Page last updated: 2024-10-17

cytosine and Leukemia

cytosine has been researched along with Leukemia in 38 studies

Leukemia: A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)

Research Excerpts

ExcerptRelevanceReference
"To investigate the activity of a novel dioxolane L-nucleoside analog, troxacitabine (L-(-)-OddC, BCH-4556), in patients with refractory leukemia."9.10Phase II study of troxacitabine, a novel dioxolane nucleoside analog, in patients with refractory leukemia. ( Andreeff, M; Baker, SD; Bivins, C; Cortes, JE; Garcia-Manero, G; Giles, FJ; Jolivet, J; Kantarjian, HM; Miller, CB; O'Brien, SM; Thomas, DA, 2002)
"To investigate the toxicity profile, activity, and pharmacokinetics of a novel L-nucleoside analog, troxacitabine (BCH-4556), in patients with advanced leukemia."9.09Troxacitabine, a novel dioxolane nucleoside analog, has activity in patients with advanced leukemia. ( Baker, SD; Beran, M; Bivins, C; Cortes, JE; Giles, FJ; Jolivet, J; Kantarjian, HM; O'Brien, S; Smith, TL; Thomas, DA, 2001)
" Future studies will be needed to address modified dosing according to emerging pharmacokinetic and pharmacodynamic data and combination therapy which may lead to improved clinical benefit for troxacitabine in hematologic malignancies."6.73A phase II multicenter study of troxacitabine in relapsed or refractory lymphoproliferative neoplasms or multiple myeloma. ( Baccarani, M; Belanger, R; Ben-Yehuda, D; Caballero, D; Coiffier, B; Facon, T; Fanin, R; Giles, F; Gregory, SA; Panwalkar, A; Vose, JM, 2007)
"To investigate the activity of a novel dioxolane L-nucleoside analog, troxacitabine (L-(-)-OddC, BCH-4556), in patients with refractory leukemia."5.10Phase II study of troxacitabine, a novel dioxolane nucleoside analog, in patients with refractory leukemia. ( Andreeff, M; Baker, SD; Bivins, C; Cortes, JE; Garcia-Manero, G; Giles, FJ; Jolivet, J; Kantarjian, HM; Miller, CB; O'Brien, SM; Thomas, DA, 2002)
"To investigate the toxicity profile, activity, and pharmacokinetics of a novel L-nucleoside analog, troxacitabine (BCH-4556), in patients with advanced leukemia."5.09Troxacitabine, a novel dioxolane nucleoside analog, has activity in patients with advanced leukemia. ( Baker, SD; Beran, M; Bivins, C; Cortes, JE; Giles, FJ; Jolivet, J; Kantarjian, HM; O'Brien, S; Smith, TL; Thomas, DA, 2001)
"Cloretazine [1,2-bis(methylsulfonyl)-1-(2-chloroethyl)-2-[(methylamino)carbonyl]hydrazine; VNP40101M; 101M] is a relatively new prodrug with activity in elderly acute myelogenous leukemia (AML) patients."3.74Lethality to leukemia cell lines of DNA interstrand cross-links generated by Cloretazine derived alkylating species. ( Baumann, RP; Ishiguro, K; Penketh, PG; Sartorelli, AC; Seow, HA; Shyam, K, 2008)
