Page last updated: 2024-10-17

cytosine and Papilloma

cytosine has been researched along with Papilloma in 82 studies

Papilloma: A circumscribed benign epithelial tumor projecting from the surrounding surface; more precisely, a benign epithelial neoplasm consisting of villous or arborescent outgrowths of fibrovascular stroma covered by neoplastic cells. (Stedman, 25th ed)

Research Excerpts

ExcerptRelevanceReference
"We report the history of an 8-year-old girl who was treated for suspected lung lesions of respiratory papillomatosis with Indole-3-Carbinol, local and intravenous injections of Cidofovir for 27 months."7.73Successful use of intralesional and intravenous cidofovir in association with indole-3-carbinol in an 8-year-old girl with pulmonary papillomatosis. ( Bodart, E; de Bilderling, G; De Clercq, E; Lawson, G; Naesens, L; Remacle, M; Snoeck, R; Tuerlinckx, D, 2005)
"Respiratory papillomatosis is a rare and often severe disease, usually localized in the larynx."5.30Treatment of severe laryngeal papillomatosis with intralesional injections of cidofovir [(S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine]. ( De Clercq, E; Desloovere, C; Feenstra, L; Naesens, L; Snoeck, R; Van Ranst, M; Wellens, W, 1998)
"We report the history of an 8-year-old girl who was treated for suspected lung lesions of respiratory papillomatosis with Indole-3-Carbinol, local and intravenous injections of Cidofovir for 27 months."3.73Successful use of intralesional and intravenous cidofovir in association with indole-3-carbinol in an 8-year-old girl with pulmonary papillomatosis. ( Bodart, E; de Bilderling, G; De Clercq, E; Lawson, G; Naesens, L; Remacle, M; Snoeck, R; Tuerlinckx, D, 2005)
" However, questions remain regarding the optimal dosing schedule and side-effect profile."2.723.5-Year follow-up of intralesional cidofovir protocol for pediatric recurrent respiratory papillomatosis. ( Akst, LM; Chung, BJ; Koltai, PJ, 2006)
"Laryngeal papillomatosis is characterised by multiple papillomata affecting the upper respiratory tract."1.37Novel method of intralesional cidofovir injection into laryngotracheal papillomata. ( Al-Shukri, J; Moir, AA; Sahota, RS; Uddin, FJ, 2011)
"Respiratory papillomatosis affects the larynx in most cases."1.37Adjuvant therapy for laryngeal papillomatosis. ( Bahar, MS; Boltežar, IH; Gale, N; Matičič, M; Poljak, M; Zargi, M, 2011)
"Papillomas were harvested from two patients pre- and post-cidofovir treatment."1.35Cidofovir modulated gene expression in recurrent respiratory papillomatosis. ( Kerschner, JE; Patel, NJ; Poetker, DM, 2008)
"Recurrent laryngeal papillomatosis is caused by the human papilloma virus and characterized by multiple exophytic lesions of the vocal tract; it is a benign disease, but one that tends to recur after removal of growths."1.35Cidofovir injection for recurrent laryngeal papillomatosis. ( Lee, JC; Lin, YS; Shi, ZP; Wang, CH, 2008)
"Recurrent laryngeal papillomatosis is a benign disease of the larynx often leading to organic and functional restrictions."1.34Intralesional Cidofovir application in recurrent laryngeal papillomatosis. ( Bloching, M; Neumann, K; Pudszuhn, A; Welzel, C, 2007)
"The two other patients showed recurrences, but at a lower rate than previously."1.33Treatment of recurrent respiratory papillomatosis with microsurgery in combination with intralesional cidofovir--a prospective study. ( Dikkers, FG, 2006)
" Complete cures were obtained using 1% (w/v) topical cidofovir at dosing schedules of twice daily for 8 weeks beginning at 4 weeks after CRPV infection, which represents a time when papillomas were clearly visible."1.31In vivo anti-papillomavirus activity of nucleoside analogues including cidofovir on CRPV-induced rabbit papillomas. ( Budgeon, LR; Christensen, ND; Kreider, JW; Pickel, MD, 2000)
"Respiratory papillomatosis is a rare and often severe disease, usually localized in the larynx."1.30Treatment of severe laryngeal papillomatosis with intralesional injections of cidofovir [(S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine]. ( De Clercq, E; Desloovere, C; Feenstra, L; Naesens, L; Snoeck, R; Van Ranst, M; Wellens, W, 1998)

