cytosine has been researched along with Cancer of Colon in 27 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| " Therefore, the aim of the present study was to assess a possible link between 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) background level and 5-methylcytosine content in DNA from human leukocytes of healthy subjects (n=105) as well as in patients with colon adenomas (n=39) and carcinomas (n=50)." | 7.74 | The relationship between 8-oxo-7,8-dihydro-2'-deoxyguanosine level and extent of cytosine methylation in leukocytes DNA of healthy subjects and in patients with colon adenomas and carcinomas. ( Dziaman, T; Foksinski, M; Gackowski, D; Guz, J; Olinski, R; Rozalski, R; Siomek, A; Szpila, A, 2008) |
| " We hypothesized that this polymorphism may modulate the cytotoxic effect of 5-fluorouracil (5FU) and methotrexate (MTX), two commonly used chemotherapeutic agents for colon and breast cancers, because the modes of action of 5FU and MTX are critically dependent on cellular composition of folates." | 7.72 | Effect of the methylenetetrahydrofolate reductase C677T polymorphism on chemosensitivity of colon and breast cancer cells to 5-fluorouracil and methotrexate. ( Croxford, R; Kim, YI; Lucock, M; Sohn, KJ; Yates, Z, 2004) |
| " Therefore, the aim of the present study was to assess a possible link between 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) background level and 5-methylcytosine content in DNA from human leukocytes of healthy subjects (n=105) as well as in patients with colon adenomas (n=39) and carcinomas (n=50)." | 3.74 | The relationship between 8-oxo-7,8-dihydro-2'-deoxyguanosine level and extent of cytosine methylation in leukocytes DNA of healthy subjects and in patients with colon adenomas and carcinomas. ( Dziaman, T; Foksinski, M; Gackowski, D; Guz, J; Olinski, R; Rozalski, R; Siomek, A; Szpila, A, 2008) |
| " We hypothesized that this polymorphism may modulate the cytotoxic effect of 5-fluorouracil (5FU) and methotrexate (MTX), two commonly used chemotherapeutic agents for colon and breast cancers, because the modes of action of 5FU and MTX are critically dependent on cellular composition of folates." | 3.72 | Effect of the methylenetetrahydrofolate reductase C677T polymorphism on chemosensitivity of colon and breast cancer cells to 5-fluorouracil and methotrexate. ( Croxford, R; Kim, YI; Lucock, M; Sohn, KJ; Yates, Z, 2004) |
| "More than 50% of colon cancer-associated mutations in the p53 tumor suppressor gene are C-->T transitions." | 2.41 | Thymine DNA glycosylase. ( Bentele, M; Hardeland, U; Jiricny, J; Lettieri, T; Schär, P; Steinacher, R, 2001) |
| "With these fluorescent tools, tumors and metastasis in host organs can be externally imaged down to the single-cell level." | 1.33 | Orthotopic metastatic (MetaMouse) models for discovery and development of novel chemotherapy. ( Hoffman, RM, 2005) |
| "Orthotopic colon cancer models were developed." | 1.32 | Improvement of carcinoembryonic antigen-specific prodrug gene therapy for experimental colon cancer. ( Iwahashi, M; Matsuura, I; Nakamori, M; Nakamura, M; Ojima, T; Ueda, K; Yamaue, H, 2003) |
