cytosine has been researched along with Colorectal Cancer in 29 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "To investigate the behaviour of total plasma homocysteine (tHcy) and its most common genetic determinant defect, the methylenetetrahydrofolate reductase C677T (C677TMTHFR) polymorphism in patients with early stage colorectal carcinoma." | 7.73 | Total plasma homocysteine and methylenetetrahydrofolate reductase C677T polymorphism in patients with colorectal carcinoma. ( Battistelli, S; Bing, C; Roviello, F; Stefanoni, M; Vittoria, A, 2006) |
| " To identify functional phosphorylation sites involved in 5-fluorouracil (5-FU) resistance during its treatment of colorectal cancer cells, CRISPR-mediated cytosine base editor (CBE) and adenine base editor (ABE) are utilized for functional screens by mutating phosphorylated amino acids with two libraries specifically targeting 7779 and 10 149 phosphorylation sites." | 4.12 | Functional Phosphoproteomics in Cancer Chemoresistance Using CRISPR-Mediated Base Editors. ( Guo, J; Huang, S; Huang, X; Li, J; Li, M; Lin, J; Qiao, Y; Yu, W; Zhang, P; Zhao, Y, 2022) |
| "To investigate the behaviour of total plasma homocysteine (tHcy) and its most common genetic determinant defect, the methylenetetrahydrofolate reductase C677T (C677TMTHFR) polymorphism in patients with early stage colorectal carcinoma." | 3.73 | Total plasma homocysteine and methylenetetrahydrofolate reductase C677T polymorphism in patients with colorectal carcinoma. ( Battistelli, S; Bing, C; Roviello, F; Stefanoni, M; Vittoria, A, 2006) |
| "The authors investigated the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism in 101 metastatic colorectal cancer patients treated with 5-fluoropyrimidine-based therapy and in 196 healthy individuals by PCR-RFLP method." | 3.72 | [The clinical importance of methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism in the 5-fluoropyrimidine-based therapy of metastatic colorectal tumours]. ( Adleff, V; Budai, B; Czeglédi, F; Gyergyay, F; Hitre, E; Kralovánszky, J; Láng, I, 2004) |
| "Second, tumors occurring in homozygous carriers of the methionine synthase 2756G allele show a lower number of hypermethylated CpG islands of tumor suppressor genes (P = 0." | 1.31 | Germ-line variants in methyl-group metabolism genes and susceptibility to DNA methylation in normal tissues and human primary tumors. ( Avila, S; Capella, G; Esteller, M; Fraga, MF; Herman, JG; Paz, MF; Peinado, MA; Pollan, M; Sanchez-Cespedes, M, 2002) |
| "Methylation of hMLH1 promoter from a colorectal cancer cell line RKO and a gastric cancer cell line PACM82 was analyzed by DHPLC." | 1.31 | [Analysis of the methylation in CpG island by denaturing high-performance liquid chromatography]. ( Deng, D; Deng, G; Lü, Y, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (6.90) | 18.2507 |
| 2000's | 15 (51.72) | 29.6817 |
| 2010's | 9 (31.03) | 24.3611 |
| 2020's | 3 (10.34) | 2.80 |
| Authors | Studies |
|---|---|
| Li, J | 1 |
| Lin, J | 1 |
| Huang, S | 1 |
| Li, M | 1 |
| Yu, W | 1 |
| Zhao, Y | 1 |
| Guo, J | 1 |
| Zhang, P | 1 |
| Huang, X | 1 |
| Qiao, Y | 1 |
| Fang, H | 1 |
| Barbour, JA | 1 |
| Poulos, RC | 1 |
| Katainen, R | 1 |
| Aaltonen, LA | 1 |
| Wong, JWH | 1 |
| Jensen, SØ | 1 |
| Øgaard, N | 1 |
| Nielsen, HJ | 1 |
| Bramsen, JB | 1 |
| Andersen, CL | 1 |
| Al Abo, M | 1 |
| Sasanuma, H | 1 |
| Liu, X | 1 |
| Rajapakse, VN | 1 |
| Huang, SY | 1 |
| Kiselev, E | 1 |
| Takeda, S | 1 |
| Plunkett, W | 1 |
| Pommier, Y | 1 |
| Wang, Y | 1 |
