d-609 and Neoplasms

d-609 has been researched along with Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for d-609 and Neoplasms

ArticleYear
Antitumoral activity of a xanthate compound. I. Cytotoxicity studies with neoplastic cell lines in vitro.
    Cancer letters, 1989, Jul-15, Volume: 46, Issue:2

    Xanthate derivatives were shown previously to display antitumor activity against transformed fibroblasts and lymphoma cells in combination with monocarboxylic acids [1]. Various malignant cell lines of human origin were treated in vitro to explore the range of antitumoral activity of the compounds. The combination of tricyclodecan-9-yl-xanthogenate (D 609) with undecanoic acid (C11) exerted dose dependent cytotoxic and antiproliferative effects on cell lines both from solid tumors (glioblastomas, colon-carcinomas) and hematological diseases (lymphomas, CML/BC). Additionally, the combination of D 609/C11 was able to kill both methotrexate- and adriamycin-resistant L 1210 and S 180 cells, indicating that there is no cross-resistance for these drugs and D 609/C11 in vitro.

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bridged-Ring Compounds; Drug Resistance; Fatty Acids; Humans; Neoplasms; Norbornanes; Thiocarbamates; Thiones; Tumor Cells, Cultured

1989