cytosine has been researched along with Leukemia in 38 studies
Leukemia: A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)
| Excerpt | Relevance | Reference |
|---|---|---|
| "To investigate the activity of a novel dioxolane L-nucleoside analog, troxacitabine (L-(-)-OddC, BCH-4556), in patients with refractory leukemia." | 9.10 | Phase II study of troxacitabine, a novel dioxolane nucleoside analog, in patients with refractory leukemia. ( Andreeff, M; Baker, SD; Bivins, C; Cortes, JE; Garcia-Manero, G; Giles, FJ; Jolivet, J; Kantarjian, HM; Miller, CB; O'Brien, SM; Thomas, DA, 2002) |
| "To investigate the toxicity profile, activity, and pharmacokinetics of a novel L-nucleoside analog, troxacitabine (BCH-4556), in patients with advanced leukemia." | 9.09 | Troxacitabine, a novel dioxolane nucleoside analog, has activity in patients with advanced leukemia. ( Baker, SD; Beran, M; Bivins, C; Cortes, JE; Giles, FJ; Jolivet, J; Kantarjian, HM; O'Brien, S; Smith, TL; Thomas, DA, 2001) |
| " Future studies will be needed to address modified dosing according to emerging pharmacokinetic and pharmacodynamic data and combination therapy which may lead to improved clinical benefit for troxacitabine in hematologic malignancies." | 6.73 | A phase II multicenter study of troxacitabine in relapsed or refractory lymphoproliferative neoplasms or multiple myeloma. ( Baccarani, M; Belanger, R; Ben-Yehuda, D; Caballero, D; Coiffier, B; Facon, T; Fanin, R; Giles, F; Gregory, SA; Panwalkar, A; Vose, JM, 2007) |
| "To investigate the activity of a novel dioxolane L-nucleoside analog, troxacitabine (L-(-)-OddC, BCH-4556), in patients with refractory leukemia." | 5.10 | Phase II study of troxacitabine, a novel dioxolane nucleoside analog, in patients with refractory leukemia. ( Andreeff, M; Baker, SD; Bivins, C; Cortes, JE; Garcia-Manero, G; Giles, FJ; Jolivet, J; Kantarjian, HM; Miller, CB; O'Brien, SM; Thomas, DA, 2002) |
| "To investigate the toxicity profile, activity, and pharmacokinetics of a novel L-nucleoside analog, troxacitabine (BCH-4556), in patients with advanced leukemia." | 5.09 | Troxacitabine, a novel dioxolane nucleoside analog, has activity in patients with advanced leukemia. ( Baker, SD; Beran, M; Bivins, C; Cortes, JE; Giles, FJ; Jolivet, J; Kantarjian, HM; O'Brien, S; Smith, TL; Thomas, DA, 2001) |
| "Cloretazine [1,2-bis(methylsulfonyl)-1-(2-chloroethyl)-2-[(methylamino)carbonyl]hydrazine; VNP40101M; 101M] is a relatively new prodrug with activity in elderly acute myelogenous leukemia (AML) patients." | 3.74 | Lethality to leukemia cell lines of DNA interstrand cross-links generated by Cloretazine derived alkylating species. ( Baumann, RP; Ishiguro, K; Penketh, PG; Sartorelli, AC; Seow, HA; Shyam, K, 2008) |
| " Troxacitabine is an anti-leukemic agent which can be associated with palmar-plantar erythrodysesthesia syndrome (PPES)." | 3.71 | Chemotherapy-induced palmar-plantar erythrodysesthesia syndrome--recall following different chemotherapy agents. ( Cortes, JE; Giles, FJ; Hui, YF, 2002) |