" Troxacitabine is an anti-leukemic agent which can be associated with palmar-plantar erythrodysesthesia syndrome (PPES)."3.71Chemotherapy-induced palmar-plantar erythrodysesthesia syndrome--recall following different chemotherapy agents. ( Cortes, JE; Giles, FJ; Hui, YF, 2002)
"The inner cytosine methylation was analyzed in the CCWGG sequences of the 5'-terminal region of the human calcitonin gene from peripheral blood and bone marrow cells in various forms of leukemia."3.70[The lack of the CpNpG methylation at the 5'-terminal region of the human calcitonin gene in norm and in leukemia []. ( Bur'ianov, IaI; D'iachenko, OV; Marinich, DV; Shevchuk, TV; Vorob'ev, IA; Zakharchenko, NS, 2000)
"We have studied the overall 5-methylcytosine content and the percentage of methylated CpG-dinucleotides in 25 cases of untreated human acute leukemias."3.67DNA methylation levels in acute human leukemia. ( Boehm, TL; Drahovsky, D; Pfeifer, GP; Steigerwald, S, 1988)
"The degree of 5-methylcytosine formation in DNA sequences differing in reassociation rate and susceptibility to DNase II digestion has been investigated in human chronic myelogenic leukemia and acute leukemia leukocytes, human PHA-stimulated lymphocytes and murine L5178Y lymphoblasts cultured in various phases of growth."3.66Intragenomic distribution of 5-methylcytosine in various forms of human and murine leukemic cells. ( Kornacka, L; Malec, J; Sawecka, J, 1980)
" Future studies will be needed to address modified dosing according to emerging pharmacokinetic and pharmacodynamic data and combination therapy which may lead to improved clinical benefit for troxacitabine in hematologic malignancies."2.73A phase II multicenter study of troxacitabine in relapsed or refractory lymphoproliferative neoplasms or multiple myeloma. ( Baccarani, M; Belanger, R; Ben-Yehuda, D; Caballero, D; Coiffier, B; Facon, T; Fanin, R; Giles, F; Gregory, SA; Panwalkar, A; Vose, JM, 2007)
"The leukemias are complex diseases with a wide range of clinical, morphologic, biologic, molecular, and clinical features and a consequent array of possible responses to any given intervention."2.41Novel agents for the therapy of acute leukemia. ( Giles, FJ, 2002)
"A troxacitabine-resistant prostate cancer subline (DU145(R); 6300-fold) that exhibited reduced uptake of troxacitabine was cross-resistant to both gemcitabine (350-fold) and cytarabine (300-fold)."1.31Mechanisms of uptake and resistance to troxacitabine, a novel deoxycytidine nucleoside analogue, in human leukemic and solid tumor cell lines. ( Cass, CE; Clarke, ML; Gourdeau, H; Jolivet, J; Lafrenière, RG; Lee, N; Mackey, JR; Mowles, D; Ouellet, F; Richard, A; Selner, M; Young, JD, 2001)

