cytosine has been researched along with Melanoma in 26 studies
Melanoma: A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The total levels of DNA 5-methylcytosine were determined in a series of related highly metastatic cell lines which had been isolated from the poorly metastatic human melanoma tumor line MeWo." | 7.67 | Reduced levels of DNA 5-methylcytosine in metastatic variants of the human melanoma cell line MeWo. ( Kerbel, RS; Liteplo, RG, 1987) |
| "Because benign nevic cells may also form 'deposits' in lymph nodes (nodal nevus), the pathological evaluation for metastatic melanoma within sentinel lymph nodes can be challenging." | 5.42 | 5-Hydroxymethylcytosine expression in metastatic melanoma versus nodal nevus in sentinel lymph node biopsies. ( Granter, SR; Guo, W; Laga, AC; Lee, JJ; Lian, CG; Murphy, GF; Saavedra, AP; Xu, S; Zhan, Q, 2015) |
| "Mutations in sunlight-induced melanoma arise from cyclobutane pyrimidine dimers (CPDs), DNA photoproducts that are typically created picoseconds after an ultraviolet (UV) photon is absorbed at thymine or cytosine." | 3.81 | Photochemistry. Chemiexcitation of melanin derivatives induces DNA photoproducts long after UV exposure. ( Bacchiocchi, A; Bechara, EJ; Brash, DE; Douki, T; Halaban, R; Mano, CM; Premi, S; Wakamatsu, K; Wallisch, S; Weiner, AB, 2015) |
| "The total levels of DNA 5-methylcytosine were determined in a series of related highly metastatic cell lines which had been isolated from the poorly metastatic human melanoma tumor line MeWo." | 3.67 | Reduced levels of DNA 5-methylcytosine in metastatic variants of the human melanoma cell line MeWo. ( Kerbel, RS; Liteplo, RG, 1987) |
| "Melanoma is an aggressive neoplasm with increasing incidence that is classified by the NCI as a recalcitrant cancer, i." | 1.51 | Thymine DNA glycosylase as a novel target for melanoma. ( Beeharry, N; Bellacosa, A; Bhattacharjee, V; Cosentino, L; Davidson, G; Davidson, I; Devarajan, K; Dorjsuren, DG; Einarson, M; Giordano, A; Jelinek, J; Kadariya, Y; Katz, RA; Larue, L; Mancuso, P; Nicolas, E; Simeonov, A; Sobol, RW; Sun, H; Testa, JR; Tricarico, R; Yen, TJ, 2019) |
| "Because benign nevic cells may also form 'deposits' in lymph nodes (nodal nevus), the pathological evaluation for metastatic melanoma within sentinel lymph nodes can be challenging." | 1.42 | 5-Hydroxymethylcytosine expression in metastatic melanoma versus nodal nevus in sentinel lymph node biopsies. ( Granter, SR; Guo, W; Laga, AC; Lee, JJ; Lian, CG; Murphy, GF; Saavedra, AP; Xu, S; Zhan, Q, 2015) |
| "melanoma is 92." | 1.42 | Diagnostic utility of 5-hydroxymethylcytosine immunohistochemistry in melanocytic proliferations. ( Burns, KH; Rodić, N; Sharma, R; Taube, JM; Zampella, J, 2015) |
| "Mucosal melanomas have genetic alterations distinct from those in cutaneous melanomas." | 1.35 | Esophageal melanomas harbor frequent NRAS mutations unlike melanomas of other mucosal sites. ( Kanai, Y; Kouda, S; Nakanishi, Y; Ogawa, R; Sekine, S, 2009) |
| "Malignant melanoma, an aggressive skin cancer, is accessible to non-invasive IR radiation based surface probes for its identification and grading." | 1.35 | Distinction of malignant melanoma and epidermis using IR micro-spectroscopy and statistical methods. ( Argov, S; Cagnano, E; Hammody, Z; Mordechai, S; Moreh, R; Sahu, RK, 2008) |