| "The inner cytosine methylation was analyzed in the CCWGG sequences of the 5'-terminal region of the human calcitonin gene from peripheral blood and bone marrow cells in various forms of leukemia." | 3.70 | [The lack of the CpNpG methylation at the 5'-terminal region of the human calcitonin gene in norm and in leukemia []. ( Bur'ianov, IaI; D'iachenko, OV; Marinich, DV; Shevchuk, TV; Vorob'ev, IA; Zakharchenko, NS, 2000) |
| "We have studied the overall 5-methylcytosine content and the percentage of methylated CpG-dinucleotides in 25 cases of untreated human acute leukemias." | 3.67 | DNA methylation levels in acute human leukemia. ( Boehm, TL; Drahovsky, D; Pfeifer, GP; Steigerwald, S, 1988) |
| "The degree of 5-methylcytosine formation in DNA sequences differing in reassociation rate and susceptibility to DNase II digestion has been investigated in human chronic myelogenic leukemia and acute leukemia leukocytes, human PHA-stimulated lymphocytes and murine L5178Y lymphoblasts cultured in various phases of growth." | 3.66 | Intragenomic distribution of 5-methylcytosine in various forms of human and murine leukemic cells. ( Kornacka, L; Malec, J; Sawecka, J, 1980) |
| " Future studies will be needed to address modified dosing according to emerging pharmacokinetic and pharmacodynamic data and combination therapy which may lead to improved clinical benefit for troxacitabine in hematologic malignancies." | 2.73 | A phase II multicenter study of troxacitabine in relapsed or refractory lymphoproliferative neoplasms or multiple myeloma. ( Baccarani, M; Belanger, R; Ben-Yehuda, D; Caballero, D; Coiffier, B; Facon, T; Fanin, R; Giles, F; Gregory, SA; Panwalkar, A; Vose, JM, 2007) |
| "The leukemias are complex diseases with a wide range of clinical, morphologic, biologic, molecular, and clinical features and a consequent array of possible responses to any given intervention." | 2.41 | Novel agents for the therapy of acute leukemia. ( Giles, FJ, 2002) |
| "A troxacitabine-resistant prostate cancer subline (DU145(R); 6300-fold) that exhibited reduced uptake of troxacitabine was cross-resistant to both gemcitabine (350-fold) and cytarabine (300-fold)." | 1.31 | Mechanisms of uptake and resistance to troxacitabine, a novel deoxycytidine nucleoside analogue, in human leukemic and solid tumor cell lines. ( Cass, CE; Clarke, ML; Gourdeau, H; Jolivet, J; Lafrenière, RG; Lee, N; Mackey, JR; Mowles, D; Ouellet, F; Richard, A; Selner, M; Young, JD, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (34.21) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 21 (55.26) | 29.6817 |
| 2010's | 4 (10.53) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Adelman, ER | 1 |
| Huang, HT | 1 |
| Roisman, A | 1 |
| Olsson, A | 1 |
| Colaprico, A | 1 |
| Qin, T | 1 |
| Lindsley, RC | 1 |
| Bejar, R | 1 |
