cytosine has been researched along with Cancer of Pancreas in 18 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "The human pancreatic adenocarcinoma cell lines, AsPC-1, Capan-2, MIA PaCa-2 and Panc-1, were exposed to troxacitabine or gemcitabine alone or in combination, for 72 h, and the effects on cell growth were determined by electronic particle counting." | 3.74 | Synergistic activity of troxacitabine (Troxatyl) and gemcitabine in pancreatic cancer. ( Bouffard, DY; Cass, CE; Clarke, ML; Damaraju, VL; Gourdeau, H; Grey, M; Leblond, L; Mackey, JR; Wong, CK, 2007) |
| "Although gemcitabine is a mainstay of pancreatic cancer therapy, it is only moderately effective, and it would be desirable to measure drug uptake in patients." | 1.46 | In Vitro and In Vivo Comparison of Gemcitabine and the Gemcitabine Analog 1-(2'-deoxy-2'-fluoroarabinofuranosyl) Cytosine (FAC) in Human Orthotopic and Genetically Modified Mouse Pancreatic Cancer Models. ( Desai, P; Haimovitz-Friedman, A; Humm, JL; Kramer, RM; Lowery, MA; Pillarsetty, N; Romesser, PB; Russell, J, 2017) |
| "Analysis of pancreatic cancer samples revealed striking redistribution of 5-hmC sites in cancer cells and demonstrated enrichment of this modification at many oncogenic promoters such as GATA6." | 1.39 | Genome-wide hydroxymethylation tested using the HELP-GT assay shows redistribution in cancer. ( Bhagat, TD; Bhattacharyya, S; Campbell, N; Christopeit, M; Godley, L; Greally, JM; Maitra, A; Mazdo, J; Nischal, S; Parekh, S; Steidl, U; Suzuki, M; Vasanthakumar, A; Verma, A; Yu, Y, 2013) |
| " The main drawback in the use of most nucleoside anticancer agents originates from their hydrophilic nature, which property requires a high and frequent dosage for an intravenous administration." | 1.34 | Troxacitabine prodrugs for pancreatic cancer. ( Adema, AD; Alexander, LE; Chu, CK; Daft, J; Hoebe, EK; Narayanasamy, J; Peters, GJ; Radi, M, 2007) |
| "With these fluorescent tools, tumors and metastasis in host organs can be externally imaged down to the single-cell level." | 1.33 | Orthotopic metastatic (MetaMouse) models for discovery and development of novel chemotherapy. ( Hoffman, RM, 2005) |
| "MIA-PaCa-2-RFP pancreatic cancer cells were transduced with the Discosoma red fluorescent protein (RFP) and orthotopically implanted onto the pancreas of nude mice." | 1.32 | Selective antimetastatic activity of cytosine analog CS-682 in a red fluorescent protein orthotopic model of pancreatic cancer. ( Bouvet, M; Hoffman, RM; Katz, MH; Moossa, AR; Spivack, D; Takimoto, S, 2003) |
| "Gemcitabine was used as a positive control." | 1.31 | The new dioxolane, (-)-2'-deoxy-3'-oxacytidine (BCH-4556, troxacitabine), has activity against pancreatic human tumor xenografts. ( Jolivet, J; Locas, C; Marty, J; Von Hoff, DD; Weitman, S, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (5.56) | 18.7374 |
| 1990's | 1 (5.56) | 18.2507 |
| 2000's | 10 (55.56) | 29.6817 |
| 2010's | 5 (27.78) | 24.3611 |
| 2020's | 1 (5.56) | 2.80 |
| Authors | Studies |
|---|---|
| Bahado-Singh, RO | 1 |
| Turkoglu, O | 1 |
| Aydas, B | 1 |
