cytosine has been researched along with Carcinoma, Hepatocellular in 34 studies
Carcinoma, Hepatocellular: A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.
| Excerpt | Relevance | Reference |
|---|---|---|
| "5-hmC and IDH2 expression in hepatocellular carcinoma (HCC) has yet to be determined." | 5.40 | High expression of 5-hydroxymethylcytosine and isocitrate dehydrogenase 2 is associated with favorable prognosis after curative resection of hepatocellular carcinoma. ( Dai, Z; Ding, ZB; Fan, J; Jin, L; Liu, WR; Peng, YF; Qiu, SJ; Shen, YH; Shi, YH; Tian, MX; Yang, LX; Zhou, J, 2014) |
| "However, the change of 5 hmC level in hepatocellular carcinoma (HCC) and association with clinical outcome were not well defined." | 5.39 | Decrease of 5-hydroxymethylcytosine is associated with progression of hepatocellular carcinoma through downregulation of TET1. ( Bian, XW; Bie, P; Chen, X; Cui, Y; Liu, C; Liu, L; Qian, C; Shan, J; Shen, J; Wu, L; Xia, F; Xu, Y; Yang, Z, 2013) |
| " The simultaneous detection of 5-methylcytosine and 5-hydroxymethylcytosine is likely to stimulate the discovery of aberrantly methylated genes with increased accuracy in human hepatocellular carcinoma." | 3.80 | Integrated analyses of DNA methylation and hydroxymethylation reveal tumor suppressive roles of ECM1, ATF5, and EOMES in human hepatocellular carcinoma. ( Gao, F; Huang, J; Lin, Z; Liu, W; Liu, X; Luo, H; Ou, Y; Wang, J; Wen, B; Xia, Y; Zhang, X; Zhou, B, 2014) |
| "TET1 knockdown in hepatoma cell lines decreased hmC deposition with cell growth suppression." | 1.62 | TET1 upregulation drives cancer cell growth through aberrant enhancer hydroxymethylation of HMGA2 in hepatocellular carcinoma. ( Aburatani, H; Fujita, T; Hayashi, A; Ichinose, M; Kamio, A; Kanki, Y; Kudo, Y; Midorikawa, Y; Nagae, G; Nakaki, R; Okabe, A; Osawa, T; Ota, S; Seki, M; Shirai, K; Tateishi, K; Tsutsumi, S; Yamamoto, S, 2021) |
| "5-hmC and IDH2 expression in hepatocellular carcinoma (HCC) has yet to be determined." | 1.40 | High expression of 5-hydroxymethylcytosine and isocitrate dehydrogenase 2 is associated with favorable prognosis after curative resection of hepatocellular carcinoma. ( Dai, Z; Ding, ZB; Fan, J; Jin, L; Liu, WR; Peng, YF; Qiu, SJ; Shen, YH; Shi, YH; Tian, MX; Yang, LX; Zhou, J, 2014) |
| "However, the change of 5 hmC level in hepatocellular carcinoma (HCC) and association with clinical outcome were not well defined." | 1.39 | Decrease of 5-hydroxymethylcytosine is associated with progression of hepatocellular carcinoma through downregulation of TET1. ( Bian, XW; Bie, P; Chen, X; Cui, Y; Liu, C; Liu, L; Qian, C; Shan, J; Shen, J; Wu, L; Xia, F; Xu, Y; Yang, Z, 2013) |
| "In the prostate cancer lines where MT-I was suppressed, glutathione-S-transferase-pi (GST-pi) was expressed." | 1.31 | Suppression of metallothionein-I/II expression and its probable molecular mechanisms. ( Ghoshal, K; Jacob, ST; Majumder, S, 2002) |
