dacarbazine has been researched along with B16 Melanoma in 67 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 1 (1.49) | 18.7374 |
1990's | 8 (11.94) | 18.2507 |
2000's | 20 (29.85) | 29.6817 |
2010's | 33 (49.25) | 24.3611 |
2020's | 5 (7.46) | 2.80 |
Authors | Studies |
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Bhardwaj, A; Fei, Y; Huang, Z; Kaur, J; Knaus, EE; Wu, J; Yuan, H; Zhang, Y; Zou, Y | 1 |
Cecchini, AL; Cecchini, R; da Silva Brito, WA; Lopes, NMD; Luiz, RC; Marinello, PC; Sanches, LJ | 1 |
Brusco, I; Camponogara, C; Chiepe, KB; da Silva Brum, E; de Almeida, AS; de Andrade, VM; de David Antoniazzi, CT; De Logu, F; Ferreira, J; Geppetti, P; Li Puma, S; Nassini, R; Oliveira, SM; Silva, CR; Trevisan, G | 1 |
Li, L; Qian, Z; Qiu, L; Zhang, H; Zhao, P; Zhou, S | 1 |
Da-Costa-Rocha, I; Prieto, JM | 1 |
Amakye, WK; Liu, H; Ren, J | 1 |
Amson, R; Appel, MH; Basílio, AB; Boia-Ferreira, M; Chaim, OM; Da Costa, CRV; Hamasaki, AE; Matsubara, FH; Senff-Ribeiro, A; Telerman, A; Veiga, SS | 1 |
Aiba, S; Fujimura, T; Furudate, S; Kakizaki, A; Kambayashi, Y; Lyu, C; Sato, Y; Tanita, K | 1 |
Hafeez, A; Kazmi, I | 1 |
Caruntu, C; Constantin, C; Neagu, M; Surcel, M; Zurac, S | 1 |
Annovazzi, L; Battaglia, L; Biasibetti, E; Boggio, E; Cangemi, L; Capucchio, MT; Clemente, N; Dianzani, C; Dianzani, U; Ferrara, B; Gigliotti, CL; Mellai, M; Miglio, G; Muntoni, E; Schiffer, D | 1 |
Cui, H; Huang, W; Li, X; Liao, X; Liu, X; Min, L; Shi, B; Sun, X; Xu, S; Yang, J; Zhang, M; Zheng, H; Zhu, Z | 1 |
Banerjee, S; Bhattacharyya, S; Biswas, N; Majumder, B; Mitra, D; Murmu, N; Mustafi, SM; Ray, S | 1 |
Ali, N; Banerjee, I; Bharti, R; Chakrabarti, P; Chattopadhyay, S; De, M; Dey, G; Kundu, SC; Mandal, M; Reis, RL | 1 |
Imano, M; Kawashima, K; Nishida, S; Obata, N; Satou, T; Tabata, M; Takeda, T; Tsubaki, M | 1 |
Choi, YW; Kim, J; Lee, M; Lee, O; Oh, C; Park, G | 1 |
Iannone, R; Maiolino, P; Miele, L; Morello, S; Pinto, A | 1 |
Castioni, N; Elia, G; Neri, D; Pretto, F | 1 |
Amatulli, M; Balderes, P; Brennan, L; Burtrum, D; Credille, KM; Damoci, CB; DeLigio, JT; Duignan, IJ; Kotanides, H; Lebron, MB; Loizos, N; O'Mahony, M; Paz, K; Persaud, K; Prewett, MC; Schwartz, KD; Starodubtseva, M; Surguladze, D; Zhang, Y | 1 |
Fietkau, R; Frey, B; Gaipl, US; Werthmöller, N; Wunderlich, R | 1 |
Basseville, A; Levine, M; Parrow, NL; Serrano, OK; Violet, PC; Yang, J; Zornjak, J | 1 |
Imamura, R; Itoh, T; Kawada, A; Kawai, S; Koyama, A; Matsuo, K; Nakayama, T; Nishiwaki, K; Oiso, N; Yoshie, O | 1 |
Fortunato, RS; Kajitani, GS; Menck, CF; Quinet, A; Rocha, CR | 1 |
Bontcheva-Diaz, V; Bouska, JJ; Donawho, CK; Frost, DJ; Fry, EH; Gandhi, VB; Giranda, VL; Gong, J; Grandel, R; Johnson, EF; Klinghofer, V; Liu, X; Lubisch, W; Luo, Y; Marsh, KC; Olson, AM; Park, CH; Penning, TD; Rosenberg, SH; Shi, Y; Thomas, S; Wernet, W; Zhu, GD | 1 |
Colon-Lopez, M; Donawho, C; Ellis, PA; Frost, DJ; Giranda, VL; Kinders, R; LeBlond, D; Lin, CT; Liu, X; Luo, Y; Palma, J; Rodriguez, LE; Saltarelli, M; Shi, Y | 1 |
Burd, R; Limesand, KH; Sittadjody, S; Thangasamy, T | 1 |
Griss, J; Joukhadar, C; Karimian-Teherani, D; Poeppl, W; Rous, W; Skorjanec, S; Soleiman, A; Thallinger, C; Tzaneva, S; Weinlich, G | 1 |
Bontcheva-Diaz, V; Bouska, JJ; Donawho, CK; Frost, DJ; Gandhi, VB; Giranda, VL; Gong, J; Johnson, EF; Klinghofer, V; Liu, X; Luo, Y; Marsh, KC; Olson, AM; Osterling, DJ; Penning, TD; Shi, Y; Zhu, GD | 1 |
Bouska, JJ; Donawho, CK; Ellis, PA; Frost, DJ; Giranda, VL; Johnson, EF; Leverson, J; Liu, X; Luo, Y; Marcotte, PA; Olson, AM; Osterling, DJ; Penning, TD; Przytulinska, M; Rodriguez, LE; Shi, Y; Soni, N; Stavropoulos, J; Thomas, S; Tong, Y | 1 |