| Vishweswaraiah, S | 1 |
| Çelik-Uzuner, S | 1 |
| Russell, J | 1 |
| Pillarsetty, N | 1 |
| Kramer, RM | 1 |
| Romesser, PB | 1 |
| Desai, P | 1 |
| Haimovitz-Friedman, A | 1 |
| Lowery, MA | 1 |
| Humm, JL | 1 |
| Bhattacharyya, S | 1 |
| Yu, Y | 1 |
| Suzuki, M | 1 |
| Campbell, N | 1 |
| Mazdo, J | 1 |
| Vasanthakumar, A | 1 |
| Bhagat, TD | 1 |
| Nischal, S | 1 |
| Christopeit, M | 1 |
| Parekh, S | 1 |
| Steidl, U | 1 |
| Godley, L | 1 |
| Maitra, A | 1 |
| Greally, JM | 1 |
| Verma, A | 1 |
| Nagaraju, GP | 1 |
| Zhu, S | 1 |
| Wen, J | 1 |
| Farris, AB | 1 |
| Adsay, VN | 1 |
| Diaz, R | 1 |
| Snyder, JP | 1 |
| Mamoru, S | 1 |
| El-Rayes, BF | 1 |
| Ueda, Y | 1 |
| Ooshio, I | 1 |
| Fusamae, Y | 1 |
| Kitae, K | 1 |
| Kawaguchi, M | 1 |
| Jingushi, K | 1 |
| Hase, H | 1 |
| Harada, K | 1 |
| Hirata, K | 1 |
| Tsujikawa, K | 1 |
| Katz, MH | 2 |
| Bouvet, M | 2 |
| Takimoto, S | 2 |
| Spivack, D | 2 |
| Moossa, AR | 2 |
| Hoffman, RM | 3 |
| Pang, RT | 1 |
| Lee, LT | 1 |
| Ng, SS | 1 |
| Yung, WH | 1 |
| Chow, BK | 1 |
| Lapointe, R | 1 |
| Létourneau, R | 1 |
| Steward, W | 1 |
| Hawkins, RE | 1 |
| Batist, G | 1 |
| Vincent, M | 1 |
| Whittom, R | 1 |
| Eatock, M | 1 |
| Jolivet, J | 2 |
| Moore, M | 1 |
| Lam, W | 1 |
| Leung, CH | 1 |
| Bussom, S | 1 |
| Cheng, YC | 1 |
| Damaraju, VL | 1 |
| Bouffard, DY | 1 |
| Wong, CK | 1 |
| Clarke, ML | 1 |
| Mackey, JR | 1 |
| Leblond, L | 1 |
| Cass, CE | 1 |
| Grey, M | 1 |
| Gourdeau, H | 1 |
| Adema, AD | 1 |
| Radi, M | 1 |
| Daft, J | 1 |
| Narayanasamy, J | 1 |
| Hoebe, EK | 1 |
| Alexander, LE | 1 |
| Chu, CK | 1 |
| Peters, GJ | 1 |
| Cate, RL | 1 |
| Chick, W | 1 |
| Gilbert, W | 1 |
| Weitman, S | 1 |
| Marty, J | 1 |
| Locas, C | 1 |
| Von Hoff, DD | 1 |
| Günzburg, WH | 1 |
| Salmons, B | 1 |
| Stridsberg, M | 1 |
| Wilander, E | 1 |
2 reviews available for cytosine and Cancer of Pancreas
| Article | Year |
|---|---|
Novel clinical strategies for the treatment of pancreatic carcinoma.
Topics: Adjuvants, Immunologic; Antibodies, Monoclonal; Antineoplastic Agents; Bile; Biotransformation; Canc | 2001 |
Islet amyloid polypeptide (IAPP). A short review.
Topics: Animals; Cytosine; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Humans; Pancreatic Neoplasm | 1991 |
1 trial available for cytosine and Cancer of Pancreas
| Article | Year |
|---|---|
Phase II study of troxacitabine in chemotherapy-naive patients with advanced cancer of the pancreas: gastrointestinal tumors.
Topics: Adult; Aged; Antineoplastic Agents; Body Weight; Cytosine; Dioxolanes; Disease Progression; Female; | 2005 |
15 other studies available for cytosine and Cancer of Pancreas
| Article | Year |
|---|---|
Precision oncology: Artificial intelligence, circulating cell-free DNA, and the minimally invasive detection of pancreatic cancer-A pilot study.
Topics: Artificial Intelligence; Biomarkers, Tumor; Cell-Free Nucleic Acids; Cytosine; DNA Methylation; Huma | 2023 |
Precision oncology: Artificial intelligence, circulating cell-free DNA, and the minimally invasive detection of pancreatic cancer-A pilot study.