| " The best therapeutic response was observed when pyrimidinone was given every 4 days for a total of 7 injections; however, other schedules and dosing frequencies also gave significant responses." | 1.27 | Chemoimmunotherapy of B 16 melanoma and P388 leukemia with cyclophosphamide and pyrimidinones. ( Johnson, MA; Li, LH; Moeller, RB; Wallace, TL, 1984) |
| " Pharmacologic studies demonstrated a significant decrease in the bioavailability of the drug as it was administered in this study." | 1.27 | Phase I study of 2-amino-5-bromo-6-phenyl-4(3H)-pyrimidinone (ABPP), an oral interferon inducer, in cancer patients. ( Fitzpatrick, FA; Gutknecht, GD; Hersh, EM; Reele, SB; Rios, A; Stringfellow, DA, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (30.77) | 18.7374 |
| 1990's | 1 (3.85) | 18.2507 |
| 2000's | 4 (15.38) | 29.6817 |
| 2010's | 11 (42.31) | 24.3611 |
| 2020's | 2 (7.69) | 2.80 |
| Authors | Studies |
|---|---|
| Carrier, A | 1 |
| Desjobert, C | 1 |
| Ponger, L | 1 |
| Lamant, L | 1 |
| Bustos, M | 1 |
| Torres-Ferreira, J | 1 |
| Henrique, R | 1 |
| Jeronimo, C | 1 |
| Lanfrancone, L | 1 |
| Delmas, A | 1 |
| Favre, G | 1 |
| Daunay, A | 1 |
| Busato, F | 1 |
| Hoon, DSB | 1 |
| Tost, J | 1 |
| Etievant, C | 1 |
| Riond, J | 1 |
| Arimondo, PB | 1 |
| Jin, SG | 1 |
| Pettinga, D | 1 |
| Johnson, J | 1 |
| Li, P | 1 |
| Pfeifer, GP | 1 |
| Mancuso, P | 1 |
| Tricarico, R | 1 |
| Bhattacharjee, V | 1 |
| Cosentino, L | 1 |
| Kadariya, Y | 1 |
| Jelinek, J | 1 |
| Nicolas, E | 1 |
| Einarson, M | 1 |
| Beeharry, N | 1 |
| Devarajan, K | 1 |
| Katz, RA | 1 |
| Dorjsuren, DG | 1 |
| Sun, H | 1 |
| Simeonov, A | 1 |
| Giordano, A | 1 |
| Testa, JR | 1 |
| Davidson, G | 1 |
| Davidson, I | 1 |
| Larue, L | 1 |
| Sobol, RW | 1 |
| Yen, TJ | 1 |
| Bellacosa, A | 1 |
| Sugiyama, T | 1 |
| Chen, Y | 1 |
| Gambichler, T | 1 |
| Sand, M | 1 |
| Skrygan, M | 1 |
| Uchiyama, R | 1 |
| Uhara, H | 1 |
| Uchiyama, A | 1 |
| Ogawa, E | 1 |
| Takazawa, Y | 1 |
| Ashida, A | 1 |
| Koga, H | 1 |
| Hayashi, K | 1 |
| Kiniwa, Y | 1 |
| Okuyama, R | 1 |
| Larson, AR | 1 |
| Dresser, KA | 1 |
| Zhan, Q | 4 |
| Lezcano, C | 2 |
| Woda, BA | 2 |
| Yosufi, B | 1 |
| Thompson, JF | 2 |
| Scolyer, RA | 2 |
| Mihm, MC | 3 |
| Shi, YG | 2 |
| Murphy, GF | 4 |
| Lian, CG | 4 |
| Lee, JJ | 2 |
| Granter, SR | 1 |
| Laga, AC | 1 |
| Saavedra, AP | 1 |
| Guo, W | 1 |
| Xu, S | 2 |
| Premi, S | 1 |
| Wallisch, S | 1 |
| Mano, CM | 1 |
| Weiner, AB | 1 |
| Bacchiocchi, A | 1 |
| Wakamatsu, K | 1 |
| Bechara, EJ | 1 |
| Halaban, R | 1 |
| Douki, T | 1 |
| Brash, DE | 1 |
| Rodić, N | 1 |
| Zampella, J | 1 |
| Sharma, R | 1 |
| Burns, KH | 1 |
| Taube, JM | 1 |
| Cook, M | 1 |
| Wang, TJ | 1 |
| Sekine, S | 1 |
| Nakanishi, Y | 1 |
| Ogawa, R | 1 |
| Kouda, S | 1 |
| Kanai, Y | 1 |
| Franke, JC | 1 |
| Plötz, M | 1 |
| Prokop, A | 1 |
| Geilen, CC | 1 |
| Schmalz, HG | 1 |
| Eberle, J | 1 |
| Xu, Y | 1 |
| Ceol, C | 1 |
| Wu, F | 1 |
| Larson, A | 1 |
| Dresser, K | 1 |
| Xu, W | 1 |
| Tan, L | 1 |
| Hu, Y | 1 |
| Lee, CW | 1 |