| "Worldwide, hepatocellular carcinoma (HCC) is more prevalent in men than in women, suggesting that sex hormones and/or X-chromosome-linked genes may be involved in hepatocarcinogenesis." | 1.31 | Androgen-receptor gene CAG repeats, plasma testosterone levels, and risk of hepatitis B-related hepatocellular carcinoma. ( Chang, HC; Chen, CJ; Chen, PJ; Cheng, SW; Hsiao, TJ; Lee, SD; Liaw, YF; Lin, MW; Lin, SM; Liu, CJ; Yang, SY; Yu, MW, 2000) |
| "Samples of hepatoma (hepatocellular carcinoma, HCC) and paired non-HCC liver tissues were obtained from 17 HCC patients." | 1.31 | Genome-wide hypomethylation in hepatocellular carcinogenesis. ( Chen, TC; Hsieh, SY; Lee, WC; Liaw, YF; Lin, CH; Sheen, IS; Shyu, WC, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (32.35) | 18.7374 |
| 1990's | 3 (8.82) | 18.2507 |
| 2000's | 7 (20.59) | 29.6817 |
| 2010's | 10 (29.41) | 24.3611 |
| 2020's | 3 (8.82) | 2.80 |
| Authors | Studies |
|---|---|
| Jia, Y | 1 |
| Liu, Z | 1 |
| Dai, M | 1 |
| Feng, J | 1 |
| Ye, L | 1 |
| Zhang, H | 2 |
| Dai, E | 1 |
| Galli, A | 1 |
| Munnia, A | 1 |
| Cellai, F | 1 |
| Tarocchi, M | 1 |
| Ceni, E | 1 |
| van Schooten, FJ | 1 |
| Godschalk, R | 1 |
| Giese, RW | 1 |
| Peluso, M | 1 |
| Shirai, K | 1 |
| Nagae, G | 1 |
| Seki, M | 1 |
| Kudo, Y | 1 |
| Kamio, A | 1 |
| Hayashi, A | 1 |
| Okabe, A | 1 |
| Ota, S | 1 |
| Tsutsumi, S | 1 |
| Fujita, T | 1 |
| Yamamoto, S | 1 |
| Nakaki, R | 1 |
| Kanki, Y | 1 |
| Osawa, T | 1 |
| Midorikawa, Y | 1 |
| Tateishi, K | 1 |
| Ichinose, M | 1 |
| Aburatani, H | 1 |
| Liu, J | 1 |
| Jiang, J | 1 |
| Mo, J | 1 |
| Liu, D | 1 |
| Cao, D | 1 |
| Wang, H | 2 |
| He, Y | 1 |
| Wang, P | 1 |
| Yan, Y | 1 |
| Yu, W | 1 |
| Liu, C | 1 |
| Liu, L | 1 |
| Chen, X | 1 |
| Shen, J | 1 |
| Shan, J | 1 |
| Xu, Y | 2 |
| Yang, Z | 1 |
| Wu, L | 1 |
| Xia, F | 1 |
| Bie, P | 1 |
| Cui, Y | 1 |
| Bian, XW | 1 |
| Qian, C | 1 |
| Shen, F | 2 |
| Huang, W | 2 |
| Qi, JH | 2 |
| Yuan, BF | 2 |
| Huang, JT | 1 |
| Zhou, X | 1 |
| Feng, YQ | 2 |
| Liu, YJ | 1 |
| Liu, SM | 2 |
| Tsuno, S | 1 |
| Wang, X | 1 |
| Shomori, K | 1 |
| Hasegawa, J | 1 |
| Miura, N | 1 |
| Xia, WF | 1 |
| Ma, XP | 1 |
| Li, XR | 1 |
| Dong, H | 1 |
| Yi, JL | 1 |
| Liu, WR | 1 |
| Tian, MX | 1 |
| Jin, L | 1 |
| Yang, LX | 1 |
| Ding, ZB | 1 |
| Shen, YH | 1 |
| Peng, YF | 1 |
| Zhou, J | 1 |
| Qiu, SJ | 1 |
| Dai, Z | 1 |
| Fan, J | 1 |
| Shi, YH | 1 |
| Gao, F | 1 |
| Xia, Y | 1 |
| Wang, J | 1 |
| Lin, Z | 1 |
| Ou, Y | 1 |
| Liu, X | 1 |
| Liu, W | 1 |
| Zhou, B | 2 |
| Luo, H | 1 |
| Wen, B | 1 |
| Zhang, X | 1 |
| Huang, J | 1 |
| Papatheodoridis, GV | 1 |
| Lampertico, P | 1 |
| Manolakopoulos, S | 1 |
| Lok, A | 1 |
| Chen, ML | 1 |
| Wang, Y | 1 |
| Pogribny, IP | 2 |
| James, SJ | 2 |
| Jacob, ST | 1 |
| Majumder, S | 1 |
| Ghoshal, K | 1 |
| WHITCUTT, JM | 1 |
| ROTH, JS | 1 |
| Jernigan, S | 1 |
| Pogribna, M | 1 |
| Lam, W | 1 |
