cytosine has been researched along with Down Syndrome in 3 studies
Down Syndrome: A chromosome disorder associated either with an extra chromosome 21 or an effective trisomy for chromosome 21. Clinical manifestations include hypotonia, short stature, brachycephaly, upslanting palpebral fissures, epicanthus, Brushfield spots on the iris, protruding tongue, small ears, short, broad hands, fifth finger clinodactyly, Simian crease, and moderate to severe INTELLECTUAL DISABILITY. Cardiac and gastrointestinal malformations, a marked increase in the incidence of LEUKEMIA, and the early onset of ALZHEIMER DISEASE are also associated with this condition. Pathologic features include the development of NEUROFIBRILLARY TANGLES in neurons and the deposition of AMYLOID BETA-PROTEIN, similar to the pathology of ALZHEIMER DISEASE. (Menkes, Textbook of Child Neurology, 5th ed, p213)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Patients with trisomy 21 have an increased incidence of haematological disorders, including neonatal 'leukaemoid reaction' (transient myeloproliferative disorder [TMD]), and acute leukaemias." | 1.29 | Acute myeloid leukaemia in patients with trisomy 21 (Down syndrome) treated by bone marrow transplantation. ( Dalla Pozza, L; Goleta-Dy, A; Shaw, PJ; Stevens, MM, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (33.33) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Grömminger, S | 1 |
| Erkan, S | 1 |
| Schöck, U | 1 |
| Stangier, K | 1 |
| Bonnet, J | 1 |
| Schloo, R | 1 |
| Schubert, A | 1 |
| Prott, EC | 1 |
| Knoll, U | 1 |
| Stumm, M | 1 |
| von Kalle, C | 1 |
| Hofmann, W | 1 |
| Goleta-Dy, A | 1 |
| Dalla Pozza, L | 1 |
| Shaw, PJ | 1 |
| Stevens, MM | 1 |
| Benson, PF | 1 |
3 other studies available for cytosine and Down Syndrome
| Article | Year |
|---|---|
The influence of low molecular weight heparin medication on plasma DNA in pregnant women.
Topics: Anticoagulants; Blood Specimen Collection; Chromosome Disorders; Chromosomes, Human, Pair 13; Chromo | 2015 |
Acute myeloid leukaemia in patients with trisomy 21 (Down syndrome) treated by bone marrow transplantation.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Child, Preschool; Combi | 1994 |
RNA ssynthesis by Down's syndrome Leucocytes.
Topics: Adenine; Centrifugation, Density Gradient; Child; Cytosine; Down Syndrome; Female; Guanine; Humans; | 1971 |