| Hu, D | 1 |
| Lian, BQ | 1 |
| Kleffel, S | 1 |
| Yang, Y | 1 |
| Neiswender, J | 1 |
| Khorasani, AJ | 1 |
| Fang, R | 1 |
| Duncan, LM | 1 |
| Kakavand, H | 1 |
| Houvras, Y | 1 |
| Zon, LI | 1 |
| Kaiser, UB | 1 |
| Schatton, T | 1 |
| Calista, D | 1 |
| Raulin, J | 1 |
| Hammody, Z | 1 |
| Argov, S | 1 |
| Sahu, RK | 1 |
| Cagnano, E | 1 |
| Moreh, R | 1 |
| Mordechai, S | 1 |
| Stringfellow, DA | 2 |
| Li, LH | 2 |
| Johnson, MA | 1 |
| Moeller, RB | 1 |
| Wallace, TL | 2 |
| Siu, LL | 1 |
| Attardo, G | 1 |
| Izbicka, E | 1 |
| Lawrence, R | 1 |
| Cerna, C | 1 |
| Gomez, L | 1 |
| Davidson, K | 1 |
| Finkle, C | 1 |
| Marsolais, C | 1 |
| Rowinsky, EK | 1 |
| Von Hoff, DD | 1 |
| Ormerod, EJ | 1 |
| Everett, CA | 1 |
| Finch, M | 1 |
| Hart, IR | 1 |
| Rios, A | 1 |
| Fitzpatrick, FA | 1 |
| Reele, SB | 1 |
| Gutknecht, GD | 1 |
| Hersh, EM | 1 |
| Liteplo, RG | 1 |
| Kerbel, RS | 1 |
| Richard, KA | 1 |
| Tracey, DE | 1 |
| Kappler, JW | 1 |
| Fedorov, NA | 1 |
| Matveenko, VN | 1 |
| Tikhonova, EF | 1 |
1 review available for cytosine and Melanoma
| Article | Year |
|---|---|
Development in lipid drugs.
Topics: Animals; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Cidofovir; Cowpox virus; Cytosine; | 2005 |
25 other studies available for cytosine and Melanoma
| Article | Year |
|---|---|
DNA methylome combined with chromosome cluster-oriented analysis provides an early signature for cutaneous melanoma aggressiveness.
Topics: Animals; Chromosomes; CpG Islands; Cytosine; DNA Methylation; Epigenesis, Genetic; Epigenome; Gene E | 2022 |
The major mechanism of melanoma mutations is based on deamination of cytosine in pyrimidine dimers as determined by circle damage sequencing.
Topics: Cytosine; Deamination; DNA Damage; Humans; Melanoma; Mutation; Pyrimidine Dimers; Ultraviolet Rays | 2021 |
Thymine DNA glycosylase as a novel target for melanoma.
Topics: Animals; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cytosine; DNA Methylation; Enzyme Inhibit | 2019 |
Biochemical reconstitution of UV-induced mutational processes.
Topics: 5-Methylcytosine; Cell-Free System; Cytosine; Deamination; DNA Damage; DNA Replication; DNA-Cytosine | 2019 |
Loss of 5-hydroxymethylcytosine and ten-eleven translocation 2 protein expression in malignant melanoma.
Topics: 5-Methylcytosine; Biomarkers, Tumor; Cytosine; Dioxygenases; Disease Progression; DNA-Binding Protei | 2013 |
5-Hydroxymethylcytosine as a useful marker to differentiate between malignant melanomas and benign melanocytic nevi.
Topics: 5-Methylcytosine; Adult; Aged; Aged, 80 and over; Biomarkers; CpG Islands; Cytosine; DNA Methylation | 2014 |
Loss of 5-hydroxymethylcytosine correlates with increasing morphologic dysplasia in melanocytic tumors.
Topics: 5-Methylcytosine; Adult; Aged; Aged, 80 and over; Cytosine; DNA Methylation; Female; Humans; Male; M | 2014 |
5-Hydroxymethylcytosine expression in metastatic melanoma versus nodal nevus in sentinel lymph node biopsies.
Topics: 5-Methylcytosine; Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Cytosine; Female; Fluorescent A | 2015 |
Photochemistry. Chemiexcitation of melanin derivatives induces DNA photoproducts long after UV exposure.