| Zhang, X | 2 |
| Zou, G | 1 |
| Peng, S | 1 |
| Liu, C | 1 |
| Zhou, X | 1 |
| Kazlauskas, A | 1 |
| Darinskas, A | 1 |
| Meškys, R | 1 |
| Tamašauskas, A | 1 |
| Urbonavičius, J | 1 |
| Chao, XL | 1 |
| Wang, LL | 1 |
| Liu, R | 1 |
| Li, Y | 1 |
| Zhou, XJ | 1 |
| Fiedler, D | 1 |
| Hirsch, D | 1 |
| El Hajj, N | 1 |
| Yang, HH | 1 |
| Hu, Y | 1 |
| Sticht, C | 1 |
| Nanda, I | 1 |
| Belle, S | 1 |
| Rueschoff, J | 1 |
| Lee, MP | 1 |
| Ried, T | 1 |
| Haaf, T | 1 |
| Gaiser, T | 1 |
| Zhang, LT | 1 |
| Zhang, LJ | 1 |
| Zhang, JJ | 1 |
| Ye, XX | 1 |
| Xie, AM | 1 |
| Chen, LY | 1 |
| Kang, JX | 1 |
| Cai, C | 1 |
| Cho, E | 1 |
| Townsend, MK | 1 |
| Selhub, J | 1 |
| Paul, L | 1 |
| Rosner, B | 1 |
| Fuchs, CS | 1 |
| Willett, WC | 1 |
| Giovannucci, EL | 1 |
| Kang, KA | 1 |
| Zhang, R | 1 |
| Kim, GY | 1 |
| Bae, SC | 1 |
| Hyun, JW | 1 |
| Kudo, Y | 1 |
| Tateishi, K | 1 |
| Yamamoto, K | 1 |
| Yamamoto, S | 1 |
| Asaoka, Y | 1 |
| Ijichi, H | 1 |
| Nagae, G | 1 |
| Yoshida, H | 1 |
| Aburatani, H | 1 |
| Koike, K | 1 |
| Paz, MF | 1 |
| Avila, S | 1 |
| Fraga, MF | 1 |
| Pollan, M | 1 |
| Capella, G | 1 |
| Peinado, MA | 1 |
| Sanchez-Cespedes, M | 1 |
| Herman, JG | 1 |
| Esteller, M | 1 |
| Parker, AR | 1 |
| O'Meally, RN | 1 |
| Sahin, F | 1 |
| Su, GH | 1 |
| Racke, FK | 1 |
| Nelson, WG | 1 |
| DeWeese, TL | 1 |
| Eshleman, JR | 1 |
| Budai, B | 1 |
| Hitre, E | 1 |
| Adleff, V | 1 |
| Czeglédi, F | 1 |
| Gyergyay, F | 1 |
| Láng, I | 1 |
| Kralovánszky, J | 1 |
| Bicknell, DC | 1 |
| Bodmer, WF | 1 |
| Jiang, J | 1 |
| Gajalakshmi, V | 1 |
| Wang, J | 1 |
| Kuriki, K | 1 |
| Suzuki, S | 1 |
| Nakamura, S | 1 |
| Akasaka, S | 1 |
| Ishikawa, H | 1 |
| Tokudome, S | 1 |
| Lam, W | 1 |
| Park, SY | 1 |
| Leung, CH | 1 |
| Cheng, YC | 1 |
| Gilbert, J | 1 |
| Carducci, MA | 1 |
| Baker, SD | 1 |
| Dees, EC | 1 |
| Donehower, R | 1 |
| Koyama, T | 1 |
| Nakamura, T | 1 |
| Komoto, C | 1 |
| Sakaeda, T | 1 |
| Taniguchi, M | 1 |
| Okamura, N | 1 |
| Tamura, T | 1 |
| Aoyama, N | 1 |
| Kamigaki, T | 1 |
| Kuroda, Y | 1 |
| Kasuga, M | 1 |
| Kadoyama, K | 1 |
| Okumura, K | 1 |
| Battistelli, S | 1 |
| Vittoria, A | 1 |
| Stefanoni, M | 1 |
| Bing, C | 1 |
| Roviello, F | 1 |
| Choi, JH | 1 |
| Park, SH | 1 |
| Park, J | 1 |
| Park, BG | 1 |
| Cha, SJ | 1 |
| Kong, KH | 1 |
| Lee, KH | 1 |
| Park, AJ | 1 |
| Gusella, M | 1 |
| Padrini, R | 1 |
| Hiltunen, MO | 1 |
| Alhonen, L | 1 |
| Koistinaho, J | 1 |
| Myöhänen, S | 1 |
| Pääkkönen, M | 1 |
| Marin, S | 1 |
| Kosma, VM | 1 |
| Jänne, J | 1 |
| Toyota, M | 1 |
| Ho, C | 1 |
| Ahuja, N | 1 |
| Jair, KW | 1 |
| Li, Q | 1 |
| Ohe-Toyota, M | 1 |
| Baylin, SB | 1 |
| Issa, JP | 1 |
| Levine, AJ | 1 |
| Siegmund, KD | 1 |
| Ervin, CM | 1 |
| Diep, A | 1 |
| Lee, ER | 1 |
| Frankl, HD | 1 |
| Haile, RW | 1 |
| Jubb, AM | 1 |
| Bell, SM | 1 |
| Quirke, P | 1 |
| Deng, D | 1 |
| Deng, G | 1 |
| Lü, Y | 1 |
| Przybylowska, K | 1 |
| Smolarczyk, K | 1 |
| Blasiak, J | 1 |
| Kulig, A | 1 |
| Romanowicz-Makowska, H | 1 |
| Dziki, A | 1 |
| Ulanska, J | 1 |
| Pander, B | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Circulating Tumor DNA Guided vs Opportunistic Colonoscopy Screening for CRC Detection After Acute Colonic Diverticulitis - the Diverticulitis Study[NCT06023004] | 250 participants (Anticipated) | Observational | 2022-05-01 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for cytosine and Colorectal Cancer
| Article | Year |
|---|---|
G>C SNP of thymidylate synthase with respect to colorectal cancer.
