Page last updated: 2024-10-17

cytosine and Colorectal Cancer

cytosine has been researched along with Colorectal Cancer in 29 studies

Research Excerpts

ExcerptRelevanceReference
"To investigate the behaviour of total plasma homocysteine (tHcy) and its most common genetic determinant defect, the methylenetetrahydrofolate reductase C677T (C677TMTHFR) polymorphism in patients with early stage colorectal carcinoma."7.73Total plasma homocysteine and methylenetetrahydrofolate reductase C677T polymorphism in patients with colorectal carcinoma. ( Battistelli, S; Bing, C; Roviello, F; Stefanoni, M; Vittoria, A, 2006)
" To identify functional phosphorylation sites involved in 5-fluorouracil (5-FU) resistance during its treatment of colorectal cancer cells, CRISPR-mediated cytosine base editor (CBE) and adenine base editor (ABE) are utilized for functional screens by mutating phosphorylated amino acids with two libraries specifically targeting 7779 and 10 149 phosphorylation sites."4.12Functional Phosphoproteomics in Cancer Chemoresistance Using CRISPR-Mediated Base Editors. ( Guo, J; Huang, S; Huang, X; Li, J; Li, M; Lin, J; Qiao, Y; Yu, W; Zhang, P; Zhao, Y, 2022)
"To investigate the behaviour of total plasma homocysteine (tHcy) and its most common genetic determinant defect, the methylenetetrahydrofolate reductase C677T (C677TMTHFR) polymorphism in patients with early stage colorectal carcinoma."3.73Total plasma homocysteine and methylenetetrahydrofolate reductase C677T polymorphism in patients with colorectal carcinoma. ( Battistelli, S; Bing, C; Roviello, F; Stefanoni, M; Vittoria, A, 2006)
"The authors investigated the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism in 101 metastatic colorectal cancer patients treated with 5-fluoropyrimidine-based therapy and in 196 healthy individuals by PCR-RFLP method."3.72[The clinical importance of methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism in the 5-fluoropyrimidine-based therapy of metastatic colorectal tumours]. ( Adleff, V; Budai, B; Czeglédi, F; Gyergyay, F; Hitre, E; Kralovánszky, J; Láng, I, 2004)
"Second, tumors occurring in homozygous carriers of the methionine synthase 2756G allele show a lower number of hypermethylated CpG islands of tumor suppressor genes (P = 0."1.31Germ-line variants in methyl-group metabolism genes and susceptibility to DNA methylation in normal tissues and human primary tumors. ( Avila, S; Capella, G; Esteller, M; Fraga, MF; Herman, JG; Paz, MF; Peinado, MA; Pollan, M; Sanchez-Cespedes, M, 2002)
"Methylation of hMLH1 promoter from a colorectal cancer cell line RKO and a gastric cancer cell line PACM82 was analyzed by DHPLC."1.31[Analysis of the methylation in CpG island by denaturing high-performance liquid chromatography]. ( Deng, D; Deng, G; Lü, Y, 2001)

Research

Studies (29)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (6.90)18.2507
2000's15 (51.72)29.6817
2010's9 (31.03)24.3611
2020's3 (10.34)2.80