| Salomonis, N | 1 |
| Grimes, HL | 1 |
| Figueroa, ME | 2 |
| Ye, C | 1 |
| Li, L | 1 |
| Jeong, M | 1 |
| Sun, D | 1 |
| Luo, M | 1 |
| Huang, Y | 1 |
| Challen, GA | 1 |
| Rodriguez, B | 1 |
| Zhang, X | 1 |
| Chavez, L | 1 |
| Wang, H | 1 |
| Hannah, R | 1 |
| Kim, SB | 1 |
| Yang, L | 1 |
| Ko, M | 1 |
| Chen, R | 1 |
| Göttgens, B | 1 |
| Lee, JS | 1 |
| Gunaratne, P | 1 |
| Godley, LA | 1 |
| Darlington, GJ | 1 |
| Rao, A | 1 |
| Li, W | 1 |
| Goodell, MA | 1 |
| Liu, Z | 1 |
| Xie, Z | 1 |
| Jones, W | 1 |
| Pavlovicz, RE | 1 |
| Liu, S | 1 |
| Yu, J | 1 |
| Li, PK | 1 |
| Lin, J | 1 |
| Fuchs, JR | 1 |
| Marcucci, G | 1 |
| Li, C | 1 |
| Chan, KK | 1 |
| Laing, RE | 1 |
| Walter, MA | 1 |
| Campbell, DO | 1 |
| Herschman, HR | 1 |
| Satyamurthy, N | 1 |
| Phelps, ME | 1 |
| Czernin, J | 1 |
| Witte, ON | 1 |
| Radu, CG | 1 |
| Melnick, A | 1 |
| Greally, JM | 1 |
| Kantarjian, H | 1 |
| Garcia-Manero, G | 2 |
| O'Brien, S | 2 |
| Faderl, S | 1 |
| Ravandi, F | 1 |
| Westwood, R | 1 |
| Green, SR | 1 |
| Chiao, JH | 1 |
| Boone, PA | 1 |
| Cortes, J | 1 |
| Plunkett, W | 1 |
| Giles, FJ | 5 |
| Karrison, T | 1 |
| Ratain, M | 1 |
| Fu, WN | 1 |
| Bertoni, F | 1 |
| Kelsey, SM | 1 |
| McElwaine, SM | 1 |
| Cotter, FE | 1 |
| Newland, AC | 1 |
| Jia, L | 1 |
| FELISTOVICH, GO | 1 |
| EVANS, JS | 2 |
| BOSTWICK, L | 1 |
| MENGEL, GD | 2 |
| CHU, MY | 1 |
| FISCHER, GA | 1 |
| Gourdeau, H | 2 |
| Jolivet, J | 4 |
| Nouzova, M | 1 |
| Holtan, N | 1 |
| Oshiro, MM | 1 |
| Isett, RB | 1 |
| Munoz-Rodriguez, JL | 1 |
| List, AF | 1 |
| Narro, ML | 1 |
| Miller, SJ | 1 |
| Merchant, NC | 1 |
| Futscher, BW | 1 |
| Parry, TE | 1 |
| Vose, JM | 1 |
| Panwalkar, A | 1 |
| Belanger, R | 1 |
| Coiffier, B | 1 |
| Baccarani, M | 1 |
| Gregory, SA | 1 |
| Facon, T | 1 |
| Fanin, R | 1 |
| Caballero, D | 1 |
| Ben-Yehuda, D | 1 |
| Giles, F | 3 |
| Swords, R | 2 |
| Apostolidou, E | 1 |
| Bajdichova, M | 1 |
| Paulikova, H | 1 |
| Jakubikova, J | 1 |
| Sabolova, D | 1 |
| Jiemjit, A | 1 |
| Fandy, TE | 1 |
| Carraway, H | 1 |
| Bailey, KA | 1 |
| Baylin, S | 1 |
| Herman, JG | 1 |
| Gore, SD | 1 |
| Penketh, PG | 1 |
| Baumann, RP | 1 |
| Ishiguro, K | 1 |
| Shyam, K | 1 |
| Seow, HA | 1 |
| Sartorelli, AC | 1 |
| Burchenal, JH | 1 |
| Sawecka, J | 1 |
| Kornacka, L | 1 |
| Malec, J | 1 |
| Bur'ianov, IaI | 1 |
| Shevchuk, TV | 1 |
| Zakharchenko, NS | 1 |
| D'iachenko, OV | 1 |
| Marinich, DV | 1 |
| Vorob'ev, IA | 1 |
| Cortes, JE | 3 |
| Baker, SD | 2 |
| Thomas, DA | 2 |
| Smith, TL | 1 |
| Beran, M | 1 |
| Bivins, C | 2 |
| Kantarjian, HM | 2 |
| Clarke, ML | 1 |
| Ouellet, F | 1 |
| Mowles, D | 1 |
| Selner, M | 1 |
| Richard, A | 1 |
| Lee, N | 1 |
| Mackey, JR | 1 |
| Young, JD | 1 |
| Lafrenière, RG | 1 |
| Cass, CE | 1 |
| Miller, CB | 1 |
| O'Brien, SM | 1 |
| Andreeff, M | 1 |
| Hui, YF | 1 |
| Pfeifer, GP | 1 |
| Steigerwald, S | 1 |
| Boehm, TL | 1 |
| Drahovsky, D | 1 |