| Leung, CH | 1 |
| Bussom, S | 1 |
| Cheng, YC | 2 |
| Grove, KL | 1 |
| Guo, X | 1 |
| Liu, SH | 1 |
| Gao, Z | 1 |
| Chu, CK | 1 |
| Heijtink, RA | 1 |
| Kruining, J | 1 |
| de Wilde, GA | 1 |
| Balzarini, J | 1 |
| de Clercq, E | 1 |
| Schalm, SW | 1 |
| Philippe, M | 1 |
| Larondelle, Y | 1 |
| Lemaigre, F | 1 |
| Mariamé, B | 1 |
| Delhez, H | 1 |
| Mason, P | 1 |
| Luzzatto, L | 1 |
| Rousseau, GG | 1 |
| Yu, MW | 1 |
| Cheng, SW | 1 |
| Lin, MW | 1 |
| Yang, SY | 1 |
| Liaw, YF | 2 |
| Chang, HC | 1 |
| Hsiao, TJ | 1 |
| Lin, SM | 1 |
| Lee, SD | 1 |
| Chen, PJ | 1 |
| Liu, CJ | 1 |
| Chen, CJ | 1 |
| Lin, CH | 1 |
| Hsieh, SY | 1 |
| Sheen, IS | 1 |
| Lee, WC | 1 |
| Chen, TC | 1 |
| Shyu, WC | 1 |
| Porntadavity, S | 1 |
| St Clair, DK | 1 |
| Zylka, JM | 1 |
| Plagemann, PG | 2 |
| Montalvo, A | 1 |
| Guerritore, D | 1 |
| Piccolella, E | 1 |
| Wohlhueter, RM | 1 |
| Marz, R | 1 |
| Graff, JC | 1 |
| Singer, J | 1 |
| Stellwagen, RH | 1 |
| Roberts-Ems, J | 1 |
| Riggs, AD | 1 |
| Lamar, C | 1 |
| Munger, WL | 1 |
| Pitot, HC | 1 |
| Sneider, TW | 2 |
| Reddy, R | 1 |
| Ro-Choi, TS | 1 |
| Henning, D | 1 |
| Shibata, H | 1 |
| Choi, YC | 1 |
| Busch, H | 1 |
| Nau, F | 1 |
| Nielsen, HR | 1 |
| Sjolin, KE | 1 |
| Nyholm, K | 1 |
| Baliga, BS | 1 |
| Wong, R | 1 |
| Borek, E | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase I Study of mRNA Vaccine for Patients With HBV-positive Advanced Hepatocellular Carcinoma[NCT05738447] | Phase 1 | 9 participants (Anticipated) | Interventional | 2023-02-15 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for cytosine and Carcinoma, Hepatocellular
| Article | Year |
|---|---|
Role of ten-eleven translocation proteins and 5-hydroxymethylcytosine in hepatocellular carcinoma.
Topics: 5-Methylcytosine; Animals; Biomarkers, Tumor; Carcinoma, Hepatocellular; Cytosine; Dioxygenases; DNA | 2019 |
Incidence of hepatocellular carcinoma in chronic hepatitis B patients receiving nucleos(t)ide therapy: a systematic review.
Topics: Adult; Antiviral Agents; Carcinoma, Hepatocellular; Cytosine; Female; Hepatitis B, Chronic; Humans; | 2010 |
32 other studies available for cytosine and Carcinoma, Hepatocellular
| Article | Year |
|---|---|
Decrease of 5-hydroxymethylcytosine in hepatitis B virus-related hepatocellular carcinoma: A cross-sectional study.
Topics: 5-Methylcytosine; Carcinoma, Hepatocellular; Cross-Sectional Studies; Cytosine; DNA Methylation; Hep | 2023 |
Ligation-Mediated Polymerase Chain Reaction Detection of 8-Oxo-7,8-Dihydro-2'-Deoxyguanosine and 5-Hydroxycytosine at the Codon 176 of the p53 Gene of Hepatitis C-Associated Hepatocellular Carcinoma Patients.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Carcinoma, Hepatocellular; Cell Line, Tumor; Codon; Cytosine; DNA Adduc | 2020 |
TET1 upregulation drives cancer cell growth through aberrant enhancer hydroxymethylation of HMGA2 in hepatocellular carcinoma.
