cytosine and Genetic Predisposition studies

Research Excerpts

Excerpt	Relevance	Reference
"This review assesses the associations of interleukin-8 gene (IL-8) -251A/T (rs4073) and -845T/C (rs2227532) polymorphisms with susceptibility to periodontitis."	8.91	Quantitative assessment of the associations between interleukin-8 polymorphisms and periodontitis susceptibility. ( Chen, X; Ding, C; Huang, J; Zhong, L, 2015)
"To investigate the association between the androgen receptor (AR) cytosine, adenine, and guanine (CAG) repeat polymorphisms and endometriosis."	7.85	Androgen receptor cytosine, adenine, and guanine trinucleotide repeat polymorphism in Korean patients with endometriosis: A case-control study. ( Chae, SJ; Choi, HY; Choi, YM; Hwang, K; Kim, JJ; Kim, JM; Lee, GH; Shin, JJ, 2017)
"Weight gain, leading to further morbidity and poor treatment compliance, is a common consequence of treatment with clozapine."	7.73	Polymorphism of the adrenergic receptor alpha 2a -1291C>G genetic variation and clozapine-induced weight gain. ( Bai, YM; Chen, JY; Lai, IC; Lin, CC; Liou, YJ; Wang, YC, 2005)
"The angiotensinogen (AGT) gene has been implicated as a risk factor in essential hypertension."	5.33	Angiotensinogen promoter sequence variants in essential hypertension. ( Guruju, M; Kumar, A; Prater, A; Velez, DR; Vinukonda, G; Williams, SM, 2006)
"Endometriosis was documented in 105 women (stage I-II in 33 women and stage III-IV in 72 women)."	5.32	Androgen receptor gene cytosine, adenine, and guanine trinucleotide repeats in patients with endometriosis. ( Di Blasio, AM; Lattuada, D; Odorizzi, MP; Somigliana, E; Viganò, P; Vignali, M, 2004)
"This review assesses the associations of interleukin-8 gene (IL-8) -251A/T (rs4073) and -845T/C (rs2227532) polymorphisms with susceptibility to periodontitis."	4.91	Quantitative assessment of the associations between interleukin-8 polymorphisms and periodontitis susceptibility. ( Chen, X; Ding, C; Huang, J; Zhong, L, 2015)
"To investigate the association between the androgen receptor (AR) cytosine, adenine, and guanine (CAG) repeat polymorphisms and endometriosis."	3.85	Androgen receptor cytosine, adenine, and guanine trinucleotide repeat polymorphism in Korean patients with endometriosis: A case-control study. ( Chae, SJ; Choi, HY; Choi, YM; Hwang, K; Kim, JJ; Kim, JM; Lee, GH; Shin, JJ, 2017)
"We investigated whether the C1245G polymorphism of human 8-oxoguanine glycosylase 1 (hOGG1) gene confers the susceptibility to systemic lupus erythematosus (SLE) occurrence of lupus nephritis and affects the plasma level of 8-hydroxy-2'-deoxyguanosine (8-OHdG) in patients with SLE."	3.81	The role of hOGG1 C1245G polymorphism in the susceptibility to lupus nephritis and modulation of the plasma 8-OHdG in patients with systemic lupus erythematosus. ( Lee, CS; Lee, HT; Lin, CS; Tsai, CY; Wei, YH, 2015)
" The simultaneous detection of 5-methylcytosine and 5-hydroxymethylcytosine is likely to stimulate the discovery of aberrantly methylated genes with increased accuracy in human hepatocellular carcinoma."	3.80	Integrated analyses of DNA methylation and hydroxymethylation reveal tumor suppressive roles of ECM1, ATF5, and EOMES in human hepatocellular carcinoma. ( Gao, F; Huang, J; Lin, Z; Liu, W; Liu, X; Luo, H; Ou, Y; Wang, J; Wen, B; Xia, Y; Zhang, X; Zhou, B, 2014)
"Recent advances in schizophrenia (SZ) research indicate that the telencephalic gamma-aminobutyric acid (GABA)ergic neurotransmission deficit associated with this psychiatric disorder probably is mediated by the hypermethylation of the glutamic acid decarboxylase 67 (GAD(67)), reelin and other GABAergic promoters."	3.75	Characterization of the action of antipsychotic subtypes on valproate-induced chromatin remodeling. ( Costa, E; Dong, E; Grayson, DR; Guidotti, A; Kundakovic, M; Satta, R, 2009)
"Weight gain, leading to further morbidity and poor treatment compliance, is a common consequence of treatment with clozapine."	3.73	Polymorphism of the adrenergic receptor alpha 2a -1291C>G genetic variation and clozapine-induced weight gain. ( Bai, YM; Chen, JY; Lai, IC; Lin, CC; Liou, YJ; Wang, YC, 2005)
" Our results suggest that the combined effect of elevations in maternal homocysteine, smoking, and the MTHFR 677 C>T polymorphism increase the risk of having a CHD-affected pregnancy."	3.73	Congenital heart defects, maternal homocysteine, smoking, and the 677 C>T polymorphism in the methylenetetrahydrofolate reductase gene: evaluating gene-environment interactions. ( Cleves, MA; Hobbs, CA; James, SJ; Jernigan, S; Lu, Y; Malik, S; Melnyk, S, 2006)
"The aim of this study was to investigate a possible association among the thermolabile polymorphism, nucleotide 677 cytosine to thymidine point mutation (677 C-->T) of the methylenetetrahydrofolate reductase (MTHFR) gene, hyperhomocysteinemia, serum folate, vitamins B12 and B6, and stroke in children."	3.70	Children with stroke: polymorphism of the MTHFR gene, mild hyperhomocysteinemia, and vitamin status. ( Artuch, R; Campistol, J; Cardo, E; Colomé, C; Monrós, E; Pineda, M; Vilaseca, MA, 2000)
"We genotyped 306 patients with early breast cancer, who were randomised to receive post-operative radiotherapy or CMF chemotherapy, for the RAD51 135G>C polymorphism."	2.80	The RAD51 135G>C polymorphism is related to the effect of adjuvant therapy in early breast cancer. ( Asklid, A; Fornander, T; Söderlund Leifler, K; Stenmark Askmalm, M, 2015)
"Studies on dental caries suggest that in severe cases it may induce a systemic immune response."	2.73	Host and microbiological factors related to dental caries development. ( De Soet, JJ; Laine, ML; Morré, SA; van Amerongen, WE; van Gemert-Schriks, MC; van Winkelhoff, AJ, 2008)
"The overall OR (95% CI) of type 2 diabetes was 0."	2.44	Association between the T-381C polymorphism of the brain natriuretic peptide gene and risk of type 2 diabetes in human populations. ( Amouyel, P; Arveiler, D; Cottel, D; de Groote, P; Ferrières, J; Groves, CJ; Hattersley, AT; Hitman, GA; McCarthy, MI; Meirhaeghe, A; Sandhu, MS; Walker, M; Wareham, NJ, 2007)
"Susceptibility to ME/CFS involves genetic predisposition and exposure to environmental factors, suggesting an epigenetic association."	1.56	Changes in DNA methylation profiles of myalgic encephalomyelitis/chronic fatigue syndrome patients reflect systemic dysfunctions. ( Chatterjee, A; Edgar, CD; Helliwell, AM; Stockwell, PA; Sweetman, EC; Tate, WP, 2020)
"This glycine was located in strand 5B and was well conserved in other serpins."	1.46	Mutation in a highly conserved glycine residue in strand 5B of plasminogen activator inhibitor 1 causes polymerisation. ( Iwaki, T; Kanayama, N; Nagahashi, K; Suzuki-Inoue, K; Takano, K; Umemura, K; Urano, T, 2017)
"Twenty-nine chronic periodontitis patients and 31 healthy controls of North Indian origin from Chhattisgarh were recruited for the study."	1.42	Interleukin 1β (+3954, -511 and -31) polymorphism in chronic periodontitis patients from North India. ( Amirisetty, R; Das, S; Jyothy, A; Munshi, A; Patel, RP; Saraf, J, 2015)
"Meanwhile, we found COPD patients with CC genotype had significantly higher risk for PH (OR = 1."	1.42	A single nucleotide polymorphism in 3' untranslated region of epithelial growth factor receptor confers risk for pulmonary hypertension in chronic obstructive pulmonary disease. ( Fei, L; Li, M; Wang, R; Xu, X; Zeng, D; Zhang, Y; Zhou, S; Zhu, Q, 2015)
"Although chronic periodontitis (CP) is a multifactorial condition, few studies have investigated the potential association of gene variants with the outcome of periodontal therapy."	1.40	Clinical outcomes of periodontal therapy are not influenced by the ATC/TTC haplotype in the IL8 gene. ( Anovazzi, G; Cirelli, JA; Corbi, SC; Finoti, LS; Gerlach, RF; Kim, YJ; Marcaccini, AM; Orrico, SR; Scarel-Caminaga, RM; Secolin, R; Tanaka, MH, 2014)
"Hypertension is a very common cardiovascular disease influenced by multiple genetic and environmental factors."	1.40	Molecular characterization of a Chinese family carrying a novel C4329A mutation in mitochondrial tRNAIle and tRNAGln genes. ( Chen, Y; Gao, J; Guan, M; Lan, Y; Li, Y; Li, Z; Liu, Y; Yang, J; Zhu, C, 2014)
"Sjogren's syndrome is characterized by T-cell infiltration of exocrine glands leading to parenchymal destruction and impaired glandular function."	1.40	Th1 and Th2 polymorphisms in Sjögren's syndrome and rheumatoid arthritis. ( de Albuquerque Tavares Carvalho, A; de Souza, TR; Duarte, ÂP; Gueiros, LA; Leão, JC; Porter, SR, 2014)
"A case-control study of 206 breast cancer patients and 262 controls was conducted in Iranian women."	1.39	Polymorphic CT dinucleotide repeat in the GATA3 gene and risk of breast cancer in Iranian women. ( Forousan, S; Manoochehr, T; Simin, H; Zakieh, A, 2013)
"Coronary heart disease (CHD) and chronic periodontitis (CP) both are multifactorial chronic diseases and related to inflammation."	1.37	Coronary heart disease and chronic periodontitis: is polymorphism of interleukin-6 gene the common risk factor in a Chinese population? ( Fan, WH; Liu, DL; Sun, SY; Xiao, LM; Xie, CJ; Zhang, JC, 2011)
