cytosine has been researched along with Brain Neoplasms in 20 studies
Brain Neoplasms: Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Here, we show that TET1-mediated production of 5-hydroxymethylcytosine (5hmC) is required for the tumorigenicity of glioblastoma cells." | 7.80 | 5-Hydroxymethylcytosine plays a critical role in glioblastomagenesis by recruiting the CHTOP-methylosome complex. ( Akiyama, T; Ino, Y; Katou, Y; Koyama-Nasu, R; Kozuka-Hata, H; Masuda, K; Morishita, Y; Mukasa, A; Nasu-Nishimura, Y; Ogawa, H; Oyama, M; Saito, N; Sakaguchi, Y; Sato, T; Shirahige, K; Suzuki, T; Takai, H; Todo, T; Toyoshima, C, 2014) |
| "Gliomas are incurable brain cancers with poor prognosis, with epigenetic dysregulation being a distinctive feature." | 5.72 | Ascorbate content of clinical glioma tissues is related to tumour grade and to global levels of 5-hydroxymethyl cytosine. ( Burgess, ER; Crake, RLI; Dachs, GU; Das, AB; Magon, NJ; Morrin, HR; Phillips, E; Robinson, BA; Royds, JA; Slatter, TL; Vissers, MCM; Wiggins, GAR, 2022) |
| " Here, we show that TET1-mediated production of 5-hydroxymethylcytosine (5hmC) is required for the tumorigenicity of glioblastoma cells." | 3.80 | 5-Hydroxymethylcytosine plays a critical role in glioblastomagenesis by recruiting the CHTOP-methylosome complex. ( Akiyama, T; Ino, Y; Katou, Y; Koyama-Nasu, R; Kozuka-Hata, H; Masuda, K; Morishita, Y; Mukasa, A; Nasu-Nishimura, Y; Ogawa, H; Oyama, M; Saito, N; Sakaguchi, Y; Sato, T; Shirahige, K; Suzuki, T; Takai, H; Todo, T; Toyoshima, C, 2014) |
| "Gliomas are incurable brain cancers with poor prognosis, with epigenetic dysregulation being a distinctive feature." | 1.72 | Ascorbate content of clinical glioma tissues is related to tumour grade and to global levels of 5-hydroxymethyl cytosine. ( Burgess, ER; Crake, RLI; Dachs, GU; Das, AB; Magon, NJ; Morrin, HR; Phillips, E; Robinson, BA; Royds, JA; Slatter, TL; Vissers, MCM; Wiggins, GAR, 2022) |
| "In squamous cell lung cancers, levels of 5hmdC were depleted substantially with up to 5-fold reduction compared with normal lung tissue." | 1.37 | 5-Hydroxymethylcytosine is strongly depleted in human cancers but its levels do not correlate with IDH1 mutations. ( Jiang, Y; Jin, SG; Krex, D; Lu, Q; Pfeifer, GP; Qiu, R; Rauch, TA; Schackert, G; Wang, Y, 2011) |
| " In vitro studies showed that 5-FC combined with CDase induced significant growth-inhibitory effects on the cultured glioma cells." | 1.27 | Antineoplastic effects in rats of 5-fluorocytosine in combination with cytosine deaminase capsules. ( Ito, T; Katsuragi, T; Kawamoto, K; Kawamura, Y; Matsumura, H; Nishiyama, T; Ohyama, A; Sakai, T; Yamamoto, N, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (15.00) | 18.7374 |
| 1990's | 2 (10.00) | 18.2507 |
| 2000's | 5 (25.00) | 29.6817 |
| 2010's | 8 (40.00) | 24.3611 |
| 2020's | 2 (10.00) | 2.80 |
| Authors | Studies |
|---|---|
| Crake, RLI | 1 |
| Burgess, ER | 1 |
| Wiggins, GAR | 1 |
| Magon, NJ | 1 |
| Das, AB | 1 |
| Vissers, MCM | 1 |
| Morrin, HR | 1 |
| Royds, JA | 1 |
| Slatter, TL | 1 |
| Robinson, BA | 1 |
| Phillips, E | 1 |
| Dachs, GU | 1 |
| Galardi, S | 1 |
| Michienzi, A | 1 |
| Ciafrè, SA | 1 |
| Kazlauskas, A | 1 |
| Darinskas, A | 1 |
| Meškys, R | 1 |