| "Bropirimine (BP) is an immune response modifier which induces IFN." | 1.28 | Treatment of colon cancer in rats with rMuTNF and the interferon-inducer bropirimine. ( de Bruin, RW; Eggermont, AM; Jeekel, J; Marquet, RL, 1989) |
| " In the dosage used, TNF toxicity was mild, transient, and not influenced by ABPP." | 1.27 | Combined treatment of colon adenocarcinoma in rats with tumor necrosis factor and the interferon inducer ABPP. ( de Bruin, RW; Eggermont, AM; Fiers, W; Jeekel, J; Marquet, RL, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (14.81) | 18.7374 |
| 1990's | 5 (18.52) | 18.2507 |
| 2000's | 14 (51.85) | 29.6817 |
| 2010's | 4 (14.81) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Uribe-Lewis, S | 1 |
| Stark, R | 1 |
| Carroll, T | 1 |
| Dunning, MJ | 1 |
| Bachman, M | 1 |
| Ito, Y | 1 |
| Stojic, L | 1 |
| Halim, S | 1 |
| Vowler, SL | 1 |
| Lynch, AG | 1 |
| Delatte, B | 1 |
| de Bony, EJ | 1 |
| Colin, L | 1 |
| Defrance, M | 1 |
| Krueger, F | 1 |
| Silva, AL | 1 |
| Ten Hoopen, R | 1 |
| Ibrahim, AE | 1 |
| Fuks, F | 1 |
| Murrell, A | 1 |
| Chapman, CG | 1 |
| Mariani, CJ | 1 |
| Wu, F | 1 |
| Meckel, K | 1 |
| Butun, F | 1 |
| Chuang, A | 1 |
| Madzo, J | 1 |
| Bissonnette, MB | 1 |
| Kwon, JH | 1 |
| Godley, LA | 1 |
| Kowalczyk, P | 1 |
| Jaworek, J | 1 |
| Kot, M | 1 |
| Sokolowska, B | 1 |
| Bielen, A | 1 |
| Janowska, B | 1 |
| Ciesla, JM | 1 |
| Szparecki, G | 1 |
| Sados, B | 1 |
| Tudek, B | 1 |
| van den Boom, D | 2 |
| Ehrich, M | 2 |
| Haffner, MC | 1 |
| Chaux, A | 1 |
| Meeker, AK | 1 |
| Esopi, DM | 1 |
| Gerber, J | 1 |
| Pellakuru, LG | 1 |
| Toubaji, A | 1 |
| Argani, P | 1 |
| Iacobuzio-Donahue, C | 1 |
| Nelson, WG | 1 |
| Netto, GJ | 1 |
| De Marzo, AM | 1 |
| Yegnasubramanian, S | 1 |
| Toffoli, G | 1 |
| Gafà, R | 1 |
| Russo, A | 1 |
| Lanza, G | 1 |
| Dolcetti, R | 1 |
| Sartor, F | 1 |
| Libra, M | 1 |
| Viel, A | 1 |
| Boiocchi, M | 1 |
| Ueda, K | 1 |
| Iwahashi, M | 1 |
| Nakamori, M | 1 |
| Nakamura, M | 1 |
| Matsuura, I | 1 |
| Ojima, T | 1 |
| Yamaue, H | 1 |
| Wu, M | 1 |
| Mazurchuk, R | 1 |
| Chaudhary, ND | 1 |
| Spernyak, J | 1 |
| Veith, J | 1 |
| Pera, P | 1 |
| Greco, W | 1 |
| Hoffman, RM | 2 |
| Kobayashi, T | 1 |
| Bernacki, RJ | 1 |
| Sohn, KJ | 1 |
| Croxford, R | 1 |
| Yates, Z | 1 |
| Lucock, M | 1 |
| Kim, YI | 1 |
| Jiang, J | 1 |
| Gajalakshmi, V | 1 |
| Wang, J | 1 |
| Kuriki, K | 1 |
| Suzuki, S | 1 |
| Nakamura, S | 1 |
| Akasaka, S | 1 |
| Ishikawa, H | 1 |
| Tokudome, S | 1 |
| Lam, W | 1 |
| Leung, CH | 1 |
| Bussom, S | 1 |
| Cheng, YC | 2 |
| Guz, J | 1 |
| Foksinski, M | 1 |
| Siomek, A | 1 |
| Gackowski, D | 1 |
| Rozalski, R | 1 |
| Dziaman, T | 1 |
| Szpila, A | 1 |
| Olinski, R | 1 |
| Kang, MY | 1 |
| Lee, BB | 1 |
| Ji, YI | 1 |
| Jung, EH | 1 |
| Chun, HK | 1 |
| Song, SY | 1 |
| Park, SE | 1 |
| Park, J | 1 |
| Kim, DH | 1 |
| Turner, J | 1 |
| Gibbs, P | 1 |
| Lipton, L | 1 |
| Giovanneti, M | 1 |
| Cantor, C | 1 |
| Grove, KL | 1 |
| Guo, X | 1 |
| Liu, SH | 1 |
| Gao, Z | 1 |
| Chu, CK | 1 |
| Schmutte, C | 1 |
| Yang, AS | 1 |
| Nguyen, TT | 1 |
| Beart, RW | 1 |
| Jones, PA | 1 |
| Pfeifer, GP | 1 |
| Denissenko, MF | 1 |
| Côté, S | 1 |
| Sinnett, D | 1 |