Adanja, I; Amighi, K; Debeir, O; Decaestecker, C; Deleuze, P; Hecq, J; Kiss, R; Mathieu, V; Roland, I; Saussez, S; Wauthoz, N | 1 |
Aldrich, W; Triozzi, PL | 1 |
Bontcheva-Diaz, V; Bouska, JJ; Buchanan, FG; Bukofzer, GT; Donawho, CK; Frost, DJ; Fry, EH; Gandhi, VB; Giranda, VL; Gong, J; Johnson, EF; Klinghofer, V; Liu, X; Luo, Y; Marsh, KC; Olson, AM; Osterling, DJ; Park, CH; Penning, TD; Rodriguez, LE; Shi, Y; Thomas, S; Zhu, GD | 1 |
Camaioni, E; Dantzer, F; Dorio, AS; Gold, B; Graziani, G; Leonetti, C; Muzi, A; Pellicciari, R; Scarsella, M; Shah, GM; Tentori, L; Xu, W; Zhang, J | 1 |
Andrade, LN; Chammas, R; de Oliveira, SI; Fernandes, PD; Jancar, S; Nonogaki, S; Onuchic, AC; Pinheiro, MC; Rohde, CB | 1 |
Alitalo, K; Kim, I; Kim, KE; Kim, M; Koh, BI; Koh, GY; Koh, YJ; Nam, DH | 1 |
Di, Y; Gong, J; Guo, JL; He, L; Jin, JL; Lu, YJ; Noteborn, MH; Qu, S; Sun, J; Xia, JJ; Xie, YY; Yin, TJ | 1 |
Caccuri, AM; Cuzzocrea, S; Dorio, AS; Federici, G; Graziani, G; Mazzon, E; Muzi, A; Sau, A; Tentori, L; Vernole, P | 1 |
Chen, J; Huang, Y; Li, Z; Liu, P; Ren, J; Wu, G; Zhang, C; Zhang, R; Zhu, F | 1 |
Chang, Z; Chen, D; Guo, J; Jia, D; Jin, C; Liu, J; Rao, W; Wang, C; Wang, S; Zhang, M | 1 |
Kaneda, Y; Katayama, I; Kiyohara, E; Tamai, K | 1 |
Mateus, C; Robert, C | 1 |
Chakraborty, G; Kumar, S; Kundu, GC; Mishra, R; Patil, TV | 1 |
Apetoh, L; Bruchard, M; Chalmin, F; Ghiringhelli, F; Hervieu, A; Mignot, G; Rébé, C; Vabres, P; Végran, F | 1 |
Becker, JC; Paschen, A; Ugurel, S | 1 |
Becker, JC; Bröcker, EB; Fischer, WH; Kirst, A; Lutz, WK; Wack, C | 1 |
Halaschek-Wiener, J; Jansen, B; Kloog, Y; Wacheck, V | 1 |
Bökönyi, G; Horváth, A; Kéri, G; Szende, B | 1 |
D'Amati, G; Graziani, G; Kalish, V; Leonetti, C; Portarena, I; Scarsella, M; Tentori, L; Vergati, M; Xu, W; Zhang, J; Zupi, G | 1 |
Fei, J; Guo, LH; Lin, GW; Sun, DJ; Wang, JS | 1 |
Alemu, C; Calvin, D; Graziani, G; Hoover, R; Lapidus, R; Leonetti, C; Morgan, L; Scarsella, M; Tang, Z; Tentori, L; Vergati, M; Woznizk, K; Xu, W; Zhang, J | 1 |
Camoutsis, C; Papageorgiou, A; Trafalis, DT | 1 |
Forini, O; Gold, B; Graziani, G; Lacal, PM; Leonetti, C; Li, W; Muzi, A; Ruffini, F; Scarsella, M; Tentori, L; Vergati, M; Zhang, J | 1 |
Abdel-Wahab, OI; Abdel-Wahab, Z; Chu, E; Dewhirst, MW; Friedman, HS; Ko, SH; Pruitt, SK; Tyler, DS; Ueno, T; Yoo, JS; Yoshimoto, Y | 1 |
Bauder-Wüst, U; Eisenhut, M; Eskerski, H; Haberkorn, U; Wolf, M | 1 |
Furuhashi, M; Kawamura, T; Ogawa, Y; Shimada, S; Tsukamoto, K | 1 |
Fujita, K; Hasegawa, K; Inoue, S; Ishihara, K; Ito, S; Wakamatsu, K | 1 |
Newlands, ES; Porteous, JK; Wedge, SR | 1 |
Goodger, S; Kelly, J; Margison, GP; Middleton, MR; Thatcher, N | 1 |
Gadjeva, V; Raikova, E; Zheleva, A | 1 |
Bocsi, J; Hidvégi, M; Lapis, K; Paku, S; Prónai, L; Rásó, E; Szende, B; Tömösközi-Farkas, R | 1 |
Becker, JC; Bröcker, EB; Fischer, WH; Lutz, WK; Wack, C | 1 |
Chen, SH; Liang, YC; Lin, CL; Liu, JD; Tsai, SH | 1 |
Charak, BS; Mazumder, A; Sadowski, RM | 1 |
Gamel, JW; Niederkorn, JY; Sanborn, GE | 1 |
Furukawa, M; Hamada, T; Ishii, M; Kono, T; Taniguchi, S; Tanii, T | 1 |
Aukerman, SL; Biernat, L; Corbett, TH; LoRusso, PM; Polin, L; Redman, BG; Valdivieso, M | 1 |
Baig, G; Chubb, D; Gibson, NW; Goddard, C; Hickman, JA; Langdon, SP; Slack, JA; Stevens, MF; Stone, R; Vickers, L | 1 |
1 review(s) available for dacarbazine and B16 Melanoma
Article | Year |
---|---|
[Anti-CTLA-4 monoclonal antibody: a major step in the treatment of metastatic melanoma].
Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antigens, Neoplasm; Antineoplastic Agents, Alkylating; Autoimmune Diseases; Cancer Vaccines; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Combined Modality Therapy; CTLA-4 Antigen; Dacarbazine; Digestive System Diseases; Drug Screening Assays, Antitumor; Humans; Immunotherapy; Immunotherapy, Active; Ipilimumab; Melanoma; Melanoma, Experimental; Mice; Monitoring, Immunologic; Nervous System Diseases; Vaccines, Subunit | 2011 |
66 other study(ies) available for dacarbazine and B16 Melanoma
Article | Year |
---|---|
Glutathione S-Transferase π-Activatable O
Topics: Animals; Antineoplastic Agents; Azo Compounds; Cell Proliferation; Drug Design; Epithelial Cells; Glutathione S-Transferase pi; Heterografts; Humans; Melanoma, Experimental; Mice; Nitric Oxide; Nitric Oxide Donors | 2018 |
Metformin pretreatment reduces effect to dacarbazine and suppresses melanoma cell resistance.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Antineoplastic Agents, Alkylating; Antioxidants; Cell Line, Tumor; Dacarbazine; Drug Resistance, Neoplasm; Malondialdehyde; Melanoma, Experimental; Metformin; Mice; NF-E2-Related Factor 2; NF-kappa B; Oxidative Stress; Skin Neoplasms; Tumor Suppressor Protein p53 | 2022 |
Dacarbazine alone or associated with melanoma-bearing cancer pain model induces painful hypersensitivity by TRPA1 activation in mice.
Topics: Animals; Antineoplastic Agents, Alkylating; Dacarbazine; HEK293 Cells; Humans; Hyperalgesia; Melanoma, Experimental; Mice; Mice, Inbred C57BL; TRPA1 Cation Channel | 2020 |
Cancer Cell Membrane Camouflaged Mesoporous Silica Nanoparticles Combined with Immune Checkpoint Blockade for Regulating Tumor Microenvironment and Enhancing Antitumor Therapy.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Death; Cell Membrane; Cell Proliferation; Cell Survival; Combined Modality Therapy; Dacarbazine; Humans; Immune Checkpoint Inhibitors; Melanoma, Experimental; Mice, Inbred C57BL; Nanoparticles; Particle Size; Porosity; Silicon Dioxide; Static Electricity; Tumor Microenvironment | 2021 |
In Vitro Effects of Selective COX and LOX Inhibitors and Their Combinations with Antineoplastic Drugs in the Mouse Melanoma Cell Line B16F10.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cells, Cultured; Cyclooxygenase Inhibitors; Dacarbazine; Dose-Response Relationship, Drug; Drug Synergism; Lipoxygenase Inhibitors; Melanoma, Experimental; Mice; Molecular Structure; Temozolomide | 2021 |
Codonopsis pilosula polysaccharide in synergy with dacarbazine inhibits mouse melanoma by repolarizing M2-like tumor-associated macrophages into M1-like tumor-associated macrophages.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Proliferation; Codonopsis; Cytokines; Dacarbazine; Female; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Polysaccharides; Reishi; Tumor Burden; Tumor-Associated Macrophages | 2021 |
TCTP as a therapeutic target in melanoma treatment.
Topics: Animals; Antineoplastic Agents, Alkylating; Biomarkers, Tumor; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Dacarbazine; Female; Gene Expression; Gene Silencing; Humans; Melanoma; Melanoma, Experimental; Mice; Mice, Inbred C57BL; RNA, Messenger; RNA, Small Interfering; Sertraline; Skin Neoplasms; Transfection; Tumor Protein, Translationally-Controlled 1; Tumor Stem Cell Assay; Tumor Suppressor Protein p53 | 2017 |
Cytotoxic antimelanoma drugs suppress the activation of M2 macrophages.
Topics: Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Antineoplastic Agents; B7-H1 Antigen; Dacarbazine; Female; Japan; Lectins, C-Type; Leukocytes, Mononuclear; Macrophages; Mannose Receptor; Mannose-Binding Lectins; Melanoma; Melanoma, Cutaneous Malignant; Melanoma, Experimental; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Monocytes; Nimustine; Receptors, Cell Surface; RNA, Messenger; Skin Neoplasms; Vincristine | 2018 |
Dacarbazine nanoparticle topical delivery system for the treatment of melanoma.
Topics: Administration, Topical; Animals; Antineoplastic Agents, Alkylating; Cell Line, Tumor; Cell Survival; Dacarbazine; Drug Carriers; Drug Delivery Systems; Drug Liberation; Hydrogen-Ion Concentration; Melanoma; Melanoma, Experimental; Mice; Nanoparticles; Particle Size; Permeability; Viscosity | 2017 |
Inflammatory Cytokine Pattern Is Sex-Dependent in Mouse Cutaneous Melanoma Experimental Model.