| Tamašauskas, A | 1 |
| Urbonavičius, J | 1 |
| Hadaczek, P | 1 |
| Ozawa, T | 1 |
| Soroceanu, L | 1 |
| Yoshida, Y | 1 |
| Matlaf, L | 1 |
| Singer, E | 1 |
| Fiallos, E | 1 |
| James, CD | 1 |
| Cobbs, CS | 1 |
| Ye, C | 1 |
| Li, L | 1 |
| Takai, H | 1 |
| Masuda, K | 1 |
| Sato, T | 1 |
| Sakaguchi, Y | 1 |
| Suzuki, T | 2 |
| Koyama-Nasu, R | 1 |
| Nasu-Nishimura, Y | 1 |
| Katou, Y | 1 |
| Ogawa, H | 1 |
| Morishita, Y | 1 |
| Kozuka-Hata, H | 1 |
| Oyama, M | 1 |
| Todo, T | 1 |
| Ino, Y | 1 |
| Mukasa, A | 1 |
| Saito, N | 1 |
| Toyoshima, C | 1 |
| Shirahige, K | 1 |
| Akiyama, T | 1 |
| Ramsawhook, A | 1 |
| Lewis, L | 1 |
| Coyle, B | 1 |
| Ruzov, A | 1 |
| Tasca, G | 1 |
| Iorio, R | 1 |
| Basile, U | 1 |
| Lauriola, L | 1 |
| Tartaglione, R | 1 |
| Mirabella, M | 1 |
| Ricci, E | 1 |
| Sabatelli, M | 1 |
| Jin, SG | 1 |
| Jiang, Y | 1 |
| Qiu, R | 1 |
| Rauch, TA | 1 |
| Wang, Y | 1 |
| Schackert, G | 1 |
| Krex, D | 1 |
| Lu, Q | 1 |
| Pfeifer, GP | 1 |
| Kraus, TF | 1 |
| Globisch, D | 1 |
| Wagner, M | 1 |
| Eigenbrod, S | 1 |
| Widmann, D | 1 |
| Münzel, M | 1 |
| Müller, M | 1 |
| Pfaffeneder, T | 1 |
| Hackner, B | 1 |
| Feiden, W | 1 |
| Schüller, U | 1 |
| Carell, T | 1 |
| Kretzschmar, HA | 1 |
| Müller, T | 1 |
| Gessi, M | 1 |
| Waha, A | 2 |
| Isselstein, LJ | 1 |
| Luxen, D | 1 |
| Freihoff, D | 1 |
| Freihoff, J | 1 |
| Becker, A | 1 |
| Simon, M | 1 |
| Hammes, J | 1 |
| Denkhaus, D | 1 |
| zur Mühlen, A | 1 |
| Pietsch, T | 1 |
| Kaliberov, SA | 1 |
| Market, JM | 1 |
| Gillespie, GY | 1 |
| Krendelchtchikova, V | 1 |
| Della Manna, D | 1 |
| Sellers, JC | 1 |
| Kaliberova, LN | 1 |
| Black, ME | 1 |
| Buchsbaum, DJ | 1 |
| Nishiyama, T | 2 |
| Kawamura, Y | 2 |
| Kawamoto, K | 2 |
| Matsumura, H | 2 |
| Yamamoto, N | 2 |
| Ito, T | 2 |
| Ohyama, A | 2 |
| Katsuragi, T | 2 |
| Sakai, T | 2 |
| Woodcock, DM | 1 |
| Adams, JK | 1 |
| Allan, RG | 1 |
| Cooper, IA | 1 |
| Merlo, A | 1 |
| Herman, JG | 1 |
| Mao, L | 1 |
| Lee, DJ | 1 |
| Gabrielson, E | 1 |
| Burger, PC | 1 |
| Baylin, SB | 1 |
| Sidransky, D | 1 |
| Liekens, S | 3 |
| Andrei, G | 1 |
| Vandeputte, M | 1 |
| De Clercq, E | 3 |
| Neyts, J | 3 |
| al-Ghamdi, H | 1 |
| Sabbah, R | 1 |
| Martin, J | 1 |
| Patay, Z | 1 |
| Verbeken, E | 2 |
| Ribatti, D | 1 |
| Presta, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Efficacy and Safety Assessment of Oral LBH589 in Adult Patients With Advanced Soft Tissue Sarcoma After Pre-treatment Failure: an Open-label, Multicenter Phase II Study[NCT01136499] | Phase 2 | 53 participants (Actual) | Interventional | 2010-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for cytosine and Brain Neoplasms
| Article | Year |
|---|---|
Insights into the Regulatory Role of m
Topics: Adenosine; Brain Neoplasms; Cytosine; Epigenesis, Genetic; Gene Expression Profiling; Gene Expressio | 2020 |
5-hydroxymethylcytosine: a new insight into epigenetics in cancer.
Topics: 5-Methylcytosine; Animals; Brain Neoplasms; Cytosine; Dioxygenases; DNA Methylation; DNA-Binding Pro | 2014 |
18 other studies available for cytosine and Brain Neoplasms
| Article | Year |
|---|---|
Ascorbate content of clinical glioma tissues is related to tumour grade and to global levels of 5-hydroxymethyl cytosine.