Topics: Animals; Cells, Cultured; Cytosine; DNA; DNA Damage; Energy Transfer; Humans; Melanins; Melanocytes; | 2015 |
Diagnostic utility of 5-hydroxymethylcytosine immunohistochemistry in melanocytic proliferations.
Topics: 5-Methylcytosine; Cytosine; Diagnosis, Differential; Humans; Immunohistochemistry; Lymph Nodes; Lymp | 2015 |
Loss of the epigenetic mark, 5-Hydroxymethylcytosine, correlates with small cell/nevoid subpopulations and assists in microstaging of human melanoma.
Topics: 5-Methylcytosine; Adolescent; Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Carcinoma, Small Ce | 2015 |
Esophageal melanomas harbor frequent NRAS mutations unlike melanomas of other mucosal sites.
Topics: Aged; Cytosine; DNA Mutational Analysis; DNA, Neoplasm; Esophageal Neoplasms; Female; Guanine; Human | 2009 |
New caspase-independent but ROS-dependent apoptosis pathways are targeted in melanoma cells by an iron-containing cytosine analogue.
Topics: Apoptosis; Caspases; Cell Line, Tumor; Cytosine; Drug Delivery Systems; Ferrous Compounds; Humans; M | 2010 |
Loss of 5-hydroxymethylcytosine is an epigenetic hallmark of melanoma.
Topics: 5-Methylcytosine; Cytosine; Dioxygenases; DNA-Binding Proteins; Epigenesis, Genetic; Gene Expression | 2012 |
Regression of a cutaneous melanoma metastasis after intralesional cidofovir.
Topics: Antineoplastic Agents; Cidofovir; Cytosine; Humans; Lymphatic Metastasis; Male; Melanoma; Middle Age | 2003 |
Distinction of malignant melanoma and epidermis using IR micro-spectroscopy and statistical methods.
Topics: Biomarkers, Tumor; Cytosine; Discriminant Analysis; DNA, Neoplasm; Epidermis; Guanine; Humans; Melan | 2008 |
Antineoplastic properties of pyrimidinone interferon inducers.
Topics: Animals; Cytosine; Female; Immunity; Interferon Inducers; Interferons; Melanoma; Mice; Mice, Inbred | 1980 |
Chemoimmunotherapy of B 16 melanoma and P388 leukemia with cyclophosphamide and pyrimidinones.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cell Line; Combined | 1984 |
Activity of (-)-2'-deoxy-3'-oxacytidine (BCH-4556) against human tumor colony-forming units.
Topics: Antineoplastic Agents; Cytosine; Dioxolanes; Female; Humans; Kidney Neoplasms; Melanoma; Ovarian Neo | 1998 |
DNA methylation levels in human and murine melanoma cell lines of varying metastatic potential.
Topics: 5-Methylcytosine; Animals; Azacitidine; Cell Line; Cytosine; DNA, Neoplasm; Humans; Melanoma; Methyl | 1986 |
Phase I study of 2-amino-5-bromo-6-phenyl-4(3H)-pyrimidinone (ABPP), an oral interferon inducer, in cancer patients.
Topics: Adult; Aged; Cytosine; Drug Evaluation; Humans; Interferon Inducers; Interferons; Male; Melanoma; Mi | 1986 |
Reduced levels of DNA 5-methylcytosine in metastatic variants of the human melanoma cell line MeWo.
Topics: 5-Methylcytosine; Animals; Cell Line; Chromatography, High Pressure Liquid; Cytosine; DNA; Humans; H | 1987 |
Mechanism of antitumor action of pyrimidinones in the treatment of B16 melanoma and P388 leukemia.
Topics: Animals; Antibodies; Cell Division; Cyclophosphamide; Cytosine; G(M1) Ganglioside; Glycosphingolipid | 1985 |
The 5-methylcytosine content of DNA: tissue specificity.
Topics: Adrenal Gland Neoplasms; Animals; Carbon Isotopes; Cell Line; Chick Embryo; Clone Cells; Culture Tec | 1971 |
[Utilization of pyrimidine precursors in the tumor and liver of mice with Ehrlich ascites carcinoma].
Topics: Animals; Carbon Isotopes; Carcinoma, Ehrlich Tumor; Cytosine; DNA; DNA, Neoplasm; Liver; Male; Melan | 1970 |