Research

Studies (82)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's6 (7.32)18.2507
2000's61 (74.39)29.6817
2010's15 (18.29)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Orssaud, C1
Wermert, D1
Roux, A1
Laccourreye, O1
Sors, H1
Roche, O1
Dufier, JL1
Ahmed, MM1
Connor, MP1
Palazzolo, M1
Thompson, ME1
Lospinoso, J1
O'Connor, P1
Howard, NS1
Maturo, SC1
Poetker, DM1
Patel, NJ1
Kerschner, JE2
Capaccio, P1
Ottaviani, F1
Cuccarini, V1
Corbellino, M1
Parravicini, C1
Menzo, S1
Schindler, A1
Pignataro, L1
McMurray, JS1
Connor, N1
Ford, CN1
Bielecki, I1
Mniszek, J1
Cofała, M1
Derkay, C1
Carvalho, CM1
Huot, L1
Charlois, AL1
Khalfallah, SA1
Chapuis, F1
Froehlich, P5
Lott, DG1
Krakovitz, PR1
Verguts, MM1
Genbrugge, E1
de Jong, FI1
Donne, AJ2
Hampson, L1
He, XT1
Day, PJ1
Salway, F1
Rothera, MP2
Homer, JJ2
Hampson, IN1
Carney, AS1
Evans, AS1
Mirza, S1
Psaltis, A1
Preuss, SF1
Quante, G1
Sajan, JA1
Merati, AL1
Osipov, V1
Szabo, S1
Blumin, JH2
Chadha, NK3
James, A2
Gupta, HT1
Robinson, RA2
Murray, RC1
Karnell, LH1
Smith, RJ3
Hoffman, HT2
Man, LX1
Statham, MM1
Rosen, CA3
Donne, A1
Rothera, M1
Homer, J1
Sahota, RS1
Uddin, FJ1
Al-Shukri, J1
Moir, AA1
Tjon Pian Gi, RE1
Dietz, A1
Djukic, V1
Eckel, HE1
Friedrich, G1
Golusinski, W1
Hantzakos, A1
Lawson, G2
Remacle, M2
Rihkanen, H1
Dikkers, FG3
Boltežar, IH1
Bahar, MS1
Zargi, M1
Gale, N1
Matičič, M1
Poljak, M1
Ablanedo-Terrazas, Y1
Soda-Merhy, A1
Hernández-Palestina, M1
Ormsby, CE1
Reyes-Terán, G1
Cavel, O1
Ayari, S3
Coulombeau, B3
Bielamowicz, S1
Villagomez, V1
Stager, SV1
Wilson, WR2
El Hakim, H1
Waddell, AN1
Crysdale, WS1
Milczuk, HA1
Akst, LM2
Lee, W1
Discolo, C1
Knott, D1
Younes, A1
Koltai, PJ2
Pransky, SM3
Albright, JT1
Magit, AE3
Chhetri, DK2
Shapiro, NL2
Neumann, K2
Pudszuhn, A2
Welzel, C2
Bartel-Friedrich, S1
Passmann, M1
Naiman, AN3
Ceruse, P1
Peyton Shirley, W1
Wiatrak, B1
Kendall, KA1
Schraff, S1
Derkay, CS1
Burke, B1
Lawson, L1
Mandell, DL1
Arjmand, EM1
Kay, DJ1
Casselbrant, ML1
Silverman, DA1
Pitman, MJ1
Co, J1
Woo, P1
Lee, AS1
de Bilderling, G1
Bodart, E1
Tuerlinckx, D1
Naesens, L2
De Clercq, E4
Snoeck, R4
Cullen, RD1
Zdanski, C1
Palomar Asenjo, V1
Palomar García, V1
Soteras Ollé, J1
Ruiz Giner, A1
Shehab, N1
Sweet, BV1
Hogikyan, ND1
Getz, AE1
Scharf, J1
Amin, MR1
Huber, K1
Sadick, H1
Götte, K1
Lee, JH2
Inglis, AF1
Wemer, RD1
Tasca, RA1
McCormick, M1
Clarke, RW1
Seymour, CW1
Krimsky, WS1
Sager, J1
Kruklitis, RJ1
Lund, ME1
Musani, AI1
Sterman, DH1
Abedipour, D1
Fresnel, E1
Bour, JB1
Pontes, P1
Avelino, M1
Pignatari, S1
Weckx, LL1
Shemen, LJ1
Shnayder, Y1
Sheahan, P1
Sexton, S1
Russell, JD1
Chung, BJ1
Giles, BL1
Seifert, B1
Nicollas, R1
Landry, G1
Colombeau, B1
Bloching, M1
James, AL1
Bitar, M1
Baz, R1
Fuleihan, N1
Muallem, M1
Soma, MA1
Albert, DM1
Lindsay, F1
Bloom, D1
Pransky, S1
Stabley, R1
Shick, P1
Shi, ZP1
Wang, CH1
Lee, JC1
Lin, YS1
Loyo, M1
Pai, SI1
Netto, GJ1
Tunkel, DE1
Broekema, FI1
Tanna, N1
Sidell, D1
Joshi, AS1
Bielamowicz, SA1
Sutter, C1
Greenhalgh, DA1
Ueda, M1
Abhyankar, S1
Ngai, P1
Hennings, H1
Schweizer, J1
Yuspa, SH1
Strickland, JE1
Peng, X1
Lang, CM1
Kreider, JW2
Van Cutsem, E1
Van Ranst, M2
Fiten, P1
Opdenakker, G1
Geboes, K1
Janssens, J1
Rutgeerts, P1
Vantrappen, G1
Wellens, W2
Desloovere, C1
Feenstra, L2
Petersen, BL1
Buchwald, C1
Gerstoft, J1
Bretlau, P1
Lindeberg, H1
Kearns, DB2
Kang, DR1
Duncan, NO1
Hashemiyoon, R1
Hawrych, A1
Brewster, DF1
Dancey, DR1
Chamberlain, DW1
Krajden, M1
Palefsky, J1
Alberti, PW1
Downey, GP1
Christensen, ND1
Pickel, MD1
Budgeon, LR1
Van Valckenborgh, I1
De Boeck, K1
Armbruster, C2
Kreuzer, A1
Vorbach, H1
Huber, M1
Auborn, KJ1
Berke, GS1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
"Use of Cidofovir Injection in the Treatment of Recurrent Respiratory Papillomatosis."[NCT00205374]Phase 419 participants (Actual)Interventional1999-11-30Completed
A Pilot Study to Evaluate the Effects of Antiangiogenic Factor as an Adjunct Treatment After Photoangiolysis in Patients With Bilateral Recurrent Respiratory Papillomatosis of the Vocal Fold[NCT01020747]Phase 120 participants (Actual)Interventional2009-11-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