| Atkinson, K | 1 |
| Wells, DG | 1 |
| Clink, HM | 1 |
| Kay, HE | 1 |
| Powles, R | 1 |
| McElwain, TJ | 1 |
| Benvenisti, DS | 1 |
| Sherwood, LM | 1 |
| Heinemann, HO | 1 |
| Wilfert, CM | 1 |
| Nakamura, T | 1 |
| Antonian, KA | 1 |
| Chilingarian, AG | 1 |
| Fink, K | 1 |
| Adams, WS | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase I Pharmacologic Study of Oral Sapacitabine in Patients With Advanced Leukemias or Myelodysplastic Syndromes[NCT00380653] | Phase 1 | 47 participants (Actual) | Interventional | 2006-01-31 | Completed | ||
| An Open-Label, Single-Arm, Phase I Study of Troxatyl™ (Troxacitabine) Administered by Continuous Infusion in Subjects With an Advanced Solid Malignancy[NCT00104286] | Phase 1/Phase 2 | 50 participants | Interventional | 2003-01-31 | Terminated | ||
| An Open-Label, Single-Arm, Multi-Center, Phase I Study of Troxatyl™ (Troxacitabine) Administered by Continuous Infusion in Subjects With Refractory Acute Myelogenous Leukemia[NCT00104468] | Phase 1/Phase 2 | 50 participants | Interventional | 2003-04-30 | Terminated (stopped due to Trial stopped June 2007) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
8 reviews available for cytosine and Leukemia
| Article | Year |
|---|---|
5-hydroxymethylcytosine: a new insight into epigenetics in cancer.
Topics: 5-Methylcytosine; Animals; Brain Neoplasms; Cytosine; Dioxygenases; DNA Methylation; DNA-Binding Pro | 2014 |
Troxacitabine-based therapy of refractory leukemia.
Topics: Antineoplastic Combined Chemotherapy Protocols; Clinical Trials, Phase I as Topic; Clinical Trials, | 2002 |
Troxacitabine-based therapy of refractory leukemia.
Topics: Antineoplastic Combined Chemotherapy Protocols; Clinical Trials, Phase I as Topic; Clinical Trials, | 2002 |
Troxacitabine-based therapy of refractory leukemia.
Topics: Antineoplastic Combined Chemotherapy Protocols; Clinical Trials, Phase I as Topic; Clinical Trials, | 2002 |
Troxacitabine-based therapy of refractory leukemia.
Topics: Antineoplastic Combined Chemotherapy Protocols; Clinical Trials, Phase I as Topic; Clinical Trials, | 2002 |
[Troxacitabine].
Topics: Acute Disease; Animals; Antineoplastic Agents; Clinical Trials, Phase I as Topic; Clinical Trials, P | 2004 |
Mutagenic mechanisms in leukemia and cancer: a new concept Cytosine lack could be as mutagenic as cytosine deamination.
Topics: Cytosine; Deamination; DNA Methylation; DNA Repair; Humans; Leukemia; Point Mutation; Ultraviolet Ra | 2006 |
Troxacitabine in acute leukemia.
Topics: Antineoplastic Agents; Cytosine; Dioxolanes; Humans; Leukemia; Treatment Outcome | 2007 |
Troxacitabine in leukemia.
Topics: Antineoplastic Agents; Cytosine; Dioxolanes; Humans; Leukemia; Treatment Outcome | 2006 |
Novel agents for the therapy of acute leukemia.
Topics: Angiogenesis Inhibitors; Antineoplastic Agents; Azacitidine; Cysteine Endopeptidases; Cytosine; Deci | 2002 |
Hypercalcemic crisis in acute leukemia.
