d-ala(2)-mephe(4)-met(0)-ol-enkephalin and Obesity

d-ala(2)-mephe(4)-met(0)-ol-enkephalin has been researched along with Obesity* in 1 studies

Other Studies

1 other study(ies) available for d-ala(2)-mephe(4)-met(0)-ol-enkephalin and Obesity

Article	Year
The effect of enkephalin analogue on pituitary hormone release in human obesity. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 1987, Volume: 19, Issue:2 To elucidate further the role of opioid systems in the neuroendocrine alterations associated with obesity, we investigated the effect of the synthetic enkephalin analogue DAMME in 11 obese subjects and 10 lean controls. Prolactin responses to DAMME were similar in lean and obese, even in those obese subjects who had absent prolactin responses to insulin-induced hypoglycaemia. The obese showed impaired growth hormone release after both DAMME and insulin-induced hypoglycaemia compared to the lean subjects. The discordance of prolactin responses to DAMME and insulin-induced hypoglycaemia in the obese suggests that altered opioid systems are unlikely to account for the hypothalamic dysfunction present in obesity. Topics: Adult; Blood Glucose; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Female; Growth Hormone; Humans; Insulin; Male; Obesity; Pituitary Gland; Prolactin; Thyrotropin-Releasing Hormone	1987

Article

Year

The effect of enkephalin analogue on pituitary hormone release in human obesity.

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 1987, Volume: 19, Issue:2

To elucidate further the role of opioid systems in the neuroendocrine alterations associated with obesity, we investigated the effect of the synthetic enkephalin analogue DAMME in 11 obese subjects and 10 lean controls. Prolactin responses to DAMME were similar in lean and obese, even in those obese subjects who had absent prolactin responses to insulin-induced hypoglycaemia. The obese showed impaired growth hormone release after both DAMME and insulin-induced hypoglycaemia compared to the lean subjects. The discordance of prolactin responses to DAMME and insulin-induced hypoglycaemia in the obese suggests that altered opioid systems are unlikely to account for the hypothalamic dysfunction present in obesity.

Topics: Adult; Blood Glucose; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Female; Growth Hormone; Humans; Insulin; Male; Obesity; Pituitary Gland; Prolactin; Thyrotropin-Releasing Hormone

1987