"One-hundred and fourteen patients with chronic periodontitis and 77 periodontally healthy subjects were genotyped using TaqMan® allelic discrimination assays."	1.37	Single nucleotide polymorphisms of pattern recognition receptors and chronic periodontitis. ( De Nardin, E; Genco, RJ; Gunsolley, J; Sahingur, SE; Schenkein, HA; Xia, XJ, 2011)
"Tobacco-related oral squamous cell carcinoma (OSCC) is one of the most common cancers involving Indian males."	1.37	Functional variants of IL4 and IL6 genes and risk of tobacco-related oral carcinoma in high-risk Asian Indians. ( Das, S; Gaur, P; Mittal, M; Mohanti, B, 2011)
"203 head and neck cancer patients and 201 healthy controls were genotyped for functional polymorphisms of CYP2A13 and UGT1A7 genes using polymerase chain reaction-restriction fragment length polymorphism, denaturing high-performance liquid chromatography and sequencing."	1.36	Polymorphisms in CYP2A13 and UGT1A7 genes and head and neck cancer susceptibility in North Indians. ( Ahuja, M; Khullar, M; Panda, N; Sharma, R, 2010)
"Two families with frontotemporal dementia with parkinsonism linked to chromosome 17 (FTDP-17) resulting from the microtubule associated protein tau (MAPT) gene IVS10+16C>T splice site mutation are reported, members of which showed variable clinical phenotypes at presentation."	1.35	Intrafamilial clinical phenotypic heterogeneity with MAPT gene splice site IVS10+16C>T mutation. ( Larner, AJ, 2009)
"Periodontitis is a multifactorial disease in which environmental and genetic determinant factors contribute to individual subjects susceptibility."	1.35	E-selectin and L-selectin polymorphisms in patients with periodontitis. ( Gholami, L; Hajilooi, M; Houshmand, B; Mani-Kashani, K; Rafiei, A, 2009)
"Little is known about the influence of genetic susceptibility on implant loss."	1.35	Analysis of the association of IL1B (C+3954T) and IL1RN (intron 2) polymorphisms with dental implant loss in a Brazilian population. ( Alvim-Pereira, F; de Castilhos, BB; Montes, CC; Olandoski, M; Sakurai, ML; Trevilatto, PC, 2009)
"Endometriosis is a common gynaecological disorder due to ectopic implantation of endometrial tissue."	1.35	PTPN22/LYP 1858C>T gene polymorphism and susceptibility to endometriosis in a Polish population. ( Barcz, E; Dziunycz, P; Kamiński, P; Kostrzewa, G; Malejczyk, J; Milewski, Ł; Płoski, R; Roszkowski, PI; Zabek, J, 2009)
"The discrimination of nonalcoholic steatohepatitis (NASH) from another NAFLD was made by NAFLD activity score (NAS), and a NAS>or=5 was considered NASH."	1.34	Methylenetetrahydrofolate reductase C677T mutation and nonalcoholic fatty liver disease. ( Ataç, FB; Bilezikçi, B; Güçlü, M; Kayaselçuk, F; Ozer, B; Serin, E; Verdi, H; Yilmaz, U, 2007)
"The etiology of preeclampsia (PE) is unknown, but endothelial cell injury plays a pivotal role."	1.33	Association of apolipoprotein J gene 866C-->T polymorphism with preeclampsia and essential hypertension. ( Chen, M; Shan, K; Yuan, Z, 2005)
"42."	1.33	Association of mitochondrial deoxyribonucleic acid 16189 variant (T->C transition) with metabolic syndrome in Chinese adults. ( Chen, IY; Chen, JF; Chen, MH; Chen, SD; Eng, HL; Lee, CF; Lin, TK; Liou, CW; Liu, RT; Wang, PW; Wei, YH; Weng, SW, 2005)
"Comparing women with uterine leiomyomas and controls, no statistically significant differences with respect to allele frequency and genotype distribution were ascertained for ESR1 IVS 1-397 T/C (PvuII) (P=0."	1.33	Genotype distribution of estrogen receptor-alpha, catechol-O-methyltransferase, and cytochrome P450 17 gene polymorphisms in Caucasian women with uterine leiomyomas. ( Bentz, EK; Denschlag, D; Hefler, L; Pietrowski, D; Tempfer, C; Tong, D; Zeillinger, R, 2006)
"The angiotensinogen (AGT) gene has been implicated as a risk factor in essential hypertension."	1.33	Angiotensinogen promoter sequence variants in essential hypertension. ( Guruju, M; Kumar, A; Prater, A; Velez, DR; Vinukonda, G; Williams, SM, 2006)
"The age-adjusted RR of all cancers in homozygotes relative to non-carriers was 1."	1.32	Integrin beta3 Leu33Pro homozygosity and risk of cancer. ( Bojesen, SE; Nordestgaard, BG; Tybjaerg-Hansen, A, 2003)
"Endometriosis was documented in 105 women (stage I-II in 33 women and stage III-IV in 72 women)."	1.32	Androgen receptor gene cytosine, adenine, and guanine trinucleotide repeats in patients with endometriosis. ( Di Blasio, AM; Lattuada, D; Odorizzi, MP; Somigliana, E; Viganò, P; Vignali, M, 2004)
"Lymphocyte genomic DNA from 134 Italian gastric cancer patients and 139 controls was used for genotyping two polymorphisms in the TS 5'-untranslated region (5'-UTR); a double (2R) or triple (3R) 28-bp repeat and a G/C polymorphism within the triple repeats allele (3G allele)."	1.32	Association of thymidylate synthase polymorphisms with gastric cancer susceptibility. ( Bearzi, I; Cascinu, S; Catalano, V; Ficarelli, R; Graziano, F; Humar, B; Kawakami, K; Magnani, M; Merriman, T; Panunzi, S; Ruzzo, A; Santini, D; Testa, E; Tonini, G; Watanabe, G, 2004)
"Type 1 diabetes is an autoimmune disease with a Th1 phenotype in which insulin-producing beta-cells in the pancreas are destroyed."	1.32	A polymorphism in the TCF7 gene, C883A, is associated with type 1 diabetes. ( Aud, D; Erlich, HA; Grupe, A; Lazzeroni, LC; Mirel, DB; Noble, JA; Peltz, G; Reynolds, R; Valdes, AM; White, AM, 2003)
"Second, tumors occurring in homozygous carriers of the methionine synthase 2756G allele show a lower number of hypermethylated CpG islands of tumor suppressor genes (P = 0."	1.31	Germ-line variants in methyl-group metabolism genes and susceptibility to DNA methylation in normal tissues and human primary tumors. ( Avila, S; Capella, G; Esteller, M; Fraga, MF; Herman, JG; Paz, MF; Peinado, MA; Pollan, M; Sanchez-Cespedes, M, 2002)
"Crohn's disease is a chronic inflammatory disorder of the gastrointestinal tract, which is thought to result from the effect of environmental factors in a genetically predisposed host."	1.31	A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. ( Achkar, JP; Bayless, TM; Bonen, DK; Brant, SR; Britton, H; Chen, FF; Cho, JH; Duerr, RH; Hanauer, SB; Inohara, N; Karaliuskas, R; Kirschner, BS; Moran, T; Nicolae, DL; Nuñez, G; Ogura, Y; Ramos, R, 2001)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	2 (1.14)	18.2507
2000's	109 (62.29)	29.6817
2010's	62 (35.43)	24.3611
2020's	2 (1.14)	2.80

Authors	Studies
Weng, N	1
Miller, M	1
Pham, AK	1
Komor, AC	1
Broide, DH	1
Helliwell, AM	1
Sweetman, EC	1
Stockwell, PA	1
Edgar, CD	1
Chatterjee, A	1
Tate, WP	1
Shin, JJ	1
Choi, YM	1
Choi, HY	1
Chae, SJ	1
Hwang, K	1
Kim, JJ	1
Lee, GH	1
Kim, JM	1
Qiu, C	1
Hanson, RL	1
Fufaa, G	1
Kobes, S	1
Gluck, C	1
Huang, J	3
Chen, Y	2
Raj, D	1
Nelson, RG	1
Knowler, WC	1
Susztak, K	1
Chao, XL	1
Wang, LL	1
Liu, R	1
Li, Y	2
Zhou, XJ	1
Zakieh, A	1
Simin, H	1
Forousan, S	1
Manoochehr, T	1
Mason, EF	1
Hornick, JL	1
Alkhateeb, A	1
Karasneh, J	1
Abbadi, H	1
Hassan, A	1
Thornhill, M	1
Corbi, SC	1
Finoti, LS	2
Anovazzi, G	1
Tanaka, MH	1
Kim, YJ	1
Secolin, R	2
Marcaccini, AM	1
Gerlach, RF	1
Orrico, SR	1
Cirelli, JA	1
Scarel-Caminaga, RM	6
Emingil, G	1
Han, B	1
Gürkan, A	1
Berdeli, A	1
Tervahartiala, T	1
Salo, T	1
Pussinen, PJ	1
Köse, T	1
Atilla, G	2
Sorsa, T	1
de Souza, TR	1
de Albuquerque Tavares Carvalho, A	1
Duarte, ÂP	1
Porter, SR	1
Leão, JC	1
Gueiros, LA	1
Niu, Y	1
Yuan, H	1
Shen, M	1
Li, H	1
Hu, Y	1
Chen, N	1
Alves-Ferreira, M	1
Pinho, T	1
Sousa, A	1
Sequeiros, J	1
Lemos, C	1
Alonso, I	1
Chen, D	1
Zhang, TL	1
Wang, LM	1
Cai, GJ	1
He, GP	1
Huang, ZY	1
Qi, CP	1
Xia, WF	1
Ma, XP	1
Li, XR	1
Dong, H	1
Yi, JL	1
Ding, C	2
Ji, X	1
Chen, X	2
Xu, Y	1
Zhong, L	2
Hazzaa, HH	1
Rashwan, WA	1
Attia, EA	1
Mi, N	1
Hao, Y	1
Jiao, X	2
Zheng, X	2
Song, T	2
Shi, J	2
Dong, C	1
Yan, Y	1
Weng, H	1
Shen, ZH	1
Wu, L	1
Zeng, XT	2
Liu, Y	1
Gao, J	1
Zhu, C	1
Lan, Y	1
Yang, J	2
Li, Z	1
Guan, M	1
Wang, Y	1
Lin, L	1
Xu, H	1
Li, T	1
Zhou, Y	1
Dan, H	1
Jiang, L	1
Liao, G	1
Zhou, M	1
Li, L	1
Zeng, X	1
Li, J	1
Chen, Q	1
Amirisetty, R	1
Patel, RP	1
Das, S	2
Saraf, J	1
Jyothy, A	1
Munshi, A	1
Sakata-Yanagimoto, M	1
Antunes, LS	1
Tannure, PN	1
Antunes, LA	1
Reis, MF	1
Costa, MC	1
Gouvêa, CV	1
Olej, B	1
Granjeiro, JM	1
Küchler, EC	1
Söderlund Leifler, K	1
Asklid, A	1
Fornander, T	1
Stenmark Askmalm, M	1
Gao, F	1
Xia, Y	1
Wang, J	1
Lin, Z	1
Ou, Y	1
Liu, X	1
Liu, W	1
Zhou, B	2
Luo, H	1
Wen, B	1
Zhang, X	2
Su, S	1
Chien, M	1
Lin, C	1
Chen, M	2
Yang, S	1
Mijiti, A	1
Ling, W	1
Moming, A	1
Lee, HT	1
Lin, CS	1
Lee, CS	1
Tsai, CY	1
Wei, YH	2
Liu, DY	1
Kwong, JS	1
Leng, WD	1
Xia, LY	1
Mao, M	1
Wang, XX	1
Sun, BF	1
Jiao, J	1
Chong, ZC	1
Chen, YS	1
Wang, XL	1
Zhao, Y	1
Zhou, YM	1
Li, D	1
Søvik, JB	1
Vieira, AR	1
Tveit, AB	1
Mulic, A	1
Zhou, S	1
Li, M	1
Zeng, D	1
Xu, X	2
Fei, L	1
Zhu, Q	1
Zhang, Y	1
Wang, R	1
Yalcınkaya, M	1
Erbek, SS	1
Babakurban, ST	1
Kupeli, E	1
Bozbas, S	1
Terzi, YK	1
Sahin, FI	1
Pirola, CJ	2
Scian, R	1
Gianotti, TF	2
Dopazo, H	1
Rohr, C	1
Martino, JS	1
Castaño, GO	1
Sookoian, S	2
Liu, FT	1
Zhu, PQ	1
Ou, YX	1
Liu, WW	1
Xia, GF	1
Luo, HL	1
Gok, K	1
Cemeroglu, O	1
Cakirbay, H	1
Gunduz, E	1
Acar, M	1
Cetin, EN	1
Gunduz, M	1
Demircan, K	1
Pang, AP	1
Sugai, C	1
Maunakea, AK	1
Iwaki, T	1
Nagahashi, K	1
Takano, K	1
Suzuki-Inoue, K	1
Kanayama, N	1
Umemura, K	1
Urano, T	1
Reichert, S	1
Machulla, HK	1
Klapproth, J	1
Zimmermann, U	1
Reichert, Y	1
Gläser, C	1
Schaller, HG	1
Schulz, S	1
De Soet, JJ	1
van Gemert-Schriks, MC	1
Laine, ML	2
van Amerongen, WE	1
Morré, SA	2