Topics: Acute Disease; Arabinose; Bicarbonates; Blood; Blood Urea Nitrogen; Bone Marrow Examination; Calcium | 1969 |
4 trials available for cytosine and Leukemia
| Article | Year |
|---|---|
Phase I clinical and pharmacokinetic study of oral sapacitabine in patients with acute leukemia and myelodysplastic syndrome.
Topics: Acute Disease; Administration, Oral; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Arabinon | 2010 |
A phase II multicenter study of troxacitabine in relapsed or refractory lymphoproliferative neoplasms or multiple myeloma.
Topics: Adult; Aged; Antineoplastic Agents; Cytosine; Dioxolanes; Dose-Response Relationship, Drug; Drug Res | 2007 |
Troxacitabine, a novel dioxolane nucleoside analog, has activity in patients with advanced leukemia.
Topics: Acute Disease; Adult; Aged; Antineoplastic Agents; Blast Crisis; Cytosine; Dioxolanes; Dose-Response | 2001 |
Phase II study of troxacitabine, a novel dioxolane nucleoside analog, in patients with refractory leukemia.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Cytosine; Dioxolanes; Female; Humans; Leukemi | 2002 |
26 other studies available for cytosine and Leukemia
| Article | Year |
|---|---|
Aging Human Hematopoietic Stem Cells Manifest Profound Epigenetic Reprogramming of Enhancers That May Predispose to Leukemia.
Topics: Cell Differentiation; Cellular Reprogramming; Cellular Senescence; Cytosine; Disease Susceptibility; | 2019 |
Large conserved domains of low DNA methylation maintained by Dnmt3a.
Topics: 5-Methylcytosine; Animals; Base Sequence; Conserved Sequence; CpG Islands; Cytosine; Databases, Gene | 2014 |
Curcumin is a potent DNA hypomethylation agent.
Topics: Catalysis; Catalytic Domain; Cell Line, Tumor; Curcumin; Cytosine; DNA (Cytosine-5-)-Methyltransfera | 2009 |
Noninvasive prediction of tumor responses to gemcitabine using positron emission tomography.
Topics: Animals; Antineoplastic Agents; Cytosine; Deoxycytidine; Gemcitabine; Humans; Leukemia; Mice; Positr | 2009 |
Genome-wide determination of DNA methylation by Hpa II tiny fragment enrichment by ligation-mediated PCR (HELP) for the study of acute leukemias.
Topics: Acute Disease; CpG Islands; Cytosine; DNA; DNA Methylation; DNA-Cytosine Methylases; Genome, Human; | 2009 |
Troxacitabine in patients with refractory leukemia.
Topics: Antineoplastic Agents; Area Under Curve; Clinical Trials, Phase II as Topic; Cytosine; Dioxolanes; H | 2002 |
Role of DNA methylation in the suppression of Apaf-1 protein in human leukaemia.
Topics: Apoptosis; Apoptotic Protease-Activating Factor 1; Azacitidine; Cytosine; Decitabine; DNA Methylatio | 2003 |
[Effect of cytosine on the course of spontaneous leukemia in afb mice].
Topics: Animals; Cytosine; Leukemia; Leukemia, Experimental; Mice; Pyrimidines | 1959 |
SYNERGISM OF THE ANTINEOPLASTIC ACTIVITY OF CYTOSINE ARABINOSIDE BY PORFIROMYCIN.
Topics: Animals; Anti-Bacterial Agents; Antineoplastic Agents; Body Weight; Cytarabine; Cytosine; Leukemia; | 1964 |
THE REVERSAL OF CYTOSINE ARABINOSIDE ACTIVITY IN VIVO BY DEOXYCYTIDINE.
Topics: Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Cytarabine; Cytosine; Deoxycytidine; Leuke | 1964 |
COMPARATIVE STUDIES OF LEUKEMIC CELLS SENSITIVE AND RESISTANT TO CYTOSINE ARABINOSIDE.