Topics: Animals; Antineoplastic Agents, Alkylating; Carcinogenesis; Cytokines; Dacarbazine; Disease Models, Animal; Disease Progression; Female; Humans; Inflammation Mediators; Male; Melanoma; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Sex; Skin Neoplasms | 2017 |
Solid Lipid Nanoparticles Carrying Temozolomide for Melanoma Treatment. Preliminary In Vitro and In Vivo Studies.
Topics: Animals; Biomarkers; Cell Line, Tumor; Dacarbazine; Disease Models, Animal; Drug Stability; Female; Humans; Immunohistochemistry; Melanoma; Melanoma, Experimental; Mice; Molecular Structure; Nanoparticles; Neoplastic Stem Cells; Temozolomide | 2018 |
Senescence-associated secretory factors induced by cisplatin in melanoma cells promote non-senescent melanoma cell growth through activation of the ERK1/2-RSK1 pathway.
Topics: A549 Cells; Animals; Antineoplastic Agents; Cell Proliferation; Cellular Senescence; Cisplatin; Cyclin-Dependent Kinase Inhibitor p21; Dacarbazine; Drug Resistance, Neoplasm; HeLa Cells; Humans; Interleukin-1alpha; Melanoma; Melanoma, Experimental; Mice; Mice, Inbred BALB C; Mice, Nude; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Ribosomal Protein S6 Kinases, 90-kDa; Secretory Pathway; Signal Transduction; Skin Neoplasms; Tumor Suppressor Protein p53; Xenograft Model Antitumor Assays | 2018 |
Reversing effect of Lupeol on vasculogenic mimicry in murine melanoma progression.
Topics: AC133 Antigen; Angiogenesis Inhibitors; Animals; Antigens, CD; Antineoplastic Agents, Alkylating; Antineoplastic Agents, Phytogenic; Biological Mimicry; Cadherins; Dacarbazine; Disease Progression; Drug Resistance, Neoplasm; Endothelial Progenitor Cells; Male; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Neoplastic Stem Cells; Neovascularization, Pathologic; Pentacyclic Triterpenes; Phenotype; Platelet Endothelial Cell Adhesion Molecule-1; Tumor Burden | 2019 |
A peptide-modified solid lipid nanoparticle formulation of paclitaxel modulates immunity and outperforms dacarbazine in a murine melanoma model.
Topics: Animals; Antineoplastic Agents, Alkylating; Apoptosis; Calreticulin; CD8-Positive T-Lymphocytes; Cell Line, Tumor; Cytokines; Dacarbazine; Disease Models, Animal; Female; Lung Neoplasms; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Microscopy, Fluorescence; Nanoparticles; Paclitaxel; Peptides; Survival Rate; Tissue Distribution | 2019 |
Combination therapy with dacarbazine and statins improved the survival rate in mice with metastatic melanoma.
Topics: Animals; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Cell Adhesion; Cell Line, Tumor; Cell Proliferation; Dacarbazine; Female; Fluvastatin; Gene Expression Regulation; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lung Neoplasms; Melanoma, Experimental; Mice, Inbred C57BL; Signal Transduction; Simvastatin; Skin Neoplasms; Tumor Burden | 2019 |
Efficacy of oregonin investigated by non-invasive evaluation in a B16 mouse melanoma model.
Topics: Animals; Antineoplastic Agents; Antioxidants; Dacarbazine; Diarylheptanoids; Fluorodeoxyglucose F18; Melanoma, Experimental; Mice; Mice, Inbred BALB C; Mice, Nude; Multimodal Imaging; Neoplasm Transplantation; Neoplasms, Experimental; Plant Extracts; Positron-Emission Tomography; Tomography, X-Ray Computed | 2013 |
Blockade of A2b adenosine receptor reduces tumor growth and immune suppression mediated by myeloid-derived suppressor cells in a mouse model of melanoma.
Topics: Adenosine A2 Receptor Antagonists; Aminopyridines; Animals; Antineoplastic Agents; Cell Line, Tumor; Chemokine CCL2; Dacarbazine; Drug Screening Assays, Antitumor; Drug Synergism; Female; Immunosuppressive Agents; Interleukin-10; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Myeloid Cells; Natural Killer T-Cells; Neoplasm Transplantation; Receptor, Adenosine A2B; Tumor Burden; Tumor Escape; Tumor Microenvironment; Xanthines | 2013 |
Preclinical evaluation of IL2-based immunocytokines supports their use in combination with dacarbazine, paclitaxel and TNF-based immunotherapy.
Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Combined Modality Therapy; Dacarbazine; Drug Synergism; Female; Immunotherapy; Interleukin-2; Melanoma, Experimental; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Paclitaxel; Recombinant Fusion Proteins; Tissue Distribution; Tumor Necrosis Factor-alpha | 2014 |
A human monoclonal antibody targeting the stem cell factor receptor (c-Kit) blocks tumor cell signaling and inhibits tumor growth.
Topics: Animals; Antibodies, Monoclonal; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Cell Proliferation; Cisplatin; Dacarbazine; Etoposide; Female; Heterografts; Humans; Immunoglobulin G; Lung Neoplasms; Melanoma, Experimental; Mice, Nude; Mitogen-Activated Protein Kinase Kinases; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-kit; Signal Transduction; Small Cell Lung Carcinoma | 2014 |
Modulation of radiochemoimmunotherapy-induced B16 melanoma cell death by the pan-caspase inhibitor zVAD-fmk induces anti-tumor immunity in a HMGB1-, nucleotide- and T-cell-dependent manner.