Topics: Animals; Colorectal Neoplasms; Cytosine; Guanine; Humans; Polymorphism, Single Nucleotide; Thymidyla | 2007 |
Methylation and colorectal cancer.
Topics: Adenocarcinoma; Adenoma; Aged; Aging; Biomarkers, Tumor; Chromatin; Colorectal Neoplasms; CpG Island | 2001 |
1 trial available for cytosine and Colorectal Cancer
| Article | Year |
|---|---|
A Phase I study of the oral antimetabolite, CS-682, administered once daily 5 days per week in patients with refractory solid tumor malignancies.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Arabinonucleo | 2006 |
26 other studies available for cytosine and Colorectal Cancer
| Article | Year |
|---|---|
Functional Phosphoproteomics in Cancer Chemoresistance Using CRISPR-Mediated Base Editors.
Topics: Adenine; Amino Acids; Clustered Regularly Interspaced Short Palindromic Repeats; Colorectal Neoplasm | 2022 |
Mutational processes of distinct POLE exonuclease domain mutants drive an enrichment of a specific TP53 mutation in colorectal cancer.
Topics: Carcinogenesis; Colorectal Neoplasms; CpG Islands; Cytosine; Databases, Genetic; Datasets as Topic; | 2020 |
Enhanced Performance of DNA Methylation Markers by Simultaneous Measurement of Sense and Antisense DNA Strands after Cytosine Conversion.
Topics: Aged; Biomarkers, Tumor; Circulating Tumor DNA; Colorectal Neoplasms; Cytosine; DNA Methylation; DNA | 2020 |
TDP1 is Critical for the Repair of DNA Breaks Induced by Sapacitabine, a Nucleoside also Targeting ATM- and BRCA-Deficient Tumors.
Topics: Arabinonucleosides; BRCA2 Protein; Camptothecin; Colorectal Neoplasms; Cytarabine; Cytosine; DNA Bre | 2017 |
Detection and Application of 5-Formylcytosine and 5-Formyluracil in DNA.
Topics: Biomarkers, Tumor; Colorectal Neoplasms; Cytosine; DNA; Fluorescent Dyes; Humans; Mass Spectrometry; | 2019 |
Isocytosine deaminase Vcz as a novel tool for the prodrug cancer therapy.
Topics: Adenocarcinoma; Animals; Antimetabolites, Antineoplastic; Brain Neoplasms; Caco-2 Cells; Cell Line, | 2019 |
Association between CA repeat polymorphism in IGF1 gene promoter and colorectal cancer risk in a native Chinese population.
Topics: Adenine; Case-Control Studies; China; Colorectal Neoplasms; Cytosine; Female; Genetic Predisposition | 2019 |
Genome-wide DNA methylation analysis of colorectal adenomas with and without recurrence reveals an association between cytosine-phosphate-guanine methylation and histological subtypes.
Topics: Adenoma; Aged; Biomarkers, Tumor; Colorectal Neoplasms; CpG Islands; Cytosine; DNA Methylation; Earl | 2019 |
Quantification of the sixth DNA base 5-hydroxymethylcytosine in colorectal cancer tissue and C-26 cell line.
Topics: 5-Methylcytosine; Cell Line, Tumor; Cell Transformation, Neoplastic; Chromatography, Liquid; Colorec | 2013 |
Unmetabolized Folic Acid in Prediagnostic Plasma and the Risk of Colorectal Cancer.