Research

Studies (38)

TimeframeStudies, this research(%)All Research%
pre-199013 (34.21)18.7374
1990's0 (0.00)18.2507
2000's21 (55.26)29.6817
2010's4 (10.53)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Adelman, ER1
Huang, HT1
Roisman, A1
Olsson, A1
Colaprico, A1
Qin, T1
Lindsley, RC1
Bejar, R1
Salomonis, N1
Grimes, HL1
Figueroa, ME2
Ye, C1
Li, L1
Jeong, M1
Sun, D1
Luo, M1
Huang, Y1
Challen, GA1
Rodriguez, B1
Zhang, X1
Chavez, L1
Wang, H1
Hannah, R1
Kim, SB1
Yang, L1
Ko, M1
Chen, R1
Göttgens, B1
Lee, JS1
Gunaratne, P1
Godley, LA1
Darlington, GJ1
Rao, A1
Li, W1
Goodell, MA1
Liu, Z1
Xie, Z1
Jones, W1
Pavlovicz, RE1
Liu, S1
Yu, J1
Li, PK1
Lin, J1
Fuchs, JR1
Marcucci, G1
Li, C1
Chan, KK1
Laing, RE1
Walter, MA1
Campbell, DO1
Herschman, HR1
Satyamurthy, N1
Phelps, ME1
Czernin, J1
Witte, ON1
Radu, CG1
Melnick, A1
Greally, JM1
Kantarjian, H1
Garcia-Manero, G2
O'Brien, S2
Faderl, S1
Ravandi, F1
Westwood, R1
Green, SR1
Chiao, JH1
Boone, PA1
Cortes, J1
Plunkett, W1
Giles, FJ5
Karrison, T1
Ratain, M1
Fu, WN1
Bertoni, F1
Kelsey, SM1
McElwaine, SM1
Cotter, FE1
Newland, AC1
Jia, L1
FELISTOVICH, GO1
EVANS, JS2
BOSTWICK, L1
MENGEL, GD2
CHU, MY1
FISCHER, GA1
Gourdeau, H2
Jolivet, J4
Nouzova, M1
Holtan, N1
Oshiro, MM1
Isett, RB1
Munoz-Rodriguez, JL1
List, AF1
Narro, ML1
Miller, SJ1
Merchant, NC1
Futscher, BW1
Parry, TE1
Vose, JM1
Panwalkar, A1
Belanger, R1
Coiffier, B1
Baccarani, M1
Gregory, SA1
Facon, T1
Fanin, R1
Caballero, D1
Ben-Yehuda, D1
Giles, F3
Swords, R2
Apostolidou, E1
Bajdichova, M1
Paulikova, H1
Jakubikova, J1
Sabolova, D1
Jiemjit, A1
Fandy, TE1
Carraway, H1
Bailey, KA1
Baylin, S1
Herman, JG1
Gore, SD1
Penketh, PG1
Baumann, RP1
Ishiguro, K1
Shyam, K1
Seow, HA1
Sartorelli, AC1
Burchenal, JH1
Sawecka, J1
Kornacka, L1
Malec, J1
Bur'ianov, IaI1
Shevchuk, TV1
Zakharchenko, NS1
D'iachenko, OV1
Marinich, DV1
Vorob'ev, IA1
Cortes, JE3
Baker, SD2
Thomas, DA2
Smith, TL1
Beran, M1
Bivins, C2
Kantarjian, HM2
Clarke, ML1
Ouellet, F1
Mowles, D1
Selner, M1
Richard, A1
Lee, N1
Mackey, JR1
Young, JD1
Lafrenière, RG1
Cass, CE1
Miller, CB1
O'Brien, SM1
Andreeff, M1
Hui, YF1
Pfeifer, GP1
Steigerwald, S1
Boehm, TL1
Drahovsky, D1
Atkinson, K1
Wells, DG1
Clink, HM1
Kay, HE1
Powles, R1
McElwain, TJ1
Benvenisti, DS1
Sherwood, LM1
Heinemann, HO1
Wilfert, CM1
Nakamura, T1
Antonian, KA1
Chilingarian, AG1
Fink, K1
Adams, WS1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Phase I Pharmacologic Study of Oral Sapacitabine in Patients With Advanced Leukemias or Myelodysplastic Syndromes[NCT00380653]Phase 147 participants (Actual)Interventional2006-01-31Completed
An Open-Label, Single-Arm, Phase I Study of Troxatyl™ (Troxacitabine) Administered by Continuous Infusion in Subjects With an Advanced Solid Malignancy[NCT00104286]Phase 1/Phase 250 participants Interventional2003-01-31Terminated
An Open-Label, Single-Arm, Multi-Center, Phase I Study of Troxatyl™ (Troxacitabine) Administered by Continuous Infusion in Subjects With Refractory Acute Myelogenous Leukemia[NCT00104468]Phase 1/Phase 250 participants Interventional2003-04-30Terminated (stopped due to Trial stopped June 2007)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

8 reviews available for cytosine and Leukemia

ArticleYear
5-hydroxymethylcytosine: a new insight into epigenetics in cancer.
    Cancer biology & therapy, 2014, Volume: 15, Issue:1

    Topics: 5-Methylcytosine; Animals; Brain Neoplasms; Cytosine; Dioxygenases; DNA Methylation; DNA-Binding Pro

2014
Troxacitabine-based therapy of refractory leukemia.
    Expert review of anticancer therapy, 2002, Volume: 2, Issue:3

    Topics: Antineoplastic Combined Chemotherapy Protocols; Clinical Trials, Phase I as Topic; Clinical Trials,

2002
Troxacitabine-based therapy of refractory leukemia.
    Expert review of anticancer therapy, 2002, Volume: 2, Issue:3

