cytosine has been researched along with Fragile X Syndrome in 17 studies
Fragile X Syndrome: A condition characterized genotypically by mutation of the distal end of the long arm of the X chromosome (at gene loci FRAXA or FRAXE) and phenotypically by cognitive impairment, hyperactivity, SEIZURES, language delay, and enlargement of the ears, head, and testes. INTELLECTUAL DISABILITY occurs in nearly all males and roughly 50% of females with the full mutation of FRAXA. (From Menkes, Textbook of Child Neurology, 5th ed, p226)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Fragile X-associated tremor/ataxia syndrome (FXTAS) is a late-onset neurodegenerative disorder in which patients carry premutation alleles of 55-200 CGG repeats in the FMR1 gene." | 5.40 | Genome-wide alteration of 5-hydroxymethylcytosine in a mouse model of fragile X-associated tremor/ataxia syndrome. ( Galloway, JN; Jin, P; Lin, L; Nelson, DL; Street, RC; Wu, H; Yao, B; Zalewski, ZA, 2014) |
| "Fragile X syndrome (FXS) and associated disorders are caused by expansion of the cytosine-guanine-guanine (CGG) trinucleotide repeat in the 5' untranslated region (UTR) of the Fragile X mental retardation-1 (FMR1) gene promoter." | 3.91 | A Robust Polymerase Chain Reaction-based Assay for Quantifying Cytosine-guanine-guanine Trinucleotide Repeats in Fragile X Mental Retardation-1 Gene. ( Cheung, WC; Choy, KW; Gui, B; Kwok, KY; Lim, R; Pietilä, S; Shi, M; Wang, H; Yang, Z; Zhu, X; Zhu, Y, 2019) |
| "Fragile X-associated tremor/ataxia syndrome (FXTAS) is a late-onset neurodegenerative disorder in which patients carry premutation alleles of 55-200 CGG repeats in the FMR1 gene." | 1.40 | Genome-wide alteration of 5-hydroxymethylcytosine in a mouse model of fragile X-associated tremor/ataxia syndrome. ( Galloway, JN; Jin, P; Lin, L; Nelson, DL; Street, RC; Wu, H; Yao, B; Zalewski, ZA, 2014) |
| "Fragile X syndrome is the most common form of inherited mental retardation in man." | 1.29 | High resolution methylation analysis of the FMR1 gene trinucleotide repeat region in fragile X syndrome. ( Hornstra, IK; Nelson, DL; Warren, ST; Yang, TP, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 8 (47.06) | 18.2507 |
| 2000's | 5 (29.41) | 29.6817 |
| 2010's | 3 (17.65) | 24.3611 |
| 2020's | 1 (5.88) | 2.80 |
| Authors | Studies |
|---|---|
| Yang, H | 1 |
| Wang, Y | 1 |
| Xiang, Y | 1 |
| Yadav, T | 1 |
| Ouyang, J | 1 |
| Phoon, L | 1 |
| Zhu, X | 2 |
| Shi, Y | 1 |
| Zou, L | 1 |
| Lan, L | 1 |
| Wang, H | 1 |
| Gui, B | 1 |
| Cheung, WC | 1 |
| Shi, M | 1 |
| Yang, Z | 1 |
| Kwok, KY | 1 |
| Lim, R | 1 |
| Pietilä, S | 1 |
| Zhu, Y | 1 |
| Choy, KW | 1 |
| Yao, B | 1 |
| Lin, L | 1 |
| Street, RC | 1 |
| Zalewski, ZA | 1 |
| Galloway, JN | 1 |
| Wu, H | 1 |
| Nelson, DL | 2 |
| Jin, P | 1 |
| Lombroso, PJ | 1 |
| Ogren, MP | 1 |
| Rochette, PJ | 1 |
| Lacoste, S | 1 |
| Therrien, JP | 1 |
| Bastien, N | 1 |
| Brash, DE | 1 |
| Drouin, R | 1 |
| Stöger, R | 2 |
| Genereux, DP | 1 |
| Hagerman, RJ | 1 |
| Hagerman, PJ | 2 |
| Tassone, F | 2 |
| Laird, CD | 2 |
| Chandler, SP | 1 |
| Kansagra, P | 1 |
| Hirst, MC | 1 |
| Arocena, DG | 1 |
| Iwahashi, CK | 1 |
| Won, N | 1 |
| Beilina, A | 1 |
| Ludwig, AL | 1 |
| Schwartz, PH | 1 |
| Snow, K | 1 |
| Doud, LK | 1 |
| Hagerman, R | 1 |
| Pergolizzi, RG | 1 |
| Erster, SH | 1 |
| Thibodeau, SN | 1 |
| Hornstra, IK | 1 |
| Warren, ST | 1 |
| Yang, TP | 1 |
| Kajimura, TM | 1 |
| Brown, WT | 1 |
| Jara, L | 1 |
| Aspillaga, M | 1 |
| Avendaño, I | 1 |
| Obreque, V | 1 |
| Blanco, R | 1 |
| Valenzuela, CY | 1 |
| Oostra, BA | 1 |
| Hoogeveen, AT | 1 |
| Meyer, GA | 1 |
| Blum, NJ | 1 |
| Hitchcock, W | 1 |
| Fortina, P | 1 |
| Mariappan, SV | 1 |
| Silks, LA | 1 |
| Bradbury, EM | 1 |
| Gupta, G | 1 |
| Romero, RM | 1 |
| Rojsitthisak, P | 1 |
| Haworth, IS | 1 |
| Camerino, G | 1 |
| Goodfellow, P | 1 |
2 reviews available for cytosine and Fragile X Syndrome
| Article | Year |
|---|---|
Animal model for fragile X syndrome.
