radiation plus temozolomide followed by adjuvant temozolomide for newly diagnosed high grade gliomas: the preliminary results of single center prospective study.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Chemotherapy, Adjuvant; Combined Modality Therapy; Cranial Irradiation; Dacarbazine; Female; Follow-Up Studies; Humans; Male; Maximum Tolerated Dose; Middle Aged; Prospective Studies; Survival Rate; Temozolomide; Treatment Outcome; Young Adult | 2009 |
Phase II study of bevacizumab plus temozolomide during and after radiation therapy for patients with newly diagnosed glioblastoma multiforme.
Topics: Adult; Aged; Aged, 80 and over; Angiogenesis Inhibitors; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Female; Glioblastoma; Humans; Male; Middle Aged; Prospective Studies; Temozolomide | 2011 |
Greater chemotherapy-induced lymphopenia enhances tumor-specific immune responses that eliminate EGFRvIII-expressing tumor cells in patients with glioblastoma.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemotherapy, Adjuvant; Cohort Studies; Dacarbazine; DNA Methylation; ErbB Receptors; Female; Glioblastoma; Humans; Hypersensitivity, Delayed; Immunoenzyme Techniques; Lymphopenia; Male; Middle Aged; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Survival Rate; T-Lymphocytes; T-Lymphocytes, Regulatory; Temozolomide; Treatment Outcome; Vaccines, Subunit | 2011 |
A multicenter phase I trial of combination therapy with interferon-β and temozolomide for high-grade gliomas (INTEGRA study): the final report.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Dacarbazine; Disease-Free Survival; Female; Glioma; Humans; Interferon-beta; Kaplan-Meier Estimate; Male; Middle Aged; Neoplasm Grading; Temozolomide | 2011 |
Temozolomide in the treatment of high-grade gliomas in children: a report from the Children's Oncology Group.
Topics: Adolescent; Adult; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemotherapy, Adjuvant; Child; Child, Preschool; Combined Modality Therapy; Dacarbazine; Female; Follow-Up Studies; Glioblastoma; Gliosarcoma; Humans; Immunoenzyme Techniques; Male; O(6)-Methylguanine-DNA Methyltransferase; Radiotherapy Dosage; Survival Rate; Temozolomide; Treatment Outcome; Young Adult | 2011 |
Phase I clinical trial assessing temozolomide and tamoxifen with concomitant radiotherapy for treatment of high-grade glioma.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Chemoradiotherapy; Cohort Studies; Dacarbazine; Drug Administration Schedule; Female; Glioblastoma; Glioma; Humans; Karnofsky Performance Status; Male; Maximum Tolerated Dose; Middle Aged; Protein Kinase C; Survival Rate; Tamoxifen; Temozolomide; Thrombocytopenia; Venous Thrombosis; Young Adult | 2012 |
Temozolomide and 13-cis retinoic acid in patients with anaplastic gliomas: a prospective single-arm monocentric phase-II study (RNOP-05).
Topics: Administration, Oral; Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Dacarbazine; Disease-Free Survival; Diterpenes; DNA Modification Methylases; DNA Repair Enzymes; Drug Administration Schedule; Female; Glioma; Humans; Isocitrate Dehydrogenase; Male; Middle Aged; Mutation; Prospective Studies; Retinaldehyde; Temozolomide; Tumor Suppressor Proteins; Young Adult | 2011 |
Patterns of failure for glioblastoma multiforme following concurrent radiation and temozolomide.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Female; Glioblastoma; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Radiotherapy, Conformal; Temozolomide; Treatment Failure; Treatment Outcome | 2011 |
AVAglio: Phase 3 trial of bevacizumab plus temozolomide and radiotherapy in newly diagnosed glioblastoma multiforme.
Topics: Adult; Angiogenesis Inhibitors; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents, Alkylating; Bevacizumab; Brain Neoplasms; Clinical Protocols; Clinical Trials, Phase III as Topic; Combined Modality Therapy; Dacarbazine; Europe; Glioblastoma; Humans; Prognosis; Radiotherapy; Recurrence; Standard of Care; Temozolomide; Treatment Outcome | 2011 |
Phase II clinical study of boron neutron capture therapy combined with X-ray radiotherapy/temozolomide in patients with newly diagnosed glioblastoma multiforme--study design and current status report.
Topics: Antineoplastic Agents; Boron Neutron Capture Therapy; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Glioblastoma; Humans; Temozolomide | 2011 |
Prognostic impact of CD133 mRNA expression in 48 glioblastoma patients treated with concomitant radiochemotherapy: a prospective patient cohort at a single institution.
Topics: AC133 Antigen; Adult; Aged; Antigens, CD; Antineoplastic Agents, Alkylating; Biomarkers, Tumor; Brain Neoplasms; Chemoradiotherapy; Cohort Studies; Dacarbazine; Female; Follow-Up Studies; Glioblastoma; Glycoproteins; Humans; Male; Middle Aged; Neoplasm Staging; Peptides; Prospective Studies; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Survival Rate; Temozolomide; Treatment Outcome | 2011 |
Phase II study of aflibercept in recurrent malignant glioma: a North American Brain Tumor Consortium study.
Topics: Adult; Aged; Antineoplastic Agents; Brain Neoplasms; Chemotherapy, Adjuvant; Cohort Studies; Dacarbazine; Disease Progression; Disease-Free Survival; Female; Glioblastoma; Glioma; Humans; Male; Middle Aged; North America; Receptors, Vascular Endothelial Growth Factor; Recombinant Fusion Proteins; Recurrence; Temozolomide; Vascular Endothelial Growth Factor A | 2011 |
Central nervous system failure in melanoma patients: results of a randomised, multicentre phase 3 study of temozolomide- and dacarbazine- based regimens.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Blood-Brain Barrier; Brain Neoplasms; Dacarbazine; Female; Humans; Male; Melanoma; Middle Aged; Skin Neoplasms; Temozolomide | 2011 |
Temozolomide in elderly patients with newly diagnosed glioblastoma and poor performance status: an ANOCEF phase II trial.
Topics: Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cognition; Dacarbazine; Disease-Free Survival; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Drug Administration Schedule; Female; France; Glioblastoma; Humans; Kaplan-Meier Estimate; Karnofsky Performance Status; Male; Polymerase Chain Reaction; Prospective Studies; Quality of Life; Surveys and Questionnaires; Temozolomide; Treatment Outcome; Tumor Suppressor Proteins | 2011 |
A phase I trial of the farnesyl transferase inhibitor, SCH 66336, with temozolomide for patients with malignant glioma.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carotenoids; Dacarbazine; Disease-Free Survival; Drug Combinations; Enzyme Inhibitors; Fatty Acids, Unsaturated; Female; Glioma; Humans; Kaplan-Meier Estimate; Male; Maximum Tolerated Dose; Middle Aged; Neoplasm Grading; Piperidines; Pyridines; Temozolomide; Vitamin E | 2011 |
MRI and thallium-201 SPECT in the prediction of survival in glioma.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Female; Glioma; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Netherlands; Prevalence; Prognosis; Radiopharmaceuticals; Reproducibility of Results; Risk Assessment; Sensitivity and Specificity; Survival Analysis; Survival Rate; Temozolomide; Thallium Radioisotopes; Treatment Outcome; Young Adult | 2012 |
Monoclonal antibody blockade of IL-2 receptor α during lymphopenia selectively depletes regulatory T cells in mice and humans.
Topics: Adult; Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cancer Vaccines; Cells, Cultured; Combined Modality Therapy; Dacarbazine; Daclizumab; Drug Evaluation, Preclinical; Glioblastoma; Humans; Immunoglobulin G; Immunotherapy; Interleukin-2 Receptor alpha Subunit; Lymphocyte Depletion; Lymphopenia; Mice; Mice, Inbred C57BL; Mice, Transgenic; Middle Aged; Substrate Specificity; T-Lymphocytes, Regulatory; Temozolomide; Young Adult | 2011 |
Bevacizumab and daily temozolomide for recurrent glioblastoma.
Topics: Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Drug Administration Schedule; Female; Glioblastoma; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Survival Analysis; Temozolomide; Treatment Outcome | 2012 |
Phase 2 trial of temozolomide and pegylated liposomal doxorubicin in the treatment of patients with glioblastoma multiforme following concurrent radiotherapy and chemotherapy.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Dacarbazine; Disease-Free Survival; Doxorubicin; Drug Administration Schedule; Female; Glioblastoma; Humans; Male; Middle Aged; Polyethylene Glycols; Prospective Studies; Survival Rate; Temozolomide; Treatment Outcome | 2011 |
Phase IB study of gene-mediated cytotoxic immunotherapy adjuvant to up-front surgery and intensive timing radiation for malignant glioma.
Topics: Acyclovir; Adenoviridae; Adjuvants, Immunologic; Adult; Aged; Antineoplastic Agents, Alkylating; Antiviral Agents; Brain Neoplasms; Cancer Vaccines; Combined Modality Therapy; Dacarbazine; Genetic Therapy; Genetic Vectors; Glioma; Herpesvirus 1, Human; Humans; Immunotherapy; Middle Aged; O(6)-Methylguanine-DNA Methyltransferase; Temozolomide; Thymidine Kinase; Treatment Outcome; Valacyclovir; Valine | 2011 |
Prolonged survival with valproic acid use in the EORTC/NCIC temozolomide trial for glioblastoma.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Canada; Dacarbazine; Europe; Female; Glioblastoma; Humans; Male; Middle Aged; Retrospective Studies; Survival Rate; Temozolomide; Valproic Acid; Young Adult | 2011 |
Phase II and pharmacogenomics study of enzastaurin plus temozolomide during and following radiation therapy in patients with newly diagnosed glioblastoma multiforme and gliosarcoma.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Brain; Brain Neoplasms; Case-Control Studies; Chemoradiotherapy; Chemotherapy, Adjuvant; Clinical Trials, Phase III as Topic; Dacarbazine; DNA Methylation; DNA, Neoplasm; Female; Follow-Up Studies; Glioblastoma; Gliosarcoma; Humans; Immunoenzyme Techniques; Indoles; Male; Middle Aged; Neoplasm Staging; Pharmacogenetics; Polymerase Chain Reaction; Prospective Studies; Survival Rate; Temozolomide; Treatment Outcome; Young Adult | 2011 |
Efficacy and toxicity of CyberKnife re-irradiation and "dose dense" temozolomide for recurrent gliomas.
Topics: Antineoplastic Agents, Alkylating; Asthenia; Brain Neoplasms; Dacarbazine; Disease-Free Survival; Female; Glioblastoma; Hematologic Diseases; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Radiosurgery; Reoperation; Survival Rate; Temozolomide; Vomiting | 2012 |
Prognostic factors and survival in a prospective cohort of patients with high-grade glioma treated with carmustine wafers or temozolomide on an intention-to-treat basis.
Topics: Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carmustine; Chemotherapy, Adjuvant; Cohort Studies; Dacarbazine; Female; Follow-Up Studies; Glioma; Humans; Karnofsky Performance Status; Male; Middle Aged; Neoplasm Grading; Prognosis; Prospective Studies; Radiotherapy, Adjuvant; Retrospective Studies; Survival Rate; Temozolomide | 2012 |
A clinical trial of bevacizumab, temozolomide, and radiation for newly diagnosed glioblastoma.
Topics: Adult; Aged; Angiogenesis Inhibitors; Antibodies, Monoclonal, Humanized; Antineoplastic Agents, Alkylating; Bevacizumab; Brain Neoplasms; Chemoradiotherapy; Dacarbazine; Disease-Free Survival; Drug Therapy, Combination; Female; Glioblastoma; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Morbidity; Prognosis; Recurrence; Temozolomide; Treatment Outcome | 2012 |
Phase II study of short-course radiotherapy plus concomitant and adjuvant temozolomide in elderly patients with glioblastoma.
Topics: Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemoradiotherapy; Chemotherapy, Adjuvant; Dacarbazine; Disease-Free Survival; Dose Fractionation, Radiation; Drug Administration Schedule; Female; Glioblastoma; Humans; Karnofsky Performance Status; Male; Neutropenia; Temozolomide; Thrombocytopenia | 2012 |
Outcome, quality of life and cognitive function of patients with brain metastases from non-small cell lung cancer treated with whole brain radiotherapy combined with gefitinib or temozolomide. A randomised phase II trial of the Swiss Group for Clinical Ca
Topics: Aged; Aged, 80 and over; Antineoplastic Agents; Brain Neoplasms; Brief Psychiatric Rating Scale; Carcinoma, Non-Small-Cell Lung; Chemoradiotherapy; Cognition; Cranial Irradiation; Dacarbazine; Female; Gefitinib; Humans; Lung Neoplasms; Male; Middle Aged; Outcome Assessment, Health Care; Quality of Life; Quinazolines; Survival Analysis; Temozolomide | 2012 |
Going past the data for temozolomide.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemotherapy, Adjuvant; Dacarbazine; Glioblastoma; Humans; Temozolomide; Treatment Outcome | 2012 |
A phase I study of temozolomide and everolimus (RAD001) in patients with newly diagnosed and progressive glioblastoma either receiving or not receiving enzyme-inducing anticonvulsants: an NCIC CTG study.
Topics: Adult; Aged; Anticonvulsants; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Dacarbazine; Drug Combinations; Everolimus; Female; Glioblastoma; Humans; Immunosuppressive Agents; Male; Middle Aged; PTEN Phosphohydrolase; Sirolimus; Temozolomide; Young Adult | 2012 |
A clinical review of treatment outcomes in glioblastoma multiforme--the validation in a non-trial population of the results of a randomised Phase III clinical trial: has a more radical approach improved survival?
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemoradiotherapy, Adjuvant; Dacarbazine; Female; Glioblastoma; Humans; Ireland; Male; Middle Aged; Prevalence; Radiotherapy, Conformal; Survival Analysis; Survival Rate; Temozolomide; Treatment Outcome; Young Adult | 2012 |
Whole-brain irradiation with concomitant daily fixed-dose temozolomide for brain metastases treatment: a randomised phase II trial.
Topics: Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chi-Square Distribution; Cranial Irradiation; Dacarbazine; Dose Fractionation, Radiation; Female; Humans; Male; Middle Aged; Proportional Hazards Models; Radiotherapy Dosage; Survival Rate; Temozolomide; Treatment Outcome | 2012 |
A phase I study of LY317615 (enzastaurin) and temozolomide in patients with gliomas (EORTC trial 26054).
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Dacarbazine; Female; Glioblastoma; Humans; Indoles; Male; Maximum Tolerated Dose; Middle Aged; Temozolomide; Young Adult | 2012 |
Phase II study of Gleevec plus hydroxyurea in adults with progressive or recurrent low-grade glioma.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Benzamides; Brain Neoplasms; Cohort Studies; Dacarbazine; Diarrhea; Disease Progression; Disease-Free Survival; Drug Administration Schedule; Female; Humans; Hydroxyurea; Imatinib Mesylate; Male; Middle Aged; Neoplasm Recurrence, Local; Neutropenia; Oligodendroglioma; Piperazines; Pyrimidines; Temozolomide; Thrombocytopenia; Treatment Outcome | 2012 |
[Comparison of two regimens of postoperative concurrent chemoradiotherapy in adult patients with grade III-IV cerebral gliomas].
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Chemoradiotherapy; Dacarbazine; Female; Glioma; Humans; Male; Middle Aged; Postoperative Period; Semustine; Temozolomide; Teniposide; Young Adult | 2012 |
Results of phase I study of a multi-modality treatment for newly diagnosed glioblastoma multiforme using local implantation of concurrent BCNU wafers and permanent I-125 seeds followed by fractionated radiation and temozolomide chemotherapy.
Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carmustine; Chemoradiotherapy; Dacarbazine; Female; Glioblastoma; Humans; Iodine Radioisotopes; Male; Middle Aged; Prognosis; Prospective Studies; Temozolomide | 2012 |
Phase II trial of hypofractionated IMRT with temozolomide for patients with newly diagnosed glioblastoma multiforme.
Topics: Adult; Aged; Anti-Inflammatory Agents; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemoradiotherapy; Chemotherapy, Adjuvant; Dacarbazine; Dexamethasone; Dose Fractionation, Radiation; Female; Glioblastoma; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Prospective Studies; Reoperation; Temozolomide; Tumor Burden | 2012 |
A safety run-in and randomized phase 2 study of cilengitide combined with chemoradiation for newly diagnosed glioblastoma (NABTT 0306).
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemoradiotherapy; Combined Modality Therapy; Dacarbazine; Disease-Free Survival; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Female; Glioblastoma; Humans; Integrins; Male; Middle Aged; Snake Venoms; Temozolomide; Treatment Outcome; Tumor Suppressor Proteins; Young Adult | 2012 |
Quality assurance in the EORTC 22033-26033/CE5 phase III randomized trial for low grade glioma: the digital individual case review.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Electronic Health Records; Glioma; Humans; Quality Assurance, Health Care; Radiotherapy Dosage; Temozolomide | 2012 |
Temozolomide chemotherapy alone versus radiotherapy alone for malignant astrocytoma in the elderly: the NOA-08 randomised, phase 3 trial.
Topics: Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Dacarbazine; Disease-Free Survival; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Female; Humans; Isocitrate Dehydrogenase; Male; Promoter Regions, Genetic; Temozolomide; Tumor Suppressor Proteins | 2012 |
Impact of age and co-morbidities in patients with newly diagnosed glioblastoma: a pooled data analysis of three prospective mono-institutional phase II studies.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Antineoplastic Agents; Brain Neoplasms; Combined Modality Therapy; Comorbidity; Dacarbazine; Disease-Free Survival; Female; Glioblastoma; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Radiosurgery; Radiotherapy; Temozolomide; Young Adult | 2012 |
A phase I study of the combination of sorafenib with temozolomide and radiation therapy for the treatment of primary and recurrent high-grade gliomas.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cell Line, Tumor; Cell Survival; Chemoradiotherapy; Dacarbazine; Female; Glioma; Humans; Male; Maximum Tolerated Dose; Middle Aged; Neoplasm Proteins; Neoplasm Recurrence, Local; Niacinamide; Phenylurea Compounds; Radiotherapy Dosage; Sorafenib; Temozolomide; Vascular Endothelial Growth Factor A | 2013 |
Phase II study of concurrent radiation therapy, temozolomide, and bevacizumab followed by bevacizumab/everolimus as first-line treatment for patients with glioblastoma.
Topics: Adult; Aged; Aged, 80 and over; Angiogenesis Inhibitors; Antibodies, Monoclonal, Humanized; Antineoplastic Agents, Alkylating; Bevacizumab; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Disease-Free Survival; Everolimus; Female; Glioblastoma; Humans; Immunosuppressive Agents; Male; Middle Aged; Sirolimus; Temozolomide; Young Adult | 2012 |
Phase I study of arsenic trioxide and temozolomide in combination with radiation therapy in patients with malignant gliomas.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Arsenic Trioxide; Arsenicals; Brain Neoplasms; Chemoradiotherapy; Dacarbazine; Dose Fractionation, Radiation; Female; Glioma; Humans; Male; Maximum Tolerated Dose; Middle Aged; Oxides; Prognosis; Radiotherapy Dosage; Survival Rate; Temozolomide | 2012 |
Temozolomide versus standard 6-week radiotherapy versus hypofractionated radiotherapy in patients older than 60 years with glioblastoma: the Nordic randomised, phase 3 trial.
Topics: Aged; Aged, 80 and over; Brain Neoplasms; Chemoradiotherapy, Adjuvant; Dacarbazine; Disease-Free Survival; Dose Fractionation, Radiation; Evidence-Based Medicine; Female; Glioblastoma; Humans; Male; Middle Aged; Palliative Care; Prognosis; Quality of Life; Survival Rate; Temozolomide; Treatment Outcome | 2012 |
Diffusion-weighted MR imaging for the differentiation of true progression from pseudoprogression following concomitant radiotherapy with temozolomide in patients with newly diagnosed high-grade gliomas.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents, Alkylating; Artifacts; Brain Neoplasms; Chemoradiotherapy; Dacarbazine; Diagnosis, Differential; Diffusion Magnetic Resonance Imaging; Female; Glioma; Humans; Male; Reproducibility of Results; Sensitivity and Specificity; Temozolomide; Treatment Outcome; Young Adult | 2012 |
Accelerated intensity-modulated radiotherapy plus temozolomide in patients with glioblastoma: a phase I dose-escalation study (ISIDE-BT-1).
Topics: Adult; Aged; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Dose Fractionation, Radiation; Female; Glioblastoma; Humans; Male; Maximum Tolerated Dose; Middle Aged; Neoplasm Recurrence, Local; Radiotherapy, Intensity-Modulated; Temozolomide | 2013 |
Chemosensitized radiosurgery for recurrent brain metastases.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Female; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Neoplasms; Pilot Projects; Prognosis; Radiosurgery; Survival Rate; Temozolomide | 2012 |
Phase I study of vorinostat in combination with temozolomide in patients with high-grade gliomas: North American Brain Tumor Consortium Study 04-03.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Dacarbazine; Female; Glioma; Humans; Hydroxamic Acids; Male; Middle Aged; Neoplasm Grading; Temozolomide; Treatment Outcome; Vorinostat | 2012 |
The addition of temozolomide does not change the pattern of progression of glioblastoma multiforme post-radiotherapy.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemotherapy, Adjuvant; Dacarbazine; Disease Progression; Female; Glioblastoma; Humans; Incidence; Male; Middle Aged; Radiotherapy, Conformal; Risk Factors; Survival Analysis; Survival Rate; Temozolomide; Treatment Outcome; Victoria | 2012 |
Human umbilical vein endothelial cell vaccine therapy in patients with recurrent glioblastoma.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Cancer Vaccines; Chemotherapy, Adjuvant; Dacarbazine; Disease Progression; Disease-Free Survival; Female; Glioblastoma; Human Umbilical Vein Endothelial Cells; Humans; Immunotherapy, Active; Male; Middle Aged; Nimustine; Temozolomide | 2013 |
Limited margins using modern radiotherapy techniques does not increase marginal failure rate of glioblastoma.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Dose-Response Relationship, Radiation; Female; Glioblastoma; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Radiotherapy, Intensity-Modulated; Temozolomide; Treatment Failure; Young Adult | 2014 |
Phase II trial of continuous low-dose temozolomide for patients with recurrent malignant glioma.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Glioma; Humans; Male; Maximum Tolerated Dose; Middle Aged; Neoplasm Grading; Neoplasm Recurrence, Local; Prognosis; Prospective Studies; Survival Rate; Temozolomide | 2013 |
A phase I study of temozolomide and lapatinib combination in patients with recurrent high-grade gliomas.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Dacarbazine; Disease-Free Survival; Dose-Response Relationship, Drug; Female; Glioma; Humans; Kaplan-Meier Estimate; Lapatinib; Male; Maximum Tolerated Dose; Middle Aged; Neoplasm Grading; Neoplasm Recurrence, Local; Quinazolines; Temozolomide | 2013 |
"One week on-one week off": efficacy and side effects of dose-intensified temozolomide chemotherapy: experiences of a single center.
Topics: Adult; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Disease Progression; Drug Administration Schedule; Female; Follow-Up Studies; Glioma; Humans; Middle Aged; Neoplasm Grading; Neoplasm Recurrence, Local; Prognosis; Retrospective Studies; Survival Rate; Temozolomide | 2013 |
Prospective study of carmustine wafers in combination with 6-month metronomic temozolomide and radiation therapy in newly diagnosed glioblastoma: preliminary results.
Topics: Administration, Metronomic; Administration, Oral; Adolescent; Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Carmustine; Combined Modality Therapy; Dacarbazine; Drug Therapy, Combination; Female; Follow-Up Studies; Glioblastoma; Humans; Karnofsky Performance Status; Longitudinal Studies; Male; Middle Aged; Neurosurgical Procedures; Prospective Studies; Radiotherapy; Survival Rate; Temozolomide; Treatment Outcome; Young Adult | 2013 |
Paclitaxel poliglumex, temozolomide, and radiation for newly diagnosed high-grade glioma: a Brown University Oncology Group Study.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brachytherapy; Brain Neoplasms; Chemoradiotherapy; Combined Modality Therapy; Dacarbazine; Disease-Free Survival; Female; Glioma; Humans; Male; Middle Aged; Paclitaxel; Polyglutamic Acid; Survival Analysis; Temozolomide | 2014 |
Can elderly patients with newly diagnosed glioblastoma be enrolled in radiochemotherapy trials?
Topics: Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemoradiotherapy; Chemoradiotherapy, Adjuvant; Dacarbazine; Disease-Free Survival; Female; Glioblastoma; Humans; Kaplan-Meier Estimate; Karnofsky Performance Status; Male; Patient Selection; Radiotherapy, Conformal; Retrospective Studies; Temozolomide; Treatment Outcome | 2015 |
A phase 3 trial of whole brain radiation therapy and stereotactic radiosurgery alone versus WBRT and SRS with temozolomide or erlotinib for non-small cell lung cancer and 1 to 3 brain metastases: Radiation Therapy Oncology Group 0320.
Topics: Aged; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Brain Neoplasms; Carcinoma, Non-Small-Cell Lung; Combined Modality Therapy; Cranial Irradiation; Dacarbazine; Erlotinib Hydrochloride; Humans; Lung Neoplasms; Middle Aged; Protein Kinase Inhibitors; Quinazolines; Radiosurgery; Radiotherapy Dosage; Temozolomide | 2013 |
Phase II randomized trial of temozolomide and concurrent radiotherapy in patients with brain metastases.
Topics: Analysis of Variance; Antineoplastic Agents, Alkylating; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Dose Fractionation, Radiation; Female; Humans; Male; Middle Aged; Pilot Projects; Radiotherapy; Survival Rate; Temozolomide | 2002 |
A phase II pilot trial of concurrent biochemotherapy with cisplatin, vinblastine, temozolomide, interleukin 2, and IFN-alpha 2B in patients with metastatic melanoma.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cisplatin; Dacarbazine; Disease-Free Survival; Female; Granulocyte Colony-Stimulating Factor; Humans; Infusions, Intravenous; Interferon alpha-2; Interferon-alpha; Interleukin-2; Male; Melanoma; Middle Aged; Pilot Projects; Recombinant Proteins; Temozolomide; Treatment Outcome; Vinblastine | 2002 |
Temozolomide in second-line treatment after prior nitrosurea-based chemotherapy in glioblastoma multiforme: experience from a Portuguese institution.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Drug Administration Schedule; Glioblastoma; Humans; Middle Aged; Portugal; Survival Analysis; Survival Rate; Temozolomide; Treatment Outcome | 2002 |
Temozolomide in malignant gliomas of childhood: a United Kingdom Children's Cancer Study Group and French Society for Pediatric Oncology Intergroup Study.
Topics: Adolescent; Antineoplastic Agents, Alkylating; Bone Marrow; Brain Neoplasms; Child; Child, Preschool; Dacarbazine; Female; Glioma; Humans; Male; Temozolomide; Thrombocytopenia | 2002 |
Second-line chemotherapy with temozolomide in recurrent oligodendroglioma after PCV (procarbazine, lomustine and vincristine) chemotherapy: EORTC Brain Tumor Group phase II study 26972.
Topics: Adult; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Dacarbazine; Disease Progression; Drug Resistance, Neoplasm; Female; Humans; Lomustine; Magnetic Resonance Imaging; Male; Middle Aged; Neoplasm Recurrence, Local; Oligodendroglioma; Procarbazine; Temozolomide; Treatment Outcome; Vincristine | 2003 |
Phase I study of temozolomide and escalating doses of oral etoposide for adults with recurrent malignant glioma.
Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Dacarbazine; Dose-Response Relationship, Drug; Etoposide; Female; Glioma; Humans; Male; Maximum Tolerated Dose; Middle Aged; Neoplasm Recurrence, Local; Survival Rate; Temozolomide; Treatment Outcome | 2003 |
Temozolomide in patients with advanced non-small cell lung cancer with and without brain metastases. a phase II study of the EORTC Lung Cancer Group (08965).
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Carcinoma, Non-Small-Cell Lung; Dacarbazine; Female; Humans; Lung Neoplasms; Male; Middle Aged; Temozolomide; Treatment Outcome | 2003 |
Phase II study of first-line chemotherapy with temozolomide in recurrent oligodendroglial tumors: the European Organization for Research and Treatment of Cancer Brain Tumor Group Study 26971.
Topics: Adult; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Disease Progression; Drug Administration Schedule; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Neoplasm Recurrence, Local; Oligodendroglioma; Temozolomide; Treatment Outcome | 2003 |
Phase I study of temozolamide (TMZ) combined with procarbazine (PCB) in patients with gliomas.
Topics: Administration, Oral; Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Dacarbazine; Female; Glioblastoma; Glioma; Humans; Male; Middle Aged; Procarbazine; Sleep Stages; Temozolomide; Thrombocytopenia; Treatment Outcome | 2003 |
Phase II study of temozolomide plus thalidomide for the treatment of metastatic melanoma.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Dacarbazine; Dose-Response Relationship, Drug; Female; Humans; Male; Melanoma; Middle Aged; Survival Analysis; Temozolomide; Thalidomide; Treatment Outcome | 2003 |
Population pharmacokinetics of temozolomide and metabolites in infants and children with primary central nervous system tumors.
Topics: Adolescent; Adult; Age Factors; Antineoplastic Agents, Alkylating; Area Under Curve; Biological Availability; Body Surface Area; Brain Neoplasms; Child; Child, Preschool; Chromatography, High Pressure Liquid; Dacarbazine; Female; Humans; Infant; Linear Models; Male; Metabolic Clearance Rate; Reproducibility of Results; Temozolomide | 2003 |
Pharmacokinetics of temozolomide given three times a day in pediatric and adult patients.
Topics: Administration, Oral; Adolescent; Adult; Antineoplastic Agents, Alkylating; Area Under Curve; Brain Neoplasms; Child; Child, Preschool; Dacarbazine; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Half-Life; Humans; Linear Models; Male; Metabolic Clearance Rate; Middle Aged; Neutropenia; Temozolomide; Thrombocytopenia | 2003 |
A first feasibility study of temozolomide for Japanese patients with recurrent anaplastic astrocytoma and glioblastoma multiforme.
Topics: Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Dacarbazine; Disease Progression; Dose-Response Relationship, Drug; Feasibility Studies; Female; Glioblastoma; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Palliative Care; Survival Rate; Temozolomide | 2003 |
Phase II study of primary temozolomide chemotherapy in patients with WHO grade II gliomas.
Topics: Administration, Oral; Adult; Antineoplastic Agents; Brain Neoplasms; Dacarbazine; Disease Progression; Disease-Free Survival; Female; Glioma; Humans; Male; Middle Aged; Seizures; Temozolomide; Treatment Outcome | 2003 |
Temozolomide chemotherapy for progressive low-grade glioma: clinical benefits and radiological response.
Topics: Administration, Oral; Adult; Aged; Antineoplastic Agents; Brain Neoplasms; Dacarbazine; Disease Progression; Disease-Free Survival; Female; Glioma; Humans; Male; Middle Aged; Neoplasm Staging; Quality of Life; Radiography; Seizures; Temozolomide; Treatment Outcome | 2003 |
Dose-dense regimen of temozolomide given every other week in patients with primary central nervous system tumors.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Dacarbazine; Disease Progression; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Ondansetron; Temozolomide | 2004 |
Temozolomide in the treatment of recurrent malignant glioma.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents, Alkylating; Biopsy, Needle; Brain Neoplasms; Dacarbazine; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Follow-Up Studies; Glioma; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Multivariate Analysis; Neoplasm Recurrence, Local; Neoplasm Staging; Probability; Proportional Hazards Models; Risk Assessment; Survival Analysis; Temozolomide; Treatment Outcome | 2004 |
Phase 2 study of BCNU and temozolomide for recurrent glioblastoma multiforme: North American Brain Tumor Consortium study.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carmustine; Confidence Intervals; Dacarbazine; Disease-Free Survival; Female; Glioblastoma; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; North America; Temozolomide | 2004 |
Phase 2 study of temozolomide and Caelyx in patients with recurrent glioblastoma multiforme.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Confidence Intervals; Dacarbazine; Disease-Free Survival; Doxorubicin; Female; Glioblastoma; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Temozolomide | 2004 |
Monitoring temozolomide treatment of low-grade glioma with proton magnetic resonance spectroscopy.
Topics: Administration, Oral; Adult; Antineoplastic Agents, Alkylating; Brain Neoplasms; Choline; Dacarbazine; Female; Glioma; Humans; Magnetic Resonance Spectroscopy; Male; Temozolomide; Treatment Outcome; Water | 2004 |
Phase II trial of cisplatin plus temozolomide, in recurrent and progressive malignant glioma patients.
Topics: Adult; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Blood; Brain Neoplasms; Cisplatin; Dacarbazine; Disease Progression; Drug Administration Schedule; Female; Glioma; Humans; Male; Middle Aged; Survival Analysis; Temozolomide | 2004 |
Fotemustine compared with dacarbazine in patients with disseminated malignant melanoma: a phase III study.
Topics: Adult; Aged; Antineoplastic Agents; Brain Neoplasms; Dacarbazine; Disease-Free Survival; Europe; Female; Humans; Male; Melanoma; Middle Aged; Nitrosourea Compounds; Organophosphorus Compounds; Quality of Life; Skin Neoplasms; Statistics, Nonparametric; Survival Analysis | 2004 |
Salvage chemotherapy with cyclophosphamide for recurrent, temozolomide-refractory glioblastoma multiforme.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemotherapy, Adjuvant; Cyclophosphamide; Dacarbazine; Drug Resistance, Neoplasm; Female; Glioblastoma; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Neoplasm Recurrence, Local; Prospective Studies; Salvage Therapy; Temozolomide; Treatment Outcome | 2004 |
Clinical trial substantiates the predictive value of O-6-methylguanine-DNA methyltransferase promoter methylation in glioblastoma patients treated with temozolomide.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Biopsy; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; DNA Methylation; Female; Glioblastoma; Humans; Male; Middle Aged; Multivariate Analysis; O(6)-Methylguanine-DNA Methyltransferase; Predictive Value of Tests; Promoter Regions, Genetic; Proportional Hazards Models; Survival Analysis; Temozolomide; Time Factors | 2004 |
Phase II study of neoadjuvant 1, 3-bis (2-chloroethyl)-1-nitrosourea and temozolomide for newly diagnosed anaplastic glioma: a North American Brain Tumor Consortium Trial.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carmustine; Dacarbazine; Disease Progression; Drug Resistance, Neoplasm; Female; Glioma; Humans; Male; Middle Aged; Neoadjuvant Therapy; Radiotherapy, Adjuvant; Survival Analysis; Temozolomide | 2004 |
BCNU as second line therapy for recurrent high-grade glioma previously treated with Temozolomide.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Carmustine; Dacarbazine; Disease Progression; Dose Fractionation, Radiation; Female; Follow-Up Studies; Glioma; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Temozolomide; Treatment Outcome | 2004 |
Temozolomide as prophylaxis for melanoma brain metastases.
Topics: Adult; Aged; Antibiotic Prophylaxis; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Female; Humans; Male; Melanoma; Middle Aged; Skin Neoplasms; Temozolomide | 2004 |
First-line chemotherapy with cisplatin plus fractionated temozolomide in recurrent glioblastoma multiforme: a phase II study of the Gruppo Italiano Cooperativo di Neuro-Oncologia.
Topics: Adult; Aged; Agranulocytosis; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cisplatin; Dacarbazine; Disease-Free Survival; Drug Administration Schedule; Drug Interactions; Female; Glioblastoma; Humans; Injections, Intravenous; Male; Middle Aged; Neoplasm Recurrence, Local; Temozolomide; Thrombocytopenia; Treatment Outcome | 2004 |
Phase II study of temozolomide without radiotherapy in newly diagnosed glioblastoma multiforme in an elderly populations.
Topics: Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Female; Glioblastoma; Humans; Male; Prognosis; Survival Rate; Temozolomide; Treatment Outcome | 2004 |
Temozolomide for the treatment of brain metastases associated with metastatic melanoma: a phase II study.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Disease-Free Survival; Female; Humans; Male; Melanoma; Middle Aged; Skin Neoplasms; Survival Rate; Temozolomide; United States | 2004 |
Phase I study pilot arms of radiotherapy and carmustine with temozolomide for anaplastic astrocytoma (Radiation Therapy Oncology Group 9813): implications for studies testing initial treatment of brain tumors.
Topics: Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Carmustine; Dacarbazine; Female; Humans; Male; Middle Aged; Pilot Projects; Temozolomide | 2004 |
Temozolomide in paediatric high-grade glioma: a key for combination therapy?
Topics: Administration, Oral; Adolescent; Adult; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Child; Child, Preschool; Combined Modality Therapy; Dacarbazine; Disease Progression; Drug Resistance, Neoplasm; Female; Glioma; Humans; Male; Temozolomide; Treatment Outcome | 2004 |
Initial chemotherapy in gliomatosis cerebri.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Combined Modality Therapy; Cranial Irradiation; Dacarbazine; Disease Progression; Disease-Free Survival; Drug Administration Schedule; Female; Hematologic Diseases; Humans; Karnofsky Performance Status; Lomustine; Magnetic Resonance Imaging; Male; Middle Aged; Neoplasms, Neuroepithelial; Oligodendroglioma; Procarbazine; Survival Analysis; Temozolomide; Treatment Outcome; Vincristine | 2004 |
Chemotherapy as initial treatment in gliomatosis cerebri: results with temozolomide.
Topics: Adolescent; Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Disease Progression; Disease-Free Survival; Female; Glioblastoma; Humans; Life Tables; Male; Middle Aged; Neoplasms, Neuroepithelial; Oligodendroglioma; Prospective Studies; Temozolomide; Treatment Outcome | 2004 |
Phase 1 study of 28-day, low-dose temozolomide and BCNU in the treatment of malignant gliomas after radiation therapy.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Carmustine; Dacarbazine; Drug Administration Schedule; Female; Glioblastoma; Glioma; Humans; Karnofsky Performance Status; Male; Middle Aged; Radiotherapy; Temozolomide | 2004 |
Immediate post-radiotherapy changes in malignant glioma can mimic tumor progression.
Topics: Antineoplastic Combined Chemotherapy Protocols; Artifacts; Astrocytoma; Brain Edema; Brain Neoplasms; Chemotherapy, Adjuvant; Clinical Trials, Phase III as Topic; Cohort Studies; Combined Modality Therapy; Contrast Media; Cranial Irradiation; Dacarbazine; Dexamethasone; Diagnosis, Differential; Disease Progression; Female; Follow-Up Studies; Gadolinium; Glioma; Humans; Lomustine; Magnetic Resonance Imaging; Male; Middle Aged; Patient Selection; Procarbazine; Temozolomide; Vincristine | 2004 |
The effect of temozolomide-based chemotherapy in patients with cerebral metastases from melanoma.
Topics: Adult; Aged; Brain Neoplasms; Dacarbazine; Disease Progression; Drug Therapy, Combination; Female; Humans; Male; Melanoma; Middle Aged; Neoplasm Staging; Prognosis; Survival Rate; Temozolomide; Time Factors | 2004 |
Salvage PCV chemotherapy for temozolomide-resistant oligodendrogliomas.
Topics: Adult; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Chromosomes, Human, Pair 1; Chromosomes, Human, Pair 19; Cohort Studies; Dacarbazine; Disease-Free Survival; Drug Resistance, Neoplasm; Female; Humans; Lomustine; Male; Middle Aged; Oligodendroglioma; Procarbazine; Remission Induction; Retrospective Studies; Salvage Therapy; Sequence Deletion; Temozolomide; Treatment Outcome; Vincristine | 2004 |
Temozolomide treatment in glioma--experiences in two university hospitals in Finland.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cost-Benefit Analysis; Dacarbazine; Disease-Free Survival; Drug Costs; Female; Glioma; Humans; Male; Middle Aged; Temozolomide; Treatment Outcome | 2004 |
Phase II study of temozolomide and thalidomide with radiation therapy for newly diagnosed glioblastoma multiforme.
Topics: Adult; Aged; Angiogenesis Inhibitors; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Drug Administration Schedule; Female; Follow-Up Studies; Glioblastoma; Humans; Male; Middle Aged; Temozolomide; Thalidomide | 2004 |
Combined treatment of glioblastoma patients with locoregional pre-targeted 90Y-biotin radioimmunotherapy and temozolomide.
Topics: Antineoplastic Agents, Alkylating; Biotin; Brain Neoplasms; Chemotherapy, Adjuvant; Combined Modality Therapy; Dacarbazine; Disease-Free Survival; Drug Delivery Systems; Female; Glioblastoma; Humans; Italy; Male; Middle Aged; Radioimmunotherapy; Radiopharmaceuticals; Survival Analysis; Temozolomide; Treatment Outcome; Yttrium Radioisotopes | 2004 |
Phase II study of concurrent continuous Temozolomide (TMZ) and Tamoxifen (TMX) for recurrent malignant astrocytic gliomas.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Dacarbazine; Female; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Salvage Therapy; Survival Rate; Tamoxifen; Temozolomide; Treatment Outcome | 2004 |
Second-line chemotherapy with irinotecan plus carmustine in glioblastoma recurrent or progressive after first-line temozolomide chemotherapy: a phase II study of the Gruppo Italiano Cooperativo di Neuro-Oncologia (GICNO).
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Camptothecin; Carmustine; Dacarbazine; Dose-Response Relationship, Drug; Drug Administration Schedule; Electroencephalography; Female; Follow-Up Studies; Glioblastoma; Humans; Irinotecan; Italy; Magnetic Resonance Imaging; Male; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Staging; Salvage Therapy; Survival Analysis; Temozolomide; Treatment Outcome | 2004 |
Temozolomide and concomitant whole brain radiotherapy in patients with brain metastases: a phase II randomized trial.
Topics: Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Combined Modality Therapy; Cranial Irradiation; Dacarbazine; Disease-Free Survival; Female; Humans; Male; Middle Aged; Temozolomide | 2005 |
Temozolomide chemotherapy of patients with recurrent anaplastic astrocytomas and glioblastomas.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Dacarbazine; Disease Progression; Disease-Free Survival; Drug Administration Schedule; Female; Glioblastoma; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Neoplasm Recurrence, Local; Survival Analysis; Temozolomide; Tomography, X-Ray Computed; Treatment Outcome | 2004 |
Phase II study of temozolomide and cisplatin as primary treatment prior to radiotherapy in newly diagnosed glioblastoma multiforme patients with measurable disease. A study of the Spanish Medical Neuro-Oncology Group (GENOM).
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cisplatin; Combined Modality Therapy; Dacarbazine; Female; Glioblastoma; Humans; Male; Middle Aged; Radiotherapy; Survival Analysis; Temozolomide; Treatment Outcome | 2004 |
Temozolomide (TMZ) combined with cisplatin (CDDP) in patients with brain metastases from solid tumors: a Hellenic Cooperative Oncology Group (HeCOG) Phase II study.
Topics: Adult; Aged; Alopecia; Anemia; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Breast Neoplasms; Cisplatin; Dacarbazine; Female; Humans; Leukopenia; Lung Neoplasms; Male; Melanoma; Middle Aged; Nausea; Stomach Neoplasms; Temozolomide; Treatment Outcome | 2005 |
Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma.
Topics: Adrenal Cortex Hormones; Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemotherapy, Adjuvant; Dacarbazine; Disease Progression; Female; Glioblastoma; Humans; Male; Middle Aged; Proportional Hazards Models; Radiotherapy, Computer-Assisted; Survival Analysis; Temozolomide | 2005 |
Randomized phase II study of temozolomide and radiotherapy compared with radiotherapy alone in newly diagnosed glioblastoma multiforme.
Topics: Adult; Antineoplastic Agents, Alkylating; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Disease Progression; Drug Administration Schedule; Female; Glioblastoma; Humans; Male; Middle Aged; Survival Analysis; Temozolomide | 2005 |
Cost of temozolomide therapy and global care for recurrent malignant gliomas followed until death.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cost of Illness; Cost-Benefit Analysis; Dacarbazine; Female; Glioma; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Survival Analysis; Temozolomide | 2005 |
Temozolomide plus thalidomide in patients with brain metastases from melanoma: a phase II study.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Dacarbazine; Disease-Free Survival; Female; Humans; Male; Melanoma; Middle Aged; Neoplasm Staging; Skin Neoplasms; Survival Rate; Temozolomide; Thalidomide; Treatment Outcome | 2005 |
Concomitant chemoradiotherapy followed by adjuvant temozolomide improves survival in glioblastoma multiforme.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemotherapy, Adjuvant; Combined Modality Therapy; Dacarbazine; Glioblastoma; Humans; Radiotherapy; Temozolomide; Treatment Outcome | 2005 |
Temozolomide combined with irradiation as postoperative treatment of primary glioblastoma multiforme. Phase I/II study.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Blood Cell Count; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Disease-Free Survival; Female; Glioblastoma; Humans; Male; Middle Aged; Survival Analysis; Temozolomide; Time Factors | 2005 |
Phase II study of temozolomide plus pegylated liposomal doxorubicin in the treatment of brain metastases from solid tumours.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Dacarbazine; Disease-Free Survival; Doxorubicin; Drug Administration Schedule; Female; Humans; Injections, Intravenous; Liposomes; Male; Middle Aged; Prospective Studies; Quality of Life; Temozolomide | 2006 |
Oral temozolomide in heavily pre-treated brain metastases from non-small cell lung cancer: phase II study.
Topics: Administration, Oral; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Carcinoma, Non-Small-Cell Lung; Dacarbazine; Female; Humans; Lung Neoplasms; Male; Middle Aged; Palliative Care; Temozolomide; Treatment Outcome | 2005 |
Phase I trial of irinotecan plus temozolomide in adults with recurrent malignant glioma.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Camptothecin; Dacarbazine; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Glioma; Humans; Irinotecan; Magnetic Resonance Imaging; Male; Maximum Tolerated Dose; Middle Aged; Neoplasm Recurrence, Local; Prognosis; Salvage Therapy; Survival Analysis; Temozolomide; Treatment Outcome | 2005 |
A phase II study of biochemotherapy for advanced melanoma incorporating temozolomide, decrescendo interleukin-2 and GM-CSF.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Dacarbazine; Eye Neoplasms; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Interleukin-2; Melanoma; Middle Aged; Neoplasm Metastasis; Reproducibility of Results; Skin Neoplasms; Survival Analysis; Temozolomide | 2005 |
Temozolomide with or without radiotherapy in melanoma with unresectable brain metastases.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Disease Progression; Female; Humans; Male; Melanoma; Middle Aged; Skin Neoplasms; Stereotaxic Techniques; Survival Analysis; Temozolomide; Treatment Outcome | 2006 |
Phase I study of temozolomide and lomustine in the treatment of high grade malignant glioma.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cohort Studies; Dacarbazine; Dose-Response Relationship, Drug; Female; Glioma; Humans; Lomustine; Male; Middle Aged; Temozolomide; Time Factors | 2006 |
Phase I trial of temozolomide plus O6-benzylguanine for patients with recurrent or progressive malignant glioma.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Dacarbazine; Disease Progression; Female; Glioma; Guanine; Humans; Infusions, Intravenous; Injections, Intravenous; Male; Maximum Tolerated Dose; Middle Aged; Temozolomide | 2005 |
Temozolomide after radiotherapy for newly diagnosed high-grade glioma and unfavorable low-grade glioma in children.
Topics: Adolescent; Adult; Antineoplastic Agents, Alkylating; Antineoplastic Agents, Phytogenic; Brain Neoplasms; Camptothecin; Chemotherapy, Adjuvant; Child; Child, Preschool; Combined Modality Therapy; Dacarbazine; Female; Glioma; Humans; Irinotecan; Male; Survival Analysis; Temozolomide; Treatment Outcome | 2006 |
Food and Drug Administration Drug approval summary: temozolomide plus radiation therapy for the treatment of newly diagnosed glioblastoma multiforme.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemotherapy, Adjuvant; Combined Modality Therapy; Dacarbazine; Disease Progression; Disease-Free Survival; Drug Approval; Female; Glioblastoma; Humans; Male; Middle Aged; Pneumocystis; Pneumocystis Infections; Proportional Hazards Models; Quality of Life; Radiotherapy; Salvage Therapy; Temozolomide; Time Factors; Treatment Outcome; United States; United States Food and Drug Administration | 2005 |
Perfusion and diffusion MRI of glioblastoma progression in a four-year prospective temozolomide clinical trial.
Topics: Analysis of Variance; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Diffusion Magnetic Resonance Imaging; Disease Progression; Female; Glioblastoma; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Prospective Studies; Temozolomide | 2006 |
Phase II trial of temozolomide in children with recurrent high-grade glioma.
Topics: Adolescent; Antineoplastic Agents, Alkylating; Bone Marrow; Brain Neoplasms; Child; Child, Preschool; Dacarbazine; Disease-Free Survival; Drug Administration Schedule; Female; Glioma; Humans; Male; Neoplasm Recurrence, Local; Neutropenia; Temozolomide; Thrombocytopenia; Treatment Outcome | 2006 |
Health-related quality of life in patients with glioblastoma: a randomised controlled trial.
Topics: Activities of Daily Living; Adolescent; Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Emotions; Fatigue; Female; Health Status; Humans; Male; Middle Aged; Quality of Life; Social Behavior; Stress, Psychological; Temozolomide; Treatment Outcome | 2005 |
Salvage chemotherapy with cyclophosphamide for recurrent temozolomide-refractory anaplastic astrocytoma.
Topics: Adult; Anaplasia; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Cyclophosphamide; Dacarbazine; Drug Administration Schedule; Drug Resistance, Neoplasm; Female; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Prospective Studies; Salvage Therapy; Temozolomide | 2006 |
Temozolomide in the treatment of recurrent malignant glioma in Chinese patients.
Topics: Adolescent; Adult; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Drug Administration Schedule; Female; Glioma; Hong Kong; Hospitals, Teaching; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Survival Rate; Temozolomide | 2005 |
Surgery, radiotherapy and temozolomide in treating high-grade gliomas.
Topics: Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Clinical Trials as Topic; Combined Modality Therapy; Dacarbazine; Disease Progression; Disease-Free Survival; Female; Glioblastoma; Glioma; Humans; Male; Middle Aged; Quality of Life; Radiotherapy; Temozolomide; Time Factors; Treatment Outcome | 2006 |
A biochemotherapy regimen with concurrent administration of cisplatin, vinblastine, temozolomide (Temodal), interferon-alfa and interleukin-2 for metastatic melanoma: a phase II study.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cisplatin; Dacarbazine; Disease-Free Survival; Female; Humans; Infusions, Intravenous; Interferon alpha-2; Interferon-alpha; Interleukin-2; Male; Melanoma; Middle Aged; Recombinant Proteins; Skin Neoplasms; Survival Rate; Temozolomide; Treatment Outcome; Vinblastine | 2006 |
Phase 1 study of erlotinib HCl alone and combined with temozolomide in patients with stable or recurrent malignant glioma.
Topics: Adult; Aged; Anticonvulsants; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Dacarbazine; Dose-Response Relationship, Drug; Drug Interactions; Erlotinib Hydrochloride; Female; Glioma; Humans; Male; Maximum Tolerated Dose; Middle Aged; Neoplasm Recurrence, Local; Quinazolines; Temozolomide; Treatment Outcome | 2006 |
Vinorelbine combined with a protracted course of temozolomide for recurrent brain metastases: a phase I trial.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Dacarbazine; Disease-Free Survival; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Lung Neoplasms; Lymphopenia; Male; Maximum Tolerated Dose; Middle Aged; Neutropenia; Temozolomide; Thrombocytopenia; Treatment Outcome; Vinblastine; Vinorelbine | 2006 |
Phase II trial of temozolomide plus marimastat for recurrent anaplastic gliomas: a relationship among efficacy, joint toxicity and anticonvulsant status.
Topics: Anticonvulsants; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cytochrome P-450 Enzyme System; Dacarbazine; Disease-Free Survival; Enzyme Inhibitors; Glioma; Humans; Hydroxamic Acids; Joint Diseases; Joints; Neoplasm Recurrence, Local; Survival Analysis; Temozolomide; Treatment Outcome | 2006 |
Treatment of primary glioblastoma multiforme with cetuximab, radiotherapy and temozolomide (GERT)--phase I/II trial: study protocol.
Topics: Adolescent; Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cetuximab; Combined Modality Therapy; Dacarbazine; Disease Progression; ErbB Receptors; Female; Glioblastoma; Humans; Male; Middle Aged; Survival Analysis; Temozolomide | 2006 |
Adding concomitant and adjuvant temozolomide to radiotherapy does not reduce health-related quality of life in people with glioblastoma.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemotherapy, Adjuvant; Combined Modality Therapy; Dacarbazine; Evidence-Based Medicine; Glioblastoma; Humans; Quality of Life; Temozolomide | 2006 |
Radiotherapy and temozolomide for newly diagnosed glioblastoma: recursive partitioning analysis of the EORTC 26981/22981-NCIC CE3 phase III randomized trial.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Canada; Chemotherapy, Adjuvant; Dacarbazine; Europe; Female; Glioblastoma; Humans; Male; Middle Aged; Radiotherapy, Adjuvant; Survival Analysis; Temozolomide; Treatment Outcome | 2006 |
New approach in delivering chemotherapy: locoregional treatment for recurrent glioblastoma (rGBM).
Topics: Antineoplastic Agents; Brain Neoplasms; Chemotherapy, Cancer, Regional Perfusion; Combined Modality Therapy; Dacarbazine; Disease-Free Survival; Doxorubicin; Female; Glioblastoma; Humans; Male; Middle Aged; Mitoxantrone; Neoplasm Recurrence, Local; Pilot Projects; Polyethylene Glycols; Radioimmunotherapy; Temozolomide | 2003 |
Phase II trial of temozolomide and cisplatin followed by whole brain radiotherapy in non-small-cell lung cancer patients with brain metastases: a GLOT-GFPC study.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carcinoma, Non-Small-Cell Lung; Cisplatin; Dacarbazine; Female; Humans; Lung Neoplasms; Male; Middle Aged; Temozolomide; Treatment Outcome | 2006 |
Temozolomide for recurrent or progressive high-grade malignant glioma: results of an Austrian multicenter observational study.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents, Alkylating; Austria; Brain Neoplasms; Dacarbazine; Female; Glioma; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Prognosis; Risk Assessment; Risk Factors; Survival Rate; Temozolomide; Treatment Outcome | 2006 |
MR-guided laser-induced interstitial thermotherapy of recurrent glioblastoma multiforme: preliminary results in 16 patients.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Disease-Free Survival; Feasibility Studies; Female; Glioblastoma; Humans; Laser Coagulation; Magnetic Resonance Imaging; Male; Middle Aged; Neoplasm Recurrence, Local; Temozolomide; Temperature | 2006 |
Temozolomide treatment for newly diagnosed anaplastic oligodendrogliomas: a clinical efficacy trial.
Topics: Adult; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Disease-Free Survival; Drug Administration Schedule; Female; Humans; Male; Middle Aged; Oligodendroglioma; Temozolomide; Treatment Outcome | 2006 |
Temozolomide chemotherapy in patients with recurrent malignant gliomas.
Topics: Administration, Oral; Adolescent; Adult; Antineoplastic Agents, Alkylating; Brain; Brain Neoplasms; Chemical and Drug Induced Liver Injury; Combined Modality Therapy; Dacarbazine; Drug Administration Schedule; Female; Glioma; Humans; Leukopenia; Magnetic Resonance Imaging; Male; Middle Aged; Nausea; Neoplasm Recurrence, Local; Survival Analysis; Temozolomide; Treatment Outcome; Vomiting | 2006 |
Safety and pharmacokinetics of temozolomide using a dose-escalation, metronomic schedule in recurrent paediatric brain tumours.
Topics: Administration, Oral; Antineoplastic Agents, Alkylating; Brain Neoplasms; Child; Dacarbazine; Dose-Response Relationship, Drug; Drug Administration Schedule; Feasibility Studies; Female; Humans; Male; Neoplasm Recurrence, Local; Temozolomide | 2006 |
Phase I study of capecitabine in combination with temozolomide in the treatment of patients with brain metastases from breast carcinoma.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Breast Neoplasms; Capecitabine; Cohort Studies; Dacarbazine; Deoxycytidine; Dose-Response Relationship, Drug; Drug Administration Schedule; Fatigue; Female; Fluorouracil; Humans; Middle Aged; Nausea; Temozolomide; Treatment Outcome; Vomiting | 2006 |
Early necrosis following concurrent Temodar and radiotherapy in patients with glioblastoma.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemotherapy, Adjuvant; Combined Modality Therapy; Dacarbazine; Female; Glioblastoma; Humans; Male; Middle Aged; Necrosis; Radiation-Sensitizing Agents; Radiotherapy Dosage; Temozolomide; Treatment Outcome | 2007 |
Correlations between O6-methylguanine DNA methyltransferase promoter methylation status, 1p and 19q deletions, and response to temozolomide in anaplastic and recurrent oligodendroglioma: a prospective GICNO study.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chromosome Deletion; Chromosomes, Human, Pair 1; Chromosomes, Human, Pair 19; Dacarbazine; DNA Methylation; DNA Repair; Female; Humans; In Situ Hybridization, Fluorescence; Male; Middle Aged; Neoplasm Recurrence, Local; O(6)-Methylguanine-DNA Methyltransferase; Oligodendroglioma; Promoter Regions, Genetic; Temozolomide; Treatment Outcome | 2006 |
[Efficacy and safety of monotherapy with temozolomide in patients with anaplastic astrocytoma at first relapse--a phase II clinical study].
Topics: Adult; Aged; Anorexia; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Dacarbazine; Disease-Free Survival; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Leukopenia; Male; Middle Aged; Temozolomide | 2006 |
Temozolomide in combination with celecoxib in patients with advanced melanoma. A phase II study of the Hellenic Cooperative Oncology Group.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Celecoxib; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dacarbazine; Female; Humans; Immunohistochemistry; Male; Melanoma; Middle Aged; Neoplasm Metastasis; Pyrazoles; Skin Neoplasms; Sulfonamides; Survival Analysis; Temozolomide | 2006 |
Phase II trial of lomustine plus temozolomide chemotherapy in addition to radiotherapy in newly diagnosed glioblastoma: UKT-03.
Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Chemotherapy, Adjuvant; Dacarbazine; Disease-Free Survival; DNA Methylation; Drug Administration Schedule; Female; Glioblastoma; Humans; Lomustine; Male; Middle Aged; O(6)-Methylguanine-DNA Methyltransferase; Predictive Value of Tests; Prognosis; Promoter Regions, Genetic; Radiotherapy, Adjuvant; Survival Analysis; Temozolomide; Treatment Outcome | 2006 |
Phase II study of temozolomide and thalidomide in patients with metastatic melanoma in the brain: high rate of thromboembolic events (CALGB 500102).
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Dacarbazine; Humans; Melanoma; Middle Aged; Pulmonary Embolism; Skin Neoplasms; Survival Rate; Temozolomide; Thalidomide; Treatment Failure; Venous Thrombosis; Withholding Treatment | 2006 |
Dose-intensified bi-weekly temozolomide in patients with asymptomatic brain metastases from malignant melanoma: a phase II DeCOG/ADO study.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Male; Melanoma; Middle Aged; Skin Neoplasms; Survival Analysis; Temozolomide; Treatment Outcome | 2006 |
A pilot study of metronomic temozolomide treatment in patients with recurrent temozolomide-refractory glioblastoma.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Resistance, Neoplasm; Female; Glioblastoma; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Pilot Projects; Temozolomide | 2006 |
Temozolomide 3 weeks on and 1 week off as first-line therapy for recurrent glioblastoma: phase II study from gruppo italiano cooperativo di neuro-oncologia (GICNO).
Topics: Adult; Aged; Anemia; Antineoplastic Agents, Alkylating; Brain Neoplasms; Constipation; Dacarbazine; Disease Progression; DNA Methylation; Drug Administration Schedule; Female; Glioblastoma; Humans; Lymphopenia; Male; Middle Aged; Neoplasm Recurrence, Local; O(6)-Methylguanine-DNA Methyltransferase; Survival Analysis; Temozolomide; Treatment Outcome | 2006 |
Administration of temozolomide during and after radiotherapy for newly diagnosed high-grade gliomas excluding glioblastoma multiforme.
Topics: Antineoplastic Agents; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Glioma; Humans; Survival Analysis; Temozolomide | 2007 |
A North American brain tumor consortium (NABTC 99-04) phase II trial of temozolomide plus thalidomide for recurrent glioblastoma multiforme.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Dacarbazine; Disease-Free Survival; Enzyme-Linked Immunosorbent Assay; Female; Glioblastoma; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; North America; Survival Analysis; Temozolomide; Thalidomide | 2007 |
A phase I/II study of lomustine and temozolomide in patients with cerebral metastases from malignant melanoma.
Topics: Administration, Oral; Adult; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Dacarbazine; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Lomustine; Male; Maximum Tolerated Dose; Melanoma; Middle Aged; Neutropenia; Temozolomide; Thrombocytopenia; Treatment Failure | 2007 |
[Temozolomide in the treatment of recurrent malignant glioma].
Topics: Administration, Oral; Adolescent; Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Drug Administration Schedule; Female; Glioma; Humans; Leukopenia; Magnetic Resonance Imaging; Male; Middle Aged; Neoplasm Recurrence, Local; Prospective Studies; Temozolomide | 2006 |
MGMT methylation: a marker of response to temozolomide in low-grade gliomas.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Biomarkers, Tumor; Brain Neoplasms; Dacarbazine; Disease Progression; DNA Methylation; DNA Modification Methylases; DNA Mutational Analysis; DNA Repair Enzymes; Female; Genetic Markers; Glioma; Humans; Male; Middle Aged; Neoadjuvant Therapy; Predictive Value of Tests; Prognosis; Promoter Regions, Genetic; Survival Rate; Temozolomide; Tumor Suppressor Protein p14ARF; Tumor Suppressor Proteins | 2006 |
Concomitant treatment of brain metastasis with whole brain radiotherapy [WBRT] and temozolomide [TMZ] is active and improves quality of life.
Topics: Aged; Brain; Brain Neoplasms; Combined Modality Therapy; Cranial Irradiation; Dacarbazine; Female; Humans; Male; Middle Aged; Prospective Studies; Quality of Life; Survival Rate; Temozolomide | 2007 |
Estimation of radiobiologic parameters and equivalent radiation dose of cytotoxic chemotherapy in malignant glioma.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Division; Dacarbazine; Glioma; Humans; Monte Carlo Method; Radiobiology; Relative Biological Effectiveness; Temozolomide; Therapeutic Equivalency | 2007 |
Safety and feasibility of long-term temozolomide treatment in patients with high-grade glioma.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Disease-Free Survival; Feasibility Studies; Female; Glioma; Humans; Longitudinal Studies; Male; Middle Aged; Risk Assessment; Risk Factors; Survival Analysis; Survival Rate; Temozolomide; Treatment Outcome | 2007 |
Temozolomide as salvage treatment in primary brain lymphomas.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Female; Humans; Lymphoma; Male; Middle Aged; Neoplasm Recurrence, Local; Salvage Therapy; Temozolomide | 2007 |
Temozolomide in children with progressive low-grade glioma.
Topics: Adolescent; Antineoplastic Agents, Alkylating; Brain Neoplasms; Child; Child, Preschool; Dacarbazine; Drug Administration Schedule; Female; Glioma; Humans; Male; Survival Analysis; Survivors; Temozolomide; Time Factors; Treatment Outcome | 2007 |
Temozolomide in glioblastoma: results of administration at first relapse and in newly diagnosed cases. Is still proposable an alternative schedule to concomitant protocol?
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Disease-Free Survival; Drug Administration Schedule; Female; Glioblastoma; Humans; Karnofsky Performance Status; Male; Middle Aged; Neoplasm Recurrence, Local; Statistics, Nonparametric; Temozolomide; Time Factors; Treatment Outcome | 2007 |
Phase II trial of temozolomide and irinotecan as second-line treatment for advanced non-small cell lung cancer.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Camptothecin; Carcinoma, Non-Small-Cell Lung; Dacarbazine; Disease-Free Survival; Female; Humans; Irinotecan; Lung Neoplasms; Male; Middle Aged; Neoplasm Recurrence, Local; Survival Analysis; Temozolomide | 2006 |
Correlation between O6-methylguanine-DNA methyltransferase and survival in inoperable newly diagnosed glioblastoma patients treated with neoadjuvant temozolomide.
Topics: Adolescent; Adult; Aged; Biomarkers, Tumor; Brain Neoplasms; Chemotherapy, Adjuvant; Dacarbazine; Dose-Response Relationship, Drug; Drug Administration Schedule; Follow-Up Studies; Glioblastoma; Humans; Magnetic Resonance Imaging; Maximum Tolerated Dose; Middle Aged; Neoplasm Staging; O(6)-Methylguanine-DNA Methyltransferase; Probability; Prospective Studies; Risk Assessment; Survival Analysis; Temozolomide; Treatment Outcome | 2007 |
Salvage chemotherapy with procarbazine and fotemustine combination in the treatment of temozolomide treated recurrent glioblastoma patients.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Dacarbazine; Disease-Free Survival; Female; Glioblastoma; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Neoplasm Recurrence, Local; Nitrosourea Compounds; Organophosphorus Compounds; Procarbazine; Salvage Therapy; Temozolomide | 2008 |
Phase II study of temozolomide and concomitant whole-brain radiotherapy in patients with brain metastases from solid tumors.
Topics: Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Small Cell; Chemotherapy, Adjuvant; Clinical Trials, Phase II as Topic; Combined Modality Therapy; Cranial Irradiation; Dacarbazine; Female; Humans; Lung Neoplasms; Male; Melanoma; Middle Aged; Mouth Neoplasms; Neoplasms, Unknown Primary; Palliative Care; Rectal Neoplasms; Research Design; Temozolomide; Treatment Outcome | 2007 |
Efficacy and tolerability of temozolomide in an alternating weekly regimen in patients with recurrent glioma.
Topics: Adult; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Disease Progression; DNA Methylation; Drug Administration Schedule; Female; Glioma; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Neoplasm Recurrence, Local; Polymerase Chain Reaction; Prospective Studies; Survival Analysis; Temozolomide; Treatment Outcome | 2007 |
Phase-1 trial of gefitinib and temozolomide in patients with malignant glioma: a North American brain tumor consortium study.
Topics: Adrenal Cortex Hormones; Adult; Aged; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Brain Edema; Brain Neoplasms; Dacarbazine; Dose-Response Relationship, Drug; Female; Gefitinib; Glioblastoma; Glioma; Humans; Karnofsky Performance Status; Male; Middle Aged; Quinazolines; Temozolomide | 2008 |
Phase 2 study of temozolomide in children and adolescents with recurrent central nervous system tumors: a report from the Children's Oncology Group.
Topics: Administration, Oral; Adolescent; Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Central Nervous System Neoplasms; Child; Child, Preschool; Dacarbazine; Drug Administration Schedule; Ependymoma; Female; Humans; Infant; Male; Medulloblastoma; Neoplasm Recurrence, Local; Neuroectodermal Tumors, Primitive; Temozolomide; Treatment Outcome | 2007 |
A phase II trial of vinorelbine and intensive temozolomide for patients with recurrent or progressive brain metastases.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Dacarbazine; Disease-Free Survival; Female; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Neoplasm Recurrence, Local; Survival Analysis; Temozolomide; Vinblastine; Vinorelbine | 2008 |
Phase I trial of single-dose temozolomide and continuous administration of o6-benzylguanine in children with brain tumors: a pediatric brain tumor consortium report.
Topics: Adolescent; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Child; Child, Preschool; Dacarbazine; Enzyme Inhibitors; Female; Guanine; Humans; Infant; Male; Temozolomide; Treatment Outcome | 2007 |
Pilot trial of the rate of response, safety, and tolerability of temozolomide and oral VP-16 in patients with recurrent or treatment-induced malignant central nervous system tumors.
Topics: Administration, Oral; Adolescent; Adult; Aged; Antineoplastic Agents; Brain Neoplasms; Dacarbazine; Drug Therapy, Combination; Etoposide; Female; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Neoplasms, Neuroepithelial; Neoplasms, Second Primary; Pilot Projects; Temozolomide; Treatment Outcome | 2008 |
Phase I study of temozolomide and irinotecan for recurrent malignant gliomas in patients receiving enzyme-inducing antiepileptic drugs: a north american brain tumor consortium study.
Topics: Adult; Aged; Anticonvulsants; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Camptothecin; Dacarbazine; Drug Administration Schedule; Drug Interactions; Enzyme Induction; Female; Glioma; Humans; Irinotecan; Male; Middle Aged; Neoplasm Recurrence, Local; Temozolomide | 2007 |
Convection-enhanced delivery of cintredekin besudotox (interleukin-13-PE38QQR) followed by radiation therapy with and without temozolomide in newly diagnosed malignant gliomas: phase 1 study of final safety results.
Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Chemotherapy, Adjuvant; Dacarbazine; Dose-Response Relationship, Drug; Drug Delivery Systems; Exotoxins; Female; Glioma; Humans; Infusions, Intralesional; Interleukin-13; Male; Middle Aged; Nervous System Diseases; Radiotherapy, Conformal; Recombinant Fusion Proteins; Temozolomide; Treatment Outcome | 2007 |
Cost-effectiveness of temozolomide for the treatment of newly diagnosed glioblastoma multiforme: a report from the EORTC 26981/22981 NCI-C CE3 Intergroup Study.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cost-Benefit Analysis; Dacarbazine; Disease-Free Survival; Follow-Up Studies; Glioblastoma; Health Care Costs; Humans; Middle Aged; Quality-Adjusted Life Years; Survival Rate; Temozolomide | 2008 |
Multi-institutional phase II study of temozolomide administered twice daily in the treatment of recurrent high-grade gliomas.
Topics: Administration, Oral; Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Drug Administration Schedule; Drug Evaluation; Female; Glioma; Humans; Male; Middle Aged; Prognosis; Temozolomide | 2008 |
Radiochemotherapy in patients with primary glioblastoma comparing two temozolomide dose regimens.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Germany; Glioblastoma; Humans; Male; Middle Aged; Prevalence; Radiotherapy; Risk Assessment; Risk Factors; Survival Analysis; Survival Rate; Temozolomide; Treatment Outcome | 2008 |
Preliminary results from a phase I/II study of perillyl alcohol intranasal administration in adults with recurrent malignant gliomas.
Topics: Administration, Intranasal; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Blood-Brain Barrier; Brain Neoplasms; Dacarbazine; Disease Progression; Drug Administration Schedule; Enzyme Inhibitors; Female; Glioma; Humans; Magnetic Resonance Imaging; Male; Monoterpenes; Neoplasm Recurrence, Local; Oncogene Protein p21(ras); Signal Transduction; Survival Rate; Temozolomide; Transforming Growth Factor beta; Treatment Outcome | 2008 |
Low-dose chemotherapy in combination with COX-2 inhibitors and PPAR-gamma agonists in recurrent high-grade gliomas - a phase II study.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Brain Neoplasms; Capecitabine; Cyclooxygenase 2 Inhibitors; Dacarbazine; Deoxycytidine; Drug Administration Schedule; Edema; Efferent Pathways; Erythema; Female; Fluorouracil; Gene Expression Regulation, Neoplastic; Glioblastoma; Glioma; Humans; Immunohistochemistry; Lactones; Male; Middle Aged; Neoplasm Recurrence, Local; Neovascularization, Pathologic; Pioglitazone; PPAR gamma; Predictive Value of Tests; Quality of Life; Sulfones; Temozolomide; Thiazolidinediones; Treatment Outcome | 2007 |
Phase II trial of arsenic trioxide and ascorbic acid with temozolomide in patients with metastatic melanoma with or without central nervous system metastases.
Topics: Adult; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Antioxidants; Arsenic Trioxide; Arsenicals; Ascorbic Acid; Brain Neoplasms; Dacarbazine; Female; Humans; Male; Melanoma; Middle Aged; Oxides; Skin Neoplasms; Temozolomide | 2008 |
Phase II pilot study of bevacizumab in combination with temozolomide and regional radiation therapy for up-front treatment of patients with newly diagnosed glioblastoma multiforme: interim analysis of safety and tolerability.
Topics: Adult; Aged; Angiogenesis Inhibitors; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents, Alkylating; Bevacizumab; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Drug Administration Schedule; Drug Therapy, Combination; Female; Glioblastoma; Humans; Male; Middle Aged; Pilot Projects; Temozolomide | 2008 |
Safety and pharmacokinetics of dose-intensive imatinib mesylate plus temozolomide: phase 1 trial in adults with malignant glioma.
Topics: Adult; Aged; Anticonvulsants; Antineoplastic Combined Chemotherapy Protocols; Benzamides; Brain Neoplasms; Dacarbazine; Female; Glioma; Humans; Imatinib Mesylate; Kaplan-Meier Estimate; Male; Maximum Tolerated Dose; Middle Aged; Piperazines; Proto-Oncogene Mas; Pyrimidines; Temozolomide | 2008 |
Salvage chemotherapy with CPT-11 for recurrent temozolomide-refractory anaplastic astrocytoma.
Topics: Adolescent; Adult; Antineoplastic Agents; Astrocytoma; Brain Neoplasms; Camptothecin; Dacarbazine; Female; Humans; Irinotecan; Male; Middle Aged; Neoplasm Recurrence, Local; Prospective Studies; Salvage Therapy; Temozolomide | 2008 |
Phase II study of temozolomide, thalidomide, and celecoxib for newly diagnosed glioblastoma in adults.
Topics: Adult; Aged; Angiogenesis Inhibitors; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Celecoxib; Dacarbazine; Disease-Free Survival; DNA Methylation; Endostatins; Female; Fibroblast Growth Factor 2; Glioblastoma; Humans; Kaplan-Meier Estimate; Male; Middle Aged; O(6)-Methylguanine-DNA Methyltransferase; Polymerase Chain Reaction; Promoter Regions, Genetic; Pyrazoles; Sulfonamides; Temozolomide; Thalidomide; Thrombospondins; Vascular Endothelial Growth Factor A | 2008 |
Temozolomide three weeks on and one week off as first line therapy for patients with recurrent or progressive low grade gliomas.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chromosomes, Human, Pair 1; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Glioma; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Neoplasm Recurrence, Local; Survival Analysis; Temozolomide; Tumor Suppressor Proteins | 2008 |
Radiochemotherapy with temozolomide as re-irradiation using high precision fractionated stereotactic radiotherapy (FSRT) in patients with recurrent gliomas.
Topics: Adolescent; Adult; Antineoplastic Agents, Alkylating; Brain Neoplasms; Child; Combined Modality Therapy; Dacarbazine; Female; Follow-Up Studies; Glioma; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Neoplasm Recurrence, Local; Radiotherapy; Survival Analysis; Temozolomide | 2008 |
CPT-11 for recurrent temozolomide-refractory 1p19q co-deleted anaplastic oligodendroglioma.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Antineoplastic Agents, Phytogenic; Brain Neoplasms; Camptothecin; Chromosome Deletion; Chromosomes, Human, Pair 1; Dacarbazine; Female; Humans; Irinotecan; Male; Middle Aged; Neoplasm Recurrence, Local; Oligodendroglioma; Survival Analysis; Temozolomide | 2008 |
A phase I trial of temozolomide and lomustine in newly diagnosed high-grade gliomas of childhood.
Topics: Adolescent; Adult; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Child; Child, Preschool; Dacarbazine; Glioma; Humans; Lomustine; Maximum Tolerated Dose; Temozolomide | 2008 |
Comparison of postoperative radiotherapy and combined postoperative radiotherapy and chemotherapy in the multidisciplinary management of malignant gliomas. A joint Radiation Therapy Oncology Group and Eastern Cooperative Oncology Group study.
Topics: Adult; Age Factors; Antineoplastic Agents; Astrocytoma; Brain Neoplasms; Carmustine; Clinical Trials as Topic; Dacarbazine; Drug Therapy, Combination; Female; Glioma; Humans; Male; Middle Aged; Prednisone; Probability; Prognosis; Radiotherapy Dosage; Random Allocation; Semustine | 1983 |
Controlled study with imidazole carboxamide (DTIC), DTIC + bacillus Calmette-Guérin (BCG), and DTIC + corynebacterium parvum in advanced malignant melanoma. W.H.O. Collaborating Centres for Evaluation of Methods of Diagnosis and Treatment of Melanoma.
Topics: Bacterial Vaccines; BCG Vaccine; Brain Neoplasms; Clinical Trials as Topic; Combined Modality Therapy; Dacarbazine; Female; Fever; Humans; Leukopenia; Male; Melanoma; Middle Aged; Nausea; Propionibacterium acnes; Sex Factors; Time Factors | 1984 |
A phase II study of the sequential administration of dacarbazine and fotemustine in the treatment of cerebral metastases from malignant melanoma.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Dacarbazine; Drug Administration Schedule; Female; Humans; Leukopenia; Male; Melanoma; Middle Aged; Nitrosourea Compounds; Organophosphorus Compounds; Thrombocytopenia; Treatment Outcome | 1994 |
Evaluation of cisplatin and DTIC in inoperable stage III and IV melanoma. A Southwest Oncology Group study.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cisplatin; Dacarbazine; Female; Humans; Male; Melanoma; Middle Aged; Neoplasm Staging; Survival Analysis | 1993 |
Temozolomide: a new oral cytotoxic chemotherapeutic agent with promising activity against primary brain tumours.
Topics: Administration, Oral; Antineoplastic Agents; Astrocytoma; Brain; Brain Neoplasms; Dacarbazine; Dose-Response Relationship, Drug; Humans; Temozolomide; Tomography, X-Ray Computed | 1993 |
Ototoxicity in children with malignant brain tumors treated with the "8 in 1" chemotherapy protocol.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Chemotherapy, Adjuvant; Child; Child, Preschool; Cisplatin; Combined Modality Therapy; Cyclophosphamide; Cytarabine; Dacarbazine; Drug Administration Schedule; Evaluation Studies as Topic; Female; Follow-Up Studies; Hearing Loss; Humans; Hydroxyurea; Incidence; Infant; Lomustine; Male; Methylprednisolone; Procarbazine; Radiation Injuries; Risk Factors; Vincristine | 1996 |
The Charing Cross Hospital experience with temozolomide in patients with gliomas.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Female; Glioma; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Survival Rate; Temozolomide; Tomography, X-Ray Computed | 1996 |
Chemoimmunotherapy with bleomycin, vincristine, lomustine, dacarbazine (BOLD) plus interferon alpha for metastatic melanoma: a multicentre phase II study.
Topics: Abdominal Neoplasms; Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Brain Neoplasms; Dacarbazine; Female; Humans; Immunotherapy; Interferon-alpha; Lomustine; Male; Melanoma; Middle Aged; Neoplasm Staging; Skin Neoplasms; Treatment Outcome; Vincristine | 1997 |
Multicentre CRC phase II trial of temozolomide in recurrent or progressive high-grade glioma.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Female; Glioma; Humans; Male; Middle Aged; Temozolomide | 1997 |
Combined treatment with dacarbazine, cisplatin, fotemustine and tamoxifen in metastatic malignant melanoma.
Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cisplatin; Dacarbazine; Humans; Melanoma; Middle Aged; Neoplasm Metastasis; Nitrosourea Compounds; Organophosphorus Compounds; Skin Neoplasms; Survival Rate; Tamoxifen | 1998 |
Phase I trial of temozolomide using an extended continuous oral schedule.
Topics: Administration, Oral; Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Calibration; Chromatography, High Pressure Liquid; Dacarbazine; Drug Administration Schedule; England; Female; Glioma; Humans; Male; Metabolic Clearance Rate; Middle Aged; Neoplasms; Temozolomide | 1998 |
Pharmacokinetics of temozolomide in association with fotemustine in malignant melanoma and malignant glioma patients: comparison of oral, intravenous, and hepatic intra-arterial administration.
Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Blood-Brain Barrier; Brain Neoplasms; Dacarbazine; Female; Glioma; Hepatic Artery; Humans; Infusions, Intra-Arterial; Infusions, Intravenous; Male; Melanoma; Middle Aged; Nitrosourea Compounds; Organophosphorus Compounds; Temozolomide | 1998 |
Long-term outcome of treatment with dacarbazine, cisplatin, interferon-alpha and intravenous high dose interleukin-2 in poor risk melanoma patients.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cisplatin; Dacarbazine; Humans; Interferon-alpha; Interleukin-2; L-Lactate Dehydrogenase; Melanoma; Middle Aged; Neoplasm Metastasis; Prognosis; Risk; Skin Neoplasms; Survival Rate; Time Factors; Treatment Outcome | 1998 |
Sequential administration of temozolomide and fotemustine: depletion of O6-alkyl guanine-DNA transferase in blood lymphocytes and in tumours.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Dacarbazine; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Resistance, Neoplasm; Female; Glioma; Humans; Lymphocytes; Male; Melanoma; Middle Aged; Nitrosourea Compounds; O(6)-Methylguanine-DNA Methyltransferase; Organophosphorus Compounds; Temozolomide | 1999 |
Multicenter phase II trial of temozolomide in patients with anaplastic astrocytoma or anaplastic oligoastrocytoma at first relapse. Temodal Brain Tumor Group.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Dacarbazine; Female; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Prognosis; Proportional Hazards Models; Quality of Life; Survival Analysis; Temozolomide | 1999 |
Phase I dose-escalation and pharmacokinetic study of temozolomide (SCH 52365) for refractory or relapsing malignancies.
Topics: Administration, Oral; Adult; Aged; Antineoplastic Agents, Alkylating; Biological Availability; Brain Neoplasms; Dacarbazine; Dose-Response Relationship, Drug; Eating; Female; Glioma; Humans; Male; Melanoma; Middle Aged; Neoplasms; Skin Neoplasms; Temozolomide; Treatment Outcome | 1999 |
Early evaluation of tumour metabolic response using [18F]fluorodeoxyglucose and positron emission tomography: a pilot study following the phase II chemotherapy schedule for temozolomide in recurrent high-grade gliomas.
Topics: Adult; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Evaluation Studies as Topic; Female; Fluorodeoxyglucose F18; Glioma; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Pilot Projects; Radiopharmaceuticals; Temozolomide; Tomography, Emission-Computed | 2000 |
Health-related quality of life in patients treated with temozolomide versus procarbazine for recurrent glioblastoma multiforme.
Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Disease Progression; Female; Glioblastoma; Health Status; Humans; Male; Middle Aged; Procarbazine; Quality of Life; Temozolomide | 2000 |
A phase II study of biochemotherapy for the treatment of metastatic malignant melanoma.
Topics: Abdominal Neoplasms; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cisplatin; Colorado; Combined Modality Therapy; Dacarbazine; Female; Follow-Up Studies; Humans; Hypotension; Immunologic Factors; Interferon alpha-2; Interferon-alpha; Interleukin-2; Life Tables; Liver Neoplasms; Lung Neoplasms; Male; Melanoma; Middle Aged; Neutropenia; Recombinant Proteins; Remission Induction; Survival Analysis; Tomography, X-Ray Computed; Treatment Outcome; Vinblastine | 2000 |
A phase II study of temozolomide vs. procarbazine in patients with glioblastoma multiforme at first relapse.
Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Disease-Free Survival; Female; Glioblastoma; Gliosarcoma; Humans; Male; Middle Aged; Procarbazine; Prognosis; Quality of Life; Recurrence; Temozolomide; Time Factors | 2000 |
Health-related quality of life in patients with anaplastic astrocytoma during treatment with temozolomide.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Dacarbazine; Disease Progression; Female; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Quality of Life; Survival Analysis; Temozolomide; Treatment Failure | 2000 |
A randomized phase II and pharmacokinetic study of dacarbazine in patients with recurrent glioma.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Drug Administration Schedule; Female; Glioma; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Survival Analysis; Treatment Outcome | 2000 |
Phase II study of temozolomide in heavily pretreated cancer patients with brain metastases.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Drug Evaluation; Female; Humans; Male; Middle Aged; Safety; Temozolomide; Treatment Outcome | 2001 |
Temozolomide as a second-line systemic regimen in recurrent high-grade glioma: a phase II study.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Disease Progression; Disease-Free Survival; Dose-Response Relationship, Drug; Female; Glioma; Humans; Male; Middle Aged; Multivariate Analysis; Neoplasm Recurrence, Local; Survival Analysis; Survival Rate; Temozolomide | 2001 |
Multicenter phase II trial of temozolomide in patients with glioblastoma multiforme at first relapse.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Disease-Free Survival; Female; Glioblastoma; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Prognosis; Quality of Life; Temozolomide | 2001 |
A phase I trial of 1,3-bis(2-chloroethyl)-1-nitrosourea plus temozolomide: a North American Brain Tumor Consortium study.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Carmustine; Dacarbazine; Dose-Response Relationship, Drug; Half-Life; Humans; Maximum Tolerated Dose; Temozolomide | 2000 |
Safety and efficacy of temozolomide in patients with recurrent anaplastic oligodendrogliomas after standard radiotherapy and chemotherapy.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Dacarbazine; Humans; Middle Aged; Neoplasm Recurrence, Local; Oligodendroglioma; Temozolomide | 2001 |
A phase II trial of temozolomide for patients with recurrent or progressive brain metastases.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Carcinoma, Non-Small-Cell Lung; Dacarbazine; Disease Progression; Female; Humans; Lung Neoplasms; Magnetic Resonance Imaging; Male; Middle Aged; Neoplasm Recurrence, Local; Survival Analysis; Temozolomide; Tomography, X-Ray Computed | 2001 |
A phase II study of extended low-dose temozolomide in recurrent malignant gliomas.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Dose-Response Relationship, Drug; Female; Glioma; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Prospective Studies; Survival Analysis; Temozolomide; Treatment Outcome | 2002 |
Temozolomide in combination with docetaxel in patients with advanced melanoma: a phase II study of the Hellenic Cooperative Oncology Group.
Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Dacarbazine; Disease-Free Survival; Docetaxel; Female; Humans; Infusions, Intravenous; Male; Melanoma; Middle Aged; Neutropenia; Paclitaxel; Skin Neoplasms; Taxoids; Temozolomide; Thrombocytopenia | 2002 |
Promising survival for patients with newly diagnosed glioblastoma multiforme treated with concomitant radiation plus temozolomide followed by adjuvant temozolomide.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemotherapy, Adjuvant; Combined Modality Therapy; Dacarbazine; Drug Administration Schedule; Female; Glioblastoma; Humans; Male; Middle Aged; Pneumocystis Infections; Temozolomide | 2002 |
Phase II trial of temozolomide plus the matrix metalloproteinase inhibitor, marimastat, in recurrent and progressive glioblastoma multiforme.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Dacarbazine; Disease-Free Survival; Drug Administration Schedule; Enzyme Inhibitors; Female; Glioblastoma; Humans; Hydroxamic Acids; Male; Middle Aged; Neoplasm Recurrence, Local; Temozolomide | 2002 |
Effect of temozolomide on central nervous system relapse in patients with advanced melanoma.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Case-Control Studies; Dacarbazine; Female; Humans; Lung Neoplasms; Male; Melanoma; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Staging; Retrospective Studies; Soft Tissue Neoplasms; Survival Rate; Temozolomide; Treatment Outcome | 2002 |
Temozolomide and whole brain irradiation in melanoma metastatic to the brain: a phase II trial of the Cytokine Working Group.
Topics: Administration, Oral; Adult; Antineoplastic Agents, Alkylating; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Disease-Free Survival; Dose Fractionation, Radiation; Female; Humans; Male; Melanoma; Middle Aged; Skin Neoplasms; Temozolomide; Treatment Outcome | 2002 |
Concomitant radiotherapy and metronomic temozolomide in pediatric high-risk brain tumors.
Topics: Adolescent; Antineoplastic Agents, Alkylating; Bone Marrow; Brain Neoplasms; Child; Combined Modality Therapy; Dacarbazine; Female; Humans; Male; Pilot Projects; Radiotherapy Dosage; Temozolomide | 2002 |
Results with methyl-CCNU and DTIC in metastatic melanoma.
Topics: Brain Neoplasms; Chemical and Drug Induced Liver Injury; Clinical Trials as Topic; Dacarbazine; Drug Therapy, Combination; Female; Humans; Liver Neoplasms; Male; Melanoma; Neoplasm Metastasis; Nitrosourea Compounds; Prognosis; Remission, Spontaneous; Semustine; Thrombocytopenia; Time Factors; Triazenes | 1977 |
Comparative evaluation of three combination regimens for advanced malignant melanoma: results of an international cooperative study.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Brain Neoplasms; Carmustine; Central Nervous System Diseases; Dacarbazine; Dactinomycin; Drug Therapy, Combination; Female; Humans; Male; Melanoma; Middle Aged; Neoplasm Metastasis; Remission, Spontaneous; Vincristine | 1976 |
Fotemustine--an advance in the treatment of metastatic malignant melanoma.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Dacarbazine; Female; Humans; Male; Melanoma; Middle Aged; Nitrosourea Compounds; Organophosphorus Compounds; Skin Neoplasms | 1992 |
Our experience with interferon alpha: metastatic malignant melanoma.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Dacarbazine; Female; Humans; Interferon-alpha; Interleukin-2; Male; Melanoma; Middle Aged | 1992 |
Fotemustine: an overview of its clinical activity in disseminated malignant melanoma.
Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Dacarbazine; Humans; Immunologic Factors; Interferon alpha-2; Interferon-alpha; Lung Neoplasms; Melanoma; Nitrosourea Compounds; Organophosphorus Compounds; Recombinant Proteins; Remission Induction; Vindesine | 1992 |
In vivo depletion of O6-alkylguanine-DNA-alkyltransferase in lymphocytes and melanoma of patients treated with CB 10-277, a new DTIC analogue.
Topics: Adult; Aged; Antineoplastic Agents; Brain Neoplasms; Dacarbazine; Female; Humans; Liver Neoplasms; Lung Neoplasms; Lymphatic Metastasis; Lymphocytes; Male; Melanoma; Methyltransferases; Middle Aged; O(6)-Methylguanine-DNA Methyltransferase; Skin Neoplasms; Triazenes | 1992 |
Response to mesna, doxorubicin, ifosfamide, and dacarbazine in 108 patients with metastatic or unresectable sarcoma and no prior chemotherapy.
Topics: Actuarial Analysis; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Brain Neoplasms; Clinical Trials as Topic; Dacarbazine; Doxorubicin; Drug Administration Schedule; Drug Evaluation; Female; Humans; Ifosfamide; Male; Mesna; Middle Aged; Remission Induction; Sarcoma; Soft Tissue Neoplasms; Spinal Cord Neoplasms | 1989 |
Randomized comparisons of radiotherapy and carmustine versus procarbazine versus dacarbazine for the treatment of malignant gliomas following surgery: a Southwest Oncology Group Study.
Topics: Brain Neoplasms; Carmustine; Combined Modality Therapy; Dacarbazine; Female; Follow-Up Studies; Glioblastoma; Humans; Male; Procarbazine | 1986 |
Doxorubicin, ifosfamide, and dacarbazine (AID) with mesna uroprotection for advanced untreated sarcoma: a phase I study.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Dacarbazine; Doxorubicin; Drug Evaluation; Female; Humans; Ifosfamide; Male; Mesna; Middle Aged; Sarcoma | 1986 |
1578 other study(ies) available for dacarbazine and Brain Neoplasms
| Article | Year |
|---|---|
1-Aryl-3,3-dimethyltriazenes: potential central nervous system active analogues of 5-(3,3-dimethyl-1-triazeno)imidazole-4-carboxamide (DTIC).
Topics: Animals; Antineoplastic Agents; Blood-Brain Barrier; Brain Neoplasms; Dacarbazine; Drug Evaluation, Preclinical; Ependymoma; Leukemia L1210; Melanoma; Mice; Mice, Inbred Strains; Structure-Activity Relationship | 1984 |
Temozolomide is additive with cytotoxic effect of irradiation in canine glioma cell lines.
Topics: Animals; Brain Neoplasms; Cell Line; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; Dog Diseases; Dogs; Glioma; Humans; Temozolomide; Tumor Suppressor Proteins | 2021 |
Effect of long-term adjuvant temozolomide chemotherapy on primary glioblastoma patient survival.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemotherapy, Adjuvant; Dacarbazine; Glioblastoma; Humans; Quality of Life; Retrospective Studies; Temozolomide | 2021 |
Dramatic clinical response in the treatment of small cell glioblastoma multiforme.
Topics: Brain Neoplasms; Dacarbazine; DNA Methylation; Female; Glioblastoma; Humans; Middle Aged; O(6)-Methylguanine-DNA Methyltransferase; Prognosis | 2022 |
Synergy between TMZ and individualized multimodal immunotherapy to improve overall survival of IDH1 wild-type MGMT promoter-unmethylated GBM patients.
Topics: Adult; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Glioblastoma; Humans; Immunotherapy; Isocitrate Dehydrogenase; Retrospective Studies; Temozolomide; Tumor Suppressor Proteins | 2022 |
Evaluating Quality Indicators of Glioblastoma Care: Audit Results From an Indian Tertiary Care Cancer Center.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Glioblastoma; Humans; Male; Middle Aged; Quality Indicators, Health Care; Retrospective Studies; Temozolomide; Tertiary Healthcare | 2022 |
Current trend of radiotherapy for glioblastoma in the elderly: a survey study by the brain tumor Committee of the Korean Radiation Oncology Group (KROG 21-05).
Topics: Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Glioblastoma; Humans; Republic of Korea; Surveys and Questionnaires; Temozolomide | 2022 |
Survival outcomes associated with MGMT promoter methylation and temozolomide in gliosarcoma patients.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Glioblastoma; Gliosarcoma; Humans; Temozolomide; Tumor Suppressor Proteins | 2022 |
MGMT in glial carcinogenesis. Roles from prevention to treatment.
Topics: Brain Neoplasms; Carcinogenesis; Carcinogens; Dacarbazine; DNA; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Humans; O(6)-Methylguanine-DNA Methyltransferase; Polycyclic Aromatic Hydrocarbons; Solvents; Temozolomide; Tumor Suppressor Proteins | 2022 |
Association of plasma levetiracetam concentration, MGMT methylation and sex with survival of chemoradiotherapy-treated glioblastoma patients.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemoradiotherapy; Dacarbazine; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Female; Glioblastoma; Humans; Levetiracetam; Male; Middle Aged; Prognosis; Retrospective Studies; Seizures; Temozolomide; Tumor Suppressor Proteins | 2022 |
Newly diagnosed Glioblastoma Multiforme (GBM) during COVID-19 pandemic: changes in therapeutic approach to minimize in-hospital SARS-COV-2 contagion in pre-vaccine era.
Topics: Brain Neoplasms; COVID-19; Dacarbazine; Glioblastoma; Hospitals; Humans; Pandemics; SARS-CoV-2; Vaccines | 2022 |
Continuing maintenance temozolomide therapy beyond 12 cycles confers no clinical benefit over discontinuation at 12 cycles in patients with IDH1/2-wildtype glioblastoma.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Disease Progression; Disease-Free Survival; DNA; Glioblastoma; Humans; Isocitrate Dehydrogenase; Methyltransferases; Temozolomide | 2022 |
Mechanism-based design of agents that selectively target drug-resistant glioma.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; DNA Methylation; DNA Modification Methylases; DNA Repair; DNA Repair Enzymes; Drug Design; Drug Resistance, Neoplasm; Glioblastoma; Humans; Temozolomide; Tumor Suppressor Proteins | 2022 |
Anticancer Effect of Cathelicidin LL-37, Protegrin PG-1, Nerve Growth Factor NGF, and Temozolomide: Impact on the Mitochondrial Metabolism, Clonogenic Potential, and Migration of Human U251 Glioma Cells.
