d-609 has been researched along with Adenocarcinoma* in 1 studies
1 other study(ies) available for d-609 and Adenocarcinoma
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The concerted regulation of cPLA2, COX2, and lipocortin 1 expression by IL-1beta in A549 cells.
The pro-inflammatory effects of IL-1beta have been linked to the induction of the enzyme COX-2. We now show that in addition to increasing the expression of COX-2, IL-1beta concomittantly decreased the expression of lipocortin 1 on the surface of A549 cells. Furthermore, cytosolic PLA2 is concomittantly activated by phosphorylation-resulting in a stimulation of arachidonic acid and PGE2 release. All of these effects appear to be mediated via a common pathway of PLC and PKC activation. Activation of cPLA2 is inhibited by dexamethasone in a lipocortin 1-dependent mechanism. We present a novel hypothesis whereby the effects of IL-1beta are not only due to activation of enzymes necessary for generation of eicosanoids but also to an inhibition of mechanisms that regulate the supply of arachidonic acid. Topics: Adenocarcinoma; Annexin A1; Antibodies, Monoclonal; Arachidonic Acid; Blotting, Western; Bridged-Ring Compounds; Cell Line; Cytosol; Dexamethasone; Enzyme Activation; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Humans; Interleukin-1; Lung Neoplasms; Norbornanes; Phospholipases A; Phospholipases A2; Prostaglandin-Endoperoxide Synthases; Protein Kinase C; Thiocarbamates; Thiones; Tumor Cells, Cultured; Type C Phospholipases | 1996 |