Topics: Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Apyrase; B7-2 Antigen; Caspase Inhibitors; CD8-Positive T-Lymphocytes; Cell Line, Tumor; Chemoradiotherapy; Combined Modality Therapy; Dacarbazine; Dendritic Cells; Histocompatibility Antigens Class II; HMGB1 Protein; Homeodomain Proteins; Hyperthermia, Induced; Interferon-gamma; Lymphocyte Activation; Macrophages, Peritoneal; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Mice, Knockout; Myeloid Differentiation Factor 88; Radiation, Ionizing; Tumor Necrosis Factor-alpha | 2015 |
Antitumor effect of pharmacologic ascorbate in the B16 murine melanoma model.
Topics: Animals; Antineoplastic Agents; Ascorbic Acid; Dacarbazine; DNA Damage; Histones; Humans; Melanoma, Experimental; Mice; Phosphorylation | 2015 |
CCR4 is critically involved in effective antitumor immunity in mice bearing intradermal B16 melanoma.
Topics: Animals; Antineoplastic Agents, Alkylating; Cell Line, Tumor; Cell Proliferation; Chemokine CCL22; Dacarbazine; Dendritic Cells; Genotype; Lymph Nodes; Lymphocytes, Tumor-Infiltrating; Melanoma, Experimental; Mice, Inbred C57BL; Mice, Knockout; Phenotype; Receptors, CCR4; Signal Transduction; Th17 Cells; Time Factors; Transfection; Tumor Burden | 2016 |
NRF2 and glutathione are key resistance mediators to temozolomide in glioma and melanoma cells.
Topics: Animals; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Buthionine Sulfoximine; Cell Line, Tumor; Dacarbazine; Drug Resistance, Neoplasm; Female; Glioma; Glutathione; Humans; Melanoma; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Mice, Nude; NF-E2-Related Factor 2; Temozolomide; Xenograft Model Antitumor Assays | 2016 |
Discovery and SAR of 2-(1-propylpiperidin-4-yl)-1H-benzimidazole-4-carboxamide: A potent inhibitor of poly(ADP-ribose) polymerase (PARP) for the treatment of cancer.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Benzimidazoles; Breast Neoplasms; Cisplatin; Dacarbazine; Enzyme Inhibitors; Humans; Melanoma, Experimental; Mice; Poly(ADP-ribose) Polymerase Inhibitors; Structure-Activity Relationship; Temozolomide; Transplantation, Heterologous; Xenograft Model Antitumor Assays | 2008 |
An enzyme-linked immunosorbent poly(ADP-ribose) polymerase biomarker assay for clinical trials of PARP inhibitors.
Topics: Animals; Antineoplastic Agents; Benzimidazoles; Biomarkers; Clinical Trials as Topic; Dacarbazine; Disease Models, Animal; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Female; Humans; Melanoma, Experimental; Mice; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Temozolomide | 2008 |
Tyrosinase overexpression promotes ATM-dependent p53 phosphorylation by quercetin and sensitizes melanoma cells to dacarbazine.
Topics: Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Antioxidants; Apoptosis; Ataxia Telangiectasia Mutated Proteins; Blotting, Western; Cell Cycle Proteins; Cell Line, Tumor; Dacarbazine; DNA-Binding Proteins; Humans; Melanoma, Experimental; Monophenol Monooxygenase; Phosphorylation; Protein Serine-Threonine Kinases; Quercetin; Reactive Oxygen Species; Transfection; Tumor Suppressor Protein p53; Tumor Suppressor Proteins | 2008 |
Orally administered rapamycin, dacarbazine or both for treatment of human melanoma evaluated in severe combined immunodeficiency mice.
Topics: Administration, Oral; Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Dacarbazine; Dose-Response Relationship, Drug; Female; Humans; Melanoma, Experimental; Mice; Mice, SCID; Random Allocation; Sirolimus; Xenograft Model Antitumor Assays | 2008 |
Discovery of the Poly(ADP-ribose) polymerase (PARP) inhibitor 2-[(R)-2-methylpyrrolidin-2-yl]-1H-benzimidazole-4-carboxamide (ABT-888) for the treatment of cancer.
Topics: Animals; Antineoplastic Agents; Area Under Curve; Benzimidazoles; Biological Availability; Carboplatin; Cyclophosphamide; Dacarbazine; Dogs; Enzyme Inhibitors; Female; Haplorhini; Humans; Magnetic Resonance Spectroscopy; Melanoma, Experimental; Mice; Mice, SCID; Poly(ADP-ribose) Polymerase Inhibitors; Rats; Temozolomide | 2009 |
Synthesis and evaluation of a new generation of orally efficacious benzimidazole-based poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors as anticancer agents.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Benzimidazoles; Biological Availability; Cell Line, Tumor; Dacarbazine; Drug Synergism; Female; Humans; Male; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Neoplasm Transplantation; Oxadiazoles; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerase Inhibitors; Pyridines; Structure-Activity Relationship; Temozolomide; Transplantation, Heterologous | 2009 |
In vivo assessment of temozolomide local delivery for lung cancer inhalation therapy.