Topics: Antimicrobial Cationic Peptides; Antineoplastic Agents, Alkylating; Apoptosis; Brain Neoplasms; Cathelicidins; Cell Line, Tumor; Dacarbazine; Drug Resistance, Neoplasm; Glioma; Humans; Mitochondria; Neoplasm Recurrence, Local; Nerve Growth Factor; Temozolomide | 2022 |
Improved survival among females and association with lymphopenia in patients with newly diagnosed glioblastoma.
Topics: Brain Neoplasms; Dacarbazine; Female; Glioblastoma; Humans; Lymphopenia; Temozolomide | 2022 |
Safety of temozolomide use in adult patients with renal dysfunction.
Topics: Adult; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Glioma; Humans; Kidney Diseases; Lymphopenia; Methylhydrazines; Neutropenia; Temozolomide; Thrombocytopenia | 2022 |
MEX3A Impairs DNA Mismatch Repair Signaling and Mediates Acquired Temozolomide Resistance in Glioblastoma.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; DNA Mismatch Repair; DNA Modification Methylases; DNA Repair Enzymes; Drug Resistance, Neoplasm; Glioblastoma; Humans; MutS Homolog 2 Protein; Neoplasm Recurrence, Local; RNA, Messenger; Temozolomide; Tumor Suppressor Proteins | 2022 |
Limited efficacy of temozolomide alone for astrocytoma, IDH-mutant, CNS WHO grades 2 or 3.
Topics: Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Dacarbazine; Humans; Isocitrate Dehydrogenase; Mutation; Retrospective Studies; Temozolomide; World Health Organization | 2022 |
Thymoquinone induces apoptosis in temozolomide-resistant glioblastoma cells via the p38 mitogen-activated protein kinase signaling pathway.
Topics: Animals; Antineoplastic Agents, Alkylating; Apoptosis; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; Drug Resistance, Neoplasm; Glioblastoma; Guanine; Mice; Mice, Nude; p38 Mitogen-Activated Protein Kinases; Purines; Signal Transduction; Temozolomide | 2023 |
Radiotherapy Plus Temozolomide With or Without Nimotuzumab Against the Newly Diagnosed EGFR-Positive Glioblastoma: A Retrospective Cohort Study.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; ErbB Receptors; Glioblastoma; Humans; Retrospective Studies; Temozolomide | 2023 |
Standard or extended STUPP? Optimal duration of temozolomide for patients with high-grade gliomas: a retrospective analysis.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Glioblastoma; Glioma; Humans; Retrospective Studies; Temozolomide | 2022 |
Stellettin B Sensitizes Glioblastoma to DNA-Damaging Treatments by Suppressing PI3K-Mediated Homologous Recombination Repair.
Topics: Animals; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; DNA Damage; Drug Resistance, Neoplasm; Glioblastoma; Humans; Mice; Phosphatidylinositol 3-Kinases; Recombinational DNA Repair; Temozolomide; Triterpenes; Zebrafish | 2023 |
The nanoprodrug of polytemozolomide combines with MGMT siRNA to enhance the effect of temozolomide in glioma.
Topics: Animals; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; Drug Resistance, Neoplasm; Glioma; O(6)-Methylguanine-DNA Methyltransferase; RNA, Small Interfering; Temozolomide | 2023 |
Impact of Extended Adjuvant Temozolamide Beyond 6 Months in the Management of Glioblastoma Patients.
Topics: Adjuvants, Immunologic; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemotherapy, Adjuvant; Dacarbazine; Disease-Free Survival; Glioblastoma; Humans; Temozolomide | 2023 |
Metronomic Temozolomide in Heavily Pretreated Patients With Recurrent Isocitrate Dehydrogenase Wild-type Glioblastoma: A Large Real-Life Mono-Institutional Study.
Topics: Adult; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Glioblastoma; Humans; Isocitrate Dehydrogenase; Middle Aged; Neoplasm Recurrence, Local; Retrospective Studies; Temozolomide | 2023 |
Letter to the editor regarding "The efficacy and safety of radiotherapy with adjuvant temozolomide for glioblastoma: A meta-analysis of randomized controlled studies".
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemotherapy, Adjuvant; Dacarbazine; Glioblastoma; Humans; Radiotherapy, Adjuvant; Temozolomide | 2023 |
Influence of MMR, MGMT Promotor Methylation and Protein Expression on Overall and Progression-Free Survival in Primary Glioblastoma Patients Treated with Temozolomide.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; DNA Methylation; DNA Mismatch Repair; DNA Modification Methylases; DNA Repair Enzymes; Glioblastoma; Humans; Methylation; O(6)-Methylguanine-DNA Methyltransferase; Progression-Free Survival; Temozolomide; Tumor Suppressor Proteins | 2023 |
Metastatic Melanoma: A Preclinical Model Standardization and Development of a Chitosan-Coated Nanoemulsion Containing Temozolomide to Treat Brain Metastasis.
Topics: Animals; Brain Neoplasms; Cell Line, Tumor; Chitosan; Dacarbazine; Humans; Melanoma; Mice; Temozolomide | 2023 |
Very long-term survival of an older glioblastoma patient after treatment with cilengitide: a case report.
Topics: Brain Neoplasms; Child; Dacarbazine; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Female; Glioblastoma; Humans; Prognosis; Temozolomide | 2023 |
GBP3-STING interaction in glioblastoma coordinates autophagy, anti-oxidative, and DNA repair programs in response to temozolomide.
Topics: Antineoplastic Agents, Alkylating; Autophagy; Brain Neoplasms; Dacarbazine; DNA Modification Methylases; DNA Repair; DNA Repair Enzymes; Drug Resistance, Neoplasm; Glioblastoma; GTP-Binding Proteins; Humans; Temozolomide | 2023 |
Identification of Patients With Glioblastoma Who May Benefit from Hypofractionated Radiotherapy.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Glioblastoma; Humans; Prognosis; Temozolomide | 2023 |
Discovery of new imidazotetrazinones with potential to overcome tumor resistance.
Topics: Antineoplastic Agents; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; Drug Resistance, Neoplasm; Glioblastoma; Humans; Temozolomide; Thiazoles | 2023 |
Treatment benefit in patients aged 80 years or older with biopsy-proven and non-resected glioblastoma is dependent on MGMT promoter methylation status.
Topics: Aged; Antineoplastic Agents, Alkylating; Biopsy; Brain Neoplasms; Dacarbazine; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Glioblastoma; Humans; Methylation; Prognosis; Tumor Suppressor Proteins | 2023 |
The Impact of O6-Methylguanine-DNA Methyltransferase (
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; DNA; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Humans; Leiomyosarcoma; Methyltransferases; Middle Aged; Retrospective Studies; Temozolomide; Tumor Suppressor Proteins | 2023 |
The antagonistic effects of temozolomide and trichostatin a combination on MGMT and DNA mismatch repair pathways in Glioblastoma.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; DNA Mismatch Repair; DNA Modification Methylases; DNA Repair Enzymes; Drug Resistance, Neoplasm; Glioblastoma; Humans; Temozolomide; Tumor Suppressor Proteins | 2023 |
Differences in clinical outcomes based on molecular markers in glioblastoma patients treated with concurrent tumor-treating fields and chemoradiation: exploratory analysis of the SPARE trial.
Topics: Adult; Antineoplastic Agents, Alkylating; Biomarkers; Brain Neoplasms; Dacarbazine; DNA Methylation; Glioblastoma; Humans; Precision Medicine; Temozolomide | 2023 |
Label-Free Raman Spectromicroscopy Unravels the Relationship between MGMT Methylation and Intracellular Lipid Accumulation in Glioblastoma.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Glioblastoma; Humans; Lipids; Temozolomide; Tumor Suppressor Proteins | 2023 |
Safety and Efficacy of Anlotinib Hydrochloride Plus Temozolomide in Patients with Recurrent Glioblastoma.
Topics: Adult; Aged; Angiogenesis Inhibitors; Brain Neoplasms; Dacarbazine; Glioblastoma; Humans; Middle Aged; Neoplasm Recurrence, Local; Temozolomide | 2023 |
Nitric Oxide Prevents Glioblastoma Stem Cells' Expansion and Induces Temozolomide Sensitization.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Dacarbazine; Drug Resistance, Neoplasm; Glioblastoma; Humans; Neoplastic Stem Cells; Nitric Oxide; Stem Cells; Temozolomide | 2023 |
Ex vivo drug sensitivity screening predicts response to temozolomide in glioblastoma patients and identifies candidate biomarkers.
Topics: Antineoplastic Agents, Alkylating; Biomarkers; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; DNA; Drug Evaluation, Preclinical; Drug Resistance, Neoplasm; Glioblastoma; Glioma; Humans; Temozolomide; Tumor Microenvironment | 2023 |
Long-term treatment outcomes of temozolomide-based chemoradiation in patients with adult-type diffuse IDH-mutant grade 2 astrocytoma.
Topics: Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Dacarbazine; Humans; Temozolomide; Treatment Outcome | 2023 |
Undetected pseudoprogressions in the CeTeG/NOA-09 trial: hints from postprogression survival and MRI analyses.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Glioblastoma; Humans; Lomustine; Magnetic Resonance Imaging; Temozolomide | 2023 |
Epigenetic Activation of TUSC3 Sensitizes Glioblastoma to Temozolomide Independent of MGMT Promoter Methylation Status.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Epigenesis, Genetic; Glioblastoma; Humans; O(6)-Methylguanine-DNA Methyltransferase; Temozolomide; Tumor Suppressor Proteins | 2023 |
Decreased eukaryotic initiation factors expression upon temozolomide treatment-potential novel implications for eIFs in glioma therapy.
Topics: Brain Neoplasms; Cell Line, Tumor; Dacarbazine; Glioblastoma; Glioma; Humans; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Temozolomide; TOR Serine-Threonine Kinases | 2023 |
Genomic Exploration of Distinct Molecular Phenotypes Steering Temozolomide Resistance Development in Patient-Derived Glioblastoma Cells.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Genomics; Glioblastoma; Humans; Phenotype; Temozolomide | 2023 |
Overcoming chemotherapy resistance in low-grade gliomas: A computational approach.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Glioma; Humans; Temozolomide | 2023 |
Treatment of glioblastoma in Greenlandic patients.
Topics: Adult; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemotherapy, Adjuvant; Dacarbazine; Glioblastoma; Humans; Temozolomide | 2023 |
Identification of potential glioma drug resistance target proteins based on ultra-performance liquid chromatography-mass spectrometry differential proteomics.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Line, Tumor; Chromatography, Liquid; Dacarbazine; Drug Resistance, Neoplasm; Glioblastoma; Glioma; Humans; Proteomics; Tandem Mass Spectrometry; Temozolomide | 2023 |
Mitigating temozolomide resistance in glioblastoma via DNA damage-repair inhibition.
Topics: Brain Neoplasms; Cell Line, Tumor; Dacarbazine; DNA Damage; DNA Repair; Drug Resistance, Neoplasm; Glioblastoma; Humans; Temozolomide | 2020 |
The clinical, radiological, and immunohistochemical characteristics and outcomes of primary intracranial gliosarcoma: a retrospective single-centre study.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Female; Gliosarcoma; Humans; Immunohistochemistry; Male; Middle Aged; Neoplasm Recurrence, Local; Progression-Free Survival; Retrospective Studies; Risk Factors; Salvage Therapy; Temozolomide; Treatment Outcome | 2021 |
Newly diagnosed glioblastoma in the elderly: when is temozolomide alone enough?
Topics: Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Glioblastoma; Humans; Temozolomide | 2020 |
Chemotherapy toxicities and geriatric syndromes in older patients with malignant gliomas.
Topics: Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemotherapy, Adjuvant; Dacarbazine; Glioblastoma; Glioma; Humans; Retrospective Studies; Syndrome | 2021 |
Developing a clinically relevant radiosensitizer for temozolomide-resistant gliomas.
Topics: Animals; Blood-Brain Barrier; Brain; Brain Neoplasms; Cell Line, Tumor; Cell Survival; Dacarbazine; DNA Damage; Drug Resistance, Neoplasm; Gas Chromatography-Mass Spectrometry; Glioma; Humans; Mice; Mice, Inbred C57BL; O(6)-Methylguanine-DNA Methyltransferase; Radiation-Sensitizing Agents; Temozolomide; Xenograft Model Antitumor Assays | 2020 |
Clinical Efficacy of Tumor Treating Fields for Newly Diagnosed Glioblastoma.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Disease-Free Survival; Female; Glioblastoma; Humans; Male; Middle Aged; Survival Rate; Temozolomide; Treatment Outcome | 2020 |
Actual body weight dosing of temozolomide and overall survival in patients with glioblastoma.
Topics: Adult; Antineoplastic Agents, Alkylating; Body Weight; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Glioblastoma; Humans; Retrospective Studies; Temozolomide | 2021 |
Determination of the cutoff point of the absolute value of MGMTmRNA for predicting the therapeutic resistance to temozolomide in glioblastoma.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; DNA Methylation; Drug Resistance, Neoplasm; Glioblastoma; Humans; Prognosis; Temozolomide | 2020 |
Desquamative skin rash associated with temozolomide in a patient with glioblastoma.
Topics: Brain Neoplasms; Dacarbazine; Exanthema; Glioblastoma; Humans; Temozolomide | 2021 |
Early results from the CODEL trial for anaplastic oligodendrogliomas: is temozolomide futile?
Topics: Brain Neoplasms; Dacarbazine; Humans; Oligodendroglioma; Temozolomide | 2021 |
Adjuvant chemotherapy after severe myelotoxicity during chemoradiation phase in malignant gliomas. Is it feasibile? Results from AINO study (Italian Association for Neuro-Oncology).
Topics: Adult; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemoradiotherapy; Chemotherapy, Adjuvant; Dacarbazine; Female; Glioblastoma; Glioma; Humans; Italy; Neoplasm Recurrence, Local; Retrospective Studies | 2021 |
Prognostic value of TP53 expression and MGMT methylation in glioblastoma patients treated with temozolomide combined with other chemotherapies.
Topics: Antineoplastic Agents; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Glioblastoma; Humans; O(6)-Methylguanine-DNA Methyltransferase; Prognosis; Temozolomide; Tumor Suppressor Protein p53; Tumor Suppressor Proteins | 2021 |
Treatment patterns and outcomes for patients with newly diagnosed glioblastoma multiforme: a retrospective cohort study.
Topics: Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Glioblastoma; Humans; Retrospective Studies; Tumor Suppressor Proteins | 2021 |
Safety and Tolerance of D,L-Methadone in Combination with Chemotherapy in Patients with Glioma.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Biopsy; Brain Neoplasms; Clinical Trials as Topic; Dacarbazine; Disease-Free Survival; DNA Modification Methylases; DNA Repair Enzymes; Female; Glioblastoma; Glioma; Humans; Male; Methadone; Middle Aged; Patient Safety; Proportional Hazards Models; Retrospective Studies; Risk; Surveys and Questionnaires; Treatment Outcome; Tumor Suppressor Proteins | 2017 |
Answer to the comment of Hai Lu et al. regarding "Hepatotoxicity by combination treatment of temozolomide, artesunate and Chinese herbs in a glioblastoma multiforme patient: case report and review of the literature. Arch Toxicol (2016)".
Topics: Artemisinins; Artesunate; Brain Neoplasms; Chemical and Drug Induced Liver Injury; Dacarbazine; Glioblastoma; Humans; Temozolomide | 2017 |
The allosteric AKT inhibitor MK2206 shows a synergistic interaction with chemotherapy and radiotherapy in glioblastoma spheroid cultures.
Topics: Antineoplastic Agents, Alkylating; Blotting, Western; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Dacarbazine; Drug Synergism; Glioblastoma; Heterocyclic Compounds, 3-Ring; Humans; Phosphatidylinositol 3-Kinase; Phosphorylation; Proto-Oncogene Proteins c-akt; Signal Transduction; Spheroids, Cellular; Temozolomide | 2017 |
MiR-223/PAX6 Axis Regulates Glioblastoma Stem Cell Proliferation and the Chemo Resistance to TMZ via Regulating PI3K/Akt Pathway.
Topics: Brain Neoplasms; Cell Proliferation; Dacarbazine; Drug Resistance, Neoplasm; Female; Glioblastoma; Humans; Male; MicroRNAs; Neoplastic Stem Cells; PAX6 Transcription Factor; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; RNA, Neoplasm; Signal Transduction; Temozolomide | 2017 |
Tumortropic adipose-derived stem cells carrying smart nanotherapeutics for targeted delivery and dual-modality therapy of orthotopic glioblastoma.
Topics: Adipocytes; Animals; Antineoplastic Agents; Biological Transport; Blood-Brain Barrier; Brain Neoplasms; Cell Line, Tumor; Cell Movement; Cell Survival; Dacarbazine; Drug Carriers; Drug Liberation; Glioblastoma; Humans; Lactic Acid; Magnetite Nanoparticles; Male; Mice, Inbred C57BL; Molecular Targeted Therapy; Oleic Acid; Paclitaxel; Particle Size; Permeability; Polyglutamic Acid; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Stem Cells; Surface Properties; Temozolomide; Tissue Distribution | 2017 |
Temozolomide-Mediated Apoptotic Death Is Improved by Thymoquinone in U87MG Cell Line.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Benzoquinones; Brain Neoplasms; Cell Line, Tumor; Comet Assay; Cytochromes c; Dacarbazine; Drug Synergism; Glioblastoma; Glutathione; Humans; In Situ Nick-End Labeling; Membrane Potential, Mitochondrial; Nitric Oxide; Reactive Oxygen Species; Staining and Labeling; Temozolomide | 2017 |
Lithium enhances the antitumour effect of temozolomide against TP53 wild-type glioblastoma cells via NFAT1/FasL signalling.
Topics: Aged; Animals; Antibodies, Neutralizing; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; Fas Ligand Protein; Female; Gene Knockdown Techniques; Glioblastoma; Glycogen Synthase Kinase 3; Humans; Lithium; Male; Mice; Middle Aged; Neoplasm Transplantation; NFATC Transcription Factors; Primary Cell Culture; Protein Transport; Signal Transduction; Survival Rate; Temozolomide; Tumor Suppressor Protein p53 | 2017 |
Management and Survival Patterns of Patients with Gliomatosis Cerebri: A SEER-Based Analysis.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Combined Modality Therapy; Cranial Irradiation; Dacarbazine; Disease Management; Female; Glioblastoma; Glioma; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Neoplasms, Multiple Primary; Neoplasms, Neuroepithelial; Neurosurgical Procedures; Oligodendroglioma; Proportional Hazards Models; Retrospective Studies; SEER Program; Survival Rate; Temozolomide | 2017 |
Is more better? The impact of extended adjuvant temozolomide in newly diagnosed glioblastoma: a secondary analysis of EORTC and NRG Oncology/RTOG.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Disease Progression; Disease-Free Survival; Female; Glioblastoma; Humans; Male; Middle Aged; Temozolomide; Tumor Suppressor Proteins | 2017 |
Dual bioluminescence and near-infrared fluorescence monitoring to evaluate spherical nucleic acid nanoconjugate activity in vivo.
Topics: Animals; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; Female; Fluorescence; Glioblastoma; Humans; Mice; Mice, SCID; Nanoconjugates; RNA Interference; RNA, Small Interfering; Temozolomide; Tumor Cells, Cultured; Tumor Suppressor Proteins; Xenograft Model Antitumor Assays | 2017 |
Mustard-inspired delivery shuttle for enhanced blood-brain barrier penetration and effective drug delivery in glioma therapy.
Topics: Animals; Antineoplastic Agents, Alkylating; Biological Transport; Blood-Brain Barrier; Brain Neoplasms; Cattle; Cell Line, Tumor; Coumaric Acids; Dacarbazine; Drug Carriers; Drug Delivery Systems; Glioma; Humans; Mice; Models, Molecular; Mustard Plant; Nanoparticles; Phosphorylcholine; Polymethacrylic Acids; Rats; Serum Albumin, Bovine; Temozolomide; Tissue Distribution | 2017 |
β-Asarone promotes Temozolomide's entry into glioma cells and decreases the expression of P-glycoprotein and MDR1.
Topics: Allylbenzene Derivatives; Animals; Anisoles; Antineoplastic Agents, Alkylating; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Dacarbazine; Drug Resistance, Neoplasm; Glioma; Humans; Rats; RNA, Messenger; Temozolomide | 2017 |
How can we develop therapies for glioblastoma more efficiently? Randomized versus single-arm studies.
Topics: Adult; Brain Neoplasms; Dacarbazine; Glioblastoma; Humans | 2017 |
Point/counterpoint: randomized versus single-arm phase II clinical trials for patients with newly diagnosed glioblastoma.
Topics: Brain Neoplasms; Clinical Trials, Phase II as Topic; Dacarbazine; Glioblastoma; Humans; Randomized Controlled Trials as Topic; Treatment Outcome | 2017 |
Influence of incidental radiation dose in the subventricular zone on survival in patients with glioblastoma multiforme treated with surgery, radiotherapy, and temozolomide.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Female; Follow-Up Studies; Glioblastoma; Humans; Lateral Ventricles; Male; Middle Aged; Prognosis; Radiation Dosage; Retrospective Studies; Survival Rate; Temozolomide | 2017 |
Dual treatment with shikonin and temozolomide reduces glioblastoma tumor growth, migration and glial-to-mesenchymal transition.
Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Dacarbazine; Drug Resistance, Neoplasm; Epithelial-Mesenchymal Transition; Glioblastoma; Humans; Naphthoquinones; Temozolomide | 2017 |
[Combining radiation plus temozolomide in glioblastoma patients older than 65 years of age].
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Glioblastoma; Humans | 2017 |
Differential pro-apoptotic effects of synthetic 4-thiazolidinone derivative Les-3288, doxorubicin and temozolomide in human glioma U251 cells.
Topics: Antineoplastic Agents; Apoptosis; Blood-Brain Barrier; Brain Neoplasms; Caspase 3; Cell Line, Tumor; Cell Survival; Dacarbazine; Dose-Response Relationship, Drug; Doxorubicin; Glioma; Humans; Reactive Oxygen Species; Temozolomide; Thiazolidines | 2017 |
Correlations of MGMT genetic polymorphisms with temozolomide resistance and prognosis of patients with malignant gliomas: a population-based study in China.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Asian People; Brain Neoplasms; China; Dacarbazine; Drug Resistance, Neoplasm; Female; Genotype; Glioma; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Nausea; O(6)-Methylguanine-DNA Methyltransferase; Polymorphism, Genetic; Prognosis; Temozolomide; Vomiting | 2017 |
Promoting oligodendroglial-oriented differentiation of glioma stem cell: a repurposing of quetiapine for the treatment of malignant glioma.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cell Differentiation; Cell Line, Tumor; Dacarbazine; Drug Repositioning; Drug Synergism; Glioma; Humans; Mice, Inbred C57BL; Mice, Nude; Neoplasms, Experimental; Neoplastic Stem Cells; Oligodendroglia; Quetiapine Fumarate; Temozolomide; Tumor Burden | 2017 |
Tumor microtubes convey resistance to surgical lesions and chemotherapy in gliomas.
Topics: Animals; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Dacarbazine; Drug Resistance, Neoplasm; Glioma; Humans; Mice, Nude; Temozolomide | 2017 |
The stem cell/cancer stem cell marker ALDH1A3 regulates the expression of the survival factor tissue transglutaminase, in mesenchymal glioma stem cells.
Topics: Aldehyde Oxidoreductases; Biomarkers, Tumor; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dacarbazine; Gene Expression Regulation, Neoplastic; Glioma; GTP-Binding Proteins; Humans; Mesenchymal Stem Cells; Neoplastic Stem Cells; Protein Glutamine gamma Glutamyltransferase 2; RNA, Small Interfering; Stem Cells; Temozolomide; Transglutaminases; Tretinoin; Up-Regulation | 2017 |
MiR-198 enhances temozolomide sensitivity in glioblastoma by targeting MGMT.
Topics: Adult; Aged; Animals; Antineoplastic Agents, Alkylating; Astrocytes; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; Drug Resistance, Neoplasm; Female; Glioblastoma; Human Umbilical Vein Endothelial Cells; Humans; Male; Mice, Inbred NOD; Mice, SCID; MicroRNAs; Middle Aged; Neoplasm Transplantation; RNA, Messenger; Temozolomide; Tumor Suppressor Proteins; Young Adult | 2017 |
Biological activity of tumor-treating fields in preclinical glioma models.
Topics: Apoptosis; Brain Neoplasms; Caspases; Cell Cycle; Cell Line, Tumor; Cell Movement; Cell Survival; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; Glioma; Humans; Neoplasm Invasiveness; Temozolomide; Tumor Suppressor Proteins | 2017 |
IDH1 R132H mutation regulates glioma chemosensitivity through Nrf2 pathway.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Glioma; Humans; Isocitrate Dehydrogenase; Multidrug Resistance-Associated Proteins; Mutation; NAD(P)H Dehydrogenase (Quinone); NF-E2-Related Factor 2; Signal Transduction; Temozolomide; Tumor Suppressor Protein p53 | 2017 |
A case of glioblastoma resected immediately after administering bevacizumab: consideration on histopathological findings and safety of surgery.
Topics: Adult; Bevacizumab; Brain Neoplasms; Combined Modality Therapy; Craniotomy; Dacarbazine; Humans; Intracranial Thrombosis; Male; Oligodendroglioma; Radiotherapy; Temozolomide; Treatment Outcome; Venous Thrombosis | 2017 |
Small molecules targeting histone demethylase genes (KDMs) inhibit growth of temozolomide-resistant glioblastoma cells.
Topics: Aminopyridines; Animals; Blood-Brain Barrier; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dacarbazine; Drug Resistance, Neoplasm; Drug Synergism; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Glioblastoma; Histone Demethylases; Humans; Hydrazones; Mice; Phosphorylation; Proto-Oncogene Proteins c-akt; Retinoblastoma-Binding Protein 2; Small Molecule Libraries; Temozolomide; Xenograft Model Antitumor Assays | 2017 |
Expression and function of ABCG2 and XIAP in glioblastomas.
Topics: Adult; Aged; Aged, 80 and over; Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily G, Member 2; Brain Neoplasms; Cells, Cultured; Dacarbazine; Diketopiperazines; Female; Follow-Up Studies; Glioblastoma; Heterocyclic Compounds, 4 or More Rings; Humans; Indoles; Male; Mice, Inbred NOD; Mice, Knockout; Mice, SCID; Middle Aged; Neoplasm Proteins; Neoplasm Transplantation; Neoplastic Stem Cells; Temozolomide; X-Linked Inhibitor of Apoptosis Protein | 2017 |
Recurrence Pattern Analysis of Primary Glioblastoma.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemoradiotherapy, Adjuvant; Dacarbazine; Disease-Free Survival; Female; Glioblastoma; Humans; Karnofsky Performance Status; Male; Middle Aged; Neoplasm Recurrence, Local; Neurosurgical Procedures; Retrospective Studies; Survival Rate; Temozolomide | 2017 |
EMAP-II sensitize U87MG and glioma stem-like cells to temozolomide via induction of autophagy-mediated cell death and G2/M arrest.
Topics: Apoptosis; Autophagy; Brain Neoplasms; Cell Cycle Checkpoints; Cell Line, Tumor; Cytokines; Dacarbazine; G2 Phase; Glioblastoma; Humans; Mitosis; Neoplasm Proteins; Neoplastic Stem Cells; RNA-Binding Proteins; Signal Transduction; Temozolomide | 2017 |
Depletion of adult neurogenesis using the chemotherapy drug temozolomide in mice induces behavioural and biological changes relevant to depression.
Topics: Animals; Antineoplastic Agents, Alkylating; Behavior, Animal; Biochemical Phenomena; Brain; Brain Neoplasms; Corticosterone; Dacarbazine; Dentate Gyrus; Depressive Disorder; Disease Models, Animal; Humans; Male; Mice; Mice, Inbred C57BL; Neurogenesis; Prevalence; Stress Disorders, Traumatic, Acute; Temozolomide | 2017 |
Downregulation of β-arrestin 1 suppresses glioblastoma cell malignant progression vis inhibition of Src signaling.
Topics: Animals; beta-Arrestin 1; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Dacarbazine; Disease Progression; Down-Regulation; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Mice; Neoplasm Invasiveness; Proto-Oncogene Proteins pp60(c-src); Signal Transduction; Temozolomide | 2017 |
Aspirin inhibits the SHH/GLI1 signaling pathway and sensitizes malignant glioma cells to temozolomide therapy.
Topics: Antineoplastic Agents, Alkylating; Apoptosis; Aspirin; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; DNA Repair; Drug Synergism; Epithelial-Mesenchymal Transition; Glioma; Hedgehog Proteins; Humans; Signal Transduction; Temozolomide; Translocation, Genetic; Zinc Finger Protein GLI1 | 2017 |
Repositioning chlorpromazine for treating chemoresistant glioma through the inhibition of cytochrome c oxidase bearing the COX4-1 regulatory subunit.
Topics: Animals; Antineoplastic Agents, Alkylating; Antipsychotic Agents; Brain Neoplasms; Cattle; Cell Line, Tumor; Cell Proliferation; Chlorpromazine; Dacarbazine; Dopamine Antagonists; Drug Repositioning; Drug Resistance, Neoplasm; Electron Transport Complex IV; Glioma; Humans; Mice, Nude; Mitochondria, Heart; Temozolomide; Xenograft Model Antitumor Assays | 2017 |
Long-term benefit of intra-arterial bevacizumab for recurrent glioblastoma.
Topics: Adult; Bevacizumab; Blood-Brain Barrier; Brain Neoplasms; Dacarbazine; Glioblastoma; Humans; Male; Neoplasm Recurrence, Local; Temozolomide | 2017 |
Developing an Algorithm for Optimizing Care of Elderly Patients With Glioblastoma.
Topics: Adult; Aged; Aged, 80 and over; Algorithms; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Female; Glioblastoma; Humans; Male; Middle Aged; Multivariate Analysis; Retrospective Studies; Temozolomide | 2018 |
Combination therapy with micellarized cyclopamine and temozolomide attenuate glioblastoma growth through Gli1 down-regulation.
Topics: Apoptosis; Brain Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Dacarbazine; Drug Synergism; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Micelles; Signal Transduction; Temozolomide; Tumor Stem Cell Assay; Veratrum Alkaloids; Zinc Finger Protein GLI1 | 2017 |
TREATMENT OF PROGRESSION OF DIFFUSE ASTROCYTOMA BY HERBAL MEDICINE: CASE REPORT.
Topics: Adult; Antineoplastic Agents; Astrocytoma; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Disease Progression; Female; Humans; Phytotherapy; Plant Preparations; Plants, Medicinal; Temozolomide; Treatment Outcome | 2016 |
Comparative analysis of the effects of a sphingosine kinase inhibitor to temozolomide and radiation treatment on glioblastoma cell lines.
Topics: Antineoplastic Agents, Alkylating; Apoptosis; Brain Neoplasms; Cell Line, Tumor; Cell Survival; Chemoradiotherapy; Dacarbazine; Drug Screening Assays, Antitumor; Drug Synergism; Glioblastoma; Humans; Phosphotransferases (Alcohol Group Acceptor); Radiation Tolerance; Radiation-Sensitizing Agents; Temozolomide | 2017 |
Reversing glioma malignancy: a new look at the role of antidepressant drugs as adjuvant therapy for glioblastoma multiforme.
Topics: Antidepressive Agents; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Line, Tumor; Cell Survival; Chemotherapy, Adjuvant; Dacarbazine; Glioblastoma; Glioma; Humans; Hypoxia; Mitochondria; Neoplastic Stem Cells; Temozolomide; Xenograft Model Antitumor Assays | 2017 |
MiR-181b modulates chemosensitivity of glioblastoma multiforme cells to temozolomide by targeting the epidermal growth factor receptor.
Topics: Animals; Antineoplastic Agents, Alkylating; Apoptosis; Brain; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; Drug Resistance, Neoplasm; ErbB Receptors; Glioblastoma; Humans; Male; Mice, Inbred BALB C; Mice, Nude; MicroRNAs; Neoplasm Recurrence, Local; Neoplasm Transplantation; Random Allocation; Temozolomide | 2017 |
The redox couple avarol/avarone in the fight with malignant gliomas: the case study of U-251 MG cells.
Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cell Line, Tumor; Comet Assay; Cyclohexenes; Dacarbazine; DNA Damage; Doxorubicin; Fibroblasts; Glioma; Humans; Oxidation-Reduction; Sesquiterpenes; Temozolomide | 2018 |
Establishment of a tumor sphere cell line from a metastatic brain neuroendocrine tumor.
Topics: AC133 Antigen; Aged; Aldehyde Dehydrogenase; Animals; Antineoplastic Agents, Alkylating; Biomarkers, Tumor; Brain Neoplasms; Cell Survival; Chromogranin A; Dacarbazine; Humans; Male; Mice; Neoplasm Transplantation; Neoplastic Stem Cells; Nestin; Neuroendocrine Tumors; Primary Cell Culture; SOXB1 Transcription Factors; Spheroids, Cellular; Synaptophysin; Temozolomide; Tumor Cells, Cultured | 2017 |
Defining optimal cutoff value of MGMT promoter methylation by ROC analysis for clinical setting in glioblastoma patients.
Topics: Antineoplastic Agents, Alkylating; Area Under Curve; Brain Neoplasms; CpG Islands; Dacarbazine; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Drug Resistance, Neoplasm; Female; Glioblastoma; Humans; Kaplan-Meier Estimate; Karnofsky Performance Status; Male; Middle Aged; Prognosis; Promoter Regions, Genetic; Proportional Hazards Models; ROC Curve; Temozolomide; Tumor Suppressor Proteins | 2017 |
A Survival Analysis with Identification of Prognostic Factors in a Series of 110 Patients with Newly Diagnosed Glioblastoma Before and After Introduction of the Stupp Regimen: A Single-Center Observational Study.
Topics: Adult; Aged; Brain Neoplasms; Carmustine; Chemotherapy, Adjuvant; Combined Modality Therapy; Craniotomy; Dacarbazine; Disease-Free Survival; Female; Follow-Up Studies; Glioblastoma; Humans; Male; Margins of Excision; Middle Aged; Multivariate Analysis; Postoperative Complications; Prognosis; Radiotherapy, Adjuvant; Retrospective Studies; Serbia; Survival Analysis; Temozolomide | 2017 |
Changes in tumor cell heterogeneity after chemotherapy treatment in a xenograft model of glioblastoma.
Topics: Animals; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; Disease Models, Animal; Glioblastoma; Heterografts; Humans; Neoplastic Stem Cells; Temozolomide; Xenograft Model Antitumor Assays | 2017 |
Guanosine promotes cytotoxicity via adenosine receptors and induces apoptosis in temozolomide-treated A172 glioma cells.
Topics: Antineoplastic Agents, Alkylating; Apoptosis; Autophagy; Brain Neoplasms; Cell Line, Tumor; Cell Survival; Dacarbazine; Glioma; Guanosine; Humans; Membrane Potential, Mitochondrial; Receptors, Purinergic P1; Temozolomide | 2017 |
Impact of interim progression during the surgery-to-radiotherapy interval and its predictors in glioblastoma treated with temozolomide-based radiochemotherapy.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemoradiotherapy; Dacarbazine; Disease Progression; Female; Follow-Up Studies; Glioblastoma; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Neurosurgical Procedures; Proportional Hazards Models; Temozolomide | 2017 |
When less is better: care of the elderly with glioblastoma.
Topics: Aged; Brain Neoplasms; Dacarbazine; Glioblastoma; Humans | 2017 |
Front-line glioblastoma chemotherapeutic temozolomide is toxic to Trypanosoma brucei and potently enhances melarsoprol and eflornithine.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Drug Therapy, Combination; Eflornithine; Glioblastoma; HL-60 Cells; Humans; Melarsoprol; Temozolomide; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African | 2017 |
Atorvastatin augments temozolomide's efficacy in glioblastoma via prenylation-dependent inhibition of Ras signaling.
Topics: Animals; Atorvastatin; Brain Neoplasms; Cell Proliferation; Cell Survival; Dacarbazine; Disease Models, Animal; Glioblastoma; Humans; Mice; Neoplasms, Experimental; ras Proteins; Signal Transduction; Temozolomide; Tumor Cells, Cultured | 2017 |
Radiation plus Temozolomide in Patients with Glioblastoma.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Glioblastoma; Humans | 2017 |
Radiation plus Temozolomide in Patients with Glioblastoma.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Glioblastoma; Humans | 2017 |
Therapeutic targeting of chemoresistant and recurrent glioblastoma stem cells with a proapoptotic variant of oncolytic herpes simplex virus.
Topics: Animals; Apoptosis; Brain Neoplasms; Cell Line, Tumor; Cohort Studies; Dacarbazine; Drug Resistance, Neoplasm; Glioblastoma; HEK293 Cells; Humans; Mice; Neoplasm Recurrence, Local; Neoplastic Stem Cells; Oncolytic Virotherapy; Simplexvirus; Temozolomide; TNF-Related Apoptosis-Inducing Ligand | 2017 |
CBF1 is clinically prognostic and serves as a target to block cellular invasion and chemoresistance of EMT-like glioblastoma cells.
Topics: Antineoplastic Agents, Alkylating; Blotting, Western; Brain Neoplasms; Cell Line, Tumor; Cell Survival; Computer Simulation; Dacarbazine; Databases, Factual; Drug Resistance, Neoplasm; Epithelial-Mesenchymal Transition; Glioblastoma; Glycolysis; Humans; Immunoglobulin J Recombination Signal Sequence-Binding Protein; Isocitrate Dehydrogenase; Mutation; Neoplasm Invasiveness; Neoplastic Stem Cells; Prognosis; RNA, Messenger; Temozolomide; Tumor Hypoxia; Zinc Finger E-box-Binding Homeobox 1 | 2017 |
The rs16906252:C>T SNP is not associated with increased overall survival or temozolomide response in a Han-Chinese glioma cohort.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Brain Neoplasms; China; Cohort Studies; Dacarbazine; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Ethnicity; Female; Glioma; Humans; Male; Middle Aged; Polymorphism, Single Nucleotide; Prognosis; Promoter Regions, Genetic; Survival Analysis; Temozolomide; Tumor Suppressor Proteins; Young Adult | 2017 |
Survival Outcomes of Elderly Patients With Glioblastoma Multiforme in Their 75th Year or Older Treated With Adjuvant Therapy.
Topics: Age Factors; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemotherapy, Adjuvant; Dacarbazine; Disease-Free Survival; DNA Modification Methylases; DNA Repair Enzymes; Glioblastoma; Humans; Kaplan-Meier Estimate; Methylation; Multivariate Analysis; Radiotherapy Dosage; Radiotherapy, Intensity-Modulated; Regression Analysis; Retrospective Studies; Temozolomide; Time Factors; Tumor Suppressor Proteins | 2017 |
High Expression of Glypican-1 Predicts Dissemination and Poor Prognosis in Glioblastomas.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain; Brain Neoplasms; Dacarbazine; Disease Progression; DNA Modification Methylases; DNA Repair Enzymes; Female; Glioblastoma; Glypicans; Humans; Isocitrate Dehydrogenase; Karnofsky Performance Status; Ki-67 Antigen; Logistic Models; Magnetic Resonance Imaging; Male; Middle Aged; Retrospective Studies; Temozolomide; Tumor Suppressor Proteins | 2017 |
Effects of Connexin43 Overexpression on U251 Cell Growth, Migration, and Apoptosis.
Topics: Apoptosis; Brain Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Connexin 43; Dacarbazine; Glioma; Green Fluorescent Proteins; Humans; Neoplasm Proteins; Temozolomide; Transfection | 2017 |
Connective tissue growth factor promotes temozolomide resistance in glioblastoma through TGF-β1-dependent activation of Smad/ERK signaling.
Topics: Animals; Antineoplastic Agents, Alkylating; Apoptosis; Brain Neoplasms; Cell Line, Tumor; Connective Tissue Growth Factor; Cytokines; Dacarbazine; Drug Resistance, Neoplasm; Extracellular Signal-Regulated MAP Kinases; Flow Cytometry; Glioblastoma; Humans; Hyaluronan Receptors; Male; Mice; Mice, Nude; Neoplasm Transplantation; Signal Transduction; Smad Proteins; Temozolomide; Transforming Growth Factor beta1 | 2017 |
New strategies for cancer management: how can temozolomide carrier modifications improve its delivery?
Topics: Antineoplastic Agents, Alkylating; Blood-Brain Barrier; Brain Neoplasms; Dacarbazine; Drug Carriers; Glioblastoma; Humans; Nanoparticles; Polymers; Temozolomide | 2017 |
Frameless stereotactic radiotherapy alone and combined with temozolomide for presumed canine gliomas.
Topics: Animals; Antineoplastic Agents, Alkylating; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Dog Diseases; Dogs; Female; Glioma; Male; Radiosurgery; Survival Analysis; Temozolomide | 2018 |
A Novel Theranostic Strategy for
Topics: Animals; Antineoplastic Agents; Apoptosis; Brain Neoplasms; Cell Line, Tumor; Cell Survival; Dacarbazine; Disease Models, Animal; Ferric Compounds; Flow Cytometry; Gene Expression; Glioblastoma; Humans; Magnetic Resonance Imaging; Mass Spectrometry; Matrix Metalloproteinase 14; Mice; Nanoparticles; Temozolomide; Theranostic Nanomedicine; Xenograft Model Antitumor Assays | 2017 |
Liposomal temozolomide drug delivery using convection enhanced delivery.
Topics: Animals; Antineoplastic Agents, Alkylating; Brain Neoplasms; Convection; Dacarbazine; Drug Delivery Systems; Gadolinium DTPA; Glioblastoma; Liposomes; Male; Nanoparticles; Particle Size; Polyethylene Glycols; Rats; Rats, Inbred Lew; Rats, Sprague-Dawley; Survival Rate; Temozolomide; Tumor Burden | 2017 |
Systemic Intravenous Adoptive Transfer of Autologous Lymphokine-activated αβ T-Cells Improves Temozolomide-induced Lymphopenia in Patients with Glioma.
Topics: Administration, Intravenous; Adolescent; Adult; Aged; Brain Neoplasms; Cell Line, Tumor; Child; Dacarbazine; Female; Glioma; Humans; Immunotherapy, Adoptive; Lymphopenia; Male; Middle Aged; Prospective Studies; T-Lymphocyte Subsets; Temozolomide; Transplantation, Autologous; Treatment Outcome; Young Adult | 2017 |
Long Non-Coding RNA MALAT1 Decreases the Sensitivity of Resistant Glioblastoma Cell Lines to Temozolomide.
Topics: Antineoplastic Agents, Alkylating; Brain; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; Drug Resistance, Neoplasm; Epithelial-Mesenchymal Transition; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; RNA, Long Noncoding; Temozolomide; Up-Regulation; Zinc Finger E-box-Binding Homeobox 1 | 2017 |
Long-term outcomes of concomitant chemoradiotherapy with temozolomide for newly diagnosed glioblastoma patients: A single-center analysis.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemoradiotherapy; Dacarbazine; Disease-Free Survival; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Female; Follow-Up Studies; Glioblastoma; Humans; Male; Middle Aged; Prognosis; Promoter Regions, Genetic; Retrospective Studies; Temozolomide; Treatment Outcome; Tumor Suppressor Proteins; Young Adult | 2017 |
In vitro nuclear magnetic resonance spectroscopy metabolic biomarkers for the combination of temozolomide with PI3K inhibition in paediatric glioblastoma cells.
Topics: Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Child; Dacarbazine; Furans; Glioblastoma; Humans; Lactic Acid; Phosphorylcholine; Proton Magnetic Resonance Spectroscopy; Pyridines; Pyrimidines; Temozolomide; Treatment Outcome | 2017 |
Genomic profiling of long non-coding RNA and mRNA expression associated with acquired temozolomide resistance in glioblastoma cells.
Topics: Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dacarbazine; Drug Resistance, Neoplasm; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Regulatory Networks; Glioblastoma; Humans; Oligonucleotide Array Sequence Analysis; RNA, Long Noncoding; RNA, Messenger; Temozolomide | 2017 |
Risk of severe acute liver injury among patients with brain cancer treated with temozolomide: a nested case-control study using the healthcore integrated research database.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Case-Control Studies; Chemical and Drug Induced Liver Injury; Cohort Studies; Dacarbazine; Databases, Factual; Delivery of Health Care; Disease-Free Survival; Female; Glioblastoma; Humans; Male; Middle Aged; Temozolomide; Young Adult | 2017 |
A polymeric temozolomide nanocomposite against orthotopic glioblastoma xenograft: tumor-specific homing directed by nestin.
Topics: Animals; Blood-Brain Barrier; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; Ferric Compounds; Glioblastoma; Heterografts; Humans; Mice, Inbred BALB C; Mice, Inbred NOD; Mice, SCID; Nanocomposites; Nanoparticles; Nestin; Temozolomide; Xenograft Model Antitumor Assays | 2017 |
Perfusion of surgical cavity wall enhancement in early post-treatment MR imaging may stratify the time-to-progression in glioblastoma.
Topics: Aged; Brain Neoplasms; Chemoradiotherapy; Combined Modality Therapy; Contrast Media; Dacarbazine; Disease Progression; Female; Glioblastoma; Humans; Image Interpretation, Computer-Assisted; Kaplan-Meier Estimate; Magnetic Resonance Imaging; Male; Perfusion; Spin Labels; Temozolomide | 2017 |
β-asarone inhibited cell growth and promoted autophagy via P53/Bcl-2/Bclin-1 and P53/AMPK/mTOR pathways in Human Glioma U251 cells.
Topics: Allylbenzene Derivatives; AMP-Activated Protein Kinases; Anisoles; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Autophagosomes; Autophagy; Beclin-1; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Shape; Dacarbazine; Glioma; Humans; Phosphorylation; Proto-Oncogene Proteins c-bcl-2; Signal Transduction; Temozolomide; TOR Serine-Threonine Kinases; Tumor Suppressor Protein p53 | 2018 |
FERMT3 contributes to glioblastoma cell proliferation and chemoresistance to temozolomide through integrin mediated Wnt signaling.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Dacarbazine; Drug Resistance, Neoplasm; Female; Glioblastoma; Humans; Integrins; Male; Membrane Proteins; Middle Aged; Neoplasm Proteins; Temozolomide; Wnt Signaling Pathway | 2017 |
Successful use of equine anti-thymocyte globulin (ATGAM) for fulminant myocarditis secondary to nivolumab therapy.
Topics: Animals; Antibodies, Monoclonal; Antilymphocyte Serum; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Chemoradiotherapy; Dacarbazine; Female; Glioblastoma; Horses; Humans; Middle Aged; Myocarditis; Nivolumab; Temozolomide | 2017 |
Feasibility and safety of extended adjuvant temozolomide beyond six cycles for patients with glioblastoma.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemoradiotherapy; Chemotherapy, Adjuvant; Dacarbazine; Disease-Free Survival; Drug Administration Schedule; Feasibility Studies; Female; Glioblastoma; Hong Kong; Humans; Male; Middle Aged; Registries; Retrospective Studies; Temozolomide | 2017 |
AAV-mediated direct in vivo CRISPR screen identifies functional suppressors in glioblastoma.
Topics: Animals; Brain Neoplasms; Cells, Cultured; CRISPR-Cas Systems; Dacarbazine; Dependovirus; DNA Mutational Analysis; Female; Gene Knock-In Techniques; Gene Knockout Techniques; Glioblastoma; Humans; Male; Mice; Mutation; Suppression, Genetic; Temozolomide; Transcriptome | 2017 |
Blastomycosis and Histoplasmosis in a Patient with Glioblastoma Receiving Temozolomide.
Topics: Antineoplastic Agents, Alkylating; Blastomycosis; Brain Neoplasms; Chemotherapy, Adjuvant; Dacarbazine; Glioblastoma; Histoplasmosis; Humans; Lung Diseases, Fungal; Male; Middle Aged; Opportunistic Infections; Radiotherapy, Adjuvant; Temozolomide | 2016 |
Specificity protein 1-modulated superoxide dismutase 2 enhances temozolomide resistance in glioblastoma, which is independent of O
Topics: Animals; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; Drug Resistance, Neoplasm; Glioblastoma; Humans; Male; Mice; Mice, Inbred NOD; Mice, SCID; Reactive Oxygen Species; Sp1 Transcription Factor; Superoxide Dismutase; Temozolomide; Tumor Suppressor Proteins | 2017 |
Genetic driver mutations define the expression signature and microenvironmental composition of high-grade gliomas.
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Cerebral Ventricles; Dacarbazine; Disease Models, Animal; Doublecortin Domain Proteins; Gene Expression Regulation, Neoplastic; Glioma; Humans; Hyaluronan Receptors; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microtubule-Associated Proteins; Mutation; Nestin; Neurofibromin 1; Neuropeptides; Proto-Oncogene Proteins c-sis; PTEN Phosphohydrolase; RNA, Small Interfering; Temozolomide | 2017 |
Induction of Mitochondrial Dysfunction and Oxidative Damage by Antibiotic Drug Doxycycline Enhances the Responsiveness of Glioblastoma to Chemotherapy.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Dacarbazine; Doxycycline; Drug Synergism; Glioblastoma; Humans; Membrane Potential, Mitochondrial; Mice; Mitochondria; Oxidative Stress; Random Allocation; Reactive Oxygen Species; Temozolomide; Xenograft Model Antitumor Assays | 2017 |
Evaluation of drug combination for glioblastoma based on an intestine-liver metabolic model on microchip.
Topics: Antineoplastic Agents; Apoptosis; Brain Neoplasms; Caco-2 Cells; Coculture Techniques; Cyclophosphamide; Dacarbazine; Drug Combinations; Drug Delivery Systems; Glioblastoma; Hep G2 Cells; Humans; Intestinal Absorption; Intestines; Irinotecan; Liver; Models, Biological | 2017 |
[Corticosteroids compromise survival in glioblastoma patients after radio- and chemotherapy].
Topics: Adrenal Cortex Hormones; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Glioblastoma; Humans | 2017 |
The use of TMZ embedded hydrogels for the treatment of orthotopic human glioma xenografts.
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; Disease Models, Animal; Glioblastoma; Glioma; Humans; Hydrogels; Mice; Neoplasm Recurrence, Local; Temozolomide; Xenograft Model Antitumor Assays | 2017 |
Phase I/II Trial of Combination of Temozolomide Chemotherapy and Immunotherapy With Fusions of Dendritic and Glioma Cells in Patients With Glioblastoma.
Topics: Brain Neoplasms; Dacarbazine; Glioblastoma; Glioma; Humans; Immunotherapy; Temozolomide | 2017 |
Zika virus has oncolytic activity against glioblastoma stem cells.
Topics: Animals; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Chlorocebus aethiops; Combined Modality Therapy; Dacarbazine; Female; Fluorescent Antibody Technique; Glioblastoma; Humans; Mice; Mice, Inbred C57BL; Neoplasms, Experimental; Neoplastic Stem Cells; Oncolytic Virotherapy; Temozolomide; Vero Cells; Zika Virus | 2017 |
Prognostic importance of temozolomide-induced neutropenia in glioblastoma, IDH-wildtype patients.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Female; Glioblastoma; Humans; Isocitrate Dehydrogenase; Karnofsky Performance Status; Male; Middle Aged; Neutropenia; Prognosis; Proportional Hazards Models; Retrospective Studies; Temozolomide; Treatment Outcome | 2018 |
Significance of perivascular tumour cells defined by CD109 expression in progression of glioma.
Topics: Animals; Antigens, CD; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Proliferation; Dacarbazine; Disease Progression; Gene Expression Regulation, Neoplastic; Glioma; GPI-Linked Proteins; Humans; Mice; Mice, Knockout; Neoplasm Proteins; Neoplastic Stem Cells; Signal Transduction; Temozolomide; Time Factors; Tumor Cells, Cultured; Tumor Microenvironment | 2017 |
MicroRNA-132 induces temozolomide resistance and promotes the formation of cancer stem cell phenotypes by targeting tumor suppressor candidate 3 in glioblastoma.
Topics: 3' Untranslated Regions; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Membrane Proteins; MicroRNAs; Neoplastic Stem Cells; Phenotype; RNA Interference; RNA, Messenger; Temozolomide; Tumor Suppressor Proteins | 2017 |
Identification of WISP1 as a novel oncogene in glioblastoma.
Topics: Brain Neoplasms; CCN Intercellular Signaling Proteins; Cell Line, Tumor; Cell Movement; Cell Proliferation; Dacarbazine; Drug Resistance, Neoplasm; Female; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Male; Neoplasm Staging; Prognosis; Proto-Oncogene Proteins; Temozolomide; Up-Regulation | 2017 |
Temozolomide resistant human brain tumor stem cells are susceptible to recombinant vesicular stomatitis virus and double-deleted Vaccinia virus in vitro.
Topics: Brain Neoplasms; Cell Death; Cell Differentiation; Cell Self Renewal; Dacarbazine; Drug Resistance, Neoplasm; Humans; Neoplastic Stem Cells; Recombination, Genetic; Temozolomide; Vaccinia virus; Vesicular Stomatitis; Virus Replication | 2017 |
Impact of mesenchymal stem cells' secretome on glioblastoma pathophysiology.
Topics: Brain Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Culture Media, Conditioned; Dacarbazine; Gene Expression Regulation, Neoplastic; Glioblastoma; Human Umbilical Vein Endothelial Cells; Humans; Mesenchymal Stem Cells; Proteome; Temozolomide | 2017 |
HB-EGF is associated with DNA damage and Mcl-1 turnover in human glioma cell lines treated by Temozolomide.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; DNA Breaks, Double-Stranded; DNA Repair; Drug Resistance, Neoplasm; Gene Knockdown Techniques; Glioblastoma; Heparin-binding EGF-like Growth Factor; Histones; Humans; Myeloid Cell Leukemia Sequence 1 Protein; Proteolysis; RNA, Messenger; RNA, Neoplasm; Temozolomide; Ubiquitin Thiolesterase | 2017 |
Concurrent radiotherapy with temozolomide vs. concurrent radiotherapy with a cisplatinum-based polychemotherapy regimen : Acute toxicity in pediatric high-grade glioma patients.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Chemoradiotherapy; Child; Child, Preschool; Cisplatin; Cohort Studies; Dacarbazine; Etoposide; Female; Glioma; Humans; Ifosfamide; Leukopenia; Male; Neoplasm Grading; Prospective Studies; Temozolomide; Treatment Outcome; Vincristine | 2018 |
Dynamic stroma reorganization drives blood vessel dysmorphia during glioma growth.
Topics: Animals; Antibodies, Monoclonal; Antineoplastic Agents, Alkylating; Blood Vessels; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; Disease Models, Animal; Female; Glioma; Humans; Macrophage Colony-Stimulating Factor; Macrophages; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neovascularization, Pathologic; Phenotype; Proto-Oncogene Proteins c-sis; Temozolomide; Vascular Endothelial Growth Factor A | 2017 |
Hyperthermia with different temperatures inhibits proliferation and promotes apoptosis through the EGFR/STAT3 pathway in C6 rat glioma cells.
Topics: Animals; Apoptosis; Brain Neoplasms; Carcinogenesis; Cell Line, Tumor; Cell Proliferation; Dacarbazine; ErbB Receptors; Glioma; Human Umbilical Vein Endothelial Cells; Humans; Hyperthermia, Induced; Rats, Wistar; Reference Standards; Signal Transduction; STAT3 Transcription Factor; Temozolomide; Temperature | 2017 |
Sequential proton boost after standard chemoradiation for high-grade glioma.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemoradiotherapy, Adjuvant; Dacarbazine; Disease Progression; Disease-Free Survival; Glioma; Humans; Male; Middle Aged; Neoplasm Grading; Proton Therapy; Retrospective Studies; Temozolomide; Young Adult | 2017 |
Epidermal Growth Factor Receptor Expression Predicts Time and Patterns of Recurrence in Patients with Glioblastoma After Radiotherapy and Temozolomide.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Biomarkers, Tumor; Brain Neoplasms; Dacarbazine; Databases, Factual; ErbB Receptors; Female; Follow-Up Studies; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Predictive Value of Tests; Radiotherapy; Retrospective Studies; Temozolomide; Treatment Outcome | 2018 |
Comparison between the Prebolus T1 Measurement and the Fixed T1 Value in Dynamic Contrast-Enhanced MR Imaging for the Differentiation of True Progression from Pseudoprogression in Glioblastoma Treated with Concurrent Radiation Therapy and Temozolomide Che
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemoradiotherapy; Contrast Media; Dacarbazine; Disease Progression; Female; Glioblastoma; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Multivariate Analysis; Reproducibility of Results; Retrospective Studies; ROC Curve; Sensitivity and Specificity; Temozolomide | 2017 |
Clinical and economic evaluation of modulated electrohyperthermia concurrent to dose-dense temozolomide 21/28 days regimen in the treatment of recurrent glioblastoma: a retrospective analysis of a two-centre German cohort trial with systematic comparison
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cost-Benefit Analysis; Dacarbazine; Female; Germany; Glioblastoma; Humans; Hyperthermia, Induced; Male; Middle Aged; Neoplasm Recurrence, Local; Quality-Adjusted Life Years; Regression Analysis; Retrospective Studies; Temozolomide | 2017 |
Increased signal intensity within glioblastoma resection cavities on fluid-attenuated inversion recovery imaging to detect early progressive disease in patients receiving radiotherapy with concomitant temozolomide therapy.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Disease Progression; Female; Glioblastoma; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Retrospective Studies; Sensitivity and Specificity; Temozolomide | 2018 |
Comparative assessment of three methods to analyze MGMT methylation status in a series of 350 gliomas and gangliogliomas.
Topics: Adult; Aged; Brain Neoplasms; Dacarbazine; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Female; Ganglioglioma; Glioblastoma; Glioma; Humans; Male; Middle Aged; Promoter Regions, Genetic; Temozolomide; Tumor Suppressor Proteins | 2017 |
Glutathione reductase mediates drug resistance in glioblastoma cells by regulating redox homeostasis.
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Buthionine Sulfoximine; Cell Line, Tumor; Cisplatin; Dacarbazine; Disease-Free Survival; Drug Resistance, Neoplasm; Female; Gene Knockdown Techniques; Glioblastoma; Glutathione; Glutathione Reductase; Homeostasis; Humans; Mice; Mice, Inbred BALB C; Neoplasm Proteins; Oxidants; Oxidation-Reduction; Oxidative Stress; Reactive Oxygen Species; RNA, Small Interfering; Temozolomide; Tumor Stem Cell Assay; Xenograft Model Antitumor Assays | 2018 |
Tramadol attenuates the sensitivity of glioblastoma to temozolomide through the suppression of Cx43‑mediated gap junction intercellular communication.
Topics: Analgesics, Opioid; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Communication; Cell Line, Tumor; Connexin 43; Dacarbazine; Drug Interactions; Gap Junctions; Glioblastoma; Humans; Temozolomide; Tramadol; Transfection | 2018 |
FTY720 inhibits the Nrf2/ARE pathway in human glioblastoma cell lines and sensitizes glioblastoma cells to temozolomide.
Topics: Antineoplastic Agents, Alkylating; Antioxidant Response Elements; Apoptosis; Autophagy; Brain Neoplasms; Cell Line, Tumor; Cell Survival; Dacarbazine; Drug Resistance, Neoplasm; Fingolimod Hydrochloride; Gene Knockdown Techniques; Glioblastoma; Heme Oxygenase-1; Humans; NF-E2-Related Factor 2; RNA, Messenger; RNA, Small Interfering; Temozolomide | 2017 |
Upregulation of CASC2 sensitized glioma to temozolomide cytotoxicity through autophagy inhibition by sponging miR-193a-5p and regulating mTOR expression.
Topics: Antineoplastic Agents, Alkylating; Apoptosis; Autophagy; Brain Neoplasms; Cell Line, Tumor; Cell Survival; Dacarbazine; Down-Regulation; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Glioma; Humans; MicroRNAs; Temozolomide; TOR Serine-Threonine Kinases; Tumor Suppressor Proteins; Up-Regulation | 2018 |
Injectable Hydrogels for Localized Chemotherapy and Radiotherapy in Brain Tumors.
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Cell Line, Tumor; Combined Modality Therapy; Dacarbazine; Disease Progression; Female; Glioblastoma; Humans; Hydrogels; Injections; Iodine Radioisotopes; Male; Mice; Mice, Nude; Prognosis; Temozolomide | 2018 |
Modelling glioblastoma tumour-host cell interactions using adult brain organotypic slice co-culture.
Topics: Aging; Animals; Antigens, CD; Biomarkers, Tumor; Brain; Brain Neoplasms; Cell Communication; Cell Proliferation; Coculture Techniques; Culture Media, Serum-Free; Cytarabine; Dacarbazine; Disease Models, Animal; Endothelial Cells; Glioblastoma; Humans; Mice, Inbred C57BL; Neoplastic Stem Cells; Neural Stem Cells; Organ Specificity; Stem Cell Niche; Temozolomide; Tumor Microenvironment; Xenograft Model Antitumor Assays | 2018 |
MRI to MGMT: predicting methylation status in glioblastoma patients using convolutional recurrent neural networks.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Computational Biology; Dacarbazine; Databases, Genetic; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Drug Resistance, Neoplasm; Glioblastoma; Humans; Magnetic Resonance Imaging; Neural Networks, Computer; Regulatory Sequences, Nucleic Acid; Temozolomide; Tumor Suppressor Proteins | 2018 |
Farewell to monomodality treatment in patients with WHO lower grade glioma?
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemoradiotherapy; Clinical Trials, Phase III as Topic; Dacarbazine; Female; Glioma; Humans; Male; Neoplasm Grading; Radiotherapy; Randomized Controlled Trials as Topic; Temozolomide | 2018 |
Anticancer activity of osmium(VI) nitrido complexes in patient-derived glioblastoma initiating cells and in vivo mouse models.
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Cell Line, Tumor; Cell Survival; Cisplatin; Coordination Complexes; Dacarbazine; Female; Glioblastoma; HeLa Cells; Humans; Kaplan-Meier Estimate; Mice, Nude; Neoplastic Stem Cells; Osmium; Temozolomide; Xenograft Model Antitumor Assays | 2018 |
Calvarium mass as the first presentation of glioblastoma multiforme: A very rare manifestation of high-grade glioma.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Frontal Lobe; Glioblastoma; Humans; Male; Middle Aged; Skull; Skull Neoplasms; Temozolomide | 2018 |
The JAK2/STAT3 inhibitor pacritinib effectively inhibits patient-derived GBM brain tumor initiating cells in vitro and when used in combination with temozolomide increases survival in an orthotopic xenograft model.
Topics: Animals; Apoptosis; Blood-Brain Barrier; Brain Neoplasms; Bridged-Ring Compounds; Cell Proliferation; Cell Survival; Dacarbazine; Disease Progression; Female; Glioblastoma; Humans; Janus Kinase 2; Male; Mice; Mice, SCID; Microsomes, Liver; Permeability; Pyrimidines; STAT3 Transcription Factor; Temozolomide; Treatment Outcome; Xenograft Model Antitumor Assays | 2017 |
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Dihydroxyphenylalanine; Female; Glioma; Humans; Male; Middle Aged; Neoplasm Grading; Positron Emission Tomography Computed Tomography; Radiographic Image Interpretation, Computer-Assisted; Radiopharmaceuticals; Retrospective Studies; Temozolomide; Tumor Burden | 2018 |
Differential Characterization of Temozolomide-Resistant Human Glioma Cells.
Topics: Brain Neoplasms; Cell Adhesion; Cell Line, Tumor; Cell Movement; Connexin 43; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Glioma; Humans; Monocytes; Temozolomide; Tumor Necrosis Factor-alpha; Tumor Suppressor Proteins; Up-Regulation; Vascular Cell Adhesion Molecule-1 | 2018 |
Aldehyde dehydrogenase 1A3 (ALDH1A3) is regulated by autophagy in human glioblastoma cells.
Topics: Aldehyde Oxidoreductases; Antineoplastic Agents, Alkylating; Autophagy; Brain Neoplasms; Cell Line, Tumor; Cell Survival; Dacarbazine; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Mutation; Protein Binding; Sequestosome-1 Protein; Temozolomide | 2018 |
Ultrasonography, a useful tool for detecting tumour 'pseudoprogression'.
Topics: Antibodies, Monoclonal; Brain Neoplasms; Dacarbazine; Humans; Nivolumab; Ultrasonography | 2017 |
Temozolomide-induced increase of tumorigenicity can be diminished by targeting of mitochondria in in vitro models of patient individual glioblastoma.
Topics: Anti-Bacterial Agents; Antineoplastic Agents, Alkylating; Biomarkers, Tumor; Brain Neoplasms; Cell Differentiation; Cell Line, Tumor; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; Doxycycline; Drug Resistance, Neoplasm; Fucosyltransferases; Glioblastoma; Humans; Lewis X Antigen; Mitochondria; Neoplastic Stem Cells; Nestin; Temozolomide; Tumor Stem Cell Assay; Tumor Suppressor Proteins | 2018 |
NKG2D ligands in glioma stem-like cells: expression in situ and in vitro.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Differentiation; Dacarbazine; Female; Glioma; Humans; Ligands; Male; Middle Aged; NK Cell Lectin-Like Receptor Subfamily K; Temozolomide; Tumor Cells, Cultured | 2018 |
Up-regulation of MSH6 is associated with temozolomide resistance in human glioblastoma.
Topics: Adult; Antineoplastic Agents, Alkylating; Apoptosis; Brain Neoplasms; Dacarbazine; DNA-Binding Proteins; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Female; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Male; Middle Aged; Temozolomide; Treatment Outcome; Tumor Cells, Cultured; Up-Regulation | 2018 |
Photon vs. proton radiochemotherapy: Effects on brain tissue volume and perfusion.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain; Brain Neoplasms; Cerebrovascular Circulation; Chemoradiotherapy; Dacarbazine; Female; Glioblastoma; Gray Matter; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Multivariate Analysis; Photons; Proton Therapy; Temozolomide; White Matter; Young Adult | 2018 |
Chemotherapy of Diffuse Astrocytoma (WHO grade II) in Adults.
Topics: Adult; Astrocytoma; Brain Neoplasms; Chemotherapy, Adjuvant; Dacarbazine; Glioma; Humans; Procarbazine; Temozolomide | 2018 |
Chemotherapy of Oligodendrogliomas.
Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Chemotherapy, Adjuvant; Dacarbazine; Glioma; Humans; Oligodendroglioma; Temozolomide | 2018 |
Interference with PSMB4 Expression Exerts an Anti-Tumor Effect by Decreasing the Invasion and Proliferation of Human Glioblastoma Cells.
Topics: Animals; Apoptosis; Brain Neoplasms; Cathepsin B; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Movement; Cell Proliferation; Dacarbazine; Databases, Factual; Glioblastoma; Humans; Ki-67 Antigen; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Grading; Proteasome Endopeptidase Complex; RNA Interference; Temozolomide | 2018 |
Is MGMT promoter methylation to be considered in the decision making for recurrent surgery in glioblastoma patients?
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Biomarkers, Tumor; Brain Neoplasms; Dacarbazine; Decision Making; Disease-Free Survival; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Female; Glioblastoma; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Promoter Regions, Genetic; Tumor Suppressor Proteins | 2018 |
NEO212 Inhibits Migration and Invasion of Glioma Stem Cells.
Topics: Animals; Brain Neoplasms; Cell Line, Tumor; Cell Movement; Dacarbazine; Drug Resistance, Neoplasm; Epithelial-Mesenchymal Transition; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Glioma; Male; Mice, Inbred NOD; Mice, SCID; Neoplasm Invasiveness; Neoplastic Stem Cells; Survival Analysis; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2018 |
A primitive neuroectodermal tumor in an adult: Case report of a unique location and MRI characteristics.
Topics: Adult; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cerebral Ventricles; Chemotherapy, Adjuvant; Dacarbazine; Humans; Magnetic Resonance Imaging; Male; Neuroectodermal Tumors, Primitive; Temozolomide; Treatment Outcome | 2018 |
Advantages and Disadvantages of Combined Chemotherapy with Carmustine Wafer and Bevacizumab in Patients with Newly Diagnosed Glioblastoma: A Single-Institutional Experience.
Topics: Adult; Aged; Angiogenesis Inhibitors; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Brain Neoplasms; Carmustine; Combined Modality Therapy; Cranial Irradiation; Craniotomy; Cysts; Dacarbazine; Disease-Free Survival; Drug Administration Schedule; Drug Evaluation; Drug Implants; Drug Synergism; Female; Follow-Up Studies; Glioblastoma; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Neoplasm Recurrence, Local; Neurosurgical Procedures; Postoperative Hemorrhage; Proportional Hazards Models; Retrospective Studies; Temozolomide; Treatment Outcome; Tumor Microenvironment | 2018 |
A HIF-independent, CD133-mediated mechanism of cisplatin resistance in glioblastoma cells.
Topics: AC133 Antigen; Basic Helix-Loop-Helix Transcription Factors; Brain Neoplasms; Cell Line, Tumor; Cisplatin; Dacarbazine; Drug Resistance, Neoplasm; Etoposide; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; RNA, Messenger; Temozolomide; Tumor Hypoxia; Vascular Endothelial Growth Factors | 2018 |
Tumor Volume Changes During and After Temozolomide Treatment for Newly Diagnosed Higher-Grade Glioma (III and IV).
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Female; Glioma; Humans; Male; Middle Aged; Retrospective Studies; Temozolomide; Tumor Burden | 2018 |
Characterizing the molecular mechanisms of acquired temozolomide resistance in the U251 glioblastoma cell line by protein microarray.
Topics: Apoptosis; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Dacarbazine; Drug Resistance, Neoplasm; G2 Phase Cell Cycle Checkpoints; Gene Expression Regulation, Neoplastic; Gene Regulatory Networks; Glioblastoma; Humans; Protein Array Analysis; Protein Interaction Maps; src-Family Kinases; Temozolomide | 2018 |
A Comparative Analysis of the Usefulness of Survival Prediction Models for Patients with Glioblastoma in the Temozolomide Era: The Importance of Methylguanine Methyltransferase Promoter Methylation, Extent of Resection, and Subventricular Zone Location.
Topics: Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemoradiotherapy; Combined Modality Therapy; Dacarbazine; DNA Methylation; DNA Modification Methylases; Female; Glioblastoma; Humans; Lateral Ventricles; Male; Methyltransferases; Middle Aged; Temozolomide; Tumor Suppressor Proteins | 2018 |
Identification of Key Candidate Proteins and Pathways Associated with Temozolomide Resistance in Glioblastoma Based on Subcellular Proteomics and Bioinformatical Analysis.
Topics: Biomarkers, Tumor; Brain Neoplasms; Cell Line, Tumor; Computational Biology; Dacarbazine; Down-Regulation; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Neoplasm Proteins; Proteomics; Ribosomal Protein L3; Signal Transduction; Temozolomide; Up-Regulation | 2018 |
Receptor-mediated PLGA nanoparticles for glioblastoma multiforme treatment.
Topics: Antibodies, Monoclonal; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Dacarbazine; Dose-Response Relationship, Drug; Drug Carriers; Drug Compounding; Drug Liberation; Glioblastoma; Humans; Kinetics; Lactic Acid; Nanoparticles; Nanotechnology; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Receptors, Transferrin; Technology, Pharmaceutical; Temozolomide | 2018 |
Temozolomide rechallenge in recurrent glioblastoma: when is it useful?
Topics: Adult; Aged; Brain Neoplasms; Dacarbazine; Disease-Free Survival; Female; Glioblastoma; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Neoplasm Recurrence, Local; Temozolomide; Treatment Outcome | 2018 |
Overexpression of Fn14 in gliomas: tumor progression and poor prognosis.
Topics: Antineoplastic Agents, Alkylating; Biomarkers, Tumor; Brain; Brain Neoplasms; Cell Line, Tumor; Chemoradiotherapy, Adjuvant; Dacarbazine; Datasets as Topic; Disease-Free Survival; DNA Methylation; Down-Regulation; Gene Expression Regulation, Neoplastic; Glioma; Humans; Isocitrate Dehydrogenase; Mutation; Neoplasm Grading; Prognosis; Temozolomide; TWEAK Receptor | 2018 |
Temozolomide combined with PD-1 Antibody therapy for mouse orthotopic glioma model.
Topics: Animals; Antibodies, Neoplasm; Brain; Brain Neoplasms; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cell Line, Tumor; Cell Proliferation; Combined Modality Therapy; Dacarbazine; Disease Models, Animal; Glioma; Humans; Male; Mice, Inbred C57BL; Programmed Cell Death 1 Receptor; Temozolomide; Tumor Burden | 2018 |
[Clinical efficacy of stereotactic radiation therapy combined with temozolomide on recurrent brain glioma].
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemoradiotherapy; Combined Modality Therapy; Dacarbazine; Glioma; Humans; Neoplasm Recurrence, Local; Radiosurgery; Retrospective Studies; Survival Rate; Temozolomide; Treatment Outcome | 2018 |
Regulation of the oxidative balance with coenzyme Q10 sensitizes human glioblastoma cells to radiation and temozolomide.
Topics: Antioxidants; Apoptosis; Brain Neoplasms; Dacarbazine; DNA Damage; Glioblastoma; Humans; Hydrogen Peroxide; Mitochondria; Oxidative Stress; Oxygen Consumption; Radiation Tolerance; Reactive Oxygen Species; Temozolomide; Tumor Cells, Cultured; Ubiquinone | 2018 |
Superselective intraarterial cerebral infusion of cetuximab with blood brain barrier disruption combined with Stupp Protocol for newly diagnosed glioblastoma.
Topics: Angiography, Digital Subtraction; Antineoplastic Agents, Alkylating; Antineoplastic Agents, Immunological; Blood-Brain Barrier; Brain Neoplasms; Cerebral Angiography; Cetuximab; Chemoradiotherapy, Adjuvant; Chemotherapy, Adjuvant; Craniotomy; Dacarbazine; Dose Fractionation, Radiation; Female; Glioblastoma; Humans; Infusions, Intra-Arterial; Magnetic Resonance Imaging; Mannitol; Middle Aged; Temozolomide; Treatment Outcome | 2018 |
Treatment outcomes of hypofractionated radiotherapy combined with temozolomide followed by bevacizumab salvage therapy in glioblastoma patients aged > 75 years.
Topics: Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Brain Neoplasms; Chemoradiotherapy; Dacarbazine; Dose Fractionation, Radiation; Female; Glioblastoma; Humans; Male; Retrospective Studies; Salvage Therapy; Survival Rate; Temozolomide; Treatment Outcome | 2018 |
Memory and attention recovery in patients with High Grade Glioma who completed the Stupp protocol: A before-after study.
Topics: Adult; Aged; Attention; Brain Neoplasms; Cognition; Combined Modality Therapy; Dacarbazine; Female; Glioblastoma; Glioma; Humans; Male; Memory; Middle Aged; Temozolomide; Treatment Outcome | 2018 |
Identification of a DNA Repair-Related Multigene Signature as a Novel Prognostic Predictor of Glioblastoma.
Topics: Adenine Phosphoribosyltransferase; Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; DNA Mismatch Repair; DNA Repair; DNA-(Apurinic or Apyrimidinic Site) Lyase; Female; Genes, Neoplasm; Genetic Markers; Glioblastoma; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Mismatch Repair Endonuclease PMS2; Poly(ADP-ribose) Polymerases; Prospective Studies; RNA Polymerase II; RNA, Messenger; Temozolomide | 2018 |
Lactoferrin- and RGD-comodified, temozolomide and vincristine-coloaded nanostructured lipid carriers for gliomatosis cerebri combination therapy.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; Drug Carriers; Drug Delivery Systems; Drug Liberation; Humans; Lactoferrin; Lipids; Mice, Inbred BALB C; Nanostructures; Neoplasms, Neuroepithelial; Oligopeptides; Temozolomide; Tissue Distribution; Vincristine; Xenograft Model Antitumor Assays | 2018 |
Improved survival of Swedish glioblastoma patients treated according to Stupp.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cohort Studies; Combined Modality Therapy; Dacarbazine; Female; Glioblastoma; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Survival Rate; Sweden; Temozolomide | 2018 |
[Establishment of a glioma orthotopic xenograft model based on imaging technology].
Topics: Animals; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; Disease Models, Animal; Glioma; Heterografts; Humans; Magnetic Resonance Imaging; Mice; Mice, Inbred BALB C; Mice, Nude; Temozolomide; Xenograft Model Antitumor Assays | 2016 |
Combination with TMZ and miR-505 inhibits the development of glioblastoma by regulating the WNT7B/Wnt/β-catenin signaling pathway.
Topics: Animals; Antineoplastic Agents, Alkylating; Base Sequence; beta Catenin; Binding Sites; Brain Neoplasms; Carcinogenesis; Cell Line, Tumor; Combined Modality Therapy; Dacarbazine; Gene Expression; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Mice, Nude; MicroRNAs; RNA Interference; Temozolomide; Wnt Proteins; Wnt Signaling Pathway; Xenograft Model Antitumor Assays | 2018 |
Genetic variants related to angiogenesis and apoptosis in patients with glioma.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Apoptosis; Brain Neoplasms; Child; Child, Preschool; Combined Modality Therapy; Dacarbazine; Female; Genotype; Glioma; Humans; Infant; Kaplan-Meier Estimate; Life Style; Male; Middle Aged; Neovascularization, Pathologic; Polymorphism, Genetic; Real-Time Polymerase Chain Reaction; Temozolomide; Young Adult | 2018 |
Verapamil potentiates anti-glioblastoma efficacy of temozolomide by modulating apoptotic signaling.
Topics: Antineoplastic Agents, Alkylating; Apoptosis; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; Drug Synergism; Glioblastoma; Humans; Proto-Oncogene Proteins c-bcl-2; RNA, Messenger; Signal Transduction; Temozolomide; Verapamil | 2018 |
Pyr3 Induces Apoptosis and Inhibits Migration in Human Glioblastoma Cells.
Topics: Animals; Apoptosis; Brain Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Dacarbazine; Databases, Factual; Focal Adhesion Protein-Tyrosine Kinases; Glioblastoma; Humans; Membrane Potential, Mitochondrial; Mice; Mice, Inbred BALB C; Mice, Nude; Myosin Light Chains; Phosphorylation; Pyrazoles; Temozolomide; Transplantation, Heterologous; TRPC Cation Channels | 2018 |
A Novel Tumor-Suppressor, CDH18, Inhibits Glioma Cell Invasiveness Via UQCRC2 and Correlates with the Prognosis of Glioma Patients.
Topics: Aged; Animals; Biomarkers, Tumor; Brain Neoplasms; Cadherins; Cell Line, Tumor; Cell Movement; Cell Proliferation; Dacarbazine; Drug Resistance, Neoplasm; Electron Transport Complex III; Gene Expression Regulation, Neoplastic; Glioma; Humans; Mice; Mice, Nude; Middle Aged; Mitochondrial Proteins; Prognosis; RNA Interference; RNA, Small Interfering; Temozolomide | 2018 |
MAPK8 mediates resistance to temozolomide and apoptosis of glioblastoma cells through MAPK signaling pathway.
Topics: Antineoplastic Agents, Alkylating; Apoptosis; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Computational Biology; Dacarbazine; Databases, Genetic; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Gene Regulatory Networks; Glioblastoma; Humans; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 8; Protein Interaction Maps; Temozolomide | 2018 |
MIM1, the Mcl-1 - specific BH3 mimetic induces apoptosis in human U87MG glioblastoma cells.
Topics: Antineoplastic Agents, Alkylating; Apoptosis; Brain Neoplasms; Cell Cycle; Cell Line, Tumor; Cell Survival; Dacarbazine; DNA Damage; Dose-Response Relationship, Drug; Glioblastoma; Humans; Membrane Potential, Mitochondrial; Myeloid Cell Leukemia Sequence 1 Protein; Temozolomide; Thiazoles | 2018 |
Cell Subpopulations Overexpressing p75NTR Have Tumor-initiating Properties in the C6 Glioma Cell Line.
Topics: Animals; Biomarkers, Tumor; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dacarbazine; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Glioma; Humans; Neoplasm Transplantation; Neoplastic Stem Cells; Nerve Tissue Proteins; Radiotherapy; Rats; Rats, Sprague-Dawley; Receptors, Nerve Growth Factor; Temozolomide; Up-Regulation | 2018 |
Juniperus Communis Extract Exerts Antitumor Effects in Human Glioblastomas Through Blood-Brain Barrier.
Topics: Animals; Apoptosis; Blood-Brain Barrier; Brain Neoplasms; Caspase 3; Cell Cycle Checkpoints; Cell Line, Tumor; Dacarbazine; Drug Synergism; Female; Glioblastoma; Humans; Juniperus; Mice; Mice, Inbred BALB C; Mice, Nude; Plant Extracts; Proliferating Cell Nuclear Antigen; Temozolomide; Vascular Endothelial Growth Factor Receptor-1; Vascular Endothelial Growth Factor Receptor-2 | 2018 |
NEO212, a conjugate of temozolomide and perillyl alcohol, blocks the endothelial-to-mesenchymal transition in tumor-associated brain endothelial cells in glioblastoma.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cell Line, Tumor; Cell Movement; Coculture Techniques; Dacarbazine; Endothelial Cells; Epithelial-Mesenchymal Transition; Glioblastoma; Humans; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mice, Nude; Neoplasm Invasiveness; Neovascularization, Pathologic; Receptors, Notch; Signal Transduction; Transforming Growth Factor beta; Xenograft Model Antitumor Assays | 2019 |
Chemotherapy sensitization of glioblastoma by focused ultrasound-mediated delivery of therapeutic liposomes.
Topics: Animals; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; Drug Delivery Systems; Enzyme Inhibitors; Glioblastoma; Guanine; Liposomes; Magnetic Resonance Imaging; Mice; O(6)-Methylguanine-DNA Methyltransferase; Ultrasonic Waves | 2019 |
Topics: Adult; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; Glioblastoma; Humans; Neoplastic Stem Cells; Silicon Dioxide; Temozolomide | 2019 |
MAID chemotherapy regimen as a treatment strategy for metastatic malignant ameloblastoma: A case report.
Topics: Adult; Ameloblastoma; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Dacarbazine; Disease-Free Survival; Doxorubicin; Female; Humans; Ifosfamide; Jaw Neoplasms; Lung Neoplasms; Mesna; Neoplasm Metastasis; Neoplasm Recurrence, Local; Treatment Outcome | 2019 |
Is a reduction of radiation dose feasible in patients affected by glioblastoma undergoing radio-chemotherapy according to MGMT promoter methylation status without jeopardizing survival?
Topics: Adult; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemoradiotherapy; Dacarbazine; DNA Modification Methylases; Female; Glioblastoma; Humans; Male; Middle Aged | 2019 |
MELK-dependent FOXM1 phosphorylation is essential for proliferation of glioma stem cells.
Topics: Animals; Brain Neoplasms; Cell Cycle Proteins; Cell Proliferation; Cells, Cultured; Dacarbazine; Forkhead Transcription Factors; Glioblastoma; HEK293 Cells; Humans; Mice; Mitosis; Neoplastic Stem Cells; Neural Stem Cells; Peptides; Phosphorylation; Polo-Like Kinase 1; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Temozolomide; Up-Regulation | 2013 |
Reversing the Warburg effect as a treatment for glioblastoma.
Topics: Adenosine Triphosphate; Animals; Annexin A5; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Dacarbazine; Energy Metabolism; Female; Glioblastoma; Humans; Lactates; Methylene Blue; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Oxygen Consumption; Structure-Activity Relationship; Temozolomide; Tolonium Chloride | 2013 |
Morphologic MRI features, diffusion tensor imaging and radiation dosimetric analysis to differentiate pseudo-progression from early tumor progression.
Topics: Antineoplastic Agents; Brain Neoplasms; Chemoradiotherapy; Dacarbazine; Diffusion Magnetic Resonance Imaging; Disease Progression; Female; Glioblastoma; Humans; Image Interpretation, Computer-Assisted; Magnetic Resonance Imaging; Male; Middle Aged; Radiometry; Radiotherapy; Temozolomide | 2013 |
The impact of sequential vs. combined radiochemotherapy with temozolomide, resection and MGMT promoter hypermethylation on survival of patients with primary glioblastoma--a single centre retrospective study.
Topics: Antineoplastic Agents, Alkylating; Antineoplastic Protocols; Biomarkers, Tumor; Brain Neoplasms; Chemoradiotherapy; Combined Modality Therapy; Dacarbazine; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Female; Glioblastoma; Humans; Male; Middle Aged; Neurosurgical Procedures; Promoter Regions, Genetic; Retrospective Studies; Temozolomide; Treatment Outcome; Tumor Suppressor Proteins | 2013 |
Treatment of children with glioblastoma with conformal radiation, temozolomide, and bevacizumab as adjuncts to surgical resection.
Topics: Adolescent; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Brain Neoplasms; Chemoradiotherapy; Child; Dacarbazine; Female; Glioblastoma; Humans; Magnetic Resonance Imaging; Male; Prognosis; Retrospective Studies; Temozolomide | 2013 |
Bilateral ptosis as initial presentation of gliomatosis cerebri: case report.
Topics: Anticonvulsants; Antineoplastic Agents, Alkylating; Blepharoptosis; Brain Neoplasms; Chemoradiotherapy; Combined Modality Therapy; Dacarbazine; Diagnosis, Differential; Diplopia; Fatal Outcome; Humans; Magnetic Resonance Imaging; Male; Neoplasms, Neuroepithelial; Neurosurgical Procedures; Seizures; Temozolomide; Young Adult | 2013 |
Prognostic factors for overall survival after radiosurgery for brain metastases from melanoma.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cohort Studies; Dacarbazine; Female; Humans; Kaplan-Meier Estimate; L-Lactate Dehydrogenase; Male; Melanoma; Middle Aged; Multivariate Analysis; Prognosis; Proportional Hazards Models; Radiosurgery; Radiotherapy; Retrospective Studies; Skin Neoplasms; Temozolomide; Young Adult | 2014 |
Inhibition of prolyl 4-hydroxylase, beta polypeptide (P4HB) attenuates temozolomide resistance in malignant glioma via the endoplasmic reticulum stress response (ERSR) pathways.
Topics: Animals; Antineoplastic Agents, Alkylating; Apoptosis; Blotting, Western; Brain Neoplasms; Cell Proliferation; Dacarbazine; Drug Resistance, Neoplasm; eIF-2 Kinase; Endoplasmic Reticulum Stress; Flow Cytometry; Glioma; Humans; Immunoenzyme Techniques; In Situ Nick-End Labeling; Male; Mice; Mice, Inbred BALB C; Neoplasm Recurrence, Local; Procollagen-Proline Dioxygenase; Protein Disulfide-Isomerases; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Small Interfering; Signal Transduction; Temozolomide | 2013 |
Patterns of care and outcome for patients with glioblastoma diagnosed during 2008-2010 in Spain.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Female; Follow-Up Studies; Glioblastoma; Humans; Male; Middle Aged; Neoplasm Grading; Practice Patterns, Physicians'; Prognosis; Retrospective Studies; Spain; Survival Rate; Temozolomide; Time Factors; Young Adult | 2013 |
Steroid management in newly diagnosed glioblastoma.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemoradiotherapy; Dacarbazine; Female; Glioblastoma; Glucocorticoids; Humans; Male; Middle Aged; Radiotherapy; Randomized Controlled Trials as Topic; Retrospective Studies; Temozolomide | 2013 |
Neoadjuvant chemotherapy may optimize the extent of resection of World Health Organization grade II gliomas: a case series of 17 patients.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents, Alkylating; Biomarkers, Tumor; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Female; Follow-Up Studies; Glioma; Humans; Male; Middle Aged; Neoadjuvant Therapy; Neoplasm Grading; Neurosurgical Procedures; Prognosis; Prospective Studies; Retrospective Studies; Survival Rate; Temozolomide; Tumor Burden; World Health Organization; Young Adult | 2013 |
Efficacy of protracted temozolomide dosing is limited in MGMT unmethylated GBM xenograft models.
Topics: Animals; Antineoplastic Agents, Alkylating; Apoptosis; Brain Neoplasms; Cell Proliferation; Dacarbazine; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Dose-Response Relationship, Drug; Glioblastoma; Humans; Immunoenzyme Techniques; Mice; Prognosis; Real-Time Polymerase Chain Reaction; Temozolomide; Tumor Cells, Cultured; Tumor Suppressor Proteins; Xenograft Model Antitumor Assays | 2013 |
Leptomeningeal and intramedullary metastases of glioblastoma multiforme in a patient reoperated during adjuvant radiochemotherapy.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemoradiotherapy, Adjuvant; Combined Modality Therapy; Dacarbazine; Female; Glioblastoma; Humans; Meningeal Neoplasms; Middle Aged; Muscle Weakness; Prognosis; Reoperation; Spinal Cord Neoplasms; Temozolomide | 2013 |
Combined temozolomide and sunitinib treatment leads to better tumour control but increased vascular resistance in O6-methylguanine methyltransferase-methylated gliomas.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cell Proliferation; Dacarbazine; DNA Methylation; DNA, Neoplasm; Glioma; Heterografts; Humans; Indoles; Male; Mice; Mice, Nude; O(6)-Methylguanine-DNA Methyltransferase; Pyrroles; Sunitinib; Temozolomide; Tumor Cells, Cultured; Vascular Resistance | 2013 |
Molecular analysis of a recurrent glioblastoma treated with bevacizumab.
Topics: Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Bevacizumab; Brain Neoplasms; Cell Transformation, Neoplastic; Dacarbazine; Fatal Outcome; Frontal Lobe; Glioblastoma; Humans; Magnetic Resonance Imaging; Male; Matrix Metalloproteinase 14; Matrix Metalloproteinase 2; Middle Aged; Neoplasm Recurrence, Local; Proto-Oncogene Proteins c-akt; Temozolomide; Vascular Endothelial Growth Factor Receptor-1; Vascular Endothelial Growth Factor Receptor-2 | 2014 |
[Regulation of MGMT and application for the therapy to attenuate the chemoresistance].
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; Drug Resistance, Neoplasm; Glioma; Humans; Temozolomide; Tumor Suppressor Proteins | 2012 |
Predictive value of the SLC22A18 protein expression in glioblastoma patients receiving temozolomide therapy.
Topics: Antineoplastic Agents; Blotting, Western; Brain Neoplasms; Dacarbazine; DNA Methylation; Female; Glioblastoma; Humans; Male; Organic Cation Transport Proteins; Polymerase Chain Reaction; Promoter Regions, Genetic; Temozolomide | 2013 |
Effect of lomeguatrib-temozolomide combination on MGMT promoter methylation and expression in primary glioblastoma tumor cells.
Topics: Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Blotting, Western; Brain Neoplasms; Cell Cycle; Cell Proliferation; Comet Assay; Dacarbazine; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; DNA, Neoplasm; Female; Flow Cytometry; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Immunoenzyme Techniques; Male; Middle Aged; Polymerase Chain Reaction; Promoter Regions, Genetic; Purines; Temozolomide; Tumor Cells, Cultured; Tumor Suppressor Proteins | 2013 |
Valproic acid use during radiation therapy for glioblastoma associated with improved survival.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Antineoplastic Agents, Alkylating; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Female; Glioblastoma; Histone Deacetylase Inhibitors; Humans; Male; Middle Aged; Multivariate Analysis; Retrospective Studies; Seizures; Survival Analysis; Temozolomide; Treatment Outcome; Valproic Acid; Young Adult | 2013 |
Outcomes for patients with anaplastic astrocytoma treated with chemoradiation, radiation therapy alone or radiation therapy followed by chemotherapy: a retrospective review within the era of temozolomide.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Chemoradiotherapy; Chemotherapy, Adjuvant; Dacarbazine; Female; Follow-Up Studies; Humans; Male; Middle Aged; Prognosis; Radiotherapy, Adjuvant; Retrospective Studies; Survival Rate; Temozolomide; Young Adult | 2013 |
Focused ultrasound-induced blood-brain barrier opening to enhance temozolomide delivery for glioblastoma treatment: a preclinical study.
Topics: Animals; Antineoplastic Agents, Alkylating; Blood-Brain Barrier; Brain; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; Disease Models, Animal; Drug Evaluation, Preclinical; Glioblastoma; Magnetic Resonance Imaging; Male; Rats; Sound; Temozolomide | 2013 |
Myeloablative temozolomide enhances CD8⁺ T-cell responses to vaccine and is required for efficacy against brain tumors in mice.
Topics: Animals; Antigens; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cancer Vaccines; CD8-Positive T-Lymphocytes; Cell Line, Tumor; Cell Survival; Dacarbazine; Disease Models, Animal; Immunotherapy; Interleukin-2; Lymphocyte Depletion; Lymphopenia; Mice; Mice, Transgenic; Temozolomide; Vaccines, Subunit | 2013 |
Pediatric glioblastoma with oligodendroglioma component: aggressive clinical phenotype with distinct molecular characteristics.
Topics: Brain Neoplasms; Chemoradiotherapy; Child; Dacarbazine; Fatal Outcome; Glioblastoma; Humans; Male; Microsatellite Instability; Neoplasms, Complex and Mixed; Neurosurgical Procedures; Oligodendroglioma; Phenotype; Temozolomide | 2013 |
Increased subventricular zone radiation dose correlates with survival in glioblastoma patients after gross total resection.
Topics: Adult; Aged; Aged, 80 and over; Analysis of Variance; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cerebral Ventricles; Dacarbazine; Disease-Free Survival; Female; Glioblastoma; Humans; Karnofsky Performance Status; Male; Middle Aged; Radiotherapy Dosage; Radiotherapy, Adjuvant; Radiotherapy, Intensity-Modulated; Temozolomide | 2013 |
Durable response of intracranial cellular hemangioma to bevacizumab and temozolomide.
Topics: Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Brain Neoplasms; Chemotherapy, Adjuvant; Child; Dacarbazine; Headache; Hemangioma, Capillary; Humans; Magnetic Resonance Imaging; Male; Nausea; Neoplasm Recurrence, Local; Neurosurgical Procedures; Temozolomide; Time Factors; Tomography, X-Ray Computed; Treatment Outcome; Vomiting | 2013 |
Cerebellar glioblastoma multiforme: a retrospective study of 28 patients at a single institution.
Topics: Adolescent; Adult; Age Factors; Aged; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Brain Neoplasms; Child; Dacarbazine; Disease-Free Survival; Female; Glioblastoma; Humans; Kaplan-Meier Estimate; Karnofsky Performance Status; Magnetic Resonance Imaging; Male; Middle Aged; Neoplasm Invasiveness; Neurosurgical Procedures; Prognosis; Radiosurgery; Retrospective Studies; Sex Factors; Survival Analysis; Temozolomide; Young Adult | 2013 |
MiR-139 inhibits Mcl-1 expression and potentiates TMZ-induced apoptosis in glioma.
