cytosine has been researched along with Hypertension in 30 studies
Hypertension: Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Patients with mild-to-moderate primary hypertension and left ventricular hypertrophy were randomized in a double-blind study to receive treatment with either the angiotensin II type 1 (AT1) receptor antagonist irbesartan (n = 43), or the beta1-adrenergic receptor blocker atenolol (n = 43)." | 9.10 | Aldosterone synthase (CYP11B2) -344 C/T polymorphism is related to antihypertensive response: result from the Swedish Irbesartan Left Ventricular Hypertrophy Investigation versus Atenolol (SILVHIA) trial. ( Hägg, A; Kahan, T; Karlsson, J; Kurland, L; Lind, L; Malmqvist, K; Melhus, H; Nyström, F; Ohman, P, 2002) |
| "The angiotensinogen (AGT) gene has been implicated as a risk factor in essential hypertension." | 5.33 | Angiotensinogen promoter sequence variants in essential hypertension. ( Guruju, M; Kumar, A; Prater, A; Velez, DR; Vinukonda, G; Williams, SM, 2006) |
| "Patients with mild-to-moderate primary hypertension and left ventricular hypertrophy were randomized in a double-blind study to receive treatment with either the angiotensin II type 1 (AT1) receptor antagonist irbesartan (n = 43), or the beta1-adrenergic receptor blocker atenolol (n = 43)." | 5.10 | Aldosterone synthase (CYP11B2) -344 C/T polymorphism is related to antihypertensive response: result from the Swedish Irbesartan Left Ventricular Hypertrophy Investigation versus Atenolol (SILVHIA) trial. ( Hägg, A; Kahan, T; Karlsson, J; Kurland, L; Lind, L; Malmqvist, K; Melhus, H; Nyström, F; Ohman, P, 2002) |
| "A thymidine-to-cytosine substitution in the -344 promoter region of the aldosterone synthase gene (CYP11B2) has been associated with essential hypertension in some but not all studies conducted in Chinese." | 4.85 | Association between aldosterone synthase CYP11B2 polymorphism and essential hypertension in Chinese: a meta-analysis. ( Cheng, X; Xu, G, 2009) |
| " Given the potential importance of epigenetic events in hypertension, we have analyzed 5hmC and 5-methylcytosine (5mC) at single-base resolution in the renal outer medulla of the Dahl salt-sensitive rat and examined the effect of disease-relevant genetic or environmental alterations on 5hmC and 5mC patterns." | 3.80 | Base-resolution maps of 5-methylcytosine and 5-hydroxymethylcytosine in Dahl S rats: effect of salt and genomic sequence. ( Cowley, AW; Liang, M; Liu, P; Liu, Y; Yang, C, 2014) |
| " The adenine/cytosine(1166) (A/C(1166)) polymorphism of the AGT1R gene has been shown to be associated with hypertension and hypertension-related diseases." | 3.75 | Adenine/cytosine(1166) polymorphism of the angiotensin II type 1 receptor gene and the antihypertensive response to angiotensin-converting enzyme inhibitors. ( Jin, L; Lin, S; Liu, G; Yu, H; Yu, Y; Zhang, Y; Zhong, J, 2009) |
| "Hypertension is a very common cardiovascular disease influenced by multiple genetic and environmental factors." | 1.40 | Molecular characterization of a Chinese family carrying a novel C4329A mutation in mitochondrial tRNAIle and tRNAGln genes. ( Chen, Y; Gao, J; Guan, M; Lan, Y; Li, Y; Li, Z; Liu, Y; Yang, J; Zhu, C, 2014) |
| "Coronary heart disease (CHD) and chronic periodontitis (CP) both are multifactorial chronic diseases and related to inflammation." | 1.37 | Coronary heart disease and chronic periodontitis: is polymorphism of interleukin-6 gene the common risk factor in a Chinese population? ( Fan, WH; Liu, DL; Sun, SY; Xiao, LM; Xie, CJ; Zhang, JC, 2011) |