12-month Change in Voice Handicap Index (VHI) Score

"Voice Handicap Index. This scale rates a patient's perception of voice related handicap in the domains of functional, physical, and emotional. There are 10 questions for each domain. Each question is rated by the subject on a 5-point scale, never =0, almost never =1, sometimes =2, almost always =3, always =4). A lower total score or domain score indicates improved, or less, voice handicap. Thus, the maximum total score is 4 X 30 = 120. For each domain, the maximum score is 4 X 10 = 40. Scores of 0 are the lowest possible score. In the paper we say that the Maximum score is 100, but obviously is it actually 120. Complete scale = 0-120.~Lower score indicates improved perceived voice-realted quality of life." (NCT00205374)
Timeframe: 2 months, and 12 months

,
Interventionscores on a scale (Mean)
2 months12 months
Cidofovir2231
Placebo3242

Change in Papilloma Severity

"Derkay Severity Score. Minimum Score is Zero. Maximum score is 86. Treatment of RRP with cidofovir injection will be considered efficacious if drug group patients experience clinically or statistically significant changes in papilloma severity and inter-surgery time intervals (relative to pre-treatment assessments), when compared with placebo group patients.~The scale rates - Voice (normal 0, abnormal 1, aphonic 2) Stridor (absent 0, present with activity 1, present at rest 2) Urgency of the intervention (scheduled 0, elective 1, urgent 2, emergent 3) Respiratory distress (none 0, mild 1, mod 2, severe 3, extreme 4).~For multiple anatomical sites (18 or more) in the upper airway, left and right sides, lesions are rated as 0=none, 1=surface lesion, 2=raised lesion, and 3=bulky lesion).~A higher rating value indicates more advanced disease and a worse outcome." (NCT00205374)
Timeframe: Baseline, 2 months, and 12 months

,
Interventionscores on a scale (Mean)
Baseline2 months12 months
Cidofovir13.23.72.7
Placebo123.65.1

The Primary Activity Variable Was the Recurrence of Recurrent Respiratory Papillomatosis (RRP) in Bevacizumab Treated and the Un-treated Vocal Fold in the Same Patient During and at the End of the 6-month Treatment Period.

Prior to each treatment,the area of reappearance of disease was measured and the % change from baseline was calculated. The change was then added to the % change from the previous treatment to generate a cumulative total % change of reappearance of RRP from baseline. The additive nature of this parameter resulted in % greater than 100% if the area of vocal fold affected by the RRP increased over the baseline measurement. (NCT01020747)
Timeframe: 6 months

Interventiontotal percentage change (Mean)
Bevacizumab Treated Vocal Fold85.3
Untreated Vocal Fold225.3

Reviews

15 reviews available for cytosine and Papilloma

ArticleYear
Adjuvant antiviral therapy for recurrent respiratory papillomatosis.
    The Cochrane database of systematic reviews, 2010, Jan-20, Issue:1

    Topics: Adolescent; Adult; Airway Obstruction; Antiviral Agents; Chemotherapy, Adjuvant; Child; Cidofovir; C

2010
Adjuvant antiviral therapy for recurrent respiratory papillomatosis.
    The Cochrane database of systematic reviews, 2012, Dec-12, Volume: 12

    Topics: Adolescent; Adult; Airway Obstruction; Antiviral Agents; Chemotherapy, Adjuvant; Child; Cidofovir; C

2012
Observations on the early results of treatment of recurrent respiratory papillomatosis using cidofovir.
    The Journal of otolaryngology, 2002, Volume: 31, Issue:6

    Topics: Antineoplastic Agents; Child, Preschool; Cidofovir; Cytosine; Female; Glottis; Humans; Injections, I