Topics: Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Chromatin; Cytosine; Dioxygenases; | 2021 |
Global DNA 5-Hydroxymethylcytosine and 5-Formylcytosine Contents Are Decreased in the Early Stage of Hepatocellular Carcinoma.
Topics: 5-Methylcytosine; Carcinoma, Hepatocellular; Cytosine; DNA, Neoplasm; Female; Humans; Liver Neoplasm | 2019 |
Decrease of 5-hydroxymethylcytosine is associated with progression of hepatocellular carcinoma through downregulation of TET1.
Topics: 5-Methylcytosine; Animals; Blotting, Western; Carcinoma, Hepatocellular; Cell Line, Tumor; Cytosine; | 2013 |
Association of 5-methylcytosine and 5-hydroxymethylcytosine with mitochondrial DNA content and clinical and biochemical parameters in hepatocellular carcinoma.
Topics: 5-Methylcytosine; Adolescent; Adult; Aged; Aged, 80 and over; Carcinoma, Hepatocellular; Cytosine; D | 2013 |
Hsa-miR-520d induces hepatoma cells to form normal liver tissues via a stemness-mediated process.
Topics: 5-Methylcytosine; Animals; Carcinoma, Hepatocellular; Cell Dedifferentiation; Cell Differentiation; | 2014 |
Association study of c.910A>G and c.1686C>G polymorphisms in XRCC1 gene with risk of hepatocellular carcinoma in the Chinese population.
Topics: Adenine; Aged; Asian People; Carcinoma, Hepatocellular; Case-Control Studies; Cytosine; DNA-Binding | 2014 |
High expression of 5-hydroxymethylcytosine and isocitrate dehydrogenase 2 is associated with favorable prognosis after curative resection of hepatocellular carcinoma.
Topics: 5-Methylcytosine; Carcinoma, Hepatocellular; Cytosine; DNA Methylation; Female; Hepatectomy; Humans; | 2014 |
Integrated analyses of DNA methylation and hydroxymethylation reveal tumor suppressive roles of ECM1, ATF5, and EOMES in human hepatocellular carcinoma.
Topics: 5-Methylcytosine; Activating Transcription Factors; Carcinoma, Hepatocellular; Cell Line, Tumor; Com | 2014 |
Quantification of 5-methylcytosine and 5-hydroxymethylcytosine in genomic DNA from hepatocellular carcinoma tissues by capillary hydrophilic-interaction liquid chromatography/quadrupole TOF mass spectrometry.
Topics: 5-Methylcytosine; Biomarkers; Carcinoma, Hepatocellular; Chromatography, Liquid; Cytosine; DNA Methy | 2013 |
De novo methylation of the p16INK4A gene in early preneoplastic liver and tumors induced by folate/methyl deficiency in rats.
Topics: Adenoma; Animals; Base Sequence; Carcinoma, Hepatocellular; CpG Islands; Cytosine; Diet; DNA Methyla | 2002 |
Suppression of metallothionein-I/II expression and its probable molecular mechanisms.
Topics: Animals; Carcinoma, Hepatocellular; CCAAT-Enhancer-Binding Proteins; Cytosine; DNA-Binding Proteins; | 2002 |
RIBONUCLEIC ACID SYNTHESIS AND TURNOVER IN RAT LIVER AND IN A RAPIDLY GROWING TRANSPLANTABLE HEPATOMA.
Topics: Adenine; Carcinoma, Hepatocellular; Cytosine; Electrophoresis; Guanine; Histocytochemistry; Liver; L | 1964 |
Genomic hypomethylation is specific for preneoplastic liver in folate/methyl deficient rats and does not occur in non-target tissues.
Topics: Animals; Carcinoma, Hepatocellular; Cytosine; DNA Methylation; DNA Modification Methylases; DNA, Neo | 2004 |
The impact of hypoxic treatment on the expression of phosphoglycerate kinase and the cytotoxicity of troxacitabine and gemcitabine.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Carcinoma; Carcinoma, Hepatocellular; Cell H | 2007 |
Anticancer activity of beta-L-dioxolane-cytidine, a novel nucleoside analogue with the unnatural L configuration.