| "The etiology of preeclampsia (PE) is unknown, but endothelial cell injury plays a pivotal role." | 1.33 | Association of apolipoprotein J gene 866C-->T polymorphism with preeclampsia and essential hypertension. ( Chen, M; Shan, K; Yuan, Z, 2005) |
| "The angiotensinogen (AGT) gene has been implicated as a risk factor in essential hypertension." | 1.33 | Angiotensinogen promoter sequence variants in essential hypertension. ( Guruju, M; Kumar, A; Prater, A; Velez, DR; Vinukonda, G; Williams, SM, 2006) |
| "Treatment with atenolol did not change PIP and KLV in either subgroup of hypertensives." | 1.32 | The A1166C polymorphism of the AT1 receptor gene is associated with collagen type I synthesis and myocardial stiffness in hypertensives. ( Beloqui, O; Díez, J; González, A; Laviades, C; López, B; Mayor, G; Orbe, J; Páramo, JA; Zalba, G, 2003) |
| "A cytosine deletion was identified by genomic DNA sequencing of the apo A-I gene of the patient at the third base of codon 184 in the fourth exon, which led to a frame shift mutation and early termination at codon 200." | 1.31 | Apolipoprotein A-I deficiency with accumulated risk for CHD but no symptoms of CHD. ( Hashimoto, Y; Kawamura, M; Kitamura, K; Kotani, K; Mashige, F; Nakahara, K; Okubo, S; Shimada, S; Usuki, Y; Yokota, H; Yumoto, M, 2002) |
| "Hypertension is a common multifactorial disorder associated with considerable morbidity and mortality." | 1.30 | The diagnosis of Liddle syndrome by identification of a mutation in the beta subunit of the epithelial sodium channel. ( Houtman, P; Jackson, SN; Trembath, RC; Williams, B, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (3.33) | 18.7374 |
| 1990's | 2 (6.67) | 18.2507 |
| 2000's | 23 (76.67) | 29.6817 |
| 2010's | 4 (13.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, Y | 2 |
| Liu, P | 1 |
| Yang, C | 1 |
| Cowley, AW | 1 |
| Liang, M | 1 |
| Li, Y | 1 |
| Gao, J | 1 |
| Zhu, C | 1 |
| Lan, Y | 1 |
| Yang, J | 2 |
| Li, Z | 1 |
| Guan, M | 1 |
| Chen, Y | 2 |
| Cheng, X | 1 |
| Xu, G | 1 |
| Yu, H | 1 |
| Lin, S | 1 |
| Jin, L | 1 |
| Yu, Y | 1 |
| Zhong, J | 1 |
| Zhang, Y | 1 |
| Liu, G | 1 |
| Fan, WH | 1 |
| Liu, DL | 1 |
| Xiao, LM | 1 |
| Xie, CJ | 1 |
| Sun, SY | 1 |
| Zhang, JC | 1 |
| Pigossi, SC | 1 |
| Alvim-Pereira, F | 1 |
| Montes, CC | 1 |
| Finoti, LS | 1 |
| Secolin, R | 1 |
| Trevilatto, PC | 1 |
| Scarel-Caminaga, RM | 1 |
| Beige, J | 1 |
| Kreutz, R | 1 |
| Tscherkaschina, I | 1 |
| Scherer, S | 1 |
| Sharma, AM | 1 |
| Zidek, W | 1 |
| Offermann, G | 1 |
| Jin, JJ | 1 |
| Nakura, J | 1 |
| Wu, Z | 1 |
| Yamamoto, M | 1 |
| Abe, M | 1 |
| Tabara, Y | 1 |
| Yamamoto, Y | 1 |
| Igase, M | 1 |
| Bo, X | 1 |
| Kohara, K | 1 |
| Miki, T | 1 |
| Díez, J | 1 |
| Laviades, C | 1 |
| Orbe, J | 1 |
| Zalba, G | 1 |
| López, B | 1 |
| González, A | 1 |
| Mayor, G | 1 |
| Páramo, JA | 1 |
| Beloqui, O | 1 |
| Huang, G | 1 |
| Niu, T | 1 |
| Peng, S | 1 |
| Ling, D | 1 |
| Liu, J | 1 |
| Zhang, X | 1 |
| Xu, X | 1 |
| Zhang, L | 1 |
| Rao, F | 1 |
| Wessel, J | 1 |
| Kennedy, BP | 1 |
| Rana, BK | 1 |
| Taupenot, L | 1 |
| Lillie, EO | 1 |
| Cockburn, M | 1 |
| Schork, NJ | 1 |
| Ziegler, MG | 1 |
| O'Connor, DT | 1 |
| Wojciechowska, W | 1 |
| Staessen, JA | 1 |
| Stolarz, K | 1 |
| Nawrot, T | 1 |
| Filipovský, J | 1 |
| Tichá, M | 1 |
| Bianchi, G | 2 |
| Brand, E | 1 |
| Cwynar, M | 1 |
| Grodzicki, T | 1 |
| Kuznetsova, T | 1 |
| Struijker-Boudier, HA | 1 |
| Svobodová, V | 1 |
| Thijs, L | 1 |
| Van Bortel, LM | 1 |
| Kawecka-Jaszcz, K | 1 |
| Renner, W | 1 |
| Grammer, T | 1 |
| Hoffmann, MM | 1 |
| Nauck, MS | 1 |
| Winkelmann, BR | 1 |
| Boehm, BO | 1 |
| März, W | 1 |
| Jeng, JR | 1 |
| Wang, JH | 1 |
| Liu, WS | 1 |
| Chen, SP | 1 |