2002
Current diagnostic and management trends for recurrent respiratory papillomatosis.
    Current opinion in otolaryngology & head and neck surgery, 2004, Volume: 12, Issue:6

    Topics: Antineoplastic Agents; Antiviral Agents; Cidofovir; Cytosine; Humans; Neoplasm Recurrence, Local; Or

2004
Cidofovir for the treatment of recurrent respiratory papillomatosis: a review of the literature.
    Pharmacotherapy, 2005, Volume: 25, Issue:7

    Topics: Adult; Antineoplastic Agents; Child; Cidofovir; Clinical Trials as Topic; Cytosine; Dose-Response Re

2005
[Current therapeutic options for recurrent respiratory papillomatosis].
    HNO, 2005, Volume: 53, Issue:11

    Topics: Adult; Chemotherapy, Adjuvant; Child; Cidofovir; Cytosine; Drug Combinations; Follow-Up Studies; Hum

2005
Recurrent respiratory papillomatosis: pathogenesis to treatment.
    Current opinion in otolaryngology & head and neck surgery, 2005, Volume: 13, Issue:6

    Topics: Antineoplastic Agents; Chemotherapy, Adjuvant; Cidofovir; Cytosine; Human papillomavirus 11; Human p

2005
Transbronchial needle injection: a systematic review of a new diagnostic and therapeutic paradigm.
    Respiration; international review of thoracic diseases, 2006, Volume: 73, Issue:1

    Topics: Bronchoscopy; Catheterization; Cidofovir; Cytosine; Equipment Design; Humans; Injections; Lung Disea

2006
Antiviral agents for the treatment of recurrent respiratory papillomatosis: a systematic review of the English-language literature.
    Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 2007, Volume: 136, Issue:6

    Topics: Antiviral Agents; Cidofovir; Cytosine; Humans; Injections, Intralesional; Neoplasm Recurrence, Local

2007
Can zinc be an adjuvant therapy for juvenile onset recurrent respiratory papillomatosis?
    International journal of pediatric otorhinolaryngology, 2007, Volume: 71, Issue:8

    Topics: Adolescent; Antiviral Agents; Chemotherapy, Adjuvant; Child, Preschool; Cidofovir; Cytosine; Drug Th

2007
Cidofovir: to use or not to use?
    Current opinion in otolaryngology & head and neck surgery, 2008, Volume: 16, Issue:1

    Topics: Antineoplastic Agents; Antiviral Agents; Cidofovir; Cytosine; Humans; Injections, Intralesional; Neo

2008
Side-effects of cidofovir in the treatment of recurrent respiratory papillomatosis.
    European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2008, Volume: 265, Issue:8

    Topics: Adolescent; Adult; Animals; Antineoplastic Agents; Child; Cidofovir; Cytosine; Female; Humans; Injec

2008
Scientific and clinical aspects of the use of cidofovir in recurrent respiratory papillomatosis.
    International journal of pediatric otorhinolaryngology, 2008, Volume: 72, Issue:7

    Topics: Antiviral Agents; Cidofovir; Cytosine; Humans; Neoplasm Recurrence, Local; Organophosphonates; Papil

2008
Successful treatment of juvenile laryngeal papillomatosis-related multicystic lung disease with cidofovir: case report and review of the literature.
    Chest, 2000, Volume: 118, Issue:4

    Topics: Adult; Antiviral Agents; Biopsy; Cidofovir; Cystic Adenomatoid Malformation of Lung, Congenital; Cyt

2000
Therapy for recurrent respiratory papillomatosis.
    Antiviral therapy, 2002, Volume: 7, Issue:1

    Topics: Cidofovir; Cytosine; Humans; Interferons; Laryngeal Neoplasms; Lung Neoplasms; Neoplasm Recurrence,

2002

Trials

8 trials available for cytosine and Papilloma

ArticleYear
Cidofovir efficacy in recurrent respiratory papillomatosis: a randomized, double-blind, placebo-controlled study.
    The Annals of otology, rhinology, and laryngology, 2008, Volume: 117, Issue:7

    Topics: Adolescent; Adult; Antineoplastic Agents; Antiviral Agents; Child; Child, Preschool; Cidofovir; Cyto

2008
Intralesional cidofovir therapy for laryngeal papilloma in an adult cohort.
    The Laryngoscope, 2002, Volume: 112, Issue:4

    Topics: Antiviral Agents; Cidofovir; Cohort Studies; Cytosine; Drug Administration Schedule; Female; Humans;

2002
A scheduled protocol for the treatment of juvenile recurrent respiratory papillomatosis with intralesional cidofovir.
    Archives of otolaryngology--head & neck surgery, 2003, Volume: 129, Issue:10

    Topics: Antineoplastic Agents; Antineoplastic Protocols; Child; Child, Preschool; Cidofovir; Cytosine; Drug