Topics: Artificial Intelligence; Biomarkers, Tumor; Cell-Free Nucleic Acids; Cytosine; DNA Methylation; Huma | 2023 |
Precision oncology: Artificial intelligence, circulating cell-free DNA, and the minimally invasive detection of pancreatic cancer-A pilot study.
Topics: Artificial Intelligence; Biomarkers, Tumor; Cell-Free Nucleic Acids; Cytosine; DNA Methylation; Huma | 2023 |
Precision oncology: Artificial intelligence, circulating cell-free DNA, and the minimally invasive detection of pancreatic cancer-A pilot study.
Topics: Artificial Intelligence; Biomarkers, Tumor; Cell-Free Nucleic Acids; Cytosine; DNA Methylation; Huma | 2023 |
Enhanced immunological detection of epigenetic modifications of DNA in healthy and cancerous cells by fluorescence microscopy.
Topics: Animals; Cell Line, Tumor; Cytosine; DNA; DNA Methylation; Female; Fluorescent Antibody Technique; H | 2019 |
In Vitro and In Vivo Comparison of Gemcitabine and the Gemcitabine Analog 1-(2'-deoxy-2'-fluoroarabinofuranosyl) Cytosine (FAC) in Human Orthotopic and Genetically Modified Mouse Pancreatic Cancer Models.
Topics: Animals; Cell Line, Tumor; Cytosine; Deoxycytidine; Female; Gemcitabine; Humans; Mice, Nude; Mice, T | 2017 |
Genome-wide hydroxymethylation tested using the HELP-GT assay shows redistribution in cancer.
Topics: 5-Methylcytosine; Animals; Cell Line, Tumor; Cell Transformation, Neoplastic; Cytosine; DNA, Neoplas | 2013 |
Novel synthetic curcumin analogues EF31 and UBS109 are potent DNA hypomethylating agents in pancreatic cancer.
Topics: Animals; Blotting, Western; Cadherins; Cell Line, Tumor; Cell Proliferation; Cell Survival; Curcumin | 2013 |
AlkB homolog 3-mediated tRNA demethylation promotes protein synthesis in cancer cells.
Topics: Adenine; AlkB Homolog 3, Alpha-Ketoglutarate-Dependent Dioxygenase; AlkB Homolog 5, RNA Demethylase; | 2017 |
Selective antimetastatic activity of cytosine analog CS-682 in a red fluorescent protein orthotopic model of pancreatic cancer.
Topics: Animals; Arabinonucleosides; Cell Division; Cytosine; Humans; Luminescent Proteins; Male; Mice; Mice | 2003 |
CpG methylation and transcription factors Sp1 and Sp3 regulate the expression of the human secretin receptor gene.
Topics: Adenocarcinoma; Animals; Azacitidine; Base Composition; Base Sequence; Cattle; Cells, Cultured; CpG | 2004 |
Survival efficacy of adjuvant cytosine-analogue CS-682 in a fluorescent orthotopic model of human pancreatic cancer.
Topics: Animals; Arabinonucleosides; Cell Line, Tumor; Chemotherapy, Adjuvant; Cytosine; Humans; Male; Mice; | 2004 |
Orthotopic metastatic (MetaMouse) models for discovery and development of novel chemotherapy.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Camptothecin; Cisplatin; Colonic Neoplasms; | 2005 |
The impact of hypoxic treatment on the expression of phosphoglycerate kinase and the cytotoxicity of troxacitabine and gemcitabine.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Carcinoma; Carcinoma, Hepatocellular; Cell H | 2007 |
Synergistic activity of troxacitabine (Troxatyl) and gemcitabine in pancreatic cancer.
Topics: Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; Cytosine; Deoxycytidine; Di | 2007 |
Troxacitabine prodrugs for pancreatic cancer.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cytosine; Dioxolanes; Drug Design; Drug Screening Assays, A | 2007 |
Comparison of the methylation patterns of the two rat insulin genes.
Topics: Animals; Cell Line; Cytosine; DNA; DNA Restriction Enzymes; Gene Expression Regulation; Insulin; Ins | 1983 |
The new dioxolane, (-)-2'-deoxy-3'-oxacytidine (BCH-4556, troxacitabine), has activity against pancreatic human tumor xenografts.
Topics: Animals; Antineoplastic Agents; Body Weight; Cytosine; Deoxycytidine; Dioxolanes; Dose-Response Rela | 2000 |