cytosine has been researched along with Head and Neck Neoplasms in 11 studies
Head and Neck Neoplasms: Soft tissue tumors or cancer arising from the mucosal surfaces of the LIP; oral cavity; PHARYNX; LARYNX; and cervical esophagus. Other sites included are the NOSE and PARANASAL SINUSES; SALIVARY GLANDS; THYROID GLAND and PARATHYROID GLANDS; and MELANOMA and non-melanoma skin cancers of the head and neck. (from Holland et al., Cancer Medicine, 4th ed, p1651)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Human papillomavirus (HPV) causes cervical cancer and a large fraction of head and neck squamous cell carcinomas (HNSCC)." | 1.43 | Cidofovir is active against human papillomavirus positive and negative head and neck and cervical tumor cells by causing DNA damage as one of its working mechanisms. ( Andrei, G; Mertens, B; Naesens, L; Nogueira, T; Snoeck, R; Stranska, R, 2016) |
| "As expected, HPV- HNSCC displays a smoking-associated mutational signature, whereas our data suggest that reduced exposure to exogenous carcinogens in HPV+ HNSCC creates a selective pressure that favors emergence of tumors with APOBEC-mediated driver mutations." | 1.40 | APOBEC-mediated cytosine deamination links PIK3CA helical domain mutations to human papillomavirus-driven tumor development. ( Boshoff, C; Chakravarthy, A; Fenton, TR; Henderson, S; Su, X, 2014) |
| "203 head and neck cancer patients and 201 healthy controls were genotyped for functional polymorphisms of CYP2A13 and UGT1A7 genes using polymerase chain reaction-restriction fragment length polymorphism, denaturing high-performance liquid chromatography and sequencing." | 1.36 | Polymorphisms in CYP2A13 and UGT1A7 genes and head and neck cancer susceptibility in North Indians. ( Ahuja, M; Khullar, M; Panda, N; Sharma, R, 2010) |
| "Microsatellite instability was detected in nine cases in both procedures." | 1.34 | Shorter CAG repeat length in the AR gene is associated with poor outcome in head and neck cancer. ( Canevari, Rde A; dos Santos, RM; Kowalski, LP; Magrin, J; Nishimoto, IN; Poli-Frederico, RC; Rainho, CA; Rogatto, SR; Rosa, FE, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (9.09) | 18.2507 |
| 2000's | 3 (27.27) | 29.6817 |
| 2010's | 7 (63.64) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Niu, Y | 1 |
| Yuan, H | 1 |
| Shen, M | 1 |
| Li, H | 1 |
| Hu, Y | 1 |
| Chen, N | 1 |
| Henderson, S | 1 |
| Chakravarthy, A | 1 |
| Su, X | 1 |
| Boshoff, C | 1 |
| Fenton, TR | 1 |
| Zeitels, SM | 1 |
| Mertens, B | 1 |
| Nogueira, T | 1 |
| Stranska, R | 1 |
| Naesens, L | 1 |
| Andrei, G | 1 |
| Snoeck, R | 1 |
| Sharma, R | 2 |
| Ahuja, M | 1 |
| Panda, N | 1 |
| Khullar, M | 2 |
| Panda, NK | 1 |
| Tjon Pian Gi, RE | 1 |
| Ilmarinen, T | 1 |
| van den Heuvel, ER | 1 |
| Aaltonen, LM | 1 |
| Andersen, J | 1 |
| Brunings, JW | 1 |
| Chirila, M | 1 |
| Dietz, A | 1 |
| Ferran Vilà, F | 1 |
| Friedrich, G | 1 |
| de Gier, HH | 1 |
| Golusinski, W | 1 |
| Graupp, M | 1 |
| Hantzakos, A | 1 |
| Horcasitas, R | 1 |
| Jackowska, J | 1 |
| Koelmel, JC | 1 |
| Lawson, G | 1 |
| Lindner, F | 1 |
| Remacle, M | 1 |
| Sittel, C | 1 |
| Weichbold, V | 1 |
| Wierzbicka, M | 1 |
| Dikkers, FG | 1 |
| Sirianni, N | 1 |
| Wang, J | 1 |
| Ferris, RL | 1 |
| Rosa, FE | 1 |
| dos Santos, RM | 1 |
| Poli-Frederico, RC | 1 |
| Canevari, Rde A | 1 |
| Nishimoto, IN | 1 |
| Magrin, J | 1 |