| Chen, MY | 1 |
| Wu, MH | 1 |
| Hsu, WL | 1 |
| Lin, SZ | 1 |
| Chen, M | 1 |
| Yuan, Z | 1 |
| Shan, K | 1 |
| Semplicini, A | 1 |
| Lenzini, L | 1 |
| Sartori, M | 1 |
| Papparella, I | 1 |
| Calò, LA | 1 |
| Pagnin, E | 1 |
| Strapazzon, G | 1 |
| Benna, C | 1 |
| Costa, R | 1 |
| Avogaro, A | 1 |
| Ceolotto, G | 1 |
| Pessina, AC | 1 |
| Rubattu, S | 1 |
| Bigatti, G | 1 |
| Evangelista, A | 1 |
| Lanzani, C | 1 |
| Stanzione, R | 1 |
| Zagato, L | 1 |
| Manunta, P | 1 |
| Marchitti, S | 1 |
| Venturelli, V | 1 |
| Volpe, M | 1 |
| Stella, P | 1 |
| Sookoian, S | 1 |
| Gianotti, TF | 1 |
| González, CD | 1 |
| Pirola, CJ | 1 |
| Kamide, K | 1 |
| Kokubo, Y | 1 |
| Matayoshi, T | 1 |
| Inamoto, N | 1 |
| Takiuchi, S | 1 |
| Horio, T | 1 |
| Miwa, Y | 1 |
| Yoshii, M | 1 |
| Tomoike, H | 1 |
| Tanaka, C | 1 |
| Banno, M | 1 |
| Okuda, T | 1 |
| Kawano, Y | 1 |
| Miyata, T | 1 |
| Velez, DR | 1 |
| Guruju, M | 1 |
| Vinukonda, G | 1 |
| Prater, A | 1 |
| Kumar, A | 1 |
| Williams, SM | 1 |
| Markan, S | 1 |
| Sachdeva, M | 1 |
| Sehrawat, BS | 1 |
| Kumari, S | 1 |
| Jain, S | 1 |
| Khullar, M | 1 |
| Qian, X | 1 |
| Lu, Z | 1 |
| Tan, M | 1 |
| Liu, H | 1 |
| Lu, D | 1 |
| Hu, BC | 1 |
| Chu, SL | 1 |
| Wang, GL | 1 |
| Gao, PJ | 1 |
| Zhu, DL | 1 |
| Wang, JG | 1 |
| Jackson, SN | 1 |
| Williams, B | 1 |
| Houtman, P | 1 |
| Trembath, RC | 1 |
| Inoue, T | 1 |
| Okauchi, Y | 1 |
| Matsuzaki, Y | 1 |
| Kuwajima, K | 1 |
| Kondo, H | 1 |
| Horiuchi, N | 1 |
| Nakao, K | 1 |
| Iwata, M | 1 |
| Yokogoshi, Y | 1 |
| Shintani, Y | 1 |
| Bando, H | 1 |
| Saito, S | 1 |
| Zdrojewicz, Z | 1 |
| Sztuka-Pietkiewicz, A | 1 |
| Revilla, M | 1 |
| Obach, V | 1 |
| Cervera, A | 1 |
| Dávalos, A | 1 |
| Castillo, J | 1 |
| Chamorro, A | 1 |
| Yokota, H | 1 |
| Hashimoto, Y | 1 |
| Okubo, S | 1 |
| Yumoto, M | 1 |
| Mashige, F | 1 |
| Kawamura, M | 1 |
| Kotani, K | 1 |
| Usuki, Y | 1 |
| Shimada, S | 1 |
| Kitamura, K | 1 |
| Nakahara, K | 1 |
| Kurland, L | 1 |
| Melhus, H | 1 |
| Karlsson, J | 1 |
| Kahan, T | 1 |
| Malmqvist, K | 1 |
| Ohman, P | 1 |
| Nyström, F | 1 |
| Hägg, A | 1 |
| Lind, L | 1 |
| Tay, CH | 1 |
| Chew, WL | 1 |
| Lim, LC | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Physiological and Psychological Effects of Testosterone During Severe Energy Deficit and Recovery: a Randomized, Placebo Controlled Trial[NCT02734238] | Phase 4 | 53 participants (Actual) | Interventional | 2016-04-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Height was measured using a stadiometer. Weight was measured using a calibrated digital scale. Body composition was determined using dual-energy X-ray absorptiometry. These data were used to calculate fat-free body mass, fat mass, and total body tissue mass. (NCT02734238)
Timeframe: end of each study phase: Day 11 for Phase 1, Day 39 for Phase 2, up to Day 85 for Phase 3
| Intervention | kilograms (Least Squares Mean) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Total Body Mass at end of Phase 1 | Total Body Mass at end of Phase 2 | Total Body Mass at end of Phase 3 | Fat-free Mass at end of Phase 1 | Fat-free Mass at end of Phase 2 | Fat-free Mass at end of Phase 3 | Fat Mass at end of Phase 1 | Fat Mass at end of Phase 2 | Fat Mass at end of Phase 3 | |
| Energy Deficit | 78.3 | 73.3 | 76.5 | 58.3 | 58.0 | 60.5 | 16.8 | 12.2 | 12.8 |
| Energy Deficit + Testosterone | 78.0 | 75.8 | 79.3 | 57.9 | 60.4 | 63.1 | 16.8 | 12.0 | 12.8 |
5 reviews available for cytosine and Hypertension
| Article | Year |
|---|---|
Association between aldosterone synthase CYP11B2 polymorphism and essential hypertension in Chinese: a meta-analysis.