Topics: Brain Neoplasms; Cytosine; DNA Methylation; Glioma; Humans; Neoplasm Grading; O(6)-Methylguanine-DNA | 2022 |
Isocytosine deaminase Vcz as a novel tool for the prodrug cancer therapy.
Topics: Adenocarcinoma; Animals; Antimetabolites, Antineoplastic; Brain Neoplasms; Caco-2 Cells; Cell Line, | 2019 |
Cidofovir: a novel antitumor agent for glioblastoma.
Topics: Animals; Antineoplastic Agents; Apoptosis; Brain Neoplasms; Cell Line, Tumor; Cell Survival; Cidofov | 2013 |
5-Hydroxymethylcytosine plays a critical role in glioblastomagenesis by recruiting the CHTOP-methylosome complex.
Topics: 5-Methylcytosine; Acetylation; Brain Neoplasms; Carcinogenesis; Chromatin; Cytosine; DNA-Binding Pro | 2014 |
Medulloblastoma and ependymoma cells display increased levels of 5-carboxylcytosine and elevated
Topics: 5-Methylcytosine; Brain Neoplasms; Cell Line, Tumor; Cerebellar Neoplasms; Child; Cytosine; Ependymo | 2017 |
Progressive multifocal leukoencephalopathy in a patient with Franklin disease and hypogammaglobulinemia.
Topics: Adenocarcinoma; Agammaglobulinemia; Aged; Antiviral Agents; Brain; Brain Neoplasms; Cidofovir; Cytos | 2009 |
5-Hydroxymethylcytosine is strongly depleted in human cancers but its levels do not correlate with IDH1 mutations.
Topics: 5-Methylcytosine; Animals; Base Sequence; Brain; Brain Neoplasms; Carcinoma, Squamous Cell; Cell Lin | 2011 |
Low values of 5-hydroxymethylcytosine (5hmC), the "sixth base," are associated with anaplasia in human brain tumors.
Topics: 5-Methylcytosine; Adolescent; Adult; Aged; Aged, 80 and over; Anaplasia; Astrocytoma; Brain; Brain N | 2012 |
Nuclear exclusion of TET1 is associated with loss of 5-hydroxymethylcytosine in IDH1 wild-type gliomas.
Topics: 5-Methylcytosine; Brain Neoplasms; Cell Line, Tumor; Cell Nucleus; Cytosine; Dioxygenases; DNA Methy | 2012 |
Mutation of Escherichia coli cytosine deaminase significantly enhances molecular chemotherapy of human glioma.
Topics: Adenoviridae; Animals; Antimetabolites; Brain Neoplasms; Cell Line, Tumor; Combined Modality Therapy | 2007 |
[Antineoplastic effect of 5-fluorocytosine and cytosine deaminase on brain tumor (author's transl)].
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Cytosine; Cytosine Deaminase; Drug Therapy, Combina | 1982 |
Effect of several inhibitors of enzymatic DNA methylation on the in vivo methylation of different classes of DNA sequences in a cultured human cell line.
Topics: 5-Methylcytosine; Adenosine; Azacitidine; Brain Neoplasms; Cell Division; Cell Line; Cycloleucine; C | 1983 |
5' CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers.
Topics: 5-Methylcytosine; Alleles; Azacitidine; Base Sequence; Brain Neoplasms; Carcinoma, Non-Small-Cell Lu | 1995 |
Potent inhibition of hemangioma formation in rats by the acyclic nucleoside phosphonate analogue cidofovir.
Topics: Animals; Antiviral Agents; Body Weight; Brain Neoplasms; Cidofovir; Cytosine; Hemangioma; Incidence; | 1998 |
Primary T-cell lymphoma of the brain in children: a case report and literature review.
Topics: Antineoplastic Combined Chemotherapy Protocols; Arabinose; Asparaginase; Brain Neoplasms; Child; Com | 2000 |
Potent inhibition of hemangiosarcoma development in mice by cidofovir.
Topics: Animals; Antineoplastic Agents; Apoptosis; Brain Neoplasms; Cell Division; Cell Line, Transformed; C | 2001 |
Inhibition of fibroblast growth factor-2-induced vascular tumor formation by the acyclic nucleoside phosphonate cidofovir.
Topics: Animals; Antineoplastic Agents; Antiviral Agents; Apoptosis; Brain Neoplasms; Cell Division; Chick E | 2001 |
Antineoplastic effects in rats of 5-fluorocytosine in combination with cytosine deaminase capsules.
Topics: Animals; Brain Neoplasms; Capsules; Cytosine; Cytosine Deaminase; Drug Evaluation, Preclinical; Drug | 1985 |