2003
Is cidofovir a useful adjunctive therapy for recurrent respiratory papillomatosis in children?
    International journal of pediatric otorhinolaryngology, 2004, Volume: 68, Issue:4

    Topics: Antineoplastic Agents; Chemotherapy, Adjuvant; Child, Preschool; Cidofovir; Cytosine; Debridement; F

2004
3.5-Year follow-up of intralesional cidofovir protocol for pediatric recurrent respiratory papillomatosis.
    International journal of pediatric otorhinolaryngology, 2006, Volume: 70, Issue:11

    Topics: Adolescent; Antineoplastic Agents; Antineoplastic Protocols; Child; Child, Preschool; Cidofovir; Cyt

2006
Intermediate-term and long-term results after treatment by cidofovir and excision in juvenile laryngeal papillomatosis.
    The Annals of otology, rhinology, and laryngology, 2006, Volume: 115, Issue:9

    Topics: Adolescent; Adult; Antiviral Agents; Child; Child, Preschool; Cidofovir; Combined Modality Therapy;

2006
Intralesional cidofovir for recurrent laryngeal papillomas: preliminary report.
    Ear, nose, & throat journal, 2000, Volume: 79, Issue:4

    Topics: Adult; Antiviral Agents; Cidofovir; Clinical Protocols; Cytosine; Humans; Injections, Intralesional;

2000
Clinical update on 10 children treated with intralesional cidofovir injections for severe recurrent respiratory papillomatosis.
    Archives of otolaryngology--head & neck surgery, 2000, Volume: 126, Issue:10

    Topics: Antiviral Agents; Child; Child, Preschool; Cidofovir; Cytosine; Female; Humans; Injections, Intrales

2000

Other Studies

59 other studies available for cytosine and Papilloma

ArticleYear
Urrets-Zavalia syndrome as a complication of ocular hypotonia due to intravenous cidofovir treatment.
    Eye (London, England), 2014, Volume: 28, Issue:6

    Topics: Aged; Antiviral Agents; Cidofovir; Cytosine; Female; Humans; Infusions, Intravenous; Laryngeal Neopl

2014
Effect of high-dose vocal fold injection of cidofovir and bevacizumab in a porcine model.
    The Laryngoscope, 2017, Volume: 127, Issue:3

    Topics: Animals; Bevacizumab; Biopsy, Needle; Cidofovir; Cytosine; Disease Models, Animal; Dose-Response Rel

2017
Cidofovir modulated gene expression in recurrent respiratory papillomatosis.
    International journal of pediatric otorhinolaryngology, 2008, Volume: 72, Issue:9

    Topics: Antiviral Agents; Cidofovir; Cytosine; Down-Regulation; Gene Expression; Humans; Interferon Regulato

2008
Surgery and topic cidofovir for nasal squamous papillomatosis in HIV+ patient.
    European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2009, Volume: 266, Issue:6

    Topics: Administration, Topical; Antineoplastic Agents; Cidofovir; Combined Modality Therapy; Cytosine; Endo

2009
Intralesional injection of cidofovir for recurrent respiratory papillomatosis in children.
    International journal of pediatric otorhinolaryngology, 2009, Volume: 73, Issue:5

    Topics: Adolescent; Antiviral Agents; Child; Child, Preschool; Cidofovir; Cytosine; Female; Humans; Infant;

2009
Use of cidofovir for treatment of recurrent respiratory papillomatosis.
    Archives of otolaryngology--head & neck surgery, 2009, Volume: 135, Issue:2

    Topics: Animals; Antiviral Agents; Cidofovir; Cytosine; Humans; Organophosphonates; Papilloma; Recurrence; R

2009
Prognostic factors of recurrent respiratory papillomatosis from a registry of 72 patients.
    Acta oto-laryngologica, 2009, Volume: 129, Issue:4

    Topics: Adult; Antineoplastic Agents; Child; Child, Preschool; Cidofovir; Cytosine; Databases, Factual; Fema

2009
Squamous cell carcinoma associated with intralesional injection of cidofovir for recurrent respiratory papillomatosis.
    The Laryngoscope, 2009, Volume: 119, Issue:3

    Topics: Antineoplastic Agents; Carcinoma, Squamous Cell; Child; Cidofovir; Cytosine; Female; Follow-Up Studi

2009
Treatment results in adult-onset recurrent respiratory papillomatosis.
    B-ENT, 2009, Volume: 5, Issue:3

    Topics: Adolescent; Adult; Age of Onset; Aged; Aged, 80 and over; Antineoplastic Agents; Chemotherapy, Adjuv

2009
Potential risk factors associated with the use of cidofovir to treat benign human papillomavirus-related disease.
    Antiviral therapy, 2009, Volume: 14, Issue:7

    Topics: Antiviral Agents; Cell Line; Cell Survival; Cidofovir; Cytosine; Gene Expression Profiling; Gene Exp

2009
Radiofrequency coblation for treatment of advanced laryngotracheal recurrent respiratory papillomatosis.
    The Journal of laryngology and otology, 2010, Volume: 124, Issue:5