| Momparler, RL | 1 |
| Dong, Z | 1 |
| Wang, X | 1 |
| Evers, BM | 1 |
| Tsukuda, K | 1 |
| Tanino, M | 1 |
| Soga, H | 1 |
| Shimizu, N | 1 |
| Shimizu, K | 1 |
| Hardeland, U | 1 |
| Bentele, M | 1 |
| Lettieri, T | 1 |
| Steinacher, R | 1 |
| Jiricny, J | 1 |
| Schär, P | 1 |
| Roh, MS | 1 |
| Kahky, MP | 1 |
| Oyedeji, C | 1 |
| Klostergaard, J | 1 |
| Wang, L | 1 |
| Curley, SA | 1 |
| Lotzová, E | 1 |
| Marquet, RL | 3 |
| de Bruin, RW | 3 |
| Eggermont, AM | 3 |
| Jeekel, J | 3 |
| Feinberg, AP | 1 |
| Gehrke, CW | 1 |
| Kuo, KC | 1 |
| Ehrlich, M | 1 |
| Fiers, W | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Indentifying Epigenetic Biomarkers From Peripheral Blood of Osteosarcoma Patients Based on hMe-Seal Technique[NCT03336554] | 100 participants (Anticipated) | Observational [Patient Registry] | 2017-09-01 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for cytosine and Cancer of Colon
| Article | Year |
|---|---|
Formation and repair of DNA lesions in the p53 gene: relation to cancer mutations?
Topics: 5-Methylcytosine; Animals; Benzo(a)pyrene; Breast Neoplasms; Carcinogens, Environmental; Colonic Neo | 1998 |
Thymine DNA glycosylase.
Topics: Amino Acid Sequence; Animals; Bacterial Proteins; Base Pair Mismatch; Base Sequence; Cell Transforma | 2001 |
25 other studies available for cytosine and Cancer of Colon
| Article | Year |
|---|---|
5-hydroxymethylcytosine marks promoters in colon that resist DNA hypermethylation in cancer.
Topics: 5-Methylcytosine; Cell Proliferation; Colonic Neoplasms; Cytosine; Dioxygenases; DNA Methylation; DN | 2015 |
TET-catalyzed 5-hydroxymethylcytosine regulates gene expression in differentiating colonocytes and colon cancer.
Topics: 5-Methylcytosine; Adenocarcinoma; Binding Sites; Cell Differentiation; Cell Line, Tumor; Colon; Colo | 2015 |
Inflammation increases oxidative DNA damage repair and stimulates preneoplastic changes in colons of newborn rats.
Topics: Adenine; Animals; Animals, Newborn; Arachidonate 12-Lipoxygenase; Colon; Colonic Neoplasms; Cyclooxy | 2016 |
Mass spectrometric analysis of cytosine methylation by base-specific cleavage and primer extension methods.
Topics: Animals; Colonic Neoplasms; CpG Islands; Cytosine; DNA; DNA Methylation; DNA Primers; DNA, Neoplasm; | 2009 |
Global 5-hydroxymethylcytosine content is significantly reduced in tissue stem/progenitor cell compartments and in human cancers.
Topics: 5-Methylcytosine; Adenocarcinoma; Animals; Breast Neoplasms; Carcinoma, Ductal, Breast; Cell Differe | 2011 |
Methylenetetrahydrofolate reductase 677 C-->T polymorphism and risk of proximal colon cancer in north Italy.
Topics: Alleles; Colonic Neoplasms; Cytosine; DNA Methylation; Gene Silencing; Genotype; Humans; Italy; Meth | 2003 |
Improvement of carcinoembryonic antigen-specific prodrug gene therapy for experimental colon cancer.
Topics: Adenoviridae; Antimetabolites, Antineoplastic; Carcinoembryonic Antigen; Colonic Neoplasms; Cytosine | 2003 |
High-resolution magnetic resonance imaging of the efficacy of the cytosine analogue 1-[2-C-cyano-2-deoxy-beta-D-arabino-pentofuranosyl]-N(4)-palmitoyl cytosine (CS-682) in a liver-metastasis athymic nude mouse model.