Topics: 3' Untranslated Regions; Animals; Antineoplastic Agents, Alkylating; Apoptosis; Blotting, Western; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Dacarbazine; Glioma; Humans; Immunohistochemistry; Luciferases; Mice; Mice, Nude; MicroRNAs; Myeloid Cell Leukemia Sequence 1 Protein; Neoplasm Transplantation; Oligonucleotides; Paraffin Embedding; Plasmids; Real-Time Polymerase Chain Reaction; Temozolomide | 2013 |
Organotypic slice cultures of human glioblastoma reveal different susceptibilities to treatments.
Topics: Adult; Antineoplastic Agents, Alkylating; Apoptosis; Brain Neoplasms; Carbon; Cell Proliferation; Dacarbazine; DNA Breaks, Double-Stranded; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Glioblastoma; Humans; Organ Culture Techniques; Promoter Regions, Genetic; Temozolomide; Tumor Cells, Cultured; Tumor Suppressor Proteins; X-Rays | 2013 |
Apoptosis induction in human glioblastoma multiforme T98G cells upon temozolomide and quercetin treatment.
Topics: Antineoplastic Agents, Alkylating; Antioxidants; Apoptosis; Brain Neoplasms; Caspase 12; Caspase 3; Caspase 9; Cell Line, Tumor; Cell Survival; Cytochromes c; Dacarbazine; Endoplasmic Reticulum Stress; Enzyme Activation; Glioblastoma; Heat-Shock Proteins; HSP27 Heat-Shock Proteins; HSP72 Heat-Shock Proteins; Humans; Membrane Potential, Mitochondrial; Mitochondria; Molecular Chaperones; Quercetin; Temozolomide | 2013 |
Development of a preclinical therapeutic model of human brain metastasis with chemoradiotherapy.
Topics: Animals; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Line, Tumor; Chemoradiotherapy; Dacarbazine; Female; Green Fluorescent Proteins; Humans; Luciferases, Firefly; Mice; Mice, Nude; Neoplasms, Experimental; Radiation-Sensitizing Agents; Temozolomide; Triple Negative Breast Neoplasms | 2013 |
Relapse in medulloblastoma: what can be done after abandoning high-dose chemotherapy? A mono-institutional experience.
Topics: Administration, Intravenous; Administration, Oral; Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Camptothecin; Cerebellar Neoplasms; Child; Child, Preschool; Cisplatin; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Cranial Irradiation; Dacarbazine; Deoxycytidine; Disease Progression; Disease-Free Survival; Etoposide; Female; Gemcitabine; Humans; Irinotecan; Male; Medulloblastoma; Melphalan; Neoplasm Recurrence, Local; Organoplatinum Compounds; Oxaliplatin; Patient Selection; Quality of Life; Radiotherapy; Retrospective Studies; Salvage Therapy; Temozolomide; Young Adult | 2013 |
Caveolin-1 is a negative regulator of tumor growth in glioblastoma and modulates chemosensitivity to temozolomide.
Topics: Animals; Apoptosis; Biomarkers, Tumor; Brain Neoplasms; Caveolin 1; Cell Line, Tumor; Dacarbazine; Down-Regulation; Glioblastoma; Humans; Lentivirus; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Signal Transduction; Temozolomide; TOR Serine-Threonine Kinases; Transplantation, Heterologous | 2013 |
Concurrent bevacizumab and temozolomide alter the patterns of failure in radiation treatment of glioblastoma multiforme.
Topics: Adult; Aged; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Brain Neoplasms; Chemoradiotherapy; Dacarbazine; Disease-Free Survival; Female; Glioblastoma; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Radiotherapy, Intensity-Modulated; Retrospective Studies; Temozolomide | 2013 |
The mTOR inhibitor RAD001 potentiates autophagic cell death induced by temozolomide in a glioblastoma cell line.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Autophagy; Blotting, Western; Brain Neoplasms; Cell Proliferation; Cesium Radioisotopes; Dacarbazine; Drug Synergism; Everolimus; Flow Cytometry; Gamma Rays; Glioblastoma; Humans; Sirolimus; Temozolomide; TOR Serine-Threonine Kinases; Tumor Cells, Cultured | 2013 |
Glioma cell death induced by irradiation or alkylating agent chemotherapy is independent of the intrinsic ceramide pathway.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Death; Cell Line, Tumor; Cell Proliferation; Cell Survival; Ceramides; Clone Cells; Dacarbazine; Drug Resistance, Neoplasm; Drug Synergism; Glioma; Glucosyltransferases; Humans; Meperidine; Radiation, Ionizing; Signal Transduction; Sphingomyelin Phosphodiesterase; Temozolomide; Treatment Outcome | 2013 |
Immediate post-operative brachytherapy prior to irradiation and temozolomide for newly diagnosed glioblastoma.
Topics: Aged; Antineoplastic Agents, Alkylating; Brachytherapy; Brain Neoplasms; Case-Control Studies; Chemoradiotherapy, Adjuvant; Dacarbazine; Female; Follow-Up Studies; Glioblastoma; Humans; Male; Middle Aged; Postoperative Period; Prognosis; Survival Rate; Temozolomide | 2013 |
Defining pseudoprogression in glioblastoma multiforme.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Brain; Brain Neoplasms; Chemoradiotherapy; Dacarbazine; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Female; Glioblastoma; Humans; Incidence; Kaplan-Meier Estimate; Male; Middle Aged; Promoter Regions, Genetic; Radiation Injuries; Retrospective Studies; Risk Factors; Temozolomide; Tumor Suppressor Proteins; Young Adult | 2013 |
Effect of valproic acid on seizure control and on survival in patients with glioblastoma multiforme.
Topics: Adult; Aged; Aged, 80 and over; Anticonvulsants; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Drug Therapy, Combination; Female; Follow-Up Studies; Glioblastoma; Humans; Levetiracetam; Male; Middle Aged; Neoplasm Recurrence, Local; Piracetam; Prognosis; Retrospective Studies; Seizures; Survival Rate; Temozolomide; Valproic Acid; Young Adult | 2013 |
Activation of executioner caspases is a predictor of progression-free survival in glioblastoma patients: a systems medicine approach.
Topics: Adult; Aged; Algorithms; Antineoplastic Agents, Alkylating; Apoptosis Regulatory Proteins; Apoptotic Protease-Activating Factor 1; Brain Neoplasms; Caspase 3; Caspase 9; Caspases; Cell Survival; Dacarbazine; Disease-Free Survival; Female; Glioblastoma; Humans; Intracellular Signaling Peptides and Proteins; Male; Middle Aged; Mitochondrial Proteins; Temozolomide; X-Linked Inhibitor of Apoptosis Protein | 2013 |
Plasmablastic lymphoma after standard-dose temozolomide for newly diagnosed glioblastoma.
Topics: Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Glioblastoma; Humans; Lymphoma; Male; Temozolomide | 2013 |
Connexin43 confers Temozolomide resistance in human glioma cells by modulating the mitochondrial apoptosis pathway.
Topics: Analysis of Variance; Annexin A5; Antineoplastic Agents, Alkylating; Apoptosis; Brain Neoplasms; Cell Line, Tumor; Connexin 43; Cytochromes c; Dacarbazine; Dose-Response Relationship, Drug; Fluoresceins; Glioma; Humans; Mitochondria; Mutation; Phosphorylation; RNA, Small Interfering; Signal Transduction; Temozolomide; Time Factors; Transfection | 2013 |
Trans-1-amino-3-18F-fluorocyclobutanecarboxylic acid (anti-18F-FACBC) is a feasible alternative to 11C-methyl-L-methionine and magnetic resonance imaging for monitoring treatment response in gliomas.
Topics: Animals; Blood-Brain Barrier; Brain Neoplasms; Carboxylic Acids; Cell Line, Tumor; Cell Proliferation; Cyclobutanes; Dacarbazine; Feasibility Studies; Glioma; Magnetic Resonance Imaging; Male; Methionine; Permeability; Rats; Temozolomide; Treatment Outcome | 2013 |
Glioma initiating cells form a differentiation niche via the induction of extracellular matrices and integrin αV.
Topics: Animals; Brain Neoplasms; Carcinogenesis; Cell Adhesion; Cell Differentiation; Cell Movement; Cell Survival; Dacarbazine; Disease Progression; Extracellular Matrix; Fibronectins; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Ontology; Glioma; Humans; Integrin alphaV; Mice; Neoplasm Proteins; Neoplastic Stem Cells; Oligopeptides; Proteomics; Reproducibility of Results; RNA, Messenger; Spheroids, Cellular; Survival Analysis; Temozolomide | 2013 |
Restoration of sensitivity in chemo-resistant glioma cells by cold atmospheric plasma.
Topics: Adult; Atmosphere; Brain Neoplasms; Cell Death; Cell Division; Cell Line, Tumor; Cell Proliferation; Dacarbazine; DNA Damage; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; G2 Phase; Glioma; Humans; Plasma Gases; Temozolomide; Tumor Stem Cell Assay | 2013 |
Synergistic interactions between camptothecin and EGFR or RAC1 inhibitors and between imatinib and Notch signaling or RAC1 inhibitors in glioblastoma cell lines.
Topics: Antineoplastic Agents, Alkylating; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Benzamides; Brain Neoplasms; Camptothecin; Cell Line, Tumor; Cell Survival; Computational Biology; Dacarbazine; Drug Resistance, Neoplasm; Drug Synergism; ErbB Receptors; Glioblastoma; Humans; Imatinib Mesylate; Microarray Analysis; Piperazines; Pyrimidines; rac1 GTP-Binding Protein; Receptors, Notch; RNA, Neoplasm; Signal Transduction; Temozolomide | 2013 |
Factors predicting temozolomide induced clinically significant acute hematologic toxicity in patients with high-grade gliomas: a clinical audit.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cohort Studies; Community-Acquired Infections; Dacarbazine; Female; Glioma; Hematologic Diseases; Humans; Logistic Models; Male; Middle Aged; Neutropenia; Predictive Value of Tests; Temozolomide; Thrombocytopenia | 2013 |
Differentiation of true progression from pseudoprogression in glioblastoma treated with radiation therapy and concomitant temozolomide: comparison study of standard and high-b-value diffusion-weighted imaging.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemoradiotherapy; Dacarbazine; Diffusion Magnetic Resonance Imaging; Disease Progression; Female; Glioblastoma; Humans; Male; Middle Aged; Retrospective Studies; Temozolomide; Treatment Outcome | 2013 |
Melanoma of unknown primary origin presenting as a rapidly enlarging adrenal mass.
Topics: Adrenal Gland Neoplasms; Aged; Antineoplastic Agents; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Diagnosis, Differential; Female; Humans; Melanoma; Neoplasm Metastasis; Neoplasms, Unknown Primary; Radiosurgery; Temozolomide; Tomography, X-Ray Computed | 2013 |
Should we continue temozolomide beyond six cycles in the adjuvant treatment of glioblastoma without an evidence of clinical benefit? A cost analysis based on prescribing patterns in Spain.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemotherapy, Adjuvant; Cost-Benefit Analysis; Dacarbazine; Glioblastoma; Humans; Practice Patterns, Physicians'; Spain; Surveys and Questionnaires; Temozolomide | 2014 |
Solitary brain metastasis as first manifestation of small-cell parotid gland carcinoma with high sensitivity to temozolomide therapy on basis of tumor O6-methylguanine-DNA-methyltransferase expression.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Carcinoma, Small Cell; Dacarbazine; Female; Humans; Magnetic Resonance Imaging; Middle Aged; Neoplasm Recurrence, Local; O(6)-Methylguanine-DNA Methyltransferase; Parotid Neoplasms; Temozolomide | 2013 |
The ZEB1 pathway links glioblastoma initiation, invasion and chemoresistance.
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Cell Line, Tumor; Cell Survival; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; Drug Resistance, Neoplasm; Female; Gene Expression Regulation, Neoplastic; Glioblastoma; Homeodomain Proteins; Humans; Kruppel-Like Transcription Factors; Mice; Mice, SCID; Neoplasm Invasiveness; Neoplasm Transplantation; Nerve Tissue Proteins; Proto-Oncogene Proteins c-myb; Receptors, Immunologic; Roundabout Proteins; Temozolomide; Transcription Factors; Treatment Outcome; Tumor Suppressor Proteins; Zinc Finger E-box-Binding Homeobox 1 | 2013 |
Extracellular sphingosine-1-phosphate: a novel actor in human glioblastoma stem cell survival.
Topics: Brain Neoplasms; Cell Line, Tumor; Cell Separation; Cell Survival; Dacarbazine; Drug Resistance, Neoplasm; Extracellular Space; Glioblastoma; Humans; Intracellular Space; Lysophospholipids; Models, Biological; Neoplastic Stem Cells; Phosphotransferases (Alcohol Group Acceptor); Sphingosine; Temozolomide | 2013 |
A phase 3 trial of whole brain radiation therapy and stereotactic radiosurgery alone versus WBRT & SRS with temozolomide or erlotinib for non-small cell lung cancer and 1 to 3 brain metastases: Radiation Therapy Oncology Group 0320: in regard to Sperduto
Topics: Antineoplastic Agents; Brain Neoplasms; Carcinoma, Non-Small-Cell Lung; Cranial Irradiation; Dacarbazine; Humans; Lung Neoplasms; Quinazolines; Radiosurgery | 2013 |
In reply to Robins et al.
Topics: Antineoplastic Agents; Brain Neoplasms; Carcinoma, Non-Small-Cell Lung; Cranial Irradiation; Dacarbazine; Humans; Lung Neoplasms; Quinazolines; Radiosurgery | 2013 |
Pulsed versus conventional radiation therapy in combination with temozolomide in a murine orthotopic model of glioblastoma multiforme.
Topics: Animals; Antineoplastic Agents, Alkylating; Brain Neoplasms; Combined Modality Therapy; Cranial Irradiation; Dacarbazine; Dose Fractionation, Radiation; Glioblastoma; Mice; Mice, Nude; Multimodal Imaging; Positron-Emission Tomography; Random Allocation; Temozolomide; Tomography, X-Ray Computed; Tumor Burden | 2013 |
LRIG1 dictates the chemo-sensitivity of temozolomide (TMZ) in U251 glioblastoma cells via down-regulation of EGFR/topoisomerase-2/Bcl-2.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Line, Tumor; Cell Survival; Dacarbazine; DNA Topoisomerases, Type II; Down-Regulation; Drug Resistance, Neoplasm; ErbB Receptors; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Membrane Glycoproteins; Proto-Oncogene Proteins c-bcl-2; RNA Interference; Temozolomide | 2013 |
Early assessment of the efficacy of temozolomide chemotherapy in experimental glioblastoma using [18F]FLT-PET imaging.
Topics: Animals; Antineoplastic Agents, Alkylating; Biomarkers, Pharmacological; Brain Neoplasms; Dacarbazine; Early Diagnosis; Female; Fluorodeoxyglucose F18; Glioblastoma; Humans; Injections, Intraventricular; Injections, Subcutaneous; Mice; Mice, Nude; Neoplasms, Experimental; Temozolomide; Tomography, Emission-Computed; Treatment Outcome; Tumor Burden | 2013 |
Observational, retrospective study of the effectiveness of 5-aminolevulinic acid in malignant glioma surgery in Spain (The VISIONA study).
Topics: Aminolevulinic Acid; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Disease-Free Survival; Female; Glioma; Humans; Male; Middle Aged; Neurosurgical Procedures; Photosensitizing Agents; Retrospective Studies; Surgery, Computer-Assisted; Temozolomide; Treatment Outcome | 2014 |
Antitumor activity of (2E,5Z)-5-(2-hydroxybenzylidene)-2-((4-phenoxyphenyl)imino) thiazolidin-4-one, a novel microtubule-depolymerizing agent, in U87MG human glioblastoma cells and corresponding mouse xenograft model.
Topics: Animals; Antineoplastic Agents; Apoptosis; Brain Neoplasms; Cell Division; Cell Proliferation; Dacarbazine; Disease Models, Animal; G2 Phase Cell Cycle Checkpoints; Glioblastoma; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Microtubules; Neoplasm Transplantation; Phenyl Ethers; Temozolomide; Thiazolidines; Tubulin Modulators; Tumor Cells, Cultured | 2013 |
Polo-like kinase 1 inhibition causes decreased proliferation by cell cycle arrest, leading to cell death in glioblastoma.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Cycle Checkpoints; Cell Cycle Proteins; Cell Death; Cell Line, Tumor; Cell Proliferation; Dacarbazine; Drug Synergism; Glioblastoma; Humans; Polo-Like Kinase 1; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Temozolomide; Tumor Stem Cell Assay | 2013 |
Enhanced accumulation of curcumin and temozolomide loaded magnetic nanoparticles executes profound cytotoxic effect in glioblastoma spheroid model.
Topics: Acridine Orange; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Brain Neoplasms; Cell Culture Techniques; Cell Death; Cell Line, Tumor; Curcumin; Dacarbazine; Drug Delivery Systems; Drug Synergism; Glioblastoma; Humans; Magnetics; Nanoparticles; Propidium; Staining and Labeling; Temozolomide | 2013 |
Convection-enhanced delivery and in vivo imaging of polymeric nanoparticles for the treatment of malignant glioma.
Topics: Animals; Brain Neoplasms; Cell Line, Tumor; Convection; Dacarbazine; Drug Delivery Systems; Ferric Compounds; Glioma; Humans; Magnetic Resonance Imaging; Mice; Nanoparticles; Polymers; Radiography; Rats; Temozolomide; Xenograft Model Antitumor Assays | 2014 |
Temozolomide downregulates P-glycoprotein expression in glioblastoma stem cells by interfering with the Wnt3a/glycogen synthase-3 kinase/β-catenin pathway.
Topics: Animals; Antineoplastic Agents, Alkylating; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; beta Catenin; Brain Neoplasms; Dacarbazine; Down-Regulation; Doxorubicin; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Glioblastoma; Glycogen Synthase Kinase 3; Humans; Mice; Neoplastic Stem Cells; Temozolomide; Tumor Cells, Cultured; Wnt Signaling Pathway; Wnt3A Protein | 2013 |
Prolonged administration of adjuvant temozolomide improves survival in adult patients with glioblastoma.
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemotherapy, Adjuvant; Dacarbazine; Disease-Free Survival; Female; Glioblastoma; Humans; Male; Middle Aged; Recurrence; Temozolomide; Treatment Outcome; Young Adult | 2013 |
Cytoplasmic TRADD confers a worse prognosis in glioblastoma.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Blotting, Western; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Cytoplasm; Dacarbazine; Drug Resistance, Neoplasm; Female; Glioblastoma; Humans; Immunohistochemistry; Kaplan-Meier Estimate; Male; Middle Aged; Multivariate Analysis; Neoplastic Stem Cells; NF-kappa B; Prognosis; RNA Interference; Temozolomide; Tissue Array Analysis; TNF Receptor-Associated Death Domain Protein | 2013 |
Comparison of the clinical efficacy of temozolomide (TMZ) versus nimustine (ACNU)-based chemotherapy in newly diagnosed glioblastoma.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemoradiotherapy, Adjuvant; Combined Modality Therapy; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; Female; Glioblastoma; Humans; Kaplan-Meier Estimate; Karnofsky Performance Status; Male; Middle Aged; Nimustine; Survival Analysis; Temozolomide; Tumor Suppressor Proteins; Young Adult | 2014 |
The timing of neural stem cell-based virotherapy is critical for optimal therapeutic efficacy when applied with radiation and chemotherapy for the treatment of glioblastoma.
Topics: Adenoviridae; Animals; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Line, Transformed; Combined Modality Therapy; Dacarbazine; Gamma Rays; Genetic Vectors; Glioblastoma; Humans; Mice; Neural Stem Cells; Oncolytic Virotherapy; Oncolytic Viruses; Survival Analysis; Temozolomide; Time Factors; Xenograft Model Antitumor Assays | 2013 |
Central diabetes insipidus: a previously unreported side effect of temozolomide.
Topics: Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Dacarbazine; Diabetes Insipidus, Neurogenic; Humans; Male; Middle Aged; Pituitary Gland; Pituitary Gland, Posterior; Polydipsia; Polyuria; Temozolomide | 2013 |
Comparison of carbon ion radiotherapy to photon radiation alone or in combination with temozolomide in patients with high-grade gliomas: explorative hypothesis-generating retrospective analysis.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemoradiotherapy; Child; Child, Preschool; Dacarbazine; Glioma; Heavy Ion Radiotherapy; Humans; Infant; Neoplasm Grading; Photons; Retrospective Studies; Temozolomide | 2013 |
Chemoirradiation for glioblastoma multiforme: the national cancer institute experience.
Topics: Adult; Aged; Angiogenesis Inhibitors; Antibodies, Monoclonal, Humanized; Antineoplastic Agents, Alkylating; Bevacizumab; Brain Neoplasms; Chemoradiotherapy; Dacarbazine; Disease-Free Survival; Female; Glioblastoma; Humans; Kaplan-Meier Estimate; Male; Middle Aged; National Cancer Institute (U.S.); Neoplasm Recurrence, Local; Proportional Hazards Models; Retrospective Studies; Temozolomide; Treatment Outcome; Tumor Burden; United States | 2013 |
The Cdk inhibitor flavopiridol enhances temozolomide-induced cytotoxicity in human glioma cells.
Topics: Animals; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Cycle; Colony-Forming Units Assay; Comet Assay; Cyclin-Dependent Kinases; Dacarbazine; Drug Synergism; Female; Flavonoids; Fluorescent Antibody Technique; Glioma; Humans; Immunoblotting; Mice; Mice, Inbred BALB C; Piperidines; Protein Kinase Inhibitors; Temozolomide; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2013 |
An automated system for detecting nonadherence in laboratory testing and monitoring for myelosuppression in patients receiving self-administered oral chemotherapy.
Topics: Administration, Oral; Adult; Aged; Antineoplastic Agents, Alkylating; Blood Cell Count; Brain Neoplasms; Clinical Laboratory Services; Dacarbazine; Female; Glioblastoma; Hematologic Diseases; Humans; Male; Medication Adherence; Middle Aged; Self Administration; Software; Temozolomide | 2013 |
Establishment and characterization of primary glioblastoma cell lines from fresh and frozen material: a detailed comparison.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Benzamides; Brain Neoplasms; Carmustine; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cryopreservation; Dacarbazine; Dose-Response Relationship, Drug; ErbB Receptors; Female; Gene Dosage; Glial Fibrillary Acidic Protein; Glioblastoma; Humans; Imatinib Mesylate; Male; Middle Aged; Piperazines; Protein Kinase Inhibitors; Pyrimidines; Temozolomide; Tumor Cells, Cultured; Vincristine | 2013 |
Stupp-treated glioblastoma accompanied by EBV-positive primary CNS lymphoma.
Topics: Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemoradiotherapy; Clinical Protocols; Dacarbazine; Epstein-Barr Virus Infections; Fatal Outcome; Glioblastoma; Headache; Humans; Lymphoma, B-Cell; Magnetic Resonance Imaging; Male; Neurosurgical Procedures; Temozolomide; Tomography, X-Ray Computed | 2014 |
Toca 511 gene transfer and 5-fluorocytosine in combination with temozolomide demonstrates synergistic therapeutic efficacy in a temozolomide-sensitive glioblastoma model.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cytosine Deaminase; Dacarbazine; Drug Synergism; Female; Flucytosine; Gene Expression; Gene Transfer Techniques; Genetic Vectors; Glioblastoma; Mice; Mice, Nude; Retroviridae; Temozolomide; Xenograft Model Antitumor Assays | 2013 |
Meningeal seeding from glioblastoma multiforme treated with radiotherapy and temozolomide.
Topics: Adult; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemoradiotherapy, Adjuvant; Dacarbazine; Fatal Outcome; Glioblastoma; Humans; Male; Meningeal Neoplasms; Neoplasm Seeding; Temozolomide | 2017 |
Glioblastoma management in the temozolomide era: have we improved outcome?
Topics: Adolescent; Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemoradiotherapy; Dacarbazine; Disease Management; Female; Follow-Up Studies; Glioblastoma; Humans; Male; Middle Aged; Neoplasm Staging; Prognosis; Retrospective Studies; Survival Rate; Temozolomide; Young Adult | 2013 |
Concomitant and adjuvant temozolomide of newly diagnosed glioblastoma in elderly patients.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemoradiotherapy; Chemotherapy, Adjuvant; Cohort Studies; Combined Modality Therapy; Dacarbazine; Female; Glioblastoma; Humans; Kaplan-Meier Estimate; Karnofsky Performance Status; Male; Middle Aged; Multivariate Analysis; Neurosurgical Procedures; Retrospective Studies; Survival Analysis; Temozolomide; Young Adult | 2013 |
Triacetin-based acetate supplementation as a chemotherapeutic adjuvant therapy in glioma.
Topics: Amidohydrolases; Animals; Antifungal Agents; Aspartic Acid; Astrocytes; Brain; Brain Neoplasms; Cell Cycle; Cells, Cultured; Dacarbazine; Dietary Supplements; Flow Cytometry; Gene Expression Regulation, Neoplastic; Glioma; Humans; Mice; Neoplasm Grading; Neoplasm Recurrence, Local; Neoplastic Stem Cells; Neural Stem Cells; Temozolomide; Triacetin | 2014 |
Clinical variables serve as prognostic factors in a model for survival from glioblastoma multiforme: an observational study of a cohort of consecutive non-selected patients from a single institution.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Female; Glioblastoma; Humans; Immunohistochemistry; Male; Middle Aged; Neoplasm Staging; Prognosis; Recurrence; Reoperation; Risk Factors; Temozolomide; Treatment Outcome; Young Adult | 2013 |
Glioblastoma occurring after the surgical resection of a craniopharyngioma.
Topics: Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemoradiotherapy; Clinical Protocols; Craniopharyngioma; Dacarbazine; Glioblastoma; Humans; Immunohistochemistry; Magnetic Resonance Imaging; Male; Neurosurgical Procedures; Pituitary Neoplasms; Temozolomide; Tomography, X-Ray Computed | 2014 |
YB-1 dependent oncolytic adenovirus efficiently inhibits tumor growth of glioma cancer stem like cells.
Topics: Adenoviridae; Animals; Astrocytes; Brain Neoplasms; Cell Hypoxia; Cell Line, Tumor; Cell Proliferation; Dacarbazine; Disease Models, Animal; DNA Modification Methylases; DNA Repair Enzymes; Down-Regulation; Drug Resistance, Neoplasm; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Glioma; Humans; Mice; Neoplastic Stem Cells; Oncolytic Viruses; Phosphorylation; Proto-Oncogene Proteins c-akt; RNA, Small Interfering; Temozolomide; Tumor Suppressor Proteins; Virus Replication; Xenograft Model Antitumor Assays; Y-Box-Binding Protein 1 | 2013 |
miR-125b inhibits Connexin43 and promotes glioma growth.
Topics: 3' Untranslated Regions; Animals; Apoptosis; Base Sequence; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Clone Cells; Connexin 43; Dacarbazine; Down-Regulation; Gene Expression Regulation, Neoplastic; Glioma; HEK293 Cells; Humans; Mice; Mice, Nude; MicroRNAs; Molecular Sequence Data; Protein Binding; Rats; RNA, Messenger; Temozolomide | 2013 |
Time trends in glioblastoma multiforme survival: the role of temozolomide.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cohort Studies; Combined Modality Therapy; Dacarbazine; Female; Follow-Up Studies; Glioblastoma; Humans; Male; Middle Aged; Neoplasm Staging; Prognosis; Radiotherapy Dosage; Survival Rate; Temozolomide; Time Factors | 2013 |
Mitochondrial protein ATPase family, AAA domain containing 3A correlates with radioresistance in glioblastoma.
Topics: Adenosine Triphosphatases; Antineoplastic Agents, Alkylating; ATPases Associated with Diverse Cellular Activities; Blotting, Western; Brain Neoplasms; Cell Differentiation; Cell Proliferation; Chemoradiotherapy; Dacarbazine; DNA Methylation; Female; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Immunoenzyme Techniques; Male; Membrane Proteins; Middle Aged; Mitochondria; Mitochondrial Proteins; Neoplasm Staging; O(6)-Methylguanine-DNA Methyltransferase; Prognosis; Radiation Tolerance; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Small Interfering; Survival Rate; Temozolomide; Tumor Cells, Cultured | 2013 |
Long-term treatment with temozolomide in malignant glioma.
Topics: Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Female; Glioma; Humans; Maintenance Chemotherapy; Male; Middle Aged; Temozolomide | 2014 |
The temozolomide derivative 2T-P400 inhibits glioma growth via administration route of intravenous injection.
Topics: Animals; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Dacarbazine; Disease Models, Animal; Dose-Response Relationship, Drug; Glioma; Humans; Injections, Intravenous; Mice; Mice, Inbred BALB C; Mice, Nude; Subcutaneous Tissue; Temozolomide; Time Factors; Treatment Outcome; Xenograft Model Antitumor Assays | 2014 |
Temozolomide and irradiation combined treatment-induced Nrf2 activation increases chemoradiation sensitivity in human glioblastoma cells.
Topics: Adult; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; Down-Regulation; Female; Glioblastoma; Heme Oxygenase-1; Humans; Male; Middle Aged; NAD(P)H Dehydrogenase (Quinone); NF-E2-Related Factor 2; Radiation; RNA, Messenger; Temozolomide | 2014 |
A case of adult onset medulloblastoma during maintenance chemotherapy for anaplastic astrocytoma one year after radiotherapy.
Topics: Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Cerebellar Neoplasms; Chemoradiotherapy; Combined Modality Therapy; Dacarbazine; Epilepsy, Complex Partial; Humans; Immunohistochemistry; Magnetic Resonance Imaging; Maintenance Chemotherapy; Male; Medulloblastoma; Temozolomide; Tomography, X-Ray Computed | 2013 |
A survival analysis of GBM patients in the West of Scotland pre- and post-introduction of the Stupp regime.
Topics: Adolescent; Adult; Age Factors; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemoradiotherapy; Combined Modality Therapy; Dacarbazine; Female; Glioblastoma; Humans; Kaplan-Meier Estimate; Karnofsky Performance Status; Male; Middle Aged; Neurosurgical Procedures; Scotland; Survival Analysis; Temozolomide; Young Adult | 2014 |
Biliverdin reductase plays a crucial role in hypoxia-induced chemoresistance in human glioblastoma.
Topics: Antineoplastic Agents, Alkylating; Antineoplastic Agents, Phytogenic; Apoptosis; Brain Neoplasms; Cell Hypoxia; Cell Line, Tumor; Dacarbazine; Drug Resistance, Neoplasm; Glioblastoma; Humans; Oxidation-Reduction; Oxidoreductases Acting on CH-CH Group Donors; Paclitaxel; Reactive Oxygen Species; Temozolomide | 2013 |
Clinical course of central neurocytoma with malignant transformation-an indication for craniospinal irradiation.
Topics: Adult; Brain Neoplasms; Cell Transformation, Neoplastic; Cerebrospinal Fluid; Chemotherapy, Adjuvant; Child, Preschool; Craniospinal Irradiation; Dacarbazine; Female; Humans; Ki-67 Antigen; Magnetic Resonance Imaging; Male; Middle Aged; Neurocytoma; Radiotherapy, Adjuvant; Temozolomide; Young Adult | 2014 |
High expression of leptin receptor leads to temozolomide resistance with exhibiting stem/progenitor cell features in gliobalastoma.
Topics: AC133 Antigen; Antigens, CD; Antineoplastic Agents, Alkylating; Apoptosis; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; Drug Resistance, Neoplasm; Glioblastoma; Glycoproteins; Humans; Neoplastic Stem Cells; Octamer Transcription Factor-3; Peptides; Receptors, Leptin; Signal Transduction; SOXB1 Transcription Factors; STAT3 Transcription Factor; Temozolomide | 2013 |
Factors associated with a higher rate of distant failure after primary treatment for glioblastoma.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Disease Progression; DNA Modification Methylases; DNA Repair Enzymes; Female; Glioblastoma; Humans; Karnofsky Performance Status; Magnetic Resonance Imaging; Male; Middle Aged; Multivariate Analysis; Neoplasm Recurrence, Local; Promoter Regions, Genetic; Radiotherapy; Temozolomide; Tumor Suppressor Proteins | 2014 |
Retrospective analysis of bevacizumab in combination with ifosfamide, carboplatin, and etoposide in patients with second recurrence of glioblastoma.
Topics: Adult; Aged; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Brain Neoplasms; Carboplatin; Combined Modality Therapy; Dacarbazine; Disease-Free Survival; Drug Administration Schedule; Etoposide; Female; Glioblastoma; Hematologic Diseases; Humans; Ifosfamide; Interferons; Kaplan-Meier Estimate; Male; Middle Aged; Neoplasm Recurrence, Local; Retrospective Studies; Salvage Therapy; Temozolomide; Treatment Outcome | 2013 |
Treatment results of glioblastoma during the last 30 years in a single institute.
Topics: Age Factors; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemotherapy, Adjuvant; Combined Modality Therapy; Cranial Irradiation; Craniotomy; Dacarbazine; Disease-Free Survival; Female; Glioblastoma; Hospitals, University; Humans; Japan; Kaplan-Meier Estimate; Magnetic Resonance Imaging; Male; Middle Aged; Neuronavigation; Nimustine; Prognosis; Retrospective Studies; Temozolomide; Treatment Outcome | 2013 |
Effectiveness of adjuvant temozolomide treatment in patients with glioblastoma.
Topics: Aged; Antineoplastic Agents; Brain Neoplasms; Canada; Chemotherapy, Adjuvant; Dacarbazine; Female; Glioblastoma; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Neurosurgical Procedures; Radiotherapy; Retrospective Studies; Temozolomide; Treatment Outcome | 2013 |
Inhibition of MMP14 potentiates the therapeutic effect of temozolomide and radiation in gliomas.
Topics: Animals; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Division; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dacarbazine; Disease Models, Animal; Female; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Gene Silencing; Glioma; Humans; Matrix Metalloproteinase 14; Mice; MicroRNAs; Radiation; RNA Interference; Temozolomide; Xenograft Model Antitumor Assays | 2013 |
Health-related quality of life and cognitive functioning in long-term anaplastic oligodendroglioma and oligoastrocytoma survivors.
Topics: Aged; Astrocytoma; Brain Neoplasms; Cognition Disorders; Cohort Studies; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; Female; Health Status; Humans; Male; Middle Aged; Neuropsychological Tests; Quality of Life; Radiotherapy; Statistics, Nonparametric; Survivors; Temozolomide; Tumor Suppressor Proteins | 2014 |
Combination of anti-VEGF therapy and temozolomide in two experimental human glioma models.
Topics: Animals; Antibodies; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; Disease Models, Animal; Follow-Up Studies; Glioma; Humans; Laminin; Male; Rats; Rats, Nude; Survival Analysis; Temozolomide; Vascular Endothelial Growth Factor A; Xenograft Model Antitumor Assays | 2014 |
Temporal relationship of post-operative radiotherapy with temozolomide and oncologic outcome for glioblastoma.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cohort Studies; Dacarbazine; Female; Glioblastoma; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Radiosurgery; Regression Analysis; Statistics, Nonparametric; Temozolomide; Treatment Outcome | 2014 |
Cisplatin and temozolomide combination in the treatment of supratentorial anaplastic ependymoma.
Topics: Antineoplastic Agents; Brain Neoplasms; Cisplatin; Dacarbazine; Drug Therapy, Combination; Ependymoma; Female; Humans; Magnetic Resonance Imaging; Middle Aged; Radiography; Temozolomide; Treatment Outcome | 2013 |
Employment following chemoradiotherapy in glioblastoma: a prospective case series.
Topics: Adolescent; Adult; Aged; Brain Damage, Chronic; Brain Neoplasms; Chemoradiotherapy; Combined Modality Therapy; Dacarbazine; Employment; Female; Glioblastoma; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Prospective Studies; Radiotherapy, Intensity-Modulated; Severity of Illness Index; Survivors; Temozolomide; Young Adult | 2014 |
Treatment of newly diagnosed malignant glioma in the elderly people: new trials that impact therapy.
Topics: Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Carmustine; Chemoradiotherapy; Dacarbazine; Glioblastoma; Guanosine; Humans; Methylation; Middle Aged; Radiotherapy Dosage; Randomized Controlled Trials as Topic; Survival Rate; Temozolomide | 2013 |
Toxicity and outcome of radiotherapy with concomitant and adjuvant temozolomide in elderly patients with glioblastoma: a retrospective study.
Topics: Age Factors; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemoradiotherapy; Chemoradiotherapy, Adjuvant; Cognition Disorders; Dacarbazine; Disease-Free Survival; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Female; Glioblastoma; Hematologic Diseases; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Prognosis; Promoter Regions, Genetic; Retrospective Studies; Temozolomide; Treatment Outcome; Tumor Suppressor Proteins | 2014 |
Central neurotoxicity of standard treatment in patients with newly-diagnosed high-grade glioma: a prospective longitudinal study.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents, Alkylating; Atrophy; Brain Neoplasms; Cerebral Cortex; Cognition Disorders; Dacarbazine; Female; Glioma; Humans; Kaplan-Meier Estimate; Leukoencephalopathies; Longitudinal Studies; Magnetic Resonance Imaging; Male; Middle Aged; Neuropsychological Tests; Temozolomide; Young Adult | 2014 |
Is there pseudoprogression in secondary glioblastomas?
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemoradiotherapy, Adjuvant; Chromosomes, Human, 1-3; Dacarbazine; Disease Progression; Disease-Free Survival; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Female; Gene Deletion; Glioblastoma; Humans; Isocitrate Dehydrogenase; Magnetic Resonance Imaging; Male; Middle Aged; Mutation; Retrospective Studies; Temozolomide; Tumor Suppressor Proteins | 2013 |
Evaluation of post-operative complications associated with repeat resection and BCNU wafer implantation in recurrent glioblastoma.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Carmustine; Combined Modality Therapy; Dacarbazine; Disease-Free Survival; Glioblastoma; Humans; Middle Aged; Neoplasm Recurrence, Local; Postoperative Complications; Prognosis; Retrospective Studies; Temozolomide | 2014 |
Temozolomide-related acute lymphoblastic leukemia with translocation (4;11)(q21;q23) in a glioblastoma patient.
Topics: Antineoplastic Agents, Alkylating; Bone Marrow; Brain Neoplasms; Cytogenetic Analysis; Dacarbazine; Fatal Outcome; Female; Glioblastoma; Humans; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Temozolomide; Translocation, Genetic | 2014 |
Inhibition of elongation factor-2 kinase augments the antitumor activity of Temozolomide against glioma.
Topics: Animals; Antineoplastic Agents, Alkylating; Apoptosis; Brain Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Dacarbazine; Disease Models, Animal; Drug Resistance, Neoplasm; Drug Synergism; Elongation Factor 2 Kinase; Glioma; Humans; Male; Mice; Protein Kinase Inhibitors; RNA Interference; Temozolomide; Xenograft Model Antitumor Assays | 2013 |
Increased sensitivity to radiochemotherapy in IDH1 mutant glioblastoma as demonstrated by serial quantitative MR volumetry.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemoradiotherapy; Dacarbazine; Glioblastoma; Humans; Isocitrate Dehydrogenase; Kaplan-Meier Estimate; Magnetic Resonance Imaging; Middle Aged; Mutation; Temozolomide; Treatment Outcome | 2014 |
Response of primary glioblastoma cells to therapy is patient specific and independent of cancer stem cell phenotype.
Topics: AC133 Antigen; Antigens, CD; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Survival; Chemoradiotherapy; Dacarbazine; Glioblastoma; Glycoproteins; Humans; Neoplastic Stem Cells; Peptides; Phenotype; Temozolomide; Tumor Cells, Cultured | 2014 |
Lobarstin enhances chemosensitivity in human glioblastoma T98G cells.
Topics: Antineoplastic Agents; Base Sequence; Benzofurans; Brain Neoplasms; Cell Line, Tumor; Comet Assay; Dacarbazine; DNA Damage; DNA Primers; DNA Repair; Drug Synergism; Glioblastoma; Humans; Hydroxybenzoates; O(6)-Methylguanine-DNA Methyltransferase; Reverse Transcriptase Polymerase Chain Reaction; Temozolomide | 2013 |
Mechanism of temozolomide-induced antitumour effects on glioma cells.
Topics: Antineoplastic Agents; Apoptosis; Brain Neoplasms; Cell Cycle; Dacarbazine; Flow Cytometry; Glioma; Humans; Inhibitory Concentration 50; Microscopy, Fluorescence; Temozolomide | 2014 |
Mutational analysis reveals the origin and therapy-driven evolution of recurrent glioma.
Topics: Antineoplastic Agents, Alkylating; Brain; Brain Neoplasms; Dacarbazine; DNA Helicases; DNA Mutational Analysis; Glioma; Humans; Mutagenesis; Neoplasm Grading; Neoplasm Recurrence, Local; Nuclear Proteins; Proto-Oncogene Proteins B-raf; Proto-Oncogene Proteins c-akt; Temozolomide; TOR Serine-Threonine Kinases; Transcription Factors; Tumor Suppressor Protein p53; X-linked Nuclear Protein | 2014 |
Concomitant treatment with pertussis toxin plus temozolomide increases the survival of rats bearing intracerebral RG2 glioma.
Topics: Animals; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Autophagy; Blotting, Western; Brain Neoplasms; Cell Cycle; Cell Proliferation; Dacarbazine; Disease Models, Animal; Glioma; Male; Pertussis Toxin; Rats; Rats, Wistar; Survival Rate; Temozolomide | 2014 |
[Results of postoperative radiochemotherapy of glioblastoma multiforme].
Topics: Adult; Aged; Antineoplastic Agents; Brain Neoplasms; Chemoradiotherapy, Adjuvant; Dacarbazine; Disease-Free Survival; Drug Administration Schedule; Female; Follow-Up Studies; Glioblastoma; Humans; Hungary; Male; Middle Aged; Neurosurgical Procedures; Radiotherapy Dosage; Radiotherapy, Conformal; Retrospective Studies; Sex Factors; Survival Analysis; Temozolomide; Treatment Outcome | 2013 |
[Our experience with targeted therapy in glioblastoma multiforme].
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Angiogenesis Inhibitors; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Brain Neoplasms; Chemotherapy, Adjuvant; Dacarbazine; Female; Glioblastoma; Humans; Male; Middle Aged; Molecular Targeted Therapy; Neurosurgical Procedures; Radiotherapy, Adjuvant; Temozolomide; Treatment Outcome; Vascular Endothelial Growth Factor A | 2013 |
Local delivery of angiogenesis-inhibitor minocycline combined with radiotherapy and oral temozolomide chemotherapy in 9L glioma.
Topics: Administration, Oral; Angiogenesis Inhibitors; Animals; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemoradiotherapy; Combined Modality Therapy; Dacarbazine; Disease Models, Animal; Drug Delivery Systems; Female; Gliosarcoma; Minocycline; Neoplasm Transplantation; Polymers; Rats; Rats, Inbred F344; Temozolomide | 2014 |
EGFR wild type antagonizes EGFRvIII-mediated activation of Met in glioblastoma.
Topics: Brain Neoplasms; Cell Line, Tumor; Dacarbazine; Epidermal Growth Factor; ErbB Receptors; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Phenotype; Phosphorylation; Proto-Oncogene Proteins c-met; Receptor Protein-Tyrosine Kinases; Temozolomide | 2015 |
Extraneural metastases of anaplastic oligodendroglioma.
Topics: Antineoplastic Agents, Alkylating; Bone Neoplasms; Brain Neoplasms; Dacarbazine; Humans; Lymphatic Metastasis; Male; Middle Aged; Neoplasm Recurrence, Local; Oligodendroglioma; Temozolomide | 2014 |
Vemurafenib in pediatric patients with BRAFV600E mutated high-grade gliomas.
Topics: Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Bevacizumab; Brain Neoplasms; Camptothecin; Cancer Vaccines; Child; Combined Modality Therapy; Cranial Irradiation; Dacarbazine; Doxorubicin; Drug Evaluation; Fatal Outcome; Ganglioglioma; Humans; Immunotherapy; Indoles; Infant; Irinotecan; Male; Mutation, Missense; Neoplasm Proteins; Point Mutation; Polyethylene Glycols; Protein Kinase Inhibitors; Proto-Oncogene Proteins B-raf; Salvage Therapy; Sulfonamides; Temozolomide; Thalamus; Treatment Outcome; Vemurafenib | 2014 |
Concomitant viral and bacterial encephalitis after temozolomide for glioblastoma.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Encephalitis, Viral; Glioblastoma; Humans; Infectious Encephalitis; Male; Middle Aged; Temozolomide | 2014 |
A fatal case of acute interstitial pneumonia (AIP) in a woman affected by glioblastoma.
Topics: Aged; Antineoplastic Agents, Alkylating; Blood Gas Analysis; Brain Neoplasms; Bronchoalveolar Lavage Fluid; Dacarbazine; Electrocardiography; Fatal Outcome; Female; Glioblastoma; Humans; Lung; Lung Diseases, Interstitial; Physical Examination; Pneumocystis carinii; Pneumonia, Pneumocystis; Temozolomide; Trimethoprim, Sulfamethoxazole Drug Combination | 2014 |
Improved hippocampal dose with reduced margin radiotherapy for glioblastoma multiforme.
Topics: Brain Neoplasms; Chemoradiotherapy; Chemotherapy, Adjuvant; Clinical Trials, Phase III as Topic; Dacarbazine; Glioblastoma; Hippocampus; Humans; Magnetic Resonance Imaging; Organs at Risk; Radiometry; Radiotherapy Dosage; Radiotherapy Planning, Computer-Assisted; Radiotherapy, Image-Guided; Temozolomide; Tomography, X-Ray Computed; Tumor Burden | 2014 |
Enhanced cytotoxic effect of radiation and temozolomide in malignant glioma cells: targeting PI3K-AKT-mTOR signaling, HSP90 and histone deacetylases.
Topics: Antineoplastic Agents, Alkylating; Apoptosis; Autophagy; Brain Neoplasms; Cell Line, Tumor; Cell Movement; Chemoradiotherapy; Dacarbazine; DNA Damage; DNA Modification Methylases; DNA Repair Enzymes; Dose-Response Relationship, Radiation; Epigenesis, Genetic; Epithelial-Mesenchymal Transition; ErbB Receptors; Glioma; Histone Deacetylase Inhibitors; Histone Deacetylases; HSP90 Heat-Shock Proteins; Humans; Neoplasm Grading; Phosphatidylinositol 3-Kinase; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Radiation-Sensitizing Agents; RNA Interference; Signal Transduction; Temozolomide; TOR Serine-Threonine Kinases; Transfection; Tumor Suppressor Proteins | 2014 |
Outcome-based determination of optimal pyrosequencing assay for MGMT methylation detection in glioblastoma patients.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Cohort Studies; Dacarbazine; Disease Notification; Disease-Free Survival; DNA Methylation; DNA-Cytosine Methylases; Female; Glioblastoma; Humans; Male; O(6)-Methylguanine-DNA Methyltransferase; ROC Curve; Sequence Analysis, DNA; Survival Analysis; Temozolomide; Treatment Outcome | 2014 |
Synergistic inhibition of angiogenesis and glioma cell-induced angiogenesis by the combination of temozolomide and enediyne antibiotic lidamycin.
Topics: Aminoglycosides; Angiogenesis Inhibitors; Animals; Anti-Bacterial Agents; Apoptosis; Brain; Brain Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Dacarbazine; Drug Synergism; Endothelial Cells; Enediynes; Glioma; Heterografts; Humans; Male; Mice, Nude; Neovascularization, Pathologic; Rats; Temozolomide; Vascular Endothelial Growth Factor A | 2014 |
Potential application of temozolomide in mesenchymal stem cell-based TRAIL gene therapy against malignant glioma.
Topics: Adult; Animals; Antineoplastic Agents, Alkylating; Apoptosis; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; Genetic Therapy; Glioma; Humans; Male; MAP Kinase Signaling System; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Mice; Mice, Nude; Middle Aged; Temozolomide; TNF-Related Apoptosis-Inducing Ligand; Xenograft Model Antitumor Assays; Young Adult | 2014 |
Hyperdiploid tumor cells increase phenotypic heterogeneity within Glioblastoma tumors.
Topics: Animals; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Division; Cell Proliferation; Dacarbazine; Diploidy; Drug Resistance, Neoplasm; Female; G1 Phase Cell Cycle Checkpoints; Glioblastoma; Glycolysis; Humans; Mice; Mice, Inbred NOD; Mice, SCID; Neoplasm Recurrence, Local; Neoplasm Transplantation; Spheroids, Cellular; Temozolomide; Transplantation, Heterologous; Tumor Cells, Cultured | 2014 |
Large volume reirradiation as salvage therapy for glioblastoma after progression on bevacizumab.
Topics: Adult; Aged; Angiogenesis Inhibitors; Antibodies, Monoclonal, Humanized; Antineoplastic Agents, Alkylating; Bevacizumab; Brain Neoplasms; Dacarbazine; Disease-Free Survival; Female; Glioblastoma; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Neoplasm Recurrence, Local; Radiotherapy, Conformal; Retreatment; Retrospective Studies; Salvage Therapy; Temozolomide; Treatment Failure; Treatment Outcome | 2014 |
Factors impacting survival following second surgery in patients with glioblastoma in the temozolomide treatment era, incorporating neutrophil/lymphocyte ratio and time to first progression.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Female; Follow-Up Studies; Glioblastoma; Humans; Lymphocytes; Male; Middle Aged; Neoplasm Recurrence, Local; Neutrophils; Prognosis; Reoperation; Retrospective Studies; Survival Analysis; Temozolomide; Time Factors; Young Adult | 2014 |
Conditional probability of survival and post-progression survival in patients with glioblastoma in the temozolomide treatment era.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Chemoradiotherapy; Dacarbazine; Female; Follow-Up Studies; Glioblastoma; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Probability; Prognosis; Retrospective Studies; Temozolomide; Time Factors; Young Adult | 2014 |
The adherens junction-associated protein 1 is a negative transcriptional regulator of MAGEA2, which potentiates temozolomide-induced apoptosis in GBM.
Topics: Adherens Junctions; Antineoplastic Agents, Alkylating; Apoptosis; bcl-2-Associated X Protein; Brain Neoplasms; Caspase 3; Caspase 7; Cell Adhesion Molecules; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Movement; Dacarbazine; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Glioblastoma; HEK293 Cells; Histone Deacetylases; Humans; In Situ Nick-End Labeling; Melanoma-Specific Antigens; Neoplasm Proteins; Temozolomide; Transcription, Genetic; Tumor Suppressor Protein p53 | 2014 |
EFEMP1 induces γ-secretase/Notch-mediated temozolomide resistance in glioblastoma.
Topics: Amyloid Precursor Protein Secretases; Animals; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Benzazepines; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; Drug Resistance, Neoplasm; Extracellular Matrix Proteins; Female; Gene Expression; Glioblastoma; Humans; Mice; Receptors, Notch; Signal Transduction; Temozolomide; Transfection | 2014 |
Initial and cumulative recurrence patterns of glioblastoma after temozolomide-based chemoradiotherapy and salvage treatment: a retrospective cohort study in a single institution.
Topics: Adult; Aged; Antineoplastic Agents; Brain Neoplasms; Chemoradiotherapy; Cohort Studies; Dacarbazine; Female; Glioblastoma; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Neoplasm Recurrence, Local; Retrospective Studies; Salvage Therapy; Temozolomide | 2013 |
Temozolomide does not impair gene therapy-mediated antitumor immunity in syngeneic brain tumor models.
Topics: Adenoviridae; Animals; Antineoplastic Agents; Brain Neoplasms; Dacarbazine; Disease Models, Animal; Genetic Therapy; Genetic Vectors; Glioblastoma; Immunotherapy; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Temozolomide; Thymidine Kinase | 2014 |
Asparagine depletion potentiates the cytotoxic effect of chemotherapy against brain tumors.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Asparagine; Aspartate-Ammonia Ligase; Brain Neoplasms; Cell Growth Processes; Cell Line, Tumor; Dacarbazine; DNA Damage; Drug Synergism; Glioblastoma; Glutamine; Humans; Male; Medulloblastoma; Mice; Mice, Nude; Temozolomide; Xenograft Model Antitumor Assays | 2014 |
[Management of patients with metastatic cutaneous melanoma: French national guidelines. French National Cancer Institute].
Topics: Antibodies, Monoclonal; Antineoplastic Agents; Bone Neoplasms; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Disease Management; France; Humans; Indoles; Ipilimumab; Liver Neoplasms; Lung Neoplasms; Melanoma; Molecular Targeted Therapy; Neoplasm Staging; Nitrosourea Compounds; Oncogenes; Organophosphorus Compounds; Proto-Oncogene Proteins B-raf; Skin Neoplasms; Sulfonamides; Temozolomide; Vemurafenib | 2014 |
MGMT promoter methylation in plasma of glioma patients receiving temozolomide.
Topics: Aged; Antineoplastic Agents, Alkylating; Biomarkers, Tumor; Brain Neoplasms; Dacarbazine; Disease-Free Survival; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Female; Glioma; Humans; Male; Middle Aged; Promoter Regions, Genetic; Proportional Hazards Models; Real-Time Polymerase Chain Reaction; Temozolomide; Tumor Suppressor Proteins | 2014 |
Bevacizumab in glioblastoma--still much to learn.
Topics: Angiogenesis Inhibitors; Antibodies, Monoclonal, Humanized; Bevacizumab; Brain Neoplasms; Dacarbazine; Female; Glioblastoma; Humans; Male; Temozolomide | 2014 |
Outcome of conventional treatment and prognostic factor in elderly glioblastoma patients.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemoradiotherapy; Chemotherapy, Adjuvant; Combined Modality Therapy; Dacarbazine; Disease-Free Survival; Female; Follow-Up Studies; Glioblastoma; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Multivariate Analysis; Neurosurgical Procedures; Prognosis; Retrospective Studies; Temozolomide; Treatment Outcome | 2014 |
The NFκB inhibitor, SN50, induces differentiation of glioma stem cells and suppresses their oncogenic phenotype.
Topics: Animals; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Differentiation; Dacarbazine; Drug Resistance, Neoplasm; Gene Expression Regulation; Glioblastoma; Heterografts; Humans; Mice, Nude; Neoplasm Invasiveness; Neoplastic Stem Cells; NF-kappa B; Peptides; Temozolomide; Tumor Cells, Cultured | 2014 |
miR-181 subunits enhance the chemosensitivity of temozolomide by Rap1B-mediated cytoskeleton remodeling in glioblastoma cells.
Topics: Actins; Antineoplastic Agents, Alkylating; Base Sequence; Brain Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cytoskeleton; Dacarbazine; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; MicroRNAs; Molecular Sequence Data; rap GTP-Binding Proteins; Temozolomide; Up-Regulation | 2014 |
Patterns of care and survival of glioblastoma patients: a comparative study between 2004 and 2008 in Lyon, France.
Topics: Aged; Angiogenesis Inhibitors; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Bevacizumab; Brain Neoplasms; Chemoradiotherapy; Chemotherapy, Adjuvant; Combined Modality Therapy; Cranial Irradiation; Dacarbazine; Disease Management; Female; France; Glioblastoma; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Neoplasm Recurrence, Local; Nitrosourea Compounds; Palliative Care; Temozolomide; Treatment Outcome | 2014 |
BRAF-V600 mutations have no prognostic impact in stage IV melanoma patients treated with monochemotherapy.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Female; Follow-Up Studies; Humans; Male; Melanoma; Middle Aged; Mutation; Neoplasm Staging; Prognosis; Proto-Oncogene Proteins B-raf; Skin Neoplasms; Survival Rate; Temozolomide | 2014 |
Quantitative metabolome analysis profiles activation of glutaminolysis in glioma with IDH1 mutation.
Topics: Brain Neoplasms; Cell Line, Tumor; Dacarbazine; Glioma; Glutaminase; Glutamine; Glutarates; HEK293 Cells; Humans; Isocitrate Dehydrogenase; Ketoglutaric Acids; Metabolome; Mutation; Temozolomide | 2014 |
Analysis of salivary fluid and chemosensory functions in patients treated for primary malignant brain tumors.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Case-Control Studies; Combined Modality Therapy; Dacarbazine; Female; Glioma; Humans; Male; Middle Aged; Olfaction Disorders; Oxidative Stress; Radiotherapy; Saliva; Salivary Proteins and Peptides; Taste Disorders; Temozolomide | 2015 |
Conversion of differentiated cancer cells into cancer stem-like cells in a glioblastoma model after primary chemotherapy.
Topics: Animals; Antineoplastic Agents, Alkylating; Basic Helix-Loop-Helix Transcription Factors; Brain Neoplasms; Cell Line, Tumor; Cell Transformation, Neoplastic; Dacarbazine; Glioblastoma; Humans; Male; Mice, Nude; Neoplastic Stem Cells; Phenotype; Temozolomide; Xenograft Model Antitumor Assays | 2014 |
Odds of death after glioblastoma diagnosis in the United States by chemotherapeutic era.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal, Humanized; Bevacizumab; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Female; Glioblastoma; Humans; Male; Middle Aged; Proportional Hazards Models; Temozolomide; Treatment Outcome; United States | 2014 |
In vivo chemical exchange saturation transfer imaging allows early detection of a therapeutic response in glioblastoma.
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Dacarbazine; Glioblastoma; Humans; Mice; Mice, SCID; Prognosis; Temozolomide; Treatment Outcome; Xenograft Model Antitumor Assays | 2014 |
A novel temozolomide-perillyl alcohol conjugate exhibits superior activity against breast cancer cells in vitro and intracranial triple-negative tumor growth in vivo.
Topics: Animals; Brain Neoplasms; Cell Line, Tumor; Cell Survival; Dacarbazine; Disease Models, Animal; DNA Modification Methylases; DNA Repair Enzymes; Drug Combinations; Drug Resistance, Neoplasm; Humans; Mice; Monoterpenes; Temozolomide; Triple Negative Breast Neoplasms; Tumor Suppressor Proteins; Xenograft Model Antitumor Assays | 2014 |
A BRCA1 deficient-like signature is enriched in breast cancer brain metastases and predicts DNA damage-induced poly (ADP-ribose) polymerase inhibitor sensitivity.
Topics: Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Brain Neoplasms; BRCA1 Protein; Breast Neoplasms; Cell Line; Cell Line, Tumor; Dacarbazine; DNA Damage; DNA Mutational Analysis; Enzyme Inhibitors; Female; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; Oligonucleotide Array Sequence Analysis; Phthalazines; Piperazines; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Prognosis; Receptor, ErbB-2; Temozolomide; Transcriptome | 2014 |
Profound prevention of experimental brain metastases of breast cancer by temozolomide in an MGMT-dependent manner.
Topics: Animals; Antineoplastic Agents, Alkylating; Brain Neoplasms; Breast Neoplasms; Cell Line, Tumor; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Immunohistochemistry; Kaplan-Meier Estimate; MCF-7 Cells; Mice; Mice, Nude; RNA Interference; Temozolomide; Treatment Outcome; Triple Negative Breast Neoplasms; Tumor Suppressor Proteins; Xenograft Model Antitumor Assays | 2014 |
Neuro-oncology: Bevacizumab prolongs progression-free survival but not overall survival in newly diagnosed glioblastoma.
Topics: Angiogenesis Inhibitors; Antibodies, Monoclonal, Humanized; Brain Neoplasms; Dacarbazine; Female; Glioblastoma; Humans; Male | 2014 |
Impact of systemic treatment on survival after whole brain radiotherapy in patients with brain metastases.
Topics: Aged; Antineoplastic Agents; Brain; Brain Neoplasms; Dacarbazine; Female; Humans; Male; Middle Aged; Multivariate Analysis; Neoplasm Metastasis; Neoplasms; Prognosis; Proportional Hazards Models; Retrospective Studies; Temozolomide; Treatment Outcome | 2014 |
Relationship between survival and increased radiation dose to subventricular zone in glioblastoma is controversial.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemoradiotherapy; Dacarbazine; Disease-Free Survival; Female; Follow-Up Studies; Glioblastoma; Humans; Lateral Ventricles; Male; Middle Aged; Proportional Hazards Models; Radiotherapy Dosage; Radiotherapy, Adjuvant; Temozolomide; Treatment Outcome; Young Adult | 2014 |
Antitumor effect of fibrin glue containing temozolomide against malignant glioma.
Topics: Animals; Antineoplastic Agents, Alkylating; Apoptosis; Autophagy; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cellular Senescence; Dacarbazine; Delayed-Action Preparations; Drug Delivery Systems; Female; Fibrin Tissue Adhesive; Glioma; Mice; Mice, Inbred ICR; Mice, Nude; Neoplasm Recurrence, Local; Neoplasm Transplantation; Temozolomide | 2014 |
Temozolomide resistance in glioblastoma cells occurs partly through epidermal growth factor receptor-mediated induction of connexin 43.
Topics: Brain Neoplasms; Cell Line, Tumor; Cell Survival; Coloring Agents; Connexin 43; Dacarbazine; Drug Resistance, Neoplasm; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Gene Knockdown Techniques; Glioblastoma; Humans; JNK Mitogen-Activated Protein Kinases; Protein Binding; Signal Transduction; Temozolomide; Transcription Factor AP-1 | 2014 |
Fractionated radiotherapy is the main stimulus for the induction of cell death and of Hsp70 release of p53 mutated glioblastoma cell lines.
Topics: Antineoplastic Agents; Apoptosis; Brain Neoplasms; Cell Cycle; Cell Death; Cell Line, Tumor; Dacarbazine; Dose Fractionation, Radiation; G2 Phase; Glioblastoma; HMGB1 Protein; HSP70 Heat-Shock Proteins; Humans; Mutation; Necrosis; Temozolomide; Tumor Suppressor Protein p53; Valproic Acid | 2014 |
Liver toxicity during temozolomide chemotherapy caused by Chinese herbs.
Topics: Angiogenesis Inhibitors; Antibodies, Monoclonal, Humanized; Antineoplastic Agents, Alkylating; Bevacizumab; Brain Neoplasms; Camptothecin; Chemical and Drug Induced Liver Injury; Combined Modality Therapy; Dacarbazine; Disease Progression; Drugs, Chinese Herbal; Female; Glioblastoma; Herb-Drug Interactions; Humans; Irinotecan; Liver; Middle Aged; Phytotherapy; Temozolomide | 2014 |
First use of (18)F-labeled ML-10 PET to assess apoptosis change in a newly diagnosed glioblastoma multiforme patient before and early after therapy.
Topics: Aged; Antineoplastic Agents, Alkylating; Apoptosis; Brain Neoplasms; Dacarbazine; Glioblastoma; Humans; Male; Methylmalonic Acid; Positron-Emission Tomography; Temozolomide; Treatment Outcome | 2014 |
Durable therapeutic efficacy utilizing combinatorial blockade against IDO, CTLA-4, and PD-L1 in mice with brain tumors.
Topics: Animals; Antibodies, Monoclonal; Antineoplastic Agents; B7-H1 Antigen; Brain Neoplasms; Cell Line, Tumor; CTLA-4 Antigen; Dacarbazine; Disease Models, Animal; Drug Therapy, Combination; Glioma; Indoleamine-Pyrrole 2,3,-Dioxygenase; Mice; Mice, Knockout; T-Lymphocytes, Regulatory; Temozolomide | 2014 |
microRNA expression pattern modulates temozolomide response in GBM tumors with cancer stem cells.
Topics: Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cohort Studies; Dacarbazine; Drug Resistance, Neoplasm; Female; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Male; MicroRNAs; Middle Aged; Neoplastic Stem Cells; Survival Rate; Temozolomide; Treatment Outcome; Tumor Cells, Cultured | 2014 |
Combined EGFR and autophagy modulation impairs cell migration and enhances radiosensitivity in human glioblastoma cells.
Topics: Autophagy; Autophagy-Related Protein 7; Brain Neoplasms; Cell Line, Tumor; Cell Movement; Clone Cells; Dacarbazine; Drug Resistance, Neoplasm; ErbB Receptors; Gene Silencing; Glioblastoma; Humans; Radiation Tolerance; Radiation, Ionizing; RNA, Small Interfering; Sirolimus; Temozolomide; Transfection; Ubiquitin-Activating Enzymes | 2014 |
Combination treatment with theranostic nanoparticles for glioblastoma sensitization to TMZ.
Topics: Animals; Brain Neoplasms; Cell Line, Tumor; Cell Survival; Dacarbazine; Glioblastoma; Humans; Iron; Mice; Nanoparticles; O(6)-Methylguanine-DNA Methyltransferase; RNA, Small Interfering; Scorpion Venoms; Temozolomide; Xenograft Model Antitumor Assays | 2014 |
Hypofractionated chemoradiotherapy with temozolomide as a treatment option for glioblastoma patients with poor prognostic features.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Biopsy; Brain Neoplasms; Chemoradiotherapy; Dacarbazine; Disease-Free Survival; Dose Fractionation, Radiation; Female; Glioblastoma; Humans; Male; Middle Aged; Prognosis; Retrospective Studies; Temozolomide | 2015 |
Targeted therapies: Further delineating bevacizumab's response spectrum.
Topics: Angiogenesis Inhibitors; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Dacarbazine; Female; Glioblastoma; Humans; Male; Uterine Cervical Neoplasms | 2014 |
Glioblastoma: If this is the "Temozolomide Era" Where is the Evidence?
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Evidence-Based Medicine; Glioblastoma; Humans; Randomized Controlled Trials as Topic; Temozolomide | 2014 |
Glioblastoma treatment in the elderly in the temozolomide therapy era.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cohort Studies; Dacarbazine; Female; Follow-Up Studies; Glioblastoma; Humans; Male; Middle Aged; Retrospective Studies; Survival Rate; Temozolomide; Treatment Outcome; Young Adult | 2014 |
Temozolomide induces autophagy via ATM‑AMPK‑ULK1 pathways in glioma.
Topics: AMP-Activated Protein Kinases; Antineoplastic Agents, Alkylating; Ataxia Telangiectasia Mutated Proteins; Autophagy; Autophagy-Related Protein-1 Homolog; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; Glioma; Humans; Intracellular Signaling Peptides and Proteins; Microtubule-Associated Proteins; Morpholines; Protein Serine-Threonine Kinases; Pyrones; Signal Transduction; Temozolomide | 2014 |
IDH1 mutation and MGMT methylation status predict survival in patients with anaplastic astrocytoma treated with temozolomide-based chemoradiotherapy.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Astrocytoma; Biomarkers; Brain Neoplasms; Chemoradiotherapy; Dacarbazine; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Female; Follow-Up Studies; Humans; Isocitrate Dehydrogenase; Male; Middle Aged; Mutation; Prognosis; Promoter Regions, Genetic; Prospective Studies; Retrospective Studies; Temozolomide; Tumor Suppressor Proteins; Young Adult | 2014 |
Lessons learned from Radiation Therapy Oncology Group 0525 trial.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Female; Glioblastoma; Humans; Male | 2014 |
Reply to M.C. Chamberlain.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Female; Glioblastoma; Humans; Male | 2014 |
SDHB mutations are associated with response to temozolomide in patients with metastatic pheochromocytoma or paraganglioma.
Topics: Adrenal Gland Neoplasms; Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Biomarkers, Tumor; Brain Neoplasms; Dacarbazine; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Female; Follow-Up Studies; Humans; Male; Middle Aged; Mutation; Neoplasm Metastasis; Neoplasm Staging; Paraganglioma; Pheochromocytoma; Polymerase Chain Reaction; Prognosis; Promoter Regions, Genetic; Retrospective Studies; Succinate Dehydrogenase; Survival Rate; Temozolomide; Tumor Suppressor Proteins | 2014 |
Differential expression of miR200a-3p and miR21 in grade II-III and grade IV gliomas: evidence that miR200a-3p is regulated by O⁶-methylguanine methyltransferase and promotes temozolomide responsiveness.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; Drug Resistance, Neoplasm; Female; Glioblastoma; Humans; Male; MicroRNAs; Middle Aged; Neoplasm Grading; Temozolomide; Transcriptome; Tumor Suppressor Proteins | 2014 |
Experimental study of combined therapy for malignant glioma.
Topics: Animals; Animals, Outbred Strains; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Dacarbazine; Drug Screening Assays, Antitumor; Glioblastoma; Humans; Indoles; Neoplasm Transplantation; Nitrosourea Compounds; Oligodendroglioma; Organometallic Compounds; Photochemotherapy; Photosensitizing Agents; Rats, Wistar; Temozolomide | 2014 |
[Bevacizumab associated with radiotherapy and temozolomide as a first line treatment for high-grade gliomas: one answer but too many questions].
Topics: Angiogenesis Inhibitors; Antibodies, Monoclonal, Humanized; Antineoplastic Agents, Alkylating; Bevacizumab; Brain Neoplasms; Chemoradiotherapy; Dacarbazine; Glioma; Humans; Temozolomide | 2014 |
Combined PDK1 and CHK1 inhibition is required to kill glioblastoma stem-like cells in vitro and in vivo.
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Cell Death; Cell Line, Tumor; Checkpoint Kinase 1; Dacarbazine; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Glioblastoma; Humans; Mice; Mice, Inbred NOD; Mice, SCID; Molecular Targeted Therapy; Neoplastic Stem Cells; Protein Array Analysis; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Proteomics; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Signal Transduction; Small Molecule Libraries; Staurosporine; Temozolomide; Time Factors; Tumor Burden; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2014 |
Bak and Mcl-1 are essential for Temozolomide induced cell death in human glioma.
Topics: Antineoplastic Agents, Alkylating; Apoptosis; bcl-2 Homologous Antagonist-Killer Protein; Blotting, Western; Brain Neoplasms; Cell Cycle; Cell Proliferation; Dacarbazine; Glioma; Humans; Myeloid Cell Leukemia Sequence 1 Protein; Proto-Oncogene Proteins c-bcl-2; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Small Interfering; Temozolomide; Tumor Cells, Cultured | 2014 |
A nanoparticle carrying the p53 gene targets tumors including cancer stem cells, sensitizes glioblastoma to chemotherapy and improves survival.
Topics: Animals; Antineoplastic Agents; Apoptosis; Blood-Brain Barrier; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; Drug Resistance, Neoplasm; Genetic Therapy; Glioblastoma; Humans; Mice; Microscopy, Atomic Force; Nanomedicine; Nanoparticles; Neoplasm Recurrence, Local; Neoplasm Transplantation; Neoplastic Stem Cells; Temozolomide; Treatment Outcome; Tumor Suppressor Protein p53 | 2014 |
Kinomic exploration of temozolomide and radiation resistance in Glioblastoma multiforme xenolines.
Topics: Animals; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; Drug Resistance, Neoplasm; Glioblastoma; Humans; Mice; Mice, Nude; Protein-Tyrosine Kinases; Radiation Tolerance; Temozolomide; Xenograft Model Antitumor Assays | 2014 |
Multiple cerebral hemorrhagic foci from metastases during temozolomide treatment in a patient with corticotroph pituitary carcinoma.
Topics: ACTH-Secreting Pituitary Adenoma; Adenoma; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cerebral Hemorrhage; Dacarbazine; Humans; Male; Middle Aged; Temozolomide | 2014 |
Elderly patients aged 65-75 years with glioblastoma multiforme may benefit from long course radiation therapy with temozolomide.
Topics: Age Factors; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Disease-Free Survival; Female; Glioblastoma; Humans; Male; Middle Aged; Prognosis; Retrospective Studies; Temozolomide; Treatment Outcome | 2014 |
Discordant in vitro and in vivo chemopotentiating effects of the PARP inhibitor veliparib in temozolomide-sensitive versus -resistant glioblastoma multiforme xenografts.
Topics: Animals; Antineoplastic Agents, Alkylating; Benzimidazoles; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; DNA Damage; Drug Resistance, Neoplasm; Gene Knockdown Techniques; Glioblastoma; Humans; Mice, Nude; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Temozolomide; Xenograft Model Antitumor Assays | 2014 |
Synergy of enediyne antibiotic lidamycin and temozolomide in suppressing glioma growth with potentiated apoptosis induction.
Topics: Aminoglycosides; Animals; Antibiotics, Antineoplastic; Antineoplastic Agents, Alkylating; Apoptosis; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Dacarbazine; Drug Synergism; Enediynes; Glioma; Humans; Mice; Mice, Nude; Neoplasm Transplantation; Rats; Signal Transduction; Temozolomide | 2014 |
Bevacizumab for newly diagnosed glioblastoma.
Topics: Angiogenesis Inhibitors; Antibodies, Monoclonal, Humanized; Brain Neoplasms; Dacarbazine; Female; Glioblastoma; Humans; Male | 2014 |
[Intranasal administration of temozolomide for brain-targeting delivery: therapeutic effect on glioma in rats].
Topics: Administration, Intranasal; Animals; Antineoplastic Agents, Alkylating; Apoptosis; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; Drug Delivery Systems; Glioma; Magnetic Resonance Imaging; Neoplasm Transplantation; Rats; Rats, Wistar; Temozolomide | 2014 |
Bevacizumab for newly diagnosed glioblastoma.
Topics: Angiogenesis Inhibitors; Antibodies, Monoclonal, Humanized; Brain Neoplasms; Dacarbazine; Female; Glioblastoma; Humans; Male | 2014 |
MiR-124 governs glioma growth and angiogenesis and enhances chemosensitivity by targeting R-Ras and N-Ras.
Topics: Animals; Apoptosis; Brain; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Dacarbazine; Genes, ras; Glioma; Humans; Male; Mice; Mice, Nude; MicroRNAs; Neoplasm Invasiveness; Neovascularization, Pathologic; ras Proteins; Signal Transduction; Temozolomide | 2014 |
The effect of field strength on glioblastoma multiforme response in patients treated with the NovoTTF™-100A system.
Topics: Adult; Antineoplastic Agents, Alkylating; Brain Neoplasms; Combined Modality Therapy; Cranial Irradiation; Dacarbazine; Electric Stimulation Therapy; Female; Glioblastoma; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Staging; Prognosis; Radiotherapy; Temozolomide | 2014 |
Whole brain radiation therapy followed by intensity-modulated boosting treatment combined with concomitant temozolomide for brain metastases from non-small-cell lung cancer.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Carcinoma, Non-Small-Cell Lung; Combined Modality Therapy; Cranial Irradiation; Dacarbazine; Disease-Free Survival; Female; Humans; Kaplan-Meier Estimate; Lung Neoplasms; Male; Middle Aged; Proportional Hazards Models; Radiotherapy, Intensity-Modulated; Retrospective Studies; Temozolomide | 2014 |
Quercetin sensitizes human glioblastoma cells to temozolomide in vitro via inhibition of Hsp27.
Topics: Antineoplastic Agents, Alkylating; Brain; Brain Neoplasms; Caspase 3; Cell Line, Tumor; Dacarbazine; Glioblastoma; HSP27 Heat-Shock Proteins; Humans; Quercetin; Temozolomide | 2014 |
Longitudinal quality of life data: a comparison of continuous and ordinal approaches.
Topics: Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Appetite; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Female; Health Status; Humans; Longitudinal Studies; Middle Aged; Procarbazine; Quality of Life; Randomized Controlled Trials as Topic; Sleep Initiation and Maintenance Disorders; Sleep Stages; Surveys and Questionnaires; Temozolomide; Vincristine | 2014 |
Patterns of failure for glioblastoma multiforme following limited-margin radiation and concurrent temozolomide.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemoradiotherapy; Dacarbazine; Female; Follow-Up Studies; Glioblastoma; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Staging; Radiotherapy Dosage; Radiotherapy, Conformal; Retrospective Studies; Temozolomide; Treatment Failure; Young Adult | 2014 |
Molecular targeting of TRF2 suppresses the growth and tumorigenesis of glioblastoma stem cells.
Topics: Animals; Antineoplastic Agents, Alkylating; Brain Neoplasms; Carcinogenesis; Cell Differentiation; Cell Line, Tumor; Dacarbazine; Genetic Vectors; Glioblastoma; Humans; Mice, Inbred BALB C; Mice, Nude; Molecular Targeted Therapy; Neoplasm Transplantation; Neoplastic Stem Cells; Neural Cell Adhesion Molecule L1; Repressor Proteins; RNA, Messenger; RNA, Small Interfering; Telomeric Repeat Binding Protein 2; Temozolomide; Tubulin | 2014 |
Bevacizumab as secondline treatment of glioblastoma - worth the effort?
Topics: Adult; Aged; Angiogenesis Inhibitors; Antibodies, Monoclonal, Humanized; Bevacizumab; Brain Neoplasms; Camptothecin; Dacarbazine; Glioblastoma; Humans; Irinotecan; Middle Aged; Radiation-Sensitizing Agents; Retrospective Studies; Temozolomide; Vascular Endothelial Growth Factor A | 2014 |
Hyperoxia resensitizes chemoresistant glioblastoma cells to temozolomide through unfolded protein response.
Topics: Antineoplastic Agents, Alkylating; Apoptosis; Blotting, Western; Brain Neoplasms; Cell Proliferation; Combined Modality Therapy; Dacarbazine; Drug Resistance, Neoplasm; Endoplasmic Reticulum Stress; Glioblastoma; Humans; Hyperoxia; Procollagen-Proline Dioxygenase; Protein Disulfide-Isomerases; Temozolomide; Tumor Cells, Cultured; Unfolded Protein Response | 2014 |
TERT promoter mutations lead to high transcriptional activity under hypoxia and temozolomide treatment and predict poor prognosis in gliomas.
Topics: Antineoplastic Agents, Alkylating; Biomarkers, Tumor; Brain Neoplasms; Dacarbazine; Female; Follow-Up Studies; Gene Expression Regulation, Neoplastic; Glioma; Humans; Hypoxia; Male; Middle Aged; Mutation; Neoplasm Staging; Prognosis; Promoter Regions, Genetic; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Survival Rate; Telomerase; Temozolomide | 2014 |
MiR-143 acts as a tumor suppressor by targeting N-RAS and enhances temozolomide-induced apoptosis in glioma.
Topics: Animals; Antineoplastic Agents, Alkylating; Apoptosis; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Dacarbazine; Down-Regulation; Genes, ras; Genes, Tumor Suppressor; Glioma; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Nude; MicroRNAs; Molecular Targeted Therapy; Signal Transduction; Temozolomide; Transfection; Xenograft Model Antitumor Assays | 2014 |
A complex mechanism for HDGF-mediated cell growth, migration, invasion, and TMZ chemosensitivity in glioma.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents, Alkylating; Apoptosis; Brain Neoplasms; Cadherins; Carcinogenesis; Cell Line, Tumor; Cell Movement; Child; Dacarbazine; Epithelial-Mesenchymal Transition; Female; Glioma; Humans; Intercellular Signaling Peptides and Proteins; Male; Middle Aged; Proto-Oncogene Proteins c-akt; Signal Transduction; Temozolomide; Transforming Growth Factor beta; Young Adult | 2014 |
3-Dimensional magnetic resonance spectroscopic imaging at 3 Tesla for early response assessment of glioblastoma patients during external beam radiation therapy.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Aspartic Acid; Biomarkers, Tumor; Brain Neoplasms; Chemoradiotherapy; Choline; Contrast Media; Dacarbazine; Disease Progression; Disease-Free Survival; Female; Follow-Up Studies; Gadolinium; Glioblastoma; Humans; Imaging, Three-Dimensional; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Matched-Pair Analysis; Middle Aged; Neoplasm Recurrence, Local; Proportional Hazards Models; Radiotherapy Dosage; Temozolomide; Time Factors | 2014 |
The impact of concurrent temozolomide with adjuvant radiation and IDH mutation status among patients with anaplastic astrocytoma.
Topics: Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Chemoradiotherapy, Adjuvant; Dacarbazine; Female; Follow-Up Studies; Humans; Isocitrate Dehydrogenase; Male; Middle Aged; Mutation; Neoplasm Staging; Prognosis; Radiotherapy, Adjuvant; Retrospective Studies; Survival Rate; Temozolomide | 2014 |
NEO212, temozolomide conjugated to perillyl alcohol, is a novel drug for effective treatment of a broad range of temozolomide-resistant gliomas.
Topics: Animals; Antineoplastic Agents; Apoptosis; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; DNA Damage; DNA Modification Methylases; DNA Repair Enzymes; Drug Resistance, Neoplasm; Glioma; Humans; Mice, Nude; Tumor Suppressor Proteins; Xenograft Model Antitumor Assays | 2014 |
Significant anti-tumor effect of bevacizumab in treatment of pineal gland glioblastoma multiforme.
Topics: Aged; Angiogenesis Inhibitors; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Bevacizumab; Brain Neoplasms; Chemotherapy, Adjuvant; Dacarbazine; Disease Progression; Fatal Outcome; Glioblastoma; Humans; Magnetic Resonance Imaging; Male; Pineal Gland; Temozolomide; Tomography, X-Ray Computed; Treatment Outcome | 2014 |
miR-128 and miR-149 enhance the chemosensitivity of temozolomide by Rap1B-mediated cytoskeletal remodeling in glioblastoma.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cytoskeleton; Dacarbazine; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; MicroRNAs; rap GTP-Binding Proteins; Temozolomide; Up-Regulation | 2014 |
Analyzing temozolomide medication errors: potentially fatal.
Topics: Adverse Drug Reaction Reporting Systems; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Databases, Factual; Female; Follow-Up Studies; Glioblastoma; Humans; Male; Medication Errors; Middle Aged; Pharmaceutical Preparations; Prognosis; Retrospective Studies; Survival Rate; Temozolomide; United States | 2014 |
Treatment-related Acute Myeloid Leukaemia After Temozolomide for Glioblastoma Multiforme.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Female; Glioblastoma; Humans; Leukemia, Myeloid, Acute; Middle Aged; Temozolomide | 2014 |
Survival outcomes of giant cell glioblastoma: institutional experience in the management of 20 patients.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Disease Progression; Disease-Free Survival; Female; Glioblastoma; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Proportional Hazards Models; Radiotherapy, Adjuvant; Retrospective Studies; Temozolomide; Young Adult | 2014 |
Effect of neoadjuvant temozolomide upon volume reduction and resection of diffuse low-grade glioma.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Female; Follow-Up Studies; Glioma; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Neoadjuvant Therapy; Neoplasm Grading; Neurosurgical Procedures; Prognosis; Retrospective Studies; Survival Rate; Temozolomide; Tumor Burden | 2014 |
Toxicity profile of temozolomide in the treatment of 300 malignant glioma patients in Korea.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anorexia; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Female; Glioma; Hematologic Diseases; Humans; Male; Middle Aged; Nausea; Neoplasm Staging; Republic of Korea; Retrospective Studies; Severity of Illness Index; Sex Factors; Temozolomide; Vomiting; Young Adult | 2014 |
Potential novel role of bevacizumab in glioblastoma and cervical cancer.
Topics: Angiogenesis Inhibitors; Antibodies, Monoclonal, Humanized; Brain Neoplasms; Dacarbazine; Female; Glioblastoma; Humans; Male | 2014 |
Aplysin enhances temozolomide sensitivity in glioma cells by increasing miR-181 level.
Topics: Animals; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; Gene Expression Regulation, Neoplastic; Glioma; Humans; Hydrocarbons, Brominated; Male; MAP Kinase Kinase 1; Mice; Mice, Inbred BALB C; MicroRNAs; Sesquiterpenes; Temozolomide; Xenograft Model Antitumor Assays | 2014 |
Local delivery of cancer-cell glycolytic inhibitors in high-grade glioma.
Topics: Absorbable Implants; Animals; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Combined Modality Therapy; Dacarbazine; Dichloroacetic Acid; Drug Administration Routes; Drug Combinations; Drug Delivery Systems; Female; Glioblastoma; Glycolysis; Humans; Kaplan-Meier Estimate; Polymers; Pyruvates; Rats; Rats, Inbred F344; Temozolomide | 2015 |
Seizure reduction in a low-grade glioma: more than a beneficial side effect of temozolomide.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Disease-Free Survival; Endpoint Determination; Female; Glioma; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Seizures; Survival Analysis; Temozolomide | 2015 |
Are we done with dose-intense temozolomide in recurrent glioblastoma?
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Female; Glioma; Humans; Male | 2014 |
FANCD2 re-expression is associated with glioma grade and chemical inhibition of the Fanconi Anaemia pathway sensitises gliomas to chemotherapeutic agents.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Carmustine; Cell Line, Tumor; Curcumin; Dacarbazine; Fanconi Anemia; Fanconi Anemia Complementation Group D2 Protein; Glioma; Humans; Neoplasm Grading; Temozolomide | 2014 |
Survival in granular cell astrocytomas.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Child; Dacarbazine; Fatal Outcome; Female; Humans; Male; Middle Aged; Neurosurgical Procedures; Occipital Lobe; Radiotherapy, Adjuvant; Temozolomide | 2015 |
Radio-chemotherapy with temozolomide in elderly patients with glioblastoma. A mono-institutional experience.
Topics: Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemoradiotherapy; Dacarbazine; Female; Glioblastoma; Humans; Male; Proportional Hazards Models; Retrospective Studies; Temozolomide | 2014 |
Novel MSH6 mutations in treatment-naïve glioblastoma and anaplastic oligodendroglioma contribute to temozolomide resistance independently of MGMT promoter methylation.
Topics: Adult; Aged; Aged, 80 and over; Animals; Antineoplastic Agents, Alkylating; Blotting, Western; Brain Neoplasms; Dacarbazine; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; DNA-Binding Proteins; Drug Resistance, Neoplasm; Female; Genotype; Glioblastoma; Humans; Male; Mice; Middle Aged; Mutation; Oligodendroglioma; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; Temozolomide; Tumor Suppressor Proteins; Xenograft Model Antitumor Assays; Young Adult | 2014 |
Hypoxia-induced miR-497 decreases glioma cell sensitivity to TMZ by inhibiting apoptosis.
Topics: Antineoplastic Agents, Alkylating; Apoptosis; Apoptosis Regulatory Proteins; Base Sequence; Binding Sites; Brain Neoplasms; Cell Hypoxia; Cell Line, Tumor; Cell Survival; Dacarbazine; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Gene Expression Regulation, Neoplastic; Glioma; HEK293 Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; MicroRNAs; Response Elements; RNA Interference; RNA-Binding Proteins; Temozolomide; Transcription, Genetic; Transcriptional Activation | 2014 |
Exogenous IGFBP-2 promotes proliferation, invasion, and chemoresistance to temozolomide in glioma cells via the integrin β1-ERK pathway.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Dacarbazine; Drug Resistance, Neoplasm; Extracellular Signal-Regulated MAP Kinases; Gene Expression; Glioma; Humans; Insulin-Like Growth Factor Binding Protein 2; Integrin beta1; MAP Kinase Signaling System; Neoplasm Invasiveness; Temozolomide; Tissue Array Analysis | 2014 |
Is the absolute value of O(6)-methylguanine-DNA methyltransferase gene messenger RNA a prognostic factor, and does it predict the results of treatment of glioblastoma with temozolomide?
Topics: Adult; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Disease-Free Survival; Female; Glioblastoma; Humans; Male; Middle Aged; O(6)-Methylguanine-DNA Methyltransferase; Prognosis; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Temozolomide | 2014 |
Treatment of poorly differentiated glioma using a combination of monoclonal antibodies to extracellular connexin-43 fragment, temozolomide, and radiotherapy.
Topics: Animals; Antibodies, Monoclonal; Antineoplastic Agents, Alkylating; Blood-Brain Barrier; Brain Neoplasms; Capillary Permeability; Combined Modality Therapy; Connexin 43; Dacarbazine; Drug Administration Schedule; Female; Gamma Rays; Glioblastoma; Mice; Mice, Inbred BALB C; Neoplasm Transplantation; Protein Structure, Tertiary; Rats; Rats, Wistar; Stereotaxic Techniques; Survival Analysis; Temozolomide; Tumor Burden | 2014 |
RIST: a potent new combination therapy for glioblastoma.
Topics: Adolescent; Animals; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Camptothecin; Cell Line, Tumor; Child; Dacarbazine; Female; Glioblastoma; Humans; Indoles; Irinotecan; Male; Membrane Potential, Mitochondrial; Mice, Inbred NOD; Molecular Targeted Therapy; Pyrroles; Sirolimus; Sunitinib; Temozolomide; Xenograft Model Antitumor Assays | 2015 |
RNA-seq of 272 gliomas revealed a novel, recurrent PTPRZ1-MET fusion transcript in secondary glioblastomas.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents, Alkylating; Blotting, Western; Brain Neoplasms; Cell Line, Tumor; Chemoradiotherapy; Dacarbazine; Female; Gene Expression Regulation, Neoplastic; Glioblastoma; Glioma; HEK293 Cells; Humans; Introns; Male; Middle Aged; Oncogene Proteins, Fusion; Proto-Oncogene Proteins c-met; Receptor-Like Protein Tyrosine Phosphatases, Class 5; Reverse Transcriptase Polymerase Chain Reaction; Sequence Analysis, RNA; Temozolomide; Translocation, Genetic; Young Adult | 2014 |
Clinicopathological and molecular features of malignant optic pathway glioma in an adult.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Disease Progression; Female; Glioma; Humans; Isocitrate Dehydrogenase; Middle Aged; Optic Nerve Glioma; Radiosurgery; Temozolomide; Vision Disorders; Visual Fields | 2015 |
Low-dose rate stereotactic iodine-125 brachytherapy for the treatment of inoperable primary and recurrent glioblastoma: single-center experience with 201 cases.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brachytherapy; Brain Neoplasms; Chemotherapy, Adjuvant; Dacarbazine; Female; Follow-Up Studies; Glioblastoma; Humans; Iodine Radioisotopes; Male; Middle Aged; Neoplasm Recurrence, Local; Prognosis; Survival Analysis; Temozolomide; Treatment Outcome; Young Adult | 2014 |
Cilengitide in glioblastoma: when did it fail?
Topics: Brain Neoplasms; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; Female; Glioblastoma; Humans; Male; Snake Venoms; Temozolomide; Tumor Suppressor Proteins | 2014 |
Primary brain tumors: introduction.
Topics: Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Bevacizumab; Brain Neoplasms; Dacarbazine; Diagnostic Imaging; Humans; Molecular Diagnostic Techniques; Neurosurgical Procedures; Temozolomide | 2014 |
Temozolomide in low-grade gliomas: living longer and better.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Female; Glioma; Humans; Male; Seizures; Temozolomide | 2015 |
Nocardia abscesses mimicking tumor progression in gliomatosis cerebri responding to temozolomide.
Topics: Aged; Antineoplastic Agents, Alkylating; Brain; Brain Abscess; Brain Neoplasms; Dacarbazine; Humans; Magnetic Resonance Imaging; Male; Neoplasms, Neuroepithelial; Nocardia Infections; Temozolomide | 2015 |
The butterfly effect on glioblastoma: is volumetric extent of resection more effective than biopsy for these tumors?
Topics: Antineoplastic Agents, Alkylating; Biopsy, Needle; Brain; Brain Neoplasms; Dacarbazine; Female; Glioblastoma; Humans; Male; Middle Aged; Multivariate Analysis; Prognosis; Retrospective Studies; Survival Analysis; Temozolomide; Tertiary Care Centers; Treatment Outcome | 2014 |
Molecular imaging coupled to pattern recognition distinguishes response to temozolomide in preclinical glioblastoma.
Topics: Animals; Antineoplastic Agents, Alkylating; Apoptosis; Brain; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; Drug Administration Schedule; Female; Glioblastoma; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Metabolome; Mice; Mice, Inbred C57BL; Mitosis; Pattern Recognition, Automated; Temozolomide; Tumor Burden | 2014 |
VAMP8 facilitates cellular proliferation and temozolomide resistance in human glioma cells.
Topics: Antineoplastic Agents, Alkylating; Autophagy; Biomarkers, Tumor; Brain Neoplasms; Cell Cycle; Cell Proliferation; Dacarbazine; Drug Resistance, Neoplasm; Glioma; Humans; Oncogene Proteins; R-SNARE Proteins; Temozolomide | 2015 |
SapC-DOPS-induced lysosomal cell death synergizes with TMZ in glioblastoma.
Topics: Animals; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cell Death; Cell Line, Tumor; Dacarbazine; Drug Synergism; Glioblastoma; Humans; Lysosomes; Mice; Mice, Nude; Nanostructures; Phosphatidylserines; Random Allocation; Saposins; Temozolomide; Xenograft Model Antitumor Assays | 2014 |
CUSP9* treatment protocol for recurrent glioblastoma: aprepitant, artesunate, auranofin, captopril, celecoxib, disulfiram, itraconazole, ritonavir, sertraline augmenting continuous low dose temozolomide.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Aprepitant; Artemisinins; Artesunate; Auranofin; Brain Neoplasms; Captopril; Celecoxib; Dacarbazine; Disulfiram; Glioblastoma; Humans; Itraconazole; Molecular Targeted Therapy; Morpholines; Neoplasm Recurrence, Local; Pyrazoles; Ritonavir; Sertraline; Signal Transduction; Sulfonamides; Temozolomide; Treatment Outcome | 2014 |
Ficus carica latex prevents invasion through induction of let-7d expression in GBM cell lines.
Topics: Antineoplastic Agents; Apoptosis; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Chemical Fractionation; Dacarbazine; Ficus; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; In Situ Nick-End Labeling; Latex; MicroRNAs; Models, Biological; Neoplasm Invasiveness; Neovascularization, Physiologic; Phytotherapy; Plant Extracts; Temozolomide | 2015 |
Glioblastoma recurrence patterns after radiation therapy with regard to the subventricular zone.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Child; Child, Preschool; Dacarbazine; Disease-Free Survival; Female; Glioblastoma; Humans; Karnofsky Performance Status; Lateral Ventricles; Magnetic Resonance Imaging; Male; Middle Aged; Neoplasm Recurrence, Local; Retrospective Studies; Temozolomide; Young Adult | 2014 |
Annexin A5 promotes invasion and chemoresistance to temozolomide in glioblastoma multiforme cells.
Topics: Annexin A5; Antineoplastic Agents, Alkylating; Apoptosis; Brain Neoplasms; Cadherins; Cell Line, Tumor; Dacarbazine; Drug Resistance, Neoplasm; Gene Expression; Gene Knockdown Techniques; Glioblastoma; Humans; Matrix Metalloproteinase 2; Neoplasm Invasiveness; Phosphorylation; Proto-Oncogene Proteins c-akt; Snail Family Transcription Factors; Temozolomide; Transcription Factors; Twist-Related Protein 1 | 2014 |
Asiatic acid induces endoplasmic reticulum stress and apoptotic death in glioblastoma multiforme cells both in vitro and in vivo.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Male; Mice; Mice, Nude; Pentacyclic Triterpenes; Temozolomide; Tumor Burden; Xenograft Model Antitumor Assays | 2015 |
A sphingosine kinase inhibitor combined with temozolomide induces glioblastoma cell death through accumulation of dihydrosphingosine and dihydroceramide, endoplasmic reticulum stress and autophagy.
Topics: Antineoplastic Agents; Apoptosis; Autophagy; Brain Neoplasms; Cell Death; Cell Line, Tumor; Ceramides; Dacarbazine; Drug Resistance, Neoplasm; Drug Therapy, Combination; Endoplasmic Reticulum Stress; Enzyme Inhibitors; Glioblastoma; Humans; Phosphotransferases (Alcohol Group Acceptor); Sphingosine; Temozolomide | 2014 |
Inhibition of Na+/K+-ATPase induces hybrid cell death and enhanced sensitivity to chemotherapy in human glioblastoma cells.