van Winkelhoff, AJ	2
Holla, LI	2
Fassmann, A	2
Augustin, P	1
Halabala, T	1
Znojil, V	1
Vanek, J	2
Houshmand, B	2
Rafiei, A	2
Hajilooi, M	2
Mani-Kashani, K	1
Gholami, L	1
Murphy, BC	1
O'Reilly, RL	1
Singh, SM	1
Guidotti, A	1
Dong, E	1
Kundakovic, M	1
Satta, R	1
Grayson, DR	1
Costa, E	1
Montes, CC	2
Alvim-Pereira, F	4
de Castilhos, BB	1
Sakurai, ML	1
Olandoski, M	1
Trevilatto, PC	7
Płoski, R	1
Dziunycz, P	1
Kostrzewa, G	1
Roszkowski, PI	1
Barcz, E	1
Zabek, J	1
Milewski, Ł	1
Kamiński, P	1
Malejczyk, J	1
Sfar, I	1
Gorgi, Y	1
Aouadi, H	1
Maklouf, M	1
Ben Romdhane, T	1
Jendoubi-Ayed, S	1
Bardi, R	1
Abderrahim, E	1
Ben Abdallah, T	1
Ayed, K	1
Yan, L	1
Yanan, D	1
Donglan, S	1
Na, W	1
Rongmiao, Z	1
Zhifeng, C	1
Maney, P	1
Walters, JD	1
Larner, AJ	1
López, NJ	1
Valenzuela, CY	1
Jara, L	1
Kobayashi, T	1
Nagata, T	1
Murakami, S	1
Takashiba, S	1
Kurihara, H	1
Izumi, Y	1
Numabe, Y	1
Watanabe, H	1
Kataoka, M	1
Nagai, A	1
Hayashi, J	1
Ohyama, H	1
Okamatsu, Y	1
Inagaki, Y	1
Tai, H	1
Yoshie, H	1
Jianyan, L	1
Zeqiang, G	1
Yongjuan, C	1
Kaihong, D	1
Bing, D	1
Rongsheng, L	1
Huang, SH	1
Chang, PY	1
Liu, CJ	1
Lin, MW	1
Hsia, KT	1
Kitkumthorn, N	2
Yanatatsaneejit, P	1
Rabalert, J	1
Dhammawipark, C	1
Mutirangura, A	1
Sharma, R	1
Ahuja, M	1
Panda, N	1
Khullar, M	2
Nikopensius, T	1
Birnbaum, S	1
Ludwig, KU	1
Jagomägi, T	1
Saag, M	1
Herms, S	1
Knapp, M	1
Hoffmann, P	1
Nöthen, MM	2
Metspalu, A	1
Mangold, E	1
Wu, YM	1
Chuang, HL	1
Ho, YP	1
Ho, KY	1
Tsai, CC	1
Zhang, B	1
Qin, C	1
Cao, F	1
Olinski, R	1
Jurgowiak, M	1
Zaremba, T	1
Jang, JY	1
Park, EK	1
Ryoo, HM	1
Shin, HI	1
Kim, TH	1
Jang, JS	1
Park, HS	1
Choi, JY	1
Kwon, TG	1
Kimkong, I	1
Hirankarn, N	1
Nakkuntod, J	1
Fan, WH	1
Liu, DL	1
Xiao, LM	1
Xie, CJ	1
Sun, SY	1
Zhang, JC	1
Song, Y	2
Zhang, S	1
de Souza Pardo, AP	1
de Brito, RB	2
Alvim-Pereira, CC	2
Probst, CM	1
Garlet, GP	1
Sallum, AW	1
Line, SR	4
Sahingur, SE	1
Xia, XJ	1
Gunsolley, J	1
Schenkein, HA	1
Genco, RJ	1
De Nardin, E	1
Duan, W	1
Xu, J	1
Nie, C	1
Yang, Z	1
Wang, H	1
Wang, W	1
Lu, D	2
Gaur, P	1
Mittal, M	1
Mohanti, B	1
Liu, CM	1
Yeh, CJ	1
Yu, CC	1
Chou, MY	1
Lin, CH	1
Wei, LH	1
Lin, CW	1
Yang, SF	1
Chien, MH	1
Andric, M	1
Nikolic, N	1
Boskovic, M	1
Milicic, B	1
Skodric, S	1
Basta Jovanovic, G	1
Milasin, J	1
Costa-Junior, FR	1
de Souza, AP	2
Santos, MC	1
Pigossi, SC	1
Thude, H	1
Schipler, AD	1
Treszl, A	1
Sterneck, M	1
Nashan, B	1
e Silva, MR	1
Moreira, PR	2
da Costa, GC	1
Saraiva, AM	1
de Souza, PE	1
Amormino, SA	1
da Costa, JE	1
Gollob, KJ	1
Dutra, WO	2
Millar, CB	1
Guy, J	1
Sansom, OJ	1
Selfridge, J	1
MacDougall, E	1
Hendrich, B	1
Keightley, PD	1
Bishop, SM	1
Clarke, AR	1
Bird, A	1
Paz, MF	1
Avila, S	1
Fraga, MF	1
Pollan, M	1
Capella, G	1
Peinado, MA	1
Sanchez-Cespedes, M	1
Herman, JG	1
Esteller, M	1
Steinfath, M	1
Seranski, P	1
Singh, S	1
Fiege, M	1
Wappler, F	1
Schulte Am Esch, J	1
Scholz, J	1
Pola, R	1
Flex, A	1
Gaetani, E	1
Lago, AD	1
Gerardino, L	1
Pola, P	1
Bernabei, R	1
Jenny, NS	1
Tracy, RP	1
Ogg, MS	1
Luong, le A	1
Kuller, LH	1
Arnold, AM	1
Sharrett, AR	1
Humphries, SE	1
Fukasawa, M	1
Matsushita, K	1
Kamiyama, M	1
Mikami, Y	1
Araki, I	1
Yamagata, Z	1
Takeda, M	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Use of Metformin in Prevention and Treatment of Cardiac Fibrosis in PAI-1 Deficient Population[NCT05317806]	Phase 4	15 participants (Anticipated)	Interventional	2022-10-10	Active, not recruiting
[NCT00005692]		0 participants	Observational	1992-04-30	Completed
Physiological and Psychological Effects of Testosterone During Severe Energy Deficit and Recovery: a Randomized, Placebo Controlled Trial[NCT02734238]	Phase 4	53 participants (Actual)	Interventional	2016-04-30	Completed
A Double-blind, Randomized, Placebo-controlled Multicenter Study to Assess the Safety and Efficacy of AST-120 in Mild to Moderately Active Crohn's Patients With Fistulas[NCT00321412]	Phase 3	191 participants (Actual)	Interventional	2006-03-31	Completed
Genetic Markers as Predictors of Phenotypes in Pediatric Onset Crohn's Disease[NCT00783575]		0 participants (Actual)	Observational	2002-10-31	Withdrawn (stopped due to PI has left institution)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Height was measured using a stadiometer. Weight was measured using a calibrated digital scale. Body composition was determined using dual-energy X-ray absorptiometry. These data were used to calculate fat-free body mass, fat mass, and total body tissue mass. (NCT02734238)
Timeframe: end of each study phase: Day 11 for Phase 1, Day 39 for Phase 2, up to Day 85 for Phase 3

Intervention	kilograms (Least Squares Mean)
	Total Body Mass at end of Phase 1	Total Body Mass at end of Phase 2	Total Body Mass at end of Phase 3	Fat-free Mass at end of Phase 1	Fat-free Mass at end of Phase 2	Fat-free Mass at end of Phase 3	Fat Mass at end of Phase 1	Fat Mass at end of Phase 2	Fat Mass at end of Phase 3
Energy Deficit	78.3	73.3	76.5	58.3	58.0	60.5	16.8	12.2	12.8
Energy Deficit + Testosterone	78.0	75.8	79.3	57.9	60.4	63.1	16.8	12.0	12.8

Article	Year
TNF-α gene promoter polymorphisms contribute to periodontitis susceptibility: evidence from 46 studies. Journal of clinical periodontology, 2014, Volume: 41, Issue:8 Topics: Adenine; Cytosine; Genetic Predisposition to Disease; Genotype; Guanine; Humans; Periodontitis; Poly	2014
Association between interleukin-4 gene -590 c/t, -33 c/t, and 70-base-pair polymorphisms and periodontitis susceptibility: a meta-analysis. Journal of periodontology, 2014, Volume: 85, Issue:11 Topics: Alleles; Base Pairing; Cytosine; Genetic Predisposition to Disease; Genetic Variation; Genotype; Hum	2014
[TET2 dysregulation in hematologic malignancies]. [Rinsho ketsueki] The Japanese journal of clinical hematology, 2014, Volume: 55, Issue:10 Topics: Azacitidine; Cytosine; Decitabine; Dioxygenases; DNA-Binding Proteins; Enzyme Inhibitors; Epigenesis	2014
Quantitative assessment of the associations between interleukin-8 polymorphisms and periodontitis susceptibility. Journal of periodontology, 2015, Volume: 86, Issue:2 Topics: Adenine; Asian People; Brazil; Cytosine; Ethnicity; Genetic Predisposition to Disease; Humans; Inter	2015
Meta-Analysis of Association Between Interleukin-1β C-511T Polymorphism and Chronic Periodontitis Susceptibility. Journal of periodontology, 2015, Volume: 86, Issue:6 Topics: Alleles; Chronic Periodontitis; Cytosine; Gene Frequency; Genes, Dominant; Genes, Recessive; Genetic	2015
Positive association between IL-16 rs1131445 polymorphism and cancer risk: a meta-analysis. Minerva medica, 2016, Volume: 107, Issue:2 Topics: Alleles; Asian People; Biomarkers, Tumor; Cytosine; Databases, Factual; Evidence-Based Medicine; Gen	2016
High-throughput sequencing offers new insights into 5-hydroxymethylcytosine. Biomolecular concepts, 2016, Jun-01, Volume: 7, Issue:3 Topics: 5-Methylcytosine; Animals; Cytosine; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulatio	2016
Uracil in DNA--its biological significance. Mutation research, 2010, Volume: 705, Issue:3 Topics: Animals; B-Lymphocytes; Cytosine; Cytosine Deaminase; DNA; Drosophila melanogaster; Escherichia coli	2010
Association of the C-344T aldosterone synthase gene variant with essential hypertension: a meta-analysis. Journal of hypertension, 2007, Volume: 25, Issue:1 Topics: Aldosterone; Blood Pressure; Case-Control Studies; Cohort Studies; Cross-Sectional Studies; Cytochro	2007
Association between the T-381C polymorphism of the brain natriuretic peptide gene and risk of type 2 diabetes in human populations. Human molecular genetics, 2007, Jun-01, Volume: 16, Issue:11 Topics: Adult; Aged; Animals; Case-Control Studies; Chlorocebus aethiops; COS Cells; Cytosine; Diabetes Mell	2007
A meta-analysis of association between C677T polymorphism in the methylenetetrahydrofolate reductase gene and hypertension. European journal of human genetics : EJHG, 2007, Volume: 15, Issue:12 Topics: Asian People; Bias; Cytosine; Genetic Predisposition to Disease; Heterozygote; Humans; Hypertension;	2007

Article	Year
The RAD51 135G>C polymorphism is related to the effect of adjuvant therapy in early breast cancer. Journal of cancer research and clinical oncology, 2015, Volume: 141, Issue:5 Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chemotherapy, Adjuvan	2015
Host and microbiological factors related to dental caries development. Caries research, 2008, Volume: 42, Issue:5 Topics: C-Reactive Protein; Child; Cytosine; Dental Caries; Dental Caries Susceptibility; Dental Fistula; De	2008
MTHFR 677 CT/MTHFR 1298 CC genotypes are associated with increased risk of hypertension in Indians. Molecular and cellular biochemistry, 2007, Volume: 302, Issue:1-2 Topics: Asian People; Case-Control Studies; Cytosine; Female; Folic Acid; Gene Frequency; Genetic Predisposi	2007

Article	Year
Single-base editing of rs12603332 on chromosome 17q21 with a cytosine base editor regulates ORMDL3 and ATF6α expression. Allergy, 2022, Volume: 77, Issue:4 Topics: Asthma; Case-Control Studies; Chromosomes; Chromosomes, Human, Pair 17; Cytosine; Genetic Predisposi	2022
Changes in DNA methylation profiles of myalgic encephalomyelitis/chronic fatigue syndrome patients reflect systemic dysfunctions. Clinical epigenetics, 2020, 11-04, Volume: 12, Issue:1 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Case-Control Studies; Child; Cohort Studies; CpG Islands	2020