Topics: Animals; Antineoplastic Agents; Arabinonucleosides; Cell Division; Colonic Neoplasms; Cytosine; Deox | 2003 |
Effect of the methylenetetrahydrofolate reductase C677T polymorphism on chemosensitivity of colon and breast cancer cells to 5-fluorouracil and methotrexate.
Topics: Alanine; Animals; Antimetabolites, Antineoplastic; Blotting, Western; Breast Neoplasms; Cell Line, T | 2004 |
Orthotopic metastatic (MetaMouse) models for discovery and development of novel chemotherapy.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Camptothecin; Cisplatin; Colonic Neoplasms; | 2005 |
Influence of the C161T but not Pro12Ala polymorphism in the peroxisome proliferator-activated receptor-gamma on colorectal cancer in an Indian population.
Topics: Adult; Aged; Alanine; Colonic Neoplasms; Colorectal Neoplasms; Cytosine; Gene Frequency; Haplotypes; | 2005 |
The impact of hypoxic treatment on the expression of phosphoglycerate kinase and the cytotoxicity of troxacitabine and gemcitabine.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Carcinoma; Carcinoma, Hepatocellular; Cell H | 2007 |
The relationship between 8-oxo-7,8-dihydro-2'-deoxyguanosine level and extent of cytosine methylation in leukocytes DNA of healthy subjects and in patients with colon adenomas and carcinomas.
Topics: 5-Methylcytosine; 8-Hydroxy-2'-Deoxyguanosine; Adenoma; Adult; Aged; Aged, 80 and over; Carcinoma; C | 2008 |
Association of interindividual differences in p14ARF promoter methylation with single nucleotide polymorphism in primary colorectal cancer.
Topics: Adenine; Colonic Neoplasms; CpG Islands; Cytosine; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytos | 2008 |
Cytosine methylation profiling of cancer cell lines.
Topics: Cell Line, Tumor; Cluster Analysis; Colonic Neoplasms; Cytosine; DNA Methylation; Gene Expression Pr | 2008 |
Anticancer activity of beta-L-dioxolane-cytidine, a novel nucleoside analogue with the unnatural L configuration.
Topics: Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Division; Colonic Neoplasms; Cytarab | 1995 |
Mechanisms for the involvement of DNA methylation in colon carcinogenesis.
Topics: Base Sequence; Cell Transformation, Neoplastic; Colonic Neoplasms; Cytosine; DNA; DNA (Cytosine-5-)- | 1996 |
Demethylation by 5-aza-2'-deoxycytidine of specific 5-methylcytosine sites in the promoter region of the retinoic acid receptor beta gene in human colon carcinoma cells.
Topics: 5-Methylcytosine; Adenocarcinoma; Antimetabolites, Antineoplastic; Azacitidine; Base Sequence; Colon | 1998 |
Site-specific DNA methylation contributes to neurotensin/neuromedin N expression in colon cancers.
Topics: Adult; Base Sequence; Colonic Neoplasms; Consensus Sequence; Cytosine; DNA Methylation; Electrophore | 2000 |
A novel activating mutation of the K-ras gene in human primary colon adenocarcinoma.
Topics: 3T3 Cells; Adenine; Adenocarcinoma; Animals; Base Sequence; Cell Transformation, Neoplastic; Colonic | 2000 |
Murine Kupffer cells and hepatic natural killer cells regulate tumor growth in a quantitative model of colorectal liver metastases.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Cell Division; Cell Line; Cell Survival; Colonic Neo | 1992 |
Treatment of colon cancer in rats with rMuTNF and the interferon-inducer bropirimine.
Topics: Animals; Colonic Neoplasms; Cytosine; Interferon Inducers; Male; Mice; Rats; Rats, Inbred Strains; R | 1989 |
Effects of the interferon-inducer ABPP on colon cancer in rats; importance of tumor load and tumor site.
Topics: Animals; Antineoplastic Agents; Colonic Neoplasms; Cytosine; Dose-Response Relationship, Drug; Inter | 1986 |
Reduced genomic 5-methylcytosine content in human colonic neoplasia.
Topics: 5-Methylcytosine; Adult; Aged; Colonic Neoplasms; Cytosine; DNA, Neoplasm; Gardner Syndrome; Humans; | 1988 |
Combined treatment of colon adenocarcinoma in rats with tumor necrosis factor and the interferon inducer ABPP.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Colonic Neoplasms; Cytosine; Drug Therapy, Combinati | 1988 |