Topics: Antineoplastic Agents; Apoptosis; Brain Neoplasms; Calcium; Cell Line, Tumor; Dacarbazine; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Gene Knockdown Techniques; Glioblastoma; Humans; Membrane Potential, Mitochondrial; Ouabain; Sodium; Sodium-Potassium-Exchanging ATPase; Temozolomide; Valinomycin | 2014 |
Radiation therapy dose escalation for glioblastoma multiforme in the era of temozolomide.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Disease-Free Survival; Dose Fractionation, Radiation; Female; Follow-Up Studies; Glioblastoma; Humans; Maintenance Chemotherapy; Male; Middle Aged; Radiotherapy Planning, Computer-Assisted; Temozolomide; Treatment Outcome; Young Adult | 2014 |
Concomitant treatment with temozolomide enhances apoptotic cell death in glioma cells induced by photodynamic therapy with talaporfin sodium.
Topics: Antineoplastic Agents, Alkylating; Apoptosis; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; Drug Therapy, Combination; Glioma; Humans; Photochemotherapy; Photosensitizing Agents; Porphyrins; Temozolomide; Treatment Outcome | 2014 |
A co-culture model with brain tumor-specific bioluminescence demonstrates astrocyte-induced drug resistance in glioblastoma.
Topics: Astrocytes; Brain Neoplasms; Cell Compartmentation; Cell Count; Cell Line, Tumor; Cell Survival; Coculture Techniques; Dacarbazine; Doxorubicin; Drug Resistance, Neoplasm; Glioblastoma; Humans; Luminescence; Models, Biological; Reproducibility of Results; Spheroids, Cellular; Stromal Cells; Temozolomide | 2014 |
ADC texture--an imaging biomarker for high-grade glioma?
Topics: Adult; Age Factors; Aged; Antineoplastic Agents, Alkylating; Brain; Brain Neoplasms; Chemoradiotherapy, Adjuvant; Dacarbazine; Diffusion Magnetic Resonance Imaging; Disease Progression; Follow-Up Studies; Glioma; Humans; Image Interpretation, Computer-Assisted; Middle Aged; Multivariate Analysis; Neoplasm Grading; Principal Component Analysis; Prognosis; Survival Analysis; Temozolomide; Treatment Outcome | 2014 |
Retrospective analysis of safety and feasibility of a 3 days on/11 days off temozolomide dosing regimen in recurrent adult malignant gliomas.
Topics: Administration, Oral; Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Drug Administration Schedule; Female; Glioma; Humans; Karnofsky Performance Status; Magnetic Resonance Imaging; Male; Middle Aged; Retrospective Studies; Temozolomide; Time Factors | 2014 |
Incidence of Pneumocystis jirovecii pneumonia after temozolomide for CNS malignancies without prophylaxis.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Child; Dacarbazine; Female; Glioblastoma; Humans; Longitudinal Studies; Male; Middle Aged; Pneumonia, Pneumocystis; Retrospective Studies; T-Lymphocytes; Temozolomide; Young Adult | 2014 |
Improvement in treatment results of glioblastoma over the last three decades and beneficial factors.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemotherapy, Adjuvant; Dacarbazine; Female; Glioblastoma; Humans; Karnofsky Performance Status; Male; Temozolomide | 2015 |
Dual mTORC1/2 blockade inhibits glioblastoma brain tumor initiating cells in vitro and in vivo and synergizes with temozolomide to increase orthotopic xenograft survival.
Topics: Animals; Antineoplastic Agents; Apoptosis; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dacarbazine; Disease Models, Animal; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Drug Synergism; ErbB Receptors; Glioblastoma; Humans; Mechanistic Target of Rapamycin Complex 1; Mechanistic Target of Rapamycin Complex 2; Mice; Multiprotein Complexes; Mutation; Neoplastic Stem Cells; Promoter Regions, Genetic; Protein Kinase Inhibitors; PTEN Phosphohydrolase; Signal Transduction; Temozolomide; TOR Serine-Threonine Kinases; Tumor Burden; Tumor Suppressor Proteins; Xenograft Model Antitumor Assays | 2014 |
Glioblastoma treated with concurrent radiation therapy and temozolomide chemotherapy: differentiation of true progression from pseudoprogression with quantitative dynamic contrast-enhanced MR imaging.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Combined Modality Therapy; Contrast Media; Dacarbazine; Disease Progression; Female; Glioblastoma; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Prospective Studies; Temozolomide; Treatment Outcome | 2015 |
Downregulation of BRCA1-BRCA2-containing complex subunit 3 sensitizes glioma cells to temozolomide.
Topics: Animals; Antineoplastic Agents, Alkylating; Apoptosis; Blotting, Western; Brain Neoplasms; Cell Proliferation; Dacarbazine; Deubiquitinating Enzymes; Down-Regulation; Drug Resistance, Neoplasm; Fluorescent Antibody Technique; Gene Expression Regulation, Neoplastic; Glioma; Humans; Immunoenzyme Techniques; Membrane Proteins; Neoplasm Grading; Rats; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Small Interfering; Temozolomide; Tumor Cells, Cultured | 2014 |
Intracranial microcapsule chemotherapy delivery for the localized treatment of rodent metastatic breast adenocarcinoma in the brain.
Topics: Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Capsules; Caspase 3; Dacarbazine; Doxorubicin; Female; Humans; Mammary Neoplasms, Experimental; Neoplasm Metastasis; Neoplasm Proteins; Rats; Rats, Inbred F344; Temozolomide | 2014 |
Estrogen receptor β agonist enhances temozolomide sensitivity of glioma cells by inhibiting PI3K/AKT/mTOR pathway.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Line, Tumor; Cell Survival; Dacarbazine; Estrogen Receptor beta; Flavanones; Glioma; Humans; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; RNA Interference; RNA, Small Interfering; Signal Transduction; Temozolomide; TOR Serine-Threonine Kinases | 2015 |
Comparison of ADC metrics and their association with outcome for patients with newly diagnosed glioblastoma being treated with radiation therapy, temozolomide, erlotinib and bevacizumab.
Topics: Adult; Aged; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Bevacizumab; Brain; Brain Neoplasms; Clinical Trials, Phase II as Topic; Combined Modality Therapy; Dacarbazine; Erlotinib Hydrochloride; Follow-Up Studies; Glioblastoma; Humans; Image Processing, Computer-Assisted; Kaplan-Meier Estimate; Magnetic Resonance Imaging; Middle Aged; Outcome Assessment, Health Care; Prognosis; Quinazolines; Temozolomide; Young Adult | 2015 |
Evaluation of novel imidazotetrazine analogues designed to overcome temozolomide resistance and glioblastoma regrowth.
Topics: Aniline Compounds; Animals; Antineoplastic Agents, Alkylating; Ataxia Telangiectasia Mutated Proteins; Brain Neoplasms; Cell Cycle; Cell Line, Tumor; Dacarbazine; DNA Damage; DNA Modification Methylases; DNA Repair Enzymes; Drug Resistance, Neoplasm; Fanconi Anemia Complementation Group D2 Protein; Gene Expression Regulation, Neoplastic; Glioblastoma; Heterocyclic Compounds, 2-Ring; Humans; Mice; Mice, Inbred C57BL; Neoplasm Recurrence, Local; Temozolomide; Tumor Suppressor Proteins; Xenograft Model Antitumor Assays | 2015 |
Glutathione depletion sensitizes cisplatin- and temozolomide-resistant glioma cells in vitro and in vivo.
Topics: Animals; Apoptosis; Brain Neoplasms; Buthionine Sulfoximine; Cell Line, Tumor; Cell Survival; Cisplatin; Dacarbazine; Disease Progression; DNA Damage; DNA Repair; Drug Resistance, Neoplasm; Female; Glioma; Glutathione; Humans; Mice, Nude; Temozolomide; Tumor Suppressor Protein p53 | 2014 |
Livin contributes to tumor hypoxia-induced resistance to cytotoxic therapies in glioblastoma multiforme.
Topics: Adaptor Proteins, Signal Transducing; Animals; Antineoplastic Agents, Alkylating; Apoptosis; Brain Neoplasms; Cell Hypoxia; Dacarbazine; Drug Resistance, Neoplasm; Gene Expression; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Inhibitor of Apoptosis Proteins; Male; Mice, Inbred BALB C; Mice, Nude; Neoplasm Proteins; Promoter Regions, Genetic; Protein Binding; Temozolomide; Xenograft Model Antitumor Assays | 2015 |
Combination of the mTOR inhibitor RAD001 with temozolomide and radiation effectively inhibits the growth of glioblastoma cells in culture.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Brain Neoplasms; Cell Proliferation; Cell Survival; Dacarbazine; DNA Damage; Dose-Response Relationship, Radiation; Everolimus; Gamma Rays; Glioblastoma; Histones; Humans; Linear Energy Transfer; Sirolimus; Temozolomide; TOR Serine-Threonine Kinases | 2015 |
Suppressor of fused (Sufu) represses Gli1 transcription and nuclear accumulation, inhibits glioma cell proliferation, invasion and vasculogenic mimicry, improving glioma chemo-sensitivity and prognosis.
Topics: Adult; Animals; Brain Neoplasms; Cell Line, Tumor; Cell Nucleus; Cell Proliferation; Dacarbazine; Disease Progression; Down-Regulation; Female; Glioma; Humans; Male; Mice; Mice, Nude; Middle Aged; Neoplasm Invasiveness; Neoplasm Transplantation; Prognosis; Repressor Proteins; RNA, Small Interfering; Temozolomide; Transcription Factors; Treatment Outcome; Veratrum Alkaloids; Zinc Finger Protein GLI1 | 2014 |
Inhibition of EZH2 reverses chemotherapeutic drug TMZ chemosensitivity in glioblastoma.
Topics: Antineoplastic Agents, Alkylating; Apoptosis; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Enhancer of Zeste Homolog 2 Protein; G1 Phase Cell Cycle Checkpoints; Glioblastoma; Humans; Neoplasm Proteins; Polycomb Repressive Complex 2; RNA Interference; RNA, Messenger; Temozolomide; Time Factors; Transfection | 2014 |
Mutational analysis reveals the origin and therapy-driven evolution of recurrent glioma.
Topics: Antineoplastic Agents; Brain Neoplasms; Cell Transformation, Neoplastic; Dacarbazine; Glioma; Humans; Mutation; Neoplasm Recurrence, Local; Temozolomide | 2014 |
Prognosis prediction of measurable enhancing lesion after completion of standard concomitant chemoradiotherapy and adjuvant temozolomide in glioblastoma patients: application of dynamic susceptibility contrast perfusion and diffusion-weighted imaging.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemoradiotherapy; Chemotherapy, Adjuvant; Child; Contrast Media; Dacarbazine; Diffusion Magnetic Resonance Imaging; Female; Glioblastoma; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Outcome Assessment, Health Care; Prognosis; Radiography; Temozolomide; Young Adult | 2014 |
Modulation of A1 and A2B adenosine receptor activity: a new strategy to sensitise glioblastoma stem cells to chemotherapy.
Topics: Adenosine A1 Receptor Agonists; Adenosine A2 Receptor Agonists; Apoptosis; Brain Neoplasms; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Cell Separation; Cell Shape; Cell Survival; Dacarbazine; Glioblastoma; Humans; Ligands; Neoplastic Stem Cells; Receptor, Adenosine A1; Receptor, Adenosine A2B; Temozolomide | 2014 |
Medical treatment of orthotopic glioblastoma with transferrin-conjugated nanoparticles encapsulating zoledronic acid.
Topics: Animals; Apoptosis; Blood-Brain Barrier; Brain Neoplasms; Cell Growth Processes; Cell Line, Tumor; Dacarbazine; Diphosphonates; Drug Delivery Systems; Drug Resistance, Neoplasm; Glioblastoma; Humans; Imidazoles; Male; Mice; Mice, Inbred Strains; Nanoparticles; Nitrosourea Compounds; Organophosphorus Compounds; Temozolomide; Transferrin; Tumor Burden; Xenograft Model Antitumor Assays; Zoledronic Acid | 2014 |
Vanishing bile duct syndrome in the context of concurrent temozolomide for glioblastoma.
Topics: Antineoplastic Agents, Alkylating; Biopsy, Needle; Brain Neoplasms; Chemical and Drug Induced Liver Injury; Cholestyramine Resin; Common Bile Duct Diseases; Dacarbazine; Female; Follow-Up Studies; Glioblastoma; Humans; Immunohistochemistry; Jaundice; Liver Function Tests; Middle Aged; Syndrome; Temozolomide; Treatment Outcome; Ursodeoxycholic Acid | 2014 |
Knockdown of CDC2 expression inhibits proliferation, enhances apoptosis, and increases chemosensitivity to temozolomide in glioblastoma cells.
Topics: Adult; Aged; Antineoplastic Agents; Apoptosis; Blotting, Western; Brain Neoplasms; CDC2 Protein Kinase; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinases; Dacarbazine; Drug Resistance, Neoplasm; Female; Gene Knockdown Techniques; Glioblastoma; Humans; Immunohistochemistry; Kaplan-Meier Estimate; Male; Middle Aged; Proportional Hazards Models; Reverse Transcriptase Polymerase Chain Reaction; Temozolomide; Transfection | 2015 |
Long-term therapy with temozolomide is a feasible option for newly diagnosed glioblastoma: a single-institution experience with as many as 101 temozolomide cycles.
Topics: Adrenal Cortex Hormones; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Disease-Free Survival; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Female; Glioblastoma; Humans; Karnofsky Performance Status; Ki-67 Antigen; Longitudinal Studies; Male; Middle Aged; Proportional Hazards Models; Retrospective Studies; Sulfites; Temozolomide; Time Factors; Tumor Suppressor Proteins | 2014 |
Standard (60 Gy) or short-course (40 Gy) irradiation plus concomitant and adjuvant temozolomide for elderly patients with glioblastoma: a propensity-matched analysis.
Topics: Adrenal Cortex Hormones; Age Factors; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemoradiotherapy; Chemotherapy, Adjuvant; Dacarbazine; Disease-Free Survival; DNA Methylation; Drug Administration Schedule; Female; Glioblastoma; Humans; Karnofsky Performance Status; Male; O(6)-Methylguanine-DNA Methyltransferase; Propensity Score; Radiotherapy Dosage; Regression Analysis; Retrospective Studies; Temozolomide; Time Factors; Treatment Outcome | 2015 |
Combination of photodynamic therapy and temozolomide on glioma in a rat C6 glioma model.
Topics: Animals; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; Drug Therapy, Combination; Glioma; Hematoporphyrins; Male; Photochemotherapy; Photosensitizing Agents; Rats; Rats, Wistar; Temozolomide; Treatment Outcome | 2014 |
Factorial clinical trials: a new approach to phase II neuro-oncology studies.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Female; Glioblastoma; Humans; Isotretinoin; Male; Pyrazoles; Sulfonamides; Thalidomide | 2015 |
Does cilengitide deserve another chance?
Topics: Brain Neoplasms; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; Female; Glioblastoma; Humans; Male; Snake Venoms; Tumor Suppressor Proteins | 2014 |
Does cilengitide deserve another chance?-Authors' reply.
Topics: Brain Neoplasms; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; Female; Glioblastoma; Humans; Male; Snake Venoms; Tumor Suppressor Proteins | 2014 |
Prediction of clinical outcome in glioblastoma using a biologically relevant nine-microRNA signature.
Topics: Aged; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; Databases, Genetic; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Male; MicroRNAs; Middle Aged; Neoplasm Grading; Prognosis; Regression Analysis; Risk Factors; Survival Analysis; Temozolomide; Treatment Outcome | 2015 |
Olanzapine inhibits proliferation, migration and anchorage-independent growth in human glioblastoma cell lines and enhances temozolomide's antiproliferative effect.
Topics: Antineoplastic Agents, Alkylating; Antipsychotic Agents; Apoptosis; Benzodiazepines; Blotting, Western; Brain Neoplasms; Cell Adhesion; Cell Movement; Cell Proliferation; Dacarbazine; Drug Synergism; Glioblastoma; Humans; Olanzapine; Phosphoproteins; Protein Array Analysis; Temozolomide; Tumor Cells, Cultured | 2015 |
Glioblastoma multiforme and hepatitis B: do the right thing(s).
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Glioblastoma; Hepatitis B; Hepatitis B virus; Humans; Male; Middle Aged; Temozolomide; Virus Activation | 2014 |
miR-155 Regulates Glioma Cells Invasion and Chemosensitivity by p38 Isforms In Vitro.
Topics: Apoptosis; Brain Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Dacarbazine; Gene Knockdown Techniques; Glioblastoma; Humans; In Vitro Techniques; MicroRNAs; Mitogen-Activated Protein Kinase 13; Mitogen-Activated Protein Kinase 14; Oxidative Stress; Temozolomide | 2015 |
Chemotherapeutic effect of tamoxifen on temozolomide-resistant gliomas.
Topics: Animals; Antineoplastic Agents, Hormonal; Apoptosis; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Electron Transport Complex I; Glioma; Humans; Male; Methylation; Mitochondria; Promoter Regions, Genetic; Rats, Sprague-Dawley; Tamoxifen; Temozolomide; Tumor Suppressor Proteins | 2015 |
Autophagy inhibition improves the efficacy of curcumin/temozolomide combination therapy in glioblastomas.
Topics: Animals; Apoptosis; Autophagy; Brain Neoplasms; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Survival; Curcumin; Dacarbazine; Dose-Response Relationship, Drug; Drug Synergism; Glioblastoma; Humans; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Rats; Temozolomide | 2015 |
Silencing erythropoietin receptor on glioma cells reinforces efficacy of temozolomide and X-rays through senescence and mitotic catastrophe.
Topics: Animals; Antineoplastic Agents, Alkylating; Blotting, Western; Brain Neoplasms; Cell Cycle Checkpoints; Cell Hypoxia; Cell Line, Tumor; Cell Survival; Cellular Senescence; Chemoradiotherapy; Cyclin B1; Dacarbazine; Glioma; Humans; Immunohistochemistry; Male; Mice, Nude; Mitosis; Polyploidy; Receptors, Erythropoietin; RNA Interference; RNAi Therapeutics; Temozolomide; Treatment Outcome; Xenograft Model Antitumor Assays | 2015 |
Tamoxifen in combination with temozolomide induce a synergistic inhibition of PKC-pan in GBM cell lines.
Topics: Apoptosis; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Dacarbazine; Drug Synergism; Glioblastoma; Humans; Phosphorylation; Protein Kinase C; Tamoxifen; Temozolomide | 2015 |
Single cell-derived clonal analysis of human glioblastoma links functional and genomic heterogeneity.
Topics: Antineoplastic Agents; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; Drug Resistance, Neoplasm; Glioblastoma; Humans; Single-Cell Analysis; Temozolomide | 2015 |
Salvage therapy with lomustine for temozolomide refractory recurrent anaplastic astrocytoma: a retrospective study.
Topics: Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Biomarkers, Tumor; Brain Neoplasms; Dacarbazine; Disease-Free Survival; Drug Resistance, Neoplasm; Female; Humans; Lomustine; Male; Middle Aged; Neoplasm Recurrence, Local; Retrospective Studies; Salvage Therapy; Temozolomide; Young Adult | 2015 |
Erastin sensitizes glioblastoma cells to temozolomide by restraining xCT and cystathionine-γ-lyase function.
Topics: Amino Acid Transport System y+; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Biological Transport; Brain Neoplasms; Cell Line, Tumor; Cell Survival; Cystathionine gamma-Lyase; Cysteine; Dacarbazine; Drug Resistance, Neoplasm; Enzyme Activation; Glioblastoma; Glutathione; Humans; NF-E2-Related Factor 2; Piperazines; Reactive Oxygen Species; RNA Interference; RNA, Small Interfering; Sulfasalazine; Temozolomide | 2015 |
Effects of hnRNP A2/B1 Knockdown on Inhibition of Glioblastoma Cell Invasion, Growth and Survival.
Topics: Brain Neoplasms; Cell Adhesion; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dacarbazine; Drug Resistance, Neoplasm; Female; Gene Knockdown Techniques; Glioblastoma; Heterogeneous-Nuclear Ribonucleoprotein Group A-B; Humans; Immunohistochemistry; Male; Matrix Metalloproteinases; Middle Aged; Neoplasm Invasiveness; STAT3 Transcription Factor; Temozolomide; Tumor Stem Cell Assay | 2016 |
Diffusion and perfusion MRI to differentiate treatment-related changes including pseudoprogression from recurrent tumors in high-grade gliomas with histopathologic evidence.
Topics: Aged; Antineoplastic Agents; Brain Diseases; Brain Neoplasms; Dacarbazine; Disease Progression; Female; Glioma; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Neoplasm Grading; Neoplasm Recurrence, Local; Neurosurgical Procedures; Radiotherapy; Retrospective Studies; Temozolomide | 2015 |
Temozolomide resistance in glioblastoma occurs by miRNA-9-targeted PTCH1, independent of sonic hedgehog level.
Topics: 3' Untranslated Regions; Animals; Antineoplastic Agents, Alkylating; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Blotting, Western; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Glioblastoma; Hedgehog Proteins; HEK293 Cells; Humans; MicroRNAs; Neoplasm Proteins; Patched Receptors; Patched-1 Receptor; Receptors, Cell Surface; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Signal Transduction; Temozolomide | 2015 |
Outcome of salvage treatment for recurrent glioblastoma.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemoradiotherapy; Chemotherapy, Adjuvant; Dacarbazine; Disease Progression; Disease-Free Survival; Female; Glioblastoma; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Radiosurgery; Reoperation; Retrospective Studies; Salvage Therapy; Temozolomide; Treatment Outcome | 2015 |
Targeting miR-381-NEFL axis sensitizes glioblastoma cells to temozolomide by regulating stemness factors and multidrug resistance factors.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Dacarbazine; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Glioblastoma; HEK293 Cells; Humans; Kruppel-Like Factor 4; MicroRNAs; Neoplastic Stem Cells; Neurofilament Proteins; Proteomics; RNA Interference; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tandem Mass Spectrometry; Temozolomide; Time Factors; Transfection; Two-Dimensional Difference Gel Electrophoresis | 2015 |
Biological tumor volume in 18FET-PET before radiochemotherapy correlates with survival in GBM.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain; Brain Neoplasms; Chemoradiotherapy; Combined Modality Therapy; Dacarbazine; Disease-Free Survival; Female; Glioblastoma; Humans; Longitudinal Studies; Male; Microsurgery; Middle Aged; Neurosurgical Procedures; Positron-Emission Tomography; Prospective Studies; Temozolomide; Treatment Outcome; Tumor Burden; Tyrosine | 2015 |
Clinical benefit in recurrent glioblastoma from adjuvant NovoTTF-100A and TCCC after temozolomide and bevacizumab failure: a preliminary observation.
Topics: Adult; Aged; Angiogenesis Inhibitors; Antimetabolites, Antineoplastic; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Brain Neoplasms; Capecitabine; Celecoxib; Combined Modality Therapy; Dacarbazine; Electric Stimulation Therapy; Female; Glioblastoma; Humans; Lomustine; Male; Middle Aged; Neoplasm Recurrence, Local; Temozolomide; Thioguanine; Treatment Failure | 2015 |
p53 upregulated modulator of apoptosis sensitizes drug-resistant U251 glioblastoma stem cells to temozolomide through enhanced apoptosis.
Topics: AC133 Antigen; Animals; Antigens, CD; Antineoplastic Agents, Alkylating; Apoptosis; Apoptosis Regulatory Proteins; bcl-2-Associated X Protein; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Dacarbazine; Disease Models, Animal; DNA Modification Methylases; DNA Repair Enzymes; Drug Resistance, Neoplasm; Female; Gene Expression; Glioblastoma; Glycoproteins; Humans; Immunophenotyping; Mice; Neoplastic Stem Cells; Peptides; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Temozolomide; Transcription, Genetic; Tumor Suppressor Proteins; Xenograft Model Antitumor Assays | 2015 |
Glioma cells escaped from cytotoxicity of temozolomide and vincristine by communicating with human astrocytes.
Topics: Antineoplastic Agents; Apoptosis; Astrocytes; Brain Neoplasms; Calcium; Cell Communication; Coculture Techniques; Connexin 43; Dacarbazine; Drug Resistance, Neoplasm; Gap Junctions; Gene Knockdown Techniques; Glioma; Humans; Temozolomide; Tumor Microenvironment; Vincristine | 2015 |
Impact of 1p/19q codeletion and histology on outcomes of anaplastic gliomas treated with radiation therapy and temozolomide.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Chemoradiotherapy; Chromosome Deletion; Chromosomes, Human, Pair 1; Chromosomes, Human, Pair 19; Dacarbazine; Female; Gene Deletion; Genetic Predisposition to Disease; Glioma; Humans; Male; Middle Aged; Missouri; Prevalence; Radiotherapy Dosage; Retrospective Studies; Risk Factors; Survival Rate; Temozolomide; Treatment Outcome; Young Adult | 2015 |
Dose escalation for GBM in the temozolamide era: in regard to Badiyan et al.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Female; Glioblastoma; Humans; Male | 2015 |
In reply to Gondi and Mehta.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Female; Glioblastoma; Humans; Male | 2015 |
Combined anti-Galectin-1 and anti-EGFR siRNA-loaded chitosan-lipid nanocapsules decrease temozolomide resistance in glioblastoma: in vivo evaluation.
Topics: Animals; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Line, Tumor; Chitosan; Dacarbazine; Drug Delivery Systems; Drug Resistance, Neoplasm; ErbB Receptors; Female; Galectin 1; Gene Silencing; Glioblastoma; Humans; Lipids; Mice, Nude; Nanocapsules; RNA, Small Interfering; Temozolomide; Tumor Burden | 2015 |
The effect of valproic acid in combination with irradiation and temozolomide on primary human glioblastoma cells.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cell Survival; Cells, Cultured; Chemoradiotherapy; Dacarbazine; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Dose-Response Relationship, Drug; Gene Expression Profiling; Glioblastoma; Humans; Mice, Inbred NOD; Mice, SCID; Microarray Analysis; Neoplasm Transplantation; Promoter Regions, Genetic; Radiation-Sensitizing Agents; Temozolomide; Tumor Suppressor Proteins; Valproic Acid | 2015 |
Elderly patients with glioblastoma multiforme treated with concurrent temozolomide and standard- versus abbreviated-course radiotherapy.
Topics: Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Female; Glioblastoma; Humans; Male; Multivariate Analysis; Promoter Regions, Genetic; Radiotherapy; Retrospective Studies; Survival Analysis; Temozolomide | 2015 |
Over-expression of tetraspanin 8 in malignant glioma regulates tumor cell progression.
Topics: Antineoplastic Agents, Alkylating; Apoptosis; Brain; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; Focal Adhesion Protein-Tyrosine Kinases; Gene Expression Regulation, Neoplastic; Glioma; Humans; Neoplasm Grading; RNA Interference; Temozolomide; Tetraspanins; Up-Regulation | 2015 |
Glioma cell VEGFR-2 confers resistance to chemotherapeutic and antiangiogenic treatments in PTEN-deficient glioblastoma.
Topics: Angiogenesis Inhibitors; Animals; Bevacizumab; Brain Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Dacarbazine; Disease-Free Survival; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Glioma; Humans; Kaplan-Meier Estimate; Mice, Nude; Neoplasm Invasiveness; Neovascularization, Pathologic; PTEN Phosphohydrolase; Signal Transduction; Temozolomide; Time Factors; Transfection; Tumor Burden; Vascular Endothelial Growth Factor Receptor-2; Xenograft Model Antitumor Assays | 2015 |
Imp2 regulates GBM progression by activating IGF2/PI3K/Akt pathway.
Topics: Brain Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Dacarbazine; Epithelial-Mesenchymal Transition; Female; Glioblastoma; Humans; Insulin-Like Growth Factor II; Male; Middle Aged; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; RNA-Binding Proteins; Signal Transduction; Temozolomide; Up-Regulation | 2015 |
Prognostic value of MGMT promoter status in non-resectable glioblastoma after adjuvant therapy.
Topics: Aged; Antineoplastic Agents, Alkylating; Biomarkers, Tumor; Biopsy, Needle; Brain Neoplasms; Chemotherapy, Adjuvant; Dacarbazine; Female; Glioblastoma; Humans; Male; Middle Aged; Neuronavigation; Neurosurgical Procedures; O(6)-Methylguanine-DNA Methyltransferase; Prognosis; Promoter Regions, Genetic; Prospective Studies; Retrospective Studies; Survival Analysis; Temozolomide; Treatment Outcome | 2015 |
When Hodgkin comes to a head: Hodgkin central nervous system involvement.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Brain Neoplasms; Dacarbazine; Doxorubicin; Hodgkin Disease; Humans; Male; Neoplasm Metastasis; Positron-Emission Tomography; Radiography; Vinblastine | 2015 |
Evolution of DNA repair defects during malignant progression of low-grade gliomas after temozolomide treatment.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Cohort Studies; Dacarbazine; Disease Progression; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; DNA Repair-Deficiency Disorders; Female; Glioma; Humans; Male; Mutation; Receptors, Immunologic; Statistics, Nonparametric; Temozolomide; Tumor Suppressor Proteins | 2015 |
Glioblastoma adaptation traced through decline of an IDH1 clonal driver and macro-evolution of a double-minute chromosome.
Topics: Adult; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemotherapy, Adjuvant; Chromosomes, Human; Cyclin-Dependent Kinase 4; Dacarbazine; Disease Progression; Fatal Outcome; Female; Genetic Association Studies; Genetic Predisposition to Disease; Glioblastoma; Humans; Imatinib Mesylate; Isocitrate Dehydrogenase; Mutation; Neoplasm Grading; Neoplasm Recurrence, Local; Neurosurgical Procedures; Phenotype; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-kit; Receptor, Platelet-Derived Growth Factor alpha; Temozolomide; Time Factors; Treatment Outcome | 2015 |
Genomically amplified Akt3 activates DNA repair pathway and promotes glioma progression.
Topics: Animals; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; Disease Progression; DNA Damage; DNA Repair; Drug Resistance, Neoplasm; Gene Amplification; Gene Expression Regulation, Neoplastic; Genome, Human; Glioma; Humans; Isoenzymes; Mice; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Radiation Tolerance; Signal Transduction; Temozolomide; Transcription, Genetic | 2015 |
EGFR amplified and overexpressing glioblastomas and association with better response to adjuvant metronomic temozolomide.
Topics: Administration, Metronomic; Adult; Analysis of Variance; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemotherapy, Adjuvant; Dacarbazine; Disease-Free Survival; ErbB Receptors; Female; Gene Amplification; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Neoplastic Stem Cells; Odds Ratio; Proportional Hazards Models; Temozolomide; Up-Regulation | 2015 |
Coexpression analysis of CD133 and CD44 identifies proneural and mesenchymal subtypes of glioblastoma multiforme.
Topics: AC133 Antigen; Antigens, CD; Biomarkers, Tumor; Brain Neoplasms; Cell Proliferation; Dacarbazine; Gene Expression Profiling; Glioblastoma; Glycoproteins; Humans; Hyaluronan Receptors; Mesoderm; Neoplastic Stem Cells; Neural Stem Cells; Peptides; Predictive Value of Tests; Temozolomide | 2015 |
Treatment results and prognostic factors for intracranial nongerminomatous germ cell tumors: single institute experience.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Brain Neoplasms; Chemotherapy, Adjuvant; Child; Child, Preschool; Cisplatin; Combined Modality Therapy; Craniospinal Irradiation; Dacarbazine; Disease-Free Survival; Etoposide; Female; Humans; Magnetic Resonance Imaging; Male; Neoplasms, Germ Cell and Embryonal; Neurosurgical Procedures; Prognosis; Retrospective Studies; Survival Rate; Temozolomide; Treatment Outcome; Vinblastine; Young Adult | 2015 |
The effect of silibinin in enhancing toxicity of temozolomide and etoposide in p53 and PTEN-mutated resistant glioma cell lines.
Topics: Antineoplastic Agents; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; Drug Resistance, Neoplasm; Drug Synergism; Etoposide; Genes, p53; Glioma; Humans; Inhibitor of Apoptosis Proteins; Mutation; PTEN Phosphohydrolase; Silybin; Silymarin; Survivin; Temozolomide | 2015 |
Decitabine nanoconjugate sensitizes human glioblastoma cells to temozolomide.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents, Alkylating; Apoptosis; Azacitidine; Biocompatible Materials; Boron Compounds; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; Decitabine; DNA Methylation; Drug Delivery Systems; Drug Synergism; Glioblastoma; Humans; Hydrogen-Ion Concentration; Hydrolysis; Kinetics; Lactic Acid; Magnetic Resonance Spectroscopy; Methacrylates; Methylmethacrylates; Micelles; Nanoconjugates; Polyethylene Glycols; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Spectrometry, Fluorescence; Temozolomide | 2015 |
Temozolomide nanoparticles for targeted glioblastoma therapy.
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; Drug Carriers; Drug Delivery Systems; Glioblastoma; Humans; Mice; Mice, Inbred C57BL; Nanoparticles; Temozolomide | 2015 |
A transcriptomic signature mediated by HOXA9 promotes human glioblastoma initiation, aggressiveness and resistance to temozolomide.
Topics: Animals; Brain Neoplasms; Cell Proliferation; Dacarbazine; Gene Expression; Glioblastoma; Homeodomain Proteins; Humans; Mice; Oncogenes; Prognosis; Temozolomide; Tissue Array Analysis; Transcriptome; Transfection; Xenograft Model Antitumor Assays | 2015 |
Elimination of cancer stem-like cells and potentiation of temozolomide sensitivity by Honokiol in glioblastoma multiforme cells.
Topics: Antineoplastic Agents; Apoptosis; Basic Helix-Loop-Helix Transcription Factors; Biphenyl Compounds; Brain Neoplasms; Cell Proliferation; Dacarbazine; Dose-Response Relationship, Drug; Down-Regulation; Drug Synergism; Drug Therapy, Combination; Glioblastoma; Homeodomain Proteins; Humans; Lignans; Neoplastic Stem Cells; Receptor, Notch3; Receptors, Notch; Temozolomide; Transcription Factor HES-1; Tumor Cells, Cultured | 2015 |
The evolving genomic landscape of recurrent gliomas.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; DNA Helicases; Genomics; Glioma; Humans; Isocitrate Dehydrogenase; Mutation; Neoplasm Recurrence, Local; Neurosurgical Procedures; Nuclear Proteins; Prognosis; Temozolomide; Tumor Suppressor Protein p53; X-linked Nuclear Protein | 2015 |
Post-surgical therapeutic approaches to glioblastoma patients submitted to biopsy (BA) or "partial" resection (PR): the possibilities to treat also them without renunciations. Study from the Brescia Neuro-Oncology Group.
Topics: Antineoplastic Agents, Alkylating; Biopsy; Brain Neoplasms; Dacarbazine; Glioblastoma; Humans; Middle Aged; Neurosurgical Procedures; Retrospective Studies; Temozolomide | 2015 |
Focused ultrasound with microbubbles increases temozolomide delivery in U87 transfected mice.
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; Disease Models, Animal; Drug Delivery Systems; Mice; Microbubbles; Neoplasms, Experimental; Temozolomide; Transfection; Ultrasonics | 2015 |
Preclinical impact of bevacizumab on brain and tumor distribution of irinotecan and temozolomide.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents, Alkylating; Antineoplastic Agents, Phytogenic; Bevacizumab; Brain; Brain Neoplasms; Camptothecin; Cell Line, Tumor; Dacarbazine; Female; Glioblastoma; Humans; Irinotecan; Mice; Mice, Nude; Neoplasm Transplantation; Temozolomide; Tissue Distribution | 2015 |
Identification of imaging biomarkers for the assessment of tumour response to different treatments in a preclinical glioma model.
Topics: Animals; Antineoplastic Agents; Biomarkers, Tumor; Brain Neoplasms; Carbonic Anhydrases; Cell Line, Tumor; Dacarbazine; Drug Evaluation, Preclinical; Female; Glioma; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Luminescent Proteins; Mice; Mice, Nude; Optical Imaging; Temozolomide | 2015 |
Temozolomide and radiotherapy versus radiotherapy alone in high grade gliomas: a very long term comparative study and literature review.
Topics: Adult; Aged; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Female; Glioma; Humans; Male; Middle Aged; Retrospective Studies; Temozolomide | 2015 |
The metalloprotease-disintegrin ADAM8 contributes to temozolomide chemoresistance and enhanced invasiveness of human glioblastoma cells.
Topics: ADAM Proteins; Antineoplastic Agents; Blotting, Western; Brain Neoplasms; Cell Separation; Cell Survival; Dacarbazine; Drug Resistance, Neoplasm; Enzyme-Linked Immunosorbent Assay; Fluorescence Resonance Energy Transfer; Glioblastoma; Humans; Immunoblotting; Membrane Proteins; Neoplasm Invasiveness; Real-Time Polymerase Chain Reaction; Temozolomide; Transcriptome | 2015 |
Hypofractionated versus standard radiation therapy with or without temozolomide for older glioblastoma patients.
Topics: Age Factors; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Dose Fractionation, Radiation; Female; Glioblastoma; Humans; Male; Multivariate Analysis; Propensity Score; Retrospective Studies; Selection Bias; Temozolomide | 2015 |
Epithelial-to-mesenchymal transition in paired human primary and recurrent glioblastomas.
Topics: Biomarkers, Tumor; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; Epithelial-Mesenchymal Transition; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Neoplasm Recurrence, Local; Temozolomide | 2015 |
The Effect of Timing of Concurrent Chemoradiation in Patients With Newly Diagnosed Glioblastoma.
Topics: Adult; Aged; Aged, 80 and over; Algorithms; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemoradiotherapy, Adjuvant; Cohort Studies; Dacarbazine; Disease-Free Survival; Female; Glioblastoma; Humans; Male; Middle Aged; Neurosurgical Procedures; Prognosis; Survival Analysis; Temozolomide; Treatment Outcome | 2015 |
Recurrence of glioblastoma after radio-chemotherapy is associated with an angiogenic switch to the CXCL12-CXCR4 pathway.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents, Alkylating; Benzylamines; Brain Neoplasms; Chemokine CXCL12; Chemoradiotherapy; Child; Child, Preschool; Cyclams; Dacarbazine; Disease Progression; Disease-Free Survival; Female; Gene Expression Profiling; Glioblastoma; Heterocyclic Compounds; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Immunohistochemistry; Kaplan-Meier Estimate; Male; Middle Aged; Neoplasm Recurrence, Local; Neovascularization, Pathologic; Proportional Hazards Models; Real-Time Polymerase Chain Reaction; Receptors, CXCR4; Retrospective Studies; Signal Transduction; Temozolomide; Time Factors; Tissue Culture Techniques; Treatment Outcome; Vascular Endothelial Growth Factor Receptor-2; Young Adult | 2015 |
Silencing of R-Spondin1 increases radiosensitivity of glioma cells.
Topics: Adult; Aged; Aged, 80 and over; Animals; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Astrocytes; Brain Neoplasms; Cell Line, Tumor; Combined Modality Therapy; Dacarbazine; Female; Gene Expression Regulation, Neoplastic; Gene Silencing; Glioma; Humans; Male; Mice; Mice, Nude; Middle Aged; Neoplasm Transplantation; Proportional Hazards Models; Radiation Tolerance; Radiotherapy; Rats; RNA, Small Interfering; Temozolomide; Thrombospondins; Treatment Outcome; Xenograft Model Antitumor Assays | 2015 |
Metformin inhibits growth of human glioblastoma cells and enhances therapeutic response.
Topics: Adenylate Kinase; Animals; Apoptosis; Autophagy; Brain Neoplasms; Cell Division; Cell Line, Tumor; Dacarbazine; Drug Synergism; Glioblastoma; Glycolysis; Humans; Metformin; Mice; Mice, Nude; Mitochondria; Temozolomide; Transcription Factors; Xenograft Model Antitumor Assays | 2015 |
MicroRNA profiling of Chinese primary glioblastoma reveals a temozolomide-chemoresistant subtype.
Topics: Adult; Antineoplastic Agents, Alkylating; Asian People; Biomarkers, Tumor; Brain Neoplasms; China; Cluster Analysis; Dacarbazine; Drug Resistance, Neoplasm; ErbB Receptors; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Isocitrate Dehydrogenase; Kaplan-Meier Estimate; Ki-67 Antigen; Male; MicroRNAs; Middle Aged; Mutation; Oligonucleotide Array Sequence Analysis; Predictive Value of Tests; Real-Time Polymerase Chain Reaction; Reproducibility of Results; Temozolomide; Treatment Outcome | 2015 |
ABT-888 enhances cytotoxic effects of temozolomide independent of MGMT status in serum free cultured glioma cells.
Topics: Apoptosis; Autophagy; Benzimidazoles; Brain Neoplasms; Culture Media, Serum-Free; Dacarbazine; DNA Breaks, Double-Stranded; DNA Modification Methylases; DNA Repair Enzymes; Glioma; Humans; Neoplastic Stem Cells; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Temozolomide; Tumor Cells, Cultured; Tumor Suppressor Proteins | 2015 |
Combined treatment of Nimotuzumab and rapamycin is effective against temozolomide-resistant human gliomas regardless of the EGFR mutation status.
Topics: Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dacarbazine; Drug Resistance, Neoplasm; ErbB Receptors; Glioblastoma; Humans; Mutation; Sirolimus; Temozolomide | 2015 |
The DNA damage/repair cascade in glioblastoma cell lines after chemotherapeutic agent treatment.
Topics: Antineoplastic Agents; Apoptosis; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Dacarbazine; DNA Damage; DNA Repair; DNA, Neoplasm; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance, Neoplasm; Glioblastoma; Humans; Paclitaxel; Temozolomide | 2015 |
Amino acid PET tracers are reliable markers of treatment responses to single-agent or combination therapies including temozolomide, interferon-β, and/or bevacizumab for glioblastoma.
Topics: Amino Acids; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Biomarkers, Tumor; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; Glioblastoma; Humans; Interferon-beta; Male; Positron-Emission Tomography; Radiopharmaceuticals; Rats; Rats, Inbred F344; Rats, Nude; Reproducibility of Results; Sensitivity and Specificity; Temozolomide; Tissue Distribution; Treatment Outcome | 2015 |
The MGMT promoter SNP rs16906252 is a risk factor for MGMT methylation in glioblastoma and is predictive of response to temozolomide.
Topics: Adult; Aged; Aged, 80 and over; Alleles; Antineoplastic Agents, Alkylating; Biomarkers; Brain Neoplasms; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; Female; Genotype; Glioblastoma; Humans; Kaplan-Meier Estimate; Male; Methylation; Middle Aged; Polymorphism, Single Nucleotide; Promoter Regions, Genetic; Risk Factors; Temozolomide; Treatment Outcome; Tumor Suppressor Proteins | 2015 |
Feasibility of the EORTC/NCIC Trial Protocol in a Neurosurgical Outpatient Unit: The Case for Neurosurgical Neuro-Oncology.
Topics: Adult; Aged; Aged, 80 and over; Ambulatory Care; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemoradiotherapy; Clinical Protocols; Cohort Studies; Combined Modality Therapy; Dacarbazine; Feasibility Studies; Female; Glioblastoma; Humans; Male; Middle Aged; Nervous System Neoplasms; Neurosurgery; Prospective Studies; Retrospective Studies; Survival Analysis; Temozolomide; Young Adult | 2015 |
Risk factors for glioblastoma therapy associated complications.
Topics: Age Factors; Antineoplastic Agents; Brain Neoplasms; Chemoradiotherapy, Adjuvant; Cohort Studies; Dacarbazine; Female; Glioblastoma; Humans; Intracranial Hemorrhages; Kaplan-Meier Estimate; Karnofsky Performance Status; Logistic Models; Male; Middle Aged; Motor Disorders; Multivariate Analysis; Neurosurgical Procedures; Odds Ratio; Postoperative Complications; Postoperative Hemorrhage; Prognosis; Psychotic Disorders; Retrospective Studies; Risk Factors; Seizures; Surgical Wound Infection; Temozolomide | 2015 |
SEL1L SNP rs12435998, a predictor of glioblastoma survival and response to radio-chemotherapy.
Topics: Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Blotting, Western; Brain Neoplasms; Cell Line, Tumor; Chemoradiotherapy; Dacarbazine; Doxorubicin; Genotype; Glioblastoma; Humans; Kaplan-Meier Estimate; Paclitaxel; Polymerase Chain Reaction; Polymorphism, Single Nucleotide; Proteins; Temozolomide; Valproic Acid | 2015 |
Treating anaplastic oligodendrogliomas and WHO grade 2 gliomas: PCV or temozolomide? The case for PCV.
Topics: Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Chemotherapy, Adjuvant; Clinical Trials as Topic; Dacarbazine; Evidence-Based Medicine; Glioma; Humans; Lomustine; Neoplasm Grading; Neoplasm Staging; Oligodendroglioma; Procarbazine; Prognosis; Radiotherapy, Adjuvant; Survival Analysis; Temozolomide; Treatment Outcome; Vincristine | 2015 |
Combination of the multipotent mesenchymal stromal cell transplantation with administration of temozolomide increases survival of rats with experimental glioblastoma.
Topics: Animals; Brain Neoplasms; Cell Line, Tumor; Combined Modality Therapy; Dacarbazine; Disease Models, Animal; Glioblastoma; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Rats; Rats, Wistar; Survival Rate; Temozolomide; Transplantation, Homologous | 2015 |
Chip-based analysis of exosomal mRNA mediating drug resistance in glioblastoma.
Topics: Animals; Biomarkers, Tumor; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; Drug Resistance, Neoplasm; Exosomes; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Immunomagnetic Separation; Mice, Nude; Microfluidics; RNA, Messenger; Temozolomide; Treatment Outcome | 2015 |
miR-20a mediates temozolomide-resistance in glioblastoma cells via negatively regulating LRIG1 expression.
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Dacarbazine; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Male; Membrane Glycoproteins; Mice, Nude; MicroRNAs; Temozolomide | 2015 |
Long-term Results of a Survey of Prolonged Adjuvant Treatment with Temozolomide in Patients with Glioblastoma (SV3 Study).
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemoradiotherapy; Dacarbazine; Glioblastoma; Health Care Surveys; Humans; Middle Aged; Retrospective Studies; Survival Analysis; Temozolomide | 2015 |
Swinging for the Fences: Long-Term Survival With Ipilimumab in Metastatic Melanoma.
Topics: Adrenal Insufficiency; Adult; Antibodies, Monoclonal; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cisplatin; Dacarbazine; Hormone Replacement Therapy; Humans; Hypopituitarism; Hypothyroidism; Interferon-alpha; Interleukin-2; Ipilimumab; Lung Neoplasms; Lymphatic Metastasis; Male; Melanoma; Neoplasm Staging; Parietal Lobe; Radiosurgery; Sentinel Lymph Node Biopsy; Shoulder; Skin Neoplasms; Treatment Outcome; Vinblastine | 2015 |
Survival benefit of levetiracetam in patients treated with concomitant chemoradiotherapy and adjuvant chemotherapy with temozolomide for glioblastoma multiforme.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Chemoradiotherapy; Chemotherapy, Adjuvant; Dacarbazine; Female; Glioblastoma; Humans; Kaplan-Meier Estimate; Levetiracetam; Male; Middle Aged; Piracetam; Proportional Hazards Models; Retrospective Studies; Temozolomide; Young Adult | 2015 |
Potentiation of temozolomide antitumor effect by purine receptor ligands able to restrain the in vitro growth of human glioblastoma stem cells.
Topics: Adenosine A3 Receptor Antagonists; Adenosine Triphosphate; Antineoplastic Agents, Alkylating; Apoptosis; Brain Neoplasms; Caspase Inhibitors; Cell Proliferation; Dacarbazine; Drug Synergism; Glioblastoma; Humans; Ligands; Neoplastic Stem Cells; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic; Receptors, Purinergic P1; Receptors, Purinergic P2X7; Temozolomide | 2015 |
Temozolomide-loaded photopolymerizable PEG-DMA-based hydrogel for the treatment of glioblastoma.
Topics: Animals; Antineoplastic Agents, Alkylating; Apoptosis; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Dacarbazine; Delayed-Action Preparations; Drug Delivery Systems; Female; Glioblastoma; Humans; Hydrogels; Light; Methacrylates; Mice, Nude; Microglia; Polyethylene Glycols; Temozolomide; Tumor Burden | 2015 |
Upfront chemotherapy and subsequent resection for molecularly defined gliomas.
Topics: Adult; Antineoplastic Agents; Brain Neoplasms; Chromosome Deletion; Chromosomes, Human, Pair 1; Dacarbazine; Disease-Free Survival; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Female; Glioma; Humans; Male; Middle Aged; Nitrosourea Compounds; Prospective Studies; Temozolomide; Treatment Outcome; Tumor Suppressor Proteins | 2015 |
Temozolomide induced bone marrow Suppression--A single institution outcome analysis and review of the literature.
Topics: Adolescent; Adult; Aged; Anemia, Aplastic; Antineoplastic Agents, Alkylating; Astrocytoma; Bone Marrow; Brain Neoplasms; Dacarbazine; Female; Humans; Male; Middle Aged; Survival Analysis; Temozolomide; Treatment Outcome | 2015 |
Impact of glycemia on survival of glioblastoma patients treated with radiation and temozolomide.
Topics: Antineoplastic Agents, Alkylating; Antineoplastic Agents, Hormonal; Brain Neoplasms; Dacarbazine; Dexamethasone; Female; Glioblastoma; Humans; Hyperglycemia; Kaplan-Meier Estimate; Male; Middle Aged; Retrospective Studies; Temozolomide | 2015 |
A Model to Predict the Feasibility of Concurrent Chemoradiotherapy With Temozolomide in Glioblastoma Multiforme Patients Over Age 65.
Topics: Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemoradiotherapy; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; Female; Glioblastoma; Humans; Male; Models, Biological; Promoter Regions, Genetic; Radiotherapy Dosage; Retrospective Studies; Survival Rate; Temozolomide; Tumor Suppressor Proteins | 2017 |
[Perampanel in the treatment of a patient with glioblastoma multiforme without IDH1 mutation and without MGMT promotor methylation].
Topics: Alkylating Agents; Brain Neoplasms; Dacarbazine; Epilepsies, Partial; Excitatory Amino Acid Antagonists; Glioblastoma; Humans; Isocitrate Dehydrogenase; Magnetic Resonance Imaging; Male; Methylation; Middle Aged; Mutation; Nitriles; O(6)-Methylguanine-DNA Methyltransferase; Promoter Regions, Genetic; Pyridones; Survival Analysis; Temozolomide | 2015 |
Adjuvant temozolomide-based chemoradiotherapy versus radiotherapy alone in patients with WHO III astrocytoma: The Mainz experience.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Chemoradiotherapy, Adjuvant; Combined Modality Therapy; Dacarbazine; Disease-Free Survival; Dose Fractionation, Radiation; Female; Germany; Humans; Male; Middle Aged; Neoplasm Grading; Neoplasm, Residual; Radiotherapy, Adjuvant; Retrospective Studies; Temozolomide | 2015 |
Clinical and Dosimetric Predictors of Acute Severe Lymphopenia During Radiation Therapy and Concurrent Temozolomide for High-Grade Glioma.
Topics: Acute Disease; Adult; Age Factors; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain; Brain Neoplasms; Chemotherapy, Adjuvant; Cranial Irradiation; Dacarbazine; Female; Glioma; Humans; Lymphocyte Count; Lymphopenia; Male; Middle Aged; Odds Ratio; Radiotherapy Dosage; Regression Analysis; Sex Factors; Temozolomide; Young Adult | 2015 |
Down regulation of Akirin-2 increases chemosensitivity in human glioblastomas more efficiently than Twist-1.
Topics: Antineoplastic Agents, Alkylating; Apoptosis; Brain Neoplasms; Caspase 3; Caspase 7; CD11b Antigen; Cell Line, Tumor; Cell Nucleus; Cytosol; Dacarbazine; DNA-Binding Proteins; Down-Regulation; Drug Resistance, Neoplasm; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Glial Fibrillary Acidic Protein; Glioblastoma; Human Umbilical Vein Endothelial Cells; Humans; Microscopy, Fluorescence; Nuclear Proteins; RNA Interference; Temozolomide; Transcription Factors; Twist-Related Protein 1; von Willebrand Factor | 2015 |
Impact of oligodendroglial component in glioblastoma (GBM-O): Is the outcome favourable than glioblastoma?
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemoradiotherapy, Adjuvant; Dacarbazine; Disease-Free Survival; Female; Glioblastoma; Humans; Karnofsky Performance Status; Male; Middle Aged; Neoplasms, Complex and Mixed; Neurosurgical Procedures; Oligodendroglioma; Prognosis; Temozolomide; Treatment Outcome; Young Adult | 2015 |
Metronomic chemotherapy with daily low-dose temozolomide and celecoxib in elderly patients with newly diagnosed glioblastoma multiforme: a retrospective analysis.
Topics: Aged; Aged, 80 and over; Antineoplastic Agents; Brain Neoplasms; Celecoxib; Chemoradiotherapy; Comorbidity; Cyclooxygenase 2 Inhibitors; Dacarbazine; Drug Administration Schedule; Female; Follow-Up Studies; Glioblastoma; Humans; Kaplan-Meier Estimate; Male; Neoplasm Grading; Retrospective Studies; Survival Analysis; Temozolomide; Treatment Outcome | 2015 |
Orthogonal targeting of EGFRvIII expressing glioblastomas through simultaneous EGFR and PLK1 inhibition.
Topics: Animals; Antineoplastic Agents, Alkylating; Blotting, Western; Brain Neoplasms; Cell Cycle Proteins; Cell Line, Tumor; Comet Assay; Dacarbazine; DNA Damage; ErbB Receptors; Flow Cytometry; Fluorescent Antibody Technique; Gene Knockout Techniques; Glioblastoma; Heterografts; Humans; Mice; Polo-Like Kinase 1; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; RNA, Small Interfering; Temozolomide | 2015 |
[A pleural transudate with a 0 g/L protein level].
Topics: Analgesics; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Brain Neoplasms; Catheters, Indwelling; Combined Modality Therapy; Cranial Irradiation; Dacarbazine; Diuretics; Drainage; Dyspnea; Exudates and Transudates; Fluid Therapy; Glioblastoma; Humans; Male; Methylene Blue; Middle Aged; Pleural Cavity; Pleural Effusion; Pneumothorax; Proteins; Radiography; Temozolomide | 2015 |
Photodynamic therapy in the treatment of brain tumours. A feasibility study.
Topics: Adolescent; Adult; Aged; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Dihematoporphyrin Ether; Feasibility Studies; Female; Humans; Male; Mesoporphyrins; Middle Aged; Neoplasm Recurrence, Local; Photochemotherapy; Photosensitizing Agents; Survival Analysis; Temozolomide; Young Adult | 2015 |
Brain Stem and Entire Spinal Leptomeningeal Dissemination of Supratentorial Glioblastoma Multiforme in a Patient during Postoperative Radiochemotherapy: Case Report and Review of the Literatures.
Topics: Adult; Antineoplastic Agents; Brain Neoplasms; Brain Stem Neoplasms; Chemoradiotherapy; Cisplatin; Dacarbazine; Glioblastoma; Humans; Magnetic Resonance Imaging; Male; Meningeal Neoplasms; Temozolomide | 2015 |
Hypercellularity Components of Glioblastoma Identified by High b-Value Diffusion-Weighted Imaging.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Edema; Brain Neoplasms; Chemoradiotherapy; Dacarbazine; Diffusion; Diffusion Magnetic Resonance Imaging; Disease-Free Survival; Female; Glioblastoma; Humans; Male; Middle Aged; Radiotherapy Dosage; Retrospective Studies; Temozolomide; Tumor Burden; Young Adult | 2015 |
The Synergistic Effect of Combination Progesterone and Temozolomide on Human Glioblastoma Cells.
Topics: Anti-Inflammatory Agents; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Brain Neoplasms; Cell Cycle; Cell Line, Tumor; Cell Movement; Cell Proliferation; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; Drug Synergism; ErbB Receptors; Glioblastoma; Humans; Phosphoinositide-3 Kinase Inhibitors; Progesterone; Proto-Oncogene Proteins c-akt; Signal Transduction; Temozolomide; TOR Serine-Threonine Kinases; Tumor Suppressor Proteins | 2015 |
Digital PCR quantification of MGMT methylation refines prediction of clinical benefit from alkylating agents in glioblastoma and metastatic colorectal cancer.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Colorectal Neoplasms; Dacarbazine; Disease-Free Survival; DNA; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Glioblastoma; Humans; Polymerase Chain Reaction; Prognosis; Promoter Regions, Genetic; Temozolomide; Tumor Suppressor Proteins | 2015 |
Management of glioblastoma in Victoria, Australia (2006-2008).
Topics: Aged; Antineoplastic Agents; Brain Neoplasms; Chemoradiotherapy; Cohort Studies; Dacarbazine; Female; Glioblastoma; Humans; Male; Middle Aged; Neurosurgical Procedures; Retrospective Studies; Temozolomide; Victoria | 2015 |
A Potential Role for the Inhibition of PI3K Signaling in Glioblastoma Therapy.
Topics: Antineoplastic Agents; Apoptosis; Brain Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Dacarbazine; Drug Synergism; Furans; Glioblastoma; Humans; Neoplasm Staging; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Pyridines; Pyrimidines; Signal Transduction; Temozolomide; TOR Serine-Threonine Kinases | 2015 |
Patients With Proneural Glioblastoma May Derive Overall Survival Benefit From the Addition of Bevacizumab to First-Line Radiotherapy and Temozolomide: Retrospective Analysis of the AVAglio Trial.
Topics: Adult; Aged; Angiogenesis Inhibitors; Antineoplastic Agents, Alkylating; Bevacizumab; Brain Neoplasms; Clinical Trials, Phase III as Topic; Dacarbazine; Disease-Free Survival; Female; Gene Expression Profiling; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Isocitrate Dehydrogenase; Kaplan-Meier Estimate; Male; Middle Aged; Mutation; Neoplasm Staging; Prognosis; Radiotherapy, Adjuvant; Randomized Controlled Trials as Topic; Retrospective Studies; Temozolomide; Treatment Outcome | 2015 |
Brain Exposure of Two Selective Dual CDK4 and CDK6 Inhibitors and the Antitumor Activity of CDK4 and CDK6 Inhibition in Combination with Temozolomide in an Intracranial Glioblastoma Xenograft.
Topics: Aminopyridines; Animals; Antineoplastic Combined Chemotherapy Protocols; Benzimidazoles; Brain; Brain Neoplasms; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase 6; Dacarbazine; Dogs; Female; Glioblastoma; Madin Darby Canine Kidney Cells; Male; Mice; Piperazines; Protein Kinase Inhibitors; Pyridines; Rats; Temozolomide; Xenograft Model Antitumor Assays | 2015 |
An image guided small animal radiation therapy platform (SmART) to monitor glioblastoma progression and therapy response.
Topics: Animals; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Line, Tumor; Chemoradiotherapy; Combined Modality Therapy; Dacarbazine; Disease Progression; Glioblastoma; Mice, SCID; Radiotherapy Dosage; Radiotherapy Planning, Computer-Assisted; Radiotherapy, Conformal; Radiotherapy, Image-Guided; Spheroids, Cellular; Temozolomide | 2015 |
PI3K pathway inhibition in GBM—is there a signal?
Topics: Antineoplastic Agents; Brain Neoplasms; Dacarbazine; Everolimus; Female; Glioblastoma; Gonanes; Humans; Male | 2015 |
[Exceptional metastasis of glioblastoma].
Topics: Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Glioblastoma; Humans; Male; Soft Tissue Neoplasms; Temozolomide | 2015 |
A new anti-glioma therapy, AG119: pre-clinical assessment in a mouse GL261 glioma model.
Topics: Angiogenesis Inhibitors; Animals; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; Disease Models, Animal; DNA Modification Methylases; DNA Repair Enzymes; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Glioma; Mice; Survival Analysis; Temozolomide; Tumor Suppressor Proteins | 2015 |
NVP-BEZ235, a novel dual PI3K-mTOR inhibitor displays anti-glioma activity and reduces chemoresistance to temozolomide in human glioma cells.
Topics: Animals; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; bcl-2-Associated X Protein; Brain Neoplasms; Caspase 3; Cell Line, Tumor; Cell Proliferation; Dacarbazine; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Drug Synergism; G1 Phase Cell Cycle Checkpoints; Glioma; Humans; Imidazoles; Inhibitory Concentration 50; Male; Mice, SCID; Phosphatidylinositol 3-Kinase; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Quinolines; Signal Transduction; Temozolomide; TOR Serine-Threonine Kinases; Tumor Burden; Xenograft Model Antitumor Assays | 2015 |
Liposome encapsulated of temozolomide for the treatment of glioma tumor: preparation, characterization and evaluation.
Topics: Animals; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Female; Glioma; Liposomes; Male; Mice; Rabbits; Solubility; Temozolomide; Tissue Distribution | 2015 |
Neuro-oncology: What is the optimal use of bevacizumab in glioblastoma?
Topics: Angiogenesis Inhibitors; Antibodies, Monoclonal, Humanized; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Chemoradiotherapy; Dacarbazine; Drug Costs; Female; Glioblastoma; Humans; Male; Quality of Life | 2015 |
Can We Predict Bevacizumab Responders in Patients With Glioblastoma?
Topics: Angiogenesis Inhibitors; Antineoplastic Agents, Alkylating; Bevacizumab; Brain Neoplasms; Dacarbazine; Female; Glioblastoma; Humans; Male | 2015 |
Novel RGD containing, temozolomide-loading nanostructured lipid carriers for glioblastoma multiforme chemotherapy.
Topics: Animals; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; Drug Carriers; Drug Liberation; Glioblastoma; Glioma; Lipids; Mice; Nanostructures; Phosphatidylethanolamines; Polyethylene Glycols; Temozolomide; Xenograft Model Antitumor Assays | 2016 |
Temozolomide competes for P-glycoprotein and contributes to chemoresistance in glioblastoma cells.
Topics: Animals; Antineoplastic Agents, Alkylating; ATP Binding Cassette Transporter, Subfamily B; Binding, Competitive; Brain Neoplasms; Caspase 3; Cell Line, Tumor; Cricetinae; Dacarbazine; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Fluoresceins; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Temozolomide; Transcription, Genetic; Transcriptional Activation; Transfection; Up-Regulation | 2015 |
Comment: Chemoradiotherapy for glioblastoma patients--the double-edged sword.
Topics: Antineoplastic Agents, Alkylating; Brain; Brain Neoplasms; Cranial Irradiation; Dacarbazine; Glioblastoma; Humans; Male | 2015 |
Microenvironmental Modulation of Decorin and Lumican in Temozolomide-Resistant Glioblastoma and Neuroblastoma Cancer Stem-Like Cells.
Topics: Brain Neoplasms; Chondroitin Sulfate Proteoglycans; Dacarbazine; Decorin; Glioblastoma; Humans; Keratan Sulfate; Lumican; Neoplastic Stem Cells; Neuroblastoma; Temozolomide; Tumor Microenvironment | 2015 |
Induction of microRNA-146a is involved in curcumin-mediated enhancement of temozolomide cytotoxicity against human glioblastoma.
Topics: Antineoplastic Agents; Apoptosis; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Curcumin; Dacarbazine; Drug Resistance, Neoplasm; Drug Synergism; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; MicroRNAs; NF-kappa B; Signal Transduction; Temozolomide | 2015 |
MGMT inactivation and clinical response in newly diagnosed GBM patients treated with Gliadel.
Topics: Aged; Aged, 80 and over; Brain Neoplasms; Carmustine; Chemoradiotherapy; Dacarbazine; Decanoic Acids; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Female; Glioblastoma; Humans; Japan; Karnofsky Performance Status; Male; Middle Aged; Polyesters; Prognosis; Promoter Regions, Genetic; Temozolomide; Tumor Suppressor Proteins | 2015 |
miR-144-3p exerts anti-tumor effects in glioblastoma by targeting c-Met.
Topics: 3' Untranslated Regions; Animals; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Apoptosis; Brain Neoplasms; Cell Line, Tumor; Cell Survival; Dacarbazine; Glioblastoma; Humans; Mice; Mice, Nude; MicroRNAs; Proto-Oncogene Proteins c-met; PTEN Phosphohydrolase; Radiation-Sensitizing Agents; Survival Analysis; Temozolomide | 2015 |
Dynamic contrast enhanced T1 MRI perfusion differentiates pseudoprogression from recurrent glioblastoma.
Topics: Adult; Aged; Aged, 80 and over; Alkaloids; Antineoplastic Agents, Alkylating; Brain Neoplasms; Contrast Media; Dacarbazine; Diffusion Magnetic Resonance Imaging; Disease Progression; Female; Glioblastoma; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Middle Aged; Neoplasm Recurrence, Local; Retrospective Studies; ROC Curve; Temozolomide; Time Factors; Treatment Outcome | 2015 |
Radiation as a foundation for glioblastoma therapy in elderly patients. In Regard to Arvold et al.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Female; Glioblastoma; Humans; Male | 2015 |
In Reply to Levra et al.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Female; Glioblastoma; Humans; Male | 2015 |
Independent Poor Prognostic Factors for True Progression after Radiation Therapy and Concomitant Temozolomide in Patients with Glioblastoma: Subependymal Enhancement and Low ADC Value.
Topics: Adult; Aged; Aged, 80 and over; Brain Neoplasms; Chemoradiotherapy; Cranial Irradiation; Dacarbazine; Diffusion Magnetic Resonance Imaging; Disease Progression; Ependyma; Female; Glioblastoma; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Prognosis; Sensitivity and Specificity; Temozolomide; Young Adult | 2015 |
Temozolomide Treatment for Pediatric Refractory Anaplastic Ependymoma with Low MGMT Protein Expression.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Child, Preschool; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; Ependymoma; Female; Humans; Immunohistochemistry; Infant; Male; Temozolomide; Tumor Suppressor Proteins | 2016 |
A New Epigenetic Mechanism of Temozolomide Action in Glioma Cells.
Topics: 5-Methylcytosine; Animals; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; DNA; DNA Methylation; Epigenesis, Genetic; Glioma; HeLa Cells; Humans; Oxidative Stress; Rats; Temozolomide | 2015 |
Diagnosis and Management of Spinal Metastasis of Glioblastoma.
Topics: Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Brain Neoplasms; Chemoradiotherapy; Dacarbazine; Glioblastoma; Humans; Male; Middle Aged; Positron-Emission Tomography; Spinal Neoplasms; Temozolomide | 2015 |
Investigating a signature of temozolomide resistance in GBM cell lines using metabolomics.
Topics: Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Electrophoresis, Gel, Two-Dimensional; Glioblastoma; Humans; Magnetic Resonance Spectroscopy; Metabolomics; Purines; Temozolomide; Tritium; Tumor Suppressor Proteins | 2015 |
[A Case of Advanced Malignant Melanoma of the Esophagus with Distant Metastases].
Topics: Aged; Antineoplastic Agents, Alkylating; Bone Neoplasms; Brain Neoplasms; Dacarbazine; Esophageal Neoplasms; Fatal Outcome; Female; Humans; Lymphatic Metastasis; Melanoma; Positron-Emission Tomography; Tomography, X-Ray Computed | 2015 |
Temozolomide as salvage treatment for recurrent intracranial ependymomas of the adult: a retrospective study.
Topics: Adolescent; Adult; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Ependymoma; Female; Follow-Up Studies; Humans; Male; Middle Aged; Neoplasm Grading; Neoplasm Recurrence, Local; Prognosis; Retrospective Studies; Salvage Therapy; Survival Rate; Temozolomide; Young Adult | 2016 |
Encapsulation of temozolomide in a tumor-targeting nanocomplex enhances anti-cancer efficacy and reduces toxicity in a mouse model of glioblastoma.
Topics: Animals; Antineoplastic Agents; Apoptosis; Brain Neoplasms; Cell Line, Tumor; Cell Survival; Dacarbazine; Female; Glioblastoma; Humans; Mice, Nude; Nanocapsules; Temozolomide; Treatment Outcome; Tumor Burden; Xenograft Model Antitumor Assays | 2015 |
BC3EE2,9B, a synthetic carbazole derivative, upregulates autophagy and synergistically sensitizes human GBM8901 glioblastoma cells to temozolomide.
Topics: Antineoplastic Agents; Autophagy; Brain Neoplasms; Carbazoles; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Movement; Cell Proliferation; Dacarbazine; Drug Resistance, Neoplasm; Drug Synergism; G1 Phase; Glioblastoma; Humans; Neoplasm Invasiveness; Proto-Oncogene Proteins c-akt; Signal Transduction; Temozolomide; Up-Regulation | 2015 |
Metformin influences progression in diabetic glioblastoma patients.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Blood Glucose; Brain; Brain Neoplasms; Chemoradiotherapy; Combined Modality Therapy; Dacarbazine; Diabetes Complications; Disease Progression; Disease-Free Survival; Female; Follow-Up Studies; Glioblastoma; Humans; Hyperglycemia; Hypoglycemic Agents; Magnetic Resonance Imaging; Male; Metformin; Middle Aged; Retrospective Studies; Temozolomide; Young Adult | 2015 |
Interferon-α/β enhances temozolomide activity against MGMT-positive glioma stem-like cells.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; Drug Synergism; Gene Expression Regulation, Neoplastic; Glioma; Humans; Interferon Type I; Male; Mice; Neoplastic Stem Cells; Temozolomide; Tumor Suppressor Proteins; Xenograft Model Antitumor Assays | 2015 |
Inhibition of DNA-repair genes Ercc1 and Mgmt enhances temozolomide efficacy in gliomas treatment: a pre-clinical study.
Topics: Animals; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Death; Cell Line, Tumor; Cell Proliferation; Cisplatin; Dacarbazine; DNA Modification Methylases; DNA Repair; DNA Repair Enzymes; DNA-Binding Proteins; Drug Resistance, Neoplasm; Endonucleases; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Glioma; Humans; Mice, Nude; RNA Interference; RNAi Therapeutics; Temozolomide; Time Factors; Transfection; Tumor Burden; Tumor Suppressor Proteins; Xenograft Model Antitumor Assays | 2015 |
DNMT1 mediates chemosensitivity by reducing methylation of miRNA-20a promoter in glioma cells.
Topics: Animals; Antineoplastic Agents, Alkylating; Apoptosis; Brain; Brain Neoplasms; Dacarbazine; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Drug Resistance, Neoplasm; Female; Gene Expression Regulation, Neoplastic; Glioma; Humans; Mice, Inbred C57BL; MicroRNAs; Promoter Regions, Genetic; Temozolomide | 2015 |
Spatiotemporal Evolution of the Primary Glioblastoma Genome.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Glioblastoma; Glioma; Humans; Isocitrate Dehydrogenase; Middle Aged; Neoplasm Recurrence, Local; Temozolomide | 2015 |
Withholding temozolomide in glioblastoma patients with unmethylated MGMT promoter--still a dilemma?
Topics: Antineoplastic Agents; Brain Neoplasms; Dacarbazine; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Glioblastoma; Humans; Promoter Regions, Genetic; Temozolomide; Tumor Suppressor Proteins | 2015 |
Combined Delivery of Temozolomide and Anti-miR221 PNA Using Mesoporous Silica Nanoparticles Induces Apoptosis in Resistant Glioma Cells.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; Drug Combinations; Drug Delivery Systems; Drug Resistance, Neoplasm; Glioma; Humans; MicroRNAs; Nanoparticles; Peptide Nucleic Acids; Peptides; Porosity; Rats; Silicon Dioxide; Temozolomide | 2015 |
Afatinib, an irreversible ErbB family blocker, with protracted temozolomide in recurrent glioblastoma: a case report.
Topics: Afatinib; Brain Neoplasms; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Combined Modality Therapy; Dacarbazine; ErbB Receptors; Female; Genotype; Glioblastoma; High-Throughput Nucleotide Sequencing; Humans; Middle Aged; Mutation; Neoplasm Recurrence, Local; Oncogene Proteins v-erbB; Quinazolines; Radiation-Sensitizing Agents; Temozolomide; Treatment Outcome | 2015 |
Predictors of survival and effect of short (40 Gy) or standard-course (60 Gy) irradiation plus concomitant temozolomide in elderly patients with glioblastoma: a multicenter retrospective study of AINO (Italian Association of Neuro-Oncology).
Topics: Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemoradiotherapy; Combined Modality Therapy; Dacarbazine; Disease-Free Survival; DNA Methylation; Female; Glioblastoma; Humans; Isocitrate Dehydrogenase; Italy; Karnofsky Performance Status; Magnetic Resonance Imaging; Male; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Radiotherapy Dosage; Retrospective Studies; Temozolomide | 2015 |
A stapled peptide antagonist of MDM2 carried by polymeric micelles sensitizes glioblastoma to temozolomide treatment through p53 activation.
Topics: Animals; Antineoplastic Agents, Alkylating; Apoptosis; Brain Neoplasms; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Dacarbazine; Glioblastoma; Humans; Male; Mice, Inbred BALB C; Mice, Nude; Micelles; Peptides, Cyclic; Polyethylene Glycols; Proto-Oncogene Proteins c-mdm2; Temozolomide; Tumor Burden; Tumor Suppressor Protein p53 | 2015 |
Metformin and temozolomide act synergistically to inhibit growth of glioma cells and glioma stem cells in vitro and in vivo.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Dacarbazine; Drug Synergism; Glioblastoma; Humans; Male; Metformin; Mice; Mice, SCID; Neoplastic Stem Cells; Random Allocation; Signal Transduction; Temozolomide; Xenograft Model Antitumor Assays | 2015 |
Pediatric gliosarcoma treated with adjuvant radiotherapy and temozolomide.
Topics: Adolescent; Antineoplastic Agents, Alkylating; Brain Neoplasms; Child; Combined Modality Therapy; Dacarbazine; Female; Follow-Up Studies; Gliosarcoma; Humans; Male; Retrospective Studies; Survival Analysis; Survival Rate; Temozolomide; Young Adult | 2015 |
Timing of Adjuvant Radiotherapy in Glioblastoma Patients: A Single-Institution Experience With More Than 400 Patients.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Biomarkers; Biopsy; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Female; Glioblastoma; Humans; Karnofsky Performance Status; Male; Middle Aged; Neurosurgical Procedures; Radiotherapy, Adjuvant; Retrospective Studies; Survival Analysis; Temozolomide; Treatment Outcome | 2016 |
The radiosensitivity index predicts for overall survival in glioblastoma.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemoradiotherapy; Dacarbazine; Female; Glioblastoma; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Proportional Hazards Models; Radiation Tolerance; Temozolomide; Transcriptome; Treatment Outcome | 2015 |
Glioblastoma in the elderly: the effect of aggressive and modern therapies on survival.
Topics: Aged; Aged, 80 and over; Aging; Antineoplastic Agents, Alkylating; Antineoplastic Agents, Phytogenic; Bevacizumab; Brain Neoplasms; Camptothecin; Cohort Studies; Combined Modality Therapy; Dacarbazine; Female; Glioblastoma; Humans; Irinotecan; Kaplan-Meier Estimate; Karnofsky Performance Status; Male; Neurosurgical Procedures; Prognosis; Survival Analysis; Temozolomide | 2016 |
Combination of temozolomide and Taxol exerts a synergistic inhibitory effect on Taxol‑resistant glioma cells via inhibition of glucose metabolism.
Topics: Antineoplastic Agents; Brain; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; Drug Resistance, Neoplasm; Drug Synergism; Glioma; Glucose; Humans; Paclitaxel; Temozolomide | 2015 |
Clinical, Radiographic, and Pathologic Findings in Patients Undergoing Reoperation Following Radiation Therapy and Temozolomide for Newly Diagnosed Glioblastoma.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemoradiotherapy; Craniotomy; Dacarbazine; Female; Glioblastoma; Humans; Karnofsky Performance Status; Magnetic Resonance Imaging; Male; Middle Aged; Neoplasm Recurrence, Local; Reoperation; Retrospective Studies; Survival Rate; Temozolomide | 2017 |
Resveratrol sensitizes glioblastoma-initiating cells to temozolomide by inducing cell apoptosis and promoting differentiation.
Topics: Apoptosis; Ataxia Telangiectasia Mutated Proteins; Brain Neoplasms; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Dacarbazine; Drug Synergism; Female; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Neoplastic Stem Cells; Phosphorylation; Resveratrol; Signal Transduction; Stilbenes; Temozolomide; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2016 |
IDH mutation and MGMT promoter methylation in glioblastoma: results of a prospective registry.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Biomarkers, Tumor; Brain Neoplasms; Chemoradiotherapy; Dacarbazine; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Female; Follow-Up Studies; Glioblastoma; Humans; Immunoenzyme Techniques; Isocitrate Dehydrogenase; Male; Middle Aged; Mutation; Neoplasm Staging; Prognosis; Promoter Regions, Genetic; Prospective Studies; Registries; Survival Rate; Temozolomide; Tumor Suppressor Proteins; Young Adult | 2015 |
Dexamethasone administration during definitive radiation and temozolomide renders a poor prognosis in a retrospective analysis of newly diagnosed glioblastoma patients.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Brain Neoplasms; Chemoradiotherapy; Dacarbazine; Dexamethasone; Disease-Free Survival; Female; Glioblastoma; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Prognosis; Proportional Hazards Models; Retrospective Studies; Temozolomide | 2015 |
Determination of an optimal dosing schedule for combining Irinophore C™ and temozolomide in an orthotopic model of glioblastoma.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Brain Neoplasms; Camptothecin; Dacarbazine; Drug Administration Schedule; Drug Compounding; Glioblastoma; Humans; Irinotecan; Liposomes; Mice, Inbred NOD; Mice, SCID; Neovascularization, Pathologic; Temozolomide; Time Factors; Tumor Burden; Xenograft Model Antitumor Assays | 2015 |
Temozolomide reverses doxorubicin resistance by inhibiting P-glycoprotein in malignant glioma cells.
Topics: Adenosine Triphosphatases; Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; Doxorubicin; Drug Resistance, Neoplasm; Drug Therapy, Combination; Glioma; Humans; Rats; Survival Analysis; Temozolomide | 2016 |
In Regard to Arvold et al.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Female; Glioblastoma; Humans; Male | 2015 |
Validation of the Effectiveness and Safety of Temozolomide during and after Radiotherapy for Newly Diagnosed Glioblastomas: 10-year Experience of a Single Institution.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemoradiotherapy, Adjuvant; Comorbidity; Dacarbazine; Female; Glioblastoma; Hematologic Diseases; Humans; Longitudinal Studies; Male; Middle Aged; Prevalence; Radiotherapy, Conformal; Republic of Korea; Risk Factors; Survival Rate; Temozolomide; Treatment Outcome; Young Adult | 2015 |
Nucleolin antagonist triggers autophagic cell death in human glioblastoma primary cells and decreased in vivo tumor growth in orthotopic brain tumor model.
Topics: Adult; Aged; Animals; Antineoplastic Agents, Alkylating; Autophagy; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dacarbazine; Drug Synergism; Female; G1 Phase Cell Cycle Checkpoints; Glioblastoma; Humans; Kaplan-Meier Estimate; Mice, Inbred BALB C; Mice, Nude; Microscopy, Fluorescence; Middle Aged; Nucleolin; Peptides; Phosphoproteins; RNA-Binding Proteins; Temozolomide; Tumor Burden; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2015 |
Connexin 43 Inhibition Sensitizes Chemoresistant Glioblastoma Cells to Temozolomide.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Biomimetic Materials; Brain Neoplasms; Cell Line, Tumor; Connexin 43; Dacarbazine; Drug Synergism; Glioblastoma; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Peptides; Signal Transduction; Temozolomide; Xenograft Model Antitumor Assays | 2016 |
Seizure reduction is a prognostic marker in low-grade glioma patients treated with temozolomide.
Topics: Adult; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Disease-Free Survival; Female; Glioma; Humans; Male; Middle Aged; Retrospective Studies; Seizures; Temozolomide; Treatment Outcome | 2016 |
Nanoparticle-Delivered Antisense MicroRNA-21 Enhances the Effects of Temozolomide on Glioblastoma Cells.
Topics: Antineoplastic Agents, Alkylating; Antisense Elements (Genetics); Brain Neoplasms; Caspase 3; Cell Line, Tumor; Dacarbazine; Gene Expression Regulation, Neoplastic; Glioblastoma; Glioma; Humans; MicroRNAs; Nanoparticles; PTEN Phosphohydrolase; Temozolomide | 2015 |
[Survival benefit from the addition of bevacizumab to first-line radiochemotherapy for the treatment of proneural glioblastoma?].
Topics: Angiogenesis Inhibitors; Antineoplastic Agents, Alkylating; Bevacizumab; Brain Neoplasms; Dacarbazine; Female; Glioblastoma; Humans; Male | 2016 |
The histone demethylase KDM5A is a key factor for the resistance to temozolomide in glioblastoma.
Topics: Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Brain Neoplasms; Cell Cycle; Cell Differentiation; Cell Line, Tumor; Cell Shape; Dacarbazine; DNA Methylation; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Drug Synergism; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Genotype; Glioblastoma; Histone Deacetylase Inhibitors; Humans; Neoplastic Stem Cells; Phenotype; Retinoblastoma-Binding Protein 2; RNA Interference; Temozolomide; Time Factors; Transfection | 2015 |
Anti-tumor activities of luteolin and silibinin in glioblastoma cells: overexpression of miR-7-1-3p augmented luteolin and silibinin to inhibit autophagy and induce apoptosis in glioblastoma in vivo.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Autophagy; Brain Neoplasms; Carmustine; Caspase 8; Cell Line, Tumor; Cell Movement; Cell Proliferation; Dacarbazine; Female; Glioblastoma; Humans; Luteolin; Mice; Mice, Nude; MicroRNAs; Signal Transduction; Silybin; Silymarin; Sirolimus; Temozolomide; Xenograft Model Antitumor Assays | 2016 |
Amino acid positron emission tomography to monitor chemotherapy response and predict seizure control and progression-free survival in WHO grade II gliomas.
Topics: Adult; Amino Acids; Antineoplastic Agents; Area Under Curve; Brain Neoplasms; Dacarbazine; Disease-Free Survival; Female; Glioma; Humans; Image Interpretation, Computer-Assisted; Magnetic Resonance Imaging; Male; Middle Aged; Neoplasm Grading; Positron-Emission Tomography; ROC Curve; Seizures; Sensitivity and Specificity; Temozolomide; Young Adult | 2016 |
Topological robustness analysis of protein interaction networks reveals key targets for overcoming chemotherapy resistance in glioma.
Topics: Brain Neoplasms; Cell Line, Tumor; Cell Survival; Dacarbazine; Drug Resistance, Neoplasm; Gene Knockdown Techniques; Glioma; Humans; Protein Interaction Maps; Signal Transduction; Survival Analysis; Temozolomide | 2015 |
Evolving management of low grade glioma: No consensus amongst treating clinicians.
Topics: Adult; Australia; Brain Neoplasms; Cohort Studies; Consensus; Dacarbazine; Disease Management; Female; Glioma; Humans; Male; Middle Aged; Neoplasm Grading; Physicians; Surveys and Questionnaires; Temozolomide | 2016 |
Wnt/β-catenin pathway regulates MGMT gene expression in cancer and inhibition of Wnt signalling prevents chemoresistance.
Topics: Animals; Antineoplastic Agents; Benzeneacetamides; beta Catenin; Brain Neoplasms; Camptothecin; Celecoxib; Cisplatin; Colorectal Neoplasms; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; Doxorubicin; Drug Resistance, Neoplasm; Flow Cytometry; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Glioma; Glucose-6-Phosphate Isomerase; Heterocyclic Compounds, 3-Ring; Humans; Immunoblotting; Immunohistochemistry; Irinotecan; Medulloblastoma; Mice; Neoplasm Transplantation; Neoplasms; Neuroblastoma; Pyrans; Pyrazines; Pyridines; Real-Time Polymerase Chain Reaction; Sulfones; Temozolomide; Triazoles; Tumor Suppressor Proteins; Vincristine; Wnt Proteins; Wnt Signaling Pathway | 2015 |
Antitumor action of temozolomide, ritonavir and aprepitant against human glioma cells.
Topics: Antiemetics; Antineoplastic Agents, Alkylating; Apoptosis; Aprepitant; Brain Neoplasms; Cell Proliferation; Dacarbazine; Glioblastoma; HIV Protease Inhibitors; Humans; Immunoenzyme Techniques; Morpholines; Ritonavir; Temozolomide; Tumor Cells, Cultured | 2016 |
Glioblastomas with IDH1/2 mutations have a short clinical history and have a favorable clinical outcome.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Chemoradiotherapy; Chromosome Deletion; Chromosomes, Human, Pair 1; Dacarbazine; DNA Methylation; Female; Glioblastoma; Guanine; Humans; Isocitrate Dehydrogenase; Japan; Kaplan-Meier Estimate; Karnofsky Performance Status; Male; Middle Aged; Mutation; Predictive Value of Tests; Prognosis; Promoter Regions, Genetic; Temozolomide | 2016 |
Reply to M.C. Chamberlain.
Topics: Angiogenesis Inhibitors; Antibodies, Monoclonal, Humanized; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemoradiotherapy; Dacarbazine; Female; Glioblastoma; Humans; Male; Quality of Life | 2016 |
Similar Trials With Differing Outcomes: Reconciliation in Glioblastoma.
Topics: Angiogenesis Inhibitors; Antibodies, Monoclonal, Humanized; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemoradiotherapy; Dacarbazine; Female; Glioblastoma; Humans; Male; Quality of Life | 2016 |
Co-expression of Cytoskeletal Protein Adducin 3 and CD133 in Neurospheres and a Temozolomide-resistant Subclone of Glioblastoma.
Topics: AC133 Antigen; Antigens, CD; Antineoplastic Agents, Alkylating; Apoptosis; Brain Neoplasms; Calmodulin-Binding Proteins; Cell Line, Tumor; Dacarbazine; Glioblastoma; Glycoproteins; Humans; Neoplastic Stem Cells; Peptides; Temozolomide | 2015 |
SRPX2 Enhances the Epithelial-Mesenchymal Transition and Temozolomide Resistance in Glioblastoma Cells.
Topics: Brain Neoplasms; Cell Line, Tumor; Cell Movement; Dacarbazine; Drug Resistance, Neoplasm; Epithelial-Mesenchymal Transition; Glioblastoma; Humans; Membrane Proteins; Neoplasm Invasiveness; Neoplasm Proteins; Nerve Tissue Proteins; Prognosis; RNA Interference; Temozolomide | 2016 |
Sulforaphane reverses chemo-resistance to temozolomide in glioblastoma cells by NF-κB-dependent pathway downregulating MGMT expression.
Topics: Animals; Apoptosis; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; Down-Regulation; Drug Resistance, Neoplasm; Female; Gene Expression; Glioblastoma; Humans; Isothiocyanates; Mice; Mice, Nude; NF-kappa B; Signal Transduction; Sulfoxides; Temozolomide; Tumor Suppressor Proteins; Xenograft Model Antitumor Assays | 2016 |
Patient-derived glioblastoma cells show significant heterogeneity in treatment responses to the inhibitor-of-apoptosis-protein antagonist birinapant.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Blotting, Western; Brain Neoplasms; Caspase 8; Cell Line, Tumor; Cell Survival; Dacarbazine; Dipeptides; Drug Resistance, Neoplasm; Flow Cytometry; Glioblastoma; Humans; In Vitro Techniques; Indoles; Inhibitor of Apoptosis Proteins; Mice; Mice, Inbred NOD; Mice, SCID; Microscopy, Phase-Contrast; Neoplasm Transplantation; Temozolomide; Xenograft Model Antitumor Assays | 2016 |
Alternating Electric Fields for the Treatment of Glioblastoma.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Electric Stimulation Therapy; Female; Glioblastoma; Humans; Maintenance Chemotherapy; Male | 2015 |
Multiple resections and survival of recurrent glioblastoma patients in the temozolomide era.
Topics: Adult; Aged; Antineoplastic Agents; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Female; Glioblastoma; Humans; Kaplan-Meier Estimate; Karnofsky Performance Status; Male; Middle Aged; Multivariate Analysis; Neoplasm Recurrence, Local; Neurosurgical Procedures; Proportional Hazards Models; Radiotherapy, Adjuvant; Retrospective Studies; Risk Factors; Temozolomide | 2016 |
A versatile ex vivo technique for assaying tumor angiogenesis and microglia in the brain.
Topics: Animals; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Dacarbazine; Glioma; Green Fluorescent Proteins; Humans; Mice, Transgenic; Microglia; Microscopy, Confocal; Microscopy, Fluorescence; Neovascularization, Pathologic; Organ Culture Techniques; Rats, Wistar; Reproducibility of Results; Temozolomide; Tumor Microenvironment | 2016 |
High-grade glioma in children and adolescents: a single-center experience.
Topics: Adolescent; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Child; Combined Modality Therapy; Dacarbazine; Disease-Free Survival; Female; Glioblastoma; Humans; Karnofsky Performance Status; Lomustine; Male; Neurosurgical Procedures; Procarbazine; Prognosis; Proportional Hazards Models; Radiotherapy; Retrospective Studies; Survival Rate; Temozolomide; Vincristine | 2016 |
Immunohistochemical analysis of O6-methylguanine-DNA methyltransferase (MGMT) protein expression as prognostic marker in glioblastoma patients treated with radiation therapy with concomitant and adjuvant Temozolomide.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Biomarkers, Tumor; Brain Neoplasms; Chemotherapy, Adjuvant; Combined Modality Therapy; Dacarbazine; Female; Gene Expression; Glioblastoma; Humans; Immunohistochemistry; Kaplan-Meier Estimate; Male; Middle Aged; O(6)-Methylguanine-DNA Methyltransferase; Prognosis; Radiotherapy, Adjuvant; Temozolomide; Treatment Outcome | 2016 |
A novel drug conjugate, NEO212, targeting proneural and mesenchymal subtypes of patient-derived glioma cancer stem cells.
Topics: Animals; Antineoplastic Agents, Alkylating; Apoptosis; Biomarkers, Tumor; Brain Neoplasms; Dacarbazine; DNA Breaks, Double-Stranded; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Glioma; Humans; Male; Mesenchymal Stem Cells; Mice, Inbred NOD; Mice, SCID; Neoplasm Invasiveness; Neoplastic Stem Cells; Neural Stem Cells; Temozolomide; Time Factors; Tumor Burden; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2016 |
EpiBrainRad: an epidemiologic study of the neurotoxicity induced by radiotherapy in high grade glioma patients.
Topics: Adult; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemotherapy, Adjuvant; Cognition Disorders; Dacarbazine; Early Diagnosis; Female; Follow-Up Studies; Glioma; Humans; Leukoencephalopathies; Male; Prospective Studies; Radiotherapy; Temozolomide | 2015 |
Intra-arterial administration improves temozolomide delivery and efficacy in a model of intracerebral metastasis, but has unexpected brain toxicity.
Topics: Animals; Antineoplastic Agents, Alkylating; Blood-Brain Barrier; Brain Neoplasms; Dacarbazine; Drug Delivery Systems; Humans; Injections, Intra-Arterial; Lung Neoplasms; Male; Middle Aged; Neurotoxicity Syndromes; Rats; Rats, Nude; Small Cell Lung Carcinoma; Temozolomide; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2016 |
High levels of apoptosis are induced in human glioma cell lines by co-administration of peptide nucleic acids targeting miR-221 and miR-222.
Topics: Apoptosis; Brain Neoplasms; Cell Line, Tumor; Cell Survival; Dacarbazine; Drug Resistance, Neoplasm; Glioma; Humans; MicroRNAs; Peptide Nucleic Acids; Phenotype; Surface Plasmon Resonance; Temozolomide | 2016 |
Double Blockade of Glioma Cell Proliferation and Migration by Temozolomide Conjugated with NPPB, a Chloride Channel Blocker.
Topics: Antineoplastic Agents; Apoptosis; Brain Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Chloride Channels; Comet Assay; Dacarbazine; Flow Cytometry; Glioma; Humans; Nitrobenzoates; Patch-Clamp Techniques; Temozolomide | 2016 |
Plasmid pORF-hTRAIL targeting to glioma using transferrin-modified polyamidoamine dendrimer.
Topics: Animals; Apoptosis; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; Dendrimers; Gene Expression Regulation; Gene Transfer Techniques; Genetic Therapy; Glioma; Green Fluorescent Proteins; Magnetic Resonance Imaging; Male; Nanoparticles; Open Reading Frames; Plasmids; Polyethylene Glycols; Rats; Rats, Sprague-Dawley; Survival Rate; Temozolomide; Transferrin | 2016 |
In Vitro Validation of Intratumoral Modulation Therapy for Glioblastoma.
Topics: Antineoplastic Agents, Alkylating; Apoptosis; Brain Neoplasms; Cell Line, Tumor; Cell Survival; Chemotherapy, Adjuvant; Dacarbazine; Electric Stimulation Therapy; Gene Expression Regulation, Neoplastic; Gene Silencing; Glioblastoma; Heat-Shock Proteins; HSP27 Heat-Shock Proteins; Humans; Molecular Chaperones; RNA Interference; RNAi Therapeutics; Temozolomide; Transfection; Tumor Cells, Cultured | 2016 |
MiR-16 modulate temozolomide resistance by regulating BCL-2 in human glioma cells.
Topics: Antineoplastic Agents, Alkylating; Apoptosis; Blotting, Western; Brain Neoplasms; Cell Line, Tumor; Cell Survival; Dacarbazine; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Glioma; Humans; MicroRNAs; Polymerase Chain Reaction; Proto-Oncogene Proteins c-bcl-2; RNA, Small Interfering; Temozolomide; Transfection | 2015 |
Association between treatment-related lymphopenia and overall survival in elderly patients with newly diagnosed glioblastoma.
Topics: Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemoradiotherapy; Dacarbazine; Female; Follow-Up Studies; Glioblastoma; Humans; Lymphopenia; Male; Neoplasm Grading; Prognosis; Radiotherapy Dosage; Retrospective Studies; Survival Rate; Temozolomide | 2016 |
Current trends in the management of glioblastoma in a French University Hospital and associated direct costs.
Topics: Aged; Antineoplastic Agents; Bevacizumab; Brain Neoplasms; Chemoradiotherapy; Dacarbazine; Drug Costs; Female; Follow-Up Studies; France; Glioblastoma; Health Care Costs; Hospitalization; Hospitals, University; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Survival Rate; Temozolomide | 2016 |
Singapore Cancer Network (SCAN) Guidelines for Systemic Therapy of High-Grade Glioma.
Topics: Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Bevacizumab; Brain Neoplasms; Camptothecin; Carboplatin; Chemoradiotherapy; Chemotherapy, Adjuvant; Chromosomes, Human, Pair 1; Chromosomes, Human, Pair 19; Cyclophosphamide; Dacarbazine; Glioblastoma; Humans; Irinotecan; Lomustine; Neoplasm Grading; Neoplasm Recurrence, Local; Oligodendroglioma; Procarbazine; Radiotherapy; Singapore; Temozolomide; Teniposide; Vincristine | 2015 |
SGEF Is Regulated via TWEAK/Fn14/NF-κB Signaling and Promotes Survival by Modulation of the DNA Repair Response to Temozolomide.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Line, Tumor; Cell Survival; Cytokine TWEAK; Dacarbazine; DNA Repair; Drug Resistance, Neoplasm; Glioblastoma; Guanine Nucleotide Exchange Factors; Humans; NF-kappa B; Receptors, Tumor Necrosis Factor; Signal Transduction; Temozolomide; Tumor Necrosis Factors; TWEAK Receptor; Up-Regulation | 2016 |
Nimotuzumab enhances temozolomide-induced growth suppression of glioma cells expressing mutant EGFR in vivo.