Androgen receptor cytosine, adenine, and guanine trinucleotide repeat polymorphism in Korean patients with endometriosis: A case-control study. European journal of obstetrics, gynecology, and reproductive biology, 2017, Volume: 218 Topics: Adenine; Alleles; Case-Control Studies; Chi-Square Distribution; Cytosine; Endometriosis; Female; Ge	2017
Cytosine methylation predicts renal function decline in American Indians. Kidney international, 2018, Volume: 93, Issue:6 Topics: Adult; Aged; Albuminuria; Apoptosis; Case-Control Studies; Cell Cycle; CpG Islands; Cytosine; Diabet	2018
Association between CA repeat polymorphism in IGF1 gene promoter and colorectal cancer risk in a native Chinese population. Neoplasma, 2019, Volume: 66, Issue:6 Topics: Adenine; Case-Control Studies; China; Colorectal Neoplasms; Cytosine; Female; Genetic Predisposition	2019
Polymorphic CT dinucleotide repeat in the GATA3 gene and risk of breast cancer in Iranian women. Medical oncology (Northwood, London, England), 2013, Volume: 30, Issue:2 Topics: Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Breast Neoplasms; Case-Control Studies; Cytosine;	2013
Succinate dehydrogenase deficiency is associated with decreased 5-hydroxymethylcytosine production in gastrointestinal stromal tumors: implications for mechanisms of tumorigenesis. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 2013, Volume: 26, Issue:11 Topics: 5-Methylcytosine; Biomarkers, Tumor; Cell Transformation, Neoplastic; Cytosine; DNA Mutational Analy	2013
Association of cell adhesion molecule gene polymorphisms with recurrent aphthous stomatitis. Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 2013, Volume: 42, Issue:10 Topics: Adenine; Adult; Alleles; Cell Adhesion Molecules; Cohort Studies; Cytosine; E-Selectin; Female; Gene	2013
Clinical outcomes of periodontal therapy are not influenced by the ATC/TTC haplotype in the IL8 gene. Journal of periodontal research, 2014, Volume: 49, Issue:4 Topics: Adenine; Adult; Chronic Periodontitis; Cytosine; Dental Plaque Index; Female; Follow-Up Studies; Gen	2014
Matrix metalloproteinase (MMP)-8 and tissue inhibitor of MMP-1 (TIMP-1) gene polymorphisms in generalized aggressive periodontitis: gingival crevicular fluid MMP-8 and TIMP-1 levels and outcome of periodontal therapy. Journal of periodontology, 2014, Volume: 85, Issue:8 Topics: Adenine; Adolescent; Adult; Aggressive Periodontitis; Alveolar Bone Loss; Biomarkers; Cytosine; Fema	2014
Th1 and Th2 polymorphisms in Sjögren's syndrome and rheumatoid arthritis. Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 2014, Volume: 43, Issue:6 Topics: Adenine; Adult; Aged; Antibodies, Antinuclear; Arthritis, Rheumatoid; Autoantigens; Case-Control Stu	2014
Association between cyclooxygenase-2 gene polymorphisms and head and neck squamous cell carcinoma risk. The Journal of craniofacial surgery, 2014, Volume: 25, Issue:2 Topics: 3' Untranslated Regions; Adenine; Adult; Aged; Alcohol Drinking; Carcinoma, Squamous Cell; Case-Cont	2014
Identification of genetic risk factors for maxillary lateral incisor agenesis. Journal of dental research, 2014, Volume: 93, Issue:5 Topics: Adenine; Anodontia; Axin Protein; Case-Control Studies; Cytosine; Ectodysplasins; Female; Fibroblast	2014
The association of CSF-1 gene polymorphism with chronic periodontitis in the Han Chinese population. Journal of periodontology, 2014, Volume: 85, Issue:8 Topics: Adult; Aged; Alveolar Bone Loss; Case-Control Studies; China; Chronic Periodontitis; Cytosine; Ethni	2014
Lack of association between a common polymorphism of the endothelial lipase gene and early-onset coronary artery disease in a Chinese Han population. Genetics and molecular research : GMR, 2014, Feb-20, Volume: 13, Issue:1 Topics: Asian People; Case-Control Studies; Coronary Artery Disease; Cytosine; Female; Gene Frequency; Genet	2014
Association study of c.910A>G and c.1686C>G polymorphisms in XRCC1 gene with risk of hepatocellular carcinoma in the Chinese population. Genetics and molecular research : GMR, 2014, Feb-28, Volume: 13, Issue:1 Topics: Adenine; Aged; Asian People; Carcinoma, Hepatocellular; Case-Control Studies; Cytosine; DNA-Binding	2014
IL-18 gene polymorphisms in aphthous stomatitis vs. Behçet's disease in a cohort of Egyptian patients. Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 2014, Volume: 43, Issue:10 Topics: Adenine; Adolescent; Adult; Behcet Syndrome; Case-Control Studies; Cohort Studies; Cytosine; Egypt;	2014
Association study of single nucleotide polymorphisms of MAFB with non-syndromic cleft lip with or without cleft palate in a population in Heilongjiang Province, northern China. The British journal of oral & maxillofacial surgery, 2014, Volume: 52, Issue:8 Topics: Adenine; Case-Control Studies; Child; Child, Preschool; China; Cleft Lip; Cleft Palate; Cytosine; Et	2014
Molecular characterization of a Chinese family carrying a novel C4329A mutation in mitochondrial tRNAIle and tRNAGln genes. BMC medical genetics, 2014, Jul-23, Volume: 15 Topics: Asian People; Case-Control Studies; Cytosine; DNA, Mitochondrial; Female; Genetic Predisposition to	2014
Genetic variants in AKT1 gene were associated with risk and survival of OSCC in Chinese Han Population. Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 2015, Volume: 44, Issue:1 Topics: Aged; Alleles; Carcinoma, Squamous Cell; China; Cohort Studies; Cytosine; Disease Progression; Ethni	2015
Interleukin 1β (+3954, -511 and -31) polymorphism in chronic periodontitis patients from North India. Acta odontologica Scandinavica, 2015, Volume: 73, Issue:5 Topics: Adult; Case-Control Studies; Chronic Periodontitis; Cytosine; Female; Gene Frequency; Genetic Predis	2015
Genetic association for caries susceptibility among cleft lip and/or palate individuals. The journal of contemporary dental practice, 2014, May-01, Volume: 15, Issue:3 Topics: Adolescent; Bone Morphogenetic Protein 4; Child; Child, Preschool; Cleft Lip; Cleft Palate; Cohort S	2014
Integrated analyses of DNA methylation and hydroxymethylation reveal tumor suppressive roles of ECM1, ATF5, and EOMES in human hepatocellular carcinoma. Genome biology, 2014, Dec-03, Volume: 15, Issue:12 Topics: 5-Methylcytosine; Activating Transcription Factors; Carcinoma, Hepatocellular; Cell Line, Tumor; Com	2014
RAGE gene polymorphism and environmental factor in the risk of oral cancer. Journal of dental research, 2015, Volume: 94, Issue:3 Topics: Adenine; Areca; Base Pairing; Base Sequence; Carcinogenesis; Case-Control Studies; Cytosine; Female;	2015
Association of single-nucleotide polymorphisms in the IRF6 gene with non-syndromic cleft lip with or without cleft palate in the Xinjiang Uyghur population. The British journal of oral & maxillofacial surgery, 2015, Volume: 53, Issue:3 Topics: 5' Flanking Region; 5' Untranslated Regions; Adenine; Case-Control Studies; Cleft Lip; Cleft Palate;	2015
The role of hOGG1 C1245G polymorphism in the susceptibility to lupus nephritis and modulation of the plasma 8-OHdG in patients with systemic lupus erythematosus. International journal of molecular sciences, 2015, Feb-09, Volume: 16, Issue:2 Topics: 8-Hydroxy-2'-Deoxyguanosine; Adult; Case-Control Studies; Cytosine; Deoxyguanosine; DNA Glycosylases	2015
Genome-wide 5-hydroxymethylcytosine modification pattern is a novel epigenetic feature of globozoospermia. Oncotarget, 2015, Mar-30, Volume: 6, Issue:9 Topics: 5-Methylcytosine; Case-Control Studies; Cell Shape; Cytosine; DNA; Epigenesis, Genetic; Gene Express	2015
Enamel formation genes associated with dental erosive wear. Caries research, 2015, Volume: 49, Issue:3 Topics: Adolescent; Amelogenesis; Amelogenin; Cytosine; Dental Enamel Proteins; Extracellular Matrix Protein	2015
A single nucleotide polymorphism in 3' untranslated region of epithelial growth factor receptor confers risk for pulmonary hypertension in chronic obstructive pulmonary disease. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2015, Volume: 36, Issue:1 Topics: 3' Untranslated Regions; Aged; Aged, 80 and over; Cells, Cultured; Cytosine; ErbB Receptors; Female;	2015
Lack of association of matrix metalloproteinase-9 promoter gene polymorphism in obstructive sleep apnea syndrome. Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery, 2015, Volume: 43, Issue:7 Topics: Adult; Body Mass Index; Cross-Sectional Studies; Cytosine; Female; Gene Frequency; Genetic Predispos	2015
Epigenetic Modifications in the Biology of Nonalcoholic Fatty Liver Disease: The Role of DNA Hydroxymethylation and TET Proteins. Medicine, 2015, Volume: 94, Issue:36 Topics: 5-Methylcytosine; Adult; Cytosine; DNA Methylation; DNA-Binding Proteins; Epigenesis, Genetic; Femal	2015
Relationship between cytosine-adenine repeat polymorphism of ADAMTS9 gene and clinical and radiologic severity of knee osteoarthritis. International journal of rheumatic diseases, 2018, Volume: 21, Issue:4 Topics: ADAMTS9 Protein; Adenine; Adult; Aged; Case-Control Studies; Chi-Square Distribution; Cytosine; Dise	2018
Mutation in a highly conserved glycine residue in strand 5B of plasminogen activator inhibitor 1 causes polymerisation. Thrombosis and haemostasis, 2017, 05-03, Volume: 117, Issue:5 Topics: Aged; Amino Acid Substitution; Animals; Arginine; Chlorocebus aethiops; Conserved Sequence; COS Cell	2017