    Topics: Antineoplastic Combined Chemotherapy Protocols; Clinical Trials, Phase I as Topic; Clinical Trials,

2002
Troxacitabine-based therapy of refractory leukemia.
    Expert review of anticancer therapy, 2002, Volume: 2, Issue:3

    Topics: Antineoplastic Combined Chemotherapy Protocols; Clinical Trials, Phase I as Topic; Clinical Trials,

2002
Troxacitabine-based therapy of refractory leukemia.
    Expert review of anticancer therapy, 2002, Volume: 2, Issue:3

    Topics: Antineoplastic Combined Chemotherapy Protocols; Clinical Trials, Phase I as Topic; Clinical Trials,

2002
[Troxacitabine].
    Bulletin du cancer, 2004, Volume: 91, Issue:3

    Topics: Acute Disease; Animals; Antineoplastic Agents; Clinical Trials, Phase I as Topic; Clinical Trials, P

2004
Mutagenic mechanisms in leukemia and cancer: a new concept Cytosine lack could be as mutagenic as cytosine deamination.
    Leukemia research, 2006, Volume: 30, Issue:9

    Topics: Cytosine; Deamination; DNA Methylation; DNA Repair; Humans; Leukemia; Point Mutation; Ultraviolet Ra

2006
Troxacitabine in acute leukemia.
    Hematology (Amsterdam, Netherlands), 2007, Volume: 12, Issue:3

    Topics: Antineoplastic Agents; Cytosine; Dioxolanes; Humans; Leukemia; Treatment Outcome

2007
Troxacitabine in leukemia.
    Hematology (Amsterdam, Netherlands), 2006, Volume: 11, Issue:5

    Topics: Antineoplastic Agents; Cytosine; Dioxolanes; Humans; Leukemia; Treatment Outcome

2006
Novel agents for the therapy of acute leukemia.
    Current opinion in oncology, 2002, Volume: 14, Issue:1

    Topics: Angiogenesis Inhibitors; Antineoplastic Agents; Azacitidine; Cysteine Endopeptidases; Cytosine; Deci

2002
Hypercalcemic crisis in acute leukemia.
    The American journal of medicine, 1969, Volume: 46, Issue:6

    Topics: Acute Disease; Arabinose; Bicarbonates; Blood; Blood Urea Nitrogen; Bone Marrow Examination; Calcium

1969

Trials

4 trials available for cytosine and Leukemia

ArticleYear
Phase I clinical and pharmacokinetic study of oral sapacitabine in patients with acute leukemia and myelodysplastic syndrome.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2010, Jan-10, Volume: 28, Issue:2

    Topics: Acute Disease; Administration, Oral; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Arabinon

2010
A phase II multicenter study of troxacitabine in relapsed or refractory lymphoproliferative neoplasms or multiple myeloma.
    Leukemia & lymphoma, 2007, Volume: 48, Issue:1

    Topics: Adult; Aged; Antineoplastic Agents; Cytosine; Dioxolanes; Dose-Response Relationship, Drug; Drug Res

2007
Troxacitabine, a novel dioxolane nucleoside analog, has activity in patients with advanced leukemia.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2001, Feb-01, Volume: 19, Issue:3

    Topics: Acute Disease; Adult; Aged; Antineoplastic Agents; Blast Crisis; Cytosine; Dioxolanes; Dose-Response

2001
Phase II study of troxacitabine, a novel dioxolane nucleoside analog, in patients with refractory leukemia.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2002, Feb-01, Volume: 20, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Cytosine; Dioxolanes; Female; Humans; Leukemi

2002

Other Studies

26 other studies available for cytosine and Leukemia

ArticleYear
Aging Human Hematopoietic Stem Cells Manifest Profound Epigenetic Reprogramming of Enhancers That May Predispose to Leukemia.
    Cancer discovery, 2019, Volume: 9, Issue:8

    Topics: Cell Differentiation; Cellular Reprogramming; Cellular Senescence; Cytosine; Disease Susceptibility;