Topics: Animals; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dacarbazine; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Drug Synergism; ErbB Receptors; Gene Expression Regulation, Neoplastic; Glioma; Humans; Mice; Mutation; Signal Transduction; Temozolomide; Tumor Suppressor Proteins; Xenograft Model Antitumor Assays | 2016 |
Involvement of DDX6 gene in radio- and chemoresistance in glioblastoma.
Topics: Animals; Brain Neoplasms; Cell Proliferation; Cell Survival; Dacarbazine; DEAD-box RNA Helicases; Drug Resistance, Neoplasm; Gene Library; Genome; Glioblastoma; HEK293 Cells; Humans; Male; Mice; Mice, Nude; Neoplasm Transplantation; Proto-Oncogene Proteins; RNA, Small Interfering; Temozolomide; Up-Regulation | 2016 |
Does Valproic Acid or Levetiracetam Improve Survival in Glioblastoma? A Pooled Analysis of Prospective Clinical Trials in Newly Diagnosed Glioblastoma.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemoradiotherapy; Clinical Trials as Topic; Dacarbazine; Epilepsy; Female; Glioblastoma; Humans; Levetiracetam; Male; Middle Aged; Piracetam; Prognosis; Survival Analysis; Temozolomide; Valproic Acid | 2016 |
Core pathway mutations induce de-differentiation of murine astrocytes into glioblastoma stem cells that are sensitive to radiation but resistant to temozolomide.
Topics: Animals; Astrocytes; Brain Neoplasms; Cell Differentiation; Cell Line, Tumor; Dacarbazine; Drug Resistance, Neoplasm; Glioblastoma; Mice, Transgenic; Mutation; Neoplastic Stem Cells; Signal Transduction; Temozolomide | 2016 |
Prognostic factors and survival study in high-grade glioma in the elderly.
Topics: Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Female; Glioma; Humans; Male; Middle Aged; Neoplasm Grading; Neurosurgical Procedures; Prognosis; Survival Analysis; Temozolomide; Treatment Outcome | 2016 |
Metronomic Doses of Temozolomide Enhance the Efficacy of Carbon Nanotube CpG Immunotherapy in an Invasive Glioma Model.
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Cell Death; Cell Line, Tumor; Dacarbazine; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Glioma; Immunotherapy; Inflammation; Lipids; Mice, Inbred C57BL; Nanotubes, Carbon; Neoplasm Invasiveness; Oligodeoxyribonucleotides; Polyethylene Glycols; Spleen; Temozolomide; Treatment Outcome | 2016 |
Valproic acid, compared to other antiepileptic drugs, is associated with improved overall and progression-free survival in glioblastoma but worse outcome in grade II/III gliomas treated with temozolomide.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Antineoplastic Agents, Alkylating; Brain Neoplasms; Child; Dacarbazine; Drug Therapy, Combination; Female; Follow-Up Studies; Glioblastoma; Humans; Male; Middle Aged; Neoplasm Grading; Neoplasm Recurrence, Local; Prognosis; Retrospective Studies; Survival Rate; Temozolomide; Valproic Acid; Young Adult | 2016 |
Craniospinal irradiation with concomitant and adjuvant temozolomide--a feasibility assessment of toxicity in patients with glioblastoma with a PNET component.
Topics: Adolescent; Adult; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemoradiotherapy; Chemotherapy, Adjuvant; Child; Craniospinal Irradiation; Dacarbazine; Dose Fractionation, Radiation; Feasibility Studies; Female; Follow-Up Studies; Glioblastoma; Humans; Lymphopenia; Male; Neoplasm Staging; Neuroectodermal Tumors, Primitive; Neutropenia; Prognosis; Survival Rate; Temozolomide; Thrombocytopenia; Young Adult | 2016 |
Monoamine oxidase A (MAO A) inhibitors decrease glioma progression.
Topics: Animals; Antineoplastic Agents, Alkylating; Apoptosis; Brain Neoplasms; Cell Proliferation; Dacarbazine; Disease Progression; Drug Resistance, Neoplasm; Drug Synergism; Glioma; Humans; Male; Mice; Mice, Nude; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Temozolomide; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2016 |
Additive antiangiogenesis effect of ginsenoside Rg3 with low-dose metronomic temozolomide on rat glioma cells both in vivo and in vitro.
Topics: Administration, Metronomic; Angiogenesis Inhibitors; Animals; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Dacarbazine; Drug Synergism; Gene Expression Regulation, Neoplastic; Ginsenosides; Glioblastoma; Human Umbilical Vein Endothelial Cells; Humans; Rats; Temozolomide; Xenograft Model Antitumor Assays | 2016 |
mTOR inhibition decreases SOX2-SOX9 mediated glioma stem cell activity and temozolomide resistance.
Topics: Adult; Animals; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Glioblastoma; Glioma; Humans; Mice; Mice, Inbred NOD; Mice, Nude; Mice, SCID; Sirolimus; SOX9 Transcription Factor; SOXB1 Transcription Factors; Temozolomide; TOR Serine-Threonine Kinases; Xenograft Model Antitumor Assays | 2016 |
Non-thermal atmospheric plasma induces ROS-independent cell death in U373MG glioma cells and augments the cytotoxicity of temozolomide.
Topics: Antineoplastic Agents, Alkylating; Apoptosis; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; Drug Synergism; Glioma; HeLa Cells; Humans; Plasma Gases; Reactive Oxygen Species; Temozolomide | 2016 |
Assessment of Quantitative and Allelic MGMT Methylation Patterns as a Prognostic Marker in Glioblastoma.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chi-Square Distribution; Dacarbazine; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Female; Genetic Association Studies; Genotype; Glioblastoma; Humans; Male; Middle Aged; Polymorphism, Single Nucleotide; Promoter Regions, Genetic; Retrospective Studies; Survival Analysis; Temozolomide; Tumor Suppressor Proteins; Young Adult | 2016 |
MR Studies of Glioblastoma Models Treated with Dual PI3K/mTOR Inhibitor and Temozolomide:Metabolic Changes Are Associated with Enhanced Survival.
Topics: Animals; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; Disease Models, Animal; Female; Glioblastoma; Humans; Immunohistochemistry; Kaplan-Meier Estimate; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Mice; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Prognosis; Protein Kinase Inhibitors; Temozolomide; TOR Serine-Threonine Kinases; Xenograft Model Antitumor Assays | 2016 |
Identification of Patients Who Benefit From Bevacizumab in High-Grade Glioma-An Easy Question Turned Difficult: Treat the Scan or the Patient?
Topics: Angiogenesis Inhibitors; Antibodies, Monoclonal, Humanized; Antineoplastic Agents, Alkylating; Bevacizumab; Brain Neoplasms; Chemoradiotherapy; Dacarbazine; Female; Glioblastoma; Humans; Male; Quality of Life | 2016 |
Reply to T.J. Kruser et al.
Topics: Angiogenesis Inhibitors; Antibodies, Monoclonal, Humanized; Antineoplastic Agents, Alkylating; Bevacizumab; Brain Neoplasms; Chemoradiotherapy; Dacarbazine; Female; Glioblastoma; Humans; Male; Quality of Life | 2016 |
BIRC3 is a novel driver of therapeutic resistance in Glioblastoma.
Topics: Animals; Baculoviral IAP Repeat-Containing 3 Protein; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Inhibitor of Apoptosis Proteins; Mice; Neoplasm Recurrence, Local; Phosphatidylinositol 3-Kinases; Radiation Tolerance; Radiotherapy; STAT3 Transcription Factor; Survival Analysis; Temozolomide; Ubiquitin-Protein Ligases; Up-Regulation; Xenograft Model Antitumor Assays | 2016 |
Combination Therapy with AKT3 and PI3KCA siRNA Enhances the Antitumor Effect of Temozolomide and Carmustine in T98G Glioblastoma Multiforme Cells.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Autophagy; Brain Neoplasms; Carmustine; Cell Cycle; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Dacarbazine; Glioblastoma; Humans; Nuclear Proteins; Proto-Oncogene Proteins c-akt; RNA, Small Interfering; Signal Transduction; Temozolomide; Transcription Factors | 2016 |
SPOCK1 is upregulated in recurrent glioblastoma and contributes to metastasis and Temozolomide resistance.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Line, Tumor; Cell Movement; Dacarbazine; Drug Resistance, Neoplasm; Epithelial-Mesenchymal Transition; Glioblastoma; Humans; Neoplasm Invasiveness; Neoplasm Recurrence, Local; Proteoglycans; Temozolomide | 2016 |
Downregulation of miR-137 and miR-6500-3p promotes cell proliferation in pediatric high-grade gliomas.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Child; Child, Preschool; Chromosomal Proteins, Non-Histone; Dacarbazine; Down-Regulation; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Glioma; Humans; Kinesins; Male; MicroRNAs; Neoplasm Grading; Oncogene Proteins; Temozolomide | 2016 |
Intratumoral heterogeneity identified at the epigenetic, genetic and transcriptional level in glioblastoma.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Biomarkers, Pharmacological; Biomarkers, Tumor; Biopsy; Brain Neoplasms; Dacarbazine; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Female; Follow-Up Studies; Gene Expression Profiling; Glioblastoma; High-Throughput Nucleotide Sequencing; Humans; Male; Middle Aged; Promoter Regions, Genetic; Temozolomide; Tumor Suppressor Proteins | 2016 |
Which elderly newly diagnosed glioblastoma patients can benefit from radiotherapy and temozolomide? A PERNO prospective study.
Topics: Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Glioblastoma; Humans; Promoter Regions, Genetic; Prospective Studies; Survival Analysis; Temozolomide; Tumor Suppressor Proteins | 2016 |
Endoplasmic reticulum stress-inducing drugs sensitize glioma cells to temozolomide through downregulation of MGMT, MPG, and Rad51.
Topics: Animals; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Line, Tumor; Cell Survival; Dacarbazine; DNA Damage; DNA Glycosylases; DNA Modification Methylases; DNA Repair Enzymes; Down-Regulation; Endoplasmic Reticulum Stress; Glioblastoma; Humans; Mice; Pyrans; Rad51 Recombinase; Survival Analysis; Temozolomide; Tumor Suppressor Proteins | 2016 |
Standard chemoradiation for glioblastoma results in progressive brain volume loss.
Topics: Antineoplastic Agents, Alkylating; Brain; Brain Neoplasms; Cranial Irradiation; Dacarbazine; Glioblastoma; Humans; Male | 2016 |
The Error-Prone DNA Polymerase κ Promotes Temozolomide Resistance in Glioblastoma through Rad17-Dependent Activation of ATR-Chk1 Signaling.
Topics: Animals; Antineoplastic Agents, Alkylating; Ataxia Telangiectasia Mutated Proteins; Brain Neoplasms; Cell Cycle; Cell Cycle Proteins; Cell Line, Tumor; Dacarbazine; DNA-Directed DNA Polymerase; Drug Resistance, Neoplasm; Glioblastoma; Heterografts; Humans; Mice; Signal Transduction; Temozolomide | 2016 |
Adaptive Immune Response to and Survival Effect of Temozolomide- and Valproic Acid-induced Autophagy in Glioblastoma.
Topics: Adaptive Immunity; Animals; Antineoplastic Combined Chemotherapy Protocols; Autophagy; Brain Neoplasms; Cancer Vaccines; Cell Line, Tumor; Dacarbazine; Glioblastoma; Mice; Retrospective Studies; Survival Analysis; Temozolomide; Treatment Outcome; Valproic Acid; Xenograft Model Antitumor Assays | 2016 |
Does valproic acid affect tumor growth and improve survival in glioblastomas?
Topics: Anticonvulsants; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Differentiation; Cell Proliferation; Combined Modality Therapy; Dacarbazine; Glioblastoma; Histone Deacetylase Inhibitors; Humans; Seizures; Temozolomide; Valproic Acid | 2016 |
Delivery of a drug cache to glioma cells overexpressing platelet-derived growth factor receptor using lipid nanocarriers.
Topics: Animals; Antineoplastic Agents, Alkylating; Brain; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; Delayed-Action Preparations; Drug Delivery Systems; Glioblastoma; Humans; Mice, Nude; Micelles; Phosphatidylethanolamines; Protons; Receptors, Platelet-Derived Growth Factor; Temozolomide | 2016 |
Pneumocystis jirovecii pneumonia complicating the progress of a patient with glioblastoma multiforme receiving temozolomide.
Topics: Adrenal Cortex Hormones; Aged; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Dacarbazine; Glioblastoma; Humans; Male; Opportunistic Infections; Pneumonia, Pneumocystis; Pulmonary Embolism; Temozolomide; Tomography, X-Ray Computed | 2016 |
Radiotherapy plus concomitant temozolomide in primary gliosarcoma.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemoradiotherapy; Dacarbazine; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Female; Gliosarcoma; Humans; Isocitrate Dehydrogenase; Male; Microsurgery; Middle Aged; Multivariate Analysis; Neurosurgical Procedures; Proportional Hazards Models; Retrospective Studies; Telomerase; Temozolomide; Tumor Suppressor Proteins | 2016 |
A Retrospective Comparative Study of Concomitant Chemoradiotherapy followed by Adjuvant Temozolomide Versus Radiotherapy Alone In Newly Diagnosed Glioblastoma Multiforme - An Experience at Radium Institute, Patna Medical College and Hospital, India.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemoradiotherapy; Combined Modality Therapy; Dacarbazine; Disease-Free Survival; Glioblastoma; Humans; India; Radium; Retrospective Studies; Temozolomide | 2016 |
MRSI-based molecular imaging of therapy response to temozolomide in preclinical glioblastoma using source analysis.
Topics: Animals; Antineoplastic Agents, Alkylating; Biomarkers, Tumor; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; Female; Glioblastoma; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Mice; Mice, Inbred C57BL; Molecular Imaging; Reproducibility of Results; Sensitivity and Specificity; Temozolomide; Treatment Outcome | 2016 |
Too Little, Too Soon: Short-Course Radiotherapy in Elderly Patients With Glioblastoma.
Topics: Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Glioblastoma; Humans; Patients | 2016 |
One Week of Radiotherapy for Glioblastoma: A Noninferiority Trial?
Topics: Brain Neoplasms; Dacarbazine; Glioblastoma; Humans | 2016 |
Sulfasalazine impacts on ferroptotic cell death and alleviates the tumor microenvironment and glioma-induced brain edema.
Topics: Amino Acid Transport System X-AG; Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Steroidal; Brain Edema; Brain Neoplasms; Cell Death; Cell Line, Tumor; Cell Survival; Cells, Cultured; Dacarbazine; Dose-Response Relationship, Drug; Drug Synergism; Glioma; Humans; Magnetic Resonance Imaging; Rats, Wistar; Sulfasalazine; Temozolomide; Tumor Microenvironment | 2016 |
Assessment of early response to tumor-treating fields in newly diagnosed glioblastoma using physiologic and metabolic MRI: initial experience.
Topics: Anisotropy; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cerebral Blood Volume; Choline; Creatine; Dacarbazine; Electric Stimulation Therapy; Electromagnetic Fields; Female; Follow-Up Studies; Glioblastoma; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Middle Aged; Outcome Assessment, Health Care; Temozolomide; Thalamus | 2016 |
Bevacizumab is superior to Temozolomide in causing mitochondrial dysfunction in human brain tumors.
Topics: Angiogenesis Inhibitors; Antineoplastic Agents, Alkylating; Bevacizumab; Brain Neoplasms; Calcium Chloride; Dacarbazine; Dose-Response Relationship, Drug; Edema; Female; Humans; Male; Membrane Potential, Mitochondrial; Microscopy, Electron, Transmission; Mitochondria; Reactive Oxygen Species; Retrospective Studies; Temozolomide; Tumor Cells, Cultured | 2016 |
KLF8 Promotes Temozolomide Resistance in Glioma Cells via β-Catenin Activation.
Topics: Animals; Antineoplastic Agents, Alkylating; Apoptosis; beta Catenin; Blotting, Western; Brain Neoplasms; Caspase 3; Caspase 7; Cell Line, Tumor; Cell Proliferation; Dacarbazine; Drug Resistance, Neoplasm; Glioma; Humans; Kruppel-Like Transcription Factors; Mice; Real-Time Polymerase Chain Reaction; Repressor Proteins; RNA Interference; RNA, Small Interfering; Temozolomide; Xenograft Model Antitumor Assays | 2016 |
Downregulation of HIF-1a sensitizes U251 glioma cells to the temozolomide (TMZ) treatment.
Topics: Apoptosis; Brain Neoplasms; Cell Differentiation; Cell Line, Tumor; Cell Movement; Cell Proliferation; Dacarbazine; Down-Regulation; Gene Expression Regulation, Neoplastic; Glioma; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Neoplasm Invasiveness; Neoplasm Proteins; RNA, Small Interfering; Signal Transduction; Temozolomide; Transfection | 2016 |
Chemical Screening Identifies EUrd as a Novel Inhibitor Against Temozolomide-Resistant Glioblastoma-Initiating Cells.
Topics: 5'-Nucleotidase; Animals; Brain Neoplasms; Carcinogenesis; Cell Cycle Checkpoints; Cell Death; Cell Line, Tumor; Dacarbazine; Drug Evaluation, Preclinical; Drug Resistance, Neoplasm; Glioblastoma; Glycoproteins; Humans; Mice, SCID; Temozolomide; Uracil; Uridine | 2016 |
KCa3.1 channel inhibition sensitizes malignant gliomas to temozolomide treatment.
Topics: Animals; Antineoplastic Agents, Alkylating; Apoptosis; Brain Neoplasms; CDC2 Protein Kinase; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Dacarbazine; Drug Synergism; Drug Therapy, Combination; G2 Phase Cell Cycle Checkpoints; Glioma; Humans; Intermediate-Conductance Calcium-Activated Potassium Channels; Kaplan-Meier Estimate; Mice; Mice, Inbred C57BL; Microglia; Neoplasms, Experimental; Neoplastic Stem Cells; Phosphorylation; Primary Cell Culture; Pyrazoles; Temozolomide | 2016 |
Chemotherapy for intracranial ependymoma in adults.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Dacarbazine; Disease-Free Survival; Ependymoma; Epirubicin; Female; Humans; Ifosfamide; Kaplan-Meier Estimate; Lomustine; Male; Middle Aged; Procarbazine; Temozolomide; Treatment Outcome; Vincristine | 2016 |
CD95 maintains stem cell-like and non-classical EMT programs in primary human glioblastoma cells.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Class Ia Phosphatidylinositol 3-Kinase; Dacarbazine; Drug Combinations; Drug Synergism; Epithelial-Mesenchymal Transition; fas Receptor; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Immunoglobulin G; Neoplasm Recurrence, Local; Neoplastic Stem Cells; Primary Cell Culture; Prognosis; Recombinant Fusion Proteins; RNA, Messenger; Signal Transduction; Spheroids, Cellular; Survival Analysis; Temozolomide | 2016 |
Selective Estrogen Receptor β Agonist LY500307 as a Novel Therapeutic Agent for Glioblastoma.
Topics: Animals; Antineoplastic Agents; Apoptosis; Benzopyrans; Brain Neoplasms; Caspase 3; Cell Line, Tumor; Cisplatin; Dacarbazine; DNA Repair; Estrogen Receptor beta; G2 Phase Cell Cycle Checkpoints; Gene Expression Regulation; Glioblastoma; Humans; Mice; Mice, Inbred C57BL; Mice, Nude; Proto-Oncogene Proteins c-bcl-2; Temozolomide; Xenograft Model Antitumor Assays | 2016 |
Persistent bone marrow depression following short-term treatment with temozolomide.
Topics: Aged; Anemia, Aplastic; Bone Marrow Diseases; Bone Marrow Failure Disorders; Brain Neoplasms; Dacarbazine; Fatal Outcome; Filgrastim; Glioblastoma; Hemoglobinuria, Paroxysmal; Humans; Male; Receptors, Fc; Recombinant Fusion Proteins; Temozolomide; Thrombopoietin; Treatment Failure | 2016 |
Protein Markers Predict Survival in Glioma Patients.
Topics: Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Brain Neoplasms; Dacarbazine; Female; Glioblastoma; Humans; Isocitrate Dehydrogenase; Male; Middle Aged; Prognosis; Proportional Hazards Models; Proteomics; Survival Analysis; Temozolomide; Young Adult | 2016 |
Clinical outcome of an alternative fotemustine schedule in elderly patients with recurrent glioblastoma: a mono-institutional retrospective study.
Topics: Aged; Aged, 80 and over; Antineoplastic Agents; Brain Neoplasms; Dacarbazine; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Drug Administration Schedule; Female; Humans; Male; Neoplasm Recurrence, Local; Nitrosourea Compounds; Organophosphorus Compounds; Recurrence; Retrospective Studies; Survival Analysis; Temozolomide; Treatment Outcome; Tumor Suppressor Proteins | 2016 |
Prognostic and therapeutic factors of gliosarcoma from a multi-institutional series.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Disease-Free Survival; Female; Gliosarcoma; Humans; Male; Middle Aged; Radiotherapy; Retrospective Studies; Salvage Therapy; Temozolomide; Treatment Outcome; Young Adult | 2016 |
Pseudoprogression in children, adolescents and young adults with non-brainstem high grade glioma and diffuse intrinsic pontine glioma.
Topics: Adolescent; Adult; Antineoplastic Agents, Alkylating; Brain Neoplasms; Brain Stem Neoplasms; Child; Child, Preschool; Combined Modality Therapy; Dacarbazine; Disease Progression; Disease-Free Survival; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Female; Glioma; Histones; Humans; Infant; Male; Radiotherapy; Risk Factors; Temozolomide; Treatment Outcome; Tumor Suppressor Proteins; Young Adult | 2016 |
Radiologic response to radiation therapy concurrent with temozolomide for progressive simple dysembryoplastic neuroepithelial tumor.
Topics: Adult; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Female; Glioma; Humans; Neoplasms, Neuroepithelial; Temozolomide | 2016 |
NOTCH blockade combined with radiation therapy and temozolomide prolongs survival of orthotopic glioblastoma.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Benzazepines; Brain Neoplasms; Cell Line, Tumor; Chemoradiotherapy; Dacarbazine; Glioblastoma; Humans; Mice; Mice, Nude; Receptors, Notch; Survival Analysis; Temozolomide; Xenograft Model Antitumor Assays | 2016 |
Accelerated hyperfractionation plus temozolomide in glioblastoma.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Child; Dacarbazine; Disease-Free Survival; Dose Fractionation, Radiation; Female; Follow-Up Studies; Glioblastoma; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Multivariate Analysis; Prognosis; Radiotherapy Planning, Computer-Assisted; Retrospective Studies; Temozolomide; Time Factors; Treatment Outcome; Young Adult | 2016 |
Combined-Modality Therapy With Radiation and Chemotherapy for Elderly Patients With Glioblastoma in the Temozolomide Era: A National Cancer Database Analysis.
Topics: Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cohort Studies; Combined Modality Therapy; Dacarbazine; Databases, Factual; Female; Glioblastoma; Humans; Male; Radiotherapy; Temozolomide; Treatment Outcome | 2016 |
Neurobehavioral radiation mitigation to standard brain cancer therapy regimens by Mn(III) n-butoxyethylpyridylporphyrin-based redox modifier.
Topics: Animals; Antineoplastic Agents; Behavior, Animal; Brain; Brain Neoplasms; Cell Line, Tumor; Cisplatin; Combined Modality Therapy; Cranial Irradiation; Dacarbazine; Female; Humans; Metalloporphyrins; Mice, Inbred C57BL; Mice, Nude; Motor Activity; Neuroprotective Agents; Oxidation-Reduction; Oxidative Stress; Temozolomide; X-Ray Therapy | 2016 |
Frequent Nek1 overexpression in human gliomas.
Topics: Adult; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Dacarbazine; Drug Resistance, Neoplasm; Female; Gene Knockdown Techniques; Glioma; Humans; Immunohistochemistry; Male; NIMA-Related Kinase 1; Temozolomide; Tumor Stem Cell Assay; Up-Regulation | 2016 |
Temozolomide induces radiologic pseudoprogression and tumor cell vanishing in oligodendroglioma.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Diffusion Magnetic Resonance Imaging; Disease Progression; Female; Humans; Isocitrate Dehydrogenase; Male; Middle Aged; Oligodendroglioma; Temozolomide | 2016 |
HDAC6 promotes cell proliferation and confers resistance to temozolomide in glioblastoma.
Topics: Antineoplastic Agents, Alkylating; Apoptosis; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Dacarbazine; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; ErbB Receptors; Glioblastoma; Histone Deacetylase 6; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Protein Stability; Signal Transduction; Temozolomide; Time Factors; Transfection; Up-Regulation | 2016 |
Clonal evolution of glioblastoma under therapy.
Topics: Antineoplastic Agents, Alkylating; Biomarkers, Tumor; Brain Neoplasms; Cell Proliferation; Clonal Evolution; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; Gene Expression Regulation, Neoplastic; Genomics; Glioblastoma; Humans; Isocitrate Dehydrogenase; Latent TGF-beta Binding Proteins; Longitudinal Studies; Mutation; Neoplasm Grading; Neoplasm Recurrence, Local; Survival Rate; Temozolomide; Transcriptome; Transforming Growth Factor beta; Tumor Suppressor Proteins | 2016 |
Long noncoding RNA RP11-838N2.4 enhances the cytotoxic effects of temozolomide by inhibiting the functions of miR-10a in glioblastoma cell lines.
Topics: Animals; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Male; Mice; Mice, Nude; MicroRNAs; RNA, Long Noncoding; Temozolomide; Xenograft Model Antitumor Assays | 2016 |
Malignant transformation of low-grade gliomas in patients undergoing adjuvant therapy.
Topics: Adult; Antineoplastic Agents; Brain Neoplasms; Cell Transformation, Neoplastic; Chemoradiotherapy, Adjuvant; Dacarbazine; Female; Glioma; Humans; Male; Middle Aged; Radiotherapy; Temozolomide | 2017 |
Treatment for Patients With Newly Diagnosed Glioblastoma.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Electric Stimulation Therapy; Female; Glioblastoma; Humans; Maintenance Chemotherapy; Male | 2016 |
Treatment for Patients With Newly Diagnosed Glioblastoma--Reply.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Electric Stimulation Therapy; Female; Glioblastoma; Humans; Maintenance Chemotherapy; Male | 2016 |
Fluoxetine synergizes with temozolomide to induce the CHOP-dependent endoplasmic reticulum stress-related apoptosis pathway in glioma cells.
Topics: Animals; Antineoplastic Agents; Apoptosis; Brain Neoplasms; Caspase 3; Cell Line, Tumor; Cell Proliferation; Dacarbazine; Drug Synergism; Endoplasmic Reticulum Stress; Fluoxetine; Glioma; Membrane Potential, Mitochondrial; Rats; Signal Transduction; Temozolomide; Transcription Factor CHOP | 2016 |
ER stress in temozolomide-treated glioblastomas interferes with DNA repair and induces apoptosis.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; DNA Repair; Endoplasmic Reticulum Stress; Glioblastoma; Humans; Hydroxyquinolines; Male; Mice; Mice, Nude; Temozolomide; Xenograft Model Antitumor Assays | 2016 |
Inhibition of MNK pathways enhances cancer cell response to chemotherapy with temozolomide and targeted radionuclide therapy.
Topics: Aniline Compounds; Antineoplastic Agents; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; Eukaryotic Initiation Factor-4E; Eukaryotic Initiation Factor-4G; Gastrins; Glioma; Humans; Intracellular Signaling Peptides and Proteins; Lutetium; Phosphoproteins; Phosphorylation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Proteomics; Purines; Radioisotopes; Signal Transduction; Temozolomide | 2016 |
Adult-onset atypical teratoid/rhabdoid tumor featuring long spindle cells with nuclear palisading and perivascular pseudorosettes.
Topics: Angiogenesis Inhibitors; Antineoplastic Agents, Alkylating; Bevacizumab; Brain Neoplasms; Combined Modality Therapy; Cranial Irradiation; Dacarbazine; Humans; Magnetic Resonance Imaging; Male; Neurosurgical Procedures; Occipital Lobe; Rhabdoid Tumor; Temozolomide; Teratoma; Treatment Outcome; Young Adult | 2017 |
Valproate in Adjuvant Glioblastoma Treatment.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemotherapy, Adjuvant; Combined Modality Therapy; Dacarbazine; Glioblastoma; Humans; Treatment Outcome; Valproic Acid | 2016 |
Connection between Proliferation Rate and Temozolomide Sensitivity of Primary Glioblastoma Cell Culture and Expression of YB-1 and LRP/MVP.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Proliferation; Dacarbazine; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Immunohistochemistry; Real-Time Polymerase Chain Reaction; RNA, Messenger; Temozolomide; Tumor Cells, Cultured; Vault Ribonucleoprotein Particles; Y-Box-Binding Protein 1 | 2016 |
Concurrent TERT promoter and BRAF V600E mutation in epithelioid glioblastoma and concomitant low-grade astrocytoma.
Topics: Adolescent; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Cranial Irradiation; Dacarbazine; Fatal Outcome; Glioblastoma; Humans; Magnetic Resonance Imaging; Male; Mutation; Neoplasms, Multiple Primary; Neurosurgical Procedures; Promoter Regions, Genetic; Proto-Oncogene Proteins B-raf; Telomerase; Temozolomide; Temporal Lobe | 2017 |
Role of irradiation for patients over 80 years old with glioblastoma: a retrospective cohort study.
Topics: Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cohort Studies; Cranial Irradiation; Dacarbazine; Female; Glioblastoma; Humans; Magnetic Resonance Imaging; Male; Radiation Dose Hypofractionation; Survival Analysis; Temozolomide; Tomography Scanners, X-Ray Computed; Treatment Outcome | 2016 |
Patterns of relapse in patients with high grade glioma receiving combined treatments including stereotactic re-irradiation for a first relapse.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Bevacizumab; Brain Neoplasms; Camptothecin; Chemotherapy, Adjuvant; Dacarbazine; Female; Follow-Up Studies; Glioma; Humans; Irinotecan; Male; Middle Aged; Neoplasm Recurrence, Local; Radiation-Sensitizing Agents; Radiosurgery; Radiotherapy, Adjuvant; Re-Irradiation; Retrospective Studies; Temozolomide | 2016 |
NRF2 and glutathione are key resistance mediators to temozolomide in glioma and melanoma cells.
Topics: Animals; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Buthionine Sulfoximine; Cell Line, Tumor; Dacarbazine; Drug Resistance, Neoplasm; Female; Glioma; Glutathione; Humans; Melanoma; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Mice, Nude; NF-E2-Related Factor 2; Temozolomide; Xenograft Model Antitumor Assays | 2016 |
Augmented HR Repair Mediates Acquired Temozolomide Resistance in Glioblastoma.
Topics: Animals; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; DNA Breaks, Double-Stranded; DNA Modification Methylases; DNA Repair Enzymes; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Mice; Neoplasm Transplantation; Recombinational DNA Repair; Temozolomide; Tumor Suppressor Proteins | 2016 |
Anticancer drug candidate CBL0137, which inhibits histone chaperone FACT, is efficacious in preclinical orthotopic models of temozolomide-responsive and -resistant glioblastoma.
Topics: Animals; Antineoplastic Agents; Apoptosis; Blood-Brain Barrier; Brain Neoplasms; Carbazoles; Cell Proliferation; Dacarbazine; DNA-Binding Proteins; Drug Resistance, Neoplasm; Female; Glioblastoma; High Mobility Group Proteins; Humans; Mice; Mice, Nude; Temozolomide; Transcriptional Elongation Factors; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2017 |
Concurrent Chemoradiotherapy with Temozolomide Followed by Adjuvant Temozolomide for Newly Diagnosed Glioblastoma Patients: A Retrospective Multicenter Observation Study in Korea.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Biopsy; Brain Neoplasms; Chemoradiotherapy; Combined Modality Therapy; Dacarbazine; Disease Progression; Female; Glioblastoma; Humans; Kaplan-Meier Estimate; Magnetic Resonance Imaging; Male; Middle Aged; Temozolomide; Treatment Outcome; Young Adult | 2017 |
miR-29c contribute to glioma cells temozolomide sensitivity by targeting O6-methylguanine-DNA methyltransferases indirectely.
Topics: Alkylating Agents; Animals; Brain Neoplasms; Cell Line, Tumor; Cell Survival; Dacarbazine; DNA Repair; Drug Resistance, Neoplasm; Drug Synergism; Glioma; Humans; Mice; MicroRNAs; Neoplasm Transplantation; O(6)-Methylguanine-DNA Methyltransferase; Sp1 Transcription Factor; Temozolomide; Treatment Outcome | 2016 |
OTX015 (MK-8628), a novel BET inhibitor, displays in vitro and in vivo antitumor effects alone and in combination with conventional therapies in glioblastoma models.
Topics: Acetanilides; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Blood-Brain Barrier; Brain Neoplasms; Camptothecin; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dacarbazine; Drug Synergism; Everolimus; Gene Expression Regulation, Neoplastic; Glioblastoma; Heterocyclic Compounds, 3-Ring; Humans; Irinotecan; Mice; Temozolomide; Xenograft Model Antitumor Assays | 2016 |
Author Response.
Topics: Antineoplastic Agents, Alkylating; Brain; Brain Neoplasms; Cranial Irradiation; Dacarbazine; Glioblastoma; Humans; Male | 2016 |
The effects of sequential treatments on hippocampal volumes in malignant glioma patients.
Topics: Adult; Aged; Antineoplastic Agents; Atrophy; Bevacizumab; Brain Neoplasms; Dacarbazine; Female; Glioma; Hippocampus; Humans; Image Processing, Computer-Assisted; Longitudinal Studies; Magnetic Resonance Imaging; Male; Middle Aged; Radiotherapy; Retrospective Studies; Temozolomide; Treatment Outcome | 2016 |
Prognostic value of the S100B protein in newly diagnosed and recurrent glioma patients: a serial analysis.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Female; Glioma; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Neoplasm Recurrence, Local; Retrospective Studies; S100 Proteins; Statistics, Nonparametric; Temozolomide; Young Adult | 2016 |
Impact of tapering and discontinuation of bevacizumab in patients with progressive glioblastoma.
Topics: Adult; Aged; Antineoplastic Agents, Immunological; Bevacizumab; Brain Neoplasms; Dacarbazine; Disease Progression; Drug Administration Schedule; Female; Glioblastoma; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Regression Analysis; Retrospective Studies; Survival Analysis; Temozolomide; Treatment Outcome; Young Adult | 2016 |
Recurrent Glioblastoma: Combination of High Cerebral Blood Flow with MGMT Promoter Methylation Is Associated with Benefit from Low-Dose Temozolomide Rechallenge at First Recurrence.
Topics: Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Blood Volume; Brain Neoplasms; Cerebrovascular Circulation; Combined Modality Therapy; Contrast Media; Dacarbazine; Disease Progression; Female; Glioblastoma; Humans; Magnetic Resonance Imaging; Male; Meglumine; Middle Aged; Neoplasm Recurrence, Local; O(6)-Methylguanine-DNA Methyltransferase; Organometallic Compounds; Polymerase Chain Reaction; Retrospective Studies; Temozolomide; Treatment Outcome | 2017 |
Slowing down glioblastoma progression in mice by running or the anti-malarial drug dihydroartemisinin? Induction of oxidative stress in murine glioblastoma therapy.
Topics: Animals; Antimalarials; Artemisinins; Brain Neoplasms; Cell Line, Tumor; Combined Modality Therapy; Dacarbazine; Disease Progression; Female; Glioblastoma; Humans; Mice; Mice, Nude; Oxidative Stress; Physical Conditioning, Animal; Reactive Oxygen Species; Temozolomide | 2016 |
miR-423-5p contributes to a malignant phenotype and temozolomide chemoresistance in glioblastomas.
Topics: Animals; Antineoplastic Agents, Alkylating; Apoptosis; Brain Neoplasms; Cell Cycle Proteins; Cell Proliferation; Dacarbazine; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Glioblastoma; Homeodomain Proteins; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Nude; MicroRNAs; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neoplasm Invasiveness; Phenotype; Prognosis; Proto-Oncogene Proteins c-akt; Signal Transduction; Temozolomide; Tumor Cells, Cultured; Tumor Suppressor Proteins; Xenograft Model Antitumor Assays | 2017 |
RLIP76 Depletion Enhances Autophagic Flux in U251 Cells.
Topics: Apoptosis; ATP-Binding Cassette Transporters; Autophagosomes; Autophagy; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; Enzyme Activation; Gene Knockdown Techniques; Glioma; GTPase-Activating Proteins; Humans; Lysosomes; Membrane Fusion; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; RNA, Small Interfering; Signal Transduction; Temozolomide | 2017 |
The survival significance of a measurable enhancing lesion after completing standard treatment for newly diagnosed glioblastoma.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Disease-Free Survival; DNA Modification Methylases; DNA Repair Enzymes; Female; Glioblastoma; Humans; Kaplan-Meier Estimate; Male; Methylation; Middle Aged; Retrospective Studies; Temozolomide; Treatment Outcome; Tumor Suppressor Proteins; Young Adult | 2016 |
Glioblastoma in the elderly - How do we choose who to treat?
Topics: Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Attitude of Health Personnel; Brain Neoplasms; Cognition Disorders; Cross-Sectional Studies; Dacarbazine; Frail Elderly; Geriatric Assessment; Glioblastoma; Humans; Neurologists; Oncologists; Patient Care Team; Patient Selection; Practice Patterns, Physicians'; Referral and Consultation; Temozolomide | 2016 |
Antidepressant drugs can modify cytotoxic action of temozolomide.
Topics: Antidepressive Agents; Antineoplastic Agents, Alkylating; Apoptosis; Brain Neoplasms; Cell Division; Cell Line, Tumor; Cell Survival; Dacarbazine; Depression; Drug Interactions; Fluoxetine; Glioblastoma; Humans; Imipramine; Temozolomide; Tranylcypromine; Tumor Hypoxia | 2017 |
Analysis of Treatment Tolerance and Factors Associated with Overall Survival in Elderly Patients with Glioblastoma.
Topics: Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemoradiotherapy, Adjuvant; Chemotherapy, Adjuvant; Combined Modality Therapy; Dacarbazine; Female; Glioblastoma; Humans; Karnofsky Performance Status; Male; Middle Aged; Multivariate Analysis; Neurosurgical Procedures; Prognosis; Proportional Hazards Models; Radiotherapy, Adjuvant; Retrospective Studies; Survival Rate; Temozolomide; Tumor Suppressor Protein p53 | 2016 |
HMGA1 silencing reduces stemness and temozolomide resistance in glioblastoma stem cells.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; Drug Resistance, Neoplasm; Gene Knockdown Techniques; Gene Silencing; Glioblastoma; HMGA1a Protein; Humans; Neoplastic Stem Cells; RNA, Small Interfering; Temozolomide | 2016 |
Targeting hyperactivated DNA-PKcs by KU0060648 inhibits glioma progression and enhances temozolomide therapy via suppression of AKT signaling.
Topics: Animals; Antineoplastic Agents, Alkylating; Apoptosis; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; DNA-Activated Protein Kinase; Drug Synergism; Female; Glioma; Humans; Mice; Neoplasm Invasiveness; Proto-Oncogene Proteins c-akt; Signal Transduction; Temozolomide; Xenograft Model Antitumor Assays | 2016 |
Integrin αVβ3 silencing sensitizes malignant glioma cells to temozolomide by suppression of homologous recombination repair.
Topics: Animals; Antineoplastic Agents, Alkylating; Apoptosis; Apoptosis Regulatory Proteins; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Dacarbazine; DNA Breaks, Double-Stranded; Down-Regulation; Drug Resistance, Neoplasm; Flow Cytometry; Gene Knockdown Techniques; Glioblastoma; Humans; Integrin alphaVbeta3; Integrin beta3; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Grading; NF-KappaB Inhibitor alpha; Peptides, Cyclic; Phosphorylation; Proto-Oncogene Proteins c-akt; Rad51 Recombinase; Receptor-Interacting Protein Serine-Threonine Kinases; Receptors, Vitronectin; Recombinational DNA Repair; RNA Interference; RNA, Small Interfering; Signal Transduction; Temozolomide; Xenograft Model Antitumor Assays | 2017 |
Predicting the cell death responsiveness and sensitization of glioma cells to TRAIL and temozolomide.
Topics: Antineoplastic Agents, Alkylating; Apoptosis; Biphenyl Compounds; Brain Neoplasms; Cell Line, Tumor; Cell Survival; Dacarbazine; Drug Resistance, Neoplasm; Glioblastoma; Glioma; Humans; Models, Theoretical; Nitrophenols; Piperazines; Signal Transduction; Sulfonamides; Systems Biology; Temozolomide; TNF-Related Apoptosis-Inducing Ligand; Treatment Outcome | 2016 |
A combination of TERT promoter mutation and MGMT methylation status predicts clinically relevant subgroups of newly diagnosed glioblastomas.
Topics: Adult; Antineoplastic Agents, Alkylating; Biomarkers, Tumor; Brain Neoplasms; Cohort Studies; Combined Modality Therapy; Dacarbazine; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Female; Glioblastoma; Humans; Isocitrate Dehydrogenase; Japan; Male; Middle Aged; Mutation; Promoter Regions, Genetic; Survival Analysis; Telomerase; Temozolomide; Tumor Suppressor Proteins | 2016 |
GSK621 Targets Glioma Cells via Activating AMP-Activated Protein Kinase Signalings.
Topics: AMP-Activated Protein Kinases; Antineoplastic Agents; Apoptosis; Brain Neoplasms; Cell Line, Tumor; Cell Survival; Dacarbazine; Down-Regulation; Drug Resistance, Neoplasm; Enzyme Activation; Gene Knockdown Techniques; Glioma; Humans; Imidazoles; Pyrimidinones; Signal Transduction; Temozolomide; Tetraspanins; TOR Serine-Threonine Kinases | 2016 |
Serial analysis of 3D H-1 MRSI for patients with newly diagnosed GBM treated with combination therapy that includes bevacizumab.
Topics: Adult; Aged; Antineoplastic Agents, Immunological; Aspartic Acid; Bevacizumab; Brain Neoplasms; Choline; Creatine; Dacarbazine; Female; Glioblastoma; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Proton Therapy; Statistics, Nonparametric; Temozolomide; Young Adult | 2016 |
Validation of the high-performance of pyrosequencing for clinical MGMT testing on a cohort of glioblastoma patients from a prospective dedicated multicentric trial.
Topics: Adult; Aged; Brain Neoplasms; Dacarbazine; Disease-Free Survival; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Female; Glioblastoma; Humans; Male; Middle Aged; Promoter Regions, Genetic; Prospective Studies; Reproducibility of Results; Sequence Analysis, DNA; Temozolomide; Tumor Suppressor Proteins; Young Adult | 2016 |
Molecular dissection of the valproic acid effects on glioma cells.
Topics: Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Chromatin; Dacarbazine; Decision Support Systems, Clinical; DNA Repair; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; Glioblastoma; Glioma; High-Throughput Nucleotide Sequencing; Histone Deacetylase Inhibitors; Histones; Humans; RNA; RNA, Small Interfering; Temozolomide; Transcription, Genetic; Treatment Outcome; Valproic Acid | 2016 |
Zinc enhances temozolomide cytotoxicity in glioblastoma multiforme model systems.
Topics: Animals; Antineoplastic Agents, Alkylating; Apoptosis; Apoptosis Regulatory Proteins; bcl-2-Associated X Protein; Brain Neoplasms; Caspase 3; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dacarbazine; Disease Models, Animal; Drug Synergism; Glioblastoma; Humans; Ki-67 Antigen; Mice; Temozolomide; Tumor Burden; Xenograft Model Antitumor Assays; Zinc | 2016 |
Reversibility of glioma stem cells' phenotypes explains their complex in vitro and in vivo behavior: Discovery of a novel neurosphere-specific enzyme, cGMP-dependent protein kinase 1, using the genomic landscape of human glioma stem cells as a discovery t
Topics: Animals; Apoptosis; Biomarkers, Tumor; Brain Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Chemotaxis; Cyclic GMP-Dependent Protein Kinase Type I; Dacarbazine; Doxorubicin; Female; Glioblastoma; Glioma; Humans; Male; Mice; Mice, Transgenic; Neoplasm Invasiveness; Neoplastic Stem Cells; Neurons; Oligonucleotide Array Sequence Analysis; Paclitaxel; Phenotype; Stem Cells; Temozolomide | 2016 |
Changes in PlGF and MET-HGF expressions in paired initial and recurrent glioblastoma.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Female; Follow-Up Studies; Gene Expression Regulation, Neoplastic; Glioblastoma; Hepatocyte Growth Factor; Humans; Male; Membrane Proteins; Middle Aged; Neoplasm Recurrence, Local; Proto-Oncogene Proteins c-met; Radiotherapy; RNA, Messenger; Survival Analysis; Temozolomide | 2016 |
Association of early changes in 1H MRSI parameters with survival for patients with newly diagnosed glioblastoma receiving a multimodality treatment regimen.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Choline; Cohort Studies; Combined Modality Therapy; Creatine; Dacarbazine; Female; Follow-Up Studies; Glioblastoma; Humans; Image Processing, Computer-Assisted; Indoles; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Neoplasm Grading; Prognosis; Radiotherapy, Conformal; Survival Rate; Temozolomide; Tumor Burden | 2017 |
Inhibiting stemness and invasive properties of glioblastoma tumorsphere by combined treatment with temozolomide and a newly designed biguanide (HL156A).
Topics: Animals; Antineoplastic Agents, Alkylating; Apoptosis; Brain Neoplasms; Cell Proliferation; Dacarbazine; Drug Therapy, Combination; Epithelial-Mesenchymal Transition; Gene Expression Regulation, Neoplastic; Glioblastoma; Guanidines; Humans; Male; Mice; Mice, Inbred ICR; Mice, Nude; Neoplasm Invasiveness; Neoplastic Stem Cells; Pyrrolidines; Temozolomide; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2016 |
Targeting hexokinase 2 enhances response to radio-chemotherapy in glioblastoma.
Topics: Animals; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Chemoradiotherapy; Dacarbazine; DNA Damage; Glioblastoma; HEK293 Cells; Hexokinase; Humans; Male; MAP Kinase Signaling System; Mice, Inbred NOD; Mice, SCID; RNA Interference; Temozolomide; Xenograft Model Antitumor Assays | 2016 |
Radiation combined with temozolomide contraindicated for young adults diagnosed with anaplastic glioma.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; China; Combined Modality Therapy; Contraindications; Dacarbazine; Female; Glioma; Humans; Male; Middle Aged; Radiotherapy, Adjuvant; Survival Analysis; Temozolomide; Young Adult | 2016 |
Widely metastatic atypical pituitary adenoma with mTOR pathway STK11(F298L) mutation treated with everolimus therapy.
Topics: Adenoma; Adrenocorticotropic Hormone; AMP-Activated Protein Kinase Kinases; Antineoplastic Agents; Brain; Brain Neoplasms; Capecitabine; Dacarbazine; Everolimus; Female; Humans; Ki-67 Antigen; Magnetic Resonance Imaging; Middle Aged; Mutation; Pituitary Neoplasms; Protein Serine-Threonine Kinases; Temozolomide | 2016 |
Artesunate enhances the therapeutic response of glioma cells to temozolomide by inhibition of homologous recombination and senescence.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Artemisinins; Artesunate; Brain Neoplasms; Cell Death; Cellular Senescence; Dacarbazine; Glioma; Homologous Recombination; Humans; Mice; Mice, Nude; Temozolomide; Xenograft Model Antitumor Assays | 2016 |
MRI and 11C-methyl-L-methionine PET Differentiate Bevacizumab True Responders After Initiating Therapy for Recurrent Glioblastoma.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Brain Neoplasms; Dacarbazine; Disease-Free Survival; Female; Glioblastoma; Humans; Magnetic Resonance Imaging; Male; Methionine; Middle Aged; Multimodal Imaging; Neoplasm Recurrence, Local; Neovascularization, Pathologic; Positron-Emission Tomography; Prognosis; Temozolomide; Treatment Outcome; Young Adult | 2016 |
Increased Expression of System xc- in Glioblastoma Confers an Altered Metabolic State and Temozolomide Resistance.
Topics: Amino Acid Transport System y+; Animals; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dacarbazine; Drug Resistance, Neoplasm; Drug Synergism; Gene Knockdown Techniques; Glioblastoma; Glutathione; Humans; Mice; Neoplasm Transplantation; Reactive Oxygen Species; Sulfasalazine; Temozolomide | 2016 |
Targeting Gliomas: Can a New Alkylating Hybrid Compound Make a Difference?
Topics: Antineoplastic Agents, Alkylating; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Autophagy; Brain Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Dacarbazine; Glioma; Humans; Temozolomide | 2017 |
Combination of Palonosetron, Aprepitant, and Dexamethasone Effectively Controls Chemotherapy-induced Nausea and Vomiting in Patients Treated with Concomitant Temozolomide and Radiotherapy: Results of a Prospective Study.
Topics: Adult; Aged; Antiemetics; Antineoplastic Agents, Alkylating; Aprepitant; Brain Neoplasms; Dacarbazine; Dexamethasone; Drug Therapy, Combination; Female; Glioma; Humans; Isoquinolines; Male; Middle Aged; Morpholines; Nausea; Palonosetron; Prospective Studies; Quinuclidines; Serotonin Antagonists; Temozolomide; Vomiting | 2016 |
FK228 augmented temozolomide sensitivity in human glioma cells by blocking PI3K/AKT/mTOR signal pathways.
Topics: Animals; Apoptosis; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Dacarbazine; Depsipeptides; Drug Synergism; Glioma; Humans; Mice; Phosphatidylinositol 3-Kinases; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Signal Transduction; Temozolomide; TOR Serine-Threonine Kinases; Xenograft Model Antitumor Assays | 2016 |
Permeability Surface Area Product Using Perfusion Computed Tomography Is a Valuable Prognostic Factor in Glioblastomas Treated with Radiotherapy Plus Concomitant and Adjuvant Temozolomide.
Topics: Adult; Age Factors; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemotherapy, Adjuvant; Combined Modality Therapy; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; Female; Glioblastoma; Humans; Karnofsky Performance Status; Male; Middle Aged; Perfusion Imaging; Prognosis; Radiotherapy; Retrospective Studies; Temozolomide; Tomography Scanners, X-Ray Computed; Treatment Outcome; Tumor Suppressor Proteins | 2017 |
Inhibition of carbonic anhydrase IX in glioblastoma multiforme.
Topics: Acetazolamide; Antineoplastic Agents; Brain Neoplasms; Carbonic Anhydrase Inhibitors; Carbonic Anhydrase IX; Caspase 3; Cell Death; Cell Line, Tumor; Cell Proliferation; Combined Modality Therapy; Dacarbazine; Drug Carriers; Glioblastoma; Humans; Micelles; Spheroids, Cellular; Temozolomide; Time Factors; Tumor Cells, Cultured | 2016 |
Analysis of expression and prognostic significance of vimentin and the response to temozolomide in glioma patients.
Topics: Adult; Antineoplastic Agents, Alkylating; Biomarkers, Tumor; Brain Neoplasms; Dacarbazine; Female; Follow-Up Studies; Gene Expression Regulation, Neoplastic; Glioma; Humans; Immunoenzyme Techniques; Male; Middle Aged; Neoplasm Grading; Prognosis; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Survival Rate; Temozolomide; Vimentin | 2016 |
Reciprocal regulation of the cholinic phenotype and epithelial-mesenchymal transition in glioblastoma cells.
Topics: Brain Neoplasms; Cell Line, Tumor; Cell Survival; Choline; Choline Kinase; Dacarbazine; Energy Metabolism; Epithelial-Mesenchymal Transition; Gene Knockdown Techniques; Glioblastoma; Humans; Neoplastic Stem Cells; Phenotype; SOXB1 Transcription Factors; Temozolomide; Vimentin; Zinc Finger E-box-Binding Homeobox 1 | 2016 |
MiRNA203 suppresses the expression of protumorigenic STAT1 in glioblastoma to inhibit tumorigenesis.
Topics: Animals; Antineoplastic Agents; Apoptosis; Brain Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Dacarbazine; Dose-Response Relationship, Drug; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Interferons; Male; Mice, Inbred NOD; MicroRNAs; Neoplasm Invasiveness; RNA Interference; Signal Transduction; STAT1 Transcription Factor; Temozolomide; Time Factors; Transfection; Tumor Burden; Xenograft Model Antitumor Assays | 2016 |
3D bioprinted glioma stem cells for brain tumor model and applications of drug susceptibility.
Topics: Alginates; Antineoplastic Agents, Alkylating; Bioprinting; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dacarbazine; Drug Resistance, Neoplasm; Fibrinogen; Gelatin; Glioma; Glucuronic Acid; Hexuronic Acids; Humans; Hydrogels; Models, Biological; Neoplastic Stem Cells; Porosity; Printing, Three-Dimensional; Temozolomide; Tissue Scaffolds; Vascular Endothelial Growth Factor A | 2016 |
IDH mutation and MGMT promoter methylation are associated with the pseudoprogression and improved prognosis of glioblastoma multiforme patients who have undergone concurrent and adjuvant temozolomide-based chemoradiotherapy.
Topics: Adult; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemoradiotherapy, Adjuvant; Dacarbazine; Disease Progression; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Female; Glioblastoma; Humans; Isocitrate Dehydrogenase; Male; Middle Aged; Mutation; Outcome Assessment, Health Care; Prognosis; Promoter Regions, Genetic; Temozolomide; Tumor Suppressor Proteins | 2016 |
Comparative effectiveness of radiotherapy with vs. without temozolomide in older patients with glioblastoma.
Topics: Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cohort Studies; Combined Modality Therapy; Dacarbazine; Female; Glioblastoma; Humans; Male; Retrospective Studies; Survival Analysis; Temozolomide; Treatment Outcome | 2017 |
Metformin treatment reduces temozolomide resistance of glioblastoma cells.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Dacarbazine; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Gene Regulatory Networks; Glioblastoma; Humans; Inhibitory Concentration 50; Metformin; Mice, SCID; Neoplasm Invasiveness; SOXB1 Transcription Factors; Temozolomide; Time Factors; Transcriptome; Tumor Burden; Xenograft Model Antitumor Assays | 2016 |
MicroRNA-101 reverses temozolomide resistance by inhibition of GSK3β in glioblastoma.
Topics: Animals; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Female; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Glioblastoma; Glycogen Synthase Kinase 3 beta; Humans; Male; Mice, Inbred BALB C; Mice, Nude; MicroRNAs; Middle Aged; Promoter Regions, Genetic; RNA Interference; Signal Transduction; Temozolomide; Time Factors; Transfection; Tumor Suppressor Proteins | 2016 |
DNA Repair Capacity in Multiple Pathways Predicts Chemoresistance in Glioblastoma Multiforme.
Topics: Animals; Antineoplastic Agents; Area Under Curve; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; DNA Repair; Drug Resistance, Neoplasm; Glioblastoma; Humans; Mice; Models, Theoretical; ROC Curve; Temozolomide; Xenograft Model Antitumor Assays | 2017 |
Silencing of histone deacetylase 2 suppresses malignancy for proliferation, migration, and invasion of glioblastoma cells and enhances temozolomide sensitivity.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Dacarbazine; Glioblastoma; Histone Deacetylase 2; Humans; Multidrug Resistance-Associated Proteins; Neoplasm Invasiveness; RNA, Small Interfering; Temozolomide | 2016 |
MR Imaging Analysis of Non-Measurable Enhancing Lesions Newly Appearing after Concomitant Chemoradiotherapy in Glioblastoma Patients for Prognosis Prediction.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemoradiotherapy; Dacarbazine; Disease Progression; Female; Glioblastoma; Humans; Kaplan-Meier Estimate; Magnetic Resonance Imaging; Male; Middle Aged; Outcome Assessment, Health Care; Prognosis; Temozolomide; Young Adult | 2016 |
Exosomal miR-221 targets DNM3 to induce tumor progression and temozolomide resistance in glioma.
Topics: Antineoplastic Agents, Alkylating; Apoptosis; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dacarbazine; Disease Progression; Drug Resistance, Neoplasm; Dynamin III; Exosomes; Gene Expression Regulation, Neoplastic; Glioma; Humans; MicroRNAs; Temozolomide; Transcription Factor RelA | 2017 |
Temozolomide inhibits cellular growth and motility via targeting ERK signaling in glioma C6 cells.
Topics: Animals; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Line, Transformed; Cell Line, Tumor; Cell Movement; Cell Proliferation; Dacarbazine; Gene Expression; Glioma; Humans; MAP Kinase Signaling System; Phenotype; Phosphorylation; Rats; Temozolomide; Vascular Endothelial Growth Factor C | 2016 |
Prognostic relevance of miRNA-155 methylation in anaplastic glioma.
Topics: Antineoplastic Agents, Alkylating; Biomarkers, Tumor; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; DNA Methylation; Drug Resistance, Neoplasm; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Genetic Predisposition to Disease; Glioma; Humans; Kaplan-Meier Estimate; MicroRNAs; NF-kappa B; Phenotype; Prognosis; Promoter Regions, Genetic; Proportional Hazards Models; Radiation Tolerance; RNA Interference; Temozolomide; Time Factors; Transcription, Genetic; Transfection | 2016 |
Cutaneous invasive aspergillosis in a patient with glioblastoma receiving long-term temozolomide and corticosteroid therapy.
Topics: Adrenal Cortex Hormones; Aged; Aspergillosis; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Female; Glioblastoma; Humans; Skin; Temozolomide | 2017 |
Valproic acid reduces hair loss and improves survival in patients receiving temozolomide-based radiation therapy for high-grade glioma.
Topics: Adult; Aged; Aged, 80 and over; Alopecia; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemoradiotherapy; Dacarbazine; Female; Glioma; Histone Deacetylase Inhibitors; Humans; Male; Middle Aged; Temozolomide; Valproic Acid; Young Adult | 2017 |
Silver nanoparticles enhance the sensitivity of temozolomide on human glioma cells.
Topics: Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Dacarbazine; Dose-Response Relationship, Drug; G2 Phase Cell Cycle Checkpoints; Glioma; Humans; Metal Nanoparticles; Silver Compounds; Temozolomide | 2017 |
The Inhibition of microRNA-128 on IGF-1-Activating mTOR Signaling Involves in Temozolomide-Induced Glioma Cell Apoptotic Death.
Topics: Antineoplastic Agents, Alkylating; Apoptosis; Brain Neoplasms; Dacarbazine; Glioma; Humans; Insulin-Like Growth Factor I; Membrane Potential, Mitochondrial; MicroRNAs; Reactive Oxygen Species; Signal Transduction; Survival Rate; Temozolomide; TOR Serine-Threonine Kinases; Tumor Cells, Cultured | 2016 |
GANT61, a GLI inhibitor, sensitizes glioma cells to the temozolomide treatment.
Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; Drug Synergism; Glioma; Humans; Nuclear Proteins; Pyridines; Pyrimidines; Receptor, Notch1; Signal Transduction; Temozolomide; Tumor Suppressor Proteins; Zinc Finger Protein GLI1; Zinc Finger Protein Gli2 | 2016 |
MiR-433-3p suppresses cell growth and enhances chemosensitivity by targeting CREB in human glioma.
Topics: 3' Untranslated Regions; Adult; Brain Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cyclic AMP Response Element-Binding Protein; Dacarbazine; Down-Regulation; Drug Resistance, Neoplasm; Female; Gene Expression Regulation, Neoplastic; Glioma; Humans; Male; MicroRNAs; Middle Aged; Neoplasm Invasiveness; Neoplasm Transplantation; Temozolomide; Young Adult | 2017 |
pH-Sensitive O6-Benzylguanosine Polymer Modified Magnetic Nanoparticles for Treatment of Glioblastomas.
Topics: Brain Neoplasms; Cell Line, Tumor; Dacarbazine; Glioblastoma; Guanosine; Humans; Hydrogen-Ion Concentration; Microscopy, Electron, Transmission; O(6)-Methylguanine-DNA Methyltransferase; Polymers; Spectrophotometry, Ultraviolet; Spectroscopy, Fourier Transform Infrared; Temozolomide | 2017 |
Use of an anti-viral drug, Ribavirin, as an anti-glioblastoma therapeutic.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Antiviral Agents; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Dacarbazine; Drug Repositioning; Female; Glioblastoma; Humans; Mice; Mice, Nude; Rats; Rats, Inbred F344; Ribavirin; Temozolomide; Xenograft Model Antitumor Assays | 2017 |
Immune modulation associated with vascular endothelial growth factor (VEGF) blockade in patients with glioblastoma.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Brain Neoplasms; Chemoradiotherapy; Cytokines; Dacarbazine; Disease-Free Survival; Female; Glioblastoma; Humans; Immunotherapy; Leukocytes, Mononuclear; Male; Middle Aged; T-Lymphocytes, Regulatory; Temozolomide; Vascular Endothelial Growth Factor A | 2017 |
Case 38-2016. A 52-Year-Old Woman with Recurrent Oligodendroglioma.
Topics: Antineoplastic Agents, Alkylating; Biopsy; Brain Neoplasms; Chemotherapy, Adjuvant; Dacarbazine; Diagnosis, Differential; Female; Frontal Lobe; Humans; Ki-67 Antigen; Magnetic Resonance Imaging; Middle Aged; Mutation; Neoplasm Recurrence, Local; Oligodendroglioma; Temozolomide | 2016 |
Pathological characterization of nivolumab-related liver injury in a patient with glioblastoma.
Topics: Aged; Antibodies, Monoclonal; Antineoplastic Agents; Autoimmunity; Brain Neoplasms; Chemical and Drug Induced Liver Injury; Dacarbazine; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Glioblastoma; Humans; Isocitrate Dehydrogenase; Male; Neoplasm Staging; Nivolumab; Programmed Cell Death 1 Receptor; Temozolomide; Tumor Suppressor Proteins | 2016 |
Regression of a glioblastoma multiforme: spontaneous versus a potential antineoplastic effect of dexamethasone and levetiracetam.
Topics: Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Cognition Disorders; Dacarbazine; Dexamethasone; Glioblastoma; Humans; Levetiracetam; Magnetic Resonance Imaging; Male; Middle Aged; Neoplasm Regression, Spontaneous; Neoplasms, Second Primary; Piracetam; Temozolomide | 2016 |
Prognostic parameters and outcome after re-irradiation for progressive glioblastoma.
Topics: Adult; Aged; Brain Neoplasms; Dacarbazine; Female; Glioblastoma; Humans; Male; Middle Aged; Radiosurgery; Re-Irradiation; Survival Analysis; Temozolomide | 2017 |
Comments regarding "Hepatotoxicity by combination treatment of temozolomide, artesunate and Chinese herbs in a glioblastoma multiforme patient: case report review of the literature".
Topics: Artemisinins; Artesunate; Brain Neoplasms; Chemical and Drug Induced Liver Injury; Dacarbazine; Glioblastoma; Humans; Temozolomide | 2017 |
Acute liver injury induced by levetiracetam and temozolomide co-treatment.
Topics: Adult; Aged; Anticonvulsants; Antineoplastic Agents, Alkylating; Brain Neoplasms; Case-Control Studies; Chemical and Drug Induced Liver Injury; Dacarbazine; Drug Therapy, Combination; Female; Humans; Israel; Levetiracetam; Liver Function Tests; Male; Middle Aged; Multivariate Analysis; Piracetam; Regression Analysis; Retrospective Studies; Temozolomide | 2017 |
Role of miR-223/paired box 6 signaling in temozolomide chemoresistance in glioblastoma multiforme cells.
Topics: 3' Untranslated Regions; Antagomirs; Antineoplastic Agents, Alkylating; Base Sequence; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; Drug Resistance, Neoplasm; Glioblastoma; Humans; MicroRNAs; PAX6 Transcription Factor; RNA Interference; RNA, Small Interfering; Sequence Alignment; Signal Transduction; Temozolomide | 2017 |
Up-regulation of miR-497 confers resistance to temozolomide in human glioma cells by targeting mTOR/Bcl-2.
Topics: 3' Untranslated Regions; Animals; Antineoplastic Agents, Alkylating; Apoptosis; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Dacarbazine; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Glioma; Humans; Mice; MicroRNAs; Proto-Oncogene Proteins c-bcl-2; Signal Transduction; Temozolomide; TOR Serine-Threonine Kinases; Up-Regulation | 2017 |
The efficacy and roles of combining temozolomide with whole brain radiotherapy in protection neurocognitive function and improvement quality of life of non-small-cell lung cancer patients with brain metastases.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Carcinoma, Non-Small-Cell Lung; Chemoradiotherapy; Cranial Irradiation; Dacarbazine; Female; Follow-Up Studies; Humans; Lung Neoplasms; Male; Middle Aged; Neoplasm Staging; Neurocognitive Disorders; Prognosis; Quality of Life; Retrospective Studies; Survival Rate; Temozolomide | 2017 |
Mesenchymal subtype of glioblastomas with high DNA-PKcs expression is associated with better response to radiotherapy and temozolomide.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; DNA-Activated Protein Kinase; Female; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Hyaluronan Receptors; Ku Autoantigen; Male; Middle Aged; Nuclear Proteins; Oligodendrocyte Transcription Factor 2; Prognosis; Retrospective Studies; Survival Analysis; Temozolomide; Tissue Array Analysis | 2017 |
Identification of aurintricarboxylic acid as a selective inhibitor of the TWEAK-Fn14 signaling pathway in glioblastoma cells.
Topics: Animals; Antineoplastic Agents, Alkylating; Aurintricarboxylic Acid; Brain Neoplasms; Cell Line, Tumor; Cell Movement; Cell Survival; Cytokine TWEAK; Dacarbazine; Drug Synergism; Glioblastoma; HEK293 Cells; Humans; Kaplan-Meier Estimate; Mice, Nude; Molecular Structure; Receptors, Tumor Necrosis Factor; RNA Interference; Signal Transduction; Small Molecule Libraries; Temozolomide; Tumor Necrosis Factors; TWEAK Receptor; Xenograft Model Antitumor Assays | 2017 |
Overexpression of ILK promotes temozolomide resistance in glioma cells.
Topics: Antineoplastic Agents, Alkylating; bcl-2-Associated X Protein; Brain Neoplasms; Caspase 3; Cell Line, Tumor; Cell Proliferation; Dacarbazine; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Gene Expression; Glioma; Humans; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-bcl-2; RNA, Messenger; Temozolomide | 2017 |
The PI3K inhibitor GDC-0941 enhances radiosensitization and reduces chemoresistance to temozolomide in GBM cell lines.
Topics: Antineoplastic Agents; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Brain Neoplasms; Cell Cycle; Cell Line, Tumor; Cell Movement; Cell Survival; Dacarbazine; Glioblastoma; Humans; Indazoles; Neoplasm Invasiveness; Phosphatidylinositol 3-Kinase; Phosphoinositide-3 Kinase Inhibitors; Radiation-Sensitizing Agents; Signal Transduction; Sulfonamides; Temozolomide | 2017 |
Impact of Including Peritumoral Edema in Radiotherapy Target Volume on Patterns of Failure in Glioblastoma following Temozolomide-based Chemoradiotherapy.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Edema; Brain Neoplasms; Chemoradiotherapy; Cohort Studies; Dacarbazine; Disease Progression; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Dose-Response Relationship, Radiation; Female; Gamma Rays; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Male; Middle Aged; Promoter Regions, Genetic; Survival Analysis; Temozolomide; Tumor Suppressor Proteins | 2017 |
DNA-Targeted Inhibition of MGMT.
Topics: Antineoplastic Agents, Alkylating; Apoptosis; Brain Neoplasms; Dacarbazine; DNA; DNA Modification Methylases; DNA Repair Enzymes; Glioma; Guanine; Humans; Temozolomide; Tumor Cells, Cultured; Tumor Suppressor Proteins | 2017 |
FoxM1-mediated RFC5 expression promotes temozolomide resistance.
Topics: Brain Neoplasms; Cell Line, Tumor; Dacarbazine; DNA Repair; Drug Resistance, Neoplasm; Forkhead Box Protein M1; Glioma; Humans; O(6)-Methylguanine-DNA Methyltransferase; Promoter Regions, Genetic; Replication Protein C; Temozolomide; Thiostrepton | 2017 |
MALAT1 is a prognostic factor in glioblastoma multiforme and induces chemoresistance to temozolomide through suppressing miR-203 and promoting thymidylate synthase expression.
Topics: Antineoplastic Agents, Alkylating; Apoptosis; Biomarkers, Tumor; Brain Neoplasms; Cell Cycle; Cell Proliferation; Dacarbazine; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; MicroRNAs; Neoplasm Staging; Prognosis; RNA, Long Noncoding; Survival Rate; Temozolomide; Thymidylate Synthase; Tumor Cells, Cultured | 2017 |
High-dose Neural Stem Cell Radiation May Not Improve Survival in Glioblastoma.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemoradiotherapy, Adjuvant; Contrast Media; Dacarbazine; Disease-Free Survival; DNA Modification Methylases; DNA Repair Enzymes; Female; Follow-Up Studies; Glioblastoma; Humans; Magnetic Resonance Imaging; Male; Medication Adherence; Middle Aged; Neural Stem Cells; Radiotherapy Dosage; Survival Rate; Temozolomide; Tomography, X-Ray Computed; Tumor Suppressor Proteins | 2017 |
The Effect of Ascorbic Acid over the Etoposide- and Temozolomide-Mediated Cytotoxicity in Glioblastoma Cell Culture: A Molecular Study.
Topics: Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Ascorbic Acid; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Central Nervous System Neoplasms; Dacarbazine; DNA Damage; Drug Synergism; Etoposide; Glioblastoma; Humans; Temozolomide | 2018 |
Temozolomide during radiotherapy of glioblastoma multiforme : Daily administration improves survival.
Topics: Adult; Aged; Brain Neoplasms; Chemoradiotherapy; Combined Modality Therapy; Dacarbazine; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Follow-Up Studies; Glioblastoma; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Radiotherapy Dosage; Retrospective Studies; Survival Rate; Temozolomide; Young Adult | 2017 |
Chemosensitivity of IDH1-Mutated Gliomas Due to an Impairment in PARP1-Mediated DNA Repair.
Topics: Brain Neoplasms; Cell Line, Tumor; Dacarbazine; DNA Repair; Glioma; Humans; Isocitrate Dehydrogenase; Mutation; Phthalazines; Piperazines; Poly (ADP-Ribose) Polymerase-1; Temozolomide | 2017 |
The clinical value of patient-derived glioblastoma tumorspheres in predicting treatment response.
Topics: Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemoradiotherapy; Dacarbazine; Disease-Free Survival; Female; Glioblastoma; Humans; Male; Middle Aged; Temozolomide | 2017 |
A mathematical model of low grade gliomas treated with temozolomide and its therapeutical implications.
Topics: Brain Neoplasms; Cell Proliferation; Dacarbazine; Disease Progression; Female; Glioma; Humans; Male; Middle Aged; Models, Biological; Neoplasm Grading; Temozolomide | 2017 |
miR-124 suppresses glioblastoma growth and potentiates chemosensitivity by inhibiting AURKA.
Topics: 3' Untranslated Regions; Aged; Antineoplastic Combined Chemotherapy Protocols; Aurora Kinase A; Azepines; Base Sequence; Blotting, Western; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Dacarbazine; Female; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Kaplan-Meier Estimate; Male; MicroRNAs; Middle Aged; Pyrimidines; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Sequence Homology, Nucleic Acid; Temozolomide; Tumor Burden; Xenograft Model Antitumor Assays | 2017 |
FoxO3a induces temozolomide resistance in glioblastoma cells via the regulation of β-catenin nuclear accumulation.
Topics: Apoptosis; beta Catenin; Brain Neoplasms; Cell Line, Tumor; Cell Nucleus; Cell Proliferation; Dacarbazine; Drug Resistance, Neoplasm; Forkhead Box Protein O3; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Temozolomide; Up-Regulation | 2017 |
Theranostic 3-Dimensional nano brain-implant for prolonged and localized treatment of recurrent glioma.
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Cell Line; Dacarbazine; Delayed-Action Preparations; Disease Models, Animal; Drug Carriers; Glioma; Humans; Nanofibers; Neoplasm Recurrence, Local; Rats, Wistar; Survival Analysis; Temozolomide; Theranostic Nanomedicine | 2017 |
Predictive models for diffuse low-grade glioma patients under chemotherapy.
Topics: Brain Neoplasms; Dacarbazine; Databases, Factual; Glioma; Humans; Linear Models; Magnetic Resonance Imaging; Models, Theoretical; Neoplasm Grading; Temozolomide | 2016 |
A Case of Therapy-Related Acute Myeloid Leukemia Associated with Adjuvant Temozolomide Chemotherapy for Anaplastic Astrocytoma.
Topics: Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Chemotherapy, Adjuvant; Dacarbazine; Humans; Leukemia, Myeloid, Acute; Male; Temozolomide | 2017 |
Rutin increases the cytotoxicity of temozolomide in glioblastoma via autophagy inhibition.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Autophagy; Brain Neoplasms; Cell Line, Tumor; Cell Survival; Dacarbazine; Drug Synergism; Glioblastoma; Humans; Mice; Mice, Nude; Rutin; Temozolomide; Xenograft Model Antitumor Assays | 2017 |
Limited role for extended maintenance temozolomide for newly diagnosed glioblastoma.
Topics: Adult; Age Factors; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cohort Studies; Dacarbazine; Disease-Free Survival; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Female; Glioblastoma; Humans; Isocitrate Dehydrogenase; Magnetic Resonance Imaging; Male; Middle Aged; Mutation; Sex Factors; Statistics, Nonparametric; Temozolomide; Treatment Outcome; Tumor Suppressor Proteins; Young Adult | 2017 |
Novel recursive partitioning analysis classification for newly diagnosed glioblastoma: A multi-institutional study highlighting the MGMT promoter methylation and IDH1 gene mutation status.
Topics: Adult; Aged; Brain Neoplasms; Dacarbazine; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Female; Glioblastoma; Humans; Isocitrate Dehydrogenase; Male; Middle Aged; Mutation; Promoter Regions, Genetic; Temozolomide; Tumor Suppressor Proteins | 2017 |
Management of malignant glioma--quo vadis?
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemotherapy, Adjuvant; Dacarbazine; Glioma; Humans; Temozolomide; Treatment Outcome | 2008 |
Temozolomide in newly diagnosed malignant gliomas: administered concomitantly with radiotherapy, and thereafter as consolidation treatment.
Topics: Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemotherapy, Adjuvant; Dacarbazine; Female; Glioma; Humans; Male; Middle Aged; Retrospective Studies; Temozolomide; Treatment Outcome | 2008 |
Accelerated hypofractionated intensity-modulated radiotherapy with concurrent and adjuvant temozolomide for patients with glioblastoma multiforme: a safety and efficacy analysis.
Topics: Adult; Aged; Analysis of Variance; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemotherapy, Adjuvant; Dacarbazine; Disease-Free Survival; Dose Fractionation, Radiation; Drug Administration Schedule; Female; Glioblastoma; Humans; Male; Methylation; Middle Aged; O(6)-Methylguanine-DNA Methyltransferase; Radiotherapy, Intensity-Modulated; Retrospective Studies; Temozolomide; Treatment Outcome; Tumor Burden | 2009 |
Individual adjuvant therapy for malignant gliomas based on O6-methylguanine-DNA methyltransferase messenger RNA quantitation by real-time reverse-transcription polymerase chain-reaction.
Topics: Adult; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Evidence-Based Medicine; Female; Glioma; Humans; Male; Middle Aged; O(6)-Methylguanine-DNA Methyltransferase; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Survival Rate; Temozolomide | 2008 |
Autophagy-inducing agents augment the antitumor effect of telerase-selve oncolytic adenovirus OBP-405 on glioblastoma cells.
Topics: Adenoviridae; Animals; Autophagy; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; Genetic Therapy; Glioblastoma; Mice; Oncolytic Virotherapy; Oncolytic Viruses; Sirolimus; Temozolomide | 2008 |
Temozolomide preferentially depletes cancer stem cells in glioblastoma.
Topics: AC133 Antigen; Antigens, CD; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Line, Tumor; Cell Separation; Cells, Cultured; Dacarbazine; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Drug Resistance, Neoplasm; Flow Cytometry; Glioblastoma; Glycoproteins; Humans; Neoplastic Stem Cells; Peptides; Temozolomide; Tumor Suppressor Proteins | 2008 |
Enhancement of survival of 9L gliosarcoma bearing rats following intracerebral delivery of drugs in combination with microbeam radiation therapy.
Topics: Animals; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Line, Tumor; Chemotherapy, Adjuvant; Dacarbazine; Gliosarcoma; Injections, Intralesional; Male; Radiotherapy, High-Energy; Rats; Rats, Inbred F344; Survival Analysis; Survival Rate; Synchrotrons; Temozolomide; Treatment Outcome | 2008 |
Enhanced antitumor effect of combined-modality treatment using convection-enhanced delivery of hydrophilic nitrosourea with irradiation or systemic administration of temozolomide in intracranial brain tumor xenografts.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cell Line, Tumor; Combined Modality Therapy; Convection; Cranial Irradiation; Dacarbazine; Disease Models, Animal; Drug Delivery Systems; Gliosarcoma; Injections, Intraperitoneal; Male; Nimustine; Rats; Rats, Inbred F344; Survival Analysis; Survival Rate; Temozolomide; Treatment Outcome; Xenograft Model Antitumor Assays | 2008 |
A novel tool to analyze MRI recurrence patterns in glioblastoma.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Glioblastoma; Humans; Image Interpretation, Computer-Assisted; Magnetic Resonance Imaging; Neoplasm Recurrence, Local; Radiography; Radiotherapy; Randomized Controlled Trials as Topic; Temozolomide | 2008 |
Mismatch repair deficiency does not mediate clinical resistance to temozolomide in malignant glioma.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Base Pair Mismatch; Brain Neoplasms; Dacarbazine; DNA Mismatch Repair; Drug Resistance, Neoplasm; Female; Glioblastoma; Glioma; Humans; Male; Middle Aged; O(6)-Methylguanine-DNA Methyltransferase; Temozolomide | 2008 |
Efficacy of the HSP90 inhibitor 17-AAG in human glioma cell lines and tumorigenic glioma stem cells.
Topics: Animals; Antineoplastic Agents, Alkylating; Benzoquinones; Blotting, Western; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; Drug Therapy, Combination; ErbB Receptors; Glioma; HSP90 Heat-Shock Proteins; Humans; Lactams, Macrocyclic; Mice; Mice, Nude; Mice, SCID; PTEN Phosphohydrolase; Radiation Tolerance; Stem Cells; Temozolomide; Tumor Suppressor Protein p53 | 2009 |
A MDR1 (ABCB1) gene single nucleotide polymorphism predicts outcome of temozolomide treatment in glioblastoma patients.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Brain Neoplasms; Dacarbazine; Drug Resistance, Neoplasm; Female; Gene Frequency; Genotype; Glioblastoma; Humans; K562 Cells; Male; Middle Aged; Polymorphism, Single Nucleotide; Prognosis; Temozolomide; Treatment Outcome; Young Adult | 2009 |
Quality of life in low-grade glioma patients receiving temozolomide.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Dacarbazine; Female; Humans; Longitudinal Studies; Male; Middle Aged; Neoplasm Staging; Oligodendroglioma; Outcome Assessment, Health Care; Prognosis; Prospective Studies; Quality of Life; Sickness Impact Profile; Temozolomide; Treatment Outcome; Young Adult | 2009 |
Disseminated salmonellosis in a patient treated with temozolomide.
Topics: Adult; Anti-Infective Agents; Antineoplastic Agents, Alkylating; Arthritis, Infectious; Astrocytoma; Aza Compounds; Bacteremia; Brain Neoplasms; Dacarbazine; Drainage; Fluoroquinolones; Focal Infection; Humans; Immunocompromised Host; Male; Moxifloxacin; Quinolines; Salmonella Infections; Temozolomide | 2008 |
Therapeutic efficacy of a herpes simplex virus with radiation or temozolomide for intracranial glioblastoma after convection-enhanced delivery.
Topics: Animals; Antineoplastic Agents, Alkylating; Brain Neoplasms; Combined Modality Therapy; Convection; Dacarbazine; Female; Genetic Vectors; Genome, Viral; Glioblastoma; Green Fluorescent Proteins; Herpesvirus 1, Human; Humans; Immediate-Early Proteins; Kaplan-Meier Estimate; Mice; Mice, Inbred BALB C; Mice, Nude; Radiation Tolerance; Temozolomide; Ubiquitin-Protein Ligases | 2008 |
Temozolomide rechallenge in recurrent malignant glioma by using a continuous temozolomide schedule: the "rescue" approach.
Topics: Adult; Aged; Antineoplastic Agents; Brain Neoplasms; Dacarbazine; Disease-Free Survival; Female; Glioma; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Retrospective Studies; Temozolomide | 2008 |
Effects, in an in-vivo model system, of 1,2,3,4-tetrahydroisoquinoline on glioma.
Topics: Animals; Antineoplastic Agents; Astrocytes; Brain Neoplasms; Carmustine; Cell Line, Tumor; Dacarbazine; Disease Models, Animal; Drug Evaluation, Preclinical; Glioma; Male; Rats; Rats, Sprague-Dawley; Temozolomide; Tetrahydroisoquinolines; Tissue Culture Techniques; Xenograft Model Antitumor Assays | 2008 |
Cytotoxic and apoptotic effects of bortezomib and gefitinib compared to alkylating agents on human glioblastoma cells.
Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Apoptosis; Boronic Acids; Bortezomib; Brain Neoplasms; Carboplatin; Carmustine; Cell Line, Tumor; Dacarbazine; Dose-Response Relationship, Drug; ErbB Receptors; Flow Cytometry; Gefitinib; Glial Fibrillary Acidic Protein; Glioblastoma; Immunohistochemistry; Indicators and Reagents; Mice; Proteasome Inhibitors; Pyrazines; Quinazolines; Rats; Temozolomide; Tetrazolium Salts; Thiazoles | 2008 |
DNA repair enzyme expression and differential response to temozolomide in a patient with both glioblastoma and metastatic pancreatic neuroendocrine tumor.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Disease Progression; DNA Repair Enzymes; Fatal Outcome; Glioblastoma; Humans; Liver Neoplasms; Male; Middle Aged; Neuroendocrine Tumors; Pancreatic Neoplasms; Remission Induction; Temozolomide | 2008 |
Sagopilone crosses the blood-brain barrier in vivo to inhibit brain tumor growth and metastases.
Topics: Animals; Antineoplastic Agents, Alkylating; Antineoplastic Agents, Phytogenic; Benzothiazoles; Blood-Brain Barrier; Brain; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; Epothilones; Female; Half-Life; Humans; Male; Mice; Mice, Nude; Paclitaxel; Rats; Rats, Wistar; Survival Rate; Temozolomide; Xenograft Model Antitumor Assays | 2009 |
Frequently asked questions in the medical management of high-grade glioma: a short guide with practical answers.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemotherapy, Adjuvant; Clinical Trials as Topic; Dacarbazine; Drug Administration Schedule; Glioblastoma; Glioma; Humans; Temozolomide | 2008 |
Low-grade glioma: a challenge in therapeutic options: the role of radiotherapy.
Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Chemotherapy, Adjuvant; Dacarbazine; Glioma; Humans; Lomustine; Neoplasm Recurrence, Local; Procarbazine; Prognosis; Radiotherapy; Radiotherapy Dosage; Temozolomide; Vincristine | 2008 |
Feasibility of using bevacizumab with radiation therapy and temozolomide in newly diagnosed high-grade glioma.
Topics: Adult; Aged; Angiogenesis Inhibitors; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents, Alkylating; Bevacizumab; Blood Volume; Brain Neoplasms; Cerebrovascular Circulation; Combined Modality Therapy; Dacarbazine; Feasibility Studies; Female; Glioma; Humans; Male; Middle Aged; Radiotherapy Dosage; Temozolomide; Vascular Endothelial Growth Factor Receptor-2 | 2008 |
The prognostic value of nestin expression in newly diagnosed glioblastoma: report from the Radiation Therapy Oncology Group.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Lineage; Combined Modality Therapy; Dacarbazine; Disease-Free Survival; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Intermediate Filament Proteins; Nerve Tissue Proteins; Nestin; Neurons; Phenotype; Prognosis; Research Design; Temozolomide; Treatment Outcome | 2008 |
Concomitant (without adjuvant) temozolomide and radiation to treat glioblastoma: a retrospective study.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemotherapy, Adjuvant; Combined Modality Therapy; Dacarbazine; Female; Glioblastoma; Humans; Male; Middle Aged; Radiotherapy Dosage; Survival Rate; Temozolomide; Young Adult | 2009 |
Independent association of extent of resection with survival in patients with malignant brain astrocytoma.
Topics: Aged; Analysis of Variance; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Carmustine; Combined Modality Therapy; Dacarbazine; Decanoic Acids; Female; Humans; Kaplan-Meier Estimate; Karnofsky Performance Status; Magnetic Resonance Imaging; Male; Middle Aged; Neurosurgical Procedures; Polyesters; Proportional Hazards Models; Regression Analysis; Retrospective Studies; Survival; Temozolomide; Treatment Outcome | 2009 |
MGMT promoter hypermethylation correlates with a survival benefit from temozolomide in patients with recurrent anaplastic astrocytoma but not glioblastoma.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Dacarbazine; DNA Methylation; Female; Glioblastoma; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Neoplasm Recurrence, Local; O(6)-Methylguanine-DNA Methyltransferase; Prognosis; Promoter Regions, Genetic; Retrospective Studies; Survival Rate; Temozolomide; Young Adult | 2009 |
[Alveolo-interstitial pneumonia due to Temozolamide].
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Bronchoalveolar Lavage; Dacarbazine; Female; Glioblastoma; Humans; Lung Diseases, Interstitial; Lymphocytosis; Middle Aged; Radiography, Thoracic; Temozolomide; Time Factors; Tomography, X-Ray Computed | 2008 |
Proapoptotic receptor agonists, targeted radionuclide therapy, and the treatment of central nervous system malignancies: in regard to Fiveash et Al. (Int J Radiat Oncol Biol Phys 2008;71:507-516).
Topics: Animals; Antibodies, Monoclonal; Antineoplastic Agents, Alkylating; Apoptosis; Brain Neoplasms; Cell Line, Tumor; Combined Modality Therapy; Dacarbazine; Glioma; Humans; Mice; Mice, Nude; Random Allocation; Receptors, TNF-Related Apoptosis-Inducing Ligand; Temozolomide; Xenograft Model Antitumor Assays | 2008 |
Differential effect of sunitinib on the distribution of temozolomide in an orthotopic glioma model.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Brain Neoplasms; Dacarbazine; Drug Interactions; Glioma; Humans; Immunohistochemistry; In Situ Nick-End Labeling; Indoles; Male; Mice; Mice, Nude; Pyrroles; Sunitinib; Temozolomide; Tissue Distribution; Xenograft Model Antitumor Assays | 2009 |
Tuberculosis in a patient on temozolomide: a case report.
Topics: Anti-Infective Agents; Anti-Inflammatory Agents; Anti-Ulcer Agents; Antibiotics, Antitubercular; Anticholesteremic Agents; Anticonvulsants; Antineoplastic Agents, Alkylating; Atorvastatin; Brain Neoplasms; Combined Modality Therapy; Cyclosporine; Dacarbazine; Dexamethasone; Female; Fluoxetine; Glioblastoma; Heptanoic Acids; Humans; Immunosuppressive Agents; Isoniazid; Middle Aged; Omeprazole; Phenobarbital; Prednisone; Pyrazinamide; Pyrroles; Radiotherapy; Red-Cell Aplasia, Pure; Rifampin; Temozolomide; Trimethoprim, Sulfamethoxazole Drug Combination; Tuberculosis, Pulmonary | 2009 |
Characterization of a side population of astrocytoma cells in response to temozolomide.
Topics: Animals; Antineoplastic Agents, Alkylating; Astrocytoma; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Dacarbazine; Disease Models, Animal; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Glioma; Humans; Intermediate Filament Proteins; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Invasiveness; Neoplasm Proteins; Nerve Tissue Proteins; Nestin; RNA-Binding Proteins; RNA, Small Interfering; Temozolomide; Xenograft Model Antitumor Assays | 2008 |
ACNU-based chemotherapy for recurrent glioma in the temozolomide era.
Topics: Adult; Aged; Antineoplastic Agents; Brain Neoplasms; Dacarbazine; Disease-Free Survival; Female; Glioma; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Neoplasm Recurrence, Local; Nimustine; Temozolomide | 2009 |
Treatment-related myelodysplastic syndrome after temozolomide use in a child: first report.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Child; Combined Modality Therapy; Cranial Irradiation; Dacarbazine; Fatal Outcome; Humans; Male; Myelodysplastic Syndromes; Temozolomide | 2008 |
Optimizing radiotherapy of brain tumours by a combination of temozolomide & lonidamine.
Topics: Acridine Orange; Analysis of Variance; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Dacarbazine; Gamma Rays; Humans; Indazoles; Radiation-Sensitizing Agents; Radiotherapy; Temozolomide | 2008 |
Evaluation of MGMT promoter methylation status and correlation with temozolomide response in orthotopic glioblastoma xenograft model.
Topics: Animals; Antineoplastic Agents, Alkylating; Base Sequence; Blotting, Western; Brain Neoplasms; Dacarbazine; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Drug Resistance, Neoplasm; Gene Expression; Glioblastoma; Humans; Mice; Mice, Nude; Molecular Sequence Data; Polymerase Chain Reaction; Promoter Regions, Genetic; Temozolomide; Tumor Suppressor Proteins; Xenograft Model Antitumor Assays | 2009 |
Erythropoietin augments survival of glioma cells after radiation and temozolomide.
Topics: Animals; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Division; Cell Line, Tumor; Cell Movement; Cell Survival; Combined Modality Therapy; Dacarbazine; Erythropoietin; Glioma; Gliosarcoma; Humans; Mice; Mice, Nude; Neoplasm Transplantation; Temozolomide; Transplantation, Heterologous | 2008 |
Activation of KATP channels increases anticancer drug delivery to brain tumors and survival.
Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Blood-Brain Barrier; Brain Neoplasms; Carbon Radioisotopes; Cell Line, Tumor; Dacarbazine; Drug Delivery Systems; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; KATP Channels; Mice; Minoxidil; Survival Rate; Temozolomide; Transplantation, Heterologous; Trastuzumab | 2009 |
Radiochemotherapy in patients with primary glioblastoma comparing two temozolomide dose regimens: is the survival really so impressive?: in regard to Combs et al. (Int J Radiat Oncol Biol Phys 2008;71:999-1005).
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Follow-Up Studies; Glioblastoma; Humans; Reproducibility of Results; Survival Analysis; Survival Rate; Temozolomide; Time Factors | 2008 |
Prolonged and severe thrombocytopenia with pancytopenia induced by radiation-combined temozolomide therapy in a patient with newly diagnosed glioblastoma--analysis of O6-methylguanine-DNA methyltransferase status.
Topics: Antineoplastic Agents, Alkylating; Base Sequence; Blotting, Western; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Female; Glioblastoma; Humans; Magnetic Resonance Imaging; Middle Aged; Neurosurgical Procedures; Pancytopenia; Polymerase Chain Reaction; Radiotherapy; Temozolomide; Thrombocytopenia; Tumor Suppressor Proteins | 2009 |
Targeted inhibition of cyclic AMP phosphodiesterase-4 promotes brain tumor regression.
Topics: Adolescent; Adult; Aged; Animals; Antineoplastic Agents; Blotting, Western; Brain Neoplasms; Cell Line, Tumor; Child; Child, Preschool; Combined Modality Therapy; Cyclic Nucleotide Phosphodiesterases, Type 4; Dacarbazine; Female; Humans; Immunohistochemistry; Male; Mice; Middle Aged; Phosphodiesterase Inhibitors; Rolipram; Temozolomide; Xenograft Model Antitumor Assays | 2008 |
Combining bevacizumab with temozolomide increases the antitumor efficacy of temozolomide in a human glioblastoma orthotopic xenograft model.
Topics: Angiogenesis Inhibitors; Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Brain Neoplasms; Dacarbazine; Endothelium, Vascular; Female; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Mice; Mice, Nude; Neoplasm Transplantation; Neovascularization, Pathologic; Temozolomide | 2008 |
Radiotherapy followed by adjuvant temozolomide treatment of malignant glioma.
Topics: Antineoplastic Agents, Alkylating; Biopsy; Brain Neoplasms; Dacarbazine; Female; Follow-Up Studies; Glioma; Humans; Kaplan-Meier Estimate; Magnetic Resonance Imaging; Male; Middle Aged; Neurosurgical Procedures; Retrospective Studies; Survival Analysis; Temozolomide; Tomography, X-Ray Computed; Treatment Outcome | 2008 |
Pituitary carcinoma presenting with multiple metastases: case report.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Child; Dacarbazine; Female; Humans; Magnetic Resonance Imaging; Papilledema; Pituitary Neoplasms; Temozolomide; Tomography, X-Ray Computed | 2008 |
p53 Small-molecule inhibitor enhances temozolomide cytotoxic activity against intracranial glioblastoma xenografts.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Benzothiazoles; Brain Neoplasms; Dacarbazine; Drug Synergism; Glioblastoma; Humans; Mice; Poly(ADP-ribose) Polymerases; Temozolomide; Toluene; Tumor Suppressor Protein p53; Xenograft Model Antitumor Assays | 2008 |
[Diagnostic and treatment delays do not modify the treatment outcome of patients with multiform glioblastoma].
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Brain Neoplasms; Carmustine; Child; Cisplatin; Combined Modality Therapy; Cranial Irradiation; Dacarbazine; Female; France; Glioblastoma; Humans; Male; Middle Aged; Prognosis; Radiotherapy Dosage; Radiotherapy, Conformal; Retrospective Studies; Survival Rate; Temozolomide; Time Factors; Treatment Outcome; Waiting Lists | 2009 |
Extended exposure to alkylator chemotherapy: delayed appearance of myelodysplasia.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Female; Follow-Up Studies; Glioma; Humans; Male; Middle Aged; Myelodysplastic Syndromes; Nitrosourea Compounds; Reoperation; Survival Analysis; Survivors; Temozolomide; Time Factors | 2009 |
Efficacy of temozolomide for recurrent embryonal brain tumors in children.
Topics: Administration, Oral; Adolescent; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Disease-Free Survival; Female; Follow-Up Studies; Headache; Humans; Magnetic Resonance Imaging; Male; Medulloblastoma; Nausea; Neuroectodermal Tumors, Primitive; Rhabdoid Tumor; Temozolomide; Teratoma; Treatment Outcome; Vomiting | 2009 |
Early clinical and neuroradiological worsening after radiotherapy and concomitant temozolomide in patients with glioblastoma: tumour progression or radionecrosis?