Interferon-gamma and interleukin-12 gene polymorphisms and their relation to aggressive and chronic periodontitis and key periodontal pathogens. Journal of periodontology, 2008, Volume: 79, Issue:8 Topics: Adenine; Adult; Age Factors; Aggregatibacter actinomycetemcomitans; Alleles; Bacteria; Cytosine; Fem	2008
The association of interleukin-4 haplotypes with chronic periodontitis in a Czech population. Journal of periodontology, 2008, Volume: 79, Issue:10 Topics: 5' Flanking Region; Adult; Alleles; Base Pairing; Case-Control Studies; Chronic Periodontitis; Cytos	2008
E-selectin and L-selectin polymorphisms in patients with periodontitis. Journal of periodontal research, 2009, Volume: 44, Issue:1 Topics: Adenine; Adolescent; Adult; Aggressive Periodontitis; Alleles; Arginine; Chronic Periodontitis; Cyto	2009
DNA methylation and mRNA expression of SYN III, a candidate gene for schizophrenia. BMC medical genetics, 2008, Dec-22, Volume: 9 Topics: Animals; Brain; CpG Islands; Cytosine; DNA; DNA Methylation; Gene Expression; Genetic Predisposition	2008
Characterization of the action of antipsychotic subtypes on valproate-induced chromatin remodeling. Trends in pharmacological sciences, 2009, Volume: 30, Issue:2 Topics: Animals; Antipsychotic Agents; Cell Adhesion Molecules, Neuronal; Chromatin Assembly and Disassembly	2009
Analysis of the association of IL1B (C+3954T) and IL1RN (intron 2) polymorphisms with dental implant loss in a Brazilian population. Clinical oral implants research, 2009, Volume: 20, Issue:2 Topics: Adult; Aged; Aged, 80 and over; Brazil; Case-Control Studies; Cytosine; Dental Implants; Dental Rest	2009
PTPN22/LYP 1858C>T gene polymorphism and susceptibility to endometriosis in a Polish population. Journal of reproductive immunology, 2009, Volume: 79, Issue:2 Topics: Adult; Alleles; Cytosine; Endometriosis; Female; Genetic Predisposition to Disease; Genotype; Humans	2009
The PTPN22 C1858T (R620W) functional polymorphism in kidney transplantation. Transplantation proceedings, 2009, Volume: 41, Issue:2 Topics: Adult; Amino Acid Substitution; Chromosome Mapping; Chromosomes, Human, Pair 1; Cytosine; DNA; Femal	2009
Polymorphisms of XRCC1 gene and risk of gastric cardiac adenocarcinoma. Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus, 2009, Volume: 22, Issue:5 Topics: Adenine; Adenocarcinoma; Adult; Aged; Arginine; Cardia; Case-Control Studies; Codon; Cytosine; DNA R	2009
Formylpeptide receptor single nucleotide polymorphism 348T>C and its relationship to polymorphonuclear leukocyte chemotaxis in aggressive periodontitis. Journal of periodontology, 2009, Volume: 80, Issue:9 Topics: 5' Flanking Region; Adolescent; Adult; Aggressive Periodontitis; Black or African American; Chemotax	2009
Intrafamilial clinical phenotypic heterogeneity with MAPT gene splice site IVS10+16C>T mutation. Journal of the neurological sciences, 2009, Dec-15, Volume: 287, Issue:1-2 Topics: Atrophy; Base Sequence; Brain; Brain Chemistry; Cytosine; Disease Progression; DNA; DNA Mutational A	2009
Interleukin-1 gene cluster polymorphisms associated with periodontal disease in type 2 diabetes. Journal of periodontology, 2009, Volume: 80, Issue:10 Topics: Adult; Age Factors; Aged; Alleles; Case-Control Studies; Chronic Periodontitis; Cytosine; Dental Pla	2009
Genetic risk factors for periodontitis in a Japanese population. Journal of dental research, 2009, Volume: 88, Issue:12 Topics: Adult; Age Factors; Aggressive Periodontitis; Alveolar Bone Loss; Case-Control Studies; Chronic Peri	2009
Analysis of interactions between genetic variants of BMP4 and environmental factors with nonsyndromic cleft lip with or without cleft palate susceptibility. International journal of oral and maxillofacial surgery, 2010, Volume: 39, Issue:1 Topics: Adolescent; Adult; Alcohol Drinking; Biomarkers; Bone Morphogenetic Protein 4; Case-Control Studies;	2010
O6-methylguanine-DNA methyltransferase gene coding region polymorphisms and oral cancer risk. Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 2010, Volume: 39, Issue:8 Topics: Age Factors; Carcinoma, Squamous Cell; Case-Control Studies; Codon; Cytosine; Disease-Free Survival;	2010
Association of P53 codon 72 polymorphism and ameloblastoma. Oral diseases, 2010, Volume: 16, Issue:7 Topics: Alleles; Ameloblastoma; Arginine; Codon; Cytosine; Double-Blind Method; Female; Gene Frequency; Gene	2010
Polymorphisms in CYP2A13 and UGT1A7 genes and head and neck cancer susceptibility in North Indians. Oral diseases, 2010, Volume: 16, Issue:8 Topics: Alcohol Drinking; Aryl Hydrocarbon Hydroxylases; Carcinogens; Chromatography, High Pressure Liquid;	2010
Susceptibility locus for non-syndromic cleft lip with or without cleft palate on chromosome 10q25 confers risk in Estonian patients. European journal of oral sciences, 2010, Volume: 118, Issue:3 Topics: Adenine; Case-Control Studies; Chromosome Mapping; Chromosomes, Human, Pair 10; Cleft Lip; Cleft Pal	2010
Investigation of interleukin-13 gene polymorphisms in individuals with chronic and generalized aggressive periodontitis in a Taiwanese (Chinese) population. Journal of periodontal research, 2010, Volume: 45, Issue:5 Topics: Adult; Aggressive Periodontitis; Case-Control Studies; Chi-Square Distribution; China; Chronic Perio	2010
CRISPLD2 polymorphisms are associated with non-syndromic cleft lip with or without cleft palate in a northern Chinese population. European journal of oral sciences, 2010, Volume: 118, Issue:4 Topics: Adolescent; Adult; Case-Control Studies; Cell Adhesion Molecules; Child; Child, Preschool; China; Cl	2010
Polymorphisms in the Matrilin-1 gene and risk of mandibular prognathism in Koreans. Journal of dental research, 2010, Volume: 89, Issue:11 Topics: Adenine; Adult; Cartilage Oligomeric Matrix Protein; Case-Control Studies; Cytosine; Exons; Extracel	2010
Tumour necrosis factor-alpha gene polymorphisms and susceptibility to oral lichen planus. Oral diseases, 2011, Volume: 17, Issue:2 Topics: Adenine; Adult; Cytosine; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Guani	2011
Coronary heart disease and chronic periodontitis: is polymorphism of interleukin-6 gene the common risk factor in a Chinese population? Oral diseases, 2011, Volume: 17, Issue:3 Topics: Adenine; Adult; Aged; Alcohol Drinking; Case-Control Studies; China; Chromosome Mapping; Chronic Per	2011
Association of CDH1 promoter polymorphism and the risk of non-syndromic orofacial clefts in a Chinese Han population. Archives of oral biology, 2011, Volume: 56, Issue:1 Topics: Adenine; Antigens, CD; Cadherins; Case-Control Studies; Child, Preschool; China; Cleft Lip; Cleft Pa	2011
Association of IL1 gene polymorphisms with chronic periodontitis in Brazilians. Archives of oral biology, 2011, Volume: 56, Issue:1 Topics: Adult; Asian People; Black People; Brazil; Chronic Periodontitis; Cytosine; Ethnicity; Female; Gene	2011
Single nucleotide polymorphisms of pattern recognition receptors and chronic periodontitis. Journal of periodontal research, 2011, Volume: 46, Issue:2 Topics: Adenine; Chronic Periodontitis; Cytosine; Dental Plaque Index; Female; Gene Frequency; Genetic Predi	2011
Functionally significant nicotine acetylcholine receptor subunit α5 promoter haplotypes are associated with susceptibility to lung cancer in Chinese. Cancer, 2011, Oct-15, Volume: 117, Issue:20 Topics: Adult; Aged; Asian People; Case-Control Studies; China; Cytosine; Female; Gene Deletion; Gene Freque	2011
Functional variants of IL4 and IL6 genes and risk of tobacco-related oral carcinoma in high-risk Asian Indians. Oral diseases, 2011, Volume: 17, Issue:7 Topics: Adult; Aged; Aged, 80 and over; Asian People; Carcinoma, Squamous Cell; Case-Control Studies; Cytosi	2011
Impact of interleukin-8 gene polymorphisms and environmental factors on oral cancer susceptibility in Taiwan. Oral diseases, 2012, Volume: 18, Issue:3 Topics: 3' Untranslated Regions; Adenine; Areca; Carcinogens; Carcinoma, Squamous Cell; Case-Control Studies	2012
Survivin gene promoter polymorphism -31G/C as a risk factor for keratocystic odontogenic tumor development. European journal of oral sciences, 2012, Volume: 120, Issue:1 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Alleles; Case-Control Studies; Cytosine; Female; Genetic	2012
Influence of MMP-8 promoter polymorphism in early osseointegrated implant failure. Clinical oral investigations, 2013, Volume: 17, Issue:1 Topics: Alleles; Base Pairing; Cytosine; Dental Implants; Dental Restoration Failure; Gene Frequency; Geneti	2013
Genetic association study between Interleukin 10 gene and dental implant loss. Archives of oral biology, 2012, Volume: 57, Issue:9 Topics: Adenine; Alleles; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Cardiovascular	2012
Influence of cytotoxic T lymphocyte antigen-4 (CTLA-4) gene polymorphisms in periodontitis. Archives of oral biology, 2012, Volume: 57, Issue:9 Topics: Adenine; Adolescent; Adult; Aged; Aggressive Periodontitis; Alleles; Chronic Periodontitis; CTLA-4 A	2012
No association between transmembrane protein-tyrosine phosphatase receptor type C (PTPRC) exon A 77C>G transversion and liver transplant rejection. International journal of immunogenetics, 2012, Volume: 39, Issue:5 Topics: Adult; Aged; Cytosine; Exons; Female; Gene Frequency; Genetic Association Studies; Genetic Predispos	2012