Topics: Asian People; Cytochrome P-450 CYP11B2; Cytosine; Humans; Hypertension; Polymorphism, Genetic; Promo | 2009 |
Association of the C-344T aldosterone synthase gene variant with essential hypertension: a meta-analysis.
Topics: Aldosterone; Blood Pressure; Case-Control Studies; Cohort Studies; Cross-Sectional Studies; Cytochro | 2007 |
A meta-analysis of association between C677T polymorphism in the methylenetetrahydrofolate reductase gene and hypertension.
Topics: Asian People; Bias; Cytosine; Genetic Predisposition to Disease; Heterozygote; Humans; Hypertension; | 2007 |
Identification of a single cytosine base insertion mutation at Arg-597 of the beta subunit of the human epithelial sodium channel in a family with Liddle's disease.
Topics: Adolescent; Adult; Amino Acid Sequence; Amino Acid Substitution; Arginine; Base Sequence; Cytosine; | 1998 |
[The role of beta 3-adrenergic receptors in the human organism].
Topics: Arginine; Coronary Disease; Cytosine; Diabetes Mellitus; Energy Metabolism; Humans; Hypertension; Li | 2001 |
3 trials available for cytosine and Hypertension
| Article | Year |
|---|---|
Association of angiotensin II type 2 receptor gene variant with hypertension.
Topics: Adenine; Adult; Asian People; Blood Pressure; Cytosine; Female; Genetic Variation; Genotype; Humans; | 2003 |
MTHFR 677 CT/MTHFR 1298 CC genotypes are associated with increased risk of hypertension in Indians.
Topics: Asian People; Case-Control Studies; Cytosine; Female; Folic Acid; Gene Frequency; Genetic Predisposi | 2007 |
Aldosterone synthase (CYP11B2) -344 C/T polymorphism is related to antihypertensive response: result from the Swedish Irbesartan Left Ventricular Hypertrophy Investigation versus Atenolol (SILVHIA) trial.
Topics: Adrenergic beta-Antagonists; Aldosterone; Angiotensin Receptor Antagonists; Antihypertensive Agents; | 2002 |
22 other studies available for cytosine and Hypertension
| Article | Year |
|---|---|
Base-resolution maps of 5-methylcytosine and 5-hydroxymethylcytosine in Dahl S rats: effect of salt and genomic sequence.
Topics: 5-Methylcytosine; Animals; Base Sequence; CpG Islands; Cytosine; Disease Models, Animal; Epigenomics | 2014 |
Molecular characterization of a Chinese family carrying a novel C4329A mutation in mitochondrial tRNAIle and tRNAGln genes.
Topics: Asian People; Case-Control Studies; Cytosine; DNA, Mitochondrial; Female; Genetic Predisposition to | 2014 |
Adenine/cytosine(1166) polymorphism of the angiotensin II type 1 receptor gene and the antihypertensive response to angiotensin-converting enzyme inhibitors.
Topics: Adenosine; Angiotensin-Converting Enzyme Inhibitors; Cohort Studies; Cytosine; Humans; Hypertension; | 2009 |
Coronary heart disease and chronic periodontitis: is polymorphism of interleukin-6 gene the common risk factor in a Chinese population?
Topics: Adenine; Adult; Aged; Alcohol Drinking; Case-Control Studies; China; Chromosome Mapping; Chronic Per | 2011 |
Genetic association study between Interleukin 10 gene and dental implant loss.