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Ataxia; Brain Neoplasms; Chemotherapy, Adjuvant; Confusion; Dacarbazine; Diagnosis, Differential; Female; Follow-Up Studies; Glioblastoma; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Necrosis; Neoplasm Recurrence, Local; Radiation Injuries; Radiation Tolerance; Radiotherapy, Adjuvant; Reoperation; Temozolomide; Treatment Outcome | 2009 |
A new model for prediction of drug distribution in tumor and normal tissues: pharmacokinetics of temozolomide in glioma patients.
Topics: Administration, Oral; Antineoplastic Agents, Alkylating; Brain; Brain Neoplasms; Carbon Radioisotopes; Dacarbazine; Glioma; Humans; Isotope Labeling; Models, Biological; Positron-Emission Tomography; Radiopharmaceuticals; Temozolomide; Tissue Distribution | 2009 |
Anti-proliferative effect of the gastrin-release peptide receptor antagonist RC-3095 plus temozolomide in experimental glioblastoma models.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Bombesin; Brain Neoplasms; Cell Division; Cell Line, Tumor; Cell Survival; Dacarbazine; Exploratory Behavior; Flow Cytometry; Glioblastoma; Male; Peptide Fragments; Rats; Rats, Wistar; Receptors, Bombesin; Temozolomide | 2009 |
High-dose radiotherapy to 78 Gy with or without temozolomide for high grade gliomas.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Dose-Response Relationship, Radiation; Glioma; Humans; Kaplan-Meier Estimate; Middle Aged; Radiation Dosage; Radiotherapy; Retrospective Studies; Temozolomide; Young Adult | 2009 |
In vitro and in vivo radiosensitization of glioblastoma cells by the poly (ADP-ribose) polymerase inhibitor E7016.
Topics: Animals; Apoptosis; Brain Neoplasms; Cell Line, Tumor; Comet Assay; Dacarbazine; DNA Repair; Enzyme Inhibitors; Glioblastoma; Humans; In Vitro Techniques; Mice; Mitosis; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Radiotherapy; Temozolomide | 2009 |
Pseudoprogression after radiotherapy with concurrent temozolomide for high-grade glioma: clinical observations and working recommendations.
Topics: Adult; Antineoplastic Agents, Alkylating; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Diagnosis, Differential; Diagnostic Errors; Disease Progression; Female; Glioma; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Neoplasm Invasiveness; Neoplasm Recurrence, Local; Retrospective Studies; Temozolomide | 2009 |
Combined magnetic resonance and fluorescence imaging of the living mouse brain reveals glioma response to chemotherapy.
Topics: Animals; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; Glioma; Humans; Magnetic Resonance Imaging; Male; Mice; Microscopy, Fluorescence; Reproducibility of Results; Sensitivity and Specificity; Subtraction Technique; Temozolomide; Treatment Outcome | 2009 |
Risk analysis of severe myelotoxicity with temozolomide: the effects of clinical and genetic factors.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Biomarkers, Tumor; Brain Neoplasms; Dacarbazine; Female; Glioma; Glutathione S-Transferase pi; Humans; Male; Middle Aged; NAD(P)H Dehydrogenase (Quinone); Neoplasm Staging; Neutropenia; O(6)-Methylguanine-DNA Methyltransferase; Polymorphism, Single Nucleotide; Prognosis; Retrospective Studies; Risk Factors; Temozolomide; Thrombocytopenia; Young Adult | 2009 |
Recurrence pattern after temozolomide concomitant with and adjuvant to radiotherapy in newly diagnosed patients with glioblastoma: correlation With MGMT promoter methylation status.
Topics: Adult; Aged; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Female; Glioblastoma; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Promoter Regions, Genetic; Radiotherapy, Adjuvant; Temozolomide; Tumor Suppressor Proteins | 2009 |
Editorial: on the road to multi-modal and pluri-disciplinary treatment of glioblastomas.
Topics: Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Brain Neoplasms; Dacarbazine; Drug Resistance; Glioblastoma; Humans; Neoplasm Invasiveness; Neurosurgical Procedures; Patient Care Team; Sodium-Potassium-Exchanging ATPase; Temozolomide | 2009 |
Tonsillary carcinoma after temozolomide treatment for glioblastoma multiforme: treatment-related or dual-pathology?
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Carcinoma, Squamous Cell; Dacarbazine; Glioblastoma; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Temozolomide; Tonsillar Neoplasms | 2009 |
Impressive regression of visceral and cerebral melanoma metastases under combination treatment including dacarbacine, radiotherapy and celecoxib.
Topics: Adolescent; Antineoplastic Agents, Alkylating; Brain Neoplasms; Celecoxib; Combined Modality Therapy; Cyclooxygenase Inhibitors; Dacarbazine; Female; Humans; Melanoma; Pyrazoles; Skin Neoplasms; Sulfonamides; Tongue Neoplasms | 2009 |
Cilengitide modulates attachment and viability of human glioma cells, but not sensitivity to irradiation or temozolomide in vitro.
Topics: Animals; Antineoplastic Agents, Alkylating; bcl-X Protein; Brain Neoplasms; Cell Adhesion; Cell Movement; Cell Proliferation; Cell Survival; Dacarbazine; DNA Methylation; Drug Therapy, Combination; Gene Silencing; Glioma; Humans; Immunoblotting; In Vitro Techniques; Integrin alphaVbeta3; Mice; Neoplasm Invasiveness; NIH 3T3 Cells; O(6)-Methylguanine-DNA Methyltransferase; Polymerase Chain Reaction; Promoter Regions, Genetic; Receptors, Vitronectin; Snake Venoms; Temozolomide; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2009 |
Treg depletion with a low-dose metronomic temozolomide regimen in a rat glioma model.
Topics: Animals; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Dose-Response Relationship, Drug; Female; Flow Cytometry; Forkhead Transcription Factors; Glioma; Lymphocyte Depletion; Lymphocytes, Tumor-Infiltrating; Rats; Rats, Inbred F344; Spleen; T-Lymphocytes, Regulatory; Temozolomide; Tumor Cells, Cultured | 2009 |
Effect of adding temozolomide to radiation therapy on the incidence of pseudo-progression.
Topics: Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Disease Progression; Disease-Free Survival; Female; Glioblastoma; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Odds Ratio; Radiotherapy, Adjuvant; Retrospective Studies; Temozolomide; Treatment Outcome | 2009 |
Valproic acid related idiosyncratic drug induced hepatotoxicity in a glioblastoma patient treated with temozolomide.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemical and Drug Induced Liver Injury; Chemotherapy, Adjuvant; Cholestasis; Dacarbazine; Glioblastoma; Humans; Liver Failure; Male; Middle Aged; Temozolomide; Valproic Acid | 2008 |
Rechallenge with temozolomide in patients with recurrent gliomas.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain; Brain Neoplasms; Cohort Studies; Dacarbazine; Disease Progression; Disease-Free Survival; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Resistance, Neoplasm; Female; Glioma; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Retrospective Studies; Temozolomide; Treatment Outcome; Young Adult | 2009 |
MSH6 inactivation and emergent temozolomide resistance in human glioblastomas.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemotherapy, Adjuvant; Dacarbazine; Disease Progression; DNA Mismatch Repair; DNA Mutational Analysis; DNA-Binding Proteins; Drug Resistance, Neoplasm; Female; Gene Silencing; Glioblastoma; Humans; Middle Aged; Neoplasm Recurrence, Local; Radiotherapy, Adjuvant; Temozolomide | 2008 |
The side story of stem-like glioma cells.
Topics: Animals; Antineoplastic Agents, Alkylating; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Brain Neoplasms; Dacarbazine; Glioma; Humans; Mice; Neoplasm Proteins; Neoplastic Stem Cells; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Temozolomide | 2009 |
Management of temozolomide toxicity by nurse practitioners in neuro-oncology.
Topics: Analysis of Variance; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chi-Square Distribution; Dacarbazine; Drug Administration Schedule; Drug Monitoring; Glioma; Humans; Lymphopenia; Nausea; Netherlands; Neutropenia; Nurse Practitioners; Nurse's Role; Nursing Evaluation Research; Oncology Nursing; Prospective Studies; Statistics, Nonparametric; Temozolomide; Thrombocytopenia; Treatment Outcome; Vomiting | 2009 |
Homogeneous MGMT immunoreactivity correlates with an unmethylated MGMT promoter status in brain metastases of various solid tumors.
Topics: Alkylating Agents; Brain Neoplasms; Breast Neoplasms; Dacarbazine; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Immunohistochemistry; Kidney Neoplasms; Lung Neoplasms; Melanoma; Polymerase Chain Reaction; Promoter Regions, Genetic; Temozolomide; Tumor Suppressor Proteins | 2009 |
Pathologic correlates of primary central nervous system lymphoma defined in an orthotopic xenograft model.
Topics: Animals; Brain Neoplasms; Cell Polarity; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; Humans; Interleukin-4; Luminescent Measurements; Lymphoma; Macrophages; Mice; Mice, Nude; STAT6 Transcription Factor; Temozolomide; Tumor Suppressor Proteins | 2009 |
Combination of adenoviral virotherapy and temozolomide chemotherapy eradicates malignant glioma through autophagic and apoptotic cell death in vivo.
Topics: Adenoviridae; Animals; Antineoplastic Agents, Alkylating; Apoptosis; Autophagy; Brain Neoplasms; Caspase 3; Cell Line, Tumor; Combined Modality Therapy; Dacarbazine; Female; Glioma; Humans; Mice; Mice, Inbred BALB C; Microtubule-Associated Proteins; Mitosis; Oncolytic Virotherapy; Temozolomide; Xenograft Model Antitumor Assays | 2009 |
Long-term use of temozolomide: could you use temozolomide safely for life in gliomas?
Topics: Adolescent; Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Brain; Brain Neoplasms; Dacarbazine; Drug-Related Side Effects and Adverse Reactions; Glioblastoma; Glioma; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Neurosurgical Procedures; Radiotherapy; Retrospective Studies; Temozolomide; Time; Treatment Outcome | 2009 |
Delivery of temozolomide to the tumor bed via biodegradable gel matrices in a novel model of intracranial glioma with resection.
Topics: Animals; Antineoplastic Agents, Alkylating; Biocompatible Materials; Brain; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Disease Models, Animal; Drug Delivery Systems; Drug Implants; Glioma; Humans; Maximum Tolerated Dose; Mice; Polymers; Rats; Rats, Wistar; Temozolomide; Tissue Distribution; Tumor Cells, Cultured | 2009 |
Cytomegalovirus associated colonic pseudotumor: a consequence of iatrogenic immunosuppression in a patient with primary brain tumor receiving radiation and temozolomide.
Topics: Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cytomegalovirus Infections; Dacarbazine; Female; Humans; Immunosuppression Therapy; Magnetic Resonance Imaging; Opportunistic Infections; Radiotherapy; Temozolomide | 2009 |
CRAdRGDflt-IL24 virotherapy in combination with chemotherapy of experimental glioma.
Topics: Adenoviridae; Animals; Antineoplastic Agents, Alkylating; Apoptosis; Brain Neoplasms; Cell Growth Processes; Cell Line, Tumor; Combined Modality Therapy; Dacarbazine; Female; Genetic Therapy; Genetic Vectors; Glioma; Humans; Interleukins; Mice; Mice, Nude; Oncolytic Virotherapy; Promoter Regions, Genetic; Recombinant Proteins; Temozolomide; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-1; Xenograft Model Antitumor Assays | 2009 |
[Research and therapeutic trials on gliomas].
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Clinical Trials as Topic; Combined Modality Therapy; Dacarbazine; Glioma; Humans; Prognosis; Research; Temozolomide | 2009 |
Glioma-associated endothelial cells are chemoresistant to temozolomide.
Topics: Animals; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Death; Cell Movement; Cell Proliferation; Cell Survival; Dacarbazine; Dose-Response Relationship, Drug; Endothelial Cells; Gene Expression Regulation, Neoplastic; Glioma; Humans; Male; Mice; Neoplasm Transplantation; Neovascularization, Pathologic; Platelet Endothelial Cell Adhesion Molecule-1; Temozolomide; Tetrazolium Salts; Thiazoles; Time Factors; Tumor Cells, Cultured | 2009 |
Preradiation chemotherapy with ACNU-CDDP in patients with newly diagnosed glioblastoma: a retrospective analysis.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Chemotherapy, Adjuvant; Cisplatin; Combined Modality Therapy; Dacarbazine; Drug Therapy, Combination; Female; Glioblastoma; Humans; Male; Middle Aged; Neoplasm Staging; Nimustine; Retrospective Studies; Salvage Therapy; Survival Analysis; Temozolomide | 2009 |
IgE, allergy, and risk of glioma: update from the San Francisco Bay Area Adult Glioma Study in the temozolomide era.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Case-Control Studies; Confounding Factors, Epidemiologic; Dacarbazine; Female; Glioma; Humans; Hypersensitivity; Immunoglobulin E; Immunotherapy; Male; Middle Aged; Odds Ratio; Predictive Value of Tests; Risk Assessment; Risk Factors; San Francisco; Surveys and Questionnaires; Temozolomide | 2009 |
Efficacy of temozolomide treatment in patients with high-grade glioma.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carboplatin; Chemotherapy, Adjuvant; Combined Modality Therapy; Dacarbazine; Etoposide; Female; Glioblastoma; Gliosarcoma; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Oligodendroglioma; Prognosis; Temozolomide; Treatment Outcome; Tumor Necrosis Factor-alpha | 2009 |
EGFRvIII and DNA double-strand break repair: a molecular mechanism for radioresistance in glioblastoma.
Topics: Animals; Astrocytes; Brain Neoplasms; Cell Line, Tumor; Combined Modality Therapy; Dacarbazine; DNA Damage; DNA Repair; DNA, Neoplasm; Drug Resistance, Neoplasm; ErbB Receptors; Fibroblasts; Glioblastoma; Humans; Mice; Radiation, Ionizing; Survival Analysis; Survivors; Temozolomide | 2009 |
Induction of oligodendrogenesis in glioblastoma-initiating cells by IFN-mediated activation of STAT3 signaling.
Topics: Antineoplastic Agents; Brain Neoplasms; Cell Differentiation; Cell Line, Tumor; Dacarbazine; Drug Resistance, Neoplasm; Drug Synergism; Glioblastoma; Humans; Interferon-beta; Oligodendroglia; Signal Transduction; STAT3 Transcription Factor; Temozolomide | 2009 |
Stevens-Johnson Syndrome and toxic epidermal necrolysis overlap due to oral temozolomide and cranial radiotherapy.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Glioblastoma; Humans; Male; Middle Aged; Neck; Radiotherapy; Scalp; Stevens-Johnson Syndrome; Temozolomide; Thorax | 2009 |
Effect of IFN-beta on human glioma cell lines with temozolomide resistance.
Topics: Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Dacarbazine; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Drug Synergism; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Glioma; Humans; Interferon-beta; Promoter Regions, Genetic; RNA, Messenger; Temozolomide; Tumor Suppressor Proteins | 2009 |
Overall survival of newly diagnosed glioblastoma patients receiving carmustine wafers followed by radiation and concurrent temozolomide plus rotational multiagent chemotherapy.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carmustine; Combined Modality Therapy; Dacarbazine; Female; Glioblastoma; Humans; Male; Middle Aged; Retrospective Studies; Survival Analysis; Temozolomide | 2009 |
Temozolomide concomitant and adjuvant to radiotherapy in elderly patients with glioblastoma: correlation with MGMT promoter methylation status.
Topics: Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemotherapy, Adjuvant; Combined Modality Therapy; Dacarbazine; Disease-Free Survival; DNA Methylation; Female; Glioblastoma; Humans; Male; O(6)-Methylguanine-DNA Methyltransferase; Promoter Regions, Genetic; Survival Rate; Temozolomide | 2009 |
Inhibition of c-Jun N-terminal kinase enhances temozolomide-induced cytotoxicity in human glioma cells.
Topics: Activating Transcription Factor 2; Anthracenes; Antineoplastic Agents, Alkylating; beta-Galactosidase; Brain Neoplasms; Cell Death; Cell Division; Cell Line, Tumor; Cell Survival; Cellular Senescence; Dacarbazine; Dose-Response Relationship, Drug; Drug Synergism; G2 Phase; Glioma; Humans; JNK Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Temozolomide; Tumor Suppressor Protein p53 | 2009 |
Extent of MGMT promoter methylation correlates with outcome in glioblastomas given temozolomide and radiotherapy.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Line, Tumor; Chemotherapy, Adjuvant; Dacarbazine; DNA Methylation; Female; Glioblastoma; Humans; Male; Middle Aged; O(6)-Methylguanine-DNA Methyltransferase; Promoter Regions, Genetic; Radiotherapy; Temozolomide; Treatment Outcome; Young Adult | 2009 |
Combined modality treatment of newly diagnosed glioblastoma multiforme in a regional neurosurgical centre.
Topics: Adrenal Cortex Hormones; Adult; Aged; Anticonvulsants; Antineoplastic Agents, Alkylating; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Female; Glioblastoma; Hospitals, Community; Humans; Kaplan-Meier Estimate; Karnofsky Performance Status; Magnetic Resonance Imaging; Male; Middle Aged; Neurosurgical Procedures; Retrospective Studies; Survival; Temozolomide | 2009 |
The prognostic role of Beclin 1 protein expression in high-grade gliomas.
Topics: Antineoplastic Agents, Alkylating; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Biomarkers, Tumor; Brain Neoplasms; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; Glioma; Humans; In Situ Nick-End Labeling; Membrane Proteins; Middle Aged; Prognosis; Survival Analysis; Temozolomide; Tumor Suppressor Proteins | 2009 |
[Central nervous system glioma. Multi-drug chemotherapy including temozolomide].
Topics: Antineoplastic Agents; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Dacarbazine; Glioma; Humans; Interferon-beta; Temozolomide | 2009 |
FEN1 is overexpressed in testis, lung and brain tumors.
Topics: Antineoplastic Agents; Apoptosis; Base Sequence; Brain Neoplasms; Cisplatin; Dacarbazine; Flap Endonucleases; Flow Cytometry; Humans; Lung Neoplasms; Male; Methyl Methanesulfonate; Nimustine; RNA, Messenger; RNA, Small Interfering; Temozolomide; Testicular Neoplasms | 2009 |
Pseudoprogression and MGMT status in glioblastoma patients: implications in clinical practice.
Topics: Aged; Antineoplastic Agents; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Disease Progression; DNA Modification Methylases; DNA Repair Enzymes; Female; Glioblastoma; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Temozolomide; Tumor Suppressor Proteins | 2009 |
Comparing neuropsychological tasks to optimize brief cognitive batteries for brain tumor clinical trials.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Attention; Brain Neoplasms; Cognition Disorders; Dacarbazine; Female; Humans; Language; Male; Memory; Middle Aged; Neuropsychological Tests; Retrospective Studies; Space Perception; Temozolomide | 2010 |
Comment re: Temozolomide preferentially depletes cancer stem cells.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Glioblastoma; Humans; Magnetic Resonance Imaging; Neoplastic Stem Cells; Temozolomide | 2009 |
[Detection of O6-methylguanine-DNA methyltransferase promoter methylation in chemotherapy for glioma].
Topics: Adolescent; Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents, Alkylating; Azacitidine; Brain Neoplasms; Cell Line, Tumor; CpG Islands; Dacarbazine; Decitabine; DNA Methylation; Drug Resistance, Neoplasm; Female; Follow-Up Studies; Glioma; Humans; Male; Middle Aged; Nimustine; O(6)-Methylguanine-DNA Methyltransferase; Promoter Regions, Genetic; Survival Rate; Temozolomide; Young Adult | 2009 |
Perioperative high-dose-rate brachytherapy in the treatment of recurrent malignant gliomas.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Astrocytoma; Brachytherapy; Brain Neoplasms; Chemotherapy, Adjuvant; Combined Modality Therapy; Dacarbazine; Disease-Free Survival; Female; Glioblastoma; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Neoplasm Recurrence, Local; Radiotherapy Dosage; Radiotherapy Planning, Computer-Assisted; Radiotherapy, Adjuvant; Reoperation; Retrospective Studies; Temozolomide; Tomography, X-Ray Computed | 2009 |
Methionine restriction reduces the chemosensitivity of central nervous system tumour cell lines.
Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cell Proliferation; Cerebellar Neoplasms; Cisplatin; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; Drug Resistance, Neoplasm; Fluorometry; Glioma; Glutathione; Humans; Medulloblastoma; Methionine; Methotrexate; Temozolomide; Tumor Cells, Cultured; Tumor Suppressor Proteins | 2009 |
Radiosensitizing effects of temozolomide observed in vivo only in a subset of O6-methylguanine-DNA methyltransferase methylated glioblastoma multiforme xenografts.
Topics: Animals; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Line, Tumor; Combined Modality Therapy; Dacarbazine; Drug Administration Schedule; Genes, erbB-1; Genes, p53; Glioblastoma; Humans; Methylation; Mice; O(6)-Methylguanine-DNA Methyltransferase; PTEN Phosphohydrolase; Radiation-Sensitizing Agents; Random Allocation; Survival Analysis; Temozolomide; Xenograft Model Antitumor Assays | 2009 |
Prognostic and predictive value of p53 in low MGMT expressing glioblastoma treated with surgery, radiation and adjuvant temozolomide chemotherapy.
Topics: Brain Neoplasms; Chemotherapy, Adjuvant; Combined Modality Therapy; Dacarbazine; Disease-Free Survival; DNA Modification Methylases; DNA Repair Enzymes; Female; Glioblastoma; Humans; Immunohistochemistry; Kaplan-Meier Estimate; Male; Predictive Value of Tests; Prognosis; Temozolomide; Treatment Outcome; Tumor Suppressor Protein p53; Tumor Suppressor Proteins | 2010 |
Efficacy of temozolomide as adjuvant chemotherapy after postsurgical radiotherapy alone for glioblastomas.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Case-Control Studies; Chemotherapy, Adjuvant; Child; Child, Preschool; Cohort Studies; Combined Modality Therapy; Dacarbazine; Female; Follow-Up Studies; Glioblastoma; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Neurosurgical Procedures; Nitrosourea Compounds; Retrospective Studies; Survival Analysis; Temozolomide; Young Adult | 2009 |
Cognitive functioning in glioblastoma patients during radiotherapy and temozolomide treatment: initial findings.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents, Alkylating; Attention; Brain Neoplasms; Cognition Disorders; Dacarbazine; Female; Follow-Up Studies; Glioblastoma; Humans; Magnetic Resonance Imaging; Male; Memory; Mental Processes; Middle Aged; Neuropsychological Tests; Psychomotor Performance; Radiotherapy, Adjuvant; Temozolomide; Verbal Learning | 2010 |
Modulation of KCa channels increases anticancer drug delivery to brain tumors and prolongs survival in xenograft model.
Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Benzimidazoles; Blood-Brain Barrier; Brain; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; Drug Delivery Systems; Female; Flow Cytometry; Glioma; Humans; Immunoblotting; Large-Conductance Calcium-Activated Potassium Channel alpha Subunits; Mice; Mice, Nude; Rats; Rats, Nude; Reverse Transcriptase Polymerase Chain Reaction; Survival Analysis; Temozolomide; Trastuzumab; Xenograft Model Antitumor Assays | 2009 |
O(6)-Methylguanine-DNA methyltransferase expression and prognostic value in brain metastases of lung cancers.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; Female; Humans; Immunohistochemistry; Lung Neoplasms; Male; Methylation; Middle Aged; Predictive Value of Tests; Prognosis; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; Survival Analysis; Temozolomide; Tumor Suppressor Proteins | 2010 |
Glioblastoma masquerading as a hypertensive putaminal hemorrhage: a diagnostic pitfall.
Topics: Antihypertensive Agents; Antineoplastic Agents, Alkylating; Biopsy; Brain Neoplasms; Dacarbazine; Diabetes Complications; Diagnosis, Differential; Diagnostic Errors; Fatal Outcome; Glioblastoma; Humans; Hypertension; Magnetic Resonance Imaging; Male; Middle Aged; Putaminal Hemorrhage; Risk Factors; Temozolomide; Tomography, X-Ray Computed; Treatment Failure | 2009 |
Secondary gliosarcoma after diagnosis of glioblastoma: clinical experience with 30 consecutive patients.
Topics: Adult; Aged; Antineoplastic Agents; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Female; Glioblastoma; Gliosarcoma; Humans; Male; Middle Aged; Retrospective Studies; Temozolomide | 2010 |
Concurrent temozolomide and radiation, a reasonable option for elderly patients with glioblastoma multiforme?
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Female; Glioblastoma; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Palliative Care; Radiotherapy, Conformal; Retrospective Studies; Temozolomide | 2010 |
Recurrent glioblastoma of childhood treated with bevacizumab: case report and molecular features.
Topics: Adolescent; Angiogenesis Inhibitors; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents, Alkylating; Bevacizumab; Brain; Brain Neoplasms; Dacarbazine; Glioblastoma; Humans; Magnetic Resonance Imaging; Male; Neoplasm Recurrence, Local; Temozolomide | 2010 |
Recurrent PNET with MGMT methylation responds to temozolomide.
Topics: Adult; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Humans; Magnetic Resonance Imaging; Male; Methylation; Neuroectodermal Tumors, Primitive; O(6)-Methylguanine-DNA Methyltransferase; Temozolomide | 2009 |
The correlation and prognostic significance of MGMT promoter methylation and MGMT protein in glioblastomas.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Female; Gene Expression; Glioblastoma; Humans; Immunohistochemistry; Kaplan-Meier Estimate; Male; Middle Aged; Polymerase Chain Reaction; Prognosis; Promoter Regions, Genetic; Radiotherapy; Temozolomide; Tumor Suppressor Proteins; Young Adult | 2009 |
A mathematical model of brain tumour response to radiotherapy and chemotherapy considering radiobiological aspects.
Topics: Antineoplastic Agents; Brain Neoplasms; Cell Proliferation; Dacarbazine; Dose-Response Relationship, Radiation; Humans; Kaplan-Meier Estimate; Linear Models; Models, Biological; Radiation Tolerance; Randomized Controlled Trials as Topic; Temozolomide; Time Factors | 2010 |
Inter- and intrapatients comparison of WHO grade II glioma kinetics before and after surgical resection.
Topics: Adolescent; Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Child; Dacarbazine; Databases, Factual; Disease Progression; Female; Follow-Up Studies; Glioma; Humans; Kinetics; Linear Models; Magnetic Resonance Imaging; Male; Middle Aged; Neoplasm Recurrence, Local; Neurosurgical Procedures; Oligodendroglioma; Retrospective Studies; Temozolomide; Young Adult | 2010 |
Intrathecal liposomal cytarabine in combination with temozolomide in low-grade oligoastrocytoma with leptomeningeal dissemination.
Topics: Adult; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cytarabine; Dacarbazine; Humans; Injections, Spinal; Liposomes; Magnetic Resonance Imaging; Male; Meningeal Neoplasms; Oligodendroglioma; Temozolomide | 2010 |
Therapy-related myelodysplastic syndrome/acute myeloid leukemia after treatment with temozolomide in a patient with glioblastoma multiforme.
Topics: Adult; Aged; Biopsy; Bone Marrow Cells; Brain Neoplasms; Dacarbazine; Disease Progression; Female; Glioblastoma; Humans; In Situ Hybridization, Fluorescence; Karyotyping; Leukemia, Myeloid, Acute; Magnetic Resonance Imaging; Male; Middle Aged; Myelodysplastic Syndromes; Skin; Temozolomide | 2009 |
Immunological factors relating to the antitumor effect of temozolomide chemoimmunotherapy in a murine glioma model.
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Dacarbazine; Dendritic Cells; Disease Models, Animal; Drug Therapy, Combination; Female; Glioma; Humans; Immunotherapy; Mice; Mice, Inbred C57BL; Survival Analysis; T-Lymphocytes, Regulatory; Temozolomide | 2010 |
The importance of tumor volume in the prognosis of patients with glioblastoma: comparison of computerized volumetry and geometric models.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Camptothecin; Chemotherapy, Adjuvant; Dacarbazine; Disease-Free Survival; Female; Glioblastoma; Humans; Image Processing, Computer-Assisted; Imaging, Three-Dimensional; Irinotecan; Kaplan-Meier Estimate; Magnetic Resonance Imaging; Male; Middle Aged; Models, Theoretical; Radiosurgery; Regression Analysis; Statistics as Topic; Temozolomide; Tumor Burden | 2009 |
Anaplastic glioma: how to prognosticate outcome and choose a treatment strategy. [corrected].
Topics: Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Chemotherapy, Adjuvant; Chromosome Deletion; Chromosomes, Human, Pair 1; Chromosomes, Human, Pair 19; Dacarbazine; Disease-Free Survival; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Gene Expression Regulation, Neoplastic; Glioma; Humans; Lomustine; Procarbazine; Promoter Regions, Genetic; Radiotherapy, Adjuvant; Randomized Controlled Trials as Topic; Research Design; Survival Analysis; Temozolomide; Time Factors; Treatment Failure; Tumor Suppressor Proteins; Vincristine | 2009 |
Six year survival after prolonged temozolomide treatment in a 30-year-old patient with glioblastoma.
Topics: Adult; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Female; Glioblastoma; Humans; Magnetic Resonance Imaging; Survivors; Temozolomide; Treatment Outcome | 2009 |
Inhibition of Y-box binding protein-1 slows the growth of glioblastoma multiforme and sensitizes to temozolomide independent O6-methylguanine-DNA methyltransferase.
Topics: Adult; Animals; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Child; Cluster Analysis; Dacarbazine; DNA-Binding Proteins; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Immunoblotting; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasms, Experimental; Nuclear Proteins; O(6)-Methylguanine-DNA Methyltransferase; RNA Interference; Temozolomide; Transplantation, Heterologous; Tumor Burden; Y-Box-Binding Protein 1 | 2009 |
Trans-sodium crocetinate enhancing survival and glioma response on magnetic resonance imaging to radiation and temozolomide.
Topics: Animals; Antineoplastic Agents, Alkylating; Brain Neoplasms; Carotenoids; Cell Line, Tumor; Combined Modality Therapy; Dacarbazine; Diffusion; Disease Models, Animal; Glioblastoma; Hypoxia, Brain; Kaplan-Meier Estimate; Magnetic Resonance Imaging; Neoplasm Transplantation; Oxygen; Radiation-Sensitizing Agents; Rats; Rats, Sprague-Dawley; Temozolomide; Vitamin A | 2010 |
Brain metastases from melanoma: is there a role for concurrent temozolomide in addition to whole brain radiation therapy?
Topics: Administration, Oral; Aged; Antineoplastic Agents; Brain Neoplasms; Cohort Studies; Combined Modality Therapy; Cranial Irradiation; Dacarbazine; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Kaplan-Meier Estimate; Male; Melanoma; Middle Aged; Radiotherapy Dosage; Retrospective Studies; Risk Assessment; Skin Neoplasms; Survival Analysis; Temozolomide; Treatment Outcome | 2010 |
Neoplastic meningitis from breast cancer: feasibility and activity of long-term intrathecal liposomal Ara-C combined with dose-dense temozolomide.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Breast Neoplasms; Combined Modality Therapy; Cranial Irradiation; Cytarabine; Dacarbazine; Feasibility Studies; Female; Humans; Injections, Spinal; Liposomes; Meningeal Neoplasms; Temozolomide | 2009 |
Clinical characteristics and outcomes for a modern series of primary gliosarcoma patients.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemotherapy, Adjuvant; Combined Modality Therapy; Dacarbazine; Female; Gliosarcoma; Humans; Male; Middle Aged; Temozolomide | 2010 |
Up-front temozolomide in elderly patients with glioblastoma.
Topics: Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Geriatrics; Glioblastoma; Humans; Karnofsky Performance Status; Magnetic Resonance Imaging; Male; Retrospective Studies; Survival Analysis; Temozolomide; Treatment Outcome; Tumor Suppressor Proteins | 2010 |
Bevacizumab and dose-intense temozolomide in recurrent high-grade glioma.
Topics: Adolescent; Adult; Angiogenesis Inhibitors; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Bevacizumab; Brain Neoplasms; Dacarbazine; Disease Progression; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Glioma; Humans; Male; Middle Aged; Recurrence; Temozolomide; Treatment Outcome; Young Adult | 2010 |
Long-term temozolomide treatment induces marked amino metabolism modifications and an increase in TMZ sensitivity in Hs683 oligodendroglioma cells.
Topics: Amino Acids; Animals; Antineoplastic Agents, Alkylating; Apoptosis; Blotting, Western; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Dacarbazine; Female; Gene Expression Regulation, Neoplastic; Genomics; HT29 Cells; Humans; Mice; Mice, Nude; Neoplasm Invasiveness; Neoplastic Stem Cells; Oligodendroglioma; Proteomics; Reverse Transcriptase Polymerase Chain Reaction; Temozolomide; Time Factors; Xenograft Model Antitumor Assays | 2010 |
Patient-tailored, imaging-guided, long-term temozolomide chemotherapy in patients with glioblastoma.
Topics: Adult; Antineoplastic Agents, Alkylating; Brain Neoplasms; Carbon Radioisotopes; Dacarbazine; Dideoxynucleosides; Fluorine Radioisotopes; Glioblastoma; Humans; Methionine; Middle Aged; Radionuclide Imaging; Radiopharmaceuticals; Temozolomide | 2010 |
O6-Methylguanine DNA methyltransferase protein expression in tumor cells predicts outcome of temozolomide therapy in glioblastoma patients.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Biomarkers, Tumor; Blotting, Western; Brain Neoplasms; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; Female; Glioblastoma; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Polymerase Chain Reaction; Promoter Regions, Genetic; Temozolomide; Treatment Outcome; Tumor Suppressor Proteins; Young Adult | 2010 |
Noninvasive detection of temozolomide in brain tumor xenografts by magnetic resonance spectroscopy.
Topics: Animals; Antineoplastic Agents; Blood-Brain Barrier; Brain Neoplasms; Carbon Radioisotopes; Cell Line, Tumor; Dacarbazine; Gadolinium DTPA; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Mice; Temozolomide; Tissue Distribution; Xenograft Model Antitumor Assays | 2010 |
Commentary on Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial (Lancet Oncol. 2009;10:459-466).
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemotherapy, Adjuvant; Clinical Trials, Phase III as Topic; Combined Modality Therapy; Dacarbazine; Glioblastoma; Humans; Randomized Controlled Trials as Topic; Temozolomide; Treatment Outcome | 2010 |
Promoter methylation analysis of O6-methylguanine-DNA methyltransferase in glioblastoma: detection by locked nucleic acid based quantitative PCR using an imprinted gene (SNURF) as a reference.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Carmustine; Dacarbazine; DNA Methylation; Epigenesis, Genetic; Female; Genomic Imprinting; Glioblastoma; Humans; Male; Middle Aged; O(6)-Methylguanine-DNA Methyltransferase; Polymerase Chain Reaction; Promoter Regions, Genetic; Temozolomide | 2010 |
Temozolomide and MGMT forever?
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Clinical Trials as Topic; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; Glioma; Humans; Neoplasm Recurrence, Local; Temozolomide; Tumor Suppressor Proteins | 2010 |
Pseudoprogression following chemoradiotherapy for glioblastoma multiforme.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Disease Progression; Follow-Up Studies; Glioblastoma; Humans; Magnetic Resonance Imaging; Radiotherapy, Adjuvant; Retrospective Studies; Survival Analysis; Temozolomide; Treatment Outcome | 2010 |
Combination of intracranial temozolomide with intracranial carmustine improves survival when compared with either treatment alone in a rodent glioma model.
Topics: Animals; Antineoplastic Agents, Alkylating; Brain Neoplasms; Carmustine; Dacarbazine; Disease Models, Animal; Drug Administration Routes; Drug Therapy, Combination; Female; Glioma; Rats; Rats, Inbred F344; Survival Analysis; Temozolomide; Xenograft Model Antitumor Assays | 2010 |
MGMT modulates glioblastoma angiogenesis and response to the tyrosine kinase inhibitor sunitinib.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Combined Chemotherapy Protocols; Blotting, Western; Brain Neoplasms; Cell Line, Tumor; Cell Separation; Combined Modality Therapy; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; Drug Resistance, Neoplasm; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Gene Expression; Gene Expression Profiling; Glioblastoma; Humans; Indoles; Mice; Mice, Nude; Neovascularization, Pathologic; Protein Kinase Inhibitors; Pyrroles; Radiotherapy; Reverse Transcriptase Polymerase Chain Reaction; Sunitinib; Temozolomide; Tumor Suppressor Proteins; Xenograft Model Antitumor Assays | 2010 |
Patent watch.
Topics: Antineoplastic Agents, Alkylating; Antiparkinson Agents; Benzothiazoles; Brain Neoplasms; Dacarbazine; Humans; Parkinson Disease; Patents as Topic; Pramipexole; Temozolomide; Time Factors | 2010 |
Patterns and timing of recurrence after temozolomide-based chemoradiation for glioblastoma.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Female; Glioblastoma; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Neoplasm Recurrence, Local; Radiotherapy Dosage; Retrospective Studies; Temozolomide; Time Factors | 2010 |
Can hsp90alpha-targeted siRNA combined with TMZ be a future therapy for glioma?
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Line, Tumor; Cell Survival; Chemotherapy, Adjuvant; Cisplatin; Dacarbazine; Dose-Response Relationship, Drug; Gene Expression Regulation, Neoplastic; Genetic Therapy; Glioma; HSP90 Heat-Shock Proteins; Humans; Inhibitory Concentration 50; RNA Interference; RNA, Messenger; RNA, Small Interfering; Temozolomide; Time Factors; Transfection | 2010 |
A small interference RNA screen revealed proteasome inhibition as strategy for glioblastoma therapy.
Topics: Animals; Antineoplastic Agents, Alkylating; Boronic Acids; Bortezomib; Brain Neoplasms; Cell Culture Techniques; Dacarbazine; Glioblastoma; Humans; Mice; Protease Inhibitors; Proteasome Endopeptidase Complex; Pyrazines; RNA Interference; RNA, Small Interfering; Temozolomide; Tumor Cells, Cultured | 2009 |
Far-distant metastases along the CSF pathway of glioblastoma multiforme during continuous low-dose chemotherapy with temozolomide and celecoxib.
Topics: Adult; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Brain Neoplasms; Celecoxib; Central Nervous System Neoplasms; Cerebrospinal Fluid; Combined Modality Therapy; Dacarbazine; Fatal Outcome; Female; Glioblastoma; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Pyrazoles; Sulfonamides; Survival; Temozolomide | 2010 |
Morphologic and molecular characterization of ATRT xenografts adapted for orthotopic therapeutic testing.
Topics: Animals; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Female; Glioblastoma; Humans; Infant; Male; Mice; Mice, Nude; Temozolomide; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2010 |
Therapy for recurrent high-grade gliomas: does continuous dose-intense temozolomide have a role?
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemotherapy, Adjuvant; Dacarbazine; Disease Progression; Disease-Free Survival; Glioma; Humans; Radiotherapy, Adjuvant; Recurrence; Temozolomide; Time Factors; Treatment Outcome | 2010 |
Bevacizumab is active as a single agent against recurrent malignant gliomas.
Topics: Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Brain Neoplasms; Dacarbazine; Doxorubicin; Female; Glioma; Humans; Lomustine; Male; Middle Aged; Neoplasm Invasiveness; Neoplasm Recurrence, Local; Neoplasm Staging; Procarbazine; Retrospective Studies; Survival Rate; Temozolomide; Treatment Outcome; Vincristine | 2010 |
MicroRNA-181 family predicts response to concomitant chemoradiotherapy with temozolomide in glioblastoma patients.
Topics: Adult; Aged; Biomarkers, Tumor; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Female; Glioblastoma; Humans; Male; MicroRNAs; Middle Aged; Promoter Regions, Genetic; Temozolomide; Tumor Suppressor Proteins | 2010 |
Survival of patients with newly diagnosed glioblastoma treated with radiation and temozolomide in research studies in the United States.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Benzodiazepines; Biomedical Research; Brain Neoplasms; Carboxymethylcellulose Sodium; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Combined Modality Therapy; Cranial Irradiation; Dacarbazine; Drug Therapy, Combination; Female; Glioblastoma; Humans; Interferon Inducers; Male; Middle Aged; Poly I-C; Polylysine; Receptors, AMPA; Snake Venoms; Survival Rate; Temozolomide; Treatment Outcome; United States; Young Adult | 2010 |
Changes of the O6-methylguanine-DNA methyltransferase promoter methylation and MGMT protein expression after adjuvant treatment in glioblastoma.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Biopsy; Brain Neoplasms; Cell Line, Tumor; Chemotherapy, Adjuvant; Cisplatin; Dacarbazine; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Female; Glioblastoma; Humans; Immunohistochemistry; Male; Microsurgery; Middle Aged; Neoplasm Recurrence, Local; Neurosurgical Procedures; Nimustine; Polymerase Chain Reaction; Promoter Regions, Genetic; Radiotherapy, Adjuvant; Reoperation; Temozolomide; Time Factors; Treatment Outcome; Tumor Suppressor Proteins | 2010 |
Inhibition of metalloproteinases derived from tumours: new insights in the treatment of human glioblastoma.
Topics: Antineoplastic Agents; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Chemotaxis; Dacarbazine; Drug Interactions; Glioblastoma; Humans; Hydroxamic Acids; Matrix Metalloproteinase 2; Matrix Metalloproteinase Inhibitors; Neoplasm Invasiveness; Sulfonamides; Temozolomide | 2010 |
Sensitivity to temozolomide in brain tumor initiating cells.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Survival; Dacarbazine; Glioblastoma; Humans; Temozolomide | 2010 |
The chemokine receptor CXCR7 is highly expressed in human glioma cells and mediates antiapoptotic effects.
Topics: Apoptosis; Apoptosis Regulatory Proteins; Brain Neoplasms; Camptothecin; Cell Movement; Cell Proliferation; Chemokine CXCL12; Dacarbazine; Enzyme Activation; Estrenes; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation, Neoplastic; Glioma; Humans; Pyrrolidinones; Receptors, CXCR; Temozolomide | 2010 |
Temozolomide/PLGA microparticles: a new protocol for treatment of glioma in rats.
Topics: Animals; Antineoplastic Agents; Apoptosis; Brain Neoplasms; Dacarbazine; Glioma; In Situ Nick-End Labeling; Lactic Acid; Microspheres; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Rats; Temozolomide | 2011 |
Pattern of failure after limited margin radiotherapy and temozolomide for glioblastoma.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Arsenic Trioxide; Arsenicals; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Disease Progression; Disease-Free Survival; Dose Fractionation, Radiation; Female; Follow-Up Studies; Glioblastoma; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Staging; Oxides; Radiotherapy Planning, Computer-Assisted; Temozolomide; Tomography, X-Ray Computed; Treatment Failure; Tumor Burden; Young Adult | 2011 |
Gene expression profiling predicts response to temozolomide in malignant gliomas.
Topics: Antineoplastic Agents, Alkylating; Blotting, Western; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Drug Resistance, Neoplasm; Gene Expression Profiling; Glioma; Humans; Inhibitory Concentration 50; Oligonucleotide Array Sequence Analysis; Prognosis; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Temozolomide; Tumor Suppressor Proteins | 2010 |
Prognostic value of MGMT promoter methylation in glioblastoma patients treated with temozolomide-based chemoradiation: a Portuguese multicentre study.
Topics: Antineoplastic Agents; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; DNA Methylation; Female; Glioblastoma; Humans; Male; Middle Aged; O(6)-Methylguanine-DNA Methyltransferase; Portugal; Promoter Regions, Genetic; Radiotherapy Dosage; Survival Rate; Temozolomide; Treatment Outcome | 2010 |
Intracerebral hemorrhage secondary to thrombocytopenia in a patient treated with temozolomide.
Topics: Adult; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cerebral Hemorrhage; Dacarbazine; Dose-Response Relationship, Drug; Fatal Outcome; Glioma; Humans; Male; Recurrence; Temozolomide; Thrombocytopenia | 2010 |
Effectiveness of temozolomide treatment used at the same time with radiotherapy and adjuvant temozolomide; concomitant therapy of glioblastoma multiforme: multivariate analysis and other prognostic factors.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemotherapy, Adjuvant; Combined Modality Therapy; Dacarbazine; Female; Glioblastoma; Humans; Male; Middle Aged; Multivariate Analysis; Prognosis; Retrospective Studies; Survival Analysis; Temozolomide; Treatment Outcome; Young Adult | 2010 |
Expression of CD74 in high grade gliomas: a potential role in temozolomide resistance.
Topics: Animals; Antigens, Differentiation, B-Lymphocyte; Antineoplastic Agents; Blotting, Western; Brain Neoplasms; Dacarbazine; Drug Resistance, Neoplasm; Gene Expression Profiling; Gene Knockdown Techniques; Glioma; Histocompatibility Antigens Class II; Humans; Immunohistochemistry; Mice; Mice, Nude; Reverse Transcriptase Polymerase Chain Reaction; Temozolomide; Transfection; Xenograft Model Antitumor Assays | 2010 |
Biodegradable carmustine wafers (Gliadel) alone or in combination with chemoradiotherapy: the French experience.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Biocompatible Materials; Brain Neoplasms; Carmustine; Clinical Trials, Phase III as Topic; Combined Modality Therapy; Dacarbazine; Decanoic Acids; Drug Carriers; Female; France; Glioma; Humans; Male; Middle Aged; Polyesters; Radiotherapy Dosage; Retrospective Studies; Survival Rate; Temozolomide; Treatment Outcome; Young Adult | 2010 |
Continuous low-dose temozolomide and celecoxib in recurrent glioblastoma.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Celecoxib; Cyclooxygenase 2 Inhibitors; Dacarbazine; Disease-Free Survival; DNA Modification Methylases; DNA Repair Enzymes; Female; Fluorine Radioisotopes; Follow-Up Studies; Glioblastoma; Humans; Male; Methylation; Middle Aged; Positron-Emission Tomography; Pyrazoles; Retrospective Studies; Sulfonamides; Temozolomide; Tumor Suppressor Proteins; Tyrosine | 2010 |
Minimally cytotoxic doses of temozolomide produce radiosensitization in human glioblastoma cells regardless of MGMT expression.
Topics: Adult; Antineoplastic Agents; Brain Neoplasms; Dacarbazine; DNA Mismatch Repair; DNA Modification Methylases; DNA Repair Enzymes; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Gamma Rays; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Maximum Tolerated Dose; Radiation Tolerance; Temozolomide; Tumor Cells, Cultured; Tumor Suppressor Proteins | 2010 |
Nitrosourea-based chemotherapy for low grade gliomas failing initial treatment with temozolomide.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Disease-Free Survival; Female; Glioma; Humans; Karnofsky Performance Status; Male; Middle Aged; Nitrosourea Compounds; Retrospective Studies; Temozolomide; Treatment Outcome | 2010 |
Evaluation of diffusion parameters as early biomarkers of disease progression in glioblastoma multiforme.
Topics: Antineoplastic Agents; Biomarkers, Tumor; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Diffusion Tensor Imaging; Disease Progression; Disease-Free Survival; Glioblastoma; Humans; Prognosis; Radiotherapy; Temozolomide | 2010 |
Preoperative chemotherapy for infiltrative low-grade oligoastrocytoma: a useful strategy to maximize surgical resection -case report-.
Topics: Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Chemotherapy, Adjuvant; Corpus Callosum; Dacarbazine; Female; Frontal Lobe; Functional Laterality; Humans; Motor Cortex; Neoadjuvant Therapy; Preoperative Period; Temozolomide; Treatment Outcome | 2010 |
Efficient delivery of liposome-mediated MGMT-siRNA reinforces the cytotoxity of temozolomide in GBM-initiating cells.
Topics: Animals; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Line, Tumor; Combined Modality Therapy; Dacarbazine; DNA Repair; Drug Delivery Systems; Glioblastoma; Liposomes; Mice; Mice, Inbred NOD; Mice, SCID; O(6)-Methylguanine-DNA Methyltransferase; RNA, Small Interfering; Temozolomide | 2010 |
Initial experience involving treatment and retreatment with carmustine wafers in combination with oral temozolomide: long-term survival in a child with relapsed glioblastoma multiforme.
Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carmustine; Child; Combined Modality Therapy; Craniotomy; Dacarbazine; Glioblastoma; Humans; Magnetic Resonance Imaging; Retreatment; Temozolomide; Treatment Outcome | 2010 |
Embryonic stem cell (ESC)-mediated transgene delivery induces growth suppression, apoptosis and radiosensitization, and overcomes temozolomide resistance in malignant gliomas.
Topics: Animals; Antineoplastic Agents, Alkylating; Apoptosis; Blotting, Western; Brain Neoplasms; Cell Proliferation; Cells, Cultured; Combined Modality Therapy; Dacarbazine; Drug Delivery Systems; Drug Resistance, Neoplasm; Embryonic Stem Cells; Enzyme-Linked Immunosorbent Assay; Female; Gene Transfer Techniques; Genetic Therapy; Genetic Vectors; Glioma; Humans; Immunoenzyme Techniques; Interleukins; Mice; Mice, Nude; Radiation-Sensitizing Agents; Radiation, Ionizing; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Temozolomide; Transgenes; Tumor Stem Cell Assay | 2010 |
Changes in relative cerebral blood volume 1 month after radiation-temozolomide therapy can help predict overall survival in patients with glioblastoma.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Blood Volume; Brain Neoplasms; Dacarbazine; Female; Glioblastoma; Humans; Incidence; Magnetic Resonance Imaging; Male; Middle Aged; Radiotherapy, Conformal; Survival Analysis; Survival Rate; Temozolomide; Treatment Outcome | 2010 |
PTEN loss compromises homologous recombination repair in astrocytes: implications for glioblastoma therapy with temozolomide or poly(ADP-ribose) polymerase inhibitors.
Topics: Animals; Antineoplastic Agents, Alkylating; Astrocytes; Benzimidazoles; Brain Neoplasms; Cyclin-Dependent Kinase Inhibitor p16; Dacarbazine; DNA Damage; DNA Repair; Glioblastoma; Methylnitronitrosoguanidine; Mice; Mice, Transgenic; Poly(ADP-ribose) Polymerase Inhibitors; PTEN Phosphohydrolase; Recombination, Genetic; Temozolomide | 2010 |
Temozolomide (Temodar).
Topics: Administration, Oral; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Dacarbazine; Drug Costs; Glioblastoma; Humans; Temozolomide | 2010 |
High-grade malignant glioma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up.
Topics: Adrenal Cortex Hormones; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Europe; Follow-Up Studies; Genetic Markers; Glioma; Humans; Incidence; Loss of Heterozygosity; Neoplasm Staging; Prognosis; Radiotherapy; Randomized Controlled Trials as Topic; Risk Assessment; Secondary Prevention; Temozolomide; Treatment Outcome | 2010 |
Up-front temozolomide in elderly patients with anaplastic oligodendroglioma and oligoastrocytoma.
Topics: Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; DNA, Neoplasm; Female; Follow-Up Studies; Humans; Male; Oligodendroglioma; Polymerase Chain Reaction; Promoter Regions, Genetic; Retrospective Studies; Survival Rate; Temozolomide; Treatment Outcome; Tumor Suppressor Proteins | 2011 |
MGMT gene promoter methylation in pediatric glioblastomas.
Topics: Adolescent; Antineoplastic Agents, Alkylating; Brain Neoplasms; Child; Child, Preschool; Dacarbazine; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Female; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Immunoenzyme Techniques; Infant; Male; Polymerase Chain Reaction; Prognosis; Promoter Regions, Genetic; Temozolomide; Tumor Suppressor Protein p53; Tumor Suppressor Proteins | 2010 |
Effect of aberrant p53 function on temozolomide sensitivity of glioma cell lines and brain tumor initiating cells from glioblastoma.
Topics: Antineoplastic Agents, Alkylating; Blotting, Western; Brain Neoplasms; Dacarbazine; DNA Methylation; Drug Resistance, Neoplasm; Glioma; Humans; Mutation; Neoplastic Stem Cells; O(6)-Methylguanine-DNA Methyltransferase; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Small Interfering; Temozolomide; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2011 |
Rash in four patients with brain tumor-related epilepsy in monotherapy with oxcarbazepine, during radiotherapy.
Topics: Anticonvulsants; Antineoplastic Agents; Brain Neoplasms; Carbamazepine; Combined Modality Therapy; Cranial Irradiation; Dacarbazine; Epilepsy; Exanthema; Female; Humans; Male; Middle Aged; Oxcarbazepine; Radiotherapy; Temozolomide | 2010 |
Convection-enhanced delivery of a synthetic retinoid Am80, loaded into polymeric micelles, prolongs the survival of rats bearing intracranial glioblastoma xenografts.
Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Apoptosis; Benzoates; Brain Neoplasms; Cell Survival; Convection; Dacarbazine; Drug Delivery Systems; Glioblastoma; Humans; Longevity; Male; Micelles; Polymers; Rats; Rats, Inbred F344; Rats, Nude; Rats, Sprague-Dawley; Retinoids; Temozolomide; Tetrahydronaphthalenes; Xenograft Model Antitumor Assays | 2010 |
Influence of iMRI-guidance on the extent of resection and survival of patients with glioblastoma multiforme.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Female; Glioblastoma; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Monitoring, Intraoperative; Neurosurgical Procedures; Prospective Studies; Retrospective Studies; Surgery, Computer-Assisted; Survival Rate; Temozolomide; Treatment Outcome | 2010 |
Radiation induced early necrosis in patients with malignant gliomas receiving temozolomide.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Disease-Free Survival; Female; Glioma; Humans; Kaplan-Meier Estimate; Magnetic Resonance Spectroscopy; Male; Middle Aged; Necrosis; Radiation Injuries; Radiotherapy; Retrospective Studies; Temozolomide; Young Adult | 2010 |
Effect of alternative temozolomide schedules on glioblastoma O(6)-methylguanine-DNA methyltransferase activity and survival.
Topics: Animals; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; Dose-Response Relationship, Drug; Glioblastoma; Humans; O(6)-Methylguanine-DNA Methyltransferase; Rats; Survival Analysis; Temozolomide; Tumor Burden | 2010 |
Pseudoprogression in patients with malignant gliomas treated with concurrent temozolomide and radiotherapy: potential role of p53.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Disease Progression; Female; Follow-Up Studies; Glioma; Humans; Immunoenzyme Techniques; Incidence; Magnetic Resonance Imaging; Male; Middle Aged; Radiotherapy, Adjuvant; Survival Rate; Temozolomide; Treatment Outcome; Tumor Suppressor Protein p53; Young Adult | 2011 |
MiR-21 protected human glioblastoma U87MG cells from chemotherapeutic drug temozolomide induced apoptosis by decreasing Bax/Bcl-2 ratio and caspase-3 activity.
Topics: Antineoplastic Agents, Alkylating; Apoptosis; bcl-2-Associated X Protein; Brain Neoplasms; Caspase 3; Cell Division; Cell Line, Tumor; Dacarbazine; Flow Cytometry; Glioblastoma; Glioma; Humans; MicroRNAs; Proto-Oncogene Proteins c-bcl-2; Temozolomide | 2010 |
A pilot study of hypofractionated radiation therapy with temozolomide for adults with glioblastoma multiforme.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Disease Progression; Dose Fractionation, Radiation; Female; Glioblastoma; Humans; Male; Middle Aged; Pilot Projects; Prospective Studies; Quality of Life; Survival Rate; Temozolomide; Treatment Outcome | 2011 |
Patterns of care and survival in a retrospective analysis of 1059 patients with glioblastoma multiforme treated between 2002 and 2007: a multicenter study by the Central Nervous System Study Group of Airo (italian Association of Radiation Oncology).
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Analysis of Variance; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Databases, Factual; Female; Glioblastoma; Humans; Italy; Kaplan-Meier Estimate; Karnofsky Performance Status; Male; Middle Aged; Neurosurgical Procedures; Patient Care; Radiotherapy; Retrospective Studies; Salvage Therapy; Survival Analysis; Temozolomide; Treatment Outcome; Young Adult | 2010 |
Prognostic value of early [18F]fluoroethyltyrosine positron emission tomography after radiochemotherapy in glioblastoma multiforme.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Disease-Free Survival; Female; Glioblastoma; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Positron-Emission Tomography; Prognosis; Prospective Studies; Radiopharmaceuticals; Temozolomide; Tyrosine | 2011 |
Combination of 6-thioguanine, capecitabine, and celecoxib with temozolomide or lomustine for recurrent high-grade glioma.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Capecitabine; Celecoxib; Dacarbazine; Deoxycytidine; Female; Fluorouracil; Glioblastoma; Gliosarcoma; Humans; Lomustine; Magnetic Resonance Imaging; Male; Middle Aged; Neoplasm Recurrence, Local; Prospective Studies; Pyrazoles; Sulfonamides; Survival Rate; Temozolomide; Thioguanine; Treatment Outcome; Young Adult | 2011 |
Temozolomide, quercetin and cell death in the MOGGCCM astrocytoma cell line.
Topics: Apoptosis; Astrocytoma; Blotting, Western; Brain Neoplasms; Cell Death; Cell Line, Tumor; Dacarbazine; Fluorescent Antibody Technique, Indirect; Humans; Quercetin; Temozolomide | 2010 |
Acute lymphoblastic leukemia after temozolomide treatment for anaplastic astrocytoma in a child with a germline TP53 mutation.
Topics: Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Child; Dacarbazine; Female; Frontal Lobe; Genes, p53; Germ-Line Mutation; Humans; Neoplasms, Second Primary; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Temozolomide | 2010 |
Long-term outcomes in children with glioblastoma.
Topics: Adolescent; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemotherapy, Adjuvant; Child; Child, Preschool; Combined Modality Therapy; Dacarbazine; Female; Glioblastoma; Humans; Infant; Male; Neoplasm Recurrence, Local; Radiosurgery; Radiotherapy, Adjuvant; Reoperation; Republic of Korea; Retrospective Studies; Survival Rate; Temozolomide | 2010 |
Kitten-transmitted Bordetella bronchiseptica infection in a patient receiving temozolomide for glioblastoma.
Topics: Animals; Antineoplastic Agents, Alkylating; Bordetella bronchiseptica; Bordetella Infections; Brain Neoplasms; Cats; Chemotherapy, Adjuvant; Combined Modality Therapy; Dacarbazine; Glioblastoma; Humans; Immunocompromised Host; Male; Middle Aged; Prognosis; Radiotherapy Dosage; Respiratory Tract Infections; Temozolomide; Zoonoses | 2011 |
[Side effects of temozolomide treatment in patient with glioblastoma multiforme--case study].
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemotherapy, Adjuvant; Dacarbazine; Female; Glioblastoma; Humans; Middle Aged; Nervous System Diseases; Pancytopenia; Radiotherapy, Adjuvant; Temozolomide | 2010 |
Correlation between O6-methylguanine-DNA methyltransferase and survival in elderly patients with glioblastoma treated with radiotherapy plus concomitant and adjuvant temozolomide.
Topics: Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; DNA, Neoplasm; Epigenomics; Female; Glioblastoma; Humans; Male; Polymerase Chain Reaction; Promoter Regions, Genetic; Radiotherapy Dosage; Survival Rate; Temozolomide; Treatment Outcome; Tumor Suppressor Proteins | 2011 |
First-line treatment of malignant glioma with carmustine implants followed by concomitant radiochemotherapy: a multicenter experience.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Carmustine; Combined Modality Therapy; Dacarbazine; Disease-Free Survival; Drug Implants; Female; Glioblastoma; Humans; Karnofsky Performance Status; Male; Middle Aged; Nervous System Diseases; Risk Factors; Survival Analysis; Temozolomide; Treatment Outcome | 2010 |
Hepatic encephalopathy after treatment with temozolomide.
Topics: Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Female; Glioblastoma; Hepatic Encephalopathy; Humans; Temozolomide; Treatment Outcome | 2011 |
Favorable prognosis in patients with high-grade glioma with radiation necrosis: the University of Colorado reoperation series.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Carmustine; Colorado; Combined Modality Therapy; Dacarbazine; Female; Glioblastoma; Humans; Linear Models; Male; Middle Aged; Necrosis; Neoplasm Recurrence, Local; Proportional Hazards Models; Radiotherapy Dosage; Reoperation; Retreatment; Salvage Therapy; Temozolomide; Time Factors; Young Adult | 2011 |
Gamma-secretase inhibitors enhance temozolomide treatment of human gliomas by inhibiting neurosphere repopulation and xenograft recurrence.
Topics: Amyloid Precursor Protein Secretases; Animals; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; Dipeptides; Glioblastoma; Humans; Mice; Neoplasm Recurrence, Local; Receptors, Notch; RNA, Messenger; Signal Transduction; Spheroids, Cellular; Temozolomide; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2010 |
Combination of temozolomide with immunocytokine F16-IL2 for the treatment of glioblastoma.
Topics: Animals; Antineoplastic Agents; Apoptosis; Brain Neoplasms; Cell Proliferation; Dacarbazine; Glioblastoma; Humans; Immunohistochemistry; Interleukin-2; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Temozolomide; Tissue Distribution | 2010 |
Aplastic anemia as a cause of death in a patient with glioblastoma multiforme treated with temozolomide.
Topics: Anemia, Aplastic; Antineoplastic Agents, Alkylating; Blood Cell Count; Brain Neoplasms; Cause of Death; Combined Modality Therapy; Cranial Irradiation; Dacarbazine; Dose Fractionation, Radiation; Female; Frontal Lobe; Glioblastoma; Hemorrhagic Disorders; Humans; Magnetic Resonance Imaging; Middle Aged; Parietal Lobe; Temozolomide | 2010 |
Low peripheral lymphocyte count before focal radiotherapy plus concomitant temozolomide predicts severe lymphopenia during malignant glioma treatment.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemotherapy, Adjuvant; Combined Modality Therapy; Dacarbazine; Female; Glioma; Humans; Lymphocyte Count; Lymphopenia; Male; Middle Aged; Predictive Value of Tests; Radiotherapy, Adjuvant; Severity of Illness Index; Statistics, Nonparametric; Temozolomide | 2010 |
Brain metastasis of undifferentiated sarcoma and response to temozolomide treatment. Case report.
Topics: Adult; Antineoplastic Agents, Alkylating; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; Female; Gene Silencing; Humans; Neoplasm Recurrence, Local; Salvage Therapy; Sarcoma; Soft Tissue Neoplasms; Temozolomide; Tumor Suppressor Proteins | 2010 |
In vitro novel combinations of psychotropics and anti-cancer modalities in U87 human glioblastoma cells.
Topics: Adenosine Triphosphate; Antineoplastic Combined Chemotherapy Protocols; Benzamides; Brain Neoplasms; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Dacarbazine; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Down-Regulation; Drug Synergism; Glioblastoma; Humans; Imatinib Mesylate; Mitogen-Activated Protein Kinases; Phenothiazines; Phosphorylation; Piperazines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Psychotropic Drugs; Pyrimidines; Selective Serotonin Reuptake Inhibitors; Temozolomide | 2010 |
Feasibility study of 21-day-on/7-day-off temozolomide in children with brain tumors.
Topics: Adolescent; Antineoplastic Agents, Alkylating; Brain Neoplasms; Child; Child, Preschool; Dacarbazine; Disease Progression; Drug Administration Schedule; Feasibility Studies; Female; Follow-Up Studies; Glioma; Humans; Infant; Male; Neoplasm Recurrence, Local; Survival Rate; Temozolomide; Treatment Outcome | 2011 |
Temozolomide/PLGA microparticles plus vatalanib inhibits tumor growth and angiogenesis in an orthotopic glioma model.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Dacarbazine; Disease Models, Animal; Drug Delivery Systems; Glioma; Humans; Lactic Acid; Male; Neovascularization, Pathologic; Phthalazines; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Pyridines; Rats; Rats, Sprague-Dawley; Temozolomide; Treatment Outcome | 2010 |
Long-term in vitro treatment of human glioblastoma cells with temozolomide increases resistance in vivo through up-regulation of GLUT transporter and aldo-keto reductase enzyme AKR1C expression.
Topics: Alcohol Oxidoreductases; Aldehyde Reductase; Aldo-Keto Reductases; Animals; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Culture Techniques; Cell Line, Tumor; Dacarbazine; Drug Resistance, Neoplasm; Female; Gene Expression Regulation, Neoplastic; Glioblastoma; Glucose Transport Proteins, Facilitative; HT29 Cells; Humans; Mice; Mice, Nude; Temozolomide; Time Factors; Up-Regulation; Xenograft Model Antitumor Assays | 2010 |
Correlation of MRI sequences to assess progressive glioblastoma multiforme treated with bevacizumab.
Topics: Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Brain Neoplasms; Camptothecin; Carboplatin; Dacarbazine; Disease Progression; Female; Glioblastoma; Humans; Irinotecan; Magnetic Resonance Imaging; Male; Middle Aged; Temozolomide | 2011 |
Postoperative radiotherapy and concomitant temozolomide for elderly patients with glioblastoma.
Topics: Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemotherapy, Adjuvant; Combined Modality Therapy; Dacarbazine; Disease-Free Survival; Glioblastoma; Humans; Male; Prognosis; Radiotherapy, Adjuvant; Survival Rate; Temozolomide | 2010 |
Patterns of failure and comparison of different target volume delineations in patients with glioblastoma treated with conformal radiotherapy plus concomitant and adjuvant temozolomide.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemotherapy, Adjuvant; Combined Modality Therapy; Dacarbazine; Disease-Free Survival; Female; Glioblastoma; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Neoplasm Recurrence, Local; Radiotherapy Dosage; Radiotherapy Planning, Computer-Assisted; Radiotherapy, Conformal; Survival Rate; Temozolomide; Tomography, X-Ray Computed | 2010 |
Quantitative analysis of O6-methylguanine DNA methyltransferase (MGMT) promoter methylation in patients with low-grade gliomas.
Topics: Adult; Aged; Antineoplastic Agents; Brain Neoplasms; Dacarbazine; Disease-Free Survival; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Drug Resistance, Neoplasm; Female; Glioma; Humans; Kaplan-Meier Estimate; Loss of Heterozygosity; Male; Middle Aged; Promoter Regions, Genetic; Retrospective Studies; Reverse Transcriptase Polymerase Chain Reaction; Temozolomide; Tumor Suppressor Proteins | 2011 |
Predominant influence of MGMT methylation in non-resectable glioblastoma after radiotherapy plus temozolomide.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Disease-Free Survival; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Female; Glioblastoma; Humans; Male; Middle Aged; Prognosis; Promoter Regions, Genetic; Prospective Studies; Sequence Analysis; Stereotaxic Techniques; Survival Analysis; Temozolomide; Tumor Suppressor Proteins | 2011 |
Temozolomide during and after radiation therapy for WHO grade III gliomas: preliminary report of a prospective multicenter study.
Topics: Adolescent; Adult; Antineoplastic Agents, Alkylating; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Female; Glioma; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Probability; Prospective Studies; Retrospective Studies; Temozolomide; Time Factors; Young Adult | 2011 |
Urticarial hypersensitivity reaction caused by temozolomide.
Topics: Adult; Anti-Inflammatory Agents; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Dacarbazine; Drug Eruptions; Eosinophils; Fluocinonide; Histamine H1 Antagonists; Humans; Male; Skin; Temozolomide; Urticaria | 2010 |
Leptomeningeal metastases from small cell lung cancer responsive to temozolomide therapy.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Female; Humans; Lung Neoplasms; Male; Meningeal Neoplasms; Middle Aged; Small Cell Lung Carcinoma; Temozolomide; Treatment Outcome | 2010 |
Malignant melanoma of the breast: N-isopropyl-p-(123) I-iodoamphetamine single photon emission computed tomography ((123) I-IMP SPECT) is useful for the detection of metastasis.
Topics: Adrenal Gland Neoplasms; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Breast Neoplasms; Cisplatin; Dacarbazine; Fatal Outcome; Female; Humans; Interferon-beta; Iofetamine; Liver Neoplasms; Lung Neoplasms; MART-1 Antigen; Mastectomy, Modified Radical; Melanoma; Middle Aged; Neoplasm Staging; Nimustine; Nipples; Radiopharmaceuticals; S100 Proteins; Skin Neoplasms; Tamoxifen; Tomography, Emission-Computed, Single-Photon; Vincristine | 2010 |
High-field iMRI in glioblastoma surgery: improvement of resection radicality and survival for the patient?
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Diffusion Magnetic Resonance Imaging; Female; Follow-Up Studies; Glioblastoma; Humans; Karnofsky Performance Status; Magnetic Resonance Imaging; Male; Monitoring, Intraoperative; Neurosurgical Procedures; Retrospective Studies; Temozolomide | 2011 |
IDH1 or IDH2 mutations predict longer survival and response to temozolomide in low-grade gliomas.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chi-Square Distribution; Dacarbazine; Disease-Free Survival; DNA Methylation; DNA Modification Methylases; DNA Mutational Analysis; DNA Repair Enzymes; Female; Glioma; Humans; Isocitrate Dehydrogenase; Loss of Heterozygosity; Male; Middle Aged; Mutation; Pharmacogenetics; Predictive Value of Tests; Retrospective Studies; Statistics as Topic; Temozolomide; Tumor Suppressor Proteins; Young Adult | 2010 |
What role should cilengitide have in the treatment of glioblastoma?
Topics: Brain Neoplasms; Clinical Trials as Topic; Dacarbazine; Glioblastoma; Humans; Snake Venoms; Temozolomide | 2010 |
Irradiation and bevacizumab in high-grade glioma retreatment settings.
Topics: Adolescent; Adult; Aged; Analysis of Variance; Angiogenesis Inhibitors; Antibodies, Monoclonal, Humanized; Antineoplastic Agents, Alkylating; Bevacizumab; Brain Neoplasms; Chemoradiotherapy; Dacarbazine; Feasibility Studies; Female; Glioma; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Radiotherapy Dosage; Retreatment; Retrospective Studies; Survival Analysis; Temozolomide; Vascular Endothelial Growth Factor A; Young Adult | 2012 |
Assessment of perfusion MRI-derived parameters in evaluating and predicting response to antiangiogenic therapy in patients with newly diagnosed glioblastoma.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemotherapy, Adjuvant; Combined Modality Therapy; Dacarbazine; Disease Progression; Glioblastoma; Humans; Image Processing, Computer-Assisted; Indoles; Magnetic Resonance Imaging; Perfusion; Radiotherapy, Adjuvant; Survival Rate; Temozolomide; Treatment Outcome | 2011 |
MGMT promoter methylation in pediatric high-grade gliomas.
Topics: Antineoplastic Agents; Brain Neoplasms; Child; Combined Modality Therapy; Dacarbazine; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Drug Resistance, Neoplasm; Female; Glioma; Humans; Male; Neurosurgical Procedures; Promoter Regions, Genetic; Radiotherapy; Temozolomide; Treatment Outcome; Tumor Suppressor Proteins | 2011 |
Fractionated stereotactic reirradiation and concurrent temozolomide in patients with recurrent glioblastoma.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Disease-Free Survival; DNA Modification Methylases; DNA Repair Enzymes; Female; Glioblastoma; Humans; Karnofsky Performance Status; Magnetic Resonance Imaging; Male; Middle Aged; Neoplasm Recurrence, Local; Retrospective Studies; Stereotaxic Techniques; Temozolomide; Treatment Outcome; Tumor Suppressor Proteins | 2011 |
Radiographic patterns of relapse in glioblastoma.
Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Female; Glioblastoma; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Neoplasm Recurrence, Local; Radiography; Retrospective Studies; Salvage Therapy; Temozolomide; Time Factors; Treatment Outcome; Young Adult | 2011 |
Clinical significance of molecular biomarkers in glioblastoma.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Biomarkers; Brain Neoplasms; Cyclin-Dependent Kinase Inhibitor p16; Dacarbazine; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; ErbB Receptors; Female; Follow-Up Studies; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Neoplasm Proteins; PTEN Phosphohydrolase; Regression Analysis; Retrospective Studies; Temozolomide; Tumor Suppressor Protein p53; Tumor Suppressor Proteins; Young Adult | 2010 |
Usefulness of MS-MLPA for detection of MGMT promoter methylation in the evaluation of pseudoprogression in glioblastoma patients.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Disease Progression; DNA Methylation; Female; Glioblastoma; Humans; Immunoenzyme Techniques; Male; Middle Aged; Molecular Probe Techniques; Nucleic Acid Amplification Techniques; O(6)-Methylguanine-DNA Methyltransferase; Polymerase Chain Reaction; Promoter Regions, Genetic; Radiotherapy Dosage; Survival Rate; Temozolomide; Treatment Outcome | 2011 |
Neuro-oncology, a decade of temozolomide and beyond.
Topics: Antineoplastic Agents; Brain Neoplasms; Dacarbazine; Humans; Quality of Life; Temozolomide; Treatment Outcome | 2010 |
Synergistic therapeutic effects of cytokine-induced killer cells and temozolomide against glioblastoma.
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Combined Modality Therapy; Cytokine-Induced Killer Cells; Dacarbazine; Glioblastoma; Humans; Immunotherapy, Adoptive; Mice; Mice, Nude; Temozolomide; Xenograft Model Antitumor Assays | 2011 |
Advances in translational research provide a rationale for clinical re-evaluation of high-dose radiotherapy for glioblastoma.
Topics: Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Clinical Trials as Topic; Dacarbazine; Dose Fractionation, Radiation; Dose-Response Relationship, Radiation; Glioblastoma; Humans; Radiotherapy Dosage; Radiotherapy, Conformal; Temozolomide; Translational Research, Biomedical | 2011 |
Taming glioblastoma by targeting angiogenesis: 3 years later.
Topics: Angiogenesis Inhibitors; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Brain Neoplasms; Clinical Trials, Phase II as Topic; Dacarbazine; Glioblastoma; Humans; Neovascularization, Pathologic; Temozolomide | 2011 |
Non-stem cell origin for oligodendroglioma.
Topics: Animals; Antigens; Benzamides; Brain Neoplasms; Cell Differentiation; Cell Line, Tumor; Dacarbazine; Diphenylamine; Humans; Mice; Mitogen-Activated Protein Kinases; Neural Stem Cells; Oligodendroglia; Oligodendroglioma; Oncogene Proteins v-erbB; Proteoglycans; Temozolomide; Tumor Suppressor Protein p53 | 2010 |
First-line temozolomide chemotherapy in progressive low-grade astrocytomas after radiotherapy: molecular characteristics in relation to response.
Topics: Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Biomarkers, Tumor; Brain Neoplasms; Chromosome Deletion; Chromosomes, Human, Pair 1; Chromosomes, Human, Pair 19; Dacarbazine; DNA Methylation; DNA, Neoplasm; Female; Follow-Up Studies; Humans; Immunoenzyme Techniques; Isocitrate Dehydrogenase; Male; Middle Aged; Mutation; Neoplasm Staging; O(6)-Methylguanine-DNA Methyltransferase; Polymerase Chain Reaction; Promoter Regions, Genetic; Radiotherapy Dosage; Survival Rate; Temozolomide; Treatment Outcome; Trisomy; Tumor Suppressor Protein p53 | 2011 |
Radiotherapy and temozolomide for newly diagnosed glioblastoma and anaplastic astrocytoma: validation of Radiation Therapy Oncology Group-Recursive Partitioning Analysis in the IMRT and temozolomide era.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Chi-Square Distribution; Combined Modality Therapy; Dacarbazine; Dose Fractionation, Radiation; Female; Glioblastoma; Humans; Karnofsky Performance Status; Male; Middle Aged; Radiotherapy; Radiotherapy, Intensity-Modulated; Regression Analysis; Reproducibility of Results; Retrospective Studies; Temozolomide | 2011 |
Case of atypical teratoid/rhabdoid tumor in an adult, with long survival.
Topics: Adult; Biomarkers, Tumor; Brain Neoplasms; Chromosomal Proteins, Non-Histone; Combined Modality Therapy; Dacarbazine; Disease-Free Survival; DNA Modification Methylases; DNA Repair Enzymes; DNA-Binding Proteins; Female; Humans; Immunohistochemistry; Neoplasm Recurrence, Local; Neurosurgical Procedures; Parietal Lobe; Rhabdoid Tumor; SMARCB1 Protein; Temozolomide; Teratoma; Time Factors; Transcription Factors; Tumor Suppressor Proteins | 2011 |
Intracranial microcapsule drug delivery device for the treatment of an experimental gliosarcoma model.
Topics: Animals; Brain; Brain Neoplasms; Capsules; Dacarbazine; Disease Models, Animal; Drug Delivery Systems; Gliosarcoma; Immunohistochemistry; In Situ Nick-End Labeling; Kinetics; Rats; Rats, Inbred F344; Temozolomide | 2011 |
A combined preclinical therapy of cannabinoids and temozolomide against glioma.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Autophagy; Brain Neoplasms; Cell Growth Processes; Cell Line, Tumor; Cell Survival; Dacarbazine; Dronabinol; Drug Resistance, Neoplasm; Drug Synergism; Glioblastoma; Humans; Mice; Mice, Nude; Random Allocation; Temozolomide; Transfection; Xenograft Model Antitumor Assays | 2011 |
Dural venous sinus thrombosis in anaplastic astrocytoma following concurrent temozolomide and focal brain radiotherapy plus bevacizumab.
Topics: Adult; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Bevacizumab; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Dura Mater; Female; Humans; Radiotherapy; Sinus Thrombosis, Intracranial; Temozolomide | 2011 |
Impact of temozolomide chemotherapy on seizure frequency in patients with low-grade gliomas.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chi-Square Distribution; Dacarbazine; Female; Glioma; Humans; Male; Middle Aged; Seizures; Temozolomide; Treatment Outcome | 2011 |
Lonafarnib (SCH66336) improves the activity of temozolomide and radiation for orthotopic malignant gliomas.
Topics: Animals; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Dacarbazine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Glioma; Humans; Mice; Neoplasm Transplantation; Piperidines; Prenylation; Pyridines; Radiation, Ionizing; ras Proteins; Signal Transduction; Temozolomide; Time Factors | 2011 |
Green tea epigallocatechin gallate enhances therapeutic efficacy of temozolomide in orthotopic mouse glioblastoma models.
Topics: Animals; Antineoplastic Agents, Alkylating; Brain Neoplasms; Camellia sinensis; Catechin; Cell Line, Tumor; Dacarbazine; Disease Models, Animal; Drug Synergism; Endoplasmic Reticulum Chaperone BiP; Glioblastoma; Humans; Immunohistochemistry; Mice; Mice, Knockout; Temozolomide | 2011 |
Induction of autophagy in temozolomide treated malignant gliomas.
Topics: Adolescent; Adult; Aged; Autophagy; Brain Neoplasms; Child; Child, Preschool; Dacarbazine; Female; Glioma; Humans; Infant; Male; Middle Aged; Temozolomide; Treatment Outcome; Young Adult | 2011 |
Clinical features, management and outcomes of high-grade glioma patients in Ramathibodi Hospital.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Carmustine; Combined Modality Therapy; Dacarbazine; Disease-Free Survival; Female; Follow-Up Studies; Glioma; Hospitals; Humans; Incidence; Male; Middle Aged; Prognosis; Proportional Hazards Models; Retrospective Studies; Survival Analysis; Temozolomide; Treatment Outcome; Young Adult | 2010 |
Retrospective comparison of chemoradiotherapy followed by adjuvant chemotherapy, with or without prior gliadel implantation (carmustine) after initial surgery in patients with newly diagnosed high-grade gliomas.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Carmustine; Chemoradiotherapy; Chemotherapy, Adjuvant; Dacarbazine; Disease-Free Survival; DNA Modification Methylases; DNA Repair Enzymes; Female; Glioblastoma; Humans; Male; Middle Aged; Neoplasm Proteins; Retrospective Studies; Survival Analysis; Temozolomide; Thrombocytopenia; Tumor Burden; Tumor Suppressor Proteins; Young Adult | 2012 |
Prognostic factors for patients with gliomatosis cerebri: retrospective analysis of 17 consecutive cases.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Biopsy; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Fatal Outcome; Female; Humans; Immunohistochemistry; Kaplan-Meier Estimate; Ki-67 Antigen; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Neoplasms, Neuroepithelial; Neurosurgical Procedures; Nimustine; O(6)-Methylguanine-DNA Methyltransferase; Prognosis; Retrospective Studies; Temozolomide; Tumor Suppressor Protein p53; Young Adult | 2010 |
Inhibition of PI3K/mTOR pathways in glioblastoma and implications for combination therapy with temozolomide.
Topics: Animals; Antineoplastic Agents, Alkylating; Blotting, Western; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Dacarbazine; Drug Synergism; Drug Therapy, Combination; Enzyme Inhibitors; Glioblastoma; Humans; Immunoenzyme Techniques; Mice; Mice, Nude; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Survival Rate; Temozolomide; TOR Serine-Threonine Kinases; Xenograft Model Antitumor Assays | 2011 |
TMZ-induced PrPc/par-4 interaction promotes the survival of human glioma cells.
Topics: Animals; Antineoplastic Agents, Alkylating; Apoptosis; Brain Neoplasms; Cell Cycle; Cell Line, Tumor; Cyclic AMP-Dependent Protein Kinases; Dacarbazine; Drug Resistance, Neoplasm; Female; Glioma; Humans; Mice; Mice, Inbred NOD; Mice, SCID; Phosphorylation; PrPC Proteins; Receptors, Thrombin; RNA, Small Interfering; Temozolomide; Transfection | 2012 |
GRP78/BiP modulation of GRP78/BiP in altering sensitivity to chemotherapy.
Topics: Activating Transcription Factor 6; Animals; Antineoplastic Agents; Brain Neoplasms; Catechin; Cell Line, Tumor; Cells, Cultured; Cytological Techniques; Dacarbazine; Endoplasmic Reticulum Chaperone BiP; Gene Expression Regulation, Neoplastic; Glioma; Heat-Shock Proteins; Humans; Immunohistochemistry; Mice; Rats; Temozolomide | 2011 |
O6-methylguanine DNA methyltransferase expression in tumor cells predicts outcome of radiotherapy plus concomitant and adjuvant temozolomide therapy in patients with primary glioblastoma.
Topics: Adult; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Brain Neoplasms; Cell Line, Tumor; Combined Modality Therapy; Dacarbazine; Disease-Free Survival; Female; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Male; Middle Aged; O(6)-Methylguanine-DNA Methyltransferase; Retrospective Studies; Temozolomide; Treatment Outcome | 2011 |
Immune modulation effects of concomitant temozolomide and radiation therapy on peripheral blood mononuclear cells in patients with glioblastoma multiforme.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Blood Cells; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Dendritic Cells; Female; Flow Cytometry; Glioblastoma; Humans; Lymphocyte Subsets; Male; Middle Aged; Prognosis; Radiotherapy Dosage; T-Lymphocytes, Regulatory; Temozolomide; Young Adult | 2011 |
Neural stem/progenitors and glioma stem-like cells have differential sensitivity to chemotherapy.
Topics: Animals; Antineoplastic Agents; Apoptosis; Boronic Acids; Bortezomib; Brain Neoplasms; Caspase 3; Cell Line, Tumor; Cell Proliferation; Cells, Cultured; Cisplatin; Dacarbazine; Drug Resistance, Neoplasm; ErbB Receptors; Erlotinib Hydrochloride; Gene Expression; Glioma; Humans; Neoplastic Stem Cells; Neural Stem Cells; Protein Kinase Inhibitors; Pyrazines; Quinazolines; Temozolomide | 2011 |
Rad51 inhibition is an effective means of targeting DNA repair in glioma models and CD133+ tumor-derived cells.
Topics: AC133 Antigen; Antigens, CD; Antineoplastic Agents, Alkylating; Apoptosis; Blotting, Western; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Combined Modality Therapy; Dacarbazine; DNA Repair; Flow Cytometry; Fluorescent Antibody Technique; Glioma; Glycoproteins; Humans; Immunoenzyme Techniques; Peptides; Rad51 Recombinase; Radiation Tolerance; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Small Interfering; Temozolomide; X-Rays | 2011 |
O-methylguanine-DNA methyltransferase (MGMT) mRNA expression predicts outcome in malignant glioma independent of MGMT promoter methylation.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemotherapy, Adjuvant; Dacarbazine; DNA Methylation; Drug Resistance, Neoplasm; Female; Gene Expression Regulation, Neoplastic; Glioma; Humans; Male; Middle Aged; O(6)-Methylguanine-DNA Methyltransferase; Prognosis; Promoter Regions, Genetic; Radiotherapy, Adjuvant; RNA, Messenger; Temozolomide; Treatment Outcome | 2011 |
N-methylpurine DNA glycosylase and DNA polymerase beta modulate BER inhibitor potentiation of glioma cells to temozolomide.
Topics: Antineoplastic Agents, Alkylating; Apoptosis; Blotting, Western; Brain; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Dacarbazine; DNA Glycosylases; DNA Modification Methylases; DNA Polymerase beta; DNA Repair; DNA Repair Enzymes; Drug Synergism; Glioma; Guanine; Humans; Hydroxylamines; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Temozolomide; Tumor Suppressor Proteins | 2011 |
Comparison of corticotropin-releasing factor, dexamethasone, and temozolomide: treatment efficacy and toxicity in U87 and C6 intracranial gliomas.
Topics: Animals; Antineoplastic Agents; Apoptosis; Brain Neoplasms; Cell Line, Tumor; Corticotropin-Releasing Hormone; Dacarbazine; Dexamethasone; Glioma; Humans; Male; Mice; Mice, Nude; Rats; Temozolomide; Treatment Outcome; Xenograft Model Antitumor Assays | 2011 |
Pseudoprogression in patients with glioblastoma multiforme after concurrent radiotherapy and temozolomide.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemotherapy, Adjuvant; Combined Modality Therapy; Dacarbazine; Female; Follow-Up Studies; Glioblastoma; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Neoplasm Staging; Prognosis; Radiotherapy, Adjuvant; Retrospective Studies; Survival Rate; Temozolomide; Young Adult | 2012 |
Temozolomide-induced modification of the CXC chemokine network in experimental gliomas.
Topics: Animals; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Line, Tumor; Chemokines, CXC; Dacarbazine; Drug Resistance, Neoplasm; Female; Glioma; Humans; Mice; Receptors, CXCR; Temozolomide | 2011 |
Temozolomide induced c-Myc-mediated apoptosis via Akt signalling in MGMT expressing glioblastoma cells.
Topics: Antineoplastic Agents, Alkylating; Apoptosis; Brain Neoplasms; Cell Cycle; Cell Line, Tumor; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; Flow Cytometry; Glioblastoma; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-myc; Radiation, Ionizing; RNA, Small Interfering; Temozolomide; Tumor Suppressor Proteins | 2011 |
Can the therapeutic effects of temozolomide be potentiated by stimulating AMP-activated protein kinase with olanzepine and metformin?
Topics: AMP-Activated Protein Kinases; Animals; Antineoplastic Agents, Alkylating; Apoptosis; Benzodiazepines; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; Energy Metabolism; Enzyme Activation; Glioblastoma; Humans; Metformin; Olanzapine; Temozolomide | 2011 |
[Comparison of MGMT and ERCC₂ expression in temozolomide for the treatment of malignant glioma drug resistance and their genetic relationship].
Topics: Adult; Aged; Brain Neoplasms; Dacarbazine; Drug Resistance, Neoplasm; Female; Gene Expression; Genes, Regulator; Glioma; Humans; Male; Middle Aged; O(6)-Methylguanine-DNA Methyltransferase; Temozolomide; Xeroderma Pigmentosum Group D Protein; Young Adult | 2011 |
Promoter methylation and expression of MGMT and the DNA mismatch repair genes MLH1, MSH2, MSH6 and PMS2 in paired primary and recurrent glioblastomas.
Topics: Adaptor Proteins, Signal Transducing; Adenosine Triphosphatases; Adult; Aged; Antineoplastic Agents; Brain Neoplasms; Dacarbazine; Disease-Free Survival; DNA Mismatch Repair; DNA Repair Enzymes; DNA-Binding Proteins; Female; Glioblastoma; Humans; Male; Middle Aged; Mismatch Repair Endonuclease PMS2; MutL Protein Homolog 1; MutS Homolog 2 Protein; Neoplasm Recurrence, Local; Nuclear Proteins; O(6)-Methylguanine-DNA Methyltransferase; Promoter Regions, Genetic; Temozolomide | 2011 |
Radiation-induced astrocytoma with rapid malignant transformation: case report.
Topics: Antineoplastic Agents, Alkylating; Astrocytoma; Basal Ganglia; Brain Neoplasms; Cell Transformation, Neoplastic; Cerebellar Neoplasms; Dacarbazine; Fatal Outcome; Gait Disorders, Neurologic; Humans; Hydrocephalus; Male; Neoplasms, Germ Cell and Embryonal; Neoplasms, Radiation-Induced; Neoplasms, Second Primary; Temozolomide; Time Factors; Young Adult | 2011 |
MGMT promoter methylation and temozolomide response in choroid plexus carcinoma.
Topics: Adult; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemoradiotherapy, Adjuvant; Choroid Plexus; Choroid Plexus Neoplasms; Dacarbazine; DNA Methylation; Humans; Hydrocephalus; Lateral Ventricles; Magnetic Resonance Imaging; Male; O(6)-Methylguanine-DNA Methyltransferase; Promoter Regions, Genetic; Temozolomide; Treatment Outcome | 2011 |
Enhanced brain targeting of temozolomide in polysorbate-80 coated polybutylcyanoacrylate nanoparticles.
Topics: Animals; Blood-Brain Barrier; Brain; Brain Neoplasms; Dacarbazine; Microscopy, Electron, Transmission; Nanoparticles; Organ Specificity; Polysorbates; Rats; Rats, Wistar; Spectroscopy, Fourier Transform Infrared; Temozolomide | 2011 |
[Benefit of a prolonged adjuvant treatment with temozolomide for the management of patients with glioblastoma].
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemotherapy, Adjuvant; Combined Modality Therapy; Dacarbazine; Drug Administration Schedule; Female; Glioblastoma; Hematologic Diseases; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Palliative Care; Radiotherapy, Conformal; Retrospective Studies; Temozolomide; Treatment Outcome | 2011 |
Growth-inhibitory and chemosensitizing effects of the glutathione-S-transferase-π-activated nitric oxide donor PABA/NO in malignant gliomas.
Topics: 4-Aminobenzoic Acid; Animals; Antineoplastic Combined Chemotherapy Protocols; Azo Compounds; Brain Neoplasms; Carboplatin; Cell Line, Tumor; Cell Survival; Dacarbazine; Drug Evaluation, Preclinical; Enzyme Activation; Glioma; Glutathione S-Transferase pi; Growth Inhibitors; Humans; Nitric Oxide Donors; para-Aminobenzoates; Rats; Rats, Nude; Temozolomide | 2012 |
A GATA4-regulated tumor suppressor network represses formation of malignant human astrocytomas.
Topics: Animals; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Cyclin D1; Cyclin-Dependent Kinase Inhibitor p21; Dacarbazine; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; GATA4 Transcription Factor; Glioblastoma; Humans; Mice; Promoter Regions, Genetic; Temozolomide; Tumor Suppressor Proteins | 2011 |
Benefits of interferon-β and temozolomide combination therapy for newly diagnosed primary glioblastoma with the unmethylated MGMT promoter: A multicenter study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Child; Combined Modality Therapy; Dacarbazine; DNA Methylation; Female; Glioblastoma; Humans; Interferon-beta; Male; Middle Aged; O(6)-Methylguanine-DNA Methyltransferase; Prognosis; Promoter Regions, Genetic; Temozolomide | 2011 |
Cytoreductive surgery of glioblastoma as the key to successful adjuvant therapies: new arguments in an old discussion.
Topics: Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Carmustine; Chemotherapy, Adjuvant; Combined Modality Therapy; Cranial Irradiation; Dacarbazine; Dose Fractionation, Radiation; Female; Follow-Up Studies; Glioblastoma; Humans; Male; Middle Aged; Prognosis; Proportional Hazards Models; Radiotherapy, Adjuvant; Randomized Controlled Trials as Topic; Survival Rate; Temozolomide | 2011 |
Safety and efficacy of stereotactic radiosurgery and adjuvant bevacizumab in patients with recurrent malignant gliomas.
Topics: Adult; Aged; Angiogenesis Inhibitors; Antibodies, Monoclonal, Humanized; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Disease Progression; Female; Follow-Up Studies; Glioma; Humans; Male; Middle Aged; Multivariate Analysis; Neoplasm Recurrence, Local; Radiosurgery; Retrospective Studies; Salvage Therapy; Temozolomide; Treatment Failure; Vascular Endothelial Growth Factor A; Young Adult | 2012 |
Prognostic impact of postoperative, pre-irradiation (18)F-fluoroethyl-l-tyrosine uptake in glioblastoma patients treated with radiochemotherapy.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Combined Modality Therapy; Contrast Media; Cranial Irradiation; Dacarbazine; Dose Fractionation, Radiation; Female; Fluorine Radioisotopes; Gadolinium DTPA; Glioblastoma; Humans; Image Interpretation, Computer-Assisted; Magnetic Resonance Imaging; Male; Middle Aged; Neoplasm, Residual; Positron-Emission Tomography; Prognosis; Proportional Hazards Models; Prospective Studies; Survival Rate; Temozolomide; Treatment Outcome; Tumor Burden; Tyrosine | 2011 |
Response to temozolomide in supratentorial multifocal recurrence of malignant ependymoma.
Topics: Adult; Antineoplastic Agents; Brain Neoplasms; Dacarbazine; Disease Progression; Ependymoma; Female; Follow-Up Studies; Humans; Magnetic Resonance Imaging; Recurrence; Supratentorial Neoplasms; Temozolomide; Treatment Outcome | 2011 |
Pathological changes after autologous formalin-fixed tumor vaccine therapy combined with temozolomide for glioblastoma - three case reports - .
Topics: Adjuvants, Immunologic; Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cancer Vaccines; Combined Modality Therapy; Dacarbazine; Female; Formaldehyde; Frontal Lobe; Glioblastoma; Humans; Male; Middle Aged; Temozolomide; Treatment Outcome | 2011 |
Cediranib enhances control of wild type EGFR and EGFRvIII-expressing gliomas through potentiating temozolomide, but not through radiosensitization: implications for the clinic.
Topics: Animals; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cell Survival; Dacarbazine; ErbB Receptors; Glioma; Humans; Immunoblotting; Mice; Mice, Nude; Quinazolines; Radiation Tolerance; Temozolomide; Tumor Cells, Cultured; Tumor Stem Cell Assay; Vascular Endothelial Growth Factor A; X-Rays | 2011 |
Seizure control: a secondary benefit of chemotherapeutic temozolomide in brain cancer patients.
Topics: Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Dacarbazine; Electroencephalography; Female; Humans; Seizures; Temozolomide | 2011 |
How fine a slice: treatment of newly diagnosed glioblastoma with an epidermal growth factor receptor variant III peptide vaccine.
Topics: Brain Neoplasms; Cancer Vaccines; Combined Modality Therapy; Dacarbazine; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; ErbB Receptors; Glioblastoma; Humans; Temozolomide; Tumor Escape; Tumor Suppressor Proteins | 2011 |
Overall survival and extent of surgery in adult versus elderly glioblastoma patients: A population based retrospective study.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Biopsy; Brain; Brain Neoplasms; Chemoradiotherapy, Adjuvant; Combined Modality Therapy; Dacarbazine; Female; Glioblastoma; Humans; Male; Middle Aged; Quality of Life; Retrospective Studies; Survival Rate; Temozolomide | 2011 |
Detection of early response to temozolomide treatment in brain tumors using hyperpolarized 13C MR metabolic imaging.