Association of CD28 and CTLA-4 gene polymorphisms with aggressive periodontitis in Brazilians. Oral diseases, 2013, Volume: 19, Issue:6 Topics: Adenine; Adolescent; Adult; Aged; Aggressive Periodontitis; Brazil; CD28 Antigens; Chronic Periodont	2013
Enhanced CpG mutability and tumorigenesis in MBD4-deficient mice. Science (New York, N.Y.), 2002, Jul-19, Volume: 297, Issue:5580 Topics: 5-Methylcytosine; Alleles; Amino Acid Sequence; Animals; Base Pair Mismatch; Cytosine; Deamination;	2002
Germ-line variants in methyl-group metabolism genes and susceptibility to DNA methylation in normal tissues and human primary tumors. Cancer research, 2002, Aug-01, Volume: 62, Issue:15 Topics: 5-Methylcytosine; 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adenocarcinoma; Breast	2002
Evidence for a spontaneous C1840-T mutation in the RYR1 gene after DNA fingerprinting in a malignant hyperthermia susceptible family. Naunyn-Schmiedeberg's archives of pharmacology, 2002, Volume: 366, Issue:4 Topics: Adolescent; Adult; Aged; Child; Cytosine; DNA Fingerprinting; Female; Genetic Predisposition to Dise	2002
The -174 G/C polymorphism of the interleukin-6 gene promoter is associated with Alzheimer's disease in an Italian population [corrected]. Neuroreport, 2002, Sep-16, Volume: 13, Issue:13 Topics: Aged; Alzheimer Disease; Base Sequence; Cytosine; DNA Mutational Analysis; Encephalitis; Female; Gen	2002
In the elderly, interleukin-6 plasma levels and the -174G>C polymorphism are associated with the development of cardiovascular disease. Arteriosclerosis, thrombosis, and vascular biology, 2002, Dec-01, Volume: 22, Issue:12 Topics: Age Factors; Aged; Biomarkers; Cardiovascular Diseases; Case-Control Studies; Cytosine; Female; Foll	2002
The methylentetrahydrofolate reductase C677T point mutation is a risk factor for vascular access thrombosis in hemodialysis patients. American journal of kidney diseases : the official journal of the National Kidney Foundation, 2003, Volume: 41, Issue:3 Topics: Arteriovenous Shunt, Surgical; Cross-Sectional Studies; Cytosine; Female; Genetic Predisposition to	2003
Card15 and Crohn's disease: healthy homozygous carriers of the 3020insC frameshift mutation. The American journal of gastroenterology, 2003, Volume: 98, Issue:3 Topics: Adult; Aged; Carrier Proteins; Case-Control Studies; Crohn Disease; Cytosine; Electrophoresis, Agar	2003
Investigation of IL4 gene polymorphism in individuals with different levels of chronic periodontitis in a Brazilian population. Journal of clinical periodontology, 2003, Volume: 30, Issue:4 Topics: Adult; Alleles; Black People; Brazil; Chi-Square Distribution; Chronic Disease; Cytosine; Ethnicity;	2003
Polymorphism at position -174 of IL-6 gene is associated with susceptibility to chronic periodontitis in a Caucasian Brazilian population. Journal of clinical periodontology, 2003, Volume: 30, Issue:5 Topics: Adult; Alleles; Base Sequence; Brazil; Chi-Square Distribution; Chronic Disease; Cytosine; Female; G	2003
A polymorphism in the TCF7 gene, C883A, is associated with type 1 diabetes. Diabetes, 2003, Volume: 52, Issue:6 Topics: Adenine; California; Cytosine; Diabetes Mellitus, Type 1; DNA-Binding Proteins; Expressed Sequence T	2003
C766T low-density lipoprotein receptor-related protein 1 (LRP1) gene polymorphism and susceptibility to breast cancer. Breast cancer research : BCR, 2003, Volume: 5, Issue:3 Topics: Adult; Aged; Aged, 80 and over; Alleles; Biomarkers, Tumor; Breast Neoplasms; Cytosine; Female; Gene	2003
The impact of endothelial nitric oxide synthase polymorphisms on long-term renal allograft outcome. Transplant international : official journal of the European Society for Organ Transplantation, 2003, Volume: 16, Issue:6 Topics: Cadaver; Cohort Studies; Cytosine; Gene Frequency; Genetic Predisposition to Disease; Graft Rejectio	2003
Cathepsin D polymorphism in Italian elderly subjects with sporadic late-onset Alzheimer's disease. Dementia and geriatric cognitive disorders, 2003, Volume: 16, Issue:3 Topics: Age of Onset; Aged; Alleles; Alzheimer Disease; Apolipoproteins E; Case-Control Studies; Cathepsin D	2003
Progressive alterations in global and GC-rich DNA methylation during tumorigenesis. Toxicological sciences : an official journal of the Society of Toxicology, 2003, Volume: 75, Issue:2 Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogenicity Tests; Carcinogens; Cytosine; DNA Methyla	2003
Integrin beta3 Leu33Pro homozygosity and risk of cancer. Journal of the National Cancer Institute, 2003, Aug-06, Volume: 95, Issue:15 Topics: Adult; Aged; Aged, 80 and over; Alleles; Animals; Cytosine; Denmark; Disease Progression; Female; Ge	2003
Seasonal affective disorder and the G-protein beta-3-subunit C825T polymorphism. Biological psychiatry, 2004, Feb-01, Volume: 55, Issue:3 Topics: Alleles; Case-Control Studies; Cytosine; Female; Genetic Predisposition to Disease; Genotype; Hetero	2004
The C3435T MDR1 gene polymorphism is not associated with susceptibility for ulcerative colitis in Greek population. Gastroenterology, 2004, Volume: 126, Issue:1 Topics: Colitis, Ulcerative; Cytosine; Genes, MDR; Genetic Predisposition to Disease; Greece; Humans; Polymo	2004
Association between the interleukin-1beta C(-511)T polymorphism and blood pressure in a Chinese hypertensive population. Immunology letters, 2004, Feb-15, Volume: 91, Issue:2-3 Topics: Asian People; Blood Pressure; Cytosine; Female; Genetic Predisposition to Disease; Humans; Hypertens	2004
Association of a programmed death 1 gene polymorphism with the development of rheumatoid arthritis, but not systemic lupus erythematosus. Arthritis and rheumatism, 2004, Volume: 50, Issue:3 Topics: Alleles; Antigens, CD; Antigens, Surface; Apoptosis Regulatory Proteins; Arthritis, Rheumatoid; Cyto	2004
Body mass index and C-174G interleukin-6 promoter polymorphism interact in predicting type 2 diabetes. The Journal of clinical endocrinology and metabolism, 2004, Volume: 89, Issue:4 Topics: Body Mass Index; Case-Control Studies; Cohort Studies; Cytosine; Diabetes Mellitus, Type 2; Female;	2004
C18orf1 located on chromosome 18p11.2 may confer susceptibility to schizophrenia. Journal of medical and dental sciences, 2003, Volume: 50, Issue:3 Topics: Adult; Alleles; Case-Control Studies; Centromere; Chromosomes, Human, Pair 18; Cytosine; Exons; Fema	2003
Androgen receptor gene cytosine, adenine, and guanine trinucleotide repeats in patients with endometriosis. Journal of the Society for Gynecologic Investigation, 2004, Volume: 11, Issue:4 Topics: Adenine; Adult; Alleles; Cytosine; Endometriosis; Female; Gene Frequency; Genetic Predisposition to	2004
Interleukin 10 gene promoter polymorphisms are associated with chronic periodontitis. Journal of clinical periodontology, 2004, Volume: 31, Issue:6 Topics: Adenine; Adult; Chronic Disease; Cytosine; Female; Gene Frequency; Genetic Predisposition to Disease	2004
Lack of major involvement of human uroplakin genes in vesicoureteral reflux: implications for disease heterogeneity. Kidney international, 2004, Volume: 66, Issue:1 Topics: Alanine; Amino Acid Substitution; Animals; Base Sequence; Case-Control Studies; Chromosome Mapping;	2004
Transforming growth factor-beta 1 gene polymorphisms and cardiovascular disease in hemodialysis patients. Kidney international, 2004, Volume: 66, Issue:1 Topics: Aged; Cardiovascular Diseases; Codon; Cohort Studies; Cytosine; Death; Female; Genetic Predispositio	2004
The CHEK2 c.1100delC mutation plays an irrelevant role in breast cancer predisposition in Italy. Human mutation, 2004, Volume: 24, Issue:1 Topics: Breast Neoplasms; Checkpoint Kinase 2; Cytosine; Genetic Predisposition to Disease; Italy; Mutation;	2004
Common promoter C516T polymorphism in the ApoB gene is an independent predictor of carotid atherosclerotic disease in subjects presenting a broad range of plasma cholesterol levels. Arteriosclerosis, thrombosis, and vascular biology, 2004, Volume: 24, Issue:11 Topics: Apolipoproteins; Apolipoproteins B; Carotid Artery Diseases; Cholesterol; Cytosine; Female; Genetic	2004
Functional allelic heterogeneity and pleiotropy of a repeat polymorphism in tyrosine hydroxylase: prediction of catecholamines and response to stress in twins. Physiological genomics, 2004, Nov-17, Volume: 19, Issue:3 Topics: Adenine; Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Alleles; Autonomic Nervous System;	2004
PTPRC (CD45) C77G mutation does not contribute to multiple sclerosis susceptibility in Sardinian patients. Journal of neurology, 2004, Volume: 251, Issue:9 Topics: Alleles; Chi-Square Distribution; Cytosine; Female; Gene Frequency; Genetic Predisposition to Diseas	2004
Association of thymidylate synthase polymorphisms with gastric cancer susceptibility. International journal of cancer, 2004, Dec-20, Volume: 112, Issue:6 Topics: 3' Untranslated Regions; 5' Untranslated Regions; Adult; Aged; Aged, 80 and over; Case-Control Studi	2004
Hyperhomocysteinemia in central retinal vein occlusion in young adults. Seminars in ophthalmology, 2003, Volume: 18, Issue:3 Topics: Adult; Case-Control Studies; Cytosine; Female; Genetic Predisposition to Disease; Homozygote; Humans	2003