| Rainho, CA | 1 |
| Kowalski, LP | 1 |
| Rogatto, SR | 1 |
| Merlo, A | 1 |
| Herman, JG | 1 |
| Mao, L | 1 |
| Lee, DJ | 1 |
| Gabrielson, E | 1 |
| Burger, PC | 1 |
| Baylin, SB | 1 |
| Sidransky, D | 1 |
| Abdulkarim, B | 1 |
| Sabri, S | 1 |
| Deutsch, E | 1 |
| Chagraoui, H | 1 |
| Maggiorella, L | 1 |
| Thierry, J | 1 |
| Eschwege, F | 1 |
| Vainchenker, W | 1 |
| Chouaïb, S | 1 |
| Bourhis, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Efficacy and Safety Assessment of Oral LBH589 in Adult Patients With Advanced Soft Tissue Sarcoma After Pre-treatment Failure: an Open-label, Multicenter Phase II Study[NCT01136499] | Phase 2 | 53 participants (Actual) | Interventional | 2010-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
11 other studies available for cytosine and Head and Neck Neoplasms
| Article | Year |
|---|---|
Association between cyclooxygenase-2 gene polymorphisms and head and neck squamous cell carcinoma risk.
Topics: 3' Untranslated Regions; Adenine; Adult; Aged; Alcohol Drinking; Carcinoma, Squamous Cell; Case-Cont | 2014 |
APOBEC-mediated cytosine deamination links PIK3CA helical domain mutations to human papillomavirus-driven tumor development.
Topics: Carcinoma, Squamous Cell; Cell Transformation, Viral; Class I Phosphatidylinositol 3-Kinases; Cytidi | 2014 |
Glottic Cancer: A Metamorphosing Disease.
Topics: Adolescent; Adult; Antiviral Agents; Carcinoma, Squamous Cell; Cidofovir; Cytosine; Diagnostic Error | 2016 |
Cidofovir is active against human papillomavirus positive and negative head and neck and cervical tumor cells by causing DNA damage as one of its working mechanisms.
Topics: Antiviral Agents; Carcinoma, Squamous Cell; Cell Line, Tumor; Cidofovir; Cytosine; DNA Damage; Femal | 2016 |
Polymorphisms in CYP2A13 and UGT1A7 genes and head and neck cancer susceptibility in North Indians.
Topics: Alcohol Drinking; Aryl Hydrocarbon Hydroxylases; Carcinogens; Chromatography, High Pressure Liquid; | 2010 |
Hypermethylation of carcinogen metabolism genes, CYP1A1, CYP2A13 and GSTM1 genes in head and neck cancer.
Topics: Adenine; Alcohol Drinking; Aryl Hydrocarbon Hydroxylases; Carcinogens; Carcinoma, Squamous Cell; CpG | 2010 |
Safety of intralesional cidofovir in patients with recurrent respiratory papillomatosis: an international retrospective study on 635 RRP patients.
Topics: Antiviral Agents; Cidofovir; Combined Modality Therapy; Cytosine; Female; Head and Neck Neoplasms; H | 2013 |
Antiviral activity of Cidofovir on a naturally human papillomavirus-16 infected squamous cell carcinoma of the head and neck (SCCHN) cell line improves radiation sensitivity.
Topics: Adult; Antiviral Agents; Blotting, Western; Carcinoma, Squamous Cell; Cell Survival; Cidofovir; Cyto | 2005 |
Shorter CAG repeat length in the AR gene is associated with poor outcome in head and neck cancer.
Topics: Adenine; Adolescent; Adult; Aged; Aged, 80 and over; Alleles; Case-Control Studies; Cytosine; Diseas | 2007 |
5' CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers.
Topics: 5-Methylcytosine; Alleles; Azacitidine; Base Sequence; Brain Neoplasms; Carcinoma, Non-Small-Cell Lu | 1995 |
Antiviral agent Cidofovir restores p53 function and enhances the radiosensitivity in HPV-associated cancers.
Topics: Animals; Antiviral Agents; Carcinoma; Cell Division; Cidofovir; Cyclin A; Cyclin-Dependent Kinase In | 2002 |