    Topics: Adult; Antineoplastic Agents; Catheter Ablation; Cidofovir; Combined Modality Therapy; Cytosine; End

2010
In reference to Squamous cell carcinoma associated with intralesional injection of cidofovir for recurrent respiratory papillomatosis.
    The Laryngoscope, 2010, Volume: 120, Issue:3

    Topics: Antineoplastic Agents; Carcinoma, Squamous Cell; Cidofovir; Cytosine; Humans; Injections, Intralesio

2010
Prevalence of dysplasia in juvenile-onset recurrent respiratory papillomatosis.
    Archives of otolaryngology--head & neck surgery, 2010, Volume: 136, Issue:1

    Topics: Adolescent; Antineoplastic Agents; Chi-Square Distribution; Child; Child, Preschool; Cidofovir; Cyto

2010
Degrees of dysplasia and the use of cidofovir in patients with recurrent respiratory papillomatosis.
    The Laryngoscope, 2010, Volume: 120, Issue:4

    Topics: Adult; Aged; Biopsy; Cidofovir; Cytosine; Disease Progression; Female; Follow-Up Studies; Humans; Ma

2010
Mucosal bridge and pitting of the true vocal fold: an unusual complication of cidofovir injection.
    The Annals of otology, rhinology, and laryngology, 2010, Volume: 119, Issue:4

    Topics: Adult; Antiviral Agents; Cidofovir; Cytosine; Humans; Injections, Intralesional; Laryngeal Neoplasms

2010
Should intralesional cidofovir be used for recurrent respiratory papillomatosis?
    Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery, 2010, Volume: 35, Issue:1

    Topics: Antiviral Agents; Cidofovir; Cytosine; Humans; Infusions, Intralesional; Organophosphonates; Papillo

2010
Novel method of intralesional cidofovir injection into laryngotracheal papillomata.
    The Journal of laryngology and otology, 2011, Volume: 125, Issue:4

    Topics: Antiviral Agents; Bronchoscopy; Cidofovir; Cytosine; Female; Humans; Injections, Intralesional; Lary

2011
Treatment of recurrent respiratory papillomatosis and adverse reactions following off-label use of cidofovir (Vistide®).
    European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2012, Volume: 269, Issue:2

    Topics: Adverse Drug Reaction Reporting Systems; Antiviral Agents; Cidofovir; Cytosine; Injections, Intrales

2012
Adjuvant therapy for laryngeal papillomatosis.
    Acta dermatovenerologica Alpina, Pannonica, et Adriatica, 2011, Volume: 20, Issue:3

    Topics: Acyclovir; Adolescent; Adult; Aged; Aged, 80 and over; Anticarcinogenic Agents; Antiviral Agents; Ch

2011
Intralesional cidofovir in severe juvenile respiratory papillomatosis.
    B-ENT, 2012, Volume: 8, Issue:3

    Topics: Antineoplastic Agents; Child; Child, Preschool; Cidofovir; Cytosine; Dose-Response Relationship, Dru

2012
Minimizing surgical management through the use of adjuvant medical therapies.
    The Laryngoscope, 2012, Volume: 122 Suppl 4

    Topics: Antiviral Agents; Chemotherapy, Adjuvant; Child; Cidofovir; Cytosine; Humans; Laryngeal Neoplasms; O

2012
Intralesional cidofovir for the treatment of severe juvenile recurrent respiratory papillomatosis: long-term results in 4 children.
    Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 2003, Volume: 128, Issue:6

    Topics: Antiviral Agents; Child; Child, Preschool; Cidofovir; Cytosine; Female; Humans; Infant; Injections,

2003
Stepped-dose protocol of cidofovir therapy in recurrent respiratory papillomatosis in children.
    Archives of otolaryngology--head & neck surgery, 2003, Volume: 129, Issue:8

    Topics: Adolescent; Antineoplastic Agents; Child; Child, Preschool; Cidofovir; Combined Modality Therapy; Cy

2003
Long-term follow-up of pediatric recurrent respiratory papillomatosis managed with intralesional cidofovir.
    The Laryngoscope, 2003, Volume: 113, Issue:9

    Topics: Airway Obstruction; Antiviral Agents; Chemotherapy, Adjuvant; Child; Child, Preschool; Cidofovir; Co

2003
[Intralesional cidofovir injections for recurrent laryngeal papillomatosis: first results].
    Laryngo- rhino- otologie, 2003, Volume: 82, Issue:10

    Topics: Adolescent; Adult; Aged; Airway Obstruction; Antiviral Agents; Chemotherapy, Adjuvant; Child; Child,

2003
Intralesional cidofovir and surgical excision for laryngeal papillomatosis.
    The Laryngoscope, 2003, Volume: 113, Issue:12

    Topics: Adolescent; Adult; Antiviral Agents; Child; Child, Preschool; Cidofovir; Combined Modality Therapy;