Topics: Administration, Inhalation; Animals; Antineoplastic Agents; Cell Line, Tumor; Chromatography, High Pressure Liquid; Dacarbazine; Female; Fluorescent Dyes; Lung Neoplasms; Melanoma, Experimental; Mice; Particle Size; Reproducibility of Results; Temozolomide | 2010 |
Effects of interleukin-1 receptor antagonist and chemotherapy on host-tumor interactions in established melanoma.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Antirheumatic Agents; Blotting, Western; Cell Proliferation; Dacarbazine; Docetaxel; Drug Therapy, Combination; Extracellular Fluid; Female; Flow Cytometry; Immunoenzyme Techniques; Interleukin 1 Receptor Antagonist Protein; Macrophages; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; T-Lymphocytes, Regulatory; Taxoids; Temozolomide; Tumor Cells, Cultured | 2010 |
Optimization of phenyl-substituted benzimidazole carboxamide poly(ADP-ribose) polymerase inhibitors: identification of (S)-2-(2-fluoro-4-(pyrrolidin-2-yl)phenyl)-1H-benzimidazole-4-carboxamide (A-966492), a highly potent and efficacious inhibitor.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Benzimidazoles; Biological Availability; Blood-Brain Barrier; BRCA1 Protein; Carboplatin; Cell Line, Tumor; Crystallography, X-Ray; Dacarbazine; Drug Screening Assays, Antitumor; Female; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Mice, SCID; Models, Molecular; Neoplasm Transplantation; Poly(ADP-ribose) Polymerase Inhibitors; Stereoisomerism; Structure-Activity Relationship; Temozolomide; Transplantation, Heterologous | 2010 |
Pharmacological inhibition of poly(ADP-ribose) polymerase (PARP) activity in PARP-1 silenced tumour cells increases chemosensitivity to temozolomide and to a N3-adenine selective methylating agent.
Topics: Animals; Antineoplastic Agents; Blotting, Western; Cell Division; Cell Line, Tumor; Dacarbazine; Drug Synergism; Enzyme Inhibitors; Flow Cytometry; G2 Phase; HeLa Cells; Humans; Melanoma, Experimental; Methylation; Mice; Netropsin; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Temozolomide | 2010 |
Platelet-activating factor receptor (PAF-R)-dependent pathways control tumour growth and tumour response to chemotherapy.
Topics: Animals; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Azepines; Carcinoma, Ehrlich Tumor; Caspase 3; Cell Proliferation; Cyclooxygenase 2; Dacarbazine; Dinoprostone; Enzyme-Linked Immunosorbent Assay; Female; Flow Cytometry; Galectin 3; Immunohistochemistry; Macrophages; Male; Melanoma, Experimental; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Neovascularization, Pathologic; Nitric Oxide; Phenotype; Platelet Membrane Glycoproteins; Receptors, G-Protein-Coupled; Signal Transduction; Time Factors; Triazoles; Tumor Burden; Vascular Endothelial Growth Factor A | 2010 |
CXCR4 signaling regulates metastasis of chemoresistant melanoma cells by a lymphatic metastatic niche.
Topics: AC133 Antigen; Animals; Antigens, CD; Benzylamines; Cell Movement; Chemokine CXCL12; Cyclams; Dacarbazine; Drug Resistance, Neoplasm; Endothelial Cells; Glycoproteins; Heterocyclic Compounds; Lung Neoplasms; Lymphatic Metastasis; Lymphatic Vessels; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Mice, Transgenic; Peptides; Receptors, CXCR4; Signal Transduction | 2010 |
PTD4-apoptin protein and dacarbazine show a synergistic antitumor effect on B16-F1 melanoma in vitro and in vivo.
Topics: Animals; Antineoplastic Agents, Alkylating; Capsid Proteins; Cell Line; Cell Line, Tumor; Dacarbazine; Drug Synergism; Female; Humans; Melanoma; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Recombinant Fusion Proteins | 2011 |
The glutathione transferase inhibitor 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol (NBDHEX) increases temozolomide efficacy against malignant melanoma.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Cell Proliferation; Dacarbazine; DNA Methylation; Drug Synergism; Glutathione Transferase; Humans; Inhibitory Concentration 50; Male; Melanoma; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Neoplasm Transplantation; Oxadiazoles; Temozolomide | 2011 |
Combinational therapy of interferon-α and chemotherapy normalizes tumor vasculature by regulating pericytes including the novel marker RGS5 in melanoma.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Biomarkers; Blood Vessels; Combined Modality Therapy; Dacarbazine; Down-Regulation; Female; Gene Expression; Interferon-alpha; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Neovascularization, Pathologic; Pericytes; RGS Proteins | 2011 |
Inhibition of B16 murine melanoma metastasis and enhancement of immunity by fever-range whole body hyperthermia.
Topics: Animals; Antineoplastic Agents; Cisplatin; Dacarbazine; Female; Fever; Hyperthermia, Induced; Immunity; Lung Neoplasms; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Neoplasm Metastasis | 2011 |
The combination of chemotherapy with HVJ-E containing Rad51 siRNA elicited diverse anti-tumor effects and synergistically suppressed melanoma.
Topics: Animals; Antigens, Nuclear; Antineoplastic Agents, Alkylating; Dacarbazine; DNA Breaks, Double-Stranded; DNA Repair; DNA-Binding Proteins; Female; Ku Autoantigen; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Rad51 Recombinase; RNA, Small Interfering; Sendai virus; Skin Neoplasms | 2012 |
Semaphorin 3A suppresses tumor growth and metastasis in mice melanoma model.
Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Apoptosis; Blotting, Western; Case-Control Studies; Cell Adhesion; Cell Movement; Cell Proliferation; Cells, Cultured; Curcumin; Dacarbazine; Human Umbilical Vein Endothelial Cells; Humans; Immunoenzyme Techniques; Liver Neoplasms; Lung Neoplasms; Male; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Neovascularization, Pathologic; Phosphorylation; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Semaphorin-3A; Wound Healing | 2012 |
Dacarbazine-mediated upregulation of NKG2D ligands on tumor cells activates NK and CD8 T cells and restrains melanoma growth.