Topics: Adult; Case-Control Studies; Colorectal Neoplasms; Cytosine; Dietary Supplements; Female; Folic Acid | 2015 |
Epigenetic changes induced by oxidative stress in colorectal cancer cells: methylation of tumor suppressor RUNX3.
Topics: Caco-2 Cells; Cell Line, Tumor; Colorectal Neoplasms; Core Binding Factor Alpha 3 Subunit; Cytosine; | 2012 |
Loss of 5-hydroxymethylcytosine is accompanied with malignant cellular transformation.
Topics: 5-Methylcytosine; Cell Line, Tumor; Cell Transformation, Neoplastic; Colorectal Neoplasms; Cytosine; | 2012 |
Germ-line variants in methyl-group metabolism genes and susceptibility to DNA methylation in normal tissues and human primary tumors.
Topics: 5-Methylcytosine; 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adenocarcinoma; Breast | 2002 |
Defective human MutY phosphorylation exists in colorectal cancer cell lines with wild-type MutY alleles.
Topics: Adenine; Adjuvants, Immunologic; Alleles; Amino Acid Sequence; Base Pair Mismatch; Carcinogens; Case | 2003 |
[The clinical importance of methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism in the 5-fluoropyrimidine-based therapy of metastatic colorectal tumours].
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Case-Control Studies | 2004 |
A mutated HLA-A*0101 allele in the colorectal cell line HCA-7.
Topics: 3' Untranslated Regions; Alleles; Base Pair Mismatch; Cell Line, Tumor; Cloning, Molecular; Colorect | 2005 |
Influence of the C161T but not Pro12Ala polymorphism in the peroxisome proliferator-activated receptor-gamma on colorectal cancer in an Indian population.
Topics: Adult; Aged; Alanine; Colonic Neoplasms; Colorectal Neoplasms; Cytosine; Gene Frequency; Haplotypes; | 2005 |
Apurinic/apyrimidinic endonuclease-1 protein level is associated with the cytotoxicity of L-configuration deoxycytidine analogs (troxacitabine and beta-L-2',3'-dideoxy-2',3'-didehydro-5-fluorocytidine) but not D-configuration deoxycytidine analogs (gemcit
Topics: Cell Line, Tumor; Cell Survival; Colorectal Neoplasms; Cytosine; Deoxycytidine; Dioxolanes; DNA-(Apu | 2006 |
MDR1 T-129C polymorphism can be predictive of differentiation, and thereby prognosis of colorectal adenocarcinomas in Japanese.
Topics: Adenocarcinoma; Cell Differentiation; Colorectal Neoplasms; Cytosine; DNA Primers; Gene Expression R | 2006 |
Total plasma homocysteine and methylenetetrahydrofolate reductase C677T polymorphism in patients with colorectal carcinoma.
Topics: Aged; Carcinoma; Cell Proliferation; Colorectal Neoplasms; Cytosine; Female; Genotype; Homocysteine; | 2006 |
Site-specific methylation of CpG nucleotides in the hTERT promoter region can control the expression of hTERT during malignant progression of colorectal carcinoma.
Topics: Binding Sites; Carcinoma; Colorectal Neoplasms; CpG Islands; Cytosine; DNA Methylation; DNA-Cytosine | 2007 |
Hypermethylation of the APC (adenomatous polyposis coli) gene promoter region in human colorectal carcinoma.
Topics: Adenoma; Colorectal Neoplasms; Cytosine; DNA Methylation; Genes, APC; Germ-Line Mutation; Humans; In | 1997 |
Identification of differentially methylated sequences in colorectal cancer by methylated CpG island amplification.
Topics: 5-Methylcytosine; Adenocarcinoma; Chondroitin Sulfate Proteoglycans; Cloning, Molecular; Colorectal | 1999 |
The methylenetetrahydrofolate reductase 677C-->T polymorphism and distal colorectal adenoma risk.
Topics: Adenoma; Aged; Case-Control Studies; Colorectal Neoplasms; Cytosine; Female; Genotype; Humans; Loss | 2000 |
[Analysis of the methylation in CpG island by denaturing high-performance liquid chromatography].
Topics: Adaptor Proteins, Signal Transducing; Carrier Proteins; Chromatography, High Pressure Liquid; Colore | 2001 |
A C/T polymorphism in the urokinase-type plasminogen activator gene in colorectal cancer.
Topics: Adult; Aged; Colorectal Neoplasms; Cytosine; DNA Primers; DNA, Neoplasm; Female; Gene Frequency; Gen | 2001 |