2019
Large conserved domains of low DNA methylation maintained by Dnmt3a.
    Nature genetics, 2014, Volume: 46, Issue:1

    Topics: 5-Methylcytosine; Animals; Base Sequence; Conserved Sequence; CpG Islands; Cytosine; Databases, Gene

2014
Curcumin is a potent DNA hypomethylation agent.
    Bioorganic & medicinal chemistry letters, 2009, Feb-01, Volume: 19, Issue:3

    Topics: Catalysis; Catalytic Domain; Cell Line, Tumor; Curcumin; Cytosine; DNA (Cytosine-5-)-Methyltransfera

2009
Noninvasive prediction of tumor responses to gemcitabine using positron emission tomography.
    Proceedings of the National Academy of Sciences of the United States of America, 2009, Feb-24, Volume: 106, Issue:8

    Topics: Animals; Antineoplastic Agents; Cytosine; Deoxycytidine; Gemcitabine; Humans; Leukemia; Mice; Positr

2009
Genome-wide determination of DNA methylation by Hpa II tiny fragment enrichment by ligation-mediated PCR (HELP) for the study of acute leukemias.
    Methods in molecular biology (Clifton, N.J.), 2009, Volume: 538

    Topics: Acute Disease; CpG Islands; Cytosine; DNA; DNA Methylation; DNA-Cytosine Methylases; Genome, Human;

2009
Troxacitabine in patients with refractory leukemia.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2002, Aug-01, Volume: 20, Issue:15

    Topics: Antineoplastic Agents; Area Under Curve; Clinical Trials, Phase II as Topic; Cytosine; Dioxolanes; H

2002
Role of DNA methylation in the suppression of Apaf-1 protein in human leukaemia.
    Oncogene, 2003, Jan-23, Volume: 22, Issue:3

    Topics: Apoptosis; Apoptotic Protease-Activating Factor 1; Azacitidine; Cytosine; Decitabine; DNA Methylatio

2003
[Effect of cytosine on the course of spontaneous leukemia in afb mice].
    Voprosy onkologii, 1959, Volume: 5, Issue:4

    Topics: Animals; Cytosine; Leukemia; Leukemia, Experimental; Mice; Pyrimidines

1959
SYNERGISM OF THE ANTINEOPLASTIC ACTIVITY OF CYTOSINE ARABINOSIDE BY PORFIROMYCIN.
    Biochemical pharmacology, 1964, Volume: 13

    Topics: Animals; Anti-Bacterial Agents; Antineoplastic Agents; Body Weight; Cytarabine; Cytosine; Leukemia;

1964
THE REVERSAL OF CYTOSINE ARABINOSIDE ACTIVITY IN VIVO BY DEOXYCYTIDINE.
    Biochemical pharmacology, 1964, Volume: 13

    Topics: Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Cytarabine; Cytosine; Deoxycytidine; Leuke

1964
COMPARATIVE STUDIES OF LEUKEMIC CELLS SENSITIVE AND RESISTANT TO CYTOSINE ARABINOSIDE.
    Biochemical pharmacology, 1965, Volume: 14

    Topics: Adenosine Triphosphate; Antineoplastic Agents; Chromatography; Cytarabine; Cytosine; DNA; DNA, Neopl

1965
Epigenomic changes during leukemia cell differentiation: analysis of histone acetylation and cytosine methylation using CpG island microarrays.
    The Journal of pharmacology and experimental therapeutics, 2004, Volume: 311, Issue:3

    Topics: Acetylation; Cell Differentiation; Chromatin; CpG Islands; Cytosine; Databases, Genetic; DNA; Gene L

2004
Comparison of inhibition of murine leukaemia cell growth by 9-isothiocyanatoacridine and its cytosine adduct: involvement of thiols.
    Neoplasma, 2007, Volume: 54, Issue:6

    Topics: Acridines; Animals; Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Membrane; Cell Proliferation; Cyto