Authors

AuthorsStudies
Li, J1
Lin, J1
Huang, S1
Li, M1
Yu, W1
Zhao, Y1
Guo, J1
Zhang, P1
Huang, X1
Qiao, Y1
Fang, H1
Barbour, JA1
Poulos, RC1
Katainen, R1
Aaltonen, LA1
Wong, JWH1
Jensen, SØ1
Øgaard, N1
Nielsen, HJ1
Bramsen, JB1
Andersen, CL1
Al Abo, M1
Sasanuma, H1
Liu, X1
Rajapakse, VN1
Huang, SY1
Kiselev, E1
Takeda, S1
Plunkett, W1
Pommier, Y1
Wang, Y1
Zhang, X2
Zou, G1
Peng, S1
Liu, C1
Zhou, X1
Kazlauskas, A1
Darinskas, A1
Meškys, R1
Tamašauskas, A1
Urbonavičius, J1
Chao, XL1
Wang, LL1
Liu, R1
Li, Y1
Zhou, XJ1
Fiedler, D1
Hirsch, D1
El Hajj, N1
Yang, HH1
Hu, Y1
Sticht, C1
Nanda, I1
Belle, S1
Rueschoff, J1
Lee, MP1
Ried, T1
Haaf, T1
Gaiser, T1
Zhang, LT1
Zhang, LJ1
Zhang, JJ1
Ye, XX1
Xie, AM1
Chen, LY1
Kang, JX1
Cai, C1
Cho, E1
Townsend, MK1
Selhub, J1
Paul, L1
Rosner, B1
Fuchs, CS1
Willett, WC1
Giovannucci, EL1
Kang, KA1
Zhang, R1
Kim, GY1
Bae, SC1
Hyun, JW1
Kudo, Y1
Tateishi, K1
Yamamoto, K1
Yamamoto, S1
Asaoka, Y1
Ijichi, H1
Nagae, G1
Yoshida, H1
Aburatani, H1
Koike, K1
Paz, MF1
Avila, S1
Fraga, MF1
Pollan, M1
Capella, G1
Peinado, MA1
Sanchez-Cespedes, M1
Herman, JG1
Esteller, M1
Parker, AR1
O'Meally, RN1
Sahin, F1
Su, GH1
Racke, FK1
Nelson, WG1
DeWeese, TL1
Eshleman, JR1
Budai, B1
Hitre, E1
Adleff, V1
Czeglédi, F1
Gyergyay, F1
Láng, I1
Kralovánszky, J1
Bicknell, DC1
Bodmer, WF1
Jiang, J1
Gajalakshmi, V1
Wang, J1
Kuriki, K1
Suzuki, S1
Nakamura, S1
Akasaka, S1
Ishikawa, H1
Tokudome, S1
Lam, W1
Park, SY1
Leung, CH1
Cheng, YC1
Gilbert, J1
Carducci, MA1
Baker, SD1
Dees, EC1
Donehower, R1
Koyama, T1
Nakamura, T1
Komoto, C1
Sakaeda, T1
Taniguchi, M1
Okamura, N1
Tamura, T1
Aoyama, N1
Kamigaki, T1
Kuroda, Y1
Kasuga, M1
Kadoyama, K1
Okumura, K1
Battistelli, S1
Vittoria, A1
Stefanoni, M1
Bing, C1
Roviello, F1
Choi, JH1
Park, SH1
Park, J1
Park, BG1
Cha, SJ1
Kong, KH1
Lee, KH1
Park, AJ1
Gusella, M1
Padrini, R1
Hiltunen, MO1
Alhonen, L1
Koistinaho, J1
Myöhänen, S1
Pääkkönen, M1
Marin, S1
Kosma, VM1
Jänne, J1
Toyota, M1
Ho, C1
Ahuja, N1
Jair, KW1
Li, Q1
Ohe-Toyota, M1
Baylin, SB1
Issa, JP1
Levine, AJ1
Siegmund, KD1
Ervin, CM1
Diep, A1
Lee, ER1
Frankl, HD1
Haile, RW1
Jubb, AM1
Bell, SM1
Quirke, P1
Deng, D1
Deng, G1
Lü, Y1
Przybylowska, K1
Smolarczyk, K1
Blasiak, J1
Kulig, A1
Romanowicz-Makowska, H1
Dziki, A1
Ulanska, J1
Pander, B1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Circulating Tumor DNA Guided vs Opportunistic Colonoscopy Screening for CRC Detection After Acute Colonic Diverticulitis - the Diverticulitis Study[NCT06023004]250 participants (Anticipated)Observational2022-05-01Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

2 reviews available for cytosine and Colorectal Cancer

ArticleYear
G>C SNP of thymidylate synthase with respect to colorectal cancer.
    Pharmacogenomics, 2007, Volume: 8, Issue:8

    Topics: Animals; Colorectal Neoplasms; Cytosine; Guanine; Humans; Polymorphism, Single Nucleotide; Thymidyla

2007
Methylation and colorectal cancer.
    The Journal of pathology, 2001, Volume: 195, Issue:1

    Topics: Adenocarcinoma; Adenoma; Aged; Aging; Biomarkers, Tumor; Chromatin; Colorectal Neoplasms; CpG Island

2001

Trials

1 trial available for cytosine and Colorectal Cancer

ArticleYear
A Phase I study of the oral antimetabolite, CS-682, administered once daily 5 days per week in patients with refractory solid tumor malignancies.
    Investigational new drugs, 2006, Volume: 24, Issue:6

    Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Arabinonucleo

2006

Other Studies

26 other studies available for cytosine and Colorectal Cancer

ArticleYear
Functional Phosphoproteomics in Cancer Chemoresistance Using CRISPR-Mediated Base Editors.
    Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2022, Volume: 9, Issue:30