Polymorphisms of the interleukin-1beta gene affect the risk of myocardial infarction and ischemic stroke at young age and the response of mononuclear cells to stimulation in vitro. Arteriosclerosis, thrombosis, and vascular biology, 2005, Volume: 25, Issue:1 Topics: Adolescent; Adult; Child; Child, Preschool; Cytosine; Female; Genetic Predisposition to Disease; Hum	2005
Androgen receptor trinucleotide polymorphism in leiomyoma. Journal of assisted reproduction and genetics, 2004, Volume: 21, Issue:12 Topics: Adenine; Alleles; Cytosine; DNA; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype	2004
Association studies of the adenosine A2a receptor (1976T > C) genetic polymorphism in Parkinson's disease and schizophrenia. Journal of neural transmission (Vienna, Austria : 1996), 2005, Volume: 112, Issue:11 Topics: Age Distribution; Age of Onset; Aged; Asian People; Base Sequence; Brain; Brain Chemistry; Cytosine;	2005
Polymorphism of the adrenergic receptor alpha 2a -1291C>G genetic variation and clozapine-induced weight gain. Journal of neural transmission (Vienna, Austria : 1996), 2005, Volume: 112, Issue:11 Topics: Adult; Antipsychotic Agents; Base Sequence; Clozapine; Cytosine; Female; Genetic Predisposition to D	2005
The 825C/T polymorphism of G-protein beta3 subunit gene and risk of ischaemic stroke. Journal of human hypertension, 2005, Volume: 19, Issue:9 Topics: Aged; Asian People; Brain Ischemia; Case-Control Studies; Cytosine; Female; Gene Frequency; Genetic	2005
Association of apolipoprotein J gene 866C-->T polymorphism with preeclampsia and essential hypertension. Gynecologic and obstetric investigation, 2005, Volume: 60, Issue:3 Topics: Adult; Amino Acid Sequence; Case-Control Studies; China; Clusterin; Cytosine; DNA Mutational Analysi	2005
Transforming growth factor-beta1 SNPs: genetic and phenotypic correlations in progressive kidney insufficiency. Nephron. Experimental nephrology, 2005, Volume: 101, Issue:2 Topics: Adult; Aged; Aged, 80 and over; Arginine; Case-Control Studies; Cytosine; Disease Progression; Femal	2005
Association of mitochondrial deoxyribonucleic acid 16189 variant (T->C transition) with metabolic syndrome in Chinese adults. The Journal of clinical endocrinology and metabolism, 2005, Volume: 90, Issue:9 Topics: Aged; Asian People; Blood Glucose; Case-Control Studies; Cytosine; Diabetes Mellitus, Type 2; DNA, M	2005
Interleukin-2 receptor beta (IL-2R beta)-627C homozygote but not IL-12R beta 1 codon 378 or IL-18 105 polymorphism is associated with higher susceptibility to endometriosis. Fertility and sterility, 2005, Volume: 84, Issue:2* Topics: Alleles; Cytosine; Endometriosis; Female; Genetic Predisposition to Disease; Homozygote; Humans; Int	2005
Contribution of the collagen I alpha1 and vitamin D receptor genes to the risk of hip fracture in elderly women. The Journal of clinical endocrinology and metabolism, 2005, Volume: 90, Issue:12 Topics: Aged; Aged, 80 and over; Aging; Bone Density; Cohort Studies; Collagen Type I; Collagen Type I, alph	2005
CD14 and TLR4 gene polymorphisms in adult periodontitis. Journal of dental research, 2005, Volume: 84, Issue:11 Topics: Adult; Age Factors; Aged; Aggregatibacter actinomycetemcomitans; Aspartic Acid; Cytosine; Disease Su	2005
Congenital heart defects, maternal homocysteine, smoking, and the 677 C>T polymorphism in the methylenetetrahydrofolate reductase gene: evaluating gene-environment interactions. American journal of obstetrics and gynecology, 2006, Volume: 194, Issue:1 Topics: Adult; Case-Control Studies; Cytosine; Female; Genetic Predisposition to Disease; Genotype; Heart De	2006
No evidence for an association between the -871 T/C promoter polymorphism in the B-cell-activating factor gene and primary Sjögren's syndrome. Arthritis research & therapy, 2006, Volume: 8, Issue:1 Topics: Aged; B-Cell Activating Factor; Case-Control Studies; Cytosine; Female; Gene Frequency; Genetic Pred	2006
Genotype distribution of estrogen receptor-alpha, catechol-O-methyltransferase, and cytochrome P450 17 gene polymorphisms in Caucasian women with uterine leiomyomas. Fertility and sterility, 2006, Volume: 85, Issue:2 Topics: Adenine; Adult; Case-Control Studies; Catechol O-Methyltransferase; Cytosine; Estrogen Receptor alph	2006
[Meta-analysis of the association of the LRP C766T polymorphism with the risk of Alzheimer's disease]. Yi chuan = Hereditas, 2006, Volume: 28, Issue:4 Topics: Age of Onset; Alleles; Alzheimer Disease; Asian People; Association; Cytosine; Genetic Predispositio	2006
Methylenetetrahydrofolatereductase (MTHFR) 677C>T polymorphism and open angle glaucoma. Molecular vision, 2006, Apr-17, Volume: 12 Topics: Aged; Aged, 80 and over; Case-Control Studies; Cytosine; Exfoliation Syndrome; Female; Gene Frequenc	2006
Do allelic variants of the connexin37 1019 gene polymorphism differentially predict for coronary artery disease and myocardial infarction? Atherosclerosis, 2007, Volume: 191, Issue:2 Topics: Aged; Alleles; Connexins; Coronary Angiography; Coronary Artery Disease; Cytosine; Female; Gap Junct	2007
The -1131 T>C and S19W APOA5 gene polymorphisms are associated with high levels of triglycerides and apolipoprotein C-III, but not with coronary artery disease: an angiographic study. Atherosclerosis, 2007, Volume: 191, Issue:2 Topics: Adult; Aged; Apolipoprotein A-V; Apolipoprotein C-III; Apolipoproteins A; Coronary Angiography; Coro	2007
Functional variation in VEGF is not associated with type 2 diabetes in a United Kingdom Caucasian population. JOP : Journal of the pancreas, 2006, May-09, Volume: 7, Issue:3 Topics: Adenine; Adult; Case-Control Studies; Cytosine; Diabetes Mellitus, Type 2; Female; Gene Frequency; G	2006
Single nucleotide polymorphisms of tissue inhibitor of metalloproteinase genes in familial moyamoya disease. Neurosurgery, 2006, Volume: 58, Issue:6 Topics: Base Sequence; Case-Control Studies; Child; Child, Preschool; Cytosine; Female; Genetic Predispositi	2006
Maternal IVS1-401 T allele of the estrogen receptor alpha is an independent predictor of late fetal loss. Fertility and sterility, 2006, Volume: 86, Issue:2 Topics: Abortion, Spontaneous; Adenine; Alleles; Case-Control Studies; Cytosine; Estrogen Receptor alpha; Fa	2006
Single nucleotide polymorphism in exon 17 of the insulin receptor gene is not associated with polycystic ovary syndrome in a Korean population. Fertility and sterility, 2006, Volume: 86, Issue:2 Topics: Adult; Asian People; Case-Control Studies; Cytosine; Exons; Female; Gene Frequency; Genetic Predispo	2006
Prediction of genetic risk for metabolic syndrome. Atherosclerosis, 2007, Volume: 191, Issue:2 Topics: Aged; Apolipoprotein A-V; Apolipoproteins A; Asian People; Cholesterol, HDL; Cytosine; Female; Genet	2007
The short vitamin D receptor is associated with increased risk for generalized aggressive periodontitis. Journal of clinical periodontology, 2006, Volume: 33, Issue:8 Topics: Adenine; Adult; Alveolar Bone Loss; Codon; Cytosine; Exons; Female; Gene Frequency; Genetic Predispo	2006
Hereditary hyper-ACE-emia due to the Pro1199Leu mutation of somatic ACE as a potential pitfall in diagnosis: a first family outside Europe. Clinical chemistry and laboratory medicine, 2006, Volume: 44, Issue:9 Topics: Cytosine; Europe; Female; Genetic Predisposition to Disease; Granuloma; Humans; Leucine; Male; Pepti	2006
CARD15 gene variants in aggressive periodontitis. Journal of clinical periodontology, 2006, Volume: 33, Issue:11 Topics: Adult; Arginine; Base Sequence; Case-Control Studies; Cytosine; Disease Susceptibility; DNA Transpos	2006
Relationship between IL-1A polymorphisms and gingival overgrowth in renal transplant recipients receiving Cyclosporin A. Journal of clinical periodontology, 2006, Volume: 33, Issue:11 Topics: Adult; Age Factors; Alleles; Cyclosporine; Cytosine; Female; Genetic Predisposition to Disease; Geno	2006
Connexin37 1019 gene polymorphism in myocardial infarction patients and centenarians. Atherosclerosis, 2007, Volume: 191, Issue:2 Topics: Aged, 80 and over; Alleles; Connexins; Cytosine; Gap Junction alpha-4 Protein; Gene Frequency; Genet	2007
A promoter polymorphism (-839 C > T) at the dopamine transporter gene is associated with attention deficit/hyperactivity disorder in Brazilian children. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 2007, Mar-05, Volume: 144B, Issue:2 Topics: Attention Deficit Disorder with Hyperactivity; Brazil; Child; Cytosine; Dopamine Plasma Membrane Tra	2007
Influence of the CD14 C260T promoter polymorphism on C-reactive protein levels in patients with coronary artery disease. The American journal of cardiology, 2006, Nov-01, Volume: 98, Issue:9 Topics: Adult; Aged; Alleles; Analysis of Variance; Biomarkers; C-Reactive Protein; Coronary Artery Disease;	2006
Functional polymorphisms in the matrix metalloproteinase-9 gene in relation to severity of chronic periodontitis. Journal of periodontology, 2006, Volume: 77, Issue:11 Topics: Adult; Alleles; Case-Control Studies; Chronic Disease; Cytosine; Czech Republic; Female; Gene Freque	2006
Investigation of the functional variant c.-169T > C of the Fc receptor-like 3 (FCRL3) gene in alopecia areata. International journal of immunogenetics, 2006, Volume: 33, Issue:6 Topics: Adolescent; Adult; Aged; Alopecia Areata; Case-Control Studies; Child; Cytosine; Female; Genetic Pre	2006