2003
Current treatment for laryngeal papillomatosis.
    Current opinion in otolaryngology & head and neck surgery, 2004, Volume: 12, Issue:3

    Topics: Adult; Antineoplastic Agents; Antiviral Agents; Child; Child, Preschool; Cidofovir; Combined Modalit

2004
American Society of Pediatric Otolaryngology members' experience with recurrent respiratory papillomatosis and the use of adjuvant therapy.
    Archives of otolaryngology--head & neck surgery, 2004, Volume: 130, Issue:9

    Topics: Antineoplastic Agents; Antiviral Agents; Australia; Chemotherapy, Adjuvant; Child; Child, Preschool;

2004
Intralesional cidofovir for pediatric recurrent respiratory papillomatosis.
    Archives of otolaryngology--head & neck surgery, 2004, Volume: 130, Issue:11

    Topics: Antineoplastic Agents; Child; Child, Preschool; Cidofovir; Cytosine; Debridement; Female; Humans; In

2004
Serial office-based intralesional injection of cidofovir in adult-onset recurrent respiratory papillomatosis.
    The Annals of otology, rhinology, and laryngology, 2004, Volume: 113, Issue:11

    Topics: Adult; Ambulatory Care; Antineoplastic Agents; Cidofovir; Cytosine; Female; Humans; Injections, Intr

2004
Efficacy of cidofovir injection for the treatment of recurrent respiratory papillomatosis.
    Journal of voice : official journal of the Voice Foundation, 2004, Volume: 18, Issue:4

    Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Child; Cidofovir; Cytosine; Female; Humans; Injectio

2004
Successful use of intralesional and intravenous cidofovir in association with indole-3-carbinol in an 8-year-old girl with pulmonary papillomatosis.
    Journal of medical virology, 2005, Volume: 75, Issue:2

    Topics: Antiviral Agents; Chemotherapy, Adjuvant; Child; Cidofovir; Cytosine; Drug Therapy, Combination; Fem

2005
Delivery of cidofovir to respiratory papillomas of the distal trachea.
    The Laryngoscope, 2005, Volume: 115, Issue:3

    Topics: Antineoplastic Agents; Bronchoscopes; Child, Preschool; Cidofovir; Cytosine; Humans; Neoplasm Recurr

2005
[Cidofovir activity in infantile recurrent respiratory papillomatosis].
    Acta otorrinolaringologica espanola, 2005, Volume: 56, Issue:1

    Topics: Antiviral Agents; Child, Preschool; Cidofovir; Combined Modality Therapy; Cytosine; Humans; Laryngea

2005
Thyrohyoid approach to cidofovir injection: a case study.
    Journal of voice : official journal of the Voice Foundation, 2005, Volume: 19, Issue:3

    Topics: Antineoplastic Agents; Cidofovir; Cytosine; Humans; Injections, Intralesional; Laryngeal Neoplasms;

2005
Treatment of recurrent respiratory papillomatosis with microsurgery in combination with intralesional cidofovir--a prospective study.
    European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2006, Volume: 263, Issue:5

    Topics: Antineoplastic Agents; Cidofovir; Combined Modality Therapy; Cytosine; Female; Humans; Injections, I

2006
Cidofovir and the black box warning.
    The Annals of otology, rhinology, and laryngology, 2005, Volume: 114, Issue:11

    Topics: Animals; Antineoplastic Agents; Cidofovir; Cytosine; Disease Progression; Drug Labeling; Humans; Lar

2005
Case of progressive dysplasia concomitant with intralesional cidofovir administration for recurrent respiratory papillomatosis.
    The Annals of otology, rhinology, and laryngology, 2005, Volume: 114, Issue:11

    Topics: Adult; Antineoplastic Agents; Cidofovir; Cytosine; Disease Progression; Female; Humans; Injections,

2005
British Association of Paediatric Otorhinolaryngology members experience with recurrent respiratory papillomatosis.
    International journal of pediatric otorhinolaryngology, 2006, Volume: 70, Issue:7

    Topics: Anticarcinogenic Agents; Antiviral Agents; Child; Cidofovir; Cytosine; Databases, Factual; Health Ca

2006
Natural history of adult-onset laryngeal papillomatosis following multiple cidofovir injections.
    The Annals of otology, rhinology, and laryngology, 2006, Volume: 115, Issue:3

    Topics: Adult; Antiviral Agents; Biopsy; Cidofovir; Cytosine; DNA, Viral; Female; Follow-Up Studies; Human p

2006
Effect of local application of cidofovir on the control of recurrences in recurrent laryngeal papillomatosis.
    Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 2006, Volume: 135, Issue:1

    Topics: Adult; Antineoplastic Agents; Cidofovir; Cytosine; Follow-Up Studies; Humans; Injections, Intralesio

2006
Office-based intralesional cidofovir injections for nasal septal papilloma: a pilot study.
    Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 2006, Volume: 135, Issue:1

    Topics: Adult; Antineoplastic Agents; Cidofovir; Cytosine; Follow-Up Studies; Humans; Injections, Intralesio