Topics: Animals; Antineoplastic Agents, Alkylating; Brain Neoplasms; Carbon Isotopes; Cell Line, Tumor; Dacarbazine; Drug Monitoring; Glioblastoma; Humans; Lactic Acid; Magnetic Resonance Imaging; Male; Neoplasm Transplantation; Pyruvic Acid; Rats; Temozolomide; Treatment Outcome | 2011 |
Primary gliosarcoma--clinical experience from a regional cancer centre in north India.
Topics: Adult; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cancer Care Facilities; Combined Modality Therapy; Dacarbazine; Developing Countries; Female; Follow-Up Studies; Gliosarcoma; Humans; India; Intracranial Hypertension; Kaplan-Meier Estimate; Karnofsky Performance Status; Lost to Follow-Up; Magnetic Resonance Imaging; Male; Middle Aged; Neoplasm Recurrence, Local; Psychomotor Disorders; Salvage Therapy; Survival Rate; Temozolomide; Treatment Outcome; Young Adult | 2011 |
Predicting the outcome of grade II glioma treated with temozolomide using proton magnetic resonance spectroscopy.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Aspartic Acid; Brain Neoplasms; Choline; Creatine; Dacarbazine; Female; Glioma; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Prospective Studies; Protons; Temozolomide; Treatment Outcome | 2011 |
The effect of PTEN on proliferation and drug-, and radiosensitivity in malignant glioma cells.
Topics: Adenoviridae; Antineoplastic Agents, Alkylating; Apoptosis; Blotting, Western; Brain Neoplasms; Cell Cycle; Cell Proliferation; Combined Modality Therapy; Dacarbazine; Genetic Therapy; Glioma; Humans; PTEN Phosphohydrolase; Radiation Tolerance; Radiation, Ionizing; Temozolomide; Tumor Cells, Cultured | 2011 |
Leptomeningeal dissemination of anaplastic glioma: prolonged survival in two patients treated with temozolomide.
Topics: Aged; Antineoplastic Agents; Brain Neoplasms; Dacarbazine; Glioma; Humans; Male; Meningeal Carcinomatosis; Temozolomide | 2011 |
International retrospective study of over 1000 adults with anaplastic oligodendroglial tumors.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Chromosomes, Human, Pair 1; Cohort Studies; Combined Modality Therapy; Dacarbazine; Disease Progression; Female; Follow-Up Studies; Humans; International Agencies; Lomustine; Male; Middle Aged; Oligodendroglioma; Procarbazine; Radiotherapy; Retrospective Studies; Survival Rate; Temozolomide; Treatment Outcome; Vincristine; Young Adult | 2011 |
Rare phenomenon: liver metastases from glioblastoma multiforme.
Topics: Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Bevacizumab; Biomarkers, Tumor; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Glioblastoma; Humans; Immunohistochemistry; Liver Neoplasms; Male; Radiotherapy; Temozolomide | 2011 |
Glioblastoma: patterns of recurrence and efficacy of salvage treatments.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Disease Progression; Female; Glioblastoma; Humans; Kaplan-Meier Estimate; Magnetic Resonance Imaging; Male; Middle Aged; Neoplasm Recurrence, Local; Proportional Hazards Models; Radiotherapy; Retrospective Studies; Salvage Therapy; Temozolomide; Tomography, X-Ray Computed | 2011 |
Immunotherapy for glioblastoma: the devil is in the details.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Cancer Vaccines; Chemotherapy, Adjuvant; Clinical Trials, Phase II as Topic; Dacarbazine; ErbB Receptors; Glioblastoma; Humans; Mutation; Radiotherapy, Adjuvant; Survival Analysis; Temozolomide | 2011 |
YB-1 dependent virotherapy in combination with temozolomide as a multimodal therapy approach to eradicate malignant glioma.
Topics: Adenoviridae; Animals; Antineoplastic Combined Chemotherapy Protocols; Blotting, Southern; Blotting, Western; Brain Neoplasms; Cisplatin; Combined Modality Therapy; Dacarbazine; Daunorubicin; Genetic Therapy; Genetic Vectors; Glioma; Humans; Immunoenzyme Techniques; Mice; Mice, Nude; Oncolytic Virotherapy; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Temozolomide; Tumor Cells, Cultured; Virus Replication; Y-Box-Binding Protein 1 | 2011 |
A small-molecule IAP inhibitor overcomes resistance to cytotoxic therapies in malignant gliomas in vitro and in vivo.
Topics: Animals; Antineoplastic Agents; Apoptosis; Blotting, Western; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Combined Modality Therapy; Dacarbazine; Gamma Rays; Glioma; Humans; In Vitro Techniques; Inhibitor of Apoptosis Proteins; Mice; Mice, Nude; Oligopeptides; Radiation-Sensitizing Agents; Temozolomide; Xenograft Model Antitumor Assays | 2011 |
Prolonged temozolomide for treatment of glioblastoma: preliminary clinical results and prognostic value of p53 overexpression.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Proliferation; Chemotherapy, Adjuvant; Combined Modality Therapy; Dacarbazine; Disease Progression; Disease-Free Survival; Dose-Response Relationship, Drug; ErbB Receptors; Female; Gene Expression Regulation, Neoplastic; Genes, p53; Glioblastoma; Humans; Immunohistochemistry; In Situ Hybridization, Fluorescence; Male; Middle Aged; Prognosis; Retrospective Studies; Temozolomide | 2012 |
Intravenous administration of temozolomide as a useful alternative over oral treatment with temozolomide capsules in patients with gliomas.
Topics: Adult; Antineoplastic Agents, Alkylating; Brain Neoplasms; Capsules; Child; Child, Preschool; Dacarbazine; Female; Glioma; Humans; Injections, Intravenous; Male; Temozolomide; Young Adult | 2012 |
Determination of temozolomide in serum and brain tumor with micellar electrokinetic capillary chromatography.
Topics: Antineoplastic Agents; Brain Chemistry; Brain Neoplasms; Chromatography, Micellar Electrokinetic Capillary; Dacarbazine; Humans; Temozolomide | 2011 |
[Cutaneous neutrophils infiltrates. Case 4. Pseudo-tumoral cutaneous alternariosis].
Topics: Aged, 80 and over; Alternaria; Antifungal Agents; Antineoplastic Agents, Alkylating; Brain Neoplasms; Carcinoma, Verrucous; Combined Modality Therapy; Dacarbazine; Dermatomycoses; Diagnosis, Differential; Ependymoma; Fatal Outcome; Folliculitis; Frontal Lobe; Hand Dermatoses; Humans; Immunocompromised Host; Keratosis; Male; Neutrophils; Pyrimidines; Skin Neoplasms; Staining and Labeling; Temozolomide; Triazoles; Voriconazole | 2011 |
Immunosuppression in patients with high-grade gliomas treated with radiation and temozolomide.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; CD4 Lymphocyte Count; Chemoradiotherapy; Dacarbazine; Female; Follow-Up Studies; Glioma; Hospitalization; Humans; Immunosuppression Therapy; Kaplan-Meier Estimate; Karnofsky Performance Status; Male; Middle Aged; Multivariate Analysis; Neoplasm Grading; Outcome Assessment, Health Care; Prospective Studies; Temozolomide; Time Factors | 2011 |
[Problems of chemotherapy for glioma].
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; DNA; DNA Mismatch Repair; Drug Resistance, Neoplasm; Glioma; Humans; Temozolomide | 2011 |
Combination of neoadjuvant chemotherapy followed by surgical resection as a new strategy for WHO grade II gliomas: a study of cognitive status and quality of life.
Topics: Adult; Antineoplastic Agents; Brain Neoplasms; Chemotherapy, Adjuvant; Cognition; Dacarbazine; Female; Glioma; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Neoadjuvant Therapy; Neoplasm Grading; Neuropsychological Tests; Neurosurgical Procedures; Quality of Life; Retrospective Studies; Temozolomide; Treatment Outcome; Young Adult | 2012 |
MGMT promoter gene methylation in pediatric glioblastoma: analysis using MS-MLPA.
Topics: Adolescent; Antineoplastic Agents; Brain Neoplasms; Child; Child, Preschool; Dacarbazine; Disease-Free Survival; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Female; Glioblastoma; Humans; Infant; Kaplan-Meier Estimate; Male; Nucleic Acid Amplification Techniques; Polymerase Chain Reaction; Promoter Regions, Genetic; Reproducibility of Results; Temozolomide; Tumor Suppressor Proteins | 2011 |
Ifosfamide, carboplatin and etoposide in recurrent malignant glioma.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Carboplatin; Dacarbazine; Drug Administration Schedule; Etoposide; Female; Glioma; Humans; Ifosfamide; Male; Middle Aged; Recurrence; Retrospective Studies; Temozolomide; Treatment Failure | 2011 |
Gene expression profiles predicting the response to IFN-β and a combination of temozolomide and IFN-β in malignant gliomas.
Topics: 2',5'-Oligoadenylate Synthetase; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; Down-Regulation; Enzyme Induction; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Glioma; Humans; Interferon-beta; Male; Oligonucleotide Array Sequence Analysis; Temozolomide | 2011 |
Hepatitis B virus reactivation associated with temozolomide for malignant glioma: a case report and recommendation for prophylaxis.
Topics: Antineoplastic Agents, Alkylating; Antiviral Agents; Astrocytoma; Brain Neoplasms; Carrier State; Chemoradiotherapy; Dacarbazine; Female; Hepatitis B; Hepatitis B virus; Humans; Immunosuppression Therapy; Middle Aged; Temozolomide; Virus Activation | 2012 |
[Significant regression of glioblastoma with low level of Mgmt gene expression following radiotherapy].
Topics: Adult; Antineoplastic Agents, Alkylating; Biomarkers, Tumor; Brain Neoplasms; Chemotherapy, Adjuvant; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; DNA, Neoplasm; Dose Fractionation, Radiation; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Magnetic Resonance Imaging; Male; Proton Therapy; Radiotherapy, Adjuvant; Radiotherapy, Conformal; Temozolomide; Treatment Outcome; Tumor Suppressor Proteins | 2011 |
In regard McDonald et al., to Pattern of failure after limited margin radiotherapy and temozolomide for glioblastoma (Int J Radiat Oncol Biol Phys 2011;79:130-136).
Topics: Antineoplastic Agents; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Disease Progression; Glioblastoma; Humans; Neoplasm Recurrence, Local; Neoplasm Staging; Radiotherapy Planning, Computer-Assisted; Temozolomide; Treatment Failure; Tumor Burden | 2011 |
Method for novel anti-cancer drug development using tumor explants of surgical specimens.
Topics: Antineoplastic Agents; Brain Neoplasms; Dacarbazine; Drug Screening Assays, Antitumor; Flow Cytometry; Glioblastoma; Humans; Injections, Intralesional; Temozolomide | 2011 |
Prolonged survival when temozolomide is added to accelerated radiotherapy for glioblastoma multiforme.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemotherapy, Adjuvant; Combined Modality Therapy; Dacarbazine; Dose Fractionation, Radiation; Female; Follow-Up Studies; Glioblastoma; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Survival Rate; Temozolomide; Young Adult | 2011 |
Temozolomide in relapsed pediatric brain tumors: 14 cases from a single center.
Topics: Adolescent; Antineoplastic Agents, Alkylating; Brain Neoplasms; Child; Child, Preschool; Dacarbazine; Female; Humans; Infant; Male; Neoplasm Recurrence, Local; Retrospective Studies; Temozolomide; Young Adult | 2012 |
Early-stage progress on glioma vaccines.
Topics: Antibodies, Monoclonal; Antineoplastic Agents; Brain Neoplasms; Cancer Vaccines; Clinical Trials as Topic; Dacarbazine; Dendritic Cells; Drug Resistance, Neoplasm; Glioblastoma; Glioma; Humans; Ipilimumab; Temozolomide; Treatment Outcome; Vaccines, Subunit | 2011 |
Adult glioblastoma multiforme survival in the temozolomide era: a population-based analysis of Surveillance, Epidemiology, and End Results registries.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Female; Glioblastoma; Humans; Male; Middle Aged; Prognosis; SEER Program; Temozolomide; Treatment Outcome; United States | 2012 |
Inhibition of STAT3 reverses alkylator resistance through modulation of the AKT and β-catenin signaling pathways.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents, Alkylating; beta Catenin; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; Disease-Free Survival; Drug Synergism; Female; Glioblastoma; Humans; Immunohistochemistry; Male; Middle Aged; Phosphorylation; Proto-Oncogene Proteins c-akt; Pyridines; Retrospective Studies; Signal Transduction; STAT3 Transcription Factor; Temozolomide; Tyrphostins; Young Adult | 2011 |
Bevacizumab-induced reversible posterior leukoencephalopathy syndrome and successful retreatment in a patient with glioblastoma.
Topics: Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Brain Neoplasms; Dacarbazine; Female; Glioblastoma; Humans; Middle Aged; Posterior Leukoencephalopathy Syndrome; Temozolomide | 2011 |
Communicating hydrocephalus following surgery and adjuvant radiochemotherapy for glioblastoma.
Topics: Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cerebrospinal Fluid Shunts; Chemoradiotherapy, Adjuvant; Craniology; Dacarbazine; Female; Glioblastoma; Humans; Hydrocephalus; Logistic Models; Male; Middle Aged; Multivariate Analysis; Neoplasm Recurrence, Local; Postoperative Complications; Prognosis; Retrospective Studies; Temozolomide | 2011 |
Prognostic significance of IDH-1 and MGMT in patients with glioblastoma: one step forward, and one step back?
Topics: Adult; Aged; Brain Neoplasms; Dacarbazine; DNA Methylation; Glioblastoma; Humans; Isocitrate Dehydrogenase; Medical Oncology; Middle Aged; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Prognosis; Promoter Regions, Genetic; Temozolomide; Treatment Outcome | 2011 |
Improvement in the standard treatment for experimental glioma by fusing antibody Fc domain to endostatin.
Topics: Administration, Oral; Angiogenesis Inhibitors; Animals; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Dacarbazine; Disease Models, Animal; Drug Delivery Systems; Endostatins; Gliosarcoma; Immunoglobulin Fc Fragments; Male; Rats; Rats, Inbred F344; Survival Analysis; Temozolomide | 2011 |
Noscapine inhibits tumor growth in TMZ-resistant gliomas.
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Cell Division; Dacarbazine; Drug Resistance, Neoplasm; Female; Glioblastoma; Humans; Mice; Mice, Nude; Noscapine; Temozolomide; Xenograft Model Antitumor Assays | 2011 |
Conditional probability of survival in patients with newly diagnosed glioblastoma.
Topics: Adult; Age Factors; Aged; Antineoplastic Agents; Brain Neoplasms; Chemotherapy, Adjuvant; Clinical Trials as Topic; Dacarbazine; Disease Progression; Female; Glioblastoma; Humans; Kaplan-Meier Estimate; Karnofsky Performance Status; Male; Middle Aged; Predictive Value of Tests; Prognosis; Proportional Hazards Models; Radiotherapy, Adjuvant; Risk Factors; Temozolomide | 2011 |
Protein alterations associated with temozolomide resistance in subclones of human glioblastoma cell lines.
Topics: Antineoplastic Agents, Alkylating; Apoptosis; Biomarkers, Tumor; Blotting, Western; Brain Neoplasms; Cell Adhesion; Cell Cycle; Cell Movement; Cell Proliferation; Dacarbazine; Drug Resistance, Neoplasm; Electrophoresis, Gel, Two-Dimensional; Flow Cytometry; Glioblastoma; Humans; In Situ Nick-End Labeling; Real-Time Polymerase Chain Reaction; RNA, Messenger; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Temozolomide; Wound Healing | 2012 |
Rechallenge with temozolomide in recurrent glioma.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Drug Administration Schedule; Glioma; Humans; Neoplasm Recurrence, Local; Retreatment; Temozolomide | 2011 |
Low-dose fractionated radiotherapy and concomitant chemotherapy in glioblastoma multiforme with poor prognosis: a feasibility study.
Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cisplatin; Combined Modality Therapy; Dacarbazine; Dose Fractionation, Radiation; Feasibility Studies; Female; Glioblastoma; Humans; Male; Middle Aged; Nitrosourea Compounds; Organophosphorus Compounds; Palliative Care; Prognosis; Temozolomide | 2012 |
Primary central nervous system lymphoma presenting as Parinaud syndrome.
Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cranial Irradiation; Dacarbazine; Diagnosis, Differential; Diplopia; Female; Humans; Lymphoma, Large B-Cell, Diffuse; Magnetic Resonance Imaging; Methotrexate; Middle Aged; Ocular Motility Disorders; Spinal Puncture; Temozolomide; Tomography, X-Ray Computed | 2011 |
Toxicity after radiochemotherapy for glioblastoma using temozolomide--a retrospective evaluation.
Topics: Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemoradiotherapy; Dacarbazine; Disease Progression; Female; Glioblastoma; Humans; Male; Middle Aged; Retrospective Studies; Risk; Temozolomide; Time Factors; Treatment Outcome | 2011 |
Reactivation of hepatitis B virus after glioblastoma treatment with temozolomide--case report.
Topics: Acute Disease; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Fatal Outcome; Glioblastoma; Hepatitis B; Hepatitis B virus; Humans; Male; Middle Aged; Temozolomide; Virus Activation | 2011 |
IDH mutations predict longer survival and response to temozolomide in secondary glioblastoma.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Base Sequence; Biomarkers, Tumor; Brain Neoplasms; Dacarbazine; Disease-Free Survival; DNA Methylation; DNA Modification Methylases; Female; Glioblastoma; Humans; Isocitrate Dehydrogenase; Male; Middle Aged; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Promoter Regions, Genetic; Sequence Analysis, DNA; Temozolomide; Tumor Suppressor Protein p53 | 2012 |
Avastin: more questions than answers. . .
Topics: Angiogenesis Inhibitors; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Brain Neoplasms; Camptothecin; Chemoradiotherapy; Dacarbazine; Etoposide; Female; Glioblastoma; Glioma; Humans; Male; Neoplasm Recurrence, Local; Salvage Therapy; Supratentorial Neoplasms; Temozolomide | 2012 |
Radiochemotherapy with temozolomide for patients with glioblastoma. Prognostic factors and long-term outcome of unselected patients from a single institution.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Biopsy; Brain Neoplasms; Chemoradiotherapy, Adjuvant; Combined Modality Therapy; Dacarbazine; Disease-Free Survival; Dose Fractionation, Radiation; Feasibility Studies; Female; Glioblastoma; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Neoplasm Staging; Prognosis; Radiotherapy Planning, Computer-Assisted; Retrospective Studies; Temozolomide; Young Adult | 2011 |
Valproic acid sensitizes human glioma cells for temozolomide and γ-radiation.
Topics: Anticonvulsants; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Proliferation; Dacarbazine; Gamma Rays; Glioma; Humans; Radiation Tolerance; Radiation-Sensitizing Agents; Temozolomide; Tumor Cells, Cultured; Tumor Stem Cell Assay; Valproic Acid | 2012 |
Reirradiation and concomitant metronomic temozolomide: an efficient combination for local control in medulloblastoma disease?
Topics: Administration, Metronomic; Adolescent; Adult; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemoradiotherapy; Child; Dacarbazine; Fatal Outcome; Female; Humans; Male; Medulloblastoma; Radiation Dosage; Retreatment; Temozolomide; Young Adult | 2011 |
Glioblastoma survival in the United States before and during the temozolomide era.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Female; Glioblastoma; Humans; Kaplan-Meier Estimate; Longitudinal Studies; Male; Middle Aged; Proportional Hazards Models; Retrospective Studies; Temozolomide; Treatment Outcome; United States; Young Adult | 2012 |
Concurrent temozolomide and dose-escalated intensity-modulated radiation therapy in newly diagnosed glioblastoma.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemoradiotherapy; Dacarbazine; Dose Fractionation, Radiation; Female; Follow-Up Studies; Glioblastoma; Humans; Male; Methionine; Middle Aged; Positron-Emission Tomography; Prognosis; Radiopharmaceuticals; Radiotherapy, Intensity-Modulated; Salvage Therapy; Survival Rate; Temozolomide; Tissue Distribution; Young Adult | 2012 |
Downregulation of miR-221/222 sensitizes glioma cells to temozolomide by regulating apoptosis independently of p53 status.
Topics: Apoptosis; Apoptosis Regulatory Proteins; Apoptotic Protease-Activating Factor 1; bcl-2-Associated X Protein; Brain Neoplasms; Caspase 3; Cytochromes c; Dacarbazine; Down-Regulation; Gene Knockdown Techniques; Glioma; Humans; MicroRNAs; Mitochondria; Proto-Oncogene Proteins; RNA, Small Interfering; Signal Transduction; Temozolomide; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2012 |
Resveratrol enhances the therapeutic effect of temozolomide against malignant glioma in vitro and in vivo by inhibiting autophagy.
Topics: Animals; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Autophagy; Brain Neoplasms; Cell Line, Tumor; Cell Survival; Dacarbazine; Drug Synergism; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Female; Glioma; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Phosphorylation; Reactive Oxygen Species; Resveratrol; Stilbenes; Temozolomide; Tumor Burden; Xenograft Model Antitumor Assays | 2012 |
Higher topoisomerase 2 alpha gene transcript levels predict better prognosis in GBM patients receiving temozolomide chemotherapy: identification of temozolomide as a TOP2A inhibitor.
Topics: Antigens, Neoplasm; Antineoplastic Agents; Brain Neoplasms; Camptothecin; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cohort Studies; Dacarbazine; DNA Topoisomerases, Type II; DNA-Binding Proteins; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Gene Expression Regulation, Enzymologic; Glioblastoma; Humans; Male; Poly-ADP-Ribose Binding Proteins; Prognosis; RNA, Messenger; Temozolomide; Topoisomerase II Inhibitors | 2012 |
Patterns of imaging failures in glioblastoma patients treated with chemoradiation: a retrospective study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Brain Neoplasms; Chemoradiotherapy; Dacarbazine; Diagnostic Imaging; Female; Glioblastoma; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Neurosurgical Procedures; Retrospective Studies; Temozolomide; Treatment Outcome; Young Adult | 2012 |
Prolonged administration of temozolomide in adult patients with anaplastic glioma.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Carcinoma; Dacarbazine; Disease Progression; Feasibility Studies; Female; Follow-Up Studies; Glioma; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Prognosis; Retrospective Studies; Survival Rate; Temozolomide; Time Factors | 2011 |
Prognostic impact of hemoglobin level and other factors in patients with high-grade gliomas treated with postoperative radiochemotherapy and sequential chemotherapy based on temozolomide: a 10-year experience at a single institution.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Chemoradiotherapy, Adjuvant; Combined Modality Therapy; Cranial Irradiation; Dacarbazine; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Female; Glioblastoma; Hemoglobinometry; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Prognosis; Temozolomide; Tumor Suppressor Proteins | 2011 |
Temozolomide induced liver injury.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemical and Drug Induced Liver Injury; Chemoradiotherapy; Dacarbazine; Female; Glioblastoma; Humans; Middle Aged; Temozolomide | 2011 |
Early post-treatment pseudo-progression amongst glioblastoma multiforme patients treated with radiotherapy and temozolomide: a retrospective analysis.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemoradiotherapy; Dacarbazine; Female; Glioblastoma; Humans; Male; Middle Aged; Temozolomide; Treatment Outcome; Young Adult | 2011 |
Inhibition of Aurora kinases enhances chemosensitivity to temozolomide and causes radiosensitization in glioblastoma cells.
Topics: Antineoplastic Agents, Alkylating; Apoptosis; Aurora Kinase B; Aurora Kinases; Benzamides; Blotting, Western; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Dacarbazine; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Quinazolines; Radiation-Sensitizing Agents; Reverse Transcriptase Polymerase Chain Reaction; RNA, Neoplasm; Temozolomide; Time Factors | 2012 |
[Efficacy and safety of 3-dimensional conformal radiotherapy combined with temozolomide for glioma].
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Female; Glioma; Humans; Male; Middle Aged; Postoperative Period; Radiotherapy, Conformal; Retrospective Studies; Survival Analysis; Temozolomide | 2011 |
Oncolytic virus-mediated manipulation of DNA damage responses: synergy with chemotherapy in killing glioblastoma stem cells.
Topics: Animals; Antineoplastic Agents, Alkylating; Ataxia Telangiectasia Mutated Proteins; Brain Neoplasms; Cell Cycle Proteins; Cell Line, Tumor; Cell Survival; Chlorocebus aethiops; Dacarbazine; DNA Damage; DNA Modification Methylases; DNA Repair; DNA Repair Enzymes; DNA-Binding Proteins; Female; Gene Knockdown Techniques; Genetic Vectors; Glioblastoma; Humans; Immunoblotting; Immunohistochemistry; Methylation; Mice; Mice, Nude; Neoplastic Stem Cells; Oncolytic Virotherapy; Polymerase Chain Reaction; Protein Serine-Threonine Kinases; Simplexvirus; Temozolomide; Tumor Suppressor Proteins; Vero Cells; Virus Replication | 2012 |
Neuronal markers are expressed in human gliomas and NSE knockdown sensitizes glioblastoma cells to radiotherapy and temozolomide.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Biomarkers, Tumor; Biopsy; Blotting, Western; Brain Neoplasms; Cell Hypoxia; Cell Line, Tumor; Cell Movement; Dacarbazine; Electric Impedance; Female; Gene Knockout Techniques; Glioblastoma; Glioma; Humans; Immunohistochemistry; Male; Microtubule-Associated Proteins; Middle Aged; Neurofilament Proteins; Phosphopyruvate Hydratase; Real-Time Polymerase Chain Reaction; Temozolomide; Tubulin; Young Adult | 2011 |
Retrospective study of patients with brain metastases from melanoma receiving concurrent whole-brain radiation and temozolomide.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Disease-Free Survival; Female; Humans; Male; Melanoma; Middle Aged; Neoplasm Metastasis; Radiotherapy; Retrospective Studies; Temozolomide; Time Factors | 2011 |
Complete remission after bevacizumab plus temozolomide in a patient with recurrent glioblastoma multiforme.
Topics: Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Brain Neoplasms; Dacarbazine; Female; Glioblastoma; Humans; Magnetic Resonance Imaging; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Staging; Prognosis; Remission Induction; Temozolomide | 2012 |
Volumetric and MGMT parameters in glioblastoma patients: survival analysis.
Topics: Adult; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemoradiotherapy; Dacarbazine; Disease-Free Survival; DNA Modification Methylases; DNA Repair Enzymes; Female; Gene Expression Profiling; Glioblastoma; Humans; Magnetic Resonance Imaging; Male; Methylation; Middle Aged; Multivariate Analysis; Predictive Value of Tests; Prognosis; Prospective Studies; Survival Analysis; Temozolomide; Tumor Burden; Tumor Suppressor Proteins | 2012 |
Radiotherapy with and without temozolomide in elderly patients with glioblastoma.
Topics: Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemoradiotherapy; Dacarbazine; Female; Germany; Glioblastoma; Humans; Male; Prevalence; Prognosis; Radiotherapy, Conformal; Risk Assessment; Risk Factors; Survival Analysis; Survival Rate; Temozolomide; Treatment Outcome | 2012 |
[Brain metastasis in breast cancer].
Topics: Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Breast Neoplasms; Chemoradiotherapy; Dacarbazine; Dexamethasone; Dose Fractionation, Radiation; Drug Administration Schedule; Female; Humans; Karnofsky Performance Status; Lomustine; Middle Aged; Retrospective Studies; Survival Analysis; Temozolomide; Treatment Outcome; Vincristine | 2011 |
Patterns of care and survival for patients with glioblastoma multiforme diagnosed during 2006.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemotherapy, Adjuvant; Dacarbazine; Female; Glioblastoma; Humans; Male; Middle Aged; Patient Care; Temozolomide; United States; Young Adult | 2012 |
Temozolomide for pediatric high-grade gliomas.
Topics: Adolescent; Antineoplastic Agents, Alkylating; Brain Neoplasms; Child; Child, Preschool; Dacarbazine; Female; Glioma; Humans; Longitudinal Studies; Male; Retrospective Studies; Survival Analysis; Temozolomide; Young Adult | 2012 |
Presence of an oligodendroglioma-like component in newly diagnosed glioblastoma identifies a pathogenetically heterogeneous subgroup and lacks prognostic value: central pathology review of the EORTC_26981/NCIC_CE.3 trial.
Topics: Adolescent; Adult; Aged; Brain Neoplasms; Chemoradiotherapy; Clinical Trials, Phase III as Topic; Dacarbazine; DNA Methylation; ErbB Receptors; Female; Glioblastoma; Humans; Male; Middle Aged; Mutation; Oligodendroglioma; Prognosis; Survival Analysis; Temozolomide; Treatment Outcome; Young Adult | 2012 |
[Retrospective analysis of 24 recurrent glioblastoma after chemoradiation and treated with nitrosoureas or irinotecan and bevacizumab].
Topics: Adult; Aged; Angiogenesis Inhibitors; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Brain Neoplasms; Camptothecin; Carmustine; Chemoradiotherapy; Chemotherapy, Adjuvant; Cohort Studies; Dacarbazine; Drug Therapy, Combination; Glioblastoma; Humans; Irinotecan; Lomustine; Middle Aged; Neoplasm Recurrence, Local; Nitrosourea Compounds; Radiation-Sensitizing Agents; Retrospective Studies; Temozolomide | 2012 |
Prospective cohort study of radiotherapy with concomitant and adjuvant temozolomide chemotherapy for glioblastoma patients with no or minimal residual enhancing tumor load after surgery.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cohort Studies; Combined Modality Therapy; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; Female; Glioblastoma; Humans; Kaplan-Meier Estimate; Magnetic Resonance Imaging; Male; Methylation; Middle Aged; Postoperative Complications; Radiotherapy; Retrospective Studies; Temozolomide; Treatment Outcome; Tumor Suppressor Proteins; Young Adult | 2012 |
[Protracted low-dose temozolomide combined with concomitant whole brain radiotherapy for brain metastases from non-small cell lung cancer].
Topics: Adult; Aged; Agranulocytosis; Antineoplastic Agents, Alkylating; Brain Neoplasms; Carcinoma, Non-Small-Cell Lung; Chemoradiotherapy; Dacarbazine; Disease-Free Survival; Dose-Response Relationship, Drug; Female; Humans; Lung Neoplasms; Male; Middle Aged; Remission Induction; Survival Rate; Temozolomide; Vomiting | 2011 |
Different involvement of autophagy in human malignant glioma cell lines undergoing irradiation and temozolomide combined treatments.
Topics: Apoptosis Regulatory Proteins; Autophagy; Autophagy-Related Protein 5; Beclin-1; Brain Neoplasms; Cell Line, Tumor; Cell Survival; Combined Modality Therapy; Dacarbazine; Glioblastoma; Humans; Membrane Proteins; Microtubule-Associated Proteins; Radiation-Sensitizing Agents; RNA Interference; RNA, Small Interfering; Sirolimus; Temozolomide | 2012 |
Induction of brain tumor stem cell apoptosis by FTY720: a potential therapeutic agent for glioblastoma.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Apoptosis Regulatory Proteins; Bcl-2-Like Protein 11; Brain Neoplasms; Dacarbazine; Extracellular Signal-Regulated MAP Kinases; Fingolimod Hydrochloride; Glioblastoma; Humans; Induction Chemotherapy; Membrane Proteins; Mice; Mice, Nude; Neoplastic Stem Cells; Propylene Glycols; Proto-Oncogene Proteins; Receptors, Lysosphingolipid; Sphingosine; Temozolomide; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2012 |
O(6) -methylguanine-DNA methyltransferase (MGMT) promoter methylation and low MGMT-encoded protein expression as prognostic markers in glioblastoma patients treated with biodegradable carmustine wafer implants after initial surgery followed by radiotherap
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Biomarkers, Tumor; Brain Neoplasms; Carmustine; Chemoradiotherapy; Chemotherapy, Adjuvant; Combined Modality Therapy; Dacarbazine; Disease-Free Survival; DNA Methylation; Female; Glioblastoma; Humans; Male; Middle Aged; O(6)-Methylguanine-DNA Methyltransferase; Prognosis; Promoter Regions, Genetic; Temozolomide | 2012 |
Cotard's syndrome with glioblastoma multiforme.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemoradiotherapy; Combined Modality Therapy; Corpus Callosum; Dacarbazine; Delusions; Depressive Disorder, Major; Glioblastoma; Humans; Male; Middle Aged; Prognosis; Psychotic Disorders; Suicide, Attempted; Syndrome; Temozolomide | 2012 |
Glioblastoma: clinical characteristics, prognostic factors and survival in 492 patients.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Analysis of Variance; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemoradiotherapy; Craniotomy; Dacarbazine; Female; Glioblastoma; Humans; Karnofsky Performance Status; Male; Middle Aged; Multivariate Analysis; Neurosurgical Procedures; Prognosis; Reoperation; Survival; Temozolomide; Young Adult | 2012 |
Extended adjuvant temozolomide for treatment of newly diagnosed glioblastoma multiforme.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemotherapy, Adjuvant; Combined Modality Therapy; Dacarbazine; Disease Progression; Disease-Free Survival; Female; Glioblastoma; Humans; Male; Middle Aged; Prognosis; Retrospective Studies; Temozolomide; Treatment Outcome; Young Adult | 2012 |
The effects of temozolomide delivered by prolonged intracerebral microinfusion against the rat brainstem GBM allograft model.
Topics: Animals; Antineoplastic Agents, Alkylating; Brain Neoplasms; Brain Stem; Cell Line, Tumor; Dacarbazine; Disease Models, Animal; Drug Delivery Systems; Feasibility Studies; Female; Glioblastoma; Infusions, Intraventricular; Microinjections; Rats; Rats, Inbred F344; Survival Rate; Temozolomide; Transplantation, Homologous; Treatment Outcome | 2012 |
Blood glutamate scavengers prolong the survival of rats and mice with brain-implanted gliomas.
Topics: Animals; Antineoplastic Agents, Alkylating; Aspartate Aminotransferases; Brain; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Dacarbazine; Glioma; Glutamic Acid; Humans; Male; Mice; Mice, Nude; Oxaloacetic Acid; Rats; Rats, Sprague-Dawley; Temozolomide; Tumor Burden | 2012 |
Dose dense 1 week on/1 week off temozolomide in recurrent glioma: a retrospective study.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Disease-Free Survival; Drug Administration Schedule; Female; Glioma; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Retrospective Studies; Temozolomide; Treatment Outcome | 2012 |
Twice-daily dosing of temozolomide in combination with fotemustine for the treatment of patients with refractory glioblastoma.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Dacarbazine; Drug Administration Schedule; Female; Glioblastoma; Humans; Male; Middle Aged; Nitrosourea Compounds; Organophosphorus Compounds; Temozolomide | 2012 |
Impact of antiepileptic drugs on thrombocytopenia in glioblastoma patients treated with standard chemoradiotherapy.
Topics: Anticonvulsants; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemoradiotherapy; Dacarbazine; Epilepsy; Female; Glioblastoma; Humans; Male; Middle Aged; Neoplasm Grading; Prognosis; Prospective Studies; Survival Rate; Temozolomide; Thrombocytopenia | 2012 |
MGMT gene promoter methylation as a potent prognostic factor in glioblastoma treated with temozolomide-based chemoradiotherapy: a single-institution study.
Topics: Adult; Age Factors; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Disease-Free Survival; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Female; Glioblastoma; Humans; Male; Middle Aged; Multivariate Analysis; Prognosis; Promoter Regions, Genetic; Radiotherapy, Conformal; Reoperation; Retrospective Studies; Temozolomide; Tumor Suppressor Proteins | 2012 |
Proton and carbon ion radiotherapy for primary brain tumors delivered with active raster scanning at the Heidelberg Ion Therapy Center (HIT): early treatment results and study concepts.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Brain Neoplasms; Carbon; Child; Combined Modality Therapy; Dacarbazine; Female; Glioma; Humans; Ions; Male; Meningioma; Middle Aged; Proton Therapy; Radiotherapy; Radiotherapy Planning, Computer-Assisted; Temozolomide; Young Adult | 2012 |
Superselective intra-arterial cerebral infusion of novel agents after blood-brain disruption for the treatment of recurrent glioblastoma multiforme: a technical case series.
Topics: Adult; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Bevacizumab; Blood-Brain Barrier; Brain Neoplasms; Cetuximab; Dacarbazine; Female; Glioblastoma; Humans; Infusions, Intra-Arterial; Male; Mannitol; Middle Aged; Neoplasm Recurrence, Local; Prognosis; Temozolomide; Treatment Outcome | 2012 |
Successful pregnancy and delivery after concomitant temozolomide and radiotherapy treatment of glioblastoma multiforme.
Topics: Adult; Antineoplastic Agents; Brain Neoplasms; Chemoradiotherapy; Dacarbazine; Female; Glioblastoma; Humans; Pregnancy; Pregnancy Complications, Neoplastic; Pregnancy Outcome; Temozolomide | 2012 |
Expression of O⁶-methylguanine DNA methyltransferase (MGMT) and immunohistochemical analysis of 12 pineal parenchymal tumors.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; Female; Humans; Immunohistochemistry; Ki-67 Antigen; Male; Middle Aged; Neurofilament Proteins; Pineal Gland; Pinealoma; Synaptophysin; Temozolomide; Tumor Suppressor Proteins; Young Adult | 2012 |
Smac mimetic sensitizes glioblastoma cells to Temozolomide-induced apoptosis in a RIP1- and NF-κB-dependent manner.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Apoptosis Regulatory Proteins; Biomimetic Materials; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; Down-Regulation; Drug Synergism; Glioblastoma; Humans; Inhibitor of Apoptosis Proteins; Intracellular Signaling Peptides and Proteins; Mitochondrial Proteins; NF-kappa B; Nuclear Pore Complex Proteins; Oligopeptides; Prognosis; RNA-Binding Proteins; Temozolomide | 2013 |
SSBP2 variants are associated with survival in glioblastoma patients.
Topics: Brain Neoplasms; Dacarbazine; DNA-Binding Proteins; Female; Genome-Wide Association Study; Glioblastoma; Humans; Male; Middle Aged; Polymorphism, Single Nucleotide; Prognosis; Temozolomide | 2012 |
Paradoxical relationship between the degree of EGFR amplification and outcome in glioblastomas.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Biomarkers, Tumor; Brain Neoplasms; Dacarbazine; Drug Resistance, Neoplasm; Female; Gene Amplification; Genes, erbB-1; Glioblastoma; Humans; Immunohistochemistry; In Situ Hybridization, Fluorescence; Kaplan-Meier Estimate; Male; Middle Aged; Polymerase Chain Reaction; Prognosis; Temozolomide; Young Adult | 2012 |
Temozolomide loaded PLGA-based superparamagnetic nanoparticles for magnetic resonance imaging and treatment of malignant glioma.
Topics: Animals; Antineoplastic Agents, Alkylating; Biological Transport; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Chemistry, Pharmaceutical; Contrast Media; Dacarbazine; Delayed-Action Preparations; Dose-Response Relationship, Drug; Drug Carriers; Glioma; Kinetics; Lactic Acid; Light; Magnetic Resonance Imaging; Magnetite Nanoparticles; Microscopy, Electron, Transmission; Microscopy, Fluorescence; Nanomedicine; Particle Size; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polysorbates; Rats; Scattering, Radiation; Solubility; Spectrophotometry, Atomic; Technology, Pharmaceutical; Temozolomide | 2012 |
Rational incorporation of selenium into temozolomide elicits superior antitumor activity associated with both apoptotic and autophagic cell death.
Topics: Animals; Antineoplastic Agents, Alkylating; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Brain Neoplasms; Calpain; Cell Line, Tumor; Dacarbazine; Glioma; Humans; Male; Melanoma; Membrane Proteins; Mice; Mice, Inbred BALB C; Mice, Nude; Selenium; Skin Neoplasms; Temozolomide; Xenograft Model Antitumor Assays | 2012 |
Radiotherapy with concurrent or sequential temozolomide in elderly patients with glioblastoma multiforme.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Female; Glioblastoma; Humans; Male; Middle Aged; Retrospective Studies; Survival Rate; Temozolomide; Treatment Outcome | 2012 |
High-dose methotrexate and temozolomide associated with intrathecal liposomal cytarabine for the treatment of primary or secondary central nervous system lymphoma: a preliminary experience.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Central Nervous System Neoplasms; Cytarabine; Dacarbazine; Female; Humans; Lymphoma; Male; Methotrexate; Middle Aged; Nervous System; Temozolomide | 2012 |
MicroRNA-21 inhibitor sensitizes human glioblastoma U251 stem cells to chemotherapeutic drug temozolomide.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; Glioblastoma; Humans; MicroRNAs; Temozolomide | 2012 |
DW-MRI as a biomarker to compare therapeutic outcomes in radiotherapy regimens incorporating temozolomide or gemcitabine in glioblastoma.
Topics: Animals; Antineoplastic Agents, Alkylating; Biomarkers; Brain Neoplasms; Cell Line; Chemoradiotherapy; Dacarbazine; Deoxycytidine; Diffusion Magnetic Resonance Imaging; Drug Screening Assays, Antitumor; Gemcitabine; Glioblastoma; Humans; Kaplan-Meier Estimate; Mice; Mice, Transgenic; Neoplasms, Experimental; Radiation-Sensitizing Agents; Temozolomide; Treatment Outcome; Tumor Burden | 2012 |
Radiotherapy and temozolomide in anaplastic astrocytoma: a retrospective multicenter study by the Central Nervous System Study Group of AIRO (Italian Association of Radiation Oncology).
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemoradiotherapy; Dacarbazine; Female; Follow-Up Studies; Humans; Male; Middle Aged; Oligodendroglioma; Radiotherapy Dosage; Retrospective Studies; Survival Rate; Temozolomide; Treatment Outcome; Young Adult | 2012 |
Up-regulation of endogenous PML induced by a combination of interferon-beta and temozolomide enhances p73/YAP-mediated apoptosis in glioblastoma.
Topics: Adaptor Proteins, Signal Transducing; Apoptosis; Base Sequence; Blotting, Western; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; DNA Primers; DNA-Binding Proteins; Glioblastoma; Humans; Interferon-beta; Nuclear Proteins; Phosphoproteins; Promyelocytic Leukemia Protein; Real-Time Polymerase Chain Reaction; Temozolomide; Transcription Factors; Tumor Protein p73; Tumor Suppressor Proteins; Up-Regulation; YAP-Signaling Proteins | 2012 |
Efficacy of clinically relevant temozolomide dosing schemes in glioblastoma cancer stem cell lines.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; Drug Resistance, Neoplasm; Flow Cytometry; Glioblastoma; Humans; Neoplastic Stem Cells; Temozolomide; Tumor Stem Cell Assay; Tumor Suppressor Proteins | 2012 |
Distinct molecular mechanisms of acquired resistance to temozolomide in glioblastoma cells.
Topics: Antineoplastic Agents, Alkylating; Blotting, Western; Brain Neoplasms; Cell Cycle; Cell Line, Tumor; Cell Survival; Chromatin; Dacarbazine; DNA Mismatch Repair; DNA Modification Methylases; DNA Mutational Analysis; DNA Repair; DNA Repair Enzymes; DNA Replication; Drug Resistance, Neoplasm; Flow Cytometry; Gene Silencing; Genes, Reporter; Glioblastoma; Humans; p21-Activated Kinases; Polymerase Chain Reaction; RNA Interference; Temozolomide; Tumor Stem Cell Assay; Tumor Suppressor Proteins | 2012 |
miR-181d: a predictive glioblastoma biomarker that downregulates MGMT expression.
Topics: Antineoplastic Agents, Alkylating; Biomarkers, Tumor; Brain Neoplasms; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Immunoblotting; Luciferases; MicroRNAs; Oligonucleotide Array Sequence Analysis; Prognosis; Survival Rate; Temozolomide; Tumor Suppressor Proteins | 2012 |
Prognosis of pediatric high-grade gliomas with temozolomide treatment: a retrospective, multicenter study.
Topics: Adolescent; Antineoplastic Agents, Alkylating; Brain Neoplasms; Child; Child, Preschool; Dacarbazine; Female; Follow-Up Studies; Glioma; Humans; Male; Prognosis; Proportional Hazards Models; Retrospective Studies; Survival Analysis; Temozolomide; Treatment Outcome | 2012 |
Treatment of elderly patients with glioblastoma.
Topics: Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Dacarbazine; Female; Humans; Male; Temozolomide | 2012 |
A retrospective pooled analysis of response patterns and risk factors in recurrent malignant glioma patients receiving a nitrosourea-based chemotherapy.
Topics: Adult; Aged; Brain Neoplasms; Dacarbazine; Female; Glioma; Humans; Logistic Models; Male; Middle Aged; Multivariate Analysis; Neoplasm Recurrence, Local; Nitrosourea Compounds; Organophosphorus Compounds; Retrospective Studies; Risk Factors; Temozolomide; Time Factors; Treatment Failure | 2012 |
Intracranial MEMS based temozolomide delivery in a 9L rat gliosarcoma model.
Topics: Animals; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Drug Delivery Systems; Equipment Design; Female; Gliosarcoma; Rats; Rats, Inbred F344; Temozolomide | 2012 |
Integrin α5β1 plays a critical role in resistance to temozolomide by interfering with the p53 pathway in high-grade glioma.
Topics: Animals; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; Drug Resistance, Neoplasm; Glioblastoma; Humans; Imidazoles; Integrin alpha5beta1; Mice; Piperazines; Temozolomide; Treatment Outcome; Tumor Suppressor Protein p53 | 2012 |
The impact of bevacizumab on temozolomide concentrations in intracranial U87 gliomas.
Topics: Animals; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Bevacizumab; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; Drug Interactions; Extracellular Fluid; Glioma; Humans; Male; Metabolic Clearance Rate; Microdialysis; Rats; Rats, Nude; Temozolomide; Time Factors | 2012 |
Change in platelet levels during radiotherapy with concurrent and adjuvant temozolomide for the treatment of glioblastoma: a novel prognostic factor for survival.
Topics: Antineoplastic Agents, Alkylating; Blood Platelets; Brain Neoplasms; Chemotherapy, Adjuvant; Combined Modality Therapy; Dacarbazine; Female; Glioblastoma; Humans; Male; Middle Aged; Platelet Count; Prognosis; Retrospective Studies; Survival Rate; Temozolomide; Treatment Outcome | 2012 |
Waiting times before initiation of radiotherapy might not affect outcomes for patients with glioblastoma: a French retrospective analysis of patients treated in the era of concomitant temozolomide and radiotherapy.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemoradiotherapy; Chemotherapy, Adjuvant; Dacarbazine; Female; Follow-Up Studies; France; Glioblastoma; Humans; Male; Middle Aged; Prognosis; Radiotherapy Dosage; Retrospective Studies; Survival Rate; Temozolomide; Time Factors; Waiting Lists | 2012 |
Resection of gliomas in the cingulate gyrus: functional outcome and survival.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Female; Glioma; Gyrus Cinguli; Humans; Karnofsky Performance Status; Magnetic Resonance Imaging; Male; Middle Aged; Neurosurgical Procedures; Regression Analysis; Retrospective Studies; Survival Analysis; Temozolomide; Treatment Outcome; Young Adult | 2012 |
Initial treatment patterns over time for anaplastic oligodendroglial tumors.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemoradiotherapy; Chromosomes, Human, Pair 1; Chromosomes, Human, Pair 19; Dacarbazine; Female; Follow-Up Studies; Gene Deletion; Humans; International Agencies; Male; Middle Aged; Oligodendroglioma; Radiotherapy Dosage; Retrospective Studies; Survival Rate; Temozolomide; Treatment Outcome; Young Adult | 2012 |
Combination hyperbaric oxygen and temozolomide therapy in C6 rat glioma model.
Topics: Animals; Antineoplastic Agents, Alkylating; Apoptosis; Brain Neoplasms; Cell Line, Tumor; Combined Modality Therapy; Dacarbazine; Disease Models, Animal; Drug Evaluation, Preclinical; Glioblastoma; Glioma; Hyperbaric Oxygenation; Rats; Rats, Wistar; Temozolomide | 2012 |
Radiotherapy and concomitant temozolomide may improve survival of elderly patients with glioblastoma.
Topics: Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Dose Fractionation, Radiation; Female; Geriatrics; Glioblastoma; Humans; Longitudinal Studies; Male; Retrospective Studies; Sex Factors; Survival Rate; Temozolomide; Treatment Outcome | 2012 |
Late and prolonged pseudoprogression in glioblastoma after treatment with lomustine and temozolomide.
Topics: Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Chemotherapy, Adjuvant; Contrast Media; Dacarbazine; Disease Progression; Fatal Outcome; Female; Gadolinium; Glioblastoma; Humans; Lomustine; Magnetic Resonance Imaging; Male; Middle Aged; Radiotherapy, Adjuvant; Temozolomide; Treatment Outcome | 2012 |
Valproic acid downregulates the expression of MGMT and sensitizes temozolomide-resistant glioma cells.
Topics: Animals; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; Down-Regulation; Drug Resistance, Neoplasm; Drug Synergism; Gene Expression Regulation, Neoplastic; Glioma; Humans; Mice; Temozolomide; Tumor Suppressor Proteins; Valproic Acid; Xenograft Model Antitumor Assays | 2012 |
Safety and efficacy of Gliadel wafers for newly diagnosed and recurrent glioblastoma.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Carmustine; Dacarbazine; Glioblastoma; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Temozolomide; Treatment Outcome | 2012 |
Bevacizumab for glioblastoma multiforme after traumatic subarachnoid hemorrhage.
Topics: Angiogenesis Inhibitors; Antibodies, Monoclonal, Humanized; Antineoplastic Agents, Alkylating; Bevacizumab; Brain Neoplasms; Dacarbazine; Glioblastoma; Humans; Male; Middle Aged; Subarachnoid Hemorrhage, Traumatic; Temozolomide; Tomography, X-Ray Computed; Ultrasonography, Doppler, Transcranial | 2012 |
Knockdown of CDK6 enhances glioma sensitivity to chemotherapy.
Topics: Animals; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinase 6; Dacarbazine; Drug Resistance, Neoplasm; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Humans; Membrane Proteins; Mice; Oligonucleotide Array Sequence Analysis; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; RNA Interference; Temozolomide; Transcription, Genetic | 2012 |
IDH1 mutation as a potential novel biomarker for distinguishing pseudoprogression from true progression in patients with glioblastoma treated with temozolomide and radiotherapy.
Topics: Adult; Antineoplastic Agents, Alkylating; Biomarkers, Tumor; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Disease Progression; Female; Glioblastoma; Humans; Mutation; Neoplasms, Multiple Primary; Oligodendroglioma; Radiotherapy; Retrospective Studies; Second-Look Surgery; Temozolomide | 2013 |
MicroRNA-21 inhibition enhances in vitro chemosensitivity of temozolomide-resistant glioblastoma cells.
Topics: Antineoplastic Agents, Alkylating; Biomarkers, Tumor; Brain Neoplasms; Cell Line, Tumor; Combined Modality Therapy; Dacarbazine; Genetic Therapy; Glioblastoma; Humans; MicroRNAs; Oligonucleotides, Antisense; Temozolomide; Transfection | 2012 |
Hyperoxia resensitizes chemoresistant human glioblastoma cells to temozolomide.
Topics: Antineoplastic Agents, Alkylating; Apoptosis; Blotting, Western; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; Drug Resistance, Neoplasm; Glioblastoma; Humans; Hyperoxia; Mitogen-Activated Protein Kinase Kinases; Temozolomide | 2012 |
Radiation necrosis of a high-grade glioma.
Topics: Antineoplastic Agents, Alkylating; Antineoplastic Agents, Phytogenic; Brain Neoplasms; Dacarbazine; Glioma; Humans; Magnetic Resonance Angiography; Male; Middle Aged; Necrosis; Paclitaxel; Polyglutamic Acid; Temozolomide | 2012 |
Helping patients make the best decision regarding duration of temozolomide chemotherapy treatment.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Female; Glioblastoma; Humans; Middle Aged; Neurosurgical Procedures; Physician-Patient Relations; Practice Patterns, Physicians'; Radiotherapy; Temozolomide | 2012 |
CXCR4-positive subset of glioma is enriched for cancer stem cells.
Topics: AC133 Antigen; Animals; Antigens, CD; Antineoplastic Agents, Alkylating; Blotting, Western; Brain Neoplasms; Cell Proliferation; Dacarbazine; Fluorescent Antibody Technique; Gamma Rays; Gene Expression Regulation, Neoplastic; Glioma; Glycoproteins; Humans; Immunoenzyme Techniques; Mice; Mice, SCID; Neoplastic Stem Cells; Peptides; Receptors, CXCR4; Temozolomide; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2011 |
Local delivery of slow-releasing temozolomide microspheres inhibits intracranial xenograft glioma growth.
Topics: Animals; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Growth Processes; Cell Line, Tumor; Cell Survival; Dacarbazine; Delayed-Action Preparations; Female; Glioma; Humans; Mice; Mice, Nude; Microspheres; Random Allocation; Temozolomide; Xenograft Model Antitumor Assays | 2012 |
O6-Methylguanine-methyltransferase (MGMT) promoter methylation status in glioma stem-like cells is correlated to temozolomide sensitivity under differentiation-promoting conditions.
Topics: Aged; Algorithms; Brain Neoplasms; Cell Differentiation; Cell Line, Tumor; Dacarbazine; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Female; Glioma; Humans; Inhibitory Concentration 50; Male; Microscopy, Confocal; Middle Aged; Neoplastic Stem Cells; Promoter Regions, Genetic; Sequence Analysis, DNA; Temozolomide; Tumor Suppressor Proteins | 2012 |
Elderly people with glioblastoma.
Topics: Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Dacarbazine; Female; Humans; Male | 2012 |
Elderly people with glioblastoma.
Topics: Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Dacarbazine; Female; Humans; Male | 2012 |
A restricted cell population propagates glioblastoma growth after chemotherapy.
Topics: Animals; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Proliferation; Cell Tracking; Dacarbazine; Disease Models, Animal; Disease Progression; Female; Ganciclovir; Glioblastoma; Green Fluorescent Proteins; Male; Mice; Mice, Transgenic; Neoplastic Stem Cells; Neural Stem Cells; Temozolomide; Transgenes | 2012 |
Interdisciplinary treatment of glioblastoma: analysis of prognostic factors and treatment results in unselected patients.
Topics: Adult; Aged; Aged, 80 and over; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Female; Glioblastoma; Humans; Male; Middle Aged; Proportional Hazards Models; Radiotherapy, Conformal; Survival Rate; Temozolomide | 2012 |
A population-based study on the effect of temozolomide in the treatment of glioblastoma multiforme.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Female; Follow-Up Studies; Glioblastoma; Humans; Male; Middle Aged; Norway; Prognosis; Prospective Studies; Radiotherapy Dosage; Registries; Survival Rate; Temozolomide | 2012 |
CT322, a VEGFR-2 antagonist, demonstrates anti-glioma efficacy in orthotopic brain tumor model as a single agent or in combination with temozolomide and radiation therapy.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cell Line, Tumor; Chemoradiotherapy; Dacarbazine; Fibronectins; Glioma; Humans; Male; Mice; Mice, Inbred NOD; Mice, SCID; Peptide Fragments; Temozolomide; Vascular Endothelial Growth Factor Receptor-2; Xenograft Model Antitumor Assays | 2012 |
Presentation, management, and outcome of elderly patients with newly-diagnosed anaplastic astrocytoma.
Topics: Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Disease Management; Female; Humans; Male; Middle Aged; Prognosis; Retrospective Studies; Survival Rate; Temozolomide | 2012 |
Glioblastoma therapy in the elderly: one age does not fit all.
Topics: Brain Neoplasms; Dacarbazine; Female; Glioblastoma; Humans; Male; Temozolomide | 2012 |
Protracted low dose of oral vinorelbine and temozolomide with whole-brain radiotherapy in the treatment for breast cancer patients with brain metastases.
Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Breast Neoplasms; Combined Modality Therapy; Cranial Irradiation; Dacarbazine; Female; Humans; Middle Aged; Quality of Life; Temozolomide; Vinblastine; Vinorelbine | 2012 |
The synergistic therapeutic effect of temozolomide and hyperbaric oxygen on glioma U251 cell lines is accompanied by alterations in vascular endothelial growth factor and multidrug resistance-associated protein-1 levels.
Topics: Antineoplastic Agents, Alkylating; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Brain Neoplasms; Cell Cycle; Cell Line, Tumor; Dacarbazine; DNA Damage; Drug Therapy, Combination; Enzyme-Linked Immunosorbent Assay; Glioma; Humans; Hyperbaric Oxygenation; Temozolomide; Vascular Endothelial Growth Factor A | 2012 |
Prognostic relevance of c-Myc and BMI1 expression in patients with glioblastoma.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Female; Glioblastoma; Humans; Male; Middle Aged; Nuclear Proteins; Polycomb Repressive Complex 1; Prognosis; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-myc; Repressor Proteins; Survival Rate; Temozolomide; Treatment Outcome | 2012 |
Cancer: Resolving the stem-cell debate.
Topics: Animals; Brain Neoplasms; Cell Lineage; Cell Tracking; Dacarbazine; Female; Glioblastoma; Humans; Male; Neoplastic Stem Cells; Skin Neoplasms; Temozolomide | 2012 |
Prognosis of patients with multifocal glioblastoma: a case-control study.
Topics: Aged; Antineoplastic Agents; Brain Neoplasms; Case-Control Studies; Cohort Studies; Combined Modality Therapy; Dacarbazine; Glioblastoma; Humans; Kaplan-Meier Estimate; Middle Aged; Neoplasms, Multiple Primary; Neurosurgical Procedures; Prognosis; Radiotherapy; Retrospective Studies; Survival Rate; Temozolomide; Treatment Outcome | 2012 |
Perillyl alcohol for the treatment of temozolomide-resistant gliomas.
Topics: Administration, Intranasal; Animals; Brain Neoplasms; Cell Death; Cell Line, Tumor; Cell Proliferation; Cytokines; Dacarbazine; Drug Resistance, Neoplasm; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Glioma; Humans; Mice; Monoterpenes; Nelfinavir; Neoplasm Invasiveness; Neovascularization, Pathologic; Pyrazoles; Sulfonamides; Temozolomide; Xenograft Model Antitumor Assays | 2012 |
Potentiation of etoposide and temozolomide cytotoxicity by curcumin and turmeric force™ in brain tumor cell lines.
Topics: Antineoplastic Agents; Antineoplastic Agents, Alkylating; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Cerebellar Neoplasms; Curcuma; Curcumin; Dacarbazine; Dose-Response Relationship, Drug; Drug Synergism; Etoposide; Glioblastoma; Humans; Inhibitory Concentration 50; Medulloblastoma; Phytotherapy; Plant Extracts; Plants, Medicinal; Rhizome; Temozolomide | 2012 |
The T genotype of the MGMT C>T (rs16906252) enhancer single-nucleotide polymorphism (SNP) is associated with promoter methylation and longer survival in glioblastoma patients.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cohort Studies; Combined Modality Therapy; Dacarbazine; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Female; Genotype; Glioblastoma; Humans; Male; Middle Aged; Polymorphism, Single Nucleotide; Promoter Regions, Genetic; Retrospective Studies; Survival Analysis; Temozolomide; Transfection; Tumor Suppressor Proteins; Young Adult | 2013 |
Methylation mediated silencing of miR-23b expression and its role in glioma stem cells.
Topics: Antineoplastic Agents; Azacitidine; Brain Neoplasms; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Dacarbazine; Decitabine; Down-Regulation; Epigenesis, Genetic; Gene Silencing; Glioma; Humans; Methylation; MicroRNAs; Neoplastic Stem Cells; Promoter Regions, Genetic; Temozolomide | 2012 |
Abbreviated course of radiation therapy with concurrent temozolomide for high-grade glioma in patients of advanced age or poor functional status.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemoradiotherapy; Dacarbazine; Disease Progression; Dose Fractionation, Radiation; Female; Follow-Up Studies; Glioblastoma; Humans; Karnofsky Performance Status; Male; Middle Aged; Neoplasm Grading; Prognosis; Quality of Life; Survival Rate; Temozolomide | 2012 |
Fasting enhances the response of glioma to chemo- and radiotherapy.
Topics: Animals; Antineoplastic Agents, Alkylating; Astrocytoma; Blood Glucose; Body Weight; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; Fasting; Glioblastoma; Glioma; Insulin-Like Growth Factor I; Luminescence; Male; Mice; Mice, Inbred C57BL; Neoplasm Transplantation; Rats; Temozolomide | 2012 |
Decision making and management of gliomas: practical considerations.
Topics: Aged; Astrocytoma; Biomarkers, Tumor; Brain Neoplasms; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; Glioblastoma; Humans; Isocitrate Dehydrogenase; Meta-Analysis as Topic; Oligodendroglioma; Temozolomide; Tumor Suppressor Proteins | 2012 |
A review of dose-dense temozolomide alone and in combination with bevacizumab in patients with first relapse of glioblastoma.
Topics: Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Brain Neoplasms; Clinical Trials as Topic; Dacarbazine; Dose-Response Relationship, Drug; Glioblastoma; Humans; Recurrence; Temozolomide | 2012 |
Survival over 6 years in a patient with brain metastases from melanoma treated with temozolomide.
Topics: Antineoplastic Agents, Alkylating; Brain; Brain Neoplasms; Dacarbazine; Disease-Free Survival; Female; Humans; Melanoma; Middle Aged; Temozolomide; Treatment Outcome | 2012 |
Prime time for molecular marker diagnostics in neuro-oncology.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Glioblastoma; Humans; Prognosis; Promoter Regions, Genetic; Radiotherapy; Randomized Controlled Trials as Topic; Temozolomide; Treatment Outcome; Tumor Suppressor Proteins | 2012 |
Efficacy of temozolomide in a central nervous system relapse of neuroblastoma with O 6 -methylguanine methyltransferase (MGMT) promoter methylation.
Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Camptothecin; Child, Preschool; Combined Modality Therapy; Dacarbazine; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Female; Humans; Irinotecan; Neoplasm Recurrence, Local; Neuroblastoma; Prognosis; Promoter Regions, Genetic; Stem Cell Transplantation; Temozolomide; Transplantation, Autologous; Tumor Suppressor Proteins | 2013 |
Disulfiram, a drug widely used to control alcoholism, suppresses the self-renewal of glioblastoma and over-rides resistance to temozolomide.
Topics: Alcohol Deterrents; Antineoplastic Agents, Alkylating; Apoptosis; Blotting, Western; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Dacarbazine; Disulfiram; Drug Resistance, Neoplasm; Glioblastoma; Humans; Immunoenzyme Techniques; Temozolomide | 2012 |
ATM inhibitor KU-55933 increases the TMZ responsiveness of only inherently TMZ sensitive GBM cells.
Topics: Animals; Antineoplastic Agents, Alkylating; Apoptosis; Ataxia Telangiectasia Mutated Proteins; Blotting, Western; Brain Neoplasms; Cell Cycle Proteins; Cell Division; Cell Proliferation; Dacarbazine; DNA Damage; DNA-Binding Proteins; Drug Resistance, Neoplasm; Flow Cytometry; G2 Phase; Glioblastoma; Humans; Immunoenzyme Techniques; Mice; Morpholines; Neurons; Protein Serine-Threonine Kinases; Pyrones; Temozolomide; Tumor Cells, Cultured; Tumor Stem Cell Assay; Tumor Suppressor Proteins | 2012 |
Failure pattern following complete resection plus radiotherapy and temozolomide is at the resection margin in patients with glioblastoma.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Female; Glioblastoma; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Radiotherapy Dosage; Temozolomide; Treatment Failure | 2013 |
Mibefradil, a novel therapy for glioblastoma multiforme: cell cycle synchronization and interlaced therapy in a murine model.
Topics: Animals; Antineoplastic Agents, Alkylating; Brain Neoplasms; Calcium Channel Blockers; Cell Cycle; Dacarbazine; Disease Models, Animal; Drug Administration Schedule; Drug Therapy, Combination; Glioblastoma; Humans; Kaplan-Meier Estimate; Mibefradil; Mice; Neoplasm Transplantation; Skin Neoplasms; Temozolomide; Time Factors; Xenograft Model Antitumor Assays | 2013 |
Increased xCT expression correlates with tumor invasion and outcome in patients with glioblastomas.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Amino Acid Transport System y+; Antineoplastic Agents, Alkylating; Biomarkers, Tumor; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Disease-Free Survival; DNA Modification Methylases; DNA Repair Enzymes; Excitatory Amino Acid Transporter 2; Female; Glioblastoma; Glutamate Plasma Membrane Transport Proteins; Humans; Immunohistochemistry; Isocitrate Dehydrogenase; Kaplan-Meier Estimate; Karnofsky Performance Status; Magnetic Resonance Imaging; Male; Middle Aged; Neoplasm Invasiveness; Neuropsychological Tests; Prognosis; Survival Analysis; Temozolomide; Treatment Outcome; Tumor Suppressor Proteins; Young Adult | 2013 |
Rapid desensitization with temozolomide in patients with delayed maculopapular rash.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Desensitization, Immunologic; Drug Hypersensitivity; Exanthema; Female; Glioma; Humans; Hypersensitivity, Delayed; Immune Tolerance; Skin Tests; Temozolomide | 2012 |
Relapse of herpes encephalitis induced by temozolomide-based chemoradiation in a patient with malignant glioma.
Topics: Adult; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemoradiotherapy; Dacarbazine; Encephalitis, Herpes Simplex; Glioma; Humans; Magnetic Resonance Imaging; Male; Recurrence; Temozolomide; Virus Activation | 2013 |
Sarcomatous evolution of oligodendroglioma ("oligosarcoma"): confirmatory report of an uncommon pattern of malignant progression in oligodendroglial tumors.
Topics: Adult; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chromosome Deletion; Chromosomes, Human, Pair 1; Chromosomes, Human, Pair 19; Combined Modality Therapy; Dacarbazine; Disease Progression; Gliosarcoma; Humans; Isocitrate Dehydrogenase; Male; Mutation; Neoplasm Recurrence, Local; Neoplasms, Second Primary; Oligodendroglioma; Temozolomide | 2012 |
Overexpression of isocitrate dehydrogenase mutant proteins renders glioma cells more sensitive to radiation.
Topics: Antineoplastic Agents, Alkylating; Apoptosis; Blotting, Western; Brain Neoplasms; Cell Adhesion; Cell Movement; Cell Proliferation; Dacarbazine; Electromagnetic Radiation; Flow Cytometry; Fluorescent Antibody Technique; Gene Expression Regulation, Neoplastic; Glioma; Humans; Isocitrate Dehydrogenase; Mutant Proteins; Mutation; Radiation Tolerance; Reactive Oxygen Species; Temozolomide; Tumor Cells, Cultured | 2013 |
High levels of phosphorylated MAP kinase are associated with poor survival among patients with glioblastoma during the temozolomide era.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; ErbB Receptors; Female; Follow-Up Studies; Gene Amplification; Glioblastoma; Humans; Immunoenzyme Techniques; Male; Middle Aged; Mitogen-Activated Protein Kinases; Phosphorylation; Prognosis; PTEN Phosphohydrolase; Retrospective Studies; Survival Rate; Temozolomide; Young Adult | 2013 |
Detection of glioblastoma response to temozolomide combined with bevacizumab based on μMRI and μPET imaging reveals [18F]-fluoro-L-thymidine as an early and robust predictive marker for treatment efficacy.
Topics: Animals; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Biomarkers; Brain Neoplasms; Dacarbazine; Fluorodeoxyglucose F18; Glioblastoma; Humans; Immunoenzyme Techniques; Magnetic Resonance Imaging; Positron-Emission Tomography; Radiopharmaceuticals; Rats; Rats, Nude; Survival Rate; Temozolomide; Treatment Outcome; Tumor Burden; Xenograft Model Antitumor Assays | 2013 |
Bevacizumab-induced oral mucositis in background of cutaneous plaque-type psoriasis.
Topics: Adult; Angiogenesis Inhibitors; Antibodies, Monoclonal, Humanized; Antineoplastic Agents, Alkylating; Bevacizumab; Brain Neoplasms; Dacarbazine; Female; Humans; Neovascularization, Pathologic; Psoriasis; Stomatitis; Temozolomide | 2012 |
Treatment options in elderly patients with glioblastoma.
Topics: Brain Neoplasms; Dacarbazine; Female; Glioblastoma; Humans; Male | 2012 |
Targeted nitric oxide delivery preferentially induces glioma cell chemosensitivity via altered p53 and O(6) -methylguanine-DNA methyltransferase activity.
Topics: Antineoplastic Agents; Brain Neoplasms; Carmustine; Dacarbazine; Drug Resistance, Neoplasm; Glioblastoma; Humans; Nitric Oxide; O(6)-Methylguanine-DNA Methyltransferase; Scorpion Venoms; Temozolomide; Tumor Suppressor Protein p53 | 2013 |
Knockdown of Nrf2 enhances autophagy induced by temozolomide in U251 human glioma cell line.
Topics: Antineoplastic Agents, Alkylating; Apoptosis; Autophagy; Blotting, Western; Brain Neoplasms; Dacarbazine; Down-Regulation; Flow Cytometry; Fluorescent Antibody Technique; Glioma; Humans; Microscopy, Electron, Transmission; NF-E2-Related Factor 2; RNA, Small Interfering; Temozolomide; Tumor Cells, Cultured | 2013 |
Hypofractionated stereotactic radiotherapy and continuous low-dose temozolomide in patients with recurrent or progressive malignant gliomas.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Dihydroxyphenylalanine; Disease-Free Survival; Female; Follow-Up Studies; Glioma; Humans; Karnofsky Performance Status; Male; Middle Aged; Radiosurgery; Retrospective Studies; Temozolomide | 2013 |
Aldehyde dehydrogenase 1A1--a new mediator of resistance to temozolomide in glioblastoma.
Topics: Aged; Aldehyde Dehydrogenase; Aldehyde Dehydrogenase 1 Family; Antineoplastic Agents; Biomarkers, Tumor; Blotting, Western; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; Drug Resistance, Neoplasm; Female; Gene Knockdown Techniques; Glioblastoma; Humans; Immunohistochemistry; Kaplan-Meier Estimate; Male; Middle Aged; Promoter Regions, Genetic; Real-Time Polymerase Chain Reaction; Retinal Dehydrogenase; Temozolomide; Transfection; Tumor Suppressor Proteins | 2012 |
Effective elimination of cancer stem cells by a novel drug combination strategy.
Topics: Adenosine Triphosphate; Animals; Brain Neoplasms; Carmustine; Cell Line, Tumor; Cell Survival; Dacarbazine; DNA Damage; DNA Repair; Drug Combinations; Drug Synergism; Glioblastoma; Glyceraldehyde-3-Phosphate Dehydrogenases; Glycolysis; Humans; Hydrocarbons, Brominated; Hypoxia; Mice; Mice, SCID; Mitochondria; Neoplastic Stem Cells; Propionates; Temozolomide | 2013 |
Neuro-oncology: treatment decisions in elderly patients with glioblastoma.
Topics: Aged; Antineoplastic Agents; Brain Neoplasms; Chemoradiotherapy; Dacarbazine; Glioblastoma; Humans; Middle Aged; Temozolomide | 2012 |
An efficient and practical radiosynthesis of [11C]temozolomide.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Carbon Radioisotopes; Dacarbazine; Molecular Structure; Radiopharmaceuticals; Temozolomide; Tissue Distribution | 2012 |
Equinatoxin II potentiates temozolomide- and etoposide-induced glioblastoma cell death.
Topics: Animals; Antineoplastic Agents; Apoptosis; Blotting, Western; Brain Neoplasms; Cell Line, Tumor; Cnidarian Venoms; Dacarbazine; Drug Synergism; Etoposide; Glioblastoma; Humans; Immunohistochemistry; Magnetic Resonance Imaging; Male; Mice; Mice, Inbred C57BL; Temozolomide | 2012 |
Multimodal magnetic resonance imaging and 18F-L-dihydroxyphenylalanine positron emission tomography in early characterization of pseudoresponse and nonenhancing tumor progression in a pediatric patient with malignant transformation of ganglioglioma treate
Topics: Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Brain Neoplasms; Cell Transformation, Neoplastic; Child, Preschool; Dacarbazine; Dihydroxyphenylalanine; Disease Progression; Female; Fluorine Radioisotopes; Ganglioglioma; Humans; Magnetic Resonance Imaging; Positron-Emission Tomography; Prognosis; Radiopharmaceuticals; Temozolomide | 2013 |
Immunohistochemical molecular gene expression profile of metastatic brain tumor as a potent personalized medicine.
Topics: Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain; Brain Neoplasms; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; ErbB Receptors; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; Male; Middle Aged; Molecular Targeted Therapy; Precision Medicine; Receptor, ErbB-2; Temozolomide; Tumor Suppressor Proteins | 2013 |
Mutant TP53 enhances the resistance of glioblastoma cells to temozolomide by up-regulating O(6)-methylguanine DNA-methyltransferase.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; Drug Resistance, Neoplasm; Gene Knockdown Techniques; Genes, p53; Glioblastoma; Humans; Mutation; O(6)-Methylguanine-DNA Methyltransferase; RNA, Small Interfering; Temozolomide; Up-Regulation | 2013 |
Combination of paclitaxel thermal gel depot with temozolomide and radiotherapy significantly prolongs survival in an experimental rodent glioma model.
Topics: Analysis of Variance; Animals; Antineoplastic Agents, Phytogenic; Brain Neoplasms; Dacarbazine; Disease Models, Animal; Drug Delivery Systems; Drug Therapy, Combination; Female; Gels; Glioma; Humans; Neoplasm Transplantation; Paclitaxel; Rats; Rats, Inbred F344; Survival Analysis; Temozolomide | 2013 |
Distance to the neurooncological center: a negative prognostic factor in patients with glioblastoma multiforme. An epidemiological study.
Topics: Adult; Aged; Aged, 80 and over; Brain Neoplasms; Chemotherapy, Adjuvant; Cohort Studies; Dacarbazine; Female; Glioblastoma; Health Services Accessibility; Humans; Male; Middle Aged; Prognosis; Retrospective Studies; Survival Rate; Temozolomide; Young Adult | 2012 |
Malignant glioma with angiocentric features.
Topics: Adolescent; Antineoplastic Agents, Alkylating; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Glioma; Humans; Magnetic Resonance Imaging; Male; Necrosis; Neoplasm Recurrence, Local; Nervous System Diseases; Temozolomide | 2013 |
Pharmacologic blockade of FAK autophosphorylation decreases human glioblastoma tumor growth and synergizes with temozolomide.
Topics: Animals; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dacarbazine; Female; Focal Adhesion Protein-Tyrosine Kinases; Glioblastoma; Humans; Mice; Mice, Knockout; Mice, Nude; Phosphorylation; Protein Kinase Inhibitors; Random Allocation; Temozolomide; Xenograft Model Antitumor Assays | 2013 |
Management options for metastatic melanoma in the era of novel therapies: a primer for the practicing dermatologist: part II: Management of stage IV disease.
Topics: Antibodies, Monoclonal; Antineoplastic Agents; Brain Neoplasms; Dacarbazine; Humans; Immunologic Factors; Indoles; Interleukin-2; Ipilimumab; Melanoma; Neoplasm Staging; Palliative Care; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-kit; Radiosurgery; raf Kinases; Skin Neoplasms; Sulfonamides; Vemurafenib | 2013 |
MGMT promoter methylation status and MGMT and CD133 immunohistochemical expression as prognostic markers in glioblastoma patients treated with temozolomide plus radiotherapy.
Topics: AC133 Antigen; Adult; Aged; Aged, 80 and over; Antigens, CD; Biomarkers, Tumor; Brain Neoplasms; Dacarbazine; Disease-Free Survival; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Female; Glioblastoma; Glycoproteins; Humans; Immunohistochemistry; Male; Middle Aged; Neoplasm Recurrence, Local; Peptides; Polymerase Chain Reaction; Prognosis; Promoter Regions, Genetic; Temozolomide; Treatment Outcome; Tumor Suppressor Proteins; Young Adult | 2012 |
Inhibition of GSH synthesis potentiates temozolomide-induced bystander effect in glioblastoma.
Topics: Animals; Antineoplastic Agents, Alkylating; Apoptosis; Blotting, Western; Brain Neoplasms; Bystander Effect; Catalase; Cell Proliferation; Culture Media, Conditioned; Dacarbazine; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Drug Resistance, Neoplasm; Female; Glioblastoma; Glutathione; Humans; Immunoenzyme Techniques; Mice; Mice, Inbred BALB C; Real-Time Polymerase Chain Reaction; RNA, Small Interfering; Superoxide Dismutase; Temozolomide; Tumor Cells, Cultured; Tumor Suppressor Proteins; Xenograft Model Antitumor Assays | 2013 |
DARPP32, STAT5 and STAT3 mRNA expression ratios in glioblastomas are associated with patient outcome.
Topics: Apoptosis; Brain Neoplasms; Dacarbazine; Dopamine and cAMP-Regulated Phosphoprotein 32; Female; Glioblastoma; Humans; Inhibitor of Apoptosis Proteins; Male; Middle Aged; Phosphorylation; Proto-Oncogene Proteins c-akt; RNA, Messenger; STAT3 Transcription Factor; STAT5 Transcription Factor; Survivin; Temozolomide | 2013 |
Toxicity and survival in primary glioblastoma patients treated with concomitant plus adjuvant temozolomide versus adjuvant temozolomide: results of a single-institution, retrospective, matched-pair analysis.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemoradiotherapy; Chemoradiotherapy, Adjuvant; Combined Modality Therapy; Dacarbazine; Female; Glioblastoma; Humans; Male; Matched-Pair Analysis; Middle Aged; Prognosis; Retrospective Studies; Survival Rate; Temozolomide | 2013 |
The DNA repair protein ALKBH2 mediates temozolomide resistance in human glioblastoma cells.
Topics: AlkB Homolog 2, Alpha-Ketoglutarate-Dependent Dioxygenase; Antineoplastic Agents, Alkylating; Blotting, Western; Brain Neoplasms; Cell Adhesion; Cell Movement; Cell Proliferation; Dacarbazine; Dioxygenases; DNA Repair Enzymes; Drug Resistance, Neoplasm; Flow Cytometry; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Small Interfering; Temozolomide; Tumor Cells, Cultured; Tumor Stem Cell Assay | 2013 |
Temozolomide use in adult patients with gliosarcoma: an evolving clinical practice.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Female; Gliosarcoma; Humans; Kaplan-Meier Estimate; Longitudinal Studies; Male; Middle Aged; Multivariate Analysis; Retrospective Studies; Temozolomide; Treatment Outcome; Young Adult | 2013 |
Subcellular real-time imaging of the efficacy of temozolomide on cancer cells in the brain of live mice.
Topics: Animals; Apoptosis; Brain Neoplasms; Carcinoma, Lewis Lung; Cell Line, Tumor; Cell Nucleus; Craniotomy; Cytoplasm; Dacarbazine; Diagnostic Imaging; Glioma; Green Fluorescent Proteins; Humans; Luminescent Proteins; Mice; Red Fluorescent Protein; Temozolomide | 2013 |
Quantitative probabilistic functional diffusion mapping in newly diagnosed glioblastoma treated with radiochemotherapy.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemoradiotherapy; Dacarbazine; Diffusion Magnetic Resonance Imaging; Follow-Up Studies; Glioblastoma; Humans; Image Interpretation, Computer-Assisted; Neoplasm Staging; Prognosis; Retrospective Studies; ROC Curve; Survival Rate; Temozolomide | 2013 |
Integration method of 3D MR spectroscopy into treatment planning system for glioblastoma IMRT dose painting with integrated simultaneous boost.
Topics: Brain Neoplasms; Contrast Media; Dacarbazine; Glioblastoma; Humans; Image Processing, Computer-Assisted; Imaging, Three-Dimensional; Magnetic Resonance Spectroscopy; Middle Aged; Radiometry; Radiotherapy Planning, Computer-Assisted; Radiotherapy, Conformal; Radiotherapy, Intensity-Modulated; Recurrence; Temozolomide; Tomography, X-Ray Computed | 2013 |
Exclusion of histiocytes/endothelial cells and using endothelial cells as internal reference are crucial for interpretation of MGMT immunohistochemistry in glioblastoma.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Biomarkers, Tumor; Brain Neoplasms; Child; Child, Preschool; Dacarbazine; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Endothelium, Vascular; Female; Glioblastoma; Histiocytes; Humans; Male; Middle Aged; Predictive Value of Tests; Promoter Regions, Genetic; Staining and Labeling; Survival Rate; Taiwan; Temozolomide; Treatment Outcome; Tumor Suppressor Proteins; Young Adult | 2013 |
Impact of temozolomide on gonadal function in patients with primary malignant brain tumors.
Topics: Adult; Antineoplastic Agents, Alkylating; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Follow-Up Studies; Glioma; Gonadal Steroid Hormones; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Pilot Projects; Prospective Studies; Semen; Sperm Motility; Temozolomide; Time Factors | 2013 |
Response to bevacizumab, irinotecan, and temozolomide in children with relapsed medulloblastoma: a multi-institutional experience.
Topics: Adolescent; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Brain Neoplasms; Camptothecin; Child; Child, Preschool; Dacarbazine; Drug Administration Schedule; Female; Humans; Infant; Irinotecan; Male; Medulloblastoma; Recurrence; Retrospective Studies; Temozolomide; Treatment Outcome | 2013 |
Tetra-O-methyl nordihydroguaiaretic acid, an inhibitor of Sp1-mediated survivin transcription, induces apoptosis and acts synergistically with chemo-radiotherapy in glioblastoma cells.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Brain Neoplasms; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Dacarbazine; Dose-Response Relationship, Drug; Drug Synergism; Female; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Inhibitor of Apoptosis Proteins; Inhibitory Concentration 50; Male; Masoprocol; Mitotic Index; Radiation-Sensitizing Agents; RNA Splicing; RNA, Messenger; Sp1 Transcription Factor; Survivin; Temozolomide; Transcription, Genetic | 2013 |
Performance status during and after radiotherapy plus concomitant and adjuvant temozolomide in elderly patients with glioblastoma multiforme.
Topics: Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemoradiotherapy, Adjuvant; Dacarbazine; Female; Glioblastoma; Humans; Kaplan-Meier Estimate; Karnofsky Performance Status; Male; Prognosis; Radiotherapy; Temozolomide; Treatment Outcome | 2013 |
Engineered drug resistant γδ T cells kill glioblastoma cell lines during a chemotherapy challenge: a strategy for combining chemo- and immunotherapy.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Line, Tumor; Cell Survival; Cells, Cultured; Cytotoxicity, Immunologic; Dacarbazine; Diphosphonates; Drug Resistance, Neoplasm; Flow Cytometry; Genetic Engineering; Genetic Vectors; Glioblastoma; GPI-Linked Proteins; Humans; Imidazoles; Intercellular Signaling Peptides and Proteins; Interleukin-2; Lentivirus; O(6)-Methylguanine-DNA Methyltransferase; Receptors, Antigen, T-Cell, gamma-delta; T-Lymphocytes; Temozolomide; Zoledronic Acid | 2013 |
Combined analysis of O6-methylguanine-DNA methyltransferase protein expression and promoter methylation provides optimized prognostication of glioblastoma outcome.
Topics: Adult; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemoradiotherapy; Dacarbazine; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; DNA, Neoplasm; Female; Follow-Up Studies; Glioblastoma; Humans; Male; Middle Aged; Neoplasm Staging; Polymerase Chain Reaction; Prognosis; Promoter Regions, Genetic; Retrospective Studies; Survival Rate; Temozolomide; Tumor Suppressor Proteins | 2013 |
A pilot study of glioblastoma multiforme in elderly patients: treatments, O-6-methylguanine-DNA methyltransferase (MGMT) methylation status and survival.
Topics: Aged; Aged, 80 and over; Antineoplastic Agents; Biopsy; Brain Neoplasms; Chemoradiotherapy; Cohort Studies; Combined Modality Therapy; Dacarbazine; Female; Glioblastoma; Humans; Kaplan-Meier Estimate; Male; Neurosurgical Procedures; O(6)-Methylguanine-DNA Methyltransferase; Pilot Projects; Prognosis; Survival; Treatment Outcome | 2013 |
[Treatment and prognosis of stage IV alveolar soft part sarcoma].
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Brain Neoplasms; Dacarbazine; Disease-Free Survival; Doxorubicin; Female; Follow-Up Studies; Humans; Ifosfamide; Lower Extremity; Lung Neoplasms; Male; Mesna; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Staging; Particle Accelerators; Remission Induction; Salvage Therapy; Sarcoma, Alveolar Soft Part; Soft Tissue Neoplasms; Survival Rate | 2012 |
Downregulation of Src enhances the cytotoxic effect of temozolomide through AKT in glioma.
Topics: Animals; Apoptosis; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; Down-Regulation; Gene Expression Regulation, Neoplastic; Glioblastoma; Glioma; Humans; Mice; Oncogene Protein v-akt; Signal Transduction; src-Family Kinases; Temozolomide; Xenograft Model Antitumor Assays | 2013 |
In human glioblastomas transcript elongation by alternative polyadenylation and miRNA targeting is a potent mechanism of MGMT silencing.
Topics: 3' Untranslated Regions; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Culture Techniques; Cell Line, Tumor; Dacarbazine; Gene Expression Regulation, Neoplastic; Gene Silencing; Glioblastoma; Humans; MicroRNAs; O(6)-Methylguanine-DNA Methyltransferase; Polyadenylation; Promoter Regions, Genetic; Temozolomide | 2013 |
Anti-tumour efficacy on glioma models of PHA-848125, a multi-kinase inhibitor able to cross the blood-brain barrier.
Topics: Animals; Antineoplastic Agents; Blood-Brain Barrier; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Combined Modality Therapy; Dacarbazine; Drug Synergism; Glioma; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Protein Kinase Inhibitors; Pyrazoles; Quinazolines; Rats; Rats, Sprague-Dawley; Signal Transduction; Temozolomide; Xenograft Model Antitumor Assays | 2013 |
Predictive significance of mean apparent diffusion coefficient value for responsiveness of temozolomide-refractory malignant glioma to bevacizumab: preliminary report.
Topics: Adult; Aged; Antibodies, Monoclonal, Humanized; Bevacizumab; Brain Neoplasms; Dacarbazine; Disease-Free Survival; Female; Glioma; Humans; Karnofsky Performance Status; Male; Middle Aged; Neoplasm Recurrence, Local; Temozolomide; Treatment Outcome | 2014 |
The value of temozolomide in combination with radiotherapy during standard treatment for newly diagnosed glioblastoma.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemoradiotherapy; Chemotherapy, Adjuvant; Clinical Trials, Phase III as Topic; Dacarbazine; Disease Progression; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Female; Follow-Up Studies; Glioblastoma; Humans; Male; Middle Aged; Multicenter Studies as Topic; Neoplasm Recurrence, Local; Neoplasm Staging; Prognosis; Promoter Regions, Genetic; Prospective Studies; Randomized Controlled Trials as Topic; Survival Rate; Temozolomide; Tumor Suppressor Proteins | 2013 |
Patterns of relapse in glioblastoma multiforme following concomitant chemoradiotherapy with temozolomide.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemoradiotherapy; Dacarbazine; Disease-Free Survival; Female; Glioblastoma; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Radiotherapy, Conformal; Retrospective Studies; Temozolomide; Treatment Failure; Young Adult | 2013 |
Breast metastasis of anaplastic oligodendroglioma: a case report.
Topics: Antineoplastic Agents, Alkylating; Aphasia; Brain Neoplasms; Breast Neoplasms, Male; Chemoradiotherapy, Adjuvant; Dacarbazine; Disease Progression; Fatal Outcome; Humans; Magnetic Resonance Imaging; Male; Mammography; Middle Aged; Neoplasm Recurrence, Local; Oligodendroglioma; Temozolomide | 2012 |
Hypernatremia-associated myelinolysis following the management of sepsis in a patient with glioblastoma treated with radiotherapy and temozolomide.
Topics: Antineoplastic Agents; Brain Diseases; Brain Neoplasms; Carcinoma; Carcinoma, Papillary; Dacarbazine; Diabetes Mellitus; Fatal Outcome; Glioblastoma; Humans; Hypernatremia; Hypertension; Liver Diseases; Male; Middle Aged; Neoplasms, Second Primary; Radiotherapy, Conformal; Sepsis; Temozolomide; Thyroid Cancer, Papillary; Thyroid Neoplasms | 2013 |
Using susceptibility-weighted imaging to determine response to combined anti-angiogenic, cytotoxic, and radiation therapy in patients with glioblastoma multiforme.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Chemoradiotherapy; Dacarbazine; Female; Follow-Up Studies; Glioblastoma; Humans; Image Processing, Computer-Assisted; Indoles; Magnetic Resonance Imaging; Male; Middle Aged; Neoplasm Staging; Prognosis; Survival Rate; Temozolomide | 2013 |
Temozolomide as second-line chemotherapy for relapsed gliomas.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Female; Glioma; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Retrospective Studies; Temozolomide; Treatment Outcome | 2002 |
Multifaceted resistance of gliomas to temozolomide.
Topics: Alleles; Animals; Antineoplastic Agents, Alkylating; Apoptosis; Base Pair Mismatch; Blotting, Western; Brain Neoplasms; Cell Cycle; Cell Nucleus; Cytosol; Dacarbazine; DNA Damage; DNA Repair; Drug Resistance, Neoplasm; Glioma; Humans; Immunohistochemistry; In Situ Nick-End Labeling; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Reverse Transcriptase Polymerase Chain Reaction; Sequence Analysis, DNA; Temozolomide; Thioguanine; Time Factors; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2002 |
Relation between Irofulven (MGI-114) systemic exposure and tumor response in human solid tumor xenografts.
Topics: Animals; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Child; Chromatography, High Pressure Liquid; Cyclophosphamide; Dacarbazine; Dactinomycin; Disease-Free Survival; Doxorubicin; Female; Glioblastoma; Glioma; Humans; Medulloblastoma; Mice; Mice, Inbred CBA; Mice, Inbred ICR; Mice, SCID; Neoplasms; Neuroblastoma; Neuroectodermal Tumors, Primitive; Radiation Chimera; Random Allocation; Rhabdoid Tumor; Rhabdomyosarcoma, Embryonal; Sesquiterpenes; Tumor Cells, Cultured; Vincristine; Xenograft Model Antitumor Assays | 2002 |
The apurinic/apyrimidinic endonuclease activity of Ape1/Ref-1 contributes to human glioma cell resistance to alkylating agents and is elevated by oxidative stress.
Topics: Antineoplastic Agents, Alkylating; Apurinic Acid; Brain Neoplasms; Carbon-Oxygen Lyases; Carmustine; Dacarbazine; DNA Adducts; DNA Damage; DNA-(Apurinic or Apyrimidinic Site) Lyase; DNA, Neoplasm; Drug Resistance, Neoplasm; Enzyme Induction; Glioblastoma; Humans; Hypochlorous Acid; Methyl Methanesulfonate; Neoplasm Proteins; O(6)-Methylguanine-DNA Methyltransferase; Oxidative Stress; Reactive Oxygen Species; Temozolomide; Tumor Cells, Cultured | 2002 |
Poly(ADP-ribose) polymerase inhibitor increases growth inhibition and reduces G(2)/M cell accumulation induced by temozolomide in malignant glioma cells.
Topics: Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Benzamides; Brain Neoplasms; cdc25 Phosphatases; Cell Cycle Proteins; Checkpoint Kinase 1; Dacarbazine; DNA Repair; Down-Regulation; Drug Interactions; Drug Resistance, Neoplasm; Drug Therapy, Combination; Enzyme Inhibitors; G2 Phase; Glioblastoma; Glioma; Humans; Mitosis; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Protein Kinases; Proteins; Temozolomide; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Up-Regulation | 2002 |
Case report: a patient with primary CNS lymphoma treated with temozolomide to complete response.
Topics: Administration, Oral; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Female; Humans; Lymphoma, B-Cell; Magnetic Resonance Imaging; Radiography; Temozolomide | 2002 |
[Temozolomide as therapeutic option for patients with metastatic melanoma and poor prognosis].
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Female; Humans; Lymphatic Metastasis; Male; Melanoma; Middle Aged; Neoplasm Metastasis; Prognosis; Retrospective Studies; Skin Neoplasms; Temozolomide; Time Factors | 2002 |
Hemorrhagic cystitis as an unexpected adverse reaction to temozolomide: case report.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Breast Neoplasms; Cystitis; Dacarbazine; Female; Hemorrhage; Humans; Middle Aged; Temozolomide | 2002 |
[Treatment of anaplastic astrocytomas and glioblastomas in children by the use of temozolomide (TMZ)].
Topics: Adolescent; Adult; Age Factors; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Brain Stem Neoplasms; Cerebellar Neoplasms; Child; Child, Preschool; Dacarbazine; Data Interpretation, Statistical; Female; Glioblastoma; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Temozolomide; Time Factors | 2002 |
[Complete response of cerebral metastasic melanoma after a combined treatment of radiotherapy and temozolomide].
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Humans; Male; Melanoma; Middle Aged; Remission Induction; Skin Neoplasms; Temozolomide; Temporal Lobe | 2002 |
Use of temozolomide with other cytotoxic chemotherapy in the treatment of patients with recurrent brain metastases from lung cancer.
Topics: Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Small Cell; Combined Modality Therapy; Dacarbazine; Etoposide; Female; Humans; Lung Neoplasms; Middle Aged; Prognosis; Temozolomide; Treatment Outcome | 2003 |
HIV-related Hodgkin's disease with central nervous system involvement and association with Epstein-Barr virus.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Antiretroviral Therapy, Highly Active; Biopsy; Bleomycin; Brain Neoplasms; Dacarbazine; Doxorubicin; Fatal Outcome; Herpesvirus 4, Human; HIV Infections; Hodgkin Disease; Homosexuality; Humans; Immunohistochemistry; Magnetic Resonance Imaging; Male; Neoplasm Staging; Reed-Sternberg Cells; Tomography, Emission-Computed, Single-Photon; Tomography, X-Ray Computed; Vinblastine | 2003 |
Interobserver variability in the radiological assessment of response to chemotherapy in glioma.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Carboplatin; Dacarbazine; Ependymoma; Female; Glioblastoma; Glioma; Humans; Image Enhancement; Lomustine; Magnetic Resonance Imaging; Male; Middle Aged; Neoplasm Recurrence, Local; Observer Variation; Oligodendroglioma; Paclitaxel; Procarbazine; Sensitivity and Specificity; Temozolomide; Tomography, X-Ray Computed; Treatment Outcome; Vincristine | 2003 |
Impact of chromosome 1p status in response of oligodendroglioma to temozolomide: preliminary results.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chromosomes, Human, Pair 1; Dacarbazine; Data Interpretation, Statistical; Female; Humans; Loss of Heterozygosity; Male; Middle Aged; Oligodendroglioma; Retrospective Studies; Temozolomide; Treatment Outcome | 2003 |
Combined effects of temozolomide and the ribonucleotide reductase inhibitors didox and trimidox in malignant brain tumor cells.