Topics: Animals; Antineoplastic Agents, Alkylating; CD8-Positive T-Lymphocytes; Cell Line, Tumor; Dacarbazine; Disease Models, Animal; Humans; Interferon-gamma; Killer Cells, Natural; Ligands; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Mice, Nude; NK Cell Lectin-Like Receptor Subfamily K; Skin Neoplasms; Up-Regulation | 2013 |
Dacarbazine in melanoma: from a chemotherapeutic drug to an immunomodulating agent.
Topics: Animals; CD8-Positive T-Lymphocytes; Dacarbazine; Humans; Killer Cells, Natural; Melanoma, Experimental; NK Cell Lectin-Like Receptor Subfamily K; Skin Neoplasms | 2013 |
Chemoimmunotherapy for melanoma with dacarbazine and 2,4-dinitrochlorobenzene elicits a specific T cell-dependent immune response.
Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Combined Modality Therapy; Dacarbazine; Dinitrochlorobenzene; Immunotherapy; Irritants; Lung Neoplasms; Lymphocytes, Tumor-Infiltrating; Melanoma; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Neoplasm Metastasis; Neoplasm Transplantation; Ribonucleases; RNA, Messenger; T-Lymphocytes; Time Factors; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 2002 |
Farnesyl thiosalicylic acid chemosensitizes human melanoma in vivo.
Topics: Animals; Antineoplastic Agents; Dacarbazine; Enzyme Inhibitors; Farnesol; Female; Humans; Melanoma, Experimental; Mice; Mice, SCID; Neoplasm Transplantation; ras Proteins; Salicylates; Transplantation, Heterologous; Tumor Cells, Cultured | 2003 |
Effect of a novel somatostatin analogue combined with cytotoxic drugs on human tumour xenografts and metastasis of B16 melanoma.
Topics: Animals; Antineoplastic Agents; Dacarbazine; Disease Models, Animal; Drug Therapy, Combination; Etoposide; Humans; Lymphoma; Male; Melanoma, Experimental; Mice; Mice, Inbred CBA; Neoplasm Metastasis; Neoplasm Transplantation; Neoplasms, Experimental; Peptides, Cyclic; Somatostatin; Xenograft Model Antitumor Assays | 2003 |
Systemic administration of GPI 15427, a novel poly(ADP-ribose) polymerase-1 inhibitor, increases the antitumor activity of temozolomide against intracranial melanoma, glioma, lymphoma.
Topics: Animals; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Drug Synergism; Enzyme Inhibitors; Glioblastoma; Humans; Lymphoma; Male; Melanoma, Experimental; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred DBA; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Survival Rate; Temozolomide; Transplantation, Heterologous; Tumor Cells, Cultured | 2003 |
[Construction of an angiostatin eukaryotic expression vector and characterization of its inhibitory efficiency in B16 melanoma bearing mice].
Topics: Angiostatins; Animals; Antineoplastic Agents, Alkylating; Cell Line, Tumor; Dacarbazine; Genetic Therapy; Genetic Vectors; Melanoma, Experimental; Mice; Mice, Inbred C57BL | 2002 |
Brain distribution and efficacy as chemosensitizer of an oral formulation of PARP-1 inhibitor GPI 15427 in experimental models of CNS tumors.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Area Under Curve; Biological Availability; Blood-Brain Barrier; Brain; Cell Line, Tumor; Central Nervous System Neoplasms; Chromatography, Liquid; Dacarbazine; Disease Models, Animal; Enzyme Inhibitors; Flow Cytometry; G2 Phase; Humans; Inhibitory Concentration 50; Kinetics; Mass Spectrometry; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Neoplasm Transplantation; Organic Chemicals; Poly(ADP-ribose) Polymerases; Rats; Rats, Sprague-Dawley; Temozolomide; Time Factors | 2005 |
Research on the anti-tumour effect of steroid lactam alkylator (NSC-294859) in comparison with conventional chemotherapeutics in malignant melanoma.
Topics: Animals; Antineoplastic Agents, Alkylating; Azasteroids; Cell Line, Tumor; Cisplatin; Dacarbazine; Drug Screening Assays, Antitumor; Esters; Female; Humans; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Neoplasm Transplantation; Nitrogen Mustard Compounds | 2005 |
Poly(ADP-ribose) glycohydrolase inhibitor as chemosensitiser of malignant melanoma for temozolomide.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Dacarbazine; Drug Interactions; Fluorenes; Glycoside Hydrolases; Melanoma; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Neoplasm Transplantation; Skin Neoplasms; Temozolomide | 2005 |
Optimizing a novel regional chemotherapeutic agent against melanoma: hyperthermia-induced enhancement of temozolomide cytotoxicity.
Topics: Animals; Antineoplastic Agents, Alkylating; Apoptosis; Cell Line, Tumor; Chemotherapy, Cancer, Regional Perfusion; Combined Modality Therapy; Cytotoxicity, Immunologic; Dacarbazine; Humans; Hyperthermia, Induced; Immunohistochemistry; Ki-67 Antigen; Melanoma, Experimental; Rats; Temozolomide; Xenograft Model Antitumor Assays | 2006 |
Alkylating benzamides with melanoma cytotoxicity: experimental chemotherapy in a mouse melanoma model.
Topics: Animals; Antineoplastic Agents, Alkylating; Benzamides; Chlorambucil; Dacarbazine; Disease Models, Animal; Humans; Injections, Intraperitoneal; Male; Maximum Tolerated Dose; Melanoma, Experimental; Mice; Mice, Inbred BALB C; Mice, Nude; Skin Neoplasms; Survival Rate; Tumor Cells, Cultured | 2006 |
Improving chemotherapeutic drug penetration in melanoma by imatinib mesylate.
