cytosine has been researched along with Ectromelia, Infectious in 11 studies
Ectromelia, Infectious: A viral infection of mice, causing edema and necrosis followed by limb loss.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We have used these biomarkers to establish the optimal dosing regimen for treatment and reveal that a single dose of 25 mg/kg of CMX001 can be efficacious at treating lethal mousepox when administered on days 4 or 5 post-infection." | 1.35 | Using biomarkers to stage disease progression in a lethal mousepox model treated with CMX001. ( Buller, RM; Lanier, R; Oberle, C; Painter, G; Parker, S; Robertson, A; Schriewer, J, 2008) |
| " An ether-lipid analogue of CDV, CMX001 (HDP-CDV), has potent antiviral activity against a range of DNA viruses including poxviruses, excellent oral bioavailability and minimal nephrotoxicity." | 1.35 | Efficacy of therapeutic intervention with an oral ether-lipid analogue of cidofovir (CMX001) in a lethal mousepox model. ( Almond, M; Buller, RM; Lampert, B; Oberle, C; Painter, G; Parker, S; Robertson, A; Touchette, E; Trost, LC, 2008) |
| " To improve the bioavailability of CDV, others synthesized alkoxyalkanol esters of CDV and observed >100-fold more activity than unmodified CDV against cowpox, vaccinia, and variola virus (VARV) replication." | 1.32 | Efficacy of oral active ether lipid analogs of cidofovir in a lethal mousepox model. ( Beadle, JR; Buller, RM; Hostetler, KY; Melman, L; Owens, G; Schriewer, J, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (54.55) | 29.6817 |
| 2010's | 5 (45.45) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Parker, S | 7 |
| Crump, R | 2 |
| Foster, S | 2 |
| Hartzler, H | 2 |
| Hembrador, E | 3 |
| Lanier, ER | 1 |
| Painter, G | 5 |
| Schriewer, J | 6 |
| Trost, LC | 2 |
| Buller, RM | 8 |
| Korom, M | 1 |
| Oberle, C | 3 |
| Robertson, A | 3 |
| Lanier, R | 3 |
| Siddiqui, AM | 1 |
| Chen, N | 1 |
| Bellone, CJ | 1 |
| Owens, G | 3 |
| Fredrickson, T | 1 |
| Chen, NG | 1 |
| Hruby, D | 1 |
| Jordan, R | 1 |
| Painter, W | 1 |
| Sagartz, JE | 1 |
| Mark Buller, R | 1 |
| Israely, T | 1 |
| Paran, N | 1 |
| Lustig, S | 1 |
| Erez, N | 1 |
| Politi, B | 1 |
| Shafferman, A | 1 |
| Melamed, S | 1 |
| Melman, L | 2 |
| Beadle, JR | 2 |
| Hostetler, KY | 2 |
| Robbins, SJ | 1 |
| Jackson, RJ | 1 |
| Fenner, F | 1 |
| Beaton, S | 1 |
| Medveczky, J | 1 |
| Ramshaw, IA | 1 |
| Ramsay, AJ | 1 |
| Trahan, J | 1 |
| Aldern, KA | 1 |
| Touchette, E | 1 |
| Almond, M | 1 |
| Lampert, B | 1 |
11 other studies available for cytosine and Ectromelia, Infectious
| Article | Year |
|---|---|
Co-administration of the broad-spectrum antiviral, brincidofovir (CMX001), with smallpox vaccine does not compromise vaccine protection in mice challenged with ectromelia virus.
Topics: Animals; Antiviral Agents; Cytosine; Ectromelia virus; Ectromelia, Infectious; Female; Humans; Immun | 2014 |
Buccal viral DNA as a trigger for brincidofovir therapy in the mousepox model of smallpox.
Topics: Animals; Antiviral Agents; Cytosine; Disease Models, Animal; DNA, Viral; Ectromelia virus; Ectromeli | 2017 |
Using biomarkers to stage disease progression in a lethal mousepox model treated with CMX001.
Topics: Alanine Transaminase; Animals; Antiviral Agents; Aspartate Aminotransferases; Biomarkers; Cell Line; | 2008 |
Mousepox in the C57BL/6 strain provides an improved model for evaluating anti-poxvirus therapies.
Topics: Animals; Antiviral Agents; Cell Line; Chlorocebus aethiops; Cytokines; Cytosine; Disease Models, Ani | 2009 |
Poxvirus interleukin-4 expression overcomes inherent resistance and vaccine-induced immunity: pathogenesis, prophylaxis, and antiviral therapy.
Topics: Animals; Antiviral Agents; Benzamides; Cytosine; Ectromelia virus; Ectromelia, Infectious; Female; G | 2011 |
Evaluation of disease and viral biomarkers as triggers for therapeutic intervention in respiratory mousepox - an animal model of smallpox.
Topics: Animals; Benzamides; Biomarkers, Pharmacological; Cell Line; Cytosine; Disease Models, Animal; Drug | 2012 |
A single cidofovir treatment rescues animals at progressive stages of lethal orthopoxvirus disease.
Topics: Animals; Antibodies, Viral; Antiviral Agents; Cidofovir; Cytosine; Disease Models, Animal; Ectromeli | 2012 |
Efficacy of oral active ether lipid analogs of cidofovir in a lethal mousepox model.
Topics: Administration, Oral; Animals; Antiviral Agents; Cidofovir; Cytosine; Disease Models, Animal; Dose-R | 2004 |
The efficacy of cidofovir treatment of mice infected with ectromelia (mousepox) virus encoding interleukin-4.
Topics: Animals; Antiviral Agents; Cidofovir; Cytosine; Ectromelia virus; Ectromelia, Infectious; Interleuki | 2005 |
Oral 1-O-octadecyl-2-O-benzyl-sn-glycero-3-cidofovir targets the lung and is effective against a lethal respiratory challenge with ectromelia virus in mice.
Topics: Administration, Oral; Animals; Cidofovir; Cytosine; Ectromelia virus; Ectromelia, Infectious; Female | 2007 |
Efficacy of therapeutic intervention with an oral ether-lipid analogue of cidofovir (CMX001) in a lethal mousepox model.
Topics: Administration, Oral; Animals; Antiviral Agents; Cidofovir; Cytosine; Ectromelia virus; Ectromelia, | 2008 |