Topics: Animals; Carrier Proteins; Codon; Cytosine; Disease Models, Animal; Fragile X Mental Retardation Pro | 1997 |
A fragile understanding.
Topics: 5-Methylcytosine; Brain; Cytosine; Female; Fetal Diseases; Fragile X Syndrome; Gene Expression Regul | 1991 |
15 other studies available for cytosine and Fragile X Syndrome
| Article | Year |
|---|---|
FMRP promotes transcription-coupled homologous recombination via facilitating TET1-mediated m5C RNA modification demethylation.
Topics: Cytosine; Demethylation; Fragile X Mental Retardation Protein; Fragile X Syndrome; Homologous Recomb | 2022 |
A Robust Polymerase Chain Reaction-based Assay for Quantifying Cytosine-guanine-guanine Trinucleotide Repeats in Fragile X Mental Retardation-1 Gene.
Topics: Blotting, Southern; Cytosine; Female; Fragile X Mental Retardation Protein; Fragile X Syndrome; Gene | 2019 |
Genome-wide alteration of 5-hydroxymethylcytosine in a mouse model of fragile X-associated tremor/ataxia syndrome.
Topics: 5-Methylcytosine; Animals; Ataxia; Base Sequence; Cerebellum; Consensus Sequence; Cytosine; Disease | 2014 |
Fragile X syndrome: keys to the molecular genetics of synaptic plasticity.
Topics: Amino Acid Sequence; Child; Cytosine; Exons; Female; Fragile X Mental Retardation Protein; Fragile X | 2008 |
Influence of cytosine methylation on ultraviolet-induced cyclobutane pyrimidine dimer formation in genomic DNA.
Topics: Base Sequence; Cells, Cultured; Chromosomes, Human, X; Cytosine; DNA Damage; DNA Methylation; DNA Pr | 2009 |
Testing the FMR1 promoter for mosaicism in DNA methylation among CpG sites, strands, and cells in FMR1-expressing males with fragile X syndrome.
Topics: Alleles; Base Sequence; Case-Control Studies; CpG Islands; Cytosine; DNA; DNA Methylation; Female; F | 2011 |
Fragile X (CGG)n repeats induce a transcriptional repression in cis upon a linked promoter: evidence for a chromatin mediated effect.
Topics: Animals; Chromatin; Cytosine; Disease Models, Animal; Enzyme Inhibitors; Fragile X Syndrome; Gene Ex | 2003 |
Induction of inclusion formation and disruption of lamin A/C structure by premutation CGG-repeat RNA in human cultured neural cells.
Topics: 5' Untranslated Regions; alpha-Crystallin B Chain; Apoptosis; Cell Nucleus; Cells, Cultured; Cytosin | 2005 |
Analysis of a CGG sequence at the FMR-1 locus in fragile X families and in the general population.
Topics: Blotting, Southern; Cytosine; DNA; Evaluation Studies as Topic; Female; Fragile X Mental Retardation | 1993 |
High resolution methylation analysis of the FMR1 gene trinucleotide repeat region in fragile X syndrome.
Topics: 5-Methylcytosine; Base Sequence; Cytosine; Dosage Compensation, Genetic; Female; Fragile X Syndrome; | 1993 |
Epigenetic variation illustrated by DNA methylation patterns of the fragile-X gene FMR1.
Topics: Alleles; Base Sequence; Chromosome Aberrations; Cloning, Molecular; CpG Islands; Cytosine; DNA; DNA | 1997 |
Distribution of (CGG)n and FMR-1 associated microsatellite alleles in a normal Chilean population.
Topics: Alleles; Chile; Cytosine; Fragile X Mental Retardation Protein; Fragile X Syndrome; Genetic Markers; | 1998 |
Absence of the fragile X CGG trinucleotide repeat expansion in girls diagnosed with a pervasive developmental disorder.
Topics: Autistic Disorder; Blotting, Southern; Child; Child, Preschool; Cohort Studies; Confidence Intervals | 1998 |
Fragile X DNA triplet repeats, (GCC)n, form hairpins with single hydrogen-bonded cytosine.cytosine mispairs at the CpG sites: isotope-edited nuclear magnetic resonance spectroscopy on (GCC)n with selective 15N4-labeled cytosine bases.
Topics: 5' Untranslated Regions; Base Pair Mismatch; Cytosine; DNA; Fragile X Mental Retardation Protein; Fr | 1998 |
DNA interstrand crosslink formation by mechlorethamine at a cytosine-cytosine mismatch pair: kinetics and sequence dependence.
Topics: Alkylating Agents; Base Composition; Base Pair Mismatch; Base Pairing; Base Sequence; Computer Simul | 2001 |