Topics: Adenine; Alleles; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Cardiovascular | 2012 |
Matrix analysis for the dissection of interactions of G-protein beta3 subunit C825T genotype, allograft function, and posttransplant hypertension in kidney transplantation.
Topics: Adult; Cytosine; Female; Follow-Up Studies; Genotype; Graft Survival; Heterotrimeric GTP-Binding Pro | 2002 |
The A1166C polymorphism of the AT1 receptor gene is associated with collagen type I synthesis and myocardial stiffness in hypertensives.
Topics: Adenine; Adult; Aged; Alleles; Antihypertensive Agents; Atenolol; Collagen Type I; Cytosine; Elastic | 2003 |
Association between the interleukin-1beta C(-511)T polymorphism and blood pressure in a Chinese hypertensive population.
Topics: Asian People; Blood Pressure; Cytosine; Female; Genetic Predisposition to Disease; Humans; Hypertens | 2004 |
Functional allelic heterogeneity and pleiotropy of a repeat polymorphism in tyrosine hydroxylase: prediction of catecholamines and response to stress in twins.
Topics: Adenine; Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Alleles; Autonomic Nervous System; | 2004 |
Association of peripheral and central arterial wave reflections with the CYP11B2 -344C allele and sodium excretion.
Topics: Adult; Alleles; Arteries; Blood Pressure; Cytochrome P-450 CYP11B2; Cytosine; DNA Transposable Eleme | 2004 |
Association analysis of the polymorphism T1128C in the signal peptide of neuropeptide Y in a Swedish hypertensive population.
Topics: Cytosine; Humans; Hypertension; Neuropeptide Y; Polymorphism, Genetic; Protein Sorting Signals; Swed | 2004 |
Association of interleukin-6 gene G-174C polymorphism and plasma plasminogen activator inhibitor-1 level in Chinese patients with and without hypertension.
Topics: Adult; Asian People; Case-Control Studies; Cytosine; Female; Gene Frequency; Genotype; Guanine; Huma | 2005 |
Association of apolipoprotein J gene 866C-->T polymorphism with preeclampsia and essential hypertension.
Topics: Adult; Amino Acid Sequence; Case-Control Studies; China; Clusterin; Cytosine; DNA Mutational Analysi | 2005 |
Reduced expression of regulator of G-protein signaling 2 (RGS2) in hypertensive patients increases calcium mobilization and ERK1/2 phosphorylation induced by angiotensin II.
Topics: Adult; Angiotensin II; Calcium; Cells, Cultured; Cytosine; Extracellular Signal-Regulated MAP Kinase | 2006 |
Association of atrial natriuretic peptide and type a natriuretic peptide receptor gene polymorphisms with left ventricular mass in human essential hypertension.
Topics: Adenine; Adult; Alleles; Atrial Natriuretic Factor; Cytosine; Echocardiography; Female; Genetic Vari | 2006 |
Association of genetic polymorphisms of ACADSB and COMT with human hypertension.
Topics: Acyl-CoA Dehydrogenases; Adenine; Aged; Asian People; Blood Pressure; Cohort Studies; Cytosine; DNA- | 2007 |
Angiotensinogen promoter sequence variants in essential hypertension.
Topics: Adenine; Angiotensinogen; Black or African American; Cohort Studies; Cytosine; Female; Gene Frequenc | 2006 |
Association between genetic variation in transforming growth factors beta1 and beta3 and renal dysfunction in non-diabetic Chinese.
Topics: Adenine; Adult; Aged; Aged, 80 and over; Albuminuria; Asian People; Creatinine; Cytosine; Female; Ge | 2008 |
The diagnosis of Liddle syndrome by identification of a mutation in the beta subunit of the epithelial sodium channel.
Topics: Aldosterone; Alleles; Amino Acid Sequence; Base Sequence; Blood Pressure; Chromosome Mapping; Chromo | 1998 |
A -174G/C polymorphism of the interleukin-6 gene in patients with lacunar infarction.
Topics: Aged; Brain; Brain Ischemia; Cerebral Infarction; Cohort Studies; Cytosine; Diabetes Complications; | 2002 |
Apolipoprotein A-I deficiency with accumulated risk for CHD but no symptoms of CHD.
Topics: Aged; Amino Acid Sequence; Apolipoprotein A-I; Apolipoproteins E; Base Sequence; Cholesterol, HDL; C | 2002 |
Cryptococcal meningitis: its apparent increased incidence in the Far East.
Topics: Adolescent; Adult; Amphotericin B; Animals; Asian People; Cerebrospinal Fluid Proteins; Child; Colum | 1972 |