Topics: Animals; Antineoplastic Agents; Benzamides; Biological Transport, Active; Dacarbazine; Female; Imatinib Mesylate; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Piperazines; Protein Kinase Inhibitors; Pyrimidines; Receptor, Platelet-Derived Growth Factor beta | 2008 |
Changes in plasma 5-S-cysteinyldopa concentration in B16 melanoma-bearing mice treated with interferon-beta or dacarbazine.
Topics: Animals; Biomarkers, Tumor; Dacarbazine; Dopamine; Interferon-beta; Melanoma, Experimental; Mice; Mice, Inbred C57BL | 1993 |
Effect of single and multiple administration of an O6-benzylguanine/temozolomide combination: an evaluation in a human melanoma xenograft model.
Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Dacarbazine; Drug Administration Schedule; Guanine; Humans; Melanoma, Experimental; Methyltransferases; Mice; Mice, Nude; Neoplasm Transplantation; O(6)-Methylguanine-DNA Methyltransferase; Temozolomide; Tumor Cells, Cultured | 1997 |
Four-hourly scheduling of temozolomide improves tumour growth delay but not therapeutic index in A375M melanoma xenografts.
Topics: Animals; Antineoplastic Agents, Alkylating; Dacarbazine; Drug Administration Schedule; Guanine; Humans; Male; Melanoma, Experimental; Mice; Mice, Nude; Neoplasm Transplantation; O(6)-Methylguanine-DNA Methyltransferase; Temozolomide; Transplantation, Heterologous | 2000 |
Modulating effect of new potential antimelanomic agents, spin-labeled triazenes and nitrosoureas on the DOPA-oxidase activity of tyrosinase.
Topics: Animals; Antineoplastic Agents, Alkylating; Catalysis; Cyclic N-Oxides; Dacarbazine; Dihydroxyphenylalanine; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Lomustine; Melanoma, Experimental; Mice; Molecular Structure; Monophenol Monooxygenase; Neoplasm Proteins; Nitrosourea Compounds; Oxidation-Reduction; Piperidines; Plant Proteins; Spectrophotometry; Spin Labels; Structure-Activity Relationship; Triazenes; Tumor Cells, Cultured | 1999 |
MSC, a new benzoquinone-containing natural product with antimetastatic effect.
Topics: Animals; Benzoquinones; Colonic Neoplasms; Colorectal Neoplasms; Dacarbazine; Humans; Lectins; Liver Neoplasms; Lung Neoplasms; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Neoplasm Metastasis; Plant Extracts; Transplantation, Heterologous | 1999 |
Chemoimmunotherapy for melanoma with dacarbazine and 2,4-dinitrochlorobenzene: results from a murine tumour model.
Topics: Animals; Antineoplastic Agents, Alkylating; Combined Modality Therapy; Dacarbazine; Dinitrochlorobenzene; Dose-Response Relationship, Drug; Female; Immunotherapy; Irritants; Lung Neoplasms; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Neoplasm Metastasis; Neoplasms, Experimental; Time Factors | 2001 |
Inhibition of melanoma growth and metastasis by combination with (-)-epigallocatechin-3-gallate and dacarbazine in mice.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Catechin; Cell Aggregation; Cell Communication; Cell Movement; Cell Transformation, Neoplastic; Dacarbazine; Drug Screening Assays, Antitumor; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Growth Inhibitors; Injections, Intraperitoneal; Lung Neoplasms; Male; Matrix Metalloproteinases; Melanoma, Experimental; Mice; Neoplasm Transplantation; Phosphorylation; Protein-Tyrosine Kinases; Survival Rate; Tea; Tumor Cells, Cultured; Tumor Stem Cell Assay; Tyrosine | 2001 |
Antitumor effect of interferon plus cyclosporine A following chemotherapy for disseminated melanoma.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Chromium; Cisplatin; Cyclosporine; Dacarbazine; Drug Synergism; Female; Immunotherapy, Adoptive; Interferons; Major Histocompatibility Complex; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Spleen; T-Lymphocytes, Regulatory | 1992 |
Efficacy of dacarbazine (DTIC) in preventing metastases arising from intraocular melanomas in mice.
Topics: Animals; Anterior Eye Segment; Dacarbazine; Eye Enucleation; Eye Neoplasms; Female; Lung Neoplasms; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Survival Rate; Time Factors; Verapamil | 1992 |
Altered response to dacarbazine by murine melanoma cells cultured in type I collagen gel.
Topics: Animals; Cell Division; Collagen; Dacarbazine; Gels; Melanoma, Experimental; Mice; Tretinoin; Tumor Cells, Cultured | 1990 |
Antitumor efficacy of interleukin-2 alone and in combination with adriamycin and dacarbazine in murine solid tumor systems.
Topics: Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Dacarbazine; Doxorubicin; Female; Interleukin-2; Male; Mammary Neoplasms, Experimental; Melanoma, Experimental; Mice; Mice, Inbred Strains; Neoplasms, Experimental | 1990 |
Antitumor activity and pharmacokinetics in mice of 8-carbamoyl-3-methyl-imidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one (CCRG 81045; M & B 39831), a novel drug with potential as an alternative to dacarbazine.
Topics: Animals; Antineoplastic Agents; Dacarbazine; Imidazoles; Lung Neoplasms; Male; Melanoma, Experimental; Mice; Mice, Inbred BALB C; Mice, Inbred CBA; Mice, Inbred DBA; Mice, Inbred Strains; Neoplasms, Experimental; Plasmacytoma; Sarcoma, Experimental; Species Specificity; Temozolomide | 1987 |