2007
p21(WAF1/CIP1) induction by 5-azacytosine nucleosides requires DNA damage.
    Oncogene, 2008, Jun-05, Volume: 27, Issue:25

    Topics: Caffeine; Cell Line, Tumor; CpG Islands; Cyclin-Dependent Kinase Inhibitor p21; Cytosine; DNA Damage

2008
Lethality to leukemia cell lines of DNA interstrand cross-links generated by Cloretazine derived alkylating species.
    Leukemia research, 2008, Volume: 32, Issue:10

    Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cross-Linking Reagents; Cytosine; DNA; Ethane; Gua

2008
Geographic chemotherapy--Burkitt's tumor as a stalking horse for leukemia: presidential address.
    Cancer research, 1966, Volume: 26, Issue:12

    Topics: Adult; Africa; Antineoplastic Agents; Child; Cytosine; Female; Follow-Up Studies; Geography; Humans;

1966
Intragenomic distribution of 5-methylcytosine in various forms of human and murine leukemic cells.
    Neoplasma, 1980, Volume: 27, Issue:2

    Topics: 5-Methylcytosine; Animals; Chromatin; Cytosine; Deoxyribonucleases; DNA, Neoplasm; Humans; Leukemia;

1980
[The lack of the CpNpG methylation at the 5'-terminal region of the human calcitonin gene in norm and in leukemia [].
    Bioorganicheskaia khimiia, 2000, Volume: 26, Issue:5

    Topics: 5' Untranslated Regions; Calcitonin; Cytosine; DNA Methylation; Humans; Leukemia

2000
Mechanisms of uptake and resistance to troxacitabine, a novel deoxycytidine nucleoside analogue, in human leukemic and solid tumor cell lines.
    Cancer research, 2001, Oct-01, Volume: 61, Issue:19

    Topics: Amino Acid Sequence; Antineoplastic Agents; Biological Transport; Carrier Proteins; Cytarabine; Cyti

2001
Chemotherapy-induced palmar-plantar erythrodysesthesia syndrome--recall following different chemotherapy agents.
    Investigational new drugs, 2002, Volume: 20, Issue:1

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Cytosine; Dioxolanes; Erythema; Female; Foot;

2002
DNA methylation levels in acute human leukemia.
    Cancer letters, 1988, Volume: 39, Issue:2

    Topics: 5-Methylcytosine; Acute Disease; Cytosine; DNA, Neoplasm; Humans; Leukemia; Methylation

1988
Adult acute leukaemia.
    British journal of cancer, 1974, Volume: 30, Issue:3

    Topics: Acute Disease; Administration, Oral; Adult; Aged; Antineoplastic Agents; Cyclophosphamide; Cytarabin

1974
Disseminated varicella in a patient with leukemia.
    The Journal of pediatrics, 1971, Volume: 79, Issue:1

    Topics: Adult; Antiviral Agents; Chickenpox; Child; Cytosine; Female; Humans; Immunologic Deficiency Syndrom

1971
[Effects of antileukemic agents on nucleic acid metabolism of human leukemic leukocytes with special reference to hematological effects of the agents].
    Nihon Ketsueki Gakkai zasshi : journal of Japan Haematological Society, 1969, Volume: 32, Issue:1

    Topics: Acute Disease; Autoradiography; Cytosine; Humans; Leukemia; Leukocytes; Mercaptopurine; Nucleic Acid

1969
[Effect of thymine, cystosine and 6-mercaptopurine on the course of implanted leukosis in mice].
    Zhurnal eksperimental'noi i klinicheskoi meditsiny, 1970, Volume: 10, Issue:2

    Topics: Animals; Cytosine; Leukemia; Leukemia, Experimental; Leukemia, Lymphoid; Mercaptopurine; Mice; Thymi

1970
Urinary purines and pyrimidines in normal and leukemic subjects.
    Archives of biochemistry and biophysics, 1968, Volume: 126, Issue:1

    Topics: Chromatography, Ion Exchange; Cytosine; Cytosine Nucleotides; Electrophoresis; Humans; Leukemia; Nuc

1968