Topics: Antineoplastic Agents, Alkylating; Benzamidines; Brain Neoplasms; Dacarbazine; Drug Synergism; Enzyme Inhibitors; Glioma; Humans; Hydroxamic Acids; Ribonucleotide Reductases; Temozolomide; Tumor Cells, Cultured | 2003 |
Temozolomide as an alternative to irradiation for elderly patients with newly diagnosed malignant gliomas.
Topics: Administration, Oral; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cohort Studies; Dacarbazine; Female; Glioma; Humans; Male; Retrospective Studies; Survival Rate; Temozolomide | 2003 |
Metabolic activation of temozolomide measured in vivo using positron emission tomography.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Biotransformation; Brain Neoplasms; Carbon Dioxide; Carbon Radioisotopes; Dacarbazine; Glioma; Humans; Male; Middle Aged; Temozolomide; Tomography, Emission-Computed | 2003 |
Formation of DNA adducts and induction of lacI mutations in Big Blue Rat-2 cells treated with temozolomide: implications for the treatment of low-grade adult and pediatric brain tumors.
Topics: Alkylation; Animals; Antineoplastic Agents, Alkylating; Biomarkers, Tumor; Brain Neoplasms; Dacarbazine; Disease Models, Animal; DNA Adducts; DNA Mutational Analysis; Dose-Response Relationship, Drug; Gene Expression Regulation; Gene Frequency; O(6)-Methylguanine-DNA Methyltransferase; Point Mutation; Rats; Severity of Illness Index; Statistics as Topic; Temozolomide; Time Factors; Treatment Outcome; Tumor Cells, Cultured | 2003 |
Survival improvement in patients with glioblastoma multiforme during the last 20 years in a single tertiary-care center.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Clinical Trials as Topic; Cobalt Radioisotopes; Combined Modality Therapy; Dacarbazine; Female; Glioblastoma; Humans; Lomustine; Magnetic Resonance Imaging; Male; Middle Aged; Nitrosourea Compounds; Organophosphorus Compounds; Radiotherapy Dosage; Survival Analysis; Time Factors; Tomography, X-Ray Computed | 2003 |
Temozolomide: too early for definitive conclusions.
Topics: Adult; Age Factors; Antineoplastic Agents, Alkylating; Brain Neoplasms; Child; Clinical Trials as Topic; Cognition Disorders; Dacarbazine; Disease Progression; Glioma; Humans; Radiation Injuries; Reproducibility of Results; Temozolomide | 2003 |
Response of recurrent anaplastic ependymoma to a combination of tamoxifen and isotretinoin.
Topics: Adrenal Cortex Hormones; Adult; Antineoplastic Combined Chemotherapy Protocols; Brain; Brain Neoplasms; Carboplatin; Carmustine; Dacarbazine; Disease Progression; Dose Fractionation, Radiation; Ependymoma; Gadolinium; Headache; Humans; Isotretinoin; Magnetic Resonance Imaging; Male; Neoplasm Recurrence, Local; Remission Induction; Tamoxifen; Temozolomide; Tomography, X-Ray Computed; Treatment Outcome | 2003 |
Treatment of glioblastoma multiforme in the elderly in functionally non-critical areas. Clinical remarks on 22 patients.
Topics: Aged; Aged, 80 and over; Brain Neoplasms; Dacarbazine; Female; Glioblastoma; Humans; Male; Neoplasm Recurrence, Local; Neoplasm, Residual; Survival Rate; Temozolomide | 2003 |
Response to low dose temozolomide in radiation induced gliomatosis cerebri.
Topics: Adolescent; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Female; Humans; Leukemia, B-Cell; Magnetic Resonance Imaging; Neoplasms, Neuroepithelial; Neoplasms, Radiation-Induced; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Temozolomide; Treatment Outcome | 2003 |
Systemic administration of GPI 15427, a novel poly(ADP-ribose) polymerase-1 inhibitor, increases the antitumor activity of temozolomide against intracranial melanoma, glioma, lymphoma.
Topics: Animals; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Drug Synergism; Enzyme Inhibitors; Glioblastoma; Humans; Lymphoma; Male; Melanoma, Experimental; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred DBA; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Survival Rate; Temozolomide; Transplantation, Heterologous; Tumor Cells, Cultured | 2003 |
Promises and controversies in the management of low-grade glioma.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Clinical Trials, Phase II as Topic; Combined Modality Therapy; Dacarbazine; Disease Progression; Disease-Free Survival; Glioma; Humans; Neoplasm Staging; Prognosis; Temozolomide | 2003 |
Gliomatosis cerebri: clinical, neurochemical and neuroradiological response to temozolomide administration.
Topics: Antineoplastic Agents, Alkylating; Brain; Brain Neoplasms; Dacarbazine; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Neoplasms, Neuroepithelial; Temozolomide; Treatment Outcome | 2003 |
[Temozolomide in patients with melanoma brain metastases treated with whole brain irradiation].
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Female; Humans; Male; Melanoma; Middle Aged; Retrospective Studies; Survival Rate; Temozolomide | 2004 |
Irinotecan-induced interstitial pneumonia.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Camptothecin; Dacarbazine; Diagnosis, Differential; Frontal Lobe; Glioblastoma; Humans; Irinotecan; Lung Diseases, Interstitial; Male; Radiography; Temozolomide | 2004 |
Complete response of multiple melanoma brain metastases after treatment with temozolomide.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Female; Humans; Magnetic Resonance Imaging; Melanoma; Middle Aged; Neoplasms, Multiple Primary; Remission Induction; Skin Neoplasms; Temozolomide; Treatment Outcome | 2004 |
Long-term outcome of oligodendrogliomas.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Biopsy; Brain Neoplasms; Cisplatin; Combined Modality Therapy; Cranial Irradiation; Craniotomy; Dacarbazine; Epilepsies, Partial; Etoposide; Female; Follow-Up Studies; Humans; Life Tables; Lomustine; Magnetic Resonance Imaging; Male; Middle Aged; Neoadjuvant Therapy; Nitrosourea Compounds; Oligodendroglioma; Organophosphorus Compounds; Procarbazine; Prognosis; Proportional Hazards Models; Radionuclide Imaging; Radiopharmaceuticals; Survival Analysis; Technetium Tc 99m Sestamibi; Temozolomide; Treatment Outcome; Vincristine | 2004 |
Plasma and cerebrospinal fluid population pharmacokinetics of temozolomide in malignant glioma patients.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Area Under Curve; Brain Neoplasms; Chromatography, High Pressure Liquid; Clinical Trials as Topic; Dacarbazine; Disease-Free Survival; Female; Glioma; Humans; Kinetics; Male; Middle Aged; Temozolomide; Treatment Outcome | 2004 |
Cooperative function of Chk1 and p38 pathways in activating G2 arrest following exposure to temozolomide.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Checkpoint Kinase 1; Dacarbazine; Drug Resistance, Neoplasm; G2 Phase; Glioma; Humans; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinases; Temozolomide; Tumor Cells, Cultured | 2004 |
Quality assurance of the EORTC 26981/22981; NCIC CE3 intergroup trial on radiotherapy with or without temozolomide for newly-diagnosed glioblastoma multiforme: the individual case review.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Clinical Protocols; Clinical Trials, Phase III as Topic; Combined Modality Therapy; Dacarbazine; Glioblastoma; Guideline Adherence; Humans; Multicenter Studies as Topic; Practice Guidelines as Topic; Quality Assurance, Health Care; Radiotherapy Dosage; Randomized Controlled Trials as Topic; Temozolomide | 2004 |
Gliomatosis cerebri: better definition, better treatment.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Astrocytes; Astrocytoma; Brain; Brain Neoplasms; Cell Cycle Proteins; Dacarbazine; Disease Progression; Female; Humans; Lomustine; Magnetic Resonance Imaging; Male; Middle Aged; Neoplasm Invasiveness; Neoplasm Proteins; Neoplasms, Neuroepithelial; Nerve Tissue Proteins; Procarbazine; Temozolomide; Vincristine | 2004 |
Temozolomide as initial treatment for adults with low-grade oligodendrogliomas or oligoastrocytomas and correlation with chromosome 1p deletions.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Chromosome Deletion; Chromosomes, Human, Pair 1; Dacarbazine; Female; Humans; Loss of Heterozygosity; Magnetic Resonance Imaging; Male; Middle Aged; Oligodendroglioma; Temozolomide | 2004 |
CpG island hypermethylation of the DNA repair enzyme methyltransferase predicts response to temozolomide in primary gliomas.
Topics: Adult; Aged; Alkylating Agents; Brain Neoplasms; Carmustine; CpG Islands; Dacarbazine; DNA; DNA Methylation; DNA Repair; Female; Glioma; Humans; Male; Middle Aged; O(6)-Methylguanine-DNA Methyltransferase; Polymerase Chain Reaction; Promoter Regions, Genetic; Temozolomide; Treatment Outcome | 2004 |
Effect of association of temozolomide with other chemotherapic agents on cell growth inhibition in glioma cell lines.
Topics: Antineoplastic Agents; Antineoplastic Agents, Alkylating; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cell Proliferation; Cisplatin; Dacarbazine; Doxorubicin; Drug Interactions; Glioma; Humans; Temozolomide; Topotecan; Tumor Cells, Cultured | 2004 |
Transcriptional targeting of adenovirally delivered tumor necrosis factor alpha by temozolomide in experimental glioblastoma.
Topics: Adenoviruses, Human; Animals; Antineoplastic Agents, Alkylating; Apoptosis; Brain Neoplasms; Cell Line, Tumor; Cell Survival; Combined Modality Therapy; Dacarbazine; Female; Glioblastoma; Humans; Mice; Mice, Nude; Temozolomide; Transcription, Genetic; Tumor Necrosis Factor-alpha; Xenograft Model Antitumor Assays | 2004 |
Can we afford to add chemotherapy to radiotherapy for glioblastoma multiforme? Cost-identification analysis of concomitant and adjuvant treatment with temozolomide until patient death.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Combined Modality Therapy; Cost-Benefit Analysis; Dacarbazine; Europe; Female; Glioblastoma; Health Care Costs; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; O(6)-Methylguanine-DNA Methyltransferase; Temozolomide | 2004 |
Convection-enhanced delivery of tumor necrosis factor-related apoptosis-inducing ligand with systemic administration of temozolomide prolongs survival in an intracranial glioblastoma xenograft model.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Apoptosis Regulatory Proteins; Brain Neoplasms; Cell Line, Tumor; Convection; Dacarbazine; Drug Delivery Systems; Drug Synergism; Glioblastoma; Humans; Male; Membrane Glycoproteins; Rats; Rats, Nude; Recombinant Proteins; Temozolomide; TNF-Related Apoptosis-Inducing Ligand; Tumor Necrosis Factor-alpha; Xenograft Model Antitumor Assays | 2004 |
Temozolomide for the treatment of recurrent supratentorial glioma: results of a compassionate use program in Belgium.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Belgium; Brain Neoplasms; Dacarbazine; Female; Glioblastoma; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Retrospective Studies; Supratentorial Neoplasms; Survival Rate; Temozolomide; Treatment Outcome | 2004 |
Intracranial metastatic esthesioneuroblastoma responsive to temozolomide.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Esthesioneuroblastoma, Olfactory; Female; Humans; Middle Aged; Nasal Cavity; Nose Neoplasms; Quality of Life; Temozolomide | 2004 |
The piperidine nitroxide Tempol potentiates the cytotoxic effects of temozolomide in human glioblastoma cells.
Topics: Antineoplastic Agents, Alkylating; Antioxidants; Apoptosis; Brain Neoplasms; Cell Cycle; Cyclic N-Oxides; Dacarbazine; Drug Interactions; Glioblastoma; Humans; Spin Labels; Temozolomide; Tumor Cells, Cultured | 2004 |
Breast metastases from cutaneous malignant melanoma.
Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Breast Neoplasms; Combined Modality Therapy; Cyclophosphamide; Dacarbazine; Female; Humans; Melanoma; Middle Aged; Skin Neoplasms; Vincristine | 2004 |
Continuous low-dose chemotherapy plus inhibition of cyclooxygenase-2 as an antiangiogenic therapy of glioblastoma multiforme.
Topics: Adult; Angiogenesis Inhibitors; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dacarbazine; Disease-Free Survival; Drug Administration Schedule; Female; Glioblastoma; Humans; Immunohistochemistry; Isoenzymes; Lactones; Male; Membrane Proteins; Middle Aged; Neovascularization, Pathologic; Prostaglandin-Endoperoxide Synthases; Sulfones; Survival Analysis; Temozolomide | 2005 |
Pharmacokinetic model-predicted anticancer drug concentrations in human tumors.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carboplatin; Computer Simulation; Cyclohexanes; Dacarbazine; Female; Humans; Male; Models, Biological; O-(Chloroacetylcarbamoyl)fumagillol; Ovarian Neoplasms; Predictive Value of Tests; Rats; Rats, Inbred F344; Rats, Nude; Sesquiterpenes; Temozolomide; Topotecan; Transplantation, Heterologous; Vascular Endothelial Growth Factor A | 2004 |
Hierarchical models for tumor xenograft experiments in drug development.
Topics: Algorithms; Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Bayes Theorem; Brain Neoplasms; Camptothecin; Dacarbazine; Humans; Likelihood Functions; Longitudinal Studies; Markov Chains; Mice; Models, Statistical; Monte Carlo Method; Neoplasm Transplantation; Neuroblastoma; Predictive Value of Tests; Temozolomide; Transplantation, Heterologous | 2004 |
Making inferences about projected completors in longitudinal studies.
Topics: Algorithms; Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Bayes Theorem; Brain Neoplasms; Camptothecin; Dacarbazine; Humans; Likelihood Functions; Longitudinal Studies; Markov Chains; Mice; Models, Statistical; Monte Carlo Method; Neoplasm Transplantation; Neuroblastoma; Predictive Value of Tests; Temozolomide; Transplantation, Heterologous | 2004 |
Dexamethasone protected human glioblastoma U87MG cells from temozolomide induced apoptosis by maintaining Bax:Bcl-2 ratio and preventing proteolytic activities.
Topics: Antineoplastic Agents, Alkylating; Antineoplastic Agents, Hormonal; Apoptosis; bcl-2-Associated X Protein; Brain Neoplasms; Calcium; Calpain; Caspase 3; Caspases; Cell Line, Tumor; Cell Survival; Dacarbazine; Dexamethasone; Glioblastoma; Humans; Proto-Oncogene Proteins c-bcl-2; Spectrin; Temozolomide | 2004 |
Innovative therapy for patients with brain metastases: oral treatments.
Topics: Administration, Oral; Brain Neoplasms; Capecitabine; Combined Modality Therapy; Dacarbazine; Deoxycytidine; Fluorouracil; Gefitinib; Humans; Quinazolines; Temozolomide | 2004 |
Low-grade primary meningeal lymphoma: case report and review of the literature.
Topics: Aged; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Glioblastoma; Hemangioma; Humans; Magnetic Resonance Imaging; Male; Neoplasms, Radiation-Induced; Paresis; Seizures; Temozolomide; Tinea Capitis | 2005 |
Neoadjuvant temozolomide followed by complete resection of a 1p- and 19q-deleted anaplastic oligoastrocytoma: case study.
Topics: Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Chromosome Deletion; Chromosomes, Human, Pair 1; Chromosomes, Human, Pair 19; Combined Modality Therapy; Dacarbazine; Female; Humans; In Situ Hybridization, Fluorescence; Magnetic Resonance Imaging; Neoadjuvant Therapy; Temozolomide | 2005 |
Successful treatment of a chemoresistant tumor with temozolomide in an adult patient: report of a recurrent intracranial mesenchymal chondrosarcoma.
Topics: Adult; Antineoplastic Agents, Alkylating; Bone Neoplasms; Brain Neoplasms; Chondrosarcoma, Mesenchymal; Dacarbazine; Drug Resistance, Neoplasm; Humans; Male; Neoplasm Recurrence, Local; Temozolomide; Treatment Outcome | 2005 |
Salvage therapy for primary CNS lymphoma with a combination of rituximab and temozolomide.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Brain; Brain Neoplasms; Clinical Trials, Phase I as Topic; Dacarbazine; Dose-Response Relationship, Drug; Drug Synergism; Hematologic Diseases; Humans; Kidney; Lymphoma; Maximum Tolerated Dose; Meningeal Neoplasms; Neoplasm Recurrence, Local; Rituximab; Temozolomide; Treatment Outcome | 2005 |
Efficacy and toxicity of postoperative temozolomide radiochemotherapy in malignant glioma.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Glioma; Humans; Middle Aged; Neoplasm Recurrence, Local; Retrospective Studies; Survival Analysis; Temozolomide | 2005 |
MGMT gene silencing and benefit from temozolomide in glioblastoma.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemotherapy, Adjuvant; Dacarbazine; Disease-Free Survival; DNA Methylation; Gene Silencing; Glioblastoma; Humans; O(6)-Methylguanine-DNA Methyltransferase; Polymerase Chain Reaction; Promoter Regions, Genetic; Randomized Controlled Trials as Topic; Survival Analysis; Temozolomide | 2005 |
Chemotherapy for brain tumors--a new beginning.
Topics: Adult; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cerebellar Neoplasms; Chemotherapy, Adjuvant; Child, Preschool; Dacarbazine; Gene Silencing; Glioblastoma; Humans; Medulloblastoma; O(6)-Methylguanine-DNA Methyltransferase; Survival Analysis; Temozolomide | 2005 |
Cerebral metastases of malignant melanoma: contemporary treatment modalities and survival outcome.
Topics: Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Disease Progression; Female; Humans; Male; Melanoma; Middle Aged; Prognosis; Radiotherapy, Adjuvant; Retrospective Studies; Skin Neoplasms; Survival Analysis; Temozolomide; Treatment Outcome | 2005 |
Pharmaceutical-mediated inactivation of p53 sensitizes U87MG glioma cells to BCNU and temozolomide.
Topics: Antineoplastic Agents, Alkylating; Benzothiazoles; Brain Neoplasms; Carmustine; Dacarbazine; DNA Damage; Drug Interactions; Glioma; Humans; Temozolomide; Thiazoles; Toluene; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2005 |
Temozolomide in combination with BCNU before and after radiotherapy in patients with inoperable newly diagnosed glioblastoma multiforme.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carmustine; Combined Modality Therapy; Dacarbazine; Disease Progression; Disease-Free Survival; Female; Glioblastoma; Humans; Male; Middle Aged; Survival Analysis; Temozolomide | 2005 |
Treatment of brain metastases from melanoma.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Clinical Trials as Topic; Dacarbazine; Endpoint Determination; Humans; Reproducibility of Results; Temozolomide; Treatment Outcome | 2005 |
Combined cimetidine and temozolomide, compared with temozolomide alone: significant increases in survival in nude mice bearing U373 human glioblastoma multiforme orthotopic xenografts.
Topics: Adjuvants, Immunologic; Animals; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cimetidine; Dacarbazine; Female; Glioblastoma; Mice; Mice, Nude; Temozolomide; Transplantation, Heterologous | 2005 |
Cytotoxic T cell targeting of TRP-2 sensitizes human malignant glioma to chemotherapy.
Topics: Antigens, Neoplasm; Antineoplastic Agents; Brain Neoplasms; Carboplatin; Combined Modality Therapy; Dacarbazine; DNA Damage; Drug Interactions; Drug Resistance, Neoplasm; Glioma; Humans; Immunotherapy, Active; Intramolecular Oxidoreductases; T-Lymphocytes, Cytotoxic; Temozolomide; Transfection; Treatment Outcome; Tumor Cells, Cultured | 2005 |
Treatment of brain tumors.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemotherapy, Adjuvant; Dacarbazine; Gene Silencing; Glioblastoma; Humans; O(6)-Methylguanine-DNA Methyltransferase; Salvage Therapy; Survival Analysis; Temozolomide | 2005 |
Treatment of brain tumors.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Carmustine; Chemotherapy, Adjuvant; Dacarbazine; Glioblastoma; Humans; O(6)-Methylguanine-DNA Methyltransferase; Survival Analysis; Temozolomide | 2005 |
Use of magnetic resonance imaging to assess blood-brain/blood-glioma barrier opening during conformal radiotherapy.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Blood-Brain Barrier; Brain Neoplasms; Carboxymethylcellulose Sodium; Combined Modality Therapy; Contrast Media; Dacarbazine; Dose Fractionation, Radiation; Female; Gadolinium DTPA; Glioma; Humans; Interferon Inducers; Linear Models; Magnetic Resonance Imaging; Male; Middle Aged; Poly I-C; Polylysine; Radiotherapy Dosage; Radiotherapy, Conformal; Survival Analysis; Temozolomide; Treatment Outcome | 2005 |
Maintenance of fertility following treatment with temozolomide for a high grade astrocytoma.
Topics: Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Dacarbazine; Fertility; Humans; Infertility, Male; Male; Temozolomide; Treatment Outcome | 2005 |
[Temozolomide in patients with a glioblastoma multiforme: new developments].
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemotherapy, Adjuvant; Dacarbazine; Glioblastoma; Humans; Neoplasm Recurrence, Local; Survival Rate; Temozolomide; Treatment Outcome | 2005 |
[Favourable result for temozolomide in recurrent high-grade glioma].
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Disease Progression; Female; Glioma; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Retrospective Studies; Temozolomide; Treatment Outcome | 2005 |
Modeling antitumor activity in xenograft tumor treatment.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Camptothecin; Computer Simulation; Dacarbazine; Dose-Response Relationship, Drug; Drug Therapy, Computer-Assisted; Irinotecan; Mice; Models, Biological; Models, Statistical; Temozolomide; Treatment Outcome; Xenograft Model Antitumor Assays | 2005 |
Economic evaluation of temozolomide in the treatment of recurrent glioblastoma multiforme.
Topics: Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cost-Benefit Analysis; Dacarbazine; Finland; Glioblastoma; Humans; Recurrence; Temozolomide | 2005 |
Perifosine inhibits multiple signaling pathways in glial progenitors and cooperates with temozolomide to arrest cell proliferation in gliomas in vivo.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; CDC2-CDC28 Kinases; Cell Growth Processes; Cell Line, Tumor; Cyclin-Dependent Kinase 2; Dacarbazine; Dose-Response Relationship, Drug; Drug Synergism; G1 Phase; G2 Phase; Glioma; Humans; Mice; Mice, Transgenic; Phosphorylcholine; Platelet-Derived Growth Factor; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Signal Transduction; Temozolomide; TOR Serine-Threonine Kinases; Xenograft Model Antitumor Assays | 2005 |
Complete remission of brain metastases in three patients with stage IV melanoma treated with BOLD and G-CSF.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Brain Neoplasms; Dacarbazine; Disease-Free Survival; Female; Granulocyte Colony-Stimulating Factor; Humans; Lomustine; Male; Melanoma; Middle Aged; Neoplasm Staging; Remission Induction; Skin Neoplasms; Treatment Outcome; Vincristine | 2005 |
Current therapies for glioblastoma.
Topics: Antineoplastic Agents; Brain Neoplasms; Clinical Trials as Topic; Cranial Irradiation; Craniotomy; Dacarbazine; Drug Delivery Systems; Drug Design; Genetic Therapy; Glioblastoma; Humans; Neoplasm Proteins; Patient Acceptance of Health Care; Quality of Life; Research Design; RNA, Antisense; Survival Rate; Temozolomide; Vascular Endothelial Growth Factor A | 2004 |
Simulating chemotherapeutic schemes in the individualized treatment context: the paradigm of glioblastoma multiforme treated by temozolomide in vivo.
Topics: Antineoplastic Agents, Alkylating; Apoptosis; Brain Neoplasms; Cell Cycle; Cell Division; Computer Graphics; Computer Simulation; Dacarbazine; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Computer-Assisted; Glioblastoma; Humans; Image Processing, Computer-Assisted; Imaging, Three-Dimensional; Magnetic Resonance Imaging; Necrosis; Oligonucleotide Array Sequence Analysis; Software; Temozolomide | 2006 |
Patients with high-grade gliomas harboring deletions of chromosomes 9p and 10q benefit from temozolomide treatment.
Topics: Adult; Age Factors; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chromosome Deletion; Chromosomes; Chromosomes, Human, Pair 10; Chromosomes, Human, Pair 9; Cytogenetics; Dacarbazine; Female; Gene Deletion; Genetic Markers; Glioblastoma; Glioma; Humans; Loss of Heterozygosity; Male; Microsatellite Repeats; Middle Aged; Models, Genetic; Multivariate Analysis; Nucleic Acid Hybridization; Paraffin; Prognosis; Proportional Hazards Models; Sex Factors; Temozolomide; Time Factors; Treatment Outcome | 2005 |
Does addition of temozolomide to whole brain radiotherapy improve outcome in patients with brain metastases?
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Clinical Trials as Topic; Combined Modality Therapy; Cranial Irradiation; Dacarbazine; Humans; Temozolomide | 2005 |
Salvage temozolomide for prior temozolomide responders.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Dacarbazine; Female; Glioblastoma; Humans; Male; Middle Aged; Oligodendroglioma; Recurrence; Retrospective Studies; Salvage Therapy; Survival Analysis; Temozolomide | 2005 |
Efficiency, quality and bureaucracy: not always in the same bag!!
Topics: Antineoplastic Agents, Alkylating; Biomedical Research; Brain Neoplasms; Clinical Trials as Topic; Dacarbazine; Humans; Temozolomide; Treatment Outcome | 2005 |
10 questions about temozolomide and the treatment of brain tumors.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Humans; Temozolomide | 2005 |
Poly(ADP-ribose) glycohydrolase inhibitor as chemosensitiser of malignant melanoma for temozolomide.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Dacarbazine; Drug Interactions; Fluorenes; Glycoside Hydrolases; Melanoma; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Neoplasm Transplantation; Skin Neoplasms; Temozolomide | 2005 |
Higher dosing of temozolomide? Regression of an anaplastic oligoastrocytoma over more than three years.
Topics: Antineoplastic Agents, Alkylating; Astrocytoma; Bone Marrow; Brain Neoplasms; Dacarbazine; Drug Overdose; Humans; Leukopenia; Magnetic Resonance Imaging; Male; Middle Aged; Temozolomide; Thrombocytopenia | 2006 |
A congenital brain tumor associated with assisted in vitro fertilization. Case report.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Dacarbazine; Female; Fertilization in Vitro; Humans; Infant, Newborn; Magnetic Resonance Imaging; Male; Pregnancy; Temozolomide; Vincristine | 2005 |
Combination treatment with temozolomide and thalidomide inhibits tumor growth and angiogenesis in an orthotopic glioma model.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents, Alkylating; Apoptosis; Brain Neoplasms; Cell Proliferation; Dacarbazine; Gene Expression Profiling; Glioma; Humans; In Situ Nick-End Labeling; Neovascularization, Pathologic; Rats; Rats, Sprague-Dawley; Temozolomide; Thalidomide; Transplantation, Heterologous | 2006 |
Combination celecoxib and temozolomide in C6 rat glioma orthotopic model.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Celecoxib; Cyclooxygenase Inhibitors; Dacarbazine; Glioma; Immunohistochemistry; Platelet Endothelial Cell Adhesion Molecule-1; Proliferating Cell Nuclear Antigen; Pyrazoles; Rats; Rats, Sprague-Dawley; Sulfonamides; Temozolomide | 2006 |
Chemotherapy for glioblastoma multiforme (GBM).
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Glioblastoma; Humans; Temozolomide | 2006 |
Biochemotherapy with temozolomide, cisplatin, vinblastine, subcutaneous interleukin-2 and interferon-alpha in patients with metastatic melanoma.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cisplatin; Combined Modality Therapy; Dacarbazine; Disease-Free Survival; Female; Humans; Injections, Subcutaneous; Interferon alpha-2; Interferon-alpha; Interleukin-2; Male; Melanoma; Middle Aged; Recombinant Proteins; Skin Neoplasms; Survival Rate; Temozolomide; Treatment Outcome; Vinblastine | 2006 |
A case report of a recurrent intracranial ependymoma treated with temozolomide in remission 10 years after completing chemotherapy.
Topics: Adult; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Ependymoma; Female; Humans; Neoplasm Recurrence, Local; Temozolomide; Time Factors | 2006 |
Progressive low-grade oligodendrogliomas: response to temozolomide and correlation between genetic profile and O6-methylguanine DNA methyltransferase protein expression.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chromosomes, Human, Pair 1; Chromosomes, Human, Pair 19; Dacarbazine; Disease Progression; DNA Repair; Female; Humans; Immunohistochemistry; Loss of Heterozygosity; Male; Middle Aged; O(6)-Methylguanine-DNA Methyltransferase; Oligodendroglioma; Temozolomide | 2006 |
Antiangiogenic agent, thalidomide increases the antitumor effect of single high dose irradiation (gamma knife radiosurgery) in the rat orthotopic glioma model.
Topics: Angiogenesis Inhibitors; Animals; Apoptosis; Brain Neoplasms; Cell Proliferation; Combined Modality Therapy; Dacarbazine; Disease Models, Animal; Dose-Response Relationship, Radiation; Drug Synergism; Drug Therapy, Combination; Glioma; Male; Microcirculation; Radiosurgery; Rats; Rats, Sprague-Dawley; Temozolomide; Thalidomide | 2006 |
MGMT promoter methylation correlates with survival benefit and sensitivity to temozolomide in pediatric glioblastoma.
Topics: Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cell Line, Tumor; Child; Child, Preschool; Dacarbazine; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; DNA, Neoplasm; Drug Resistance, Neoplasm; Etoposide; Gene Silencing; Glioblastoma; Humans; Kaplan-Meier Estimate; Neoplasm Proteins; Retrospective Studies; Temozolomide; Treatment Outcome; Tumor Suppressor Proteins | 2007 |
A hypermutation phenotype and somatic MSH6 mutations in recurrent human malignant gliomas after alkylator chemotherapy.
Topics: Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; DNA-Binding Proteins; Female; Glioma; Humans; Male; Middle Aged; Mutation; Neoplasm Recurrence, Local; Protein Kinases; Temozolomide | 2006 |
Radical surgery after chemotherapy: a new therapeutic strategy to envision in grade II glioma.
Topics: Adult; Antineoplastic Agents, Alkylating; Brain Neoplasms; Combined Modality Therapy; Corpus Callosum; Dacarbazine; Frontal Lobe; Glioma; Humans; Magnetic Resonance Imaging; Male; Neurosurgical Procedures; Postoperative Care; Temozolomide | 2006 |
Complications of a temozolomide overdose: a case report.
Topics: Antineoplastic Agents, Alkylating; Bacterial Infections; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Glioblastoma; Humans; Male; Middle Aged; Pancytopenia; Temozolomide | 2006 |
Whole brain irradiation and temozolomide based chemotherapy in melanoma brain metastases.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cisplatin; Cohort Studies; Combined Modality Therapy; Cranial Irradiation; Dacarbazine; Drug Administration Schedule; Drug Evaluation; Female; Humans; Interferon alpha-2; Interferon-alpha; Interleukin-2; Life Tables; Male; Melanoma; Middle Aged; Patient Selection; Proportional Hazards Models; Recombinant Proteins; Retrospective Studies; Survival Analysis; Temozolomide; Treatment Outcome; Vinblastine | 2006 |
Enhancement of glioblastoma cell killing by combination treatment with temozolomide and tamoxifen or hypericin.
Topics: Animals; Anthracenes; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Brain Neoplasms; Cell Cycle Proteins; Cell Line, Tumor; Cell Survival; Dacarbazine; Disease Models, Animal; Down-Regulation; Drug Synergism; Glioblastoma; Growth Inhibitors; Humans; Male; Mice; Mice, Nude; Perylene; Tamoxifen; Temozolomide; Transplantation, Heterologous; Treatment Outcome | 2006 |
Listeria brain abscess, Pneumocystis pneumonia and Kaposi's sarcoma after temozolomide.
Topics: Antineoplastic Agents, Alkylating; Brain Abscess; Brain Neoplasms; Dacarbazine; Glioblastoma; Humans; Listeriosis; Male; Middle Aged; Neoadjuvant Therapy; Pneumocystis carinii; Pneumonia, Pneumocystis; Sarcoma, Kaposi; Temozolomide | 2006 |
Apoptosis in malignant glioma cells triggered by the temozolomide-induced DNA lesion O6-methylguanine.
Topics: Antineoplastic Agents, Alkylating; Apoptosis; Blotting, Western; Brain Neoplasms; Caspases; Cell Cycle; Cell Proliferation; Dacarbazine; DNA Breaks, Double-Stranded; DNA Damage; Fas Ligand Protein; Fas-Associated Death Domain Protein; Flow Cytometry; Glioma; Guanine; Humans; Methylnitronitrosoguanidine; O(6)-Methylguanine-DNA Methyltransferase; Proto-Oncogene Proteins c-bcl-2; RNA, Small Interfering; Temozolomide; Tumor Cells, Cultured; Tumor Stem Cell Assay; Tumor Suppressor Protein p53 | 2007 |
Irradiation and hypoxia promote homing of haematopoietic progenitor cells towards gliomas by TGF-beta-dependent HIF-1alpha-mediated induction of CXCL12.
Topics: Animals; Antineoplastic Agents, Alkylating; Brain; Brain Neoplasms; Cell Hypoxia; Cell Line, Tumor; Cell Movement; Chemokine CXCL12; Chemokines, CXC; Dacarbazine; Gamma Rays; Glioma; Hematopoietic Stem Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Immunohistochemistry; Mice; Mice, Nude; Neoplasm Proteins; Promoter Regions, Genetic; Signal Transduction; Temozolomide; Transcription, Genetic; Transforming Growth Factor beta | 2006 |
Early change in glucose metabolic rate measured using FDG-PET in patients with high-grade glioma predicts response to temozolomide but not temozolomide plus radiotherapy.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents, Alkylating; Brain; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Drug Administration Schedule; Female; Fluorodeoxyglucose F18; Glioma; Glucose; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Positron-Emission Tomography; Radiopharmaceuticals; Radiotherapy Dosage; Temozolomide; Treatment Outcome | 2006 |
Temozolomide treatment of refractory epilepsy in a patient with an oligodendroglioma.
Topics: Adult; Anticonvulsants; Antineoplastic Agents, Alkylating; Brain Neoplasms; Comorbidity; Dacarbazine; Drug Resistance; Epilepsy; Humans; Magnetic Resonance Imaging; Male; Oligodendroglioma; Temozolomide; Treatment Outcome | 2006 |
Is protracted low-dose temozolomide feasible in glioma patients?
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Central Nervous System Neoplasms; Combined Modality Therapy; Dacarbazine; Feasibility Studies; Glioma; Humans; Lymphopenia; Temozolomide | 2006 |
In vitro drug response and molecular markers associated with drug resistance in malignant gliomas.
Topics: ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biomarkers, Tumor; Brain Neoplasms; Camptothecin; Carmustine; Cisplatin; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Glioma; Glutathione S-Transferase pi; Humans; Immunohistochemistry; Irinotecan; Paclitaxel; Structure-Activity Relationship; Tumor Suppressor Protein p53; Tumor Suppressor Proteins; Vincristine | 2006 |
1p/19q loss within oligodendroglioma is predictive for response to first line temozolomide but not to salvage treatment.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Chromosomes, Human, Pair 1; Chromosomes, Human, Pair 19; Clinical Trials, Phase II as Topic; Dacarbazine; Disease-Free Survival; Humans; In Situ Hybridization, Fluorescence; Multicenter Studies as Topic; Neoplasm Recurrence, Local; Oligodendroglioma; Prospective Studies; Salvage Therapy; Survival Analysis; Temozolomide; Treatment Outcome | 2006 |
Gliomatosis cerebri treatment in 11 elderly patients.
Topics: Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Disease Progression; Female; Humans; Lomustine; Magnetic Resonance Imaging; Male; Neoplasms, Neuroepithelial; Procarbazine; Survival Rate; Temozolomide | 2006 |
Re-evaluation of the cost effectiveness of temozolomide for malignant gliomas in British Columbia.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; British Columbia; Cost-Benefit Analysis; Dacarbazine; Disease-Free Survival; Female; Glioma; Humans; Lomustine; Male; Medical Records; Middle Aged; Neoplasm Recurrence, Local; Retrospective Studies; Survival Rate; Temozolomide; Treatment Outcome | 2006 |
A pilot study of primary temozolomide chemotherapy and deferred radiotherapy in elderly patients with glioblastoma.
Topics: Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Female; Glioblastoma; Humans; Male; Pilot Projects; Prognosis; Survival Rate; Temozolomide; Treatment Outcome | 2007 |
Development of luciferase tagged brain tumour models in mice for chemotherapy intervention studies.
Topics: Animals; Antineoplastic Agents, Alkylating; Blood-Brain Barrier; Brain Neoplasms; Cell Division; Cell Line, Tumor; Contrast Media; Dacarbazine; Drug Screening Assays, Antitumor; Female; Gadolinium DTPA; Immunohistochemistry; Luciferases; Luminescence; Magnetic Resonance Imaging; Male; Mice; Mice, Nude; Neoplasm Invasiveness; Temozolomide | 2006 |
Local intracerebral administration of O(6)-benzylguanine combined with systemic chemotherapy with temozolomide of a patient suffering from a recurrent glioblastoma.
Topics: Adult; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; Drug Resistance; Enzyme Inhibitors; Glioblastoma; Guanine; Humans; Infusions, Intralesional; Male; Neoplasm Recurrence, Local; Temozolomide; Treatment Outcome; Tumor Suppressor Proteins | 2007 |
Ganglioglioma occurring with glioblastoma multiforme: separate lesions or the same lesion?
Topics: Antineoplastic Agents, Alkylating; Astrocytes; Biomarkers, Tumor; Brain Neoplasms; Chemotherapy, Adjuvant; Combined Modality Therapy; Cranial Irradiation; Craniotomy; Dacarbazine; Dose Fractionation, Radiation; Female; Ganglioglioma; Glioblastoma; Humans; Magnetic Resonance Imaging; Middle Aged; Neoplasm Recurrence, Local; Neoplasms, Multiple Primary; Neuroglia; Neurologic Examination; Radiotherapy, Adjuvant; Reoperation; Temozolomide; Temporal Lobe | 2007 |
Spanish co-operative group of Medical Neuro-oncology (GENOM).
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Glioma; Humans; Medical Oncology; Neurology; Societies, Medical; Spain; Temozolomide; Treatment Outcome | 2006 |
Toxicity and efficacy of protracted low dose temozolomide for the treatment of low grade gliomas.
Topics: Adult; Aged; Antineoplastic Agents; Brain Neoplasms; Dacarbazine; Disease-Free Survival; Female; Glioma; Humans; Male; Middle Aged; Retrospective Studies; Temozolomide; Treatment Outcome | 2007 |
Potentiation of antiglioma effect with combined temozolomide and interferon-beta.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Brain Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Dacarbazine; Drug Synergism; Glioma; Humans; Interferon-beta; Mice; Mice, Nude; Neoplasm Transplantation; Neoplasms, Experimental; Temozolomide | 2006 |
The impact of thrombocytopenia from temozolomide and radiation in newly diagnosed adults with high-grade gliomas.
Topics: Adult; Aged; Anemia; Antineoplastic Agents, Alkylating; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Female; Glioma; Humans; Male; Middle Aged; Neutropenia; Retrospective Studies; Temozolomide; Thrombocytopenia; Treatment Outcome | 2007 |
Interindividual differences in anticancer drug cytotoxicity in primary human glioblastoma cells.
Topics: Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Culture Techniques; Dacarbazine; Drug Screening Assays, Antitumor; Female; Glial Fibrillary Acidic Protein; Glioblastoma; Humans; Immunohistochemistry; Male; Middle Aged; Temozolomide; Tumor Cells, Cultured | 2007 |
[Individualized chemotherapy based on drug sensitivity and resistance assay and MGMT protein expression for patients with malignant glioma--analysis of 42 cases].
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Child; Cisplatin; Dacarbazine; Drug Resistance, Neoplasm; Etoposide; Female; Gene Expression Regulation, Neoplastic; Glioblastoma; Glioma; Humans; Male; Middle Aged; Nausea; Neutropenia; O(6)-Methylguanine-DNA Methyltransferase; Remission Induction; Temozolomide; Young Adult | 2006 |
[Recent advances in the medical treatment of glioma-temozolomide].
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Drug Administration Schedule; Female; Glioblastoma; Glioma; Humans; Male; Radiotherapy Dosage; Survival Rate; Temozolomide | 2006 |
The Fanconi anemia (FA) pathway confers glioma resistance to DNA alkylating agents.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Carmustine; Cell Line, Tumor; Curcumin; Dacarbazine; DNA Modification Methylases; DNA Repair; DNA Repair Enzymes; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Enzyme Inhibitors; Fanconi Anemia Complementation Group D2 Protein; Fanconi Anemia Complementation Group F Protein; Fanconi Anemia Complementation Group Proteins; Glioma; Guanine; Humans; Protein Processing, Post-Translational; RNA Interference; RNA, Small Interfering; Temozolomide; Time Factors; Transfection; Tumor Suppressor Proteins; Ubiquitins | 2007 |
Salvage therapy for primary central nervous system lymphoma with (90)Y-Ibritumomab and Temozolomide.
Topics: Aged; Antibodies, Monoclonal; Antineoplastic Agents, Alkylating; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Disease-Free Survival; Female; Humans; Lymphoma; Magnetic Resonance Imaging; Middle Aged; Neoplasm Recurrence, Local; Radioimmunotherapy; Remission Induction; Salvage Therapy; Survival Rate; Temozolomide; Yttrium Radioisotopes | 2007 |
Local delivery of temozolomide by biodegradable polymers is superior to oral administration in a rodent glioma model.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Biocompatible Materials; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Delayed-Action Preparations; Drug Implants; Drug Screening Assays, Antitumor; Glioma; Maximum Tolerated Dose; Polymers; Rats; Rats, Inbred F344; Temozolomide | 2007 |
Preclinical pharmacokinetic and pharmacodynamic evaluation of metronomic and conventional temozolomide dosing regimens.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents, Alkylating; Blotting, Western; Brain Neoplasms; Cell Line; Cell Proliferation; Cell Survival; Dacarbazine; Drug Evaluation, Preclinical; Endothelial Cells; Glioma; Humans; Hydrogen-Ion Concentration; Hypoxia-Inducible Factor 1, alpha Subunit; Microdialysis; Neoplasm Transplantation; Rats; Rats, Nude; Reverse Transcriptase Polymerase Chain Reaction; Temozolomide | 2007 |
Prognosis factors of survival time in patients with glioblastoma multiforme: a multivariate analysis of 340 patients.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Brain Neoplasms; Chemotherapy, Adjuvant; Combined Modality Therapy; Cranial Irradiation; Dacarbazine; Disease-Free Survival; Female; Glioblastoma; Humans; Male; Middle Aged; Multivariate Analysis; Neoplasm, Residual; Prognosis; Radiotherapy, Adjuvant; Retrospective Studies; Temozolomide | 2007 |
Cross-priming by temozolomide enhances antitumor immunity of dendritic cell vaccination in murine brain tumor model.
Topics: Animals; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cross-Priming; Dacarbazine; Dendritic Cells; Disease Models, Animal; Female; Inhibitor of Apoptosis Proteins; Lymphocyte Activation; Mice; Mice, Inbred C57BL; Microtubule-Associated Proteins; Repressor Proteins; Survivin; Temozolomide; Transfection; Vaccination | 2007 |
[Cerebral tumours in the adult. A real increase].
Topics: Adult; Age Factors; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Clinical Trials, Phase III as Topic; Combined Modality Therapy; Dacarbazine; Glioma; Humans; Incidence; Lymphoma; Magnetic Resonance Imaging; Microarray Analysis; Neuronavigation; Patient Care Team; Prognosis; Prospective Studies; Quality of Life; Radiosurgery; Radiotherapy, Conformal; Temozolomide | 2006 |
O (4)-benzylfolic acid inactivates O (6)-alkylguanine-DNA alkyltransferase in brain tumor cell lines.
Topics: Antineoplastic Agents, Alkylating; Binding, Competitive; Brain Neoplasms; Carrier Proteins; Cell Line, Tumor; Cell Survival; Dacarbazine; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Folate Receptors, GPI-Anchored; Folic Acid; Humans; Inhibitory Concentration 50; O(6)-Methylguanine-DNA Methyltransferase; Receptors, Cell Surface; Temozolomide | 2007 |
Fatal outcome related to carmustine implants in glioblastoma multiforme.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Carmustine; Chemotherapy, Adjuvant; Dacarbazine; Drug Implants; Fatal Outcome; Female; Glioblastoma; Humans; Hydrocephalus; Magnetic Resonance Imaging; Male; Middle Aged; Neoplasm Recurrence, Local; Reoperation; Temozolomide; Temporal Lobe; Ventriculostomy | 2007 |
Dynamics of chemosensitivity and chromosomal instability in recurrent glioblastoma.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Line, Tumor; Chromosomal Instability; Dacarbazine; Drug Resistance, Neoplasm; Female; Glioblastoma; Humans; Middle Aged; Neoplasm Recurrence, Local; Nucleic Acid Hybridization; Temozolomide | 2007 |
The inhibition of proliferation and migration of glioma spheroids exposed to temozolomide is less than additive if combined with irradiation.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Movement; Cell Proliferation; Combined Modality Therapy; Dacarbazine; Glioma; Humans; Spheroids, Cellular; Temozolomide; Tumor Cells, Cultured | 2007 |
Hepatitis B reactivation during glioblastoma treatment with temozolomide: a cautionary note.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; DNA, Viral; Glioblastoma; Hepatitis B; Humans; Immunocompromised Host; Immunosuppression Therapy; Lamivudine; Liver; Male; Middle Aged; Patient Selection; Reverse Transcriptase Inhibitors; Risk Factors; Spinal Neoplasms; Temozolomide; Treatment Outcome; Viral Load; Virus Activation | 2007 |
Oncolytic herpes simplex virus mutants exhibit enhanced replication in glioma cells evading temozolomide chemotherapy through deoxyribonucleic acid repair.
Topics: Animals; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Culture Techniques; Cell Line, Tumor; Combined Modality Therapy; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; Genes, p53; Glioma; Humans; Mice; Mice, Nude; Oncolytic Virotherapy; Simplexvirus; Temozolomide; Tumor Suppressor Proteins | 2006 |
Loss of the mismatch repair protein MSH6 in human glioblastomas is associated with tumor progression during temozolomide treatment.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Proliferation; Dacarbazine; Disease Progression; DNA Modification Methylases; DNA Repair Enzymes; DNA-Binding Proteins; Female; Glioblastoma; Humans; Immunohistochemistry; Male; Middle Aged; Mutation; Neoplasm Recurrence, Local; Polymerase Chain Reaction; Temozolomide; Tumor Suppressor Proteins | 2007 |
Taming a mutinous mutant: an errant receptor becomes a prime cancer target.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Cancer Vaccines; Combined Modality Therapy; Dacarbazine; Glioblastoma; Humans; Mutation; Temozolomide | 2007 |
Temozolomide as prophylaxis for brain metastasis in non-small cell lung cancer.
Topics: Antineoplastic Agents, Alkylating; Antineoplastic Agents, Phytogenic; Brain Neoplasms; Camptothecin; Carcinoma, Non-Small-Cell Lung; Dacarbazine; Humans; Irinotecan; Lung Neoplasms; Temozolomide | 2006 |
Fatal reactivation of hepatitis B with temozolomide.
Topics: Aged; Anticonvulsants; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Fatal Outcome; Female; Glioblastoma; Hepatitis B; Hepatitis B virus; Humans; Temozolomide; Temporal Lobe; Valproic Acid; Viral Load; Virus Activation | 2007 |
A small proportion of glioblastoma patients are probably eligible for concomitant/adjuvant temozolomide.
Topics: Adjuvants, Immunologic; Antineoplastic Agents, Alkylating; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Glioblastoma; Humans; Practice Guidelines as Topic; State Medicine; Temozolomide; United Kingdom | 2007 |
Multiple gangliogliomas of the optic pathway.
Topics: Adolescent; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Ganglioglioma; Humans; Magnetic Resonance Imaging; Male; Optic Nerve Neoplasms; Temozolomide; Treatment Outcome; Vision Disorders | 2006 |
Methylguanine methyltransferase testing in glioblastoma: when and how?
Topics: Biomarkers, Tumor; Brain Neoplasms; Dacarbazine; Female; Glioblastoma; Humans; Male; Neoplasm Staging; O(6)-Methylguanine-DNA Methyltransferase; Prognosis; Retrospective Studies; Sensitivity and Specificity; Survival Rate; Temozolomide | 2007 |
Dynamic history of low-grade gliomas before and after temozolomide treatment.
Topics: Adult; Aged; Algorithms; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chromosomes; Dacarbazine; DNA, Neoplasm; Drug Resistance, Neoplasm; Female; Follow-Up Studies; Genes, p53; Glioma; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Molecular Biology; Temozolomide | 2007 |
Phosphatase and tensin homologue deficiency in glioblastoma confers resistance to radiation and temozolomide that is reversed by the protease inhibitor nelfinavir.
Topics: Animals; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; Drug Interactions; Drug Resistance, Neoplasm; Female; Glioblastoma; Humans; Mice; Mice, Nude; Nelfinavir; Phosphatidylinositol 3-Kinases; Protease Inhibitors; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Radiation Tolerance; Temozolomide | 2007 |
Adjuvant therapy in glioblastomas: false steps and real advances.
Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carmustine; Chemotherapy, Adjuvant; Dacarbazine; Decanoic Acids; Glioblastoma; Humans; Polyesters; Temozolomide | 2007 |
Magnetic resonance imaging determination of tumor grade and early response to temozolomide in a genetically engineered mouse model of glioma.
Topics: Animals; Brain Neoplasms; Dacarbazine; Disease Models, Animal; Genetic Engineering; Glioma; Magnetic Resonance Imaging; Mice; Mice, Mutant Strains; Neoplasm Invasiveness; Neoplasm Staging; Prognosis; Retroviridae; Temozolomide | 2007 |
Mathematical modeling of brain tumors: effects of radiotherapy and chemotherapy.
Topics: Antineoplastic Agents; Brain; Brain Neoplasms; Chemotherapy, Adjuvant; Clinical Trials as Topic; Combined Modality Therapy; Dacarbazine; Diffusion; Humans; Models, Statistical; Models, Theoretical; Radiation Oncology; Radiotherapy; Radiotherapy Dosage; Temozolomide; Time Factors | 2007 |
Unexpected case of aplastic anemia in a patient with glioblastoma multiforme treated with Temozolomide.
Topics: Adult; Anemia, Aplastic; Antineoplastic Agents, Alkylating; Blood Cell Count; Bone Marrow; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Fatal Outcome; Female; Glioblastoma; Humans; Magnetic Resonance Imaging; Pancytopenia; Sepsis; Temozolomide | 2007 |
Temozolomide for low-grade gliomas: predictive impact of 1p/19q loss on response and outcome.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chromosome Deletion; Chromosomes, Human, Pair 1; Chromosomes, Human, Pair 19; Dacarbazine; DNA Mutational Analysis; Drug Resistance, Neoplasm; Female; Gene Expression Regulation, Neoplastic; Genetic Testing; Genotype; Glioma; Humans; Loss of Heterozygosity; Male; Middle Aged; Neoplasm Recurrence, Local; Retrospective Studies; Survival Rate; Temozolomide; Treatment Outcome | 2007 |
Preferential migration of regulatory T cells mediated by glioma-secreted chemokines can be blocked with chemotherapy.
Topics: Antineoplastic Agents; Brain Neoplasms; Carmustine; Cell Line, Tumor; Chemokine CCL2; Chemokine CCL22; Chemokines; Chemotaxis, Leukocyte; Cytoplasm; Dacarbazine; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Glioma; Humans; Receptors, CCR2; Receptors, CCR4; T-Lymphocytes, Regulatory; Temozolomide | 2008 |
Complete response to temozolomide treatment in an elderly patient with recurrent primary central nervous system lymphoma--case report.
Topics: Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Female; Humans; Lymphoma, B-Cell; Neoplasm Recurrence, Local; Temozolomide; Treatment Outcome | 2007 |
Improved median survival for glioblastoma multiforme following introduction of adjuvant temozolomide chemotherapy.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemotherapy, Adjuvant; Dacarbazine; Female; Glioblastoma; Humans; Male; Middle Aged; Prospective Studies; Singapore; Survival Analysis; Temozolomide | 2007 |
Salvage chemotherapy in progressive high-grade astrocytoma.
Topics: Adult; Astrocytoma; Brain Neoplasms; Dacarbazine; Female; Glioblastoma; Humans; Male; Middle Aged; Retrospective Studies; Salvage Therapy; Singapore; Survival Analysis; Temozolomide | 2007 |
Inhibition of Aurora-B function increases formation of multinucleated cells in p53 gene deficient cells and enhances anti-tumor effect of temozolomide in human glioma cells.
Topics: Antineoplastic Agents, Alkylating; Aurora Kinase B; Aurora Kinases; Blotting, Western; Brain Neoplasms; Cell Cycle; Cell Survival; Dacarbazine; Flow Cytometry; Giant Cells; Glioma; Humans; Mutation; Protein Serine-Threonine Kinases; RNA, Small Interfering; Temozolomide; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2007 |
Temozolomide in pediatric low-grade glioma.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Carboplatin; Child; Child, Preschool; Dacarbazine; Disease-Free Survival; Female; Hematologic Diseases; Humans; Male; Nausea; Radiography; Retrospective Studies; Spinal Cord Neoplasms; Survival Rate; Temozolomide; Vincristine | 2007 |
Radiochemotherapy for brain metastasis: how to define a role for temozolomide.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Small Cell; Chemotherapy, Adjuvant; Clinical Trials, Phase II as Topic; Cranial Irradiation; Dacarbazine; Humans; Lung Neoplasms; Melanoma; Mouth Neoplasms; Neoplasms, Unknown Primary; Rectal Neoplasms; Research Design; Temozolomide; Treatment Outcome | 2007 |
Defining the standard of care for high-grade glioma--a NICE deal for UK patients?
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemotherapy, Adjuvant; Dacarbazine; Delivery of Health Care; Glioma; Humans; Temozolomide; United Kingdom | 2007 |
Biochemotherapy of metastatic melanoma in patients with or without recently diagnosed brain metastases.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Dacarbazine; Female; Humans; Infusions, Intravenous; Injections, Subcutaneous; Interferon alpha-2; Interferon-alpha; Interleukin-2; Male; Melanoma; Middle Aged; Patient Care Team; Radiosurgery; Recombinant Proteins; Retrospective Studies; Survival Analysis; Temozolomide; Treatment Outcome | 2007 |
Prophylactic radiotherapy for glioblastoma in the elderly.
Topics: Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Glioblastoma; Humans; Temozolomide | 2007 |
Predicting human tumor drug concentrations from a preclinical pharmacokinetic model of temozolomide brain disposition.
Topics: Animals; Antineoplastic Agents, Alkylating; Brain; Brain Neoplasms; Dacarbazine; Humans; Models, Animal; Rats; Temozolomide | 2007 |
The fallacy of single-agent chemotherapy for cancer.
Topics: Antineoplastic Agents, Alkylating; Biomarkers, Tumor; Brain Neoplasms; Dacarbazine; Glioblastoma; Humans; O(6)-Methylguanine-DNA Methyltransferase; Promoter Regions, Genetic; Sensitivity and Specificity; Temozolomide | 2007 |
Hemorrhagic cystitis in a patient receiving conventional doses of dacarbazine for metastatic malignant melanoma: case report and review of the literature.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Cystitis; Cystoscopy; Dacarbazine; Diagnosis, Differential; Dysuria; Fatal Outcome; Foot; Hematuria; Hemorrhage; Humans; Lung Neoplasms; Male; Melanoma; Middle Aged; Ultrasonography; Urinary Bladder | 2007 |
MS-MLPA: an attractive alternative laboratory assay for robust, reliable, and semiquantitative detection of MGMT promoter hypermethylation in gliomas.
Topics: Antineoplastic Agents, Alkylating; Base Sequence; Biopsy; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Gene Dosage; Gene Expression; Glioblastoma; Glioma; Humans; Immunohistochemistry; Molecular Sequence Data; Netherlands; Polymerase Chain Reaction; Promoter Regions, Genetic; Reproducibility of Results; Temozolomide; Tumor Suppressor Proteins | 2007 |
Efficacy of temozolomide is correlated with 1p loss and methylation of the deoxyribonucleic acid repair gene MGMT in malignant gliomas.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents, Alkylating; Biomarkers, Tumor; Brain Neoplasms; Chromosomes, Human, Pair 1; Chromosomes, Human, Pair 19; Dacarbazine; DNA Methylation; DNA Modification Methylases; DNA Mutational Analysis; DNA Repair; DNA Repair Enzymes; Drug Resistance, Neoplasm; Female; Genetic Markers; Genetic Predisposition to Disease; Genetic Testing; Glioma; Humans; Loss of Heterozygosity; Male; Middle Aged; Mutation; Promoter Regions, Genetic; Survival Rate; Temozolomide; Tumor Suppressor Proteins | 2007 |
Predictors of distant brain recurrence for patients with newly diagnosed brain metastases treated with stereotactic radiosurgery alone.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Dacarbazine; Female; Humans; Lung Neoplasms; Male; Melanoma; Middle Aged; Multivariate Analysis; Proportional Hazards Models; Radiosurgery; Retrospective Studies; Temozolomide | 2008 |
What approach will lead to cure of glioblastoma multiforme? In regard to Barani et al. (Int J Radiat Oncol Biol Phys 2007;68:324-333) and Jones and Sanghera (Int J Radiat Oncol Biol Phys 2007;68:441-448).
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Central Nervous System Neoplasms; Dacarbazine; Glioma; Humans; Radiotherapy Dosage; Relative Biological Effectiveness; Temozolomide; Therapeutic Equivalency; Tumor Burden | 2007 |
Bioluminescence monitoring of intracranial glioblastoma xenograft: response to primary and salvage temozolomide therapy.
Topics: Animals; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Disease Models, Animal; Glioblastoma; Luminescence; Luminescent Agents; Mice; Mice, Nude; Monitoring, Physiologic; Salvage Therapy; Temozolomide; Xenograft Model Antitumor Assays | 2007 |
Pharmacokinetic study of temozolomide on a daily-for-5-days schedule in Japanese patients with relapsed malignant gliomas: first study in Asians.
Topics: Administration, Oral; Adult; Antineoplastic Agents, Alkylating; Area Under Curve; Asian People; Brain Neoplasms; Dacarbazine; Drug Administration Schedule; Female; Glioma; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Prognosis; Temozolomide; White People | 2007 |
The unfolded protein response regulator GRP78/BiP as a novel target for increasing chemosensitivity in malignant gliomas.
Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Camptothecin; Caspase 7; Catechin; Cell Growth Processes; Cell Line, Tumor; Dacarbazine; Down-Regulation; Drug Screening Assays, Antitumor; Drug Synergism; Endoplasmic Reticulum Chaperone BiP; Fluorouracil; Glioblastoma; Heat-Shock Proteins; Humans; Irinotecan; Molecular Chaperones; RNA, Small Interfering; Temozolomide; Transcription Factor CHOP; Transfection | 2007 |
Adenovirally delivered tumor necrosis factor-alpha improves the antiglioma efficacy of concomitant radiation and temozolomide therapy.
Topics: Adenoviridae; Animals; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Line, Tumor; Combined Modality Therapy; Dacarbazine; DNA, Complementary; Female; Gene Transfer Techniques; Genetic Therapy; Glioma; Humans; Mice; Mice, Nude; Neoplasm Transplantation; Temozolomide; Time Factors; Treatment Outcome; Tumor Necrosis Factor-alpha | 2007 |
Defining the standard of care for high-grade glioma--a NICE deal for patients.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Glioblastoma; Humans; Temozolomide | 2008 |
Differential radiosensitizing potential of temozolomide in MGMT promoter methylated glioblastoma multiforme cell lines.
Topics: Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Combined Modality Therapy; Dacarbazine; DNA Methylation; Dose Fractionation, Radiation; Genes, Tumor Suppressor; Glioblastoma; Humans; Neoplasm Proteins; O(6)-Methylguanine-DNA Methyltransferase; Radiation Tolerance; Radiation-Sensitizing Agents; Temozolomide; Xenograft Model Antitumor Assays | 2007 |
Postoperative treatment of primary glioblastoma multiforme with radiation and concomitant temozolomide in elderly patients.
Topics: Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Female; Glioblastoma; Humans; Male; Survival Analysis; Temozolomide | 2008 |
Variation of O(6)-methylguanine-DNA methyltransferase (MGMT) promoter methylation in serial samples in glioblastoma.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Female; Glioblastoma; Humans; Immunohistochemistry; Male; Middle Aged; Polymerase Chain Reaction; Promoter Regions, Genetic; Temozolomide; Tumor Suppressor Proteins | 2008 |
Postoperative radiotherapy of glioblastoma multiforme: analysis and critical assessment of different treatment strategies and predictive factors.
Topics: Adult; Aged, 80 and over; Animals; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Biopsy; Brain Neoplasms; Chemotherapy, Adjuvant; Combined Modality Therapy; Craniotomy; Dacarbazine; Disease-Free Survival; Dose Fractionation, Radiation; Female; Glioblastoma; Humans; Infusions, Intravenous; Male; Middle Aged; Prognosis; Radiation Injuries; Radiotherapy, Adjuvant; Retrospective Studies; Salvage Therapy; Temozolomide; Topotecan | 2007 |
Diffusion tensor imaging and chemical shift imaging assessment of heterogeneity in low grade glioma under temozolomide chemotherapy.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Choline; Dacarbazine; Diffusion Magnetic Resonance Imaging; Glioma; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Temozolomide | 2007 |
Acquired hypopigmentation (leukoderma) as a presenting feature of metastatic amelanotic melanoma with brain involvement.
Topics: Anti-Inflammatory Agents; Antineoplastic Agents, Alkylating; Brain; Brain Neoplasms; Dacarbazine; Dexamethasone; Humans; Hypopigmentation; Immunoenzyme Techniques; Magnetic Resonance Imaging; Male; Melanoma, Amelanotic; Middle Aged; Neurologic Examination; Skin Neoplasms; Temozolomide | 2007 |
Encouraging experience of concomitant Temozolomide with radiotherapy followed by adjuvant Temozolomide in newly diagnosed glioblastoma multiforme: single institution experience.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemotherapy, Adjuvant; Dacarbazine; Disease-Free Survival; Drug Administration Schedule; Female; Follow-Up Studies; Glioblastoma; Humans; Karnofsky Performance Status; Male; Middle Aged; Survival Analysis; Temozolomide | 2007 |
Immunological responses in a patient with glioblastoma multiforme treated with sequential courses of temozolomide and immunotherapy: case study.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Cancer Vaccines; Combined Modality Therapy; Dacarbazine; ErbB Receptors; Flow Cytometry; Glioblastoma; Humans; Immunotherapy; Male; Middle Aged; Radiotherapy; T-Lymphocyte Subsets; T-Lymphocytes; Temozolomide; Vaccines, Subunit | 2008 |
Antiangiogenic compounds interfere with chemotherapy of brain tumors due to vessel normalization.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Blood-Brain Barrier; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; Disease Models, Animal; Humans; Mice; Neovascularization, Pathologic; Piperidines; Quinazolines; Temozolomide; Xenograft Model Antitumor Assays | 2008 |
Effects of the VEGFR inhibitor ZD6474 in combination with radiotherapy and temozolomide in an orthotopic glioma model.
Topics: Animals; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Brain; Brain Neoplasms; Cell Line, Tumor; Combined Modality Therapy; Dacarbazine; ErbB Receptors; Glioma; Neoplasm Transplantation; Piperidines; Quinazolines; Rats; Receptors, Vascular Endothelial Growth Factor; Reverse Transcriptase Polymerase Chain Reaction; Temozolomide | 2008 |
The added value of concurrently administered temozolomide versus adjuvant temozolomide alone in newly diagnosed glioblastoma.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Antineoplastic Protocols; Brain Neoplasms; Chemotherapy, Adjuvant; Cohort Studies; Combined Modality Therapy; Dacarbazine; Female; Glioblastoma; Humans; Male; Middle Aged; Multivariate Analysis; Retrospective Studies; Selection Bias; Survival Analysis; Temozolomide | 2008 |
[Treatment of marignant brain tumor: today and tomorrow].
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Cancer Vaccines; Dacarbazine; Genetic Therapy; Humans; Magnetic Resonance Imaging; Neurosurgical Procedures; Radiosurgery; Radiotherapy, Conformal; Temozolomide | 2008 |
In vitro and in vivo radiosensitization induced by the DNA methylating agent temozolomide.
Topics: Antineoplastic Agents, Alkylating; Apoptosis; Brain Neoplasms; Cell Cycle; Cell Line, Tumor; Dacarbazine; DNA Methylation; DNA Replication; Glioblastoma; Humans; Mitosis; Radiation-Sensitizing Agents; Temozolomide; Tumor Stem Cell Assay | 2008 |
Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma in elderly patients.
Topics: Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemotherapy, Adjuvant; Combined Modality Therapy; Dacarbazine; Female; Glioblastoma; Humans; Karnofsky Performance Status; Male; Neurosurgical Procedures; Survival; Temozolomide | 2008 |
[Chemotherapy for brain tumors in adult patients].
Topics: Adult; Antineoplastic Agents; Brain Neoplasms; Chemotherapy, Adjuvant; Chromosomes, Human, Pair 1; Chromosomes, Human, Pair 19; Combined Modality Therapy; Dacarbazine; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Genetic Markers; Glioma; Humans; Lymphoma; Prognosis; Promoter Regions, Genetic; Temozolomide; Topotecan; Tumor Suppressor Proteins | 2008 |
Astroblastoma with rhabdoid features and favorable long-term outcome: report of a case with a 12-year follow-up.
Topics: Antibodies, Antinuclear; Antibodies, Monoclonal; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Differentiation; Cerebral Angiography; Chemotherapy, Adjuvant; Craniotomy; Dacarbazine; Glial Fibrillary Acidic Protein; Humans; Ki-67 Antigen; Magnetic Resonance Imaging; Male; Middle Aged; Neoplasm Recurrence, Local; Neoplasms, Neuroepithelial; Parietal Lobe; Radiotherapy, Adjuvant; Reoperation; Rhabdoid Tumor; Temozolomide; Time Factors; Treatment Outcome; Vimentin | 2008 |
Treatment of recurrent glioblastoma: can local delivery of mitoxantrone improve survival?
Topics: Adult; Aged; Aging; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Disease Progression; Female; Glioblastoma; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Mitoxantrone; Neoplasm Recurrence, Local; Neurosurgical Procedures; Positron-Emission Tomography; Retrospective Studies; Survival; Temozolomide; Treatment Outcome | 2008 |
Evidence of galectin-1 involvement in glioma chemoresistance.
Topics: Animals; Antineoplastic Agents; Apoptosis; Autophagy; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; Drug Resistance, Neoplasm; Endoplasmic Reticulum Chaperone BiP; Galectin 1; Glioma; Humans; Mice; RNA, Small Interfering; Temozolomide; Tumor Suppressor Protein p53 | 2008 |
Complete response after one cycle of temozolomide in an elderly patient with glioblastoma and poor performance status.
Topics: Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chromosome Deletion; Chromosomes, Human, X; Dacarbazine; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Female; Glioblastoma; Humans; Temozolomide; Tomography, X-Ray Computed; Tumor Suppressor Proteins | 2008 |
[Temozolomide: Temodal].
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Clinical Trials as Topic; Dacarbazine; Glioblastoma; Humans; Magnetic Resonance Imaging; Male; Temozolomide | 2008 |
Glioblastoma in a patient with a hereditary cancer syndrome.
Topics: Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cerebral Hemorrhage; Colorectal Neoplasms; Combined Modality Therapy; Dacarbazine; Glioblastoma; Headache; Humans; International Normalized Ratio; Male; Neurosurgical Procedures; Pedigree; Temozolomide; Tomography, X-Ray Computed | 2008 |
A retrospective study of the safety of BCNU wafers with concurrent temozolomide and radiotherapy and adjuvant temozolomide for newly diagnosed glioblastoma patients.
Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carmustine; Chemotherapy, Adjuvant; Combined Modality Therapy; Dacarbazine; Drug Implants; Glioblastoma; Humans; Kaplan-Meier Estimate; Radiotherapy; Retrospective Studies; Temozolomide | 2008 |
[The sodium pump could constitute a new target to combat glioblastomas].
Topics: Animals; Antineoplastic Agents, Alkylating; Antineoplastic Agents, Phytogenic; Apoptosis; Autophagy; Brain Neoplasms; Calotropis; Cardenolides; Cell Movement; Cell Proliferation; Combined Modality Therapy; Dacarbazine; Drug Screening Assays, Antitumor; Glioblastoma; Humans; Mice; Neoplasm Invasiveness; Neoplasm Proteins; Neovascularization, Pathologic; Signal Transduction; Sodium-Potassium-Exchanging ATPase; Temozolomide | 2008 |
Comparative evaluation of radiochemotherapy with temozolomide versus standard-of-care postoperative radiation alone in patients with WHO grade III astrocytic tumors.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Child; Combined Modality Therapy; Dacarbazine; Disease Progression; Female; Humans; Male; Middle Aged; Proportional Hazards Models; Retrospective Studies; Survival Analysis; Temozolomide; Treatment Outcome | 2008 |
Low grade astrocytoma presenting with visual loss.
Topics: Adolescent; Antineoplastic Agents, Alkylating; Astrocytoma; Biomarkers, Tumor; Brain Neoplasms; Dacarbazine; ErbB Receptors; Humans; Intracranial Hypertension; Magnetic Resonance Imaging; Male; Neoplasm Metastasis; Optic Nerve; Optic Nerve Neoplasms; Papilledema; Phosphatidylinositol 3-Kinases; PTEN Phosphohydrolase; Spinal Cord Neoplasms; Subarachnoid Space; Temozolomide; Thalamus; Vision, Low | 2008 |
Cryptococcal meningitis in patients with glioma: a report of two cases.
Topics: Adult; Aged; Amphotericin B; Anti-Inflammatory Agents; Antifungal Agents; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cerebrospinal Fluid; Cryptococcus neoformans; Dacarbazine; Dexamethasone; Fatal Outcome; Fluconazole; Flucytosine; Glioma; Humans; Immunosuppression Therapy; Lomustine; Male; Meningitis, Cryptococcal; Opportunistic Infections; Temozolomide; Treatment Outcome | 2008 |
[Glioblastomas are resistant to apoptosis but less resistant to the autophagic process].
Topics: Algorithms; Antibiotics, Antineoplastic; Antineoplastic Agents, Alkylating; Apoptosis; Autophagy; Brain Neoplasms; Cell Movement; Clinical Trials as Topic; Dacarbazine; Forecasting; Glioblastoma; Humans; Prognosis; Sirolimus; Temozolomide; Transcription Factors | 2007 |
Multifocal glioblastoma multiforme with synchronous spontaneous hemorrhage: case report.
Topics: Aged; Antineoplastic Agents, Alkylating; Biomarkers, Tumor; Biopsy; Brain Neoplasms; Cerebral Hemorrhage; Cerebrum; Dacarbazine; Glial Fibrillary Acidic Protein; Glioblastoma; Humans; Male; Neoplasms, Multiple Primary; Paresis; Radiotherapy; Temozolomide; Tomography, X-Ray Computed; Treatment Outcome | 2008 |
Knocking down galectin 1 in human hs683 glioblastoma cells impairs both angiogenesis and endoplasmic reticulum stress responses.
Topics: Animals; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; Down-Regulation; Endoplasmic Reticulum; Endoplasmic Reticulum Chaperone BiP; Endoribonucleases; Female; Galectin 1; Gene Expression Regulation, Neoplastic; Gene Silencing; Genetic Therapy; Glioblastoma; HSP40 Heat-Shock Proteins; HSP70 Heat-Shock Proteins; Humans; Membrane Proteins; Mice; Molecular Chaperones; Neovascularization, Pathologic; Oxidative Stress; Protein Serine-Threonine Kinases; Proteins; RNA Interference; RNA, Small Interfering; Signal Transduction; Temozolomide; Transplantation, Heterologous | 2008 |
Modulatory effects of acetazolomide and dexamethasone on temozolomide-mediated apoptosis in human glioblastoma T98G and U87MG cells.
Topics: Acetazolamide; Apoptosis; Aquaporin 1; Brain Edema; Brain Neoplasms; Calpain; Carbonic Anhydrases; Caspases; Cell Line, Tumor; Dacarbazine; Dexamethasone; Drug Interactions; Drug Screening Assays, Antitumor; Glioblastoma; Humans; Inflammation; Mitochondria; Neoplasm Proteins; NF-kappa B; RNA, Messenger; RNA, Neoplasm; Temozolomide; Vascular Endothelial Growth Factor A | 2008 |
MGMT promoter methylation status can predict the incidence and outcome of pseudoprogression after concomitant radiochemotherapy in newly diagnosed glioblastoma patients.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Diseases; Brain Neoplasms; Chemotherapy, Adjuvant; Dacarbazine; Disease Progression; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Female; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Genetic Predisposition to Disease; Glioblastoma; Humans; Kaplan-Meier Estimate; Magnetic Resonance Imaging; Male; Middle Aged; Necrosis; Patient Selection; Promoter Regions, Genetic; Proportional Hazards Models; Radiation Injuries; Radiotherapy, Adjuvant; Retrospective Studies; Temozolomide; Time Factors; Treatment Outcome; Tumor Suppressor Proteins | 2008 |
Malignant gliomas with primitive neuroectodermal tumor-like components: a clinicopathologic and genetic study of 53 cases.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Female; Follow-Up Studies; Genes, myc; Glioma; Humans; In Situ Hybridization, Fluorescence; Medulloblastoma; Neoplasm Metastasis; Neoplasms, Multiple Primary; Neuroectodermal Tumors, Primitive; Prognosis; Proto-Oncogene Proteins; Radiotherapy; Temozolomide; Treatment Outcome; Young Adult | 2009 |
Adjuvant temozolomide: how long and how much?
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemotherapy, Adjuvant; Dacarbazine; Drug Administration Schedule; Glioblastoma; Humans; Neoplasm Recurrence, Local; Survival Analysis; Temozolomide | 2008 |
Enhancement of glioma radiotherapy and chemotherapy response with targeted antibody therapy against death receptor 5.
Topics: Animals; Antibodies, Monoclonal; Antineoplastic Agents, Alkylating; Apoptosis; Brain Neoplasms; Cell Line, Tumor; Combined Modality Therapy; Dacarbazine; Glioma; Humans; Mice; Mice, Nude; Random Allocation; Receptors, TNF-Related Apoptosis-Inducing Ligand; Temozolomide; Xenograft Model Antitumor Assays | 2008 |
Radiation therapy for brain metastases from malignant melanoma.
Topics: Adult; Aged; Brain Neoplasms; Dacarbazine; Dose-Response Relationship, Radiation; Female; Humans; Lomustine; Male; Melanoma; Middle Aged; Prognosis | 1984 |
Treatment of malignant melanoma with dacarbazin (DTIC-DOME) with special reference to urinary excretion of 5-S-cysteinyldopa.
Topics: Adult; Aged; Brain Neoplasms; Cysteinyldopa; Dacarbazine; Digestive System; Dihydroxyphenylalanine; Female; Humans; Infusions, Intra-Arterial; Male; Melanoma; Middle Aged; Palliative Care; Remission, Spontaneous | 1980 |
Infiltration of liver and brain by tumor cells in leukemic mice: prevention by dimethyltriazenes and cyclophosphamide.
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Cyclophosphamide; Dacarbazine; Leukemia, Experimental; Liver Neoplasms; Mice; Triazenes | 1984 |
Intracerebral adoptive immunotherapy of a murine lymphoma antigenically altered by drug treatment in vivo.
Topics: Animals; Blood Transfusion; Brain Neoplasms; Dacarbazine; Immunization; Lymphoma; Mice; Mice, Inbred Strains; Neoplasm Transplantation; Neoplasms, Experimental; T-Lymphocytes; Whole-Body Irradiation | 1982 |
Chemoimmunotherapy for disseminated malignant melanoma with DTIC, ACNU, VCR and OK432. Case presentation of two complete and one partial reponse out of fifteen attempts.
Topics: Adjuvants, Immunologic; Adult; Antineoplastic Agents; Brain Neoplasms; Dacarbazine; Drug Therapy, Combination; Female; Humans; Male; Melanoma; Nimustine; Nitrosourea Compounds; Picibanil; Skin Neoplasms; Vincristine | 1982 |
The frequency of isolated CNS involvement in Ewing's sarcoma.
Topics: Adolescent; Adult; Brain Neoplasms; Child; Cyclophosphamide; Dacarbazine; Dactinomycin; Doxorubicin; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Meningeal Neoplasms; Radiotherapy Dosage; Sarcoma, Ewing; Vincristine | 1982 |
[Malignant melanoma of the esophagus (author's transl)].
Topics: Adult; BCG Vaccine; Brain Neoplasms; Dacarbazine; Esophageal Neoplasms; Humans; Male; Melanoma; Seizures | 1981 |
Chemotherapy against human melanoma in the hamster cheek pouch.
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Carmustine; Cheek; Cricetinae; Cyclophosphamide; Dacarbazine; Doxorubicin; Fluorouracil; Humans; Male; Melanoma; Methotrexate; Middle Aged; Neoplasm Transplantation; Neoplasms, Experimental; Vincristine | 1980 |
Symptoms of occult brain metastases initiated by systemic Dacarbazine (DTIC-DOME) therapy in melanoma patients.
Topics: Adult; Aged; Brain Neoplasms; Dacarbazine; Dizziness; Female; Headache; Humans; Male; Melanoma; Middle Aged | 1980 |
Preclinical antitumor activity of temozolomide in mice: efficacy against human brain tumor xenografts and synergism with 1,3-bis(2-chloroethyl)-1-nitrosourea.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carmustine; Dacarbazine; Humans; Methyltransferases; Mice; Neoplasm Transplantation; O(6)-Methylguanine-DNA Methyltransferase; Temozolomide; Tumor Cells, Cultured | 1994 |
Brain metastases of metastatic malignant melanoma: response to DTIC and interferon-gamma.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Dacarbazine; Female; Humans; Interferon-gamma; Melanoma; Remission Induction | 1993 |
From triazines and triazenes to temozolomide.
Topics: Animals; Antineoplastic Agents; Astrocytoma; Brain Neoplasms; Chemistry, Pharmaceutical; Dacarbazine; Humans; Melanoma; Mice; Nitrogen Mustard Compounds; Prodrugs; Temozolomide | 1993 |
Uptake of temozolomide in a rat glioma model in the presence and absence of the angiogenesis inhibitor TNP-470.
Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cyclohexanes; Dacarbazine; Factor VIII; Glioma; Microscopy, Confocal; Neoplasm Transplantation; Neovascularization, Pathologic; O-(Chloroacetylcarbamoyl)fumagillol; Rats; Sesquiterpenes; Temozolomide; Tumor Cells, Cultured | 1996 |
[Acquired myelodysplastic syndromes after treatment of melanoma with fotemustine and dacarbazine].
Topics: Aged; Antineoplastic Agents; Brain Neoplasms; Dacarbazine; Drug Therapy, Combination; Fatal Outcome; Female; Humans; Melanoma; Middle Aged; Myelodysplastic Syndromes; Nitrosourea Compounds; Organophosphorus Compounds; Skin Neoplasms | 1995 |
In vitro evaluation of temozolomide combined with X-irradiation.
Topics: Adenocarcinoma; Antineoplastic Agents, Alkylating; Brain Neoplasms; Colonic Neoplasms; Combined Modality Therapy; Dacarbazine; DNA Adducts; DNA Repair; Glioblastoma; Humans; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Temozolomide; Tumor Cells, Cultured | 1997 |
Syndrome of inappropriate secretion of antidiuretic hormone in a patient affected by metastatic melanoma.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Disease Progression; Facial Neoplasms; Fatal Outcome; Frontal Lobe; Humans; Inappropriate ADH Syndrome; Lymphatic Metastasis; Male; Melanoma; Middle Aged | 1998 |
Activity of temozolomide against human tumor colony-forming units.
Topics: Adrenal Gland Neoplasms; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Brain Neoplasms; Breast Neoplasms; Cell Division; Dacarbazine; Digestive System Neoplasms; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Female; Hematologic Neoplasms; Humans; Lung Neoplasms; Neoplasm Proteins; Neoplastic Stem Cells; O(6)-Methylguanine-DNA Methyltransferase; Temozolomide; Tumor Cells, Cultured; Tumor Stem Cell Assay; Urogenital Neoplasms | 1997 |
Role of O6-methylguanine-DNA methyltransferase in resistance of human brain tumor cell lines to the clinically relevant methylating agents temozolomide and streptozotocin.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Drug Resistance, Neoplasm; Guanine; Humans; Methyl Methanesulfonate; Methylation; Methylnitronitrosoguanidine; O(6)-Methylguanine-DNA Methyltransferase; Streptozocin; Temozolomide; Tumor Cells, Cultured | 1996 |
DNA mismatch repair and O6-alkylguanine-DNA alkyltransferase analysis and response to Temodal in newly diagnosed malignant glioma.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; DNA Repair; DNA, Neoplasm; Drug Administration Schedule; Female; Glioblastoma; Humans; Imidazoles; Male; Middle Aged; O(6)-Methylguanine-DNA Methyltransferase; Predictive Value of Tests; Temozolomide; Treatment Outcome | 1998 |
[A case of metastatic liposarcoma originating in the retroperitoneum successfully treated with combination chemotherapy].
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cyclophosphamide; Dacarbazine; Doxorubicin; Drug Administration Schedule; Female; Humans; Liposarcoma; Lung Neoplasms; Remission Induction; Retroperitoneal Neoplasms; Vincristine | 1999 |
Sensitivity of short-term cultures derived from human malignant glioma to the anti-cancer drug temozolomide.
Topics: Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Dacarbazine; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Glioblastoma; Humans; Inhibitory Concentration 50; Lomustine; Oligodendroglioma; Temozolomide; Tumor Cells, Cultured | 1999 |
Management of cerebral metastases from malignant melanoma: results of a combined, simultaneous treatment with fotemustine and irradiation.
Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Dacarbazine; Female; Humans; Lymphatic Metastasis; Male; Melanoma; Middle Aged; Neoplasm Metastasis; Nitrosourea Compounds; Organophosphorus Compounds; Retrospective Studies; Survival Analysis | 1999 |
Oral temozolomide approved for refractory brain tumor.
Topics: Administration, Oral; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Dacarbazine; Drug Administration Schedule; Humans; Temozolomide | 1999 |
Biochemical correlates of temozolomide sensitivity in pediatric solid tumor xenograft models.
Topics: Adaptor Proteins, Signal Transducing; Animals; Antineoplastic Agents, Alkylating; Base Pair Mismatch; Brain Neoplasms; Carrier Proteins; Cell Division; Child; Dacarbazine; DNA Repair; DNA-Binding Proteins; Female; Humans; Mice; Mice, Inbred CBA; MutL Protein Homolog 1; MutS Homolog 2 Protein; Neoplasm Proteins; Neoplasm Transplantation; Neoplasms, Experimental; Neuroblastoma; Nuclear Proteins; O(6)-Methylguanine-DNA Methyltransferase; Phenotype; Proto-Oncogene Proteins; Rhabdomyosarcoma; Temozolomide; Transplantation, Heterologous; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2000 |
Salvage therapy with temozolomide in an immunocompetent patient with primary brain lymphoma.
Topics: Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Humans; Immunocompetence; Lymphoma, B-Cell; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Magnetic Resonance Imaging; Male; Salvage Therapy; Temozolomide; Treatment Outcome | 2000 |
Temozolomide (Temodal) for treatment of primary brain tumours.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Drug Monitoring; Glioblastoma; Humans; Prognosis; Survival Analysis; Temozolomide; Treatment Outcome | 2000 |
Temozolomide for malignant brain tumours.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Clinical Trials as Topic; Dacarbazine; Glioblastoma; Glioma; Humans; Temozolomide; United States | 2000 |
Survival of human glioma cells treated with various combination of temozolomide and X-rays.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Survival; Combined Modality Therapy; Dacarbazine; Glioma; Humans; Temozolomide; Tumor Cells, Cultured; Tumor Stem Cell Assay | 2000 |
Temozolomide for refractory anaplastic astrocytoma.
Topics: Administration, Oral; Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Clinical Trials as Topic; Dacarbazine; DNA Replication; Dose-Response Relationship, Drug; Fees, Pharmaceutical; Humans; Multicenter Studies as Topic; Temozolomide | 1999 |
Antitumor activity of temozolomide combined with irinotecan is partly independent of O6-methylguanine-DNA methyltransferase and mismatch repair phenotypes in xenograft models.
Topics: Administration, Oral; Alkylating Agents; Animals; Antineoplastic Agents, Alkylating; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Base Pair Mismatch; Brain Neoplasms; Camptothecin; Dacarbazine; DNA Repair; Female; Glioblastoma; Irinotecan; Mice; Mice, Inbred CBA; Neoplasm Transplantation; Neuroblastoma; O(6)-Methylguanine-DNA Methyltransferase; Phenotype; Rhabdomyosarcoma; Temozolomide; Time Factors | 2000 |
Temozolomide delivered by intracerebral microinfusion is safe and efficacious against malignant gliomas in rats.
Topics: Animals; Antineoplastic Agents, Alkylating; Brain; Brain Neoplasms; Catheterization; Catheters, Indwelling; Dacarbazine; Drug Delivery Systems; Glioma; Humans; Male; Neoplasm Transplantation; Rats; Rats, Nude; Temozolomide; Time Factors; Tumor Cells, Cultured | 2000 |
Effects of temozolomide in malignant brain tumours.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Dacarbazine; Glioma; Humans; Quality of Life; Temozolomide | 2000 |
Synergy between methionine stress and chemotherapy in the treatment of brain tumor xenografts in athymic mice.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carbon-Sulfur Lyases; Carmustine; Choline; Dacarbazine; Diet; Down-Regulation; Drug Synergism; Glioblastoma; Humans; Methionine; Mice; Mice, Inbred BALB C; Mice, Nude; O(6)-Methylguanine-DNA Methyltransferase; Recombinant Proteins; Temozolomide; Xenograft Model Antitumor Assays | 2001 |
An Australian experience with temozolomide for the treatment of recurrent high grade gliomas.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Australia; Brain Neoplasms; Dacarbazine; Disease-Free Survival; Female; Glioma; Humans; Male; Middle Aged; Retrospective Studies; Temozolomide; Treatment Outcome | 2001 |
Temozolomide chemotherapy in recurrent oligodendroglioma.
Topics: Adult; Antineoplastic Agents; Brain Neoplasms; Dacarbazine; Humans; Middle Aged; Neoplasm Recurrence, Local; Oligodendroglioma; Temozolomide; Time Factors | 2001 |
Treatment of brain metastases of malignant melanoma with temozolomide.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Humans; Lung Neoplasms; Magnetic Resonance Imaging; Male; Melanoma; Middle Aged; Skin Neoplasms; Temozolomide | 2001 |
Temozolomide enhances herpes simplex virus thymidine kinase/ganciclovir therapy of malignant glioma.
Topics: Animals; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Division; Dacarbazine; Drug Interactions; Drug Synergism; Ganciclovir; Genetic Therapy; Glioma; Humans; Male; Mice; Mice, Nude; Neoplasm Transplantation; Simplexvirus; Temozolomide; Thymidine Kinase; Tumor Cells, Cultured | 2001 |
Possible efficacy of temozolomide in a patient with gliomatosis cerebri.
Topics: Adult; Antineoplastic Agents, Alkylating; Brain; Brain Neoplasms; Dacarbazine; Humans; Magnetic Resonance Imaging; Male; Neoplasms, Neuroepithelial; Temozolomide; Treatment Outcome | 2001 |
Brain metastases from fallopian tube carcinoma responsive to intra-arterial carboplatin and intravenous etoposide: a case report.
Topics: Adenocarcinoma, Papillary; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Brain Stem; Carboplatin; Carotid Arteries; Cisplatin; Combined Modality Therapy; Cranial Irradiation; Cyclophosphamide; Dacarbazine; Etoposide; Fallopian Tube Neoplasms; Fallopian Tubes; Female; Humans; Infusions, Intra-Arterial; Infusions, Intravenous; Magnetic Resonance Imaging; Middle Aged; Paclitaxel; Physical Examination; Rupture, Spontaneous; Temozolomide; Temporal Lobe; Vertebral Artery | 2001 |
NICE verdict on Temozolomide: where next?
Topics: Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Dacarbazine; Disease-Free Survival; Drug Approval; Evidence-Based Medicine; Glioblastoma; Humans; Survival Rate; Temozolomide; Treatment Outcome | 2002 |
Treatment of metastatic melanoma in the brain with temozolomide and thalidomide.
Topics: Adult; Angiogenesis Inhibitors; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Drug Therapy, Combination; Female; Frontal Lobe; Humans; Melanoma; Remission Induction; Temozolomide; Thalidomide | 2001 |
[An autopsy case of pulmonary and central nervous system metastatic osteosarcoma treated with thirty-six courses of chemotherapy over four years].
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Brain Neoplasms; Carboplatin; Cisplatin; Dacarbazine; Deoxycytidine; Docetaxel; Drug Administration Schedule; Etoposide; Gemcitabine; Humans; Ifosfamide; Lung Neoplasms; Male; Methotrexate; Osteosarcoma; Paclitaxel; Spinal Cord Neoplasms; Survivors; Taxoids; Vincristine; Vindesine | 2002 |
Temozolomide-induced flare in high-grade gliomas: a new clinical entity.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Dacarbazine; Female; Glioblastoma; Glioma; Humans; Karnofsky Performance Status; Male; Middle Aged; Prognosis; Retrospective Studies; Risk Factors; Severity of Illness Index; Temozolomide | 2002 |
Phase 1-11 study of DTIC and cyclocytidine in disseminated malignant melanoma.
Topics: Adult; Aged; Ancitabine; Brain Neoplasms; Cytarabine; Dacarbazine; Drug Therapy, Combination; Humans; Liver Neoplasms; Lung Neoplasms; Melanoma; Middle Aged; Neoplasm Metastasis; Retroperitoneal Neoplasms; Skin Neoplasms; Triazenes | 1976 |
Treatment of grade III and IV astrocytoma with dimethyl triazeno imidazole carboxamide (DTIC, NSC-45388) alone and in combination with CCNU (NSC-79037) or methyl CCNU (MeCCNU, NSC-95441).
Topics: Adult; Brain Neoplasms; Dacarbazine; Drug Evaluation; Drug Therapy, Combination; Female; Glioblastoma; Humans; Leukopenia; Lomustine; Male; Methylnitrosourea; Middle Aged; Thrombocytopenia; Triazenes | 1975 |
Increased incidence of cerebral metastases in sarcoma patients with prolonged survival from chemotherapy. Report of cases of leiomysarcoma and chondrosarcoma.
Topics: Adult; Brain Neoplasms; Chondrosarcoma; Dacarbazine; Doxorubicin; Drug Therapy, Combination; Female; Humans; Leiomyosarcoma; Male; Middle Aged; Neoplasm Metastasis | 1975 |
Cerebral metastatic melanoma: correlation between clinical and CT findings.
Topics: Adult; Aged; Antineoplastic Agents; Brain Neoplasms; Dacarbazine; Female; Humans; Male; Melanoma; Middle Aged; Nitrosourea Compounds; Organophosphorus Compounds; Tomography, X-Ray Computed | 1992 |
[Primary intracranial melanoma: a case report].
Topics: Adult; Amphetamines; Antineoplastic Combined Chemotherapy Protocols; Brain; Brain Neoplasms; Dacarbazine; Diagnosis, Differential; Humans; Interferon-beta; Iodine Radioisotopes; Iofetamine; Magnetic Resonance Imaging; Male; Melanoma; Nimustine; Prognosis; Tomography, Emission-Computed, Single-Photon; Vincristine | 1992 |
Dacarbazine (DTIC), human recombinant interferon alpha 2a (Roferon) and 5-fluorouracil for disseminated malignant melanoma.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Dacarbazine; Drug Administration Schedule; Female; Fluorouracil; Humans; Interferon-alpha; Male; Melanoma; Middle Aged | 1992 |
Fotemustine with or without dacarbazine for brain metastases of malignant melanoma.
Topics: Adult; Aged; Antineoplastic Agents; Brain Neoplasms; Dacarbazine; Drug Evaluation; Humans; Melanoma; Middle Aged; Nitrosourea Compounds; Organophosphorus Compounds | 1991 |
Mesna, doxorubicin, ifosfamide, dacarbazine (MAID) regimen for adults with advanced sarcoma.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; Doxorubicin; Drug Evaluation; Female; Humans; Ifosfamide; Lung Neoplasms; Male; Mesna; Middle Aged; Remission Induction; Sarcoma; Survival Rate | 1990 |
Chemotherapy for aggressive juvenile nasopharyngeal angiofibroma.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cisplatin; Combined Modality Therapy; Cyclophosphamide; Dacarbazine; Dactinomycin; Doxorubicin; Follow-Up Studies; Histiocytoma, Benign Fibrous; Humans; Male; Nasopharyngeal Neoplasms; Neoplasm Invasiveness; Neoplasm Recurrence, Local; Tomography, X-Ray Computed; Vincristine | 1985 |
Eight drugs in one day chemotherapy for brain tumors: experience in 107 children and rationale for preradiation chemotherapy.
Topics: Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Child; Cisplatin; Combined Modality Therapy; Cyclophosphamide; Cytarabine; Dacarbazine; Drug Evaluation; Glioblastoma; Humans; Hydroxyurea; Lomustine; Medulloblastoma; Methylprednisolone; Neoplasm Recurrence, Local; Procarbazine; Vincristine | 1987 |
Metastatic liposarcoma of the brain with response to chemotherapy: case report.
Topics: Brain Neoplasms; Dacarbazine; Doxorubicin; Female; Humans; Leg; Liposarcoma; Middle Aged; Soft Tissue Neoplasms | 1988 |
[Efficacy of the "8 drugs in a day" protocol in brain tumors in children].
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Cerebellar Neoplasms; Child; Child, Preschool; Cytarabine; Cytidine Diphosphate Diglycerides; Dacarbazine; Female; Glioma; Humans; Hydroxyurea; Infant; Lomustine; Male; Medulloblastoma; Methylprednisolone; Procarbazine; Vincristine | 1988 |
Sequential treatment with interferon and chemotherapy of metastatic malignant melanoma. Total remission of cutaneous and visceral metastasis, but not of cerebral metastasis.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Brain Neoplasms; Carmustine; Combined Modality Therapy; Dacarbazine; Drug Evaluation; Female; Humans; Interferon Type I; Lomustine; Lymphatic Metastasis; Male; Melanoma; Middle Aged; Recombinant Proteins; Skin Neoplasms; Vincristine | 1987 |
Very high dose cyclophosphamide with imidazole carboximide and vincristine sulfate in the treatment of stage IV neuroblastoma.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Child; Child, Preschool; Cyclophosphamide; Dacarbazine; Drug Administration Schedule; Drug Evaluation; Female; Humans; Infant; Male; Neuroblastoma; Vincristine | 1985 |