Methylenetetrahydrofolate reductase C677T-polymorphism and its association with alcohol withdrawal seizure. Alcoholism, clinical and experimental research, 2006, Volume: 30, Issue:12 Topics: Adult; Aged; Alcohol Drinking; Alcohol Withdrawal Seizures; Alcoholism; Case-Control Studies; Cytosi	2006
Factor XII gene (F12) -4C/C polymorphism in combination with low protein S activity is associated with deep vein thrombosis. Thrombosis and haemostasis, 2006, Volume: 96, Issue:6 Topics: Adolescent; Adult; Aged; Case-Control Studies; Child; Cytosine; Factor XII; Female; Gene Frequency;	2006
Association of genetic polymorphisms of ACADSB and COMT with human hypertension. Journal of hypertension, 2007, Volume: 25, Issue:1 Topics: Acyl-CoA Dehydrogenases; Adenine; Aged; Asian People; Blood Pressure; Cohort Studies; Cytosine; DNA-	2007
-391 C to G substitution in the regulator of G-protein signalling-2 promoter increases susceptibility to the metabolic syndrome in white European men: consistency between molecular and epidemiological studies. Journal of hypertension, 2007, Volume: 25, Issue:1 Topics: 3T3-L1 Cells; Adipocytes; Adipogenesis; Adult; Animals; CHO Cells; Cricetinae; Cricetulus; Cytosine;	2007
Polymorphism in the IL-1alpha (-889) locus associated with elevated risk of primary open angle glaucoma. Molecular vision, 2006, Nov-15, Volume: 12 Topics: Adult; Aged; Aged, 80 and over; Alleles; Asian People; Cytosine; Female; Genetic Predisposition to D	2006
Low-density lipoprotein receptor-related protein 1 polymorphism 663 C > T affects clotting factor VIII activity and increases the risk of venous thromboembolism. Journal of thrombosis and haemostasis : JTH, 2007, Volume: 5, Issue:3 Topics: Case-Control Studies; Cytosine; Factor VIII; Female; Gene Frequency; Genetic Predisposition to Disea	2007
Angiotensinogen promoter sequence variants in essential hypertension. American journal of hypertension, 2006, Volume: 19, Issue:12 Topics: Adenine; Angiotensinogen; Black or African American; Cohort Studies; Cytosine; Female; Gene Frequenc	2006
Single nucleotide polymorphisms of tissue inhibitor of metalloproteinase genes in familial moyamoya disease. Neurosurgery, 2007, Volume: 60, Issue:3 Topics: Base Sequence; Case-Control Studies; Child; Child, Preschool; Cytosine; Female; Genetic Predispositi	2007
The -11377 C>G promoter variant of the adiponectin gene, prevalence of coronary atherosclerosis, and incidence of vascular events in men. Thrombosis and haemostasis, 2007, Volume: 97, Issue:3 Topics: Adiponectin; Cardiovascular Diseases; Cohort Studies; Coronary Angiography; Coronary Artery Disease;	2007
Methylenetetrahydrofolate reductase C677T mutation and nonalcoholic fatty liver disease. Digestive diseases and sciences, 2007, Volume: 52, Issue:5 Topics: Adult; Case-Control Studies; Cytosine; Disease Progression; Fatty Liver; Female; Gene Frequency; Gen	2007
Glycoprotein VI polymorphisms and outcome after percutaneous coronary interventions. Thrombosis and haemostasis, 2007, Volume: 97, Issue:4 Topics: Angioplasty, Balloon, Coronary; CD36 Antigens; Cohort Studies; Coronary Artery Disease; Coronary Res	2007
Association of CD14, IL1B, IL6, IL10 and TNFA functional gene polymorphisms with symptomatic dental abscesses. International endodontic journal, 2007, Volume: 40, Issue:7 Topics: Abscess; Adenine; Adult; Age Factors; Case-Control Studies; Chromosome Mapping; Cross-Sectional Stud	2007
Evaluation of AC(n) and C(-106)T polymorphisms of the aldose reductase gene in Brazilian patients with DM1 and susceptibility to diabetic retinopathy. Molecular vision, 2007, May-23, Volume: 13 Topics: Adolescent; Adult; Aldehyde Reductase; Brazil; Child; Cytosine; Diabetes Mellitus, Type 1; Diabetic	2007
The endothelial nitric oxide synthase gene -786T/C polymorphism is a predictive factor for reattacks of coronary spasm. Pharmacogenetics and genomics, 2007, Volume: 17, Issue:8 Topics: Adult; Aged; Calcium Channel Blockers; Cause of Death; Coronary Artery Disease; Coronary Vasospasm;	2007
Association of methylenetetrahydrofolate reductase polymorphism and the risk of squamous cell carcinoma in renal transplant patients. Transplantation, 2007, Jul-15, Volume: 84, Issue:1 Topics: Alleles; Carcinoma, Squamous Cell; Cytosine; Female; Genetic Predisposition to Disease; Genotype; Gu	2007
Diabetic retinopathy and IGF-1 gene polymorphic cytosine-adenine repeats in a Southern Indian cohort. Ophthalmic research, 2007, Volume: 39, Issue:5 Topics: Adenine; Aged; Cohort Studies; Cytosine; Diabetic Retinopathy; Female; Genetic Predisposition to Dis	2007
Association of CA repeat polymorphism in estrogen receptor beta gene with postmenopausal osteoporosis in Chinese. Journal of genetics and genomics = Yi chuan xue bao, 2007, Volume: 34, Issue:10 Topics: Adenine; Alleles; Asian People; Base Sequence; Case-Control Studies; Cytosine; Dinucleotide Repeats;	2007
The vascular endothelial growth factor +405G>C polymorphism in endometriosis. Human reproduction (Oxford, England), 2008, Volume: 23, Issue:1 Topics: Adult; Alleles; Cytosine; Endometriosis; Female; Genetic Heterogeneity; Genetic Predisposition to Di	2008
A functional TNFRSF5 gene variant is associated with risk of lymphoma. Blood, 2008, Apr-15, Volume: 111, Issue:8 Topics: Adult; Aged; CD40 Antigens; CD40 Ligand; Confidence Intervals; Cytosine; Dendritic Cells; Genetic Pr	2008
-141C Ins/Del polymorphism of the dopamine D2 receptor gene is associated with schizophrenia in a Spanish population. Psychiatric genetics, 2008, Volume: 18, Issue:3 Topics: Age Distribution; Alleles; Case-Control Studies; Cytosine; Female; Gene Frequency; Genetic Predispos	2008
Polymorphisms in the DNA repair gene XPD: correlations with risk and age at onset of basal cell carcinoma. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 1999, Volume: 8, Issue:1 Topics: Adenine; Adult; Age Factors; Age of Onset; Alleles; Carcinoma, Basal Cell; Confidence Intervals; Cyt	1999
Oculoleptomeningeal amyloidosis associated with a new transthyretin variant Ser64. Archives of neurology, 1999, Volume: 56, Issue:9 Topics: Adolescent; Adult; Amyloidosis; Autoradiography; Central Nervous System Diseases; Cytosine; Genetic	1999
Children with stroke: polymorphism of the MTHFR gene, mild hyperhomocysteinemia, and vitamin status. Journal of child neurology, 2000, Volume: 15, Issue:5 Topics: Adolescent; Case-Control Studies; Child; Child, Preschool; Cytosine; Female; Folic Acid; Genetic Pre	2000
Methylenetetrahydrofolate reductase C677T genotype and venous thromboembolic disease. Respiration; international review of thoracic diseases, 2000, Volume: 67, Issue:6 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Case-Control Studies; Cytosine; Factor V; Female; France	2000
A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature, 2001, May-31, Volume: 411, Issue:6837 Topics: Adult; Alleles; Amino Acid Sequence; Base Sequence; Carrier Proteins; Case-Control Studies; Cell Lin	2001
A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature, 2001, May-31, Volume: 411, Issue:6837 Topics: Adult; Alleles; Amino Acid Sequence; Base Sequence; Carrier Proteins; Case-Control Studies; Cell Lin	2001
A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature, 2001, May-31, Volume: 411, Issue:6837 Topics: Adult; Alleles; Amino Acid Sequence; Base Sequence; Carrier Proteins; Case-Control Studies; Cell Lin	2001
A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature, 2001, May-31, Volume: 411, Issue:6837 Topics: Adult; Alleles; Amino Acid Sequence; Base Sequence; Carrier Proteins; Case-Control Studies; Cell Lin	2001
Psychiatric symptoms and CAG repeats in neurologically asymptomatic Huntington's disease gene carriers. Psychiatry research, 2001, Jul-24, Volume: 102, Issue:3 Topics: Adenine; Adult; Age of Onset; Cognition; Cytosine; Female; Genetic Predisposition to Disease; Guanin	2001
Altered global methylation of DNA: an epigenetic difference in susceptibility for lung cancer is associated with its progression. Human pathology, 2001, Volume: 32, Issue:8 Topics: 5-Methylcytosine; Antibodies, Monoclonal; Bronchi; Carcinoma, Squamous Cell; Cytosine; Disease Progr	2001
Analysis of the coding and the 5' flanking regions of the alpha-synuclein gene in patients with Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society, 2001, Volume: 16, Issue:6 Topics: Aged; Aged, 80 and over; alpha-Synuclein; Base Pair Mismatch; Case-Control Studies; Cytosine; Essent	2001
A -174G/C polymorphism of the interleukin-6 gene in patients with lacunar infarction. Neuroscience letters, 2002, May-10, Volume: 324, Issue:1 Topics: Aged; Brain; Brain Ischemia; Cerebral Infarction; Cohort Studies; Cytosine; Diabetes Complications;	2002
Effects of phenobarbital on DNA methylation in GC-rich regions of hepatic DNA from mice that exhibit different levels of susceptibility to liver tumorigenesis. Toxicological sciences : an official journal of the Society of Toxicology, 2002, Volume: 68, Issue:1 Topics: Animals; Carcinogens; Cocarcinogenesis; Cytosine; DNA; DNA Methylation; Genetic Predisposition to Di	2002

cytosine and Genetic Predisposition

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