Topics: Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Division; Colonic Neoplasms; Cytarab | 1995 |
Inhibitory effects of acyclic nucleoside phosphonates on human hepatitis B virus and duck hepatitis B virus infections in tissue culture.
Topics: Adenine; Animals; Antiviral Agents; Carcinoma, Hepatocellular; Cytosine; Ducks; Hepatitis B virus; H | 1994 |
Promoter function of the human glucose-6-phosphate dehydrogenase gene depends on two GC boxes that are cell specifically controlled.
Topics: Base Sequence; Carcinoma, Hepatocellular; Cytosine; DNA-Binding Proteins; Gene Expression Regulation | 1994 |
Androgen-receptor gene CAG repeats, plasma testosterone levels, and risk of hepatitis B-related hepatocellular carcinoma.
Topics: Adenine; Adult; Aged; Carcinoma, Hepatocellular; Case-Control Studies; Cohort Studies; Cytosine; Gua | 2000 |
Genome-wide hypomethylation in hepatocellular carcinogenesis.
Topics: 5-Methylcytosine; Adult; Aged; Carcinoma, Hepatocellular; Cytosine; DNA (Cytosine-5-)-Methyltransfer | 2001 |
Transcriptional regulation of the human manganese superoxide dismutase gene: the role of specificity protein 1 (Sp1) and activating protein-2 (AP-2).
Topics: Base Sequence; Binding Sites; Carcinoma, Hepatocellular; Cell Line, Transformed; Cloning, Molecular; | 2002 |
Purine and pyrimidine transport by cultured Novikoff cells. Specificities and mechanism of transport and relationship to phosphoribosylation.
Topics: Adenine; Animals; Biological Transport, Active; Calorimetry; Carcinoma, Hepatocellular; Cell Line; C | 1975 |
Mitochondrial DNA of Yoshida ascites tumour cells. Physicochemical properties and biological function.
Topics: Animals; Carcinoma, Hepatocellular; Cell Nucleus; Cytosine; DNA, Mitochondrial; Guanine; Liver Neopl | 1976 |
The application of rapid kinetic techniques to the transport of thymidine and 3-O-Methylglucose into Mammalian cells in suspension culture.
Topics: Animals; Biological Transport, Active; Carcinoma, Hepatocellular; Cell Line; Cyanides; Cytosine; Dif | 1976 |
5-Methylcytosine content of rat hepatoma DNA substituted with bromodeoxyuridine.
Topics: Animals; Bromodeoxyuridine; Carcinoma, Hepatocellular; Cell Line; Cytosine; DNA, Neoplasm; Liver Neo | 1977 |
Studies on a 32S component of nuclear RNA.
Topics: Adenine; Animals; Carcinoma, Hepatocellular; Cell Nucleus; Centrifugation, Zonal; Chromatography, Ge | 1967 |
Methylation of mammalian deoxyribonucleic acid. II. The distribution of 5-methylcytosine in pyrimidine deoxyribonucleotide clusters in Novikoff hepatoma cell deoxyribonucleic acid.
Topics: Alkaline Phosphatase; Animals; Carbon Isotopes; Carcinoma, Hepatocellular; Cell Line; Cell Nucleus; | 1971 |
MOdified nucleosides of nuclear and nucleolar low molecular weight ribonucleic acid.
Topics: Adenine; Animals; Carcinoma, Hepatocellular; Cell Nucleolus; Cell Nucleus; Chromatography, Gel; Chro | 1972 |
Letter: On the source of "minor thymine" in DNA from a Novik off rat hepatoma cell line.
Topics: Animals; Carcinoma, Hepatocellular; Cell Line; Chromatography, Paper; Cytosine; Deamination; Deoxycy | 1973 |
Differences in in vivo methylation patterns of tyrosine and histidine transfer ribonucleic acids from rat liver and Novikoff hepatoma.
Topics: Adenine; Amino Acyl-tRNA Synthetases; Animals; Carcinoma, Hepatocellular; Chromatography, DEAE-Cellu | 1974 |
Beta-aminoisobutyric acid, a new probe for the metabolism of DNA and RNA in normal and tumorous tissue.
Topics: Aminoisobutyric Acids; Animals; Carbon Radioisotopes; Carcinoma, Hepatocellular; Cytosine; DNA; DNA, | 1974 |