    Topics: Adenine; Amino Acids; Clustered Regularly Interspaced Short Palindromic Repeats; Colorectal Neoplasm

2022
Mutational processes of distinct POLE exonuclease domain mutants drive an enrichment of a specific TP53 mutation in colorectal cancer.
    PLoS genetics, 2020, Volume: 16, Issue:2

    Topics: Carcinogenesis; Colorectal Neoplasms; CpG Islands; Cytosine; Databases, Genetic; Datasets as Topic;

2020
Enhanced Performance of DNA Methylation Markers by Simultaneous Measurement of Sense and Antisense DNA Strands after Cytosine Conversion.
    Clinical chemistry, 2020, 07-01, Volume: 66, Issue:7

    Topics: Aged; Biomarkers, Tumor; Circulating Tumor DNA; Colorectal Neoplasms; Cytosine; DNA Methylation; DNA

2020
TDP1 is Critical for the Repair of DNA Breaks Induced by Sapacitabine, a Nucleoside also Targeting ATM- and BRCA-Deficient Tumors.
    Molecular cancer therapeutics, 2017, Volume: 16, Issue:11

    Topics: Arabinonucleosides; BRCA2 Protein; Camptothecin; Colorectal Neoplasms; Cytarabine; Cytosine; DNA Bre

2017
Detection and Application of 5-Formylcytosine and 5-Formyluracil in DNA.
    Accounts of chemical research, 2019, 04-16, Volume: 52, Issue:4

    Topics: Biomarkers, Tumor; Colorectal Neoplasms; Cytosine; DNA; Fluorescent Dyes; Humans; Mass Spectrometry;

2019
Isocytosine deaminase Vcz as a novel tool for the prodrug cancer therapy.
    BMC cancer, 2019, Mar-04, Volume: 19, Issue:1

    Topics: Adenocarcinoma; Animals; Antimetabolites, Antineoplastic; Brain Neoplasms; Caco-2 Cells; Cell Line,

2019
Association between CA repeat polymorphism in IGF1 gene promoter and colorectal cancer risk in a native Chinese population.
    Neoplasma, 2019, Volume: 66, Issue:6

    Topics: Adenine; Case-Control Studies; China; Colorectal Neoplasms; Cytosine; Female; Genetic Predisposition

2019
Genome-wide DNA methylation analysis of colorectal adenomas with and without recurrence reveals an association between cytosine-phosphate-guanine methylation and histological subtypes.
    Genes, chromosomes & cancer, 2019, Volume: 58, Issue:11

    Topics: Adenoma; Aged; Biomarkers, Tumor; Colorectal Neoplasms; CpG Islands; Cytosine; DNA Methylation; Earl

2019
Quantification of the sixth DNA base 5-hydroxymethylcytosine in colorectal cancer tissue and C-26 cell line.
    Bioanalysis, 2013, Volume: 5, Issue:7

    Topics: 5-Methylcytosine; Cell Line, Tumor; Cell Transformation, Neoplastic; Chromatography, Liquid; Colorec

2013
Unmetabolized Folic Acid in Prediagnostic Plasma and the Risk of Colorectal Cancer.
    Journal of the National Cancer Institute, 2015, Volume: 107, Issue:12

    Topics: Adult; Case-Control Studies; Colorectal Neoplasms; Cytosine; Dietary Supplements; Female; Folic Acid

2015
Epigenetic changes induced by oxidative stress in colorectal cancer cells: methylation of tumor suppressor RUNX3.
    Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2012, Volume: 33, Issue:2

    Topics: Caco-2 Cells; Cell Line, Tumor; Colorectal Neoplasms; Core Binding Factor Alpha 3 Subunit; Cytosine;

2012
Loss of 5-hydroxymethylcytosine is accompanied with malignant cellular transformation.
    Cancer science, 2012, Volume: 103, Issue:4

    Topics: 5-Methylcytosine; Cell Line, Tumor; Cell Transformation, Neoplastic; Colorectal Neoplasms; Cytosine;

2012
Germ-line variants in methyl-group metabolism genes and susceptibility to DNA methylation in normal tissues and human primary tumors.
    Cancer research, 2002, Aug-01, Volume: 62, Issue:15

    Topics: 5-Methylcytosine; 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adenocarcinoma; Breast

2002
Defective human MutY phosphorylation exists in colorectal cancer cell lines with wild-type MutY alleles.
    The Journal of biological chemistry, 2003, Nov-28, Volume: 278, Issue:48