2006
Is intralesional cidofovir worthwhile in juvenile recurrent respiratory papillomatosis?
    The Journal of laryngology and otology, 2006, Volume: 120, Issue:7

    Topics: Adjuvants, Pharmaceutic; Adolescent; Antineoplastic Agents; Child; Child, Preschool; Cidofovir; Comb

2006
CR12/339--Nebulized cidofovir for recurrent respiratory papillomatosis: a case report.
    Paediatric respiratory reviews, 2006, Volume: 7 Suppl 1

    Topics: Administration, Inhalation; Antineoplastic Agents; Cidofovir; Cytosine; Female; Follow-Up Studies; H

2006
Intralesional Cidofovir application in recurrent laryngeal papillomatosis.
    European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2007, Volume: 264, Issue:1

    Topics: Adult; Aged; Antiviral Agents; Child, Preschool; Cidofovir; Combined Modality Therapy; Cytosine; Fem

2007
Histologic review of cidofovir-treated recurrent respiratory papillomatosis.
    The Annals of otology, rhinology, and laryngology, 2008, Volume: 117, Issue:2

    Topics: Antineoplastic Agents; Child; Cidofovir; Cytosine; Humans; Laryngeal Neoplasms; Neoplasm Recurrence,

2008
Cidofovir injection for recurrent laryngeal papillomatosis.
    Journal of the Chinese Medical Association : JCMA, 2008, Volume: 71, Issue:3

    Topics: Adult; Antineoplastic Agents; Child; Cidofovir; Cytosine; Female; Humans; Injections; Laryngeal Neop

2008
Aggressive recurrent respiratory papillomatosis in a neonate.
    International journal of pediatric otorhinolaryngology, 2008, Volume: 72, Issue:6

    Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Cetuximab; Cidofov

2008
Adult intralesional cidofovir therapy for laryngeal papilloma: a 10-year perspective.
    Archives of otolaryngology--head & neck surgery, 2008, Volume: 134, Issue:5

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Cidofovir; Cytosine; Female; Huma

2008
SENCAR mouse skin tumors produced by promotion alone have A to G mutations in codon 61 of the c-rasHa gene.
    Carcinogenesis, 1994, Volume: 15, Issue:9

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Adenine; Animals; Base Sequence; Cocarcinogenesis; Codon; Cytosine

1994
Methylation of cottontail rabbit papillomavirus DNA and tissue-specific expression in transgenic rabbits.
    Virus research, 1995, Volume: 35, Issue:1

    Topics: 5-Methylcytosine; Animals; Animals, Genetically Modified; Cottontail rabbit papillomavirus; Cytosine

1995
Successful treatment of a squamous papilloma of the hypopharynx-esophagus by local injections of (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine.
    Journal of medical virology, 1995, Volume: 45, Issue:2

    Topics: Aged; Antiviral Agents; Cidofovir; Cytosine; Esophageal Neoplasms; Female; Humans; Hypopharyngeal Ne

1995
Treatment of severe laryngeal papillomatosis with intralesional injections of cidofovir [(S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine].
    Journal of medical virology, 1998, Volume: 54, Issue:3

    Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Antiviral Agents; Child; Cidofovir; Combined Modalit

1998
An aggressive and invasive growth of juvenile papillomas involving the total respiratory tract.
    The Journal of laryngology and otology, 1998, Volume: 112, Issue:11

    Topics: Adult; Antiviral Agents; Cidofovir; Combined Modality Therapy; Cytosine; DNA, Viral; Fatal Outcome;

1998
Intralesional cidofovir for recurrent respiratory papillomatosis in children.
    Archives of otolaryngology--head & neck surgery, 1999, Volume: 125, Issue:10

    Topics: Antiviral Agents; Child, Preschool; Cidofovir; Cytosine; Female; Humans; Infant; Injections, Intrale

1999
In vivo anti-papillomavirus activity of nucleoside analogues including cidofovir on CRPV-induced rabbit papillomas.
    Antiviral research, 2000, Volume: 48, Issue:2

    Topics: Animals; Antiviral Agents; Cidofovir; Cottontail rabbit papillomavirus; Cytosine; Disease Models, An

2000
Systemic cidofovir in papillomatosis.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2001, Feb-01, Volume: 32, Issue:3

    Topics: Antiviral Agents; Child; Cidofovir; Cytosine; Female; Humans; Neoplasm Invasiveness; Neoplasm Recurr

2001
Successful treatment of severe respiratory papillomatosis with intravenous cidofovir and interferon alpha-2b.
    The European respiratory journal, 2001, Volume: 17, Issue:4

    Topics: Adult; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cidofovir; Cytosine; F

2001
Office-based treatment of laryngeal papillomatosis with percutaneous injection of cidofovir.
    Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 2002, Volume: 126, Issue:6

    Topics: Adult; Ambulatory Care; Antineoplastic Agents; Cidofovir; Cytosine; Female; Follow-Up Studies; Human

2002