Topics: Adenosine Triphosphate; Antineoplastic Agents; Chromatography; Cytarabine; Cytosine; DNA; DNA, Neopl | 1965 |
Epigenomic changes during leukemia cell differentiation: analysis of histone acetylation and cytosine methylation using CpG island microarrays.
Topics: Acetylation; Cell Differentiation; Chromatin; CpG Islands; Cytosine; Databases, Genetic; DNA; Gene L | 2004 |
Comparison of inhibition of murine leukaemia cell growth by 9-isothiocyanatoacridine and its cytosine adduct: involvement of thiols.
Topics: Acridines; Animals; Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Membrane; Cell Proliferation; Cyto | 2007 |
p21(WAF1/CIP1) induction by 5-azacytosine nucleosides requires DNA damage.
Topics: Caffeine; Cell Line, Tumor; CpG Islands; Cyclin-Dependent Kinase Inhibitor p21; Cytosine; DNA Damage | 2008 |
Lethality to leukemia cell lines of DNA interstrand cross-links generated by Cloretazine derived alkylating species.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cross-Linking Reagents; Cytosine; DNA; Ethane; Gua | 2008 |
Geographic chemotherapy--Burkitt's tumor as a stalking horse for leukemia: presidential address.
Topics: Adult; Africa; Antineoplastic Agents; Child; Cytosine; Female; Follow-Up Studies; Geography; Humans; | 1966 |
Intragenomic distribution of 5-methylcytosine in various forms of human and murine leukemic cells.
Topics: 5-Methylcytosine; Animals; Chromatin; Cytosine; Deoxyribonucleases; DNA, Neoplasm; Humans; Leukemia; | 1980 |
[The lack of the CpNpG methylation at the 5'-terminal region of the human calcitonin gene in norm and in leukemia [].
Topics: 5' Untranslated Regions; Calcitonin; Cytosine; DNA Methylation; Humans; Leukemia | 2000 |
Mechanisms of uptake and resistance to troxacitabine, a novel deoxycytidine nucleoside analogue, in human leukemic and solid tumor cell lines.
Topics: Amino Acid Sequence; Antineoplastic Agents; Biological Transport; Carrier Proteins; Cytarabine; Cyti | 2001 |
Chemotherapy-induced palmar-plantar erythrodysesthesia syndrome--recall following different chemotherapy agents.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Cytosine; Dioxolanes; Erythema; Female; Foot; | 2002 |
DNA methylation levels in acute human leukemia.
Topics: 5-Methylcytosine; Acute Disease; Cytosine; DNA, Neoplasm; Humans; Leukemia; Methylation | 1988 |
Adult acute leukaemia.
Topics: Acute Disease; Administration, Oral; Adult; Aged; Antineoplastic Agents; Cyclophosphamide; Cytarabin | 1974 |
Disseminated varicella in a patient with leukemia.
Topics: Adult; Antiviral Agents; Chickenpox; Child; Cytosine; Female; Humans; Immunologic Deficiency Syndrom | 1971 |
[Effects of antileukemic agents on nucleic acid metabolism of human leukemic leukocytes with special reference to hematological effects of the agents].
Topics: Acute Disease; Autoradiography; Cytosine; Humans; Leukemia; Leukocytes; Mercaptopurine; Nucleic Acid | 1969 |
[Effect of thymine, cystosine and 6-mercaptopurine on the course of implanted leukosis in mice].
Topics: Animals; Cytosine; Leukemia; Leukemia, Experimental; Leukemia, Lymphoid; Mercaptopurine; Mice; Thymi | 1970 |
Urinary purines and pyrimidines in normal and leukemic subjects.
Topics: Chromatography, Ion Exchange; Cytosine; Cytosine Nucleotides; Electrophoresis; Humans; Leukemia; Nuc | 1968 |