    Topics: Adenine; Adjuvants, Immunologic; Alleles; Amino Acid Sequence; Base Pair Mismatch; Carcinogens; Case

2003
[The clinical importance of methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism in the 5-fluoropyrimidine-based therapy of metastatic colorectal tumours].
    Magyar onkologia, 2004, Volume: 48, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Case-Control Studies

2004
A mutated HLA-A*0101 allele in the colorectal cell line HCA-7.
    Tissue antigens, 2005, Volume: 66, Issue:3

    Topics: 3' Untranslated Regions; Alleles; Base Pair Mismatch; Cell Line, Tumor; Cloning, Molecular; Colorect

2005
Influence of the C161T but not Pro12Ala polymorphism in the peroxisome proliferator-activated receptor-gamma on colorectal cancer in an Indian population.
    Cancer science, 2005, Volume: 96, Issue:8

    Topics: Adult; Aged; Alanine; Colonic Neoplasms; Colorectal Neoplasms; Cytosine; Gene Frequency; Haplotypes;

2005
Apurinic/apyrimidinic endonuclease-1 protein level is associated with the cytotoxicity of L-configuration deoxycytidine analogs (troxacitabine and beta-L-2',3'-dideoxy-2',3'-didehydro-5-fluorocytidine) but not D-configuration deoxycytidine analogs (gemcit
    Molecular pharmacology, 2006, Volume: 69, Issue:5

    Topics: Cell Line, Tumor; Cell Survival; Colorectal Neoplasms; Cytosine; Deoxycytidine; Dioxolanes; DNA-(Apu

2006
MDR1 T-129C polymorphism can be predictive of differentiation, and thereby prognosis of colorectal adenocarcinomas in Japanese.
    Biological & pharmaceutical bulletin, 2006, Volume: 29, Issue:7

    Topics: Adenocarcinoma; Cell Differentiation; Colorectal Neoplasms; Cytosine; DNA Primers; Gene Expression R

2006
Total plasma homocysteine and methylenetetrahydrofolate reductase C677T polymorphism in patients with colorectal carcinoma.
    World journal of gastroenterology, 2006, Oct-14, Volume: 12, Issue:38

    Topics: Aged; Carcinoma; Cell Proliferation; Colorectal Neoplasms; Cytosine; Female; Genotype; Homocysteine;

2006
Site-specific methylation of CpG nucleotides in the hTERT promoter region can control the expression of hTERT during malignant progression of colorectal carcinoma.
    Biochemical and biophysical research communications, 2007, Sep-28, Volume: 361, Issue:3

    Topics: Binding Sites; Carcinoma; Colorectal Neoplasms; CpG Islands; Cytosine; DNA Methylation; DNA-Cytosine

2007
Hypermethylation of the APC (adenomatous polyposis coli) gene promoter region in human colorectal carcinoma.
    International journal of cancer, 1997, Mar-17, Volume: 70, Issue:6

    Topics: Adenoma; Colorectal Neoplasms; Cytosine; DNA Methylation; Genes, APC; Germ-Line Mutation; Humans; In

1997
Identification of differentially methylated sequences in colorectal cancer by methylated CpG island amplification.
    Cancer research, 1999, May-15, Volume: 59, Issue:10

    Topics: 5-Methylcytosine; Adenocarcinoma; Chondroitin Sulfate Proteoglycans; Cloning, Molecular; Colorectal

1999
The methylenetetrahydrofolate reductase 677C-->T polymorphism and distal colorectal adenoma risk.
    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2000, Volume: 9, Issue:7

    Topics: Adenoma; Aged; Case-Control Studies; Colorectal Neoplasms; Cytosine; Female; Genotype; Humans; Loss

2000
[Analysis of the methylation in CpG island by denaturing high-performance liquid chromatography].
    Zhonghua yi xue za zhi, 2001, Feb-10, Volume: 81, Issue:3

    Topics: Adaptor Proteins, Signal Transducing; Carrier Proteins; Chromatography, High Pressure Liquid; Colore

2001
A C/T polymorphism in the urokinase-type plasminogen activator gene in colorectal cancer.
    Journal of experimental & clinical cancer research : CR, 2001, Volume: 20, Issue:4

    Topics: Adult; Aged; Colorectal Neoplasms; Cytosine; DNA Primers; DNA, Neoplasm